73 results on '"Hantong Hu"'
Search Results
2. Efficacy and safety of transcutaneous auricular vagus nerve stimulation (ta-VNS) in the treatment of tinnitus: protocol for an updated systematic review and meta-analysis
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Xiaoqi Lin, Hantong Hu, Yiyan Fang, and Ziyu Ye
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Medicine - Abstract
Introduction With an increasing incidence and significant effects on patients, tinnitus has become a major disease burden. There is a dearth of therapies with established efficacy for tinnitus. Transcutaneous auricular vagus nerve stimulation (ta-VNS) is being investigated as a potential therapy for tinnitus, but the current body of evidence remains inconclusive due to conflicting results across different studies. As a result, this protocol aims to synthesise and update the evidence to clarify whether ta-VNS is effective and safe for alleviating tinnitus.Methods and analysis To identify relevant randomised controlled trials (RCTs), seven representative bibliographical databases will be searched from their inception to December 2023: PubMed, Embase (via OVID), Cochrane Library, Chinese National Knowledge Infrastructure, Wangfang Database, Chinese BioMedical Literature Database, and Chongqing VIP Chinese Science and Technology Periodical Database. Publications in English or Chinese will be considered for inclusion. RCTs comparing ta-VNS with active treatments, no intervention, waitlist control or sham ta-VNS in adult patients with subjective tinnitus will be included. Studies on objective tinnitus will be excluded. Primary outcome is tinnitus symptom severity measured by validated scales. With all eligible trials included, when applicable, quantitative analysis via meta-analyses will be performed using RevMan V.5.4.1 software. Otherwise, a qualitative analysis will be conducted. The methodological quality of the included RCTs will be assessed using the Risk of Bias 2.0 tool. Sensitivity analyses, subgroup analysis and publication bias evaluation will also be performed. The Grading of Recommendations, Assessment, Development, and Evaluation approach will be used to grade the certainty of the evidence.Ethics and dissemination Ethical approval is not required for this systematic review, as no primary data will be collected. The results will be reported and disseminated through publication in a peer-reviewed journal.PROSPERO registration number CRD42022351917.
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- 2024
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3. Evaluating the efficacy and acceptability of vagus nerve stimulation for fibromyalgia: a PRISMA-compliant protocol for a systematic review and meta-analysis
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Yunhuo Cai, Yajun Zhang, Yiyan Fang, Hantong Hu, Xingling Li, and Lianqiang Fang
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fibromyalgia ,vagus nerve stimulation ,protocol ,efficacy ,acceptability ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundFibromyalgia has imposed substantial burdens on patients’ health and well-being, yet effective therapeutic options for this condition remain limited. Recently, vagus nerve stimulation (VNS) has emerged as a promising therapy for fibromyalgia. Nonetheless, despite the increasing number of randomized clinical trials (RCTs), current evidence remains inconclusive. Therefore, this protocol of a systematic review and meta-analysis aims to synthesize the existing evidence to clarify the efficacy and acceptability of VNS for treating fibromyalgia.MethodsA comprehensive search for eligible RCTs will be conducted across nine bibliographic databases, namely PubMed, Cochrane Library, Embase, AMED, PsycINFO, PEDro, Chinese BioMedical Literature Database, Chinese National Knowledge Infrastructure, and Wangfang database. Data obtained from the included studies will be synthesized quantitively using RevMan 5.4.1 for meta-analyses. The methodological soundness of included RCTs will be assessed via the Cochrane’s updated risk of bias tool (version 2.0). Additionally, sensitivity analyses, publication bias assessment, and subgroup analyses will be conducted as appropriate. Finally, we will utilize the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to evaluate the certainty for the body of evidence.ConclusionThe findings of our study are anticipated to ascertain the efficacy and acceptability of VNS as a promising treatment option for fibromyalgia. This will not only fill current research gap but also identify potential areas for future research. The findings will provide essential guidance for evidence-based treatment decisions for fibromyalgia, benefiting both patients and clinicians.
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- 2024
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4. Application of functional near-infrared spectroscopy (fNIRS) in tinnitus research: contemporary insights and perspectives
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Hantong Hu, Xiaoqi Lin, Ziyu Ye, Lianqiang Fang, Hong Gao, and Quanai Zhang
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tinnitus ,phantom sound ,fNIRS ,neuroimaging ,brain plasticity ,Psychology ,BF1-990 - Abstract
Tinnitus, characterized by phantom sound perception, is a highly disruptive condition lacking clearly effective treatments. Its complex neural mechanisms are not fully elucidated. Functional near-infrared spectroscopy (fNIRS) is a promising neuroimaging tool well-suited for assessing tinnitus due to its quietness, portability, and ability to directly measure cortical hemodynamic responses. This study timely summarizes the recent applications of fNIRS in investigating tinnitus pathology, correlating neuroimaging biomarkers with symptom severity, and evaluating treatment efficacy. Further studies with larger samples are warranted to reproduce existing findings. Thus, fNIRS appears to be a promising tool in tinnitus research. Addressing technical limitations, optimizing control groups, advancing data analysis, integrating standardized, and individualized experimental protocols can facilitate the extended and robust utilization of fNIRS in tinnitus research.
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- 2024
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5. Letter regarding 'Effect of the acupuncture within 24 hour after the onset of peripheral facial paralysis'
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Tianye Hu and Hantong Hu
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Surgery ,RD1-811 - Published
- 2023
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6. Auricular acupuncture for persistent insomnia and anxiety associated with COVID-19: a case report
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Hantong Hu, YingYing Cheng, Lianqiang Fang, Liping Yang, and Xingling Li
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COVID-19 ,auricular acupuncture ,insomnia ,sleep disorders ,anxiety ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
The coronavirus disease 2019 (COVID-19) has been associated with various psychological symptoms. We report a case of a female patient who was diagnosed with persistent insomnia and anxiety associated with COVID-19, which was successfully treated with nine treatment sessions of auricular acupuncture. This case report provides preliminary evidence to support further research into auricular acupuncture as a potential therapy for persistent insomnia and anxiety associated with COVID-19.
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- 2023
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7. The effective on intradermal acupuncture based on changes in biological specificity of acupoints for major depressive disorder: study protocol of a prospective, multicenter, randomized, controlled trial
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Mingqi Tu, Xiaoting Wu, Siying Qu, Junyan Jin, Nisang Chen, Sangsang Xiong, Shuangyi Pei, Xinwei Li, Yan Shi, Hantong Hu, Xiaoyu Li, Jianqiao Fang, and Xiaomei Shao
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major depressive disorder ,intradermal acupuncture ,biological specificity ,acupoint ,study protocol ,prospective study ,Psychiatry ,RC435-571 - Abstract
BackgroundAntidepressants still have some side effects in treating major depressive disorder (MDD), and acupuncture therapy is a complementary therapy of research interest for MDD. Acupoints are sensitive sites for disease response and stimulation points for acupuncture treatment. Prior studies suggest that the biological specificity of acupoints is altered in physiological and pathological situations. Therefore, we hypothesize that the biological specificity of acupoints is associated with the diagnosis of MDD and that stimulating acupoints with significant biological specificity can achieve a better therapeutic effect than clinical common acupoints. This study aims to investigate the efficacy and safety of intradermal acupuncture (IA) treatment for MDD based on changes in the biological specificity of acupoints.MethodsThe first part of the study will enroll 30 MDD patients and 30 healthy control (HC) participants to assess pain sensitivity and thermal specificity of MDD-related acupoints using a pressure pain threshold gauge (PTG) and infrared thermography (IRT). The potentially superior acupoints for treating MDD will be selected based on the results of PTG and IRT tests and referred to as pressure pain threshold strong response acupoints (PSA) and temperature strong response acupoints (TSA).The second part of the study will enroll 120 eligible MDD patients randomly assigned to waiting list (WL) group, clinical common acupoint (CCA) group, TSA group, and PSA group in a 1:1:1:1 ratio. The change in the Patient Health Questionnaire-9 Items (PHQ-9), the MOS item short-form health survey (SF-36), pressure pain threshold, temperature of acupoints, and adverse effects will be observed. The outcomes of PHQ-9 and SF-36 measures will be assessed before intervention, at 3 and 6 weeks after intervention, and at a 4-week follow-up. The biological specificity of acupoint measures will be assessed before intervention and at 6 weeks after intervention. All adverse effects will be assessed.DiscussionThis study will evaluate the therapeutic effect and safety of IA for MDD based on changes in the biological specificity of acupoints. It will investigate whether there is a correlation between the biological specificity of MDD-related acupoints and the diagnosis of MDD and whether stimulating strong response acupoints is superior to clinical common acupoints in the treatment of MDD. The study’s results may provide insights into the biological mechanisms of acupuncture and its potential as a complementary therapy for MDD.Clinical Trial RegistrationClinicalTrials.gov, identifier: NCT05524519.
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- 2023
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8. The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a study protocol for a randomized controlled trial
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Xiaoting Wu, Mingqi Tu, Nisang Chen, Jiajia Yang, Junyan Jin, Siying Qu, Sangsang Xiong, Zhijian Cao, Maosheng Xu, Shuangyi Pei, Hantong Hu, Yinyan Ge, Jianqiao Fang, and Xiaomei Shao
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major depressive disorder ,intradermal acupuncture ,cerebral mechanism ,magnetic resonance imaging ,magnetic resonance spectroscopy ,selective serotonin reuptake inhibitors ,Psychiatry ,RC435-571 - Abstract
BackgroundMajor depressive disorder (MDD) has emerged as the fifth leading cause of years lived with disability, with a high prevalent, affecting nearly 4% of the global population. While available evidence suggests that intradermal acupuncture may enhance the effectiveness of antidepressants, whether its efficacy is a specific therapeutic effect or a placebo effect has not been reported. Moreover, the cerebral mechanism of intradermal acupuncture as a superficial acupuncture (usually subcutaneous needling to a depth of 1–2 mm) for MDD remains unclear.MethodsA total of 120 participants with MDD will be enrolled and randomized to the waiting list group, sham intradermal acupuncture group and active intradermal acupuncture group. All 3 groups will receive a 6-week intervention and a 4-week follow-up. The primary outcome will be measured by the Hamilton Depression Rating Scale-17 and the secondary outcome measures will be the Self-Rating depression scale and Pittsburgh sleep quality index. Assessments will be conducted at baseline, 3 weeks, 6 weeks, and during the follow-up period. In addition, 20 eligible participants in each group will be randomly selected to undergo head magnetic resonance imaging before and after the intervention to explore the effects of intradermal acupuncture on brain activity in MDD patients.DiscussionIf the intradermal acupuncture is beneficial, it is promising to be included in the routine treatment of MDD.Clinical Trial RegistrationClinicaltrials.gov, NCT05720637.
