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1. Contributing to Elimination of Cross-Border Malaria Through a Standardized Solution for Case Surveillance, Data Sharing, and Data Interpretation: Development of a Cross-Border Monitoring System

Author

Saldanha, Raphael, Mosnier, Émilie, Barcellos, Christovam, Carbunar, Aurel, Charron, Christophe, Desconnets, Jean-Christophe, Guarmit, Basma, Gomes, Margarete Do Socorro Mendonça, Mandon, Théophile, Mendes, Anapaula Martins, Peiter, Paulo César, Musset, Lise, Sanna, Alice, Van Gastel, Benoît, and Roux, Emmanuel

Subjects
Public aspects of medicine, RA1-1270
Abstract

BackgroundCross-border malaria is a significant obstacle to achieving malaria control and elimination worldwide. ObjectiveThis study aimed to build a cross-border surveillance system that can make comparable and qualified data available to all parties involved in malaria control between French Guiana and Brazil. MethodsData reconciliation rules based on expert knowledge were defined and applied to the heterogeneous data provided by the existing malaria surveillance systems of both countries. Visualization dashboards were designed to facilitate progressive data exploration, analysis, and interpretation. Dedicated advanced open source and robust software solutions were chosen to facilitate solution sharing and reuse. ResultsA database gathering the harmonized data on cross-border malaria epidemiology is updated monthly with new individual malaria cases from both countries. Online dashboards permit a progressive and user-friendly visualization of raw data and epidemiological indicators, in the form of time series, maps, and data quality indexes. The monitoring system was shown to be able to identify changes in time series that are related to control actions, as well as differentiated changes according to space and to population subgroups. ConclusionsThis cross-border monitoring tool could help produce new scientific evidence on cross-border malaria dynamics, implementing cross-border cooperation for malaria control and elimination, and can be quickly adapted to other cross-border contexts.

Published
2020
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6. Supplementary Figure Legends 1-5 from Thrombospondin-1 Triggers Cell Migration and Development of Advanced Prostate Tumors

Author

Firlej, Virginie, primary, Mathieu, Jacques R.R., primary, Gilbert, Cristèle, primary, Lemonnier, Loïc, primary, Nakhlé, Jessica, primary, Gallou-Kabani, Catherine, primary, Guarmit, Basma, primary, Morin, Aurélie, primary, Prevarskaya, Natalia, primary, Delongchamps, Nicolas Barry, primary, and Cabon, Florence, primary

Published
2023
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14. Invasive Fungal Infections in Persons Living with HIV in an Amazonian Context: French Guiana, 2009–2019

Author

Cachera, Laurène, primary, Adenis, Antoine, additional, Guarmit, Basma, additional, Rabier, Sébastien, additional, Couppié, Pierre, additional, Djossou, Felix, additional, Epelboin, Loïc, additional, Melzani, Alessia, additional, Abboud, Philippe, additional, Blanchet, Denis, additional, Demar, Magalie, additional, Alsibai, Kinan Drak, additional, and Nacher, Mathieu, additional

Published
2021
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15. What is AIDS in the Amazon and the Guianas in the 90-90-90 era?

Author

Nacher, Mathieu, primary, Adenis, Antoine, additional, Guarmit, Basma, additional, Lucarelli, Aude, additional, Blanchet, Denis, additional, Demar, Magalie, additional, Djossou, Felix, additional, Abboud, Philippe, additional, Epelboin, Loïc, additional, and Couppié, Pierre, additional

Published
2020
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18. Cross-border epidemiological data integration and harmonization – Application to malaria in the cross-border area between French Guiana and Brazil

Author

Roux, Emmanuel, Saldanha, Raphael, Barcellos, Christovam, Mandon, Théophile, Do Socorro Mendonca Gomes, Margarete, Mosnier, Emilie, Guarmit, Basma, Desconnets, Jean-Christophe, UMR 228 Espace-Dev, Espace pour le développement, Université de Guyane (UG)-Université des Antilles (UA)-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM), Institute of Scientific and Technological Communication and Information in Health / Instituto de Comunicação e Informação Científica e Tecnológica em Saúde [Rio de Janeiro] (ICICT), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), SVS-AP, Département des Centres Délocalisés de Prévention et de Soins, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université des Antilles (UA)-Université de Guyane (UG)-Université de Montpellier (UM)-Université de La Réunion (UR)-Avignon Université (AU)-Université de Perpignan Via Domitia (UPVD)-Institut de Recherche pour le Développement (IRD), LMI Sentinela, Réseau International des Instituts Pasteur (RIIP), Unité des Maladies Infectieuses et Tropicales (UMIT), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Roux, Emmanuel, Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM)-Université de Guyane (UG)-Université des Antilles (UA), and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)

