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1,628 results on '"Guo, Zhigang"'

4. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a

Author

Wang Yao, Guo Zhigang, Yang Zhifeng, Deng Qingyan, Huang Yueming, and Chen Yanhong

Subjects
gastric cancer, linris, mature mir-34a, mir-34a precursor, apoptosis, Medicine
Abstract

The oncogenic role of long intergenic noncoding RNA for IGF2BP2 stability (LINRIS) has been reported in colorectal cancer. This research aimed to study its potential involvement in gastric cancer (GC). In this study, paired GC and non-tumor tissues were obtained from 64 GC patients, and the levels of LINRIS, mature microRNA-34a (miR-34a), and miR-34a precursor in these tissues were measured with RT-qPCR. Linear regression was used to analyze their correlations. The role of LINRIS overexpression and siRNA silencing in regulating the maturation of miR-34a was analyzed by RT-qPCR. Cell apoptosis was studied with flow cytometry. It was observed that LINRIS was overexpressed in GC and showed a negative correlation with mature miR-34a, but not miR-34a precursor. In GC cells, LINRIS siRNA silencing upregulated mature miR-34a level, but not miR-34a precursor level. LINRIS overexpression downregulated miR-34a level. Cell apoptosis analysis showed that LINRIS siRNA silencing and miR-34a overexpression promoted GC cell apoptosis and suppressed cell migration and invasion, while LINRIS overexpression suppressed cell apoptosis and enhanced cell migration and invasion. In addition, the effect of LINRIS overexpression was reversed by miR-34a overexpression. Therefore, LINRIS siRNA silencing in GC may promote cell apoptosis by promoting miR-34a maturation.

Published
2024
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5. Robust fractional-order fast terminal sliding mode control of aerial manipulator derived from a mutable inertia parameters model

Author

Zheng, Wenlei, Li, Zhan, Xiu, Bingkai, Zhao, Bingliang, and Guo, Zhigang

Subjects
Computer Science - Robotics
Abstract

The coupling disturbance between the manipulator and the unmanned aerial vehicle (UAV) deteriorates the control performance of system. To get high performance of the aerial manipulator, a robust fractional order fast terminal sliding mode control (FOFTSMC) strategy based on mutable inertia parameters is proposed in this paper. First, the dynamics of aerial manipulator with consideration of the coupling disturbance is derived by utilizing mutable inertia parameters. Then, based on the dynamic model, a robust FOFTSMC algorithm is designed to make the system fly steadily under coupling disturbance. Furthermore, stability analysis is conducted to prove the convergence of tracking errors. Finally, comparative simulation results are given to show the validity and superiority of the proposed scheme., Comment: This paper has been accepted by ICBDAI2022

Published
2022
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17. Comparison of clinical effects of coronary artery bypass grafting between left anterior small thoracotomy approach and lower-end sternal splitting approach

Author

Li Jinghui, Yang Yin, Muhetaer Xiaokaitijiang, Tang Yipeng, Wang Lianqun, Bai Yunpeng, Zhang Zhejun, Jiang Nan, Wang Qiang, Chen Qingliang, Xu Dong, Yang Dongyan, Guo Zhigang, and Zhao Feng

Subjects
Medicine (General), R5-920
Abstract

Objective To compare the clinical effects of coronary artery bypass grafting (CABG) between the left anterior small thoracotomy (LAST) and lower-end sternal splitting (LESS) approaches for coronary artery disease. Methods In total, 110 patients who underwent LAST from October 2015 to December 2020 in Tianjin Chest Hospital were selected as the observation group. Patients who underwent the LESS approach during the same period were analyzed. The propensity score was calculated by a logistic regression model, and nearest-neighbor matching was used for 1:1 matching. Results The length of hospital stay and ventilator support time were significantly shorter in the LAST than LESS group. The target vessels in the obtuse marginal branch and posterior left ventricular artery branch grafts were significantly more numerous in the LAST than LESS group, but those in the right coronary artery graft were significantly less numerous in the LAST group. Conclusions CABG using either the LAST or LESS approach is safe and effective, especially in low-risk patients. The LAST approach can achieve complete revascularization for multivessel lesions and has the advantages of less trauma and an aesthetic outcome. However, it requires a certain learning curve to master the surgical techniques and has specific surgical indications.