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- 2023
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9. Specificity for the correlation between the body surface and viscera in the pathological state of COPD: A prospective, controlled, and assessor-blinded trial
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Yongliang Jiang, Hantong Hu, Xiaofen He, Xiaoyu Li, Yajun Zhang, Jiali Lou, Yuanyuan Wu, Junfan Fang, Xiaomei Shao, and Jianqiao Fang
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site specificity ,infrared thermography ,comparative study ,acupuncture ,skin physiology ,Physiology ,QP1-981 - Abstract
Background: The association between the body surface and viscera remains obscure, but a better understanding of the body surface-viscera correlation will maximize its diagnostic and therapeutic values in clinical practice. Therefore, this study aimed to investigate the specificity of body surface-viscera correlation in the pathological state.Methods: The study subjects included 40 participants with chronic obstructive pulmonary disease (COPD) in the COPD group and 40 age-matched healthy participants in the healthy control group. Laser Doppler flowmetry, infrared thermography, and functional near-infrared spectroscopy were respectively adopted to measure 1) the perfusion unit (PU), 2) temperature, and 3) regional oxygen saturation (rSO2) of four specific sites distributed in the heart and lung meridians. These three outcome measures reflected the microcirculatory, thermal, and metabolic characteristics, respectively.Results: Regarding the microcirculatory and thermal characteristics of the body surface, the PU and temperature of specific sites on the body surface [i.e., Taiyuan (LU9) and Chize (LU5) in the lung meridian] in the COPD group were significantly increased compared with healthy controls (p < 0.05), whereas PU and temperature of other sites in the heart meridian [i.e., Shenmen (HT7) and Shaohai (HT3)] did not change significantly (p > 0.05). Regarding the metabolic characteristics, rSO2 of specific sites in the lung meridian [i.e., Taiyuan (LU9) and Chize (LU5)] and Shaohai (HT3) of the heart meridian in the COPD group was significantly decreased compared with healthy controls (p < 0.01), whereas rSO2 of Shenmen (HT7) in the heart meridian did not change significantly (p > 0.05).Conclusion: In the disease state of COPD, the microcirculatory, thermal, and metabolic characteristics of specific sites on the body surface in the lung meridian generally manifest more significant changes than those in the heart meridian, thereby supporting relative specificity for the body surface-viscera correlation in the pathological state.
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- 2023
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10. Bibliometric analysis of publication trends and research hotspots in vagus nerve stimulation: A 20-year panorama
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Rongrong Li, Hantong Hu, Ning Luo, and Jianqiao Fang
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vagus nerve stimulation ,neuromodulation ,neurophysiology ,bibliometrics ,visualization ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundAs a promising neuromodulation technique, vagus nerve stimulation (VNS) has been utilized to treat diverse diseases and the number of VNS studies has grown prosperously. Nonetheless, publication trends and research hotspots in this field remain unknown. This study aimed to perform a bibliometric analysis to systematically identify publication trends and research hotspots in VNS research within a 20-year panorama.MethodsThe Web of Science Core Collection (WoSCC) database was retrieved to screen eligible VNS-related publications from 2002 to 2021. The online analytic tool of the WoSCC database was used to analyze various bibliometric parameters, such as the number of annual publications, the output of countries/regions, journals, total citations, citations per publication, and the Hirsch index. Bibliometrics (http://bibliometric.com/) and CiteSpace (version 5.6.R3) were used to identify research trends and hotspots.ResultsA total of 7,283 publications were included for analysis. The annual number of publications increased stably but it increased significantly in recent years. The top five prolific countries were the United States, China, Germany, England, and France. The top five productive institutions were the University of California (Los Angeles), Harvard Medical School, Harvard University, University College London, and the University of Texas at Dallas. Notably, there was a geographical imbalance in countries and institutions. In addition, Epilepsy & Behavior, Epilepsia, and Plos One were the top three journals with the largest number of VNS publications. Michael P Kilgard was the most prolific author. Moreover, evolving research hotspots mainly included the effectiveness and mechanism of VNS on epilepsy, the role of VNS as an anti-inflammatory regulator, the application of VNS for psychiatric disorders, and the neuromodulation effect of VNS in headache management.ConclusionThis study has revealed the overall publication trends and evolving research trends at a global level over a 20-year panorama. The potential collaborators, institutions, hotspots, and future research trends are also identified in this field, which will help guide new research directions of VNS.
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- 2022
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11. Integrative medicine in treating post-stroke depression: Study protocol for a multicenter, prospective, randomized, controlled trial
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Jing Chen, Ke Shen, Lijuan Fan, Hantong Hu, Tieniu Li, Yiting Zhang, and Hong Gao
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post-stroke depression ,integrative medicine ,acupuncture ,traditional Chinese medicine ,repeated transcranial magnetic stimulation ,Psychology ,BF1-990 - Abstract
BackgroundPost-stroke depression (PSD) is one of the most common neuropsychiatric diseases in patients with stroke, and it can increase the disability rate, mortality, and recurrence rate of stroke. Currently, many clinical studies have indicated that traditional Chinese medicine (TCM), such as acupuncture and herbs, Western medicine, rehabilitation, repeated transcranial magnetic stimulation, and other treatment methods, are effective in treating PSD. However, no study has formulated a comprehensive treatment plan that integrates TCM, Western medicine, and rehabilitation for PSD. Thus, this trial aims to assess the efficacy and safety of integrative medicine for treating PSD.MethodsThis multicenter, prospective, randomized, controlled study aims to form a set of effective clinical treatment schemes that integrate TCM, Western medicine, and rehabilitation for PSD. A total of 202 participants recruited from four centers will be randomized into either the integrative medicine or standard care group. Standard care—basic treatment, general nursing care, and exercise therapy—will be provided to all participants. The integrative medicine group will also receive acupuncture, Chinese herbs, and repeated transcranial magnetic stimulation (rTMS). Participants will receive acupuncture and rTMS treatments five times per week for 4 weeks and will be administered Chinese herbs, basic treatment, general nursing care, and exercise therapy for 4 weeks. The primary outcomes include the Hamilton Depression Scale (HAMD), Self-Rating Depression Scale (SDS), and Activity of Daily Living Scale (ADL). And the secondary outcomes include the Montreal Cognitive Assessment Scale, the Fugl-Meyer Assessment (FMA) Scale, and the Pittsburgh Sleep Quality Index (PSQI). All outcome measures will be evaluated at baseline, week 4 (the end of the treatment courses), and week 8 (the end of follow-up). Safety assessments will be performed throughout the study.DiscussionThis study is expected to verify the efficacy and safety of integrative medicine for treating PSD, providing an evidence-based clinical reference for the future development of a standardized scheme.Clinical trial registrationClinicalTrials.gov, identifier: NCT05187975
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- 2022
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12. The Moxibustion-Induced Thermal Transport Effect Between the Heart and Lung Meridians With Infrared Thermography
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Xiaoyu Li, Yongliang Jiang, Hantong Hu, Jiali Lou, Yajun Zhang, Xiaofen He, Yuanyuan Wu, Junfan Fang, Xiaomei Shao, and Jianqiao Fang
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heart and lung meridians ,site specificity ,infrared thermography ,moxibustion ,thermal transport ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
ObjectivesBy comparing the differences in the thermal transport effect between the heart and lung meridians induced by moxibustion, this study aimed to investigate the specificity of site-to-site associations on the body surface between different meridians.MethodsEighty healthy participants were divided into the heart meridian intervention group and the lung meridian intervention group; moxibustion was performed at these two meridians, respectively. Baseline temperature and its change magnitude from baseline induced by moxibustion in 6 measuring sites of the heart and lung meridians were assessed by infrared thermography (IRT). Measuring sites included: Site 1 (Chize, LU5), Site 2 (midpoint of LU9 and LU5), Site 3 (Taiyuan, LU9), Site 4 (Shaohai, HT3), Site 5 (midpoint of HT7 and HT3), and Site 6 (Shenmen, HT7).ResultsForty participants (20 male and 20 female, 27.90 ± 0.52 years) were assigned to the heart meridian intervention group, and 40 participants (20 male and 20 female, 28.08 ± 0.54 years) were assigned to the lung meridian intervention group. In the lung meridian intervention group (moxibustion over LU5), the temperature of the distal sites in the lung meridian increased significantly at 5, 10, and 15 min compared with pre-moxibustion (P < 0.001). The temperature of Site 4 in the heart meridian, which was nearest to the moxibustion site, increased significantly compared with pre-moxibustion (P < 0.05), while the temperature in the distal sites of the heart meridian did not differ significantly during moxibustion. Regarding the comparison of temperature change magnitude from baseline (ΔT) between the two meridians, the ΔT of Site 2 in the lung meridian was significantly higher than Site 4 in the heart meridian at 5 and 10 min after moxibustion (P < 0.05), despite that Site 2 was more distal from the moxibustion site than Site 4. Similarly, the ΔT of Site 3 in the lung meridian was significantly higher than Site 5 and Site 6 in the heart meridian at 5, 10, and 15 min after moxibustion (P < 0.05). In the heart meridian invervention group, similar thermal transport effect between the two meridians was observed. The thermal transport effect of the distal sites along the heart meridian was more significant than that of the site closer to the moxibustion site but located in the lung meridian. Taken together, aforementioned results indicated that the moxibustion-induced thermal transport effect between the heart and lung meridians is generally more significant in the distal sites along the corresponding meridian than that in the closer sites of the other meridian.ConclusionsIn the heart and lung meridians, the moxibustion-induced thermal transport effect is closely related to meridian routes, not just related to the absolute distance from the moxibustion site, thereby confirming the relative specificity of “site-to-site” associations on the body surface in these two meridians.Systematic Review Registrationhttps://clinicaltrials.gov/ct2/show/NCT05330403, identifier NCT05330403.