Subjects
[INFO.INFO-OH] Computer Science [cs]/Other [cs.OH], [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB], [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [INFO.INFO-IR]Computer Science [cs]/Information Retrieval [cs.IR], [SHS.INFO]Humanities and Social Sciences/Library and information sciences, [INFO.INFO-OH]Computer Science [cs]/Other [cs.OH], [INFO.INFO-DB] Computer Science [cs]/Databases [cs.DB], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [INFO.INFO-IR] Computer Science [cs]/Information Retrieval [cs.IR], [SHS.INFO] Humanities and Social Sciences/Library and information sciences
Abstract

International audience; Context Ensure healthy lives and promote well-being for all at all ages Target: By 2030, end the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseases • Malaria: 216 million cases and 445 thousand deaths worldwide in 2016 (WHO, 2017) • Between 2000 and 2015, 58% and 37% decreases of the mortality and incidence rates, respectively • Socio-demographical and environmental contexts that vulnerabilize local populations • High mobility of pathogen-carrying populations • Patient follow-up difficulties (situations of illegality, auto-medication, ...) • Different strategies and means of surveillance, prevention and control of diseases between countries • Lack of international cooperation: Few regular exchange of comparable data and information between countries ⇒ Heterogeneous data types and formats, nomenclatures and concepts How to ensure cross-border epidemiological data interoperability on an ongoing basis? FTP server Computation and display application (R/Shiny) Harmonized DB Rebuilt DB Rebuilt DB Automated processing chain Integration and harmonization Indicator computation and visualization CHAR/CDPS Cayenne, FG Objectives and challenges • Integrate and harmonize automatically and regularly malaria cross-border epidemiological data • Disseminate indicators and data in an interpretable way for specialists, health actors and population In fine, this should conduct to • Provide a unified vision of the epidemiological cross-border situations • Participate to define concerted, targeted and effective control actions for disease elimination Cross-border malaria considered as a "Major obstacle for malaria elimination" [Wangdi et al., 2015] Paris France Study Region Ethical considerations • Exploitation and dissemination of anonymized data • Temporal and spatial aggregation of the data for public user profile • Authorization of the Commission Nationale de l'Informatique et des Libertés (CNIL) for personal data automatic processing and data transmission to a foreign country (ongoing request No. 2135463) • Multi-platform Extract Transform Load (ETL) tools (TALEND®) Harmonization rules based on expert knowledge in epidemiology and parasitology • Web services for data online publication • Web application (R-Shiny) for online data visualization CDPS ... Funding LMI Sentinela GAPAM Sentinela GCE18-Investment ID OPP1171795 Wangdi K. et al. Cross-border malaria: A major obstacle for malaria elimination. Adv. Parasitol. 2015, 89, 79-107 Barcellos C. et al. An observatory to gather and disseminate information on the health-related effects of environmental and climate change. Pan American Journal of Public Health. 2016. 40(3): 167-73 Roux E. et al. Un "site sentinelle" à la frontière franco-brésilienne pour comprendre et suivre les relations entre climat et santé. In Proceedings of the ENVIBRAS (Environnement et géomatique-approches comparées France Brésil) conference. Rennes; 2014:1-8

Published
2018

19. Contributing to Elimination of Cross-Border Malaria Through a Standardized Solution for Case Surveillance, Data Sharing, and Data Interpretation: Development of a Cross-Border Monitoring System (Preprint)

Author

Saldanha, Raphael, primary, Mosnier, Émilie, additional, Barcellos, Christovam, additional, Carbunar, Aurel, additional, Charron, Christophe, additional, Desconnets, Jean-Christophe, additional, Guarmit, Basma, additional, Gomes, Margarete Do Socorro Mendonça, additional, Mandon, Théophile, additional, Mendes, Anapaula Martins, additional, Peiter, Paulo César, additional, Musset, Lise, additional, Sanna, Alice, additional, Van Gastel, Benoît, additional, and Roux, Emmanuel, additional

Published
2019
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20. Cryptosporidiosis Outbreak in Immunocompetent Children from a Remote Area of French Guiana

