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8 results on '"Habes, Q.L.M."'

2. The gut in critical illness

Author

Pickkers, P., Kox, M., Habes, Q.L.M., Pickkers, P., Kox, M., and Habes, Q.L.M.

Abstract

Radboud University, 04 november 2022, Promotor : Pickkers, P. Co-promotor : Kox, M., Contains fulltext : 283415.pdf (Publisher’s version ) (Open Access)

Published
2022

3. The gut in critical illness.

Author

Habes, Q.L.M. and Habes, Q.L.M.

Subjects
Radboud Institute for Molecular Life Sciences., Radboudumc 4: lnfectious Diseases and Global Health., Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences.
Published
2022

6. [When enteral nutrition is not possible in intensive care patients: whether to wait or use parenteral nutrition?]

Author

Habes, Q.L.M. and Pickkers, P.

Subjects
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Abstract

Item does not contain fulltext - Overfeeding of critically ill patients is associated with a higher incidence of infections and an increased length of ventilation. However, trophic nutrition or permissive underfeeding appears to have no negative effect on the patient and may even provide a survival benefit.- Initiation of enteral nutrition within 24-48 hours after Intensive Care Unit (ICU) admission may reduce the number of complications and increase the chance of survival.- Total parenteral nutrition is associated with a higher risk of infections than enteral nutrition. This seems to be related to the higher calorie intake with parenteral nutrition rather than the route of administration.- In previously well-nourished patients, in whom enteral nutrition is only partially successful, it is safe to wait for up to 8 days before initiating supplemental parenteral nutrition.- In critically ill children, it is also safe to start supplemental parenteral nutrition at a late (on the 8th day after admission) rather than an early stage (within 24 hours of admission). Late supplemental parenteral nutrition may even result in fewer infectious complications and shorter hospitalisation.

Published
2016

7. Markers of Intestinal Damage and their Relation to Cytokine Levels in Cardiac Surgery Patients

Author

Habes, Q.L.M., Linssen, V., Nooijen, S., Kiers, D., Gerretsen, J., Pickkers, P., Scheffer, G.J., Kox, M., Habes, Q.L.M., Linssen, V., Nooijen, S., Kiers, D., Gerretsen, J., Pickkers, P., Scheffer, G.J., and Kox, M.

Abstract

Contains fulltext : 175623.pdf (publisher's version ) (Closed access), OBJECTIVES: In patients undergoing cardiac surgery, both extracorporeal circulation (ECC) and intraoperative mesenterial hypoperfusion may account for increased cytokine levels and lead to postoperative gastrointestinal (GI) symptoms. METHODS: We investigated levels of the intestinal damage markers intestinal fatty acid binding protein (I-FABP in plasma [n = 72] and urine [n = 37]), citrulline (in plasma [n = 35]), and claudin-3 (in urine [n = 37]) in patients undergoing aortic or mitral valve surgery with or without coronary artery bypass grafting. Furthermore, the relationship between these markers and the surgery-induced cytokine response was explored by measuring serial plasma levels of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and IL-10 (n = 35). Finally, the relationship between markers of intestinal damage and GI-symptoms (abdominal pain, ileus, vomiting, diarrhea, time to first defecation) was assessed. RESULTS: Plasma and urinary I-FABP levels, and urinary claudin-3 levels peaked at the end of surgery, while citrulline levels were not influenced by surgery. ECC duration correlated with plasma I-FABP levels (r = 0.31, P = 0.007). Plasma levels of all measured cytokines increased during surgery, with peak levels observed either at the end of surgery or on the first postoperative day. While ECC duration correlated with IL-6 and IL-8 release (r = 0.43, P = 0.01 and r = 0.36, P = 0.04 respectively), there was no direct relationship between I-FABP and claudin-3 levels and cytokine concentrations. No patients developed significant GI or non-GI complications, and I-FABP and claudin-3 release appeared not to be related to postoperative GI symptoms, although the incidence of these symptoms may have limited a reliable assessment. CONCLUSIONS: Longer duration of ECC is associated with a more pronounced release of intestinal injury markers and inflammatory cytokines, but intestinal injury markers are not directly related to the observed increase in cytokine

Published
2017

8. Has the prognosis of septic patients improved over time?

Author

Habes, Q.L.M. and Pickkers, P.

Subjects
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Abstract

Contains fulltext : 134057.pdf (Publisher’s version ) (Open Access)

Published
2014

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