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- 2022
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13. Status, reporting completeness and methodological quality of pilot randomised controlled trials in acupuncture: protocol for a systematic review
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Jianqiao Fang, Yajun Zhang, Hantong Hu, Xiaoyu Li, Jiali Lou, Xiaofen He, and Yongliang Jiang
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Medicine - Published
- 2021
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14. Efficacy and Safety of Moxibustion for Postherpetic Neuralgia: A Systematic Review and Meta-Analysis
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Qiqi Wu, Hantong Hu, Dexiong Han, and Hong Gao
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postherpetic neuralgia ,moxibustion ,systematic reveiw ,herpes zoster ,meta-analysis ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Postherpetic neuralgia (PHN) is one of the most common complications of herpes zoster (HZ), and there is still a lack of effective therapies. An increasing number of studies have found that compared to traditional therapy, moxibustion treatment is beneficial for the treatment of PHN, although current evidence remains inconclusive. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the efficacy and safety of moxibustion for PHN.Methods: We conducted a broad literature review of a range of databases from inception to December 2020, including the Cochrane Library, PubMed, EMBASE, Web of Science, Clinical Trails, China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP), China Biomedical Network Information, and Wanfang databases. We included RCTs that compared moxibustion to pharmacological therapies, herbal medicine, or no treatment for treating PHN. The main outcome measure was efficacy rate and Visual Analog Scale (VAS); the secondary outcome measure was adverse events. Data accumulation and synthesis included meta-analysis, publication bias, sensitivity analysis, risk-of-bias assessment, and adverse events.Results: We included 13 RCTs involving 798 patients. Compared with the controls (pharmacological therapies, herbal medicine, or no treatment), moxibustion achieved a significantly higher efficacy rate (odds ratio [OR]: 3.65; 95% [confidence interval]: [2.32, 5.72]; P < 0.00001). Subgroup analysis of the distinct moxibustion modalities showed that both Zhuang medicine medicated thread and thunder-fire moxibustions obtained higher clinical efficacy than the control group. Compared with the controls, moxibustion resulted in significantly lower scores on the VAS (Weighted Mean Difference (MD) = −1.79; 95% CI: [−2.26, −1.33]; P < 0.00001). However, there was no significant difference in terms of safety between moxibustion and the controls (OR = 0.33; 95% CI [0.06, 1.77]; P = 0.19).Conclusion: Due to the lack of methodological quality as well as the significant heterogeneity of the included studies, it remains difficult to draw a firm conclusion on the efficacy and safety of moxibustion for the treatment of PHN. Future high-quality studies are urgently needed.
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- 2021
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15. The Efficacy and Safety of Acupuncture for Prophylaxis of Vestibular Migraine: A Study Protocol for a Randomized Controlled Trial
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Tianye Hu, Hantong Hu, Feng Chen, Bin Jiang, Fengfei Shen, Yingying Su, Mengyi Yang, and Jin Hu
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vestibular migraine ,acupuncture ,prophylaxis ,randomized controlled trial ,protocol ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Introduction: With a high incidence rate and low diagnosis rate, vestibular migraine (VM) can seriously affect the quality of life of patients, but it remains difficult to manage by current treatment options. Acupuncture may be a potential treatment option for VM prophylaxis, but the currently available evidence is still uncertain. Therefore, this trial aims to evaluate the efficacy and safety of acupuncture for VM prophylaxis.Methods: This is a 28-week parallel, randomized, controlled clinical trial including 4 weeks of baseline, 8 weeks of treatment, and 16 weeks of follow-up. A total of 72 participants will be randomly assigned to two groups. The participants will receive acupuncture in the experimental group, while the participants in the control group will be treated with venlafaxine. The primary outcome measures are change in vertigo/migraine days and vertigo/migraine attacks, vertigo severity, and migraine intensity per 4 weeks from baseline. The secondary outcome measures are change in doses of rescue medication, anxiety level, depression level, and quality of life per 4 weeks from baseline. Adverse events will be recorded for safety evaluation.Discussion: This study will investigate the efficacy and safety of acupuncture for VM prophylaxis. The results will contribute to determining whether acupuncture can serve as an optional treatment strategy for treating VM.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT0464088.
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- 2021
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16. Efficacy of Electroacupuncture Therapy in Patients With Postherpetic Neuralgia: Study Protocol for a Multicentre, Randomized, Controlled, Assessor-Blinded Trial
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Hantong Hu, Yejing Shen, Xinwei Li, Hongfang Tian, XingLing Li, Yang Li, Yingying Cheng, Lei Wu, and Dexiong Han
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electroacupuncture ,postherpetic neuralgia ,pain ,randomized controlled trial ,protocol ,Medicine (General) ,R5-920 - Abstract
Introduction: The efficacy of conventional treatments for treating postherpetic neuralgia (PHN) remains unsatisfactory. Thus, this multicentre, randomized controlled, assessor-blinded trial aims to investigate the efficacy and safety of electroacupuncture (EA) therapy in patients with PHN.Methods and Analysis: This multicentre randomized controlled trial will enroll 132 patients with PHN from 3 hospitals. All patients will be randomly assigned to either the EA combined with medication group or medication group through a computerized central randomization system in a 1:1 ratio. Outcome measures will be assessed before intervention, at 2, 4, 6 weeks after intervention and at the end of 8-week follow-up. Primary outcomes will be sensory thresholds and pain intensity. Secondary outcomes will include dosage of analgetic, quality of life, anxiety, and depression severity and sleep quality. All adverse effects will be assessed during the trial.Conclusions: This study will provide evidence to ascertain whether EA is effective and safe for treating PHN.Ethics and Dissemination: Ethics approval (No.ZSLL-KY-2017-025) has been obtained from the Ethics Committee of The Third Affiliated Hospital of Zhejiang Chinese Medical University. Informed consent will be signed prior to subject enrolment. The results will be submitted to international peer-reviewed journals and presented at international conferences.Trial Registration Number: The study protocol has been registered in the clinicaltrials registry with the identification code NCT04594226.
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- 2021
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17. Acupuncture for chronic tinnitus: A CARE-compliant case report
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Luxue, Lin, Tingting, Lin, Lijuan, Fan, Ke, Shen, Hantong, Hu, and Hong, Gao
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Complementary and alternative medicine ,Chiropractics ,General Nursing ,Analysis - Abstract
Tinnitus is a sound hallucination characterised by buzzing and hissing in the ear or brain of a patient in the absence of an externally available sound source. It could be perceived as one or more sounds and can last for a certain period of time.We aimed to report the successful treatment of tinnitus using acupuncture.A patient diagnosed with chronic tinnitus had buzzing sounds in both ears for over 4 years. Acupuncture treatment was administered a total of five times. GV20 (Baihui), EX-HN1 (Sishencong), GV24 (Shenting), CV12 (Zhongwan), CV10 (Xiawan), CV6 (Qihai), CV4 (Guanyuan), and other bilateral acupuncture points, including GB13 (Benshen), SI19 (Tinggong), GB2 (Tinghui), SJ17 (Yifeng), KI19 (Yindu), and KI17 (Shangqu), were selected as acupuncture points.Tinnitus was successfully resolved, and THI scores decreased.Acupuncture is a potential alternative treatment for chronic tinnitus.
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- 2023
18. Acupuncture for treating symptoms associated with chorea-acanthocytosis: A CARE-compliant case report
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Hong Gao, Dexiong Han, Hantong Hu, Yingying Cheng, Jiawei Wang, Qiqi Wu, and Zengtu Li
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Movement disorders ,business.industry ,Choreiform movement ,Chorea ,Zusanli ,medicine.disease ,Atrophy ,Complementary and alternative medicine ,Anesthesia ,Neuroacanthocytosis ,Acupuncture ,medicine ,Chiropractics ,medicine.symptom ,business ,General Nursing ,Analysis ,Chorea acanthocytosis - Abstract
Background: Chorea-acanthocytosis (ChAc) is the most common type of neuroacanthocytosis syndromes. Characteristic movement disorders of ChAc are choreiform movements affecting both trunk and extremities. Acanthocytosis in peripheral blood smear, elevated serum creatine kinase, atrophy of heads of caudate nuclei and dilation of the anterior horn of the lateral ventricles in magnetic resonance imaging could assist the diagnosis of ChAc. Objective: We aimed to report on the use of acupuncture to successfully improve ChAc symptoms. Method: A patient with definite ChAc was admitted, who had suffered from involuntary tongue protrusion for about 10 years. Acupuncture treatment was administrated for 3 times a week for 2 months. The chorea tremor control area, Baihui (GV20), Sishencong (EX-HN1), Shenting (GV24), Benshen (GB13, bilateral), Yintang (GV29), Neiguan (PC6, bilateral), Tongli (HT5, bilateral), Zusanli (ST36, bilateral), Sanyinjiao (SP6, bilateral), Dicang (ST4, bilateral), Chengjiang (CV24), Lianquan (CV23), Jinjin (EX-HN12) and Yuye (EX-HN13) were selected as acupunture points. Results: Previous drug dosage was reduced and the frequency of involuntary tongue protrusion was significantly reduced. Other clinical symptoms were also well controlled. Peripheral blood smear still indicated an increased proportion of red lineage, but blood analyses revealed improvement at follow-up. Conclusions: For patients who do not response well to conventional medical treatments, acupuncture might be used as an alternative treatment for symptoms related to ChAc.
