387 results on '"Haining, W. Nicholas"'
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2. In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
3. Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine
4. Maintenance of CD4 T cell fitness through regulation of Foxo1
5. Abstract B070: Logic-gated CAR T cell product AB-1015 response to ovarian cancer models with heterogeneous levels of ALPG/P antigen
6. Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
7. Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
8. Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity
9. The epigenetic landscape of T cell exhaustion
10. Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation.
11. X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
12. Constellation Map: Downstream visualization and interpretation of gene set enrichment results
13. Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling
14. Defining ‘T cell exhaustion’
15. PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity
16. Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells
17. Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
18. Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
19. CD28 costimulation regulates genome-wide effects on alternative splicing.
20. Abstract 1783: High-throughput arrayed screening of logic-gated CARs enables the selection of candidates for ccRCC with optimal potency and fidelity traits
21. Abstract 4088: A neovasculature-inducible CA9 CAR resistant to FASL and TGFb mediated suppression for the treatment of ccRCC
22. Abstract 1768: Multiplexed shRNA cassettes targeting orthogonal pathways (FAS/PTPN2/TGFBR) enhance the potency of integrated circuit T cells (ICTs) in multiple solid tumor models
23. Abstract 4073: Tunable STAT activation by synthetic pathway activators (SPAs) increases engineered T-cell potency and persistence
24. Abstract 1794: Targeting mammalian SWI/SNF chromatin remodeling complexes to improve T cell-based cancer immunotherapies
25. Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
26. Supplementary Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
27. Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
28. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
29. Supplementary Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
30. Supplementary Tables 1-3 from Gene Expression Profiling Identifies BAX-δ as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
31. Stable inhibitory activity of regulatory T cells requires the transcription factor Helios
32. A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system
33. When Cancer Cells Become the Enablers of an Antitumor Immune Response
34. c-Maf in CD4+ T cells: it’s all about context
35. Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection
36. Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8⁺ T-cell effector differentiation
37. Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
38. Author Correction: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
39. Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion
40. Normalizing the environment recapitulates adult human immune traits in laboratory mice
41. Abstract 585: AB-1015, a novel integrated circuit T cells containing an ALPG/MSLN logic gate and FAS/PTPN2 shRNA-miR, demonstrates specific and potent activity against ALPG/MSLN tumors
42. Abstract 2840: Identification of a safe harbor CRISPR-Cas9 integration site for improved cell therapy safety and potency
43. Abstract 3610: In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
44. Abstract 2830: Multiplexed shRNAs targeting FAS and PTPN2 enhance CAR T persistence and anti-tumor efficacy
45. Abstract 2854: Logic gates controlled by priming receptors increase specificity and potency of CAR T cells
46. Retention of epigenetic and transcriptional memory among reprogrammed T cells (T-iPSCs) imparts selective advantage for T cell re-differentiation.
47. Immunotherapy for Human Cancer : Evidence and Obstacles
48. Viewing Transplantation Immunology Through Today's Lens: New Models, New Imaging, and New Insights
49. Travels in time: Assessing the functional complexity of T cells
50. PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
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