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2 results on '"H, Kohoka"'

1. Clinical value of cytokine antagonists in infectious complications

Author

H, Iwagaki, A, Hizuta, M, Uomoto, Y, Takeuchi, H, Kohoka, T, Okamoto, and N, Tanaka

Subjects
Adult, Inflammation, Male, Hydrocortisone, Macrophages, Receptors, Interleukin-1, Receptors, Interleukin-2, Bacterial Infections, Middle Aged, Intercellular Adhesion Molecule-1, Monocytes, Interleukin-10, Cytokines, Homeostasis, Humans, Female, Aged
Abstract

Plasma levels of antiinflammatory compounds (which counteract inflammation, cortisol, IL-1 receptor antagonist, IL-1ra; soluble IL-2 receptor, sIL-2r, soluble intercellular adhesion molecule-1, sICAM-1; interleukin-10, IL-10) were synchronously determined in a consecutive series of 25 patients with severe bacterial infections. Serum levels of cortisol, IL-1ra, sIL-2r, sICAM-1 and IL-10 were significantly higher in patients with infection compared with healthy volunteers. Bacterial infection results in the production of inflammatory and proinflammatory cytokines from macrophage/monocyte, which are thought to be involved in the pathogenesis of systemic inflammatory response syndrome (SIRS). We found that counter-inflammatory compounds can also be released during infectious insults. These results suggested that the biological activity of inflammatory mediators is inhibited by natural antiinflammatory compounds, and the body itself might down-regulate excessive inflammatory cascades through counteracting the inflammatory responses and restore homeostasis.

Published
1997

2. Clinical value of cytokine antagonists in infectious complications.

Author

Iwagaki H, Hizuta A, Uomoto M, Takeuchi Y, Kohoka H, Okamoto T, and Tanaka N

Subjects
Adult, Aged, Bacterial Infections immunology, Bacterial Infections pathology, Cytokines metabolism, Female, Homeostasis, Humans, Inflammation immunology, Inflammation metabolism, Inflammation pathology, Macrophages immunology, Macrophages metabolism, Macrophages pathology, Male, Middle Aged, Monocytes immunology, Monocytes metabolism, Monocytes pathology, Bacterial Infections blood, Cytokines antagonists & inhibitors, Hydrocortisone blood, Intercellular Adhesion Molecule-1 blood, Interleukin-10 blood, Receptors, Interleukin-1 blood, Receptors, Interleukin-2 blood
Abstract

Plasma levels of antiinflammatory compounds (which counteract inflammation, cortisol, IL-1 receptor antagonist, IL-1ra; soluble IL-2 receptor, sIL-2r, soluble intercellular adhesion molecule-1, sICAM-1; interleukin-10, IL-10) were synchronously determined in a consecutive series of 25 patients with severe bacterial infections. Serum levels of cortisol, IL-1ra, sIL-2r, sICAM-1 and IL-10 were significantly higher in patients with infection compared with healthy volunteers. Bacterial infection results in the production of inflammatory and proinflammatory cytokines from macrophage/monocyte, which are thought to be involved in the pathogenesis of systemic inflammatory response syndrome (SIRS). We found that counter-inflammatory compounds can also be released during infectious insults. These results suggested that the biological activity of inflammatory mediators is inhibited by natural antiinflammatory compounds, and the body itself might down-regulate excessive inflammatory cascades through counteracting the inflammatory responses and restore homeostasis.

Published
1997

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