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- 2023
19. Determining the Efficacy and Safety of Acupuncture for the Preventive Treatment of Menstrual Migraine: A Protocol for a PRISMA-Compliant Systematic Review and Meta-Analysis
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Qiqi Wu, Jiawei Wang, Xiaoqi Lin, Dexiong Han, Hantong Hu, and Hong Gao
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Anesthesiology and Pain Medicine ,Journal of Pain Research - Abstract
Qiqi Wu,1,* Jiawei Wang,2,* Xiaoqi Lin,2,* Dexiong Han,3 Hantong Hu,3 Hong Gao3 1Department of Acupuncture, Moxibustion and Massage, Wenzhou Central Hospital, Wenzhou City, Peopleâs Republic of China; 2The Third School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou City, Peopleâs Republic of China; 3Department of Acupuncture and Moxibustion, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Hantong Hu; Hong Gao, Department of Acupuncture and Moxibustion, the Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, Xihu District, Hangzhou City, Peopleâs Republic of China, Email 413351308@qq.com; qtgh@vip.qq.comBackground: Menstrual migraine (MM), as a common type of headache related to womenâs menstrual cycle, currently available treatments do not produce sufficient effectiveness, making it remains difficult to manage. Although acupuncture may be an effective treatment for MM, there is a lack of convincing evidence to recommend acupuncture to patients with MM until more solid evidence is produced. Therefore, the purpose of our systematic review (SR) and meta-analysis protocol is to synthesize up-to-date evidence regarding the clinical efficacy and safety of acupuncture on MM.Methods: To find qualifying RCTs, nine databases will be searched. RevMan 5.3 will be used to combine the retrieved data for meta-analyses. The Cochrane risk of bias instrument will be used to assess the methodological quality of each included trial. The strength and certainty of the evidence will be evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system. Additionally, we will undertake sensitivity analyses, publication bias, and subgroup analyses if available.Discussion: Our SR and meta-analysis protocol will contribute to determining acupunctureâs therapeutic effect and safety in the preventive treatment of MM. Based on the up-to-date evidence produced by the subsequent SR and meta-analysis, informed treatment decisions will be made by patients, physicians and policy makers.Keywords: menstrual migraine, acupuncture, systematic review, meta-analysis
- Published
- 2023
20. The Efficacy and Safety of Acupuncture for Tinnitus-Associated Insomnia: A Protocol for a Systematic Review and Meta-Analysis
- Author
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Lijuan Fan, Yiqi Gao, Jie Zhou, Hantong Hu, and Hong Gao
- Subjects
Anesthesiology and Pain Medicine ,Journal of Pain Research - Abstract
Lijuan Fan,1,* Yiqi Gao,2,* Jie Zhou,3 Hantong Hu,3 Hong Gao3 1The Third Clinical College, Zhejiang Chinese Medical University, Hangzhou City, Peopleâs Republic of China; 2Department of Traditional Therapy Centre, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Peopleâs Republic of China; 3Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Hantong Hu; Hong Gao, Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, Xihu District, Hangzhou City, Peopleâs Republic of China, Email 413351308@qq.com; qtgh@vip.qq.comBackground: Tinnitus accounts for a significant proportion of the factors that cause insomnia, and insomnia, in turn, aggravates tinnitus. Given that tinnitus and insomnia have a bidirectional relationship, tinnitus-associated insomnia is prevalent. Nonetheless, current treatments including medication and psychological therapies for tinnitus-associated insomnia do not yield satisfactory efficacy, thereby making it challenging to manage. Although acupuncture is a potentially effective treatment option, the current evidence on the efficacy and safety of acupuncture for tinnitus-associated insomnia remains inconclusive. Therefore, this systematic review and analysis protocol aims to investigate whether acupuncture is beneficial for tinnitus-associated insomnia with an acceptable safety profile.Methods: Nine mainstream English-language and Chinese-language databases will be searched to include qualified RCTs and meta-analyses will be conducted by combining extracted data using RevMan 5.3. The risk of bias 2.0 tool recommended by Cochrane will be adopted to evaluate the methodological quality of the included RCTs. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach will be utilized to appraise the strength and certainty of evidence. Where available, we will also perform sensitivity analyses, publication bias and subgroup analysis.Discussion: Expected results from our systematic review and meta-analysis will verify the efficacy and safety of acupuncture in tinnitus-associated insomnia. The evidence generated by this review will help patients and clinicians make informed treatment decisions.Keywords: systematic review, meta-analysis, acupuncture, tinnitus, insomnia
- Published
- 2022
21. Acupuncture for Major Depressive Disorder: A Data Mining-Based Literature Study
- Author
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Mingqi Tu, Sangsang Xiong, Shengxia Lv, Xiaoting Wu, Hantong Hu, Renjie Hu, Jianqiao Fang, and Xiaomei Shao
- Subjects
Neuropsychiatric Disease and Treatment - Abstract
Mingqi Tu,1,* Sangsang Xiong,1,* Shengxia Lv,2,* Xiaoting Wu,1 Hantong Hu,3 Renjie Hu,4 Jianqiao Fang,1 Xiaomei Shao1 1Key Laboratory for Research ofAcupuncture Treatment and Transformation of Emotional Diseases, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Peopleâs Republic of China; 2The School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Peopleâs Republic of China; 3The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Peopleâs Republic of China; 4The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Xiaomei Shao, Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, The Third Clinical Medical College, Zhejiang Chinese Medical University, No. 548, Binwen Road, Binjiang District, Hangzhou, Zhejiang Province, Peopleâs Republic of China, Tel +86 189 5713 0287, Email 13185097375@163.comIntroduction: Acupuncture has a long history of treating major depressive disorder (MDD), yet the acupoint selection of acupuncture for MDD varies greatly. This study aimed to explore the characteristics and principles of acupuncture for MDD by analyzing clinical trials of acupuncture for MDD using data mining techniques.Methods: In this study, clinical trials of acupuncture for MDD were retrieved and relevant data were extracted, and then the data were analyzed by data mining techniques. In addition, association rule mining, network analysis and hierarchical cluster analysis were used to determine the correlation between different acupoints.Results: The results revealed that GV20, LR3, PC6, SP6 and GV29 were used most frequently; acupoints in the Yang meridian were used more often than those in the Yin meridian, with the most applied acupoints in the Governor Vessel; the percentage of specific acupoints applied was 69.39%, with the most applied being five-shu points; the frequency of acupoints used was highest in the lower limbs, while the head, face, and neck had the most acupoints used; GV29 combined with GV20 were the most used acupoint groups; the core acupoints used for MDD were GV20, PC6 and SP36; there were 5 acupoint groups according to the cluster analysis. The most used acupuncture method was manual acupuncture; the frequency of treatment was mostly 7 times per week and the duration of treatment was mostly 42 days.Discussion: We discussed the current character of acupuncture treatment on MDD, including the frequency used of acupoints, the property of used acupoints, the acupoint combination, the acupuncture method, and the frequency and duration of treatment. These findings may provide new ideas for the clinical treatment of MDD. However, further clinical/experimental studies are needed to demonstrate the significance of this concept and approach.Keywords: acupuncture treatment, data mining technology, association rule mining, network analysis, cluster analysis
- Published
- 2023
22. Investigating the Therapeutic Effect of Intradermal Acupuncture for Acute Herpes Zoster and Assessing the Feasibility of Infrared Thermography for Early Prediction of Postherpetic Neuralgia: Study Protocol for a Randomized, Sham-Controlled, Clinical Trial
- Author
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Hantong Hu, Yingying Cheng, Lei Wu, Dexiong Han, and Ruijie Ma
- Subjects
Anesthesiology and Pain Medicine ,Journal of Pain Research - Abstract
Hantong Hu,1,2,* Yingying Cheng,1,* Lei Wu,1 Dexiong Han,1,2 Ruijie Ma1,2 1Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Peopleâs Republic of China; 2Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou City, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Ruijie Ma; Dexiong Han, Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou City, Peopleâs Republic of China, Email maria7878@sina.com; han_0213@163.comIntroduction: Herpes zoster (HZ) can adversely influence patientsâ quality of life and sometimes it can develop postherpetic neuralgia (PHN). To date, it remains challenging to be managed by currently available therapies. Intradermal acupuncture (IDA) has the potential to be an adjunctive therapy for acute HZ and infrared thermography (IRT) may be useful for predicting PHN; however, current evidence remains inconclusive. Therefore, the purposes of this trial are to 1) evaluate the efficacy and safety of IDA as an adjunctive therapy for acute HZ; 2) to explore the feasibility of IRT for early prediction of PHN and as an objective tool to aid in subjective pain assessment in acute HZ.Methods: This study is designed as a randomized, parallel-group, sham-controlled, and patient-assessor-blinded trial, including 1-month treatment and 3-month follow-ups. Seventy-two qualified participants will be randomly split into the IDA or sham IDA group in a ratio of 1:1. Apart from standard pharmacological treatments in both groups, the two groups will receive 10 sessions of IDA or sham IDA, respectively. Primary outcome measures are the visual analog scale (VAS), indicators of herpes lesionsâ recovery, the temperature of the pain area, and the incidence rate of PHN. The secondary outcome is the 36-item Short Form Health Survey (SF-36). Indicators of herpes lesionsâ recovery will be assessed at each visit and follow-ups. The remaining outcomes will be assessed at baseline, 1 month after intervention, and 3-month follow-up. Safety evaluation will be determined by adverse events during the trial.Conclusion: Expected results will determine whether IDA can enhance therapeutic effectiveness of pharmacotherapy for acute HZ with acceptable safety profile. In addition, it will verify the accuracy of IRT for early prediction of PHN and as an objective tool of subjective pain for acute HZ.Trial Registration: Clinicaltrials.gov (identification number: NCT05348382; Registered 27 April 2022, https://clinicaltrials.gov/ct2/show/NCT05348382).Keywords: acupuncture, herpes zoster, postherpetic neuralgia, infrared thermography, clinical trial
- Published
- 2023
23. The Central Response of Electroacupuncture on Trigeminal Neuralgia Based on Resting-State Functional Magnetic Resonance Imaging: A Protocol for a Pre-Experimental, Single-Centre, Randomized, Controlled Trial
- Author
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Ping Jin, Hantong Hu, Jianqiao Fang, Ding Tang, Xufen Zhang, Lifang Chen, Huangwei Jiang, Jianlan Sun, Yani Xu, and Linglin Dai
- Subjects
Visual analogue scale ,Electroacupuncture ,medicine.medical_treatment ,law.invention ,Study Protocol ,pre-experimental ,Randomized controlled trial ,Trigeminal neuralgia ,law ,electroacupuncture ,Hamd ,medicine ,protocol ,Journal of Pain Research ,health care economics and organizations ,trigeminal neuralgia ,business.industry ,fMRI ,food and beverages ,Carbamazepine ,medicine.disease ,Resting state functional magnetic resonance imaging ,Single centre ,Anesthesiology and Pain Medicine ,Anesthesia ,randomized controlled trial ,business ,medicine.drug - Abstract
Ding Tang,1 Xufen Zhang,1 Yani Xu,1 Linglin Dai,1 Jianlan Sun,1 Hantong Hu,2 Huangwei Jiang,3 Ping Jin,3 Lifang Chen,2 Jianqiao Fang4 1The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, Peopleâs Republic of China; 2Department of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, Peopleâs Republic of China; 3Department of Radiological, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, Peopleâs Republic of China; 4The Third Clinical Medical College of Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, Zhejiang, Peopleâs Republic of ChinaCorrespondence: Lifang ChenDepartment of Acupuncture, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, Zhejiang, 310005, Peopleâs Republic of ChinaEmail clfang@163.comJianqiao FangZhejiang Chinese Medical University, NO. 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, 310053, Peopleâs Republic of ChinaEmail fangjianqiao7532@163.comObjective: To verify the efficacy of electroacupuncture (EA) on classical trigeminal neuralgia (CTN), and to observe the brain functional status of patients with CTN and the intervention effects of EA on brain function by resting-state functional magnetic resonance imaging (rs-fMRI).Methods and Analysis: Thirty CTN patients will be randomly divided into EA combined with carbamazepine group and carbamazepine group in 2:1 ratio by using a random number table. Patients in EA combined with carbamazepine will receive EA treatment and carbamazepine for four weeks. The carbamazepine group will only receive carbamazepine treatment. VAS (visual analogue scale), HAMA (Hamilton Anxiety Scale), HAMD (Hamilton Depression Scale) and SF-36 (short form 36 health survey) will be performed before, after four-week treatments and at three-month follow-up in CTN patients. Six CTN patients will be randomly selected from EA combined with carbamazepine group and carbamazepine group, respectively, before treatment, and twelve paired healthy participants will be recruited at the same time. The twelve CTN patients will be scanned by rs-fMRI before and after treatment, and the healthy participants will be scanned by rs-fMRI only at baseline. Regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) analysis will be carried out to compare the dysfunctional brain regions between CTN patients and healthy participants, as well as the differences between two groups of patients with CTN after treatment.Trial Registration: ChiCTR-1900027873.Keywords: electroacupuncture, trigeminal neuralgia, pre-experimental, fMRI, randomized controlled trial, protocol
- Published
- 2021
24. Surgical treatment versus non-surgical treatment for Carpal Tunnel Syndrome: A Systematic Review
- Author
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Manting Cao, Hantong Hu, and Jing Chen
- Abstract
Study design: Systematic review. Introduction: Carpal tunnel syndrome (CTS) is a common and painful compressive peripheral neuropathy with complex symptoms, caused by pressure on the median nerve as it travels through the carpal tunnel. Purpose of the Study: This review aimed to develop a critical systematic review of the research evidence to evaluate the effectiveness of non-surgical intervention compared to surgical intervention in the treatment of patients with CTS. Methods: Four electronic databases (PEDro, PubMed/MEDLINE, Cochrane Library, and Web of Science) and two grey literature databases (US ClinicalTrials. gov, and OpenGrey) were used to perform a comprehensive search of the relevant data. Results: A total of 686 potentially related studies were found in the four databases, and no relevant studies were found in the two gray literature databases. 10 studies finally met the inclusion criteria and were included in this review.Five studies compared the effect of local steroid injection and surgical treatment on patients with CTS. Two studies compared manual therapy with surgical treatment.; One study compared splinting with surgical treatments; One study make a comparison between a combined non-surgical treatment program and non-surgical treatment; One study compared the effectiveness of splinting, splinting combined with local steroid injection and surgical treatment. Conclusion:In conclusion, critical analysis of the findings shows that both surgical treatment and non-surgical treatment are effective for the management of patients with CTS. Indeed, surgical treatment shows better effectiveness. Critical analysis of the findings showed that both surgical and non-surgical treatments are effective for the management of patients with CTS. Thus, surgical treatment is more effective.