Author

Mosnier, Emilie, Martin, Noémie, Razakandrainibe, Romy, Dalle, Frédéric, Roux, Guillaume, Buteux, Arnaud, Favennec, Loïc, Brousse, Paul, Guarmit, Basma, Blanchet, Denis, Epelboin, Loïc, Girouin, Camille, Martin, Elise, Djossou, Félix, Nacher, Mathieu, Demar, Magalie Pierre, Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Laboratoire de parasitologie mycologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie, Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Université des Antilles (UA), Département des Centres Délocalisés de Prévention et de Soins, Agence Régionale de la Santé, Cayenne, Guyane française (ARS), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine [Cayenne, Guyane] (COREVIH)

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; In September 2014, an increase in the number of Cryptosporidium spp. gastrointestinal tract infections was reported over a 6-month period among children living in a remote area along the Maroni River in French Guiana. Children presented gastroenteritis symptoms with Cryptosporidium-positive stools. Questionnaires were administered and stool examinations were controlled 3 months after the onset of symptoms. Data collection included demographics, food consumption, river behavior, symptoms, and outcome. Stool specimens were tested using microscopy and polymerase chain reaction. Samples from the water systems were examined for turbidity and culture for bacteria. Data from the reference laboratory were analyzed to calculate the median cryptosporidiosis incidence among immunocompetent patients from 2008 to 2015. Data on gastroenteritis cases reported by the Delocalized Center for Prevention and Care in the area were also collected. We report a cluster of 14 cases. All cases were children, aged between 4.5 and 38 months. Seven reported moderate to severe dehydration and required hospitalization. Speciation and microbiological typing revealed the cluster strain was Cryptosporidium hominis subtype IbA10G2 but C. hominis IbA9G2 and IbA15G1 strains were also identified. The median incidence in French Guiana was 5.8 cases per year before the outbreak. The first cases of the cluster appeared in the dry season. We describe the clinical features, epidemiology, and state of current investigations for the largest documented outbreak of cryptosporidiosis in French Guiana.

Published
2018
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21. Spatial dynamics and epidemiology for AIDS in remote areas in French Guiana

Author

Mosnier, Emilie, primary, Epelboin, Loïc, additional, Guiraud, Noé, additional, Huber, Florence, additional, Adriouch, Leila, additional, Guarmit, Basma, additional, Brousse, Paul, additional, Terraz, Anne, additional, Boser, Anna, additional, Gaillet, Mélanie, additional, Djossou, Félix, additional, Adenis, Antoine, additional, and Nacher, Mathieu, additional

Published
2018
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22. Spacial dynamics and social risk factor for AIDS in isolated area in French Guiana

Author

Mosnier, Emilie, Guiraud, Noé, Epelboin, Loïc, Huber, Florence, Adriouch, Leila, Guarmit, Basma, Djossou, Félix, Brousse, Paul, Terraz, Anne, Ville, Muriel, Adenis, Antoine, Nacher, Mathieu, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Département des Centres Délocalisés de Prévention et de Soins, Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Groupement de Recherche en Économie Quantitative d'Aix-Marseille (GREQAM), École Centrale de Marseille (ECM)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Hôpital de Jour [Cayenne], Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, and École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, parasitic diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; French Guiana, a French overseas department in South America, has been classified epidemic for HIV. The dynamics of the spread of the AIDS epidemic ranges according to the characteristics of each geographical region in different population groups. Isolated area in French Guiana have a vast diversity of population including maroon population, amerindians and migrants in particulary from Brazil, Surinam and Guyana. Isolated area in French Guiana is defined by all rural areas compared to urban area: Cayenne, Kourou and Saint Laurent du Maroni (Map 1). The aim of this study was to evaluate spacial and temporal trend of the AIDS epidemic among type of population on isolated area of French Guiana.

Published
2016

23. Les périphéries de l’épidémie de VIH en Guyane : particularités des zones isolées VIH-06

Author

Mosnier, Emilie, Epelboin, Loïc, Guiraud, Noé, Renaud, M., Guarmit, Basma, Auz, M., Huber, Florence, Carrera, C., Ville, M., Djossou, Félix, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyane Française], Université de Guyane (UG), and Matillon, Mirlène

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

25. Diagnostic et prise en charge des PVVIH en zones isolées et frontalières en Guyane

Author

Mosnier, Emilie, Guiraud, Noé, Epelboin, Loïc, Huber, Florence, Adriouch, Leila, Guarmit, Basma, Djossou, Félix, Douine, Maylis, Brousse, Paul, Terraz, Anne, Ville, Muriel, Adenis, Antoine, Nacher, Mathieu, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Département des Centres Délocalisés de Prévention et de Soins, Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Groupement de Recherche en Économie Quantitative d'Aix-Marseille (GREQAM), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], École Centrale de Marseille (ECM)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424