Published
2024
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19. Response of soil physicochemical properties and fruit quality to CL-PAM-Ks in apple orchards in dryland

Author

AN Xiaojuan, GUO Zhigang, CHEN Nana, JIA Yuanyuan, LI Yutao, ZOU Yali, and HU Liping

Subjects
super absorbent polymer, apple orchard, soil physicochemical properties, fruit quality, Agriculture (General), S1-972, Irrigation engineering. Reclamation of wasteland. Drainage, TC801-978
Abstract

【Background】 Drought is an important factor restricting China’s agricultural development. Tianshui City of Gansu Province is located in the inland, with a warm temperate semi-humid and semi-arid climate, thin soil layer, unfertile land and lack of irrigation conditions. Natural rainfall is an important source of agricultural irrigation water, but affected by geographical location and climatic conditions, the average annual rainfall is small and uneven. As a result, crops have low utilization efficiency of rainfall. Therefore, it is particularly important to improve crop water use efficiency in arid areas. CLP type super absorbent polymer is a kind of new polymer materials, water absorption and water retention ability is very strong, containing a large number of strong water absorption, high permeability can be induced by association with and through the base mesh structure, absorb hundreds of times to thousands of times more than its weight of water, for a variety of crops, fruit trees, vegetables and so on root directly provide plenty of water, to ensure that the crop growth environment, It has positive significance to improve the water use efficiency of orchard. 【Objective】 The purpose of this paper is to study the effect of CLP type super absorbent polymer on soil physical and chemical properties and fruit quality of apple orchard in dryland. 【Method】 This experiment used crosslinked polyacrylamide (acrylamide-potassium acrylate copolymer, English name is CL-PAM-K, abbreviated as CLP) super absorbent polymer. Set four treatments, respectively were: CK: no super absorbent polymer; T1:150 g/plant; T2:250 g/plant; T3:350 g/plant. Soil water content, soil nutrients, fruit appearance quality and nutritional quality were measured to comprehensively evaluate the effects of each treatment on soil physical and chemical properties and fruit quality. 【Result】 At the bud stage, T1 treatment decreased the soil electrical conductivity by 5.70%, 10.82% and 19.64%, in the 0-20 cm, 20-40 cm and 40-60 cm soil layers, respectively. At fruit ripening stage, T1 treatment increased the soil water content by 7.26% and 39.12% in the 20-40 cm and 40-60 cm soil layers, respectively, while decreasing the pH value by 3.43%, 1.38% and 0.23% in the 0-20 cm, 20-40 cm and 40-60 cm soil layers, respectively. The fruit peel puncture strength increased by 16%. The application of 250 g/plant increased the soil water content and available nitrogen in the 0~20 cm, 20-40 cm and 40-60 cm soil layers at the bud stage, as well as the available potassium in the 0-20 cm and 40-60 cm soil layers at both the bud stage and fruit ripening stage. The application of 350 g/plant increased the available phosphorus in the 0-20 cm, 20-40 cm and 40-60 cm soil layers at both the bud stage and fruit ripening stage. The application of 250 g/plant increased the soluble protein and total phenol content of apple fruits. 【Conclusion】 The application of 350 g/plant was the optimal amount of drought-resistant soil amendment to improve soil physical and chemical properties and enhance fruit quality in dryland apple orchards.

Published
2024
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26. Load-balanced Service Function Chaining in Edge Computing over FiWi Access Networks for Internet of Things

Author

Liu, Jing, Shou, Guochu, Wang, Qingtian, Liu, Yaqiong, Hu, Yihong, and Guo, Zhigang

Subjects
Computer Science - Networking and Internet Architecture, Computer Science - Distributed, Parallel, and Cluster Computing
Abstract

Service function chaining (SFC) is promising to implement flexible and scalable virtual network infrastructure for the Internet of Things (IoT). Edge computing is envisioned to be an effective solution to process huge amount of IoT application data. In order to uniformly provide services to IoT applications among the distributed edge computing nodes (ECNs), we present a unified SFC orchestration framework based on the coordination of SDN and NFV, which provides a synergic edge cloud platform by exploiting the connectivity of FiWi access networks. In addition, we study the VNF deployment problem under our synergic framework, and we formulate it as a mixed-integer nonlinear programming (MINLP) problem jointly considering the load balancing of networking and computing for chaining VNFs. We also propose two approximation optimal deployment algorithms named Greedy-Bisection Multi-Path (GBMP) and KSP MultiPath (KSMP) taking advantage of the multi-instance virtual network functions (VNFs) deployed in ECNs and the multipath capacity in FiWi access networks. Extensive simulations are conducted in two types of IoT application scenarios in the EC over FiWi access networks. The numerical results show that our proposed algorithms are superior to single path and ECMP based deployment algorithms in terms of load balancing, service acceptance ratio, and network utilization in both two typical scenarios.

Published
2020

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