- Published
- 2022
25. The Efficacy of Integrated Rehabilitation for Post-Stroke Anxiety: Study Protocol for a Prospective, Multicenter, Randomized Controlled Trial
- Author
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Jie Zhou, Lijuan Fan, Hantong Hu, Ke Shen, Liya Wu, Xiaoqi Lin, and Hong Gao
- Subjects
International Journal of General Medicine ,General Medicine - Abstract
Jie Zhou,1,* Lijuan Fan,2,* Hantong Hu,1 Ke Shen,2 Liya Wu,2 Xiaoqi Lin,2 Hong Gao1 1Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Peopleâs Republic of China; 2The Third Clinical College of Zhejiang Chinese Medical University, Hangzhou, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Hong Gao, Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, Hangzhou, Peopleâs Republic of China, Email qtgh@vip.qq.cnBackground: Post-stroke anxiety (PSA) remains a challenging medical problem. Integrated rehabilitation involves a combination of traditional Chinese medicine (TCM) and Western conventional rehabilitation techniques. Theoretically, integrated rehabilitation is likely to have significant advantages in treating PSA. Nevertheless, the therapeutic effect of integrated rehabilitation needs to be verified based on large-scale trials with sound methodology. Thus, the aim of this trial is to assess the efficacy and safety of integrated rehabilitation on PSA.Methods: The study is a prospective, multicenter, randomized, controlled trial involving 188 PSA patients from four clinical centers in China. Eligible participants will be randomly divided into the integrated rehabilitation group or the standard care group. Participants in the integrated rehabilitation group will receive a combination of TCM and Western conventional rehabilitation methods, including acupuncture, repeated transcranial magnetic stimulation, traditional Chinese herbal medicine, and standard care. The primary outcome will be the Hamilton Anxiety Rating Scale (HAM-A). The secondary outcomes will include the Self-Rating Anxiety Scale (SAS), the Activities of Daily Living (ADL) scale, the Montreal Cognitive Assessment (MoCA) scale, the simplified FuglâMeyer Assessment of motor function (FMA) scale, and the Pittsburgh Sleep Quality Index (PSQI). Outcome measurements will be performed at baseline, at the end of the 4-week treatment and the 8-week follow-up.Conclusion: Results of this trial will ascertain the efficacy and safety of integrated rehabilitation on PSA, thereby providing evidence regarding integrated rehabilitation strategies for treating PSA. It will also promote up-to-date evidence for patients, clinicians, and policy-makers.Trial Registration: ClinicalTrials.gov NCT05147077.Keywords: post-stroke anxiety, traditional Chinese medicine, Western medicine, repeated transcranial magnetic stimulation, rehabilitation, randomized controlled trial
- Published
- 2022
26. Letter to the Editor: Acupuncture Based on Regulating Autonomic Nerves for the Prevention of Migraine without Aura: A Prospective, Double-Dummy, Randomized Controlled Clinical Trial [Response to Letter]
- Author
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Chuanlong Zhou, Jie Bao, Hantong Hu, Siting Ye, Xiaomei Shao, Yi Liang, and Jianqiao Fang
- Subjects
Anesthesiology and Pain Medicine ,Journal of Pain Research - Abstract
Chuanlong Zhou,1 Jie Bao,2 Hantong Hu,1 Siting Ye,3 Xiaomei Shao,4 Yi Liang,4 Jianqiao Fang4 1Department of Acupuncture, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 3Department of Tuina, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 4Key Laboratory of Acupuncture and Neurology of Zhejiang Province, the Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, People’s Republic of ChinaCorrespondence: Chuanlong Zhou, Department of Acupuncture, the Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, XiHu District, Hangzhou, 310005, People’s Republic of China, Email zhouchuanlong6255@163.com
- Published
- 2022
27. Acupuncture for hearing loss: a case report
- Author
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Qunya Dong, Yiting Zhang, Qiqi Wu, Hantong Hu, and Hong Gao
- Subjects
Complementary and alternative medicine ,Neurology (clinical) ,General Medicine - Published
- 2022
28. Efficacy and safety of acupuncture and moxibustion for primary tinnitus: A systematic review and meta-analysis
- Author
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Qiqi Wu, Jiawei Wang, Dexiong Han, Hantong Hu, and Hong Gao
- Subjects
Otorhinolaryngology - Published
- 2023
29. The Efficacy and Safety of Acupuncture for Depression-Related Insomnia: Protocol for a Systematic Review and Meta-Analysis
- Author
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Hantong Hu, Zengtu Li, Yingying Cheng, and Hong Gao
- Subjects
Anesthesiology and Pain Medicine ,Journal of Pain Research - Abstract
Hantong Hu,1,2,* Zengtu Li,3,* Yingying Cheng,1,2,* Hong Gao1,2 1Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Peopleâs Republic of China; 2Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou City, Peopleâs Republic of China; 3Department of Massage, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Hong Gao, Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, Xihu District, Hangzhou City, Peopleâs Republic of China, Email qtgh@vip.qq.comBackground: There is a bidirectional relationship between depression and insomnia. Depression-related insomnia is common and remains a challenging medical condition. Although acupuncture might be a potential treatment option and increasing randomized controlled trials (RCTs) have emerged, currently available evidence regarding the effect and safety of acupuncture on depression-related insomnia remains inconclusive. Thus, this protocol aims to systematically synthesize the evidence about the efficacy and safety of acupuncture for depression-related insomnia.Methods and Analysis: Eligible RCTs will be searched in nine representative databases and pooled in meta-analyses using RevMan 5.3. The methodological quality of included studies will be rated by Cochraneâs risk of bias 2.0 tool. The quality of evidence will be appraised using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Subgroup analysis, sensitivity analyses, and publication bias will also be conducted.Discussion: This protocol outlines the planned scope and methodology for an upcoming systematic review meta-analysis, which will critically synthesize the evidence about the efficacy and safety of acupuncture on depression-related insomnia. Findings will shed light on fulfilling evidence gaps and influence evidence-based treatment decisions for clinicians in the treatment of depression-related insomnia.Keywords: acupuncture, depression-related insomnia, systematic review, meta-analysis
- Published
- 2022
30. Acupuncture for abducens nerve palsy after radiochemotherapy: a CARE-compliant case report
- Author
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Yi Huang, Hantong Hu, Kelin He, Xinyun Li, Qinqin Chen, and Ruijie Ma
- Subjects
Complementary and alternative medicine ,Chiropractics ,General Nursing ,Analysis - Abstract
Delayed abducens nerve palsy after chemoradiotherapy for nasopharyngeal carcinoma (NPC) is often accompanied by ocular ischemia and cranial nerve damage, thereby increasing the risk of conventional strabismus surgery. Therefore, patients often prefer conservative treatment. Herein we report a case of acupuncture for delayed abducens nerve palsy after chemoradiotherapy for NPC.A 39-year-old patient who previously received chemotherapy and radiotherapy for NPC developed a unilateral abducens nerve palsy with numbness in the face and stiffness in the neck muscles after six years. Based on magnetic resonance imaging (MRI), medical history, and physical examination, he was diagnosed with abducens nerve palsy after chemoradiotherapy. The acupuncture treatment regimen was mainly based on periocular electroacupuncture, supplemented with wheat grain moxibustion and warming needle moxibustion, which were performed three times a week. After one month with a total of 17 acupuncture sessions, the patient's affected eye abduction function recovered completely. Facial sensory abnormalities and neck stiffness also improved significantly. Follow-up at two months reported no recurrence.Acupuncture may be a conservative treatment option for patients with abducens nerve palsy after chemoradiotherapy.