Subjects
isolement géographique, populations négligées, populations clés, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, santé publique, VIH, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, populations autochtones, migrants
Abstract

National audience; Bien que la prise en charge de personnes vivant avec le VIH (PVVIH) s’améliore globalement en Guyane, les disparités entre les régions et les différentes populations-clés sont importantes. Cet article a pour objectif de décrire les caractéristiques épidémiologiques, spatiales et cliniques des PVVIH suivies en zones isolées en les comparant avec celles suivies sur le littoral, dans les centres hospitaliers, en Guyane Française.Les données présentées reposent sur les données de suivi clinique réalisé au cours des missions délocalisées d’infectiologie au sein des Centres Délocalisés de Prévention et de Soins (CDPS) de Guyane. Ces données ont été analysées en relation avec les données INSEE issue du dernier recensement des communes de Guyane en 2012 et comparées aux données de suivi des PVVIH dans les différents centres hospitaliers de Guyane issues du logiciel Nadis®.L’évolution du taux annuel de découvertes de séropositivité VIH montre une arrivée plus tardive en zones isolées que sur le littoral de cette infection. L’épidémie apparait ces dernières années comme particulièrement active notamment chez les patients d’origine Brésilienne. L’âge médian des PVVIH en CDPS est de 43,8 ans, le sex ratio homme/femme est de 0,98. Prés de 37% des PVVIH sont dépistées au stade tardif (< 200 CD4/mm3). Le pourcentage de succès virologiques après 6 mois de traitement est de 80% par rapport à 88% sur le littoral.L’histoplasmose est la première cause d’infection opportuniste retrouvée. Les infections tropicales et notamment le paludisme (16%) sont fréquentes. La répartition spatiale des patients suivis montre une absence de PPVIH identifiées en amont des villes de Maripasoula et Saint Georges de l’Oyapock. Ces caractéristiques géographiques régionales rappellent l’importance de prendre en charge les PVVIH en zones isolées, particulièrement aux frontières, qui constituent des zones de passage, de repli, de prise de risques mais aussi de carence en offre de dépistage et de soins.Ainsi, en zones isolées en Guyane Française, les efforts doivent être poursuivis afin d’enrayer et de contrôler la diffusion de l’épidémie de VIH sur ces zones devenues stratégiques en terme de santé publique.

Published
2015

26. Spatial dynamics and epidemiology for AIDS in remote areas in French Guiana.

Author

Mosnier, Emilie, Epelboin, Loïc, Guiraud, Noé, Huber, Florence, Adriouch, Leila, Guarmit, Basma, Brousse, Paul, Terraz, Anne, Boser, Anna, Gaillet, Mélanie, Djossou, Félix, Adenis, Antoine, and Nacher, Mathieu

Subjects
AIDS prevention, AIDS epidemiology, ANTIRETROVIRAL agents, COMMUNITY health services, EPIDEMICS, MEDICAL records, PRIMARY health care, RURAL conditions, RURAL health, SEX distribution, URBAN health, URBAN hospitals, VIROLOGY, HIV seroconversion
Abstract

Although AIDS care is generally improving in French Guiana, disparities among regions and certain key populations remain significant. The purpose of this study was to describe the spatial and clinical characteristics of people living with HIV (PLHIV) in remote areas in comparison to those followed in hospitals on the urban coast of French Guiana. The data presented were obtained from outpatient on primary care centers located in rural regions away from the urban coast. Data were compared with that from medical records of PLHIV treated in French Guiana's urban care. The evolution of the annual rate of discovery of HIV seropositivity indicates a lag in remote areas as compared to urban and coastal areas. In recent years, the epidemic appeared as particularly active in rural areas among Brazilian patients. The median age of PLHIV in remote areas was 43.8 years, the sex ratio (M/F) was 0.93. Nearly 37% of PLHIV were discovered with advanced disease (<200 CD4/mm3). The percentage of virological success after six months of HAART was 80% and 88% in remote areas and urban area, respectively. Efforts must be made to control and halt the spread of the HIV epidemic, as these remote sites represent strategic points. [ABSTRACT FROM AUTHOR]

Published
2019
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27. TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity

Author

Gkika, Dimitra, primary, Lemonnier, Loic, additional, Shapovalov, George, additional, Gordienko, Dmitri, additional, Poux, Céline, additional, Bernardini, Michela, additional, Bokhobza, Alexandre, additional, Bidaux, Gabriel, additional, Degerny, Cindy, additional, Verreman, Kathye, additional, Guarmit, Basma, additional, Benahmed, Mohamed, additional, de Launoit, Yvan, additional, Bindels, Rene J.M., additional, Pla, Alessandra Fiorio, additional, and Prevarskaya, Natalia, additional

Published
2015
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30. Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence.