- Published
- 2022
31. Electroacupuncture Might Promote the Spontaneous Resorption of Lumbar Disc Herniation: A Case Report
- Author
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Quanai Zhang, Zhong Di, Hong Gao, Jianqiao Fang, Hantong Hu, and Bang-Wei Li
- Subjects
medicine.medical_specialty ,Lumbar Vertebrae ,medicine.diagnostic_test ,Electroacupuncture ,business.industry ,medicine.medical_treatment ,Magnetic resonance imaging ,Physical examination ,Intervertebral Disc Degeneration ,Middle Aged ,Magnetic Resonance Imaging ,Resorption ,Surgery ,Conservative treatment ,Lumbar ,Complementary and alternative medicine ,medicine ,Acupuncture ,Humans ,Lumbar disc herniation ,business ,Intervertebral Disc Displacement - Abstract
Although acupuncture is effective in the treatment of lumbar disc herniation (LDH), based on comprehensive literature review, reports of the resorption of large herniated discs in LDH patients treated merely by acupuncture are very rare.A 49-year-old patient presented with distending pain in the left lower limb and numbness on the dorsum of the left foot. Physical examination revealed positive signs associated with mechanical compression by herniated lumbar discs. Magnetic resonance imaging (MRI) at symptom onset confirmed the diagnosis of LDH at L4-L5 and L5-S1. Electroacupuncture was administered on local acupoints combined with distal acupoints. His clinical symptoms gradually improved with time throughout acupuncture treatment, verified by increased Japanese Orthopaedic Association scores. The patient was discharged after a total of 20 acupuncture sessions within 1 month. Follow-up indicated that his symptoms had disappeared completely at 1.5 months after discharge and had not recurred since then. At the 10-month follow-up, MRI re-examination confirmed that the herniated discs had been resorbed significantly.Electroacupuncture could significantly improve clinical symptoms and might promote the spontaneous resorption of herniated discs in LDH patients. Thus, for LDH patients suitable for conservative treatment, electroacupuncture could be a favourable option recommended to patients.Hintergrund: Zwar hat sich die Akupunktur bei der Behandlung der lumbalen Diskushernie (LDH) als wirksam erwiesen, doch gibt es nur sehr wenige Berichte über die Resorption von großen Diskushernien bei LDH-Patienten, die allein mit Akupunktur behandelt wurden. Fallbericht:Ein 49-jähriger Patient stellte sich mit ausstrahlenden Schmerzen im linken Unterschenkel und Taubheitsgefühl am linken Fußrücken vor. Die körperliche Untersuchung ergab positive Zeichen im Zusammenhang mit mechanischer Kompression aufgrund lumbaler Diskushernien. Die zu Beginn der Symptome durchgeführte Magnetresonanztomographie (MRT) bestätigte die Diagnose einer LDH auf Höhe L4-L5 sowie L5-S1. Es erfolgte eine Elektroakupunktur an den lokalen Akupunkturpunkten in Kombination mit distalen Akupunkturpunkten. Unter der Akupunkturbehandlung besserten sich die klinischen Symptome, was durch höhere Werte des Japanese Orthopaedic Association Scores bestätigt wurde. Nach insgesamt 20 Akupunktursitzungen innerhalb eines Monats wurde der Patient entlassen. Die Nachuntersuchungen zeigten, dass seine Symptome eineinhalb Monate nach der Entlassung vollständig verschwunden und danach nicht wieder aufgetreten waren. Bei der Follow-Up-Untersuchung nach 10 Monaten wurde ein erneutes MRT durchgeführt, welches bestätigte, dass es zu einer deutlichen Resorption der Diskushernien gekommen war. Schlussfolgerung:Die Elektroakupunktur kann die klinischen Symptome von LDH-Patienten signifikant verbessern und die Spontanresorption von Diskushernien fördern. Für LDH-Patienten, die sich für eine konservative Therapie eignen, kann die Elektroakupunktur daher eine günstige therapeutische Option sein, die den Patienten empfohlen wird.
- Published
- 2020
32. Research Trends of Acupuncture Therapy on Knee Osteoarthritis from 2010 to 2019: A Bibliometric Analysis
- Author
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Haijuan Zhang, Hantong Hu, Shuning Zhou, Jianqiao Fang, Jing Sun, Ruohan Sun, Rongrong Li, and Qifei Zhang
- Subjects
medicine.medical_specialty ,Bibliometric analysis ,business.industry ,Osteoarthritis ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,030202 anesthesiology ,Physical therapy ,Acupuncture therapy ,Acupuncture ,Medicine ,business ,030217 neurology & neurosurgery - Abstract
Background Acupuncture has been widely applied to relieve knee osteoarthritis (KOA) in many countries. However, the bibliometric analysis of the global use of acupuncture on KOA is largely unknown. Therefore, this study aimed to explore the current status and trends of the global use of acupuncture on KOA in recent 10 years by using CiteSpace (5.6.R3).
- Published
- 2020
33. Status, reporting completeness and methodological quality of pilot randomised controlled trials in acupuncture: protocol for a systematic review
- Author
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Yongliang Jiang, Jianqiao Fang, Yajun Zhang, Xiaofen He, Hantong Hu, Xiaoyu Li, and Jiali Lou
- Subjects
medicine.medical_specialty ,protocols & guidelines ,statistics & research methods ,Acupuncture Therapy ,Pilot Projects ,Cochrane Library ,Bias ,Secondary analysis ,medicine ,Acupuncture ,Humans ,Medical physics ,Methodological quality ,Randomized Controlled Trials as Topic ,Protocol (science) ,clinical trials ,business.industry ,Consolidated Standards of Reporting Trials ,General Medicine ,Knowledge infrastructure ,Reference Standards ,Clinical trial ,Complementary Medicine ,Medicine ,business ,Systematic Reviews as Topic - Abstract
IntroductionTo date, there has been a lack of knowledge about the status, reporting completeness and methodological quality of pilot trials in the acupuncture field. Thus, this systematic review protocol aims to: (1) investigate publication trends and aspects of feasibility evaluated in acupuncture pilot trials; (2) identify the proportion of acupuncture pilot trials that lead to definitive trials and (3) assess the reporting completeness and methodological quality of pilot trials in acupuncture.Methods and analysisStudies of acupuncture pilot randomised controlled trials published from 2011 to 2021 will be retrieved in seven databases in January 2022, including PubMed, Web of Science, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang Database and Chinese Biomedical Literature Database. The methodological quality and reporting completeness of all included studies will be assessed using the risk of bias 2.0 tool (RoB 2) and the Consolidated Standards of Reporting Trials (CONSORT) extension to randomised pilot and feasibility trials, respectively. For the primary analysis, publication trends, aspects of feasibility and the proportion of pilot trials that lead to definitive trials will be analysed. A quantitative analysis of the methodological quality and reporting completeness of the included trials will be implemented by calculating the percentage of items reported in each domain of RoB 2 and CONSORT. The secondary analysis will adopt a regression analysis to identify factors associated with the reporting completeness.Ethics and disseminationEthical approval is not required for this study. This study is planned to be submitted to a peer-reviewed academic journal.
- Published
- 2021
34. Potential Value of Electroacupuncture in Alleviating Tinnitus
- Author
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Hantong Hu and Hong Gao
- Subjects
Tinnitus ,Electroacupuncture ,Anesthesiology and Pain Medicine ,Neurology ,Acupuncture Therapy ,Humans ,Neurology (clinical) ,General Medicine - Published
- 2022
35. Efficacy and Safety of Moxibustion for Postherpetic Neuralgia: A Systematic Review and Meta-Analysis
- Author
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Dexiong Han, Hantong Hu, Hong Gao, and Qiqi Wu
- Subjects
medicine.medical_specialty ,Visual analogue scale ,medicine.medical_treatment ,herpes zoster ,Subgroup analysis ,moxibustion ,Moxibustion ,systematic reveiw ,Cochrane Library ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,Medicine ,RC346-429 ,postherpetic neuralgia ,business.industry ,Postherpetic neuralgia ,Publication bias ,medicine.disease ,meta-analysis ,Neurology ,Meta-analysis ,Systematic Review ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,business - Abstract
Background: Postherpetic neuralgia (PHN) is one of the most common complications of herpes zoster (HZ), and there is still a lack of effective therapies. An increasing number of studies have found that compared to traditional therapy, moxibustion treatment is beneficial for the treatment of PHN, although current evidence remains inconclusive. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the efficacy and safety of moxibustion for PHN.Methods: We conducted a broad literature review of a range of databases from inception to December 2020, including the Cochrane Library, PubMed, EMBASE, Web of Science, Clinical Trails, China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP), China Biomedical Network Information, and Wanfang databases. We included RCTs that compared moxibustion to pharmacological therapies, herbal medicine, or no treatment for treating PHN. The main outcome measure was efficacy rate and Visual Analog Scale (VAS); the secondary outcome measure was adverse events. Data accumulation and synthesis included meta-analysis, publication bias, sensitivity analysis, risk-of-bias assessment, and adverse events.Results: We included 13 RCTs involving 798 patients. Compared with the controls (pharmacological therapies, herbal medicine, or no treatment), moxibustion achieved a significantly higher efficacy rate (odds ratio [OR]: 3.65; 95% [confidence interval]: [2.32, 5.72]; P < 0.00001). Subgroup analysis of the distinct moxibustion modalities showed that both Zhuang medicine medicated thread and thunder-fire moxibustions obtained higher clinical efficacy than the control group. Compared with the controls, moxibustion resulted in significantly lower scores on the VAS (Weighted Mean Difference (MD) = −1.79; 95% CI: [−2.26, −1.33]; P < 0.00001). However, there was no significant difference in terms of safety between moxibustion and the controls (OR = 0.33; 95% CI [0.06, 1.77]; P = 0.19).Conclusion: Due to the lack of methodological quality as well as the significant heterogeneity of the included studies, it remains difficult to draw a firm conclusion on the efficacy and safety of moxibustion for the treatment of PHN. Future high-quality studies are urgently needed.
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- 2021
36. Comment on: Transcutaneous electrical acupoint stimulation before surgery reduces chronic pain after mastectomy: A randomized clinical trial
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Hantong Hu, Zengtu Li, Hong Gao, and Yajun Zhang
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,MEDLINE ,Chronic pain ,Stimulation ,Breast Neoplasms ,medicine.disease ,Surgery ,law.invention ,Anesthesiology and Pain Medicine ,Randomized controlled trial ,law ,Anesthesia ,Transcutaneous Electric Nerve Stimulation ,Medicine ,Humans ,Female ,Chronic Pain ,business ,Acupuncture Points ,Mastectomy - Published
- 2021
37. The Influence of Age on Blood Flow and Temperature of Acupuncture Points: A Study based on Laser Doppler Flowmetry and Infrared Thermography
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Yajun Zhang, Xiaoyu Li, Xiaofen He, Yongliang Jiang, Hantong Hu, Jiali Lou, Ruijie Ma, Yi Liang, Xiaomei Shao, and Jianqiao Fang
- Published
- 2022
38. The Efficacy and Safety of Acupuncture for Prophylaxis of Vestibular Migraine: A Study Protocol for a Randomized Controlled Trial
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Jin Hu, Mengyi Yang, Fengfei Shen, Bin Jiang, Tianye Hu, Feng Chen, Hantong Hu, and Yingying Su
- Subjects
medicine.medical_specialty ,Venlafaxine ,vestibular migraine ,law.invention ,Study Protocol ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Randomized controlled trial ,law ,Vertigo ,medicine ,Acupuncture ,protocol ,030212 general & internal medicine ,RC346-429 ,Adverse effect ,biology ,business.industry ,biology.organism_classification ,medicine.disease ,Clinical trial ,Neurology ,Migraine ,randomized controlled trial ,Physical therapy ,prophylaxis ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,business ,acupuncture ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Introduction:With a high incidence rate and low diagnosis rate, vestibular migraine (VM) can seriously affect the quality of life of patients, but it remains difficult to manage by current treatment options. Acupuncture may be a potential treatment option for VM prophylaxis, but the currently available evidence is still uncertain. Therefore, this trial aims to evaluate the efficacy and safety of acupuncture for VM prophylaxis.Methods:This is a 28-week parallel, randomized, controlled clinical trial including 4 weeks of baseline, 8 weeks of treatment, and 16 weeks of follow-up. A total of 72 participants will be randomly assigned to two groups. The participants will receive acupuncture in the experimental group, while the participants in the control group will be treated with venlafaxine. The primary outcome measures are change in vertigo/migraine days and vertigo/migraine attacks, vertigo severity, and migraine intensity per 4 weeks from baseline. The secondary outcome measures are change in doses of rescue medication, anxiety level, depression level, and quality of life per 4 weeks from baseline. Adverse events will be recorded for safety evaluation.Discussion:This study will investigate the efficacy and safety of acupuncture for VM prophylaxis. The results will contribute to determining whether acupuncture can serve as an optional treatment strategy for treating VM.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT0464088.
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- 2021
39. Acupuncture for Tourette syndrome: a case report
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Yajun Zhang, Hong Gao, Qiqi Wu, Dexiong Han, and Hantong Hu
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Pediatrics ,medicine.medical_specialty ,Complementary and alternative medicine ,business.industry ,Acupuncture ,Medicine ,Neurology (clinical) ,General Medicine ,business ,medicine.disease ,Tourette syndrome - Published
- 2021
40. The difference in heat transport characteristics of the heart and lung meridians
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Yongliang Jiang, Xiaofen He, Yajun Zhang, Hantong Hu, Jianqiao Fang, Yuanyuan Wu, Jing Sun, Junfan Fang, Xiaomei Shao, Xiaoyu Li, and Jiali Lou
- Subjects
Adult ,Male ,medicine.medical_specialty ,Hot Temperature ,genetic structures ,Copd patients ,medicine.medical_treatment ,site specificity ,Moxibustion ,chronic obstructive pulmonary disease ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,0302 clinical medicine ,fluids and secretions ,Study Protocol Clinical Trial ,Internal medicine ,Acupuncture ,Humans ,Medicine ,030212 general & internal medicine ,Lung ,Aged ,COPD ,business.industry ,Myocardium ,Therapeutic effect ,Healthy subjects ,Biological Transport ,Heart ,General Medicine ,Middle Aged ,medicine.disease ,eye diseases ,medicine.anatomical_structure ,Thermography ,Case-Control Studies ,030220 oncology & carcinogenesis ,infrared thermography ,Female ,Meridian (astronomy) ,meridians ,business ,Research Article - Abstract
Background: The vast majority of previous studies focused on the relationship between 1 meridian and 1 organ, and the comparison and specificity between 2 meridians is rarely explored. Thus, the aim of this study is to compare the heat transport characteristics between 2 different meridians and the specificity between them will also be investigated. Methods: The Lung and Heart meridians are chosen for comparison of 2 different meridians. We will enroll 120 subjects and divide them into the healthy control group, chronic obstructive pulmonary disease (COPD) group and healthy intervention group, in a 1:1:1 ratio. Infrared thermography (IRT) will be used to assess the heat transport characteristics of the Heart and Lung meridians. The specificity for the meridian-visceral association will be investigated by comparing the difference in heat transport characteristic between the Heart and Lung meridians in the healthy control group and COPD group. Meanwhile, moxibustion will be given to subjects in the Heart meridian and Lung meridian respectively in the healthy intervention group to verify the specificity for the surface-surface association. Results: The primary outcomes will be the temperature of corresponding sites along the Heart and Lung meridians. Conclusion: This study will verify the specificity between different meridians by comparing the difference in heat transport characteristic. The findings will guide the selection of acupoints to optimize the therapeutic effect of acupuncture and help determine whether IRT could be used to assist in the diagnosis of COPD. Ethics and dissemination: The study has been approved by the Third Affiliated Hospital of Zhejiang Chinese Medical University (Approval No. ZSLL-KY-2019-001G-01). Trial registration numbers: NCT04046588.
- Published
- 2021
41. In Reply: Research Trends of Acupuncture Therapy on Knee Osteoarthritis from 2010 to 2019: A Bibliometric Analysis (Letter from Luo et al) [Response To Letter]
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Hantong Hu, Jianqiao Fang, and Rongrong Li
- Subjects
medicine.medical_specialty ,Anesthesiology and Pain Medicine ,Bibliometric analysis ,business.industry ,MEDLINE ,Acupuncture therapy ,medicine ,Physical therapy ,Osteoarthritis ,Response to Letter ,Journal of Pain Research ,medicine.disease ,business - Abstract
Rongrong Li,1,* Hantong Hu,1,2,* Jianqiao Fang1,2 1The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People’s Republic of China; 2The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianqiao FangZhejiang Chinese Medical University, 548 Binwen Road, Hangzhou, Zhejiang 310053, People’s Republic of ChinaTel/Fax +86 571-87238254Email fangjianqiao7532@163.com First of all, we appreciate the Editor-in-Chief for giving us the opportunity torespond to comments from Luo et al. Meanwhile, we also express our gratitudeto Luo et al for their attention on our study entitled “Research Trends ofAcupuncture Therapy on Knee Osteoarthritis from 2010 to 2019: A BibliometricAnalysis”.1 Regarding the comments raised by Luo et al, hereby we providea point-by-point response from the following aspects. View the original paper by Li and colleagues This is in response to the Letter to the Editor
- Published
- 2021
42. Difference in Moxibustion-Induced Microcirculatory Responses between the Heart and Lung Meridians Assessed by Laser Doppler Flowmetry
- Author
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Xiaoyu Li, Xiaomei Shao, Yuanyuan Wu, Yongliang Jiang, Jianqiao Fang, Hantong Hu, Yajun Zhang, Jiali Lou, and Xiaofen He
- Subjects
medicine.medical_specialty ,Lung ,genetic structures ,Article Subject ,business.industry ,medicine.medical_treatment ,Significant difference ,Distal site ,Moxibustion ,Laser Doppler velocimetry ,eye diseases ,Other systems of medicine ,medicine.anatomical_structure ,Primary outcome ,fluids and secretions ,Complementary and alternative medicine ,Internal medicine ,medicine ,Cardiology ,Meridian (astronomy) ,business ,Perfusion ,RZ201-999 ,Research Article - Abstract
Objective. By comparing the differences in microcirculatory responses of the heart and lung meridians induced by moxibustion on these two meridians, respectively, this study aimed to investigate the specificity for site-to-site association on body surface between different meridians. Methods. Eighty healthy adults were enrolled and divided into the lung meridian intervention group and heart meridian intervention group in a ratio of 1 : 1. Three-channel laser Doppler flowmetry was used to monitor microcirculatory responses for the heart and lung meridians. Primary outcome was change of blood perfusion units (PU) of three measurement sites along the two meridians. Results. In the lung meridian intervention group, following moxibustion performed at LU5 of the lung meridian, PU in the distal site of the lung meridian increased significantly. By contrast, the PU of HT3 in the heart meridian, which was nearest to the moxibustion site, did not change significantly. PU in the distal site of the heart meridian declined. Meanwhile, significant difference in PU change was detected between the distal site of the lung meridian and the other two control sites of the heart meridians during moxibustion and postmoxibustion. Alternatively, similar to the results of the lung meridian intervention group, the specificity of microcirculatory response between the heart and lung meridians was observed in the heart meridian intervention group. Conclusions. For the heart and lung meridians, the effect of moxibustion-induced microcirculatory response may be more related to meridian routes than the specific distance between two sites located at different meridians, thereby supporting possible specificity for site-to-site association on the body surface between these two meridians. Nevertheless, given that only two meridians and limited measurement sites were compared, all current findings are not sufficiently robust. Further research should be conducted to investigate more meridians and measurement sites.
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- 2021
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- View/download PDF
43. Difference in the metabolic characteristics of chronic obstructive pulmonary disease patients and healthy adults
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Jianqiao Fang, Xiaoyu Li, Jiali Lou, Xiaomei Shao, Hantong Hu, Yuanyuan Wu, Yongliang Jiang, Yajun Zhang, and Xiaofen He
- Subjects
Male ,genetic structures ,Spectrophotometry, Infrared ,medicine.medical_treatment ,oxygenation metabolism ,Pulmonary Disease, Chronic Obstructive ,fluids and secretions ,0302 clinical medicine ,Study Protocol Clinical Trial ,Outcome Assessment, Health Care ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Lung ,COPD ,functional near infrared spectroscopy ,Heart ,General Medicine ,Middle Aged ,Healthy Volunteers ,Cardiovascular physiology ,medicine.anatomical_structure ,Meridian (perimetry, visual field) ,030220 oncology & carcinogenesis ,Cardiology ,Female ,Research Article ,Adult ,medicine.medical_specialty ,Moxibustion ,Meridians ,Sensitivity and Specificity ,chronic obstructive pulmonary disease ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Aged ,business.industry ,Case-control study ,medicine.disease ,eye diseases ,respiratory tract diseases ,Clinical trial ,Oxygen ,Case-Control Studies ,business ,Acupuncture Points - Abstract
Introduction: By detecting the metabolic difference of the Heart and Lung meridians, the present study aims to investigate the specificity of different meridians and verify whether functional near infrared spectroscopy is validated as an add-on technique to assist diagnosis of chronic obstructive pulmonary disease (COPD). Methods and analysis: The Lung and Heart meridians are chosen as the target for comparison; accordingly, 120 eligible participants will be included and divided into the COPD group, healthy control group, and healthy intervention group. Functional near infrared spectroscopy will be adopted to measure the metabolic characteristics of the Heart and Lung meridians. On one hand, the specificity of the meridian-visceral association will be investigated by comparing the metabolic difference in the Heart and Lung meridians between the healthy control group and COPD group. On the other hand, the specificity of site-to-site association will be determined by comparing the metabolic change between the 2 meridians that induced by moxibustion in the Heart meridian and Lung meridian, respectively, in the healthy control group. The primary outcome will be regional oxygen saturation of corresponding regions along the Heart and Lung meridians. Trial registration: ClinicalTrials.gov NCT04046666.