Author

Morin, Aurélie, Fritsch, Lauriane, Mathieu, Jacques R. R., Gilbert, Cristèle, Guarmit, Basma, Firlej, Virginie, Gallou-Kabani, Catherine, Vieillefond, Annick, Delongchamps, Nicolas Barry, and Cabon, Florence

Subjects
PROSTATE cancer, CANCER relapse, PROSTATECTOMY complications, ANDROGENS, BIOMARKERS
Abstract

Markers of prostate tumor recurrence after radical prostatectomy are lacking and highly demanded. The androgen receptor (AR) is a nuclear receptor that plays a pivotal role in normal and cancerous prostate tissue. AR interacts with a number of proteins modulating its stability, localization, and activity. To test the hypothesis that an increased expression of AR partners might foster tumor development, we immunopurified AR partners in human tumors xenografted into mice. One of the identified AR partners was the multifunctional enzyme carbamoyl-phosphate synthetase II, aspartate transcarbamylase, and dihydroorotase (CAD), which catalyzes the 3 initial steps of pyrimidine biosynthesis. We combined experiments in C4-2, LNCaP, 22RV1, and PC3 human prostate cell lines and analysis of frozen radical prostatectomy samples to study the CAD-AR interaction. We show here that in prostate tumor cells, CAD fosters AR translocation into the nucleus and stimulates its transcriptional activity. Notably, in radical prostatectomy specimens, CAD expression was not correlated with proliferation markers, but a higher CAD mRNA level was associated with local tumor extension (P=0.049) and cancer relapse (P=0.017). These results demonstrate an unsuspected function for a key metabolic enzyme and identify CAD as a potential predictive marker of cancer relapse. [ABSTRACT FROM AUTHOR]

Published
2012
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31. TRP channel--associated factors are a novel protein family that regulates TRPM8 trafficking and activity.

Author

Gkika, Dimitra, Lemonnier, Loic, Shapovalov, George, Gordienko, Dmitri, Poux, Céline, Bernardini, Michela, Bokhobza, Alexandre, Bidaux, Gabriel, Degerny, Cindy, Verreman, Kathye, Guarmit, Basma, Benahmed, Mohamed, de Launoit, Yvan, Bindels, Rene J. M., Fiorio Pla, Alessandra, and Prevarskaya, Natalia

Subjects
*PROTEIN research, *TRP channels, *CELLULAR signal transduction, *CATIONS, *CYTOLOGICAL research
Abstract

TRPM8 is a cold sensor that is highly expressed in the prostate as well as in other non-temperature-sensing organs, and is regulated by downstream receptor-activated signaling pathways. However, little is known about the intracellular proteins necessary for channel function. Here, we identify two previously unknown proteins, which we have named "TRP channel-associated factors" (TCAFs), as new TRPM8 partner proteins, and we demonstrate that they are necessary for channel function. TCAF1 and TCAF2 both bind to the TRPM8 channel and promote its trafficking to the cell surface. However, they exert opposing effects on TRPM8 gating properties. Functional interaction of TCAF1/TRPM8 also leads to a reduction in both the speed and directionality of migration of prostate cancer cells, which is consistent with an observed loss of expression of TCAF1 in metastatic human specimens, whereas TCAF2 promotes migration. The identification of TCAFs introduces a novel mechanism for modulation of TRPM8 channel activity. [ABSTRACT FROM AUTHOR]

Published
2015
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32. Cryptosporidiosis Outbreak in Immunocompetent Children from a Remote Area of French Guiana.

Author

Mosnier E, Martin N, Razakandrainibe R, Dalle F, Roux G, Buteux A, Favennec L, Brousse P, Guarmit B, Blanchet D, Epelboin L, Girouin C, Martin E, Djossou F, Nacher M, and Demar M

Subjects
Child, Preschool, Cryptosporidiosis parasitology, Cryptosporidium genetics, Demography, Feces parasitology, Female, French Guiana epidemiology, Gastroenteritis parasitology, Gastrointestinal Tract parasitology, Humans, Immunocompetence, Infant, Male, Polymerase Chain Reaction, Rivers, Rural Population, Surveys and Questionnaires, Cryptosporidiosis epidemiology, Cryptosporidium isolation