- Published
- 2020
44. Auricular Therapy for Treating Phantom Limb Pain Accompanied by Jumping Residual Limb: A Short Review and Case Study
- Author
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Xingling Li, De-Xiong Han, Qin Guo, Hongfang Tian, Hantong Hu, Yang Li, and Jing Liu
- Subjects
Involuntary movement ,medicine.medical_specialty ,Movement disorders ,business.industry ,Pain medicine ,medicine.medical_treatment ,Phantom limb pain ,medicine.disease_cause ,Surgery ,body regions ,Anesthesiology and Pain Medicine ,Jumping ,Amputation ,medicine ,Neurology (clinical) ,medicine.symptom ,Complication ,business ,Residual limb - Abstract
Phantom limb pain (PLP) is a common complaint among patients after amputation, while jumping residual limb is a rare post-amputation complication, they rarely happen at the same time and both remain difficult to manage. At present, there is a paucity of literature on this topic, and no treatment has been proven effective for treating both of them. In the present brief report, we described a patient who developed severe PLP accompanied by jumping residual limb after below-the-knee amputation and she was treated by auricular therapy (AT) with satisfactory effect.
- Published
- 2020
45. Effect of herb-partitioned moxibustion on pain and quality of life in women with endometriosis: a protocol for a randomized clinical trial
- Author
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Hantong, Hu, Lifang, Chen, Xiaofei, Jin, Ru, Li, and Jianqiao, Fang
- Subjects
Adult ,Young Adult ,Adolescent ,Clinical Protocols ,Moxibustion ,Endometriosis ,Quality of Life ,Humans ,Female ,Middle Aged ,Acupuncture Points ,Pain Measurement - Abstract
To investigate the effect of herb-partitioned moxibustion (HPM) on pain and quality of life in women with endometriosis.Thirty-six patients will be randomly assigned to a treatment group or a wait-list control group. The treatment group will receive 12 sessions of HPM in the lower abdomen and lumbosacral region for 3 months. Wait-list participants will not receive any specific treatments until the trial is completed.The primary outcome measure is pain intensity assessed by a Visual Analogue Scale at baseline, months 1, 2, and 3 in the treatment period, and months 4, 5, and 6 in the follow-up period. Secondary outcome measures include quality of life assessed by the Short Form 36 Health Survey, change in CA125, change in cyst diameter (assessed by ultrasound examination), and rescue medication dosage.This study will provide evidence to confirm if HPM may be used as a therapeutic option for treating endometriosis.
- Published
- 2020
46. Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg
- Author
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Pan Pan, Wen-Hua Ning, Meng-Xiong Zhao, Li Li, Shu Wang, Hantong Hu, Yang Wang, Lili Zhang, and Bao-Yu Zhang
- Subjects
medicine.medical_specialty ,Article Subject ,Electroacupuncture ,medicine.medical_treatment ,chemical and pharmacologic phenomena ,030204 cardiovascular system & hematology ,Flow cytometry ,03 medical and health sciences ,Other systems of medicine ,0302 clinical medicine ,Immune system ,Downregulation and upregulation ,RAR-related orphan receptor gamma ,Internal medicine ,medicine ,030304 developmental biology ,0303 health sciences ,medicine.diagnostic_test ,business.industry ,FOXP3 ,hemic and immune systems ,Blood pressure ,Endocrinology ,Complementary and alternative medicine ,Electroacupuncture Therapy ,business ,RZ201-999 ,Research Article - Abstract
The present study investigated the effects of electroacupuncture on blood pressure in spontaneously hypertensive rats (SHRs) by regulating the immune balance of T helper 17 cells (Th17 cells) and regulatory T cells (Treg cells). This study investigated the role of electroacupuncture in the immune balance of SHRs using Western blot, flow cytometry, and ELISA techniques. Electroacupuncture significantly improved blood pressure, downregulated the expression of RORγt, and upregulated the expression of Foxp3, reduced the production of Th17 cells, promoted the production of Treg cells, reduced the secretion of IL-6 and IL-17, and increased the secretion of TGF-β1 and IL-10. These findings suggest that electroacupuncture therapy effectively improved the systolic blood pressure of SHRs, and its mechanism may be related to promotion of the immune balance between Th17 and Treg.
- Published
- 2020
47. Intrarater and Interrater Reliability of Infrared Image Analysis of Forearm Acupoints before and after Moxibustion
- Author
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Jianqiao Fang, Yajun Zhang, Yongliang Jiang, Hantong Hu, Xiaoyu Li, and Jiali Lou
- Subjects
Infrared image ,Article Subject ,business.industry ,Intraclass correlation ,medicine.medical_treatment ,Intra-rater reliability ,Moxibustion ,Other systems of medicine ,Inter-rater reliability ,medicine.anatomical_structure ,Complementary and alternative medicine ,Forearm ,Thermography ,Medicine ,business ,Nuclear medicine ,RZ201-999 ,Research Article - Abstract
The objective of this study was to determine the intrarater and interrater reliabilities of infrared image analysis of forearm acupoints before and after moxibustion. In this work, infrared images of acupoints in the forearm of 20 volunteers (M/F, 10/10) were collected prior to and after moxibustion by infrared thermography (IRT). Two trained raters performed the analysis of infrared images in two different periods at a one-week interval. The intraclass correlation coefficient (ICC) was calculated to determine the intrarater and interrater reliabilities. With regard to the intrarater reliability, ICC values were between 0.758 and 0.994 (substantial to excellent). For the interrater reliability, ICC values ranged from 0.707 to 0.964 (moderate to excellent). Given that the intrarater and interrater reliability levels show excellent concordance, IRT could be a reliable tool to monitor the temperature change of forearm acupoints induced by moxibustion.
- Published
- 2020
- Full Text
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48. Acupuncture for treating chronic stable angina pectoris associated anxiety and depression: A systematic review and meta-analysis
- Author
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Yongliang Jiang, Binjun Liao, Jie Yu, Jianqiao Fang, Hantong Hu, Mingqi Tu, and Xiaofen He
- Subjects
medicine.medical_specialty ,Depression ,business.industry ,Acupuncture Therapy ,Anxiety ,Cochrane Library ,Anxiety Disorders ,law.invention ,Clinical trial ,Complementary and alternative medicine ,Randomized controlled trial ,law ,Meta-analysis ,Physical therapy ,Acupuncture ,Humans ,Medicine ,Angina, Stable ,medicine.symptom ,Ischemic chest pain ,business ,Depression (differential diagnoses) - Abstract
Background and objective Despite that acupuncture is effective in treating anxiety, depression and chronic stable angina pectoris (CSAP), it remains unclear whether acupuncture can treat CSAP, anxiety and depression simultaneously. This systematic review and meta-analysis aimed to investigate the efficacy of acupuncture on CSAP-associated anxiety and depression. Methods Eight electronic databases were searched to identify eligible randomized controlled trials (RCTs) or controlled clinical trials (i.e. “acupuncture alone or combined with standard care” versus " sham acupuncture alone, sham acupuncture with standard care, or standard care alone”) from their inception to January 2021, which included PubMed, Embase, Web of Science, the Cochrane Library, CBM, CNKI, VIP and Wanfang Database. Data were extracted and meta analyses were performed using the RevMan 5.3. Risk of bias (ROB) 2.0 was used for methodological quality assessment. GRADEprofiler 3.2.2 was used to rate the quality of evidence. Results Seven trials involving 893 subjects were included. Meta-analysis results showed that acupuncture combined with standard care was more effective in relieving anxiety and depression, reducing angina attack frequency, and angina pain intensity than sham acupuncture with standard care and standard care alone. In addition, the effect remained until 16 weeks after acupuncture. The safety of acupuncture for CSAP-associated anxiety and depression was also high. Nonetheless, the quality of evidence ranged from low to moderate. Conclusion Acupuncture may be used as an adjunctive therapy to treat CSAP-associated anxiety and depression. However, more high-quality RCTs are required to confirm our findings.
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- 2021
49. Establishment of appropriate sham acupuncture and successful patient blinding
- Author
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Hong Gao, Tianye Hu, Dexiong Han, and Hantong Hu
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Blinding ,Complementary and alternative medicine ,business.industry ,Anesthesia ,Acupuncture ,MEDLINE ,Medicine ,Sham acupuncture ,Neurology (clinical) ,General Medicine ,business - Published
- 2020
50. [Analysis on the dominant diseases treated with spreading moxibustion therapy based on randomized controlled trials]
- Author
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Hantong, Hu, Bangwei, Li, Tianye, Hu, Chao, Wang, and Hong, Gao
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Dysmenorrhea ,Moxibustion ,Acupuncture Therapy ,Humans ,Female ,Spondylitis, Ankylosing ,Randomized Controlled Trials as Topic - Abstract
To analyze the indications and dominant diseases of the spreading moxibustion therapy.By retrieving 7 databases of both Chinese and English version, such as CNKI, WANFANG, VIP and PubMed, the eligible articles of randomized controlled trials (RCTs) treated with spreading moxibustion therapy were collected. The number of annual publications, the number of each disease system, the indications and dominant diseases involved in the related articles were analyzed statistically, as well as the number of cases and the corresponding clinical effective rates.A total of 182 articles were included, including 40 indications for the spreading moxibustion and covering 9 major disease systems. Specially, the indications in the motor system were maximal in number, accounting for 17.50% (7/40) of the total number of indications. The number of indications in the digestive system was on the second top, accounting for 15.00% (6/40). The dominant diseases were mainly distributed in motor system, respiratory system, nervous system and gynecological system. There were 3 dominant diseases in motor system, i.e. ankylosing spondylitis, back pain and rheumatoid arthritis; 1 dominant disease, i.e. chronic obstructive pulmonary disease in the respiratory system, 1 dominant disease, i.e. primary dysmenorrheal in the gynecological system and 1 dominant disease, i.e. post-stroke paralysis in the nervous system.At present, the indications of the spreading moxibustion therapy are widely distributed and the dominant diseases are concentrated, representatively by ankylosing spondylitis. But, the indications and the dominant diseases of spreading moxibustion are changeable dynamically and the disease spectrum of spreading moxibustion needs to be further explored.
- Published
- 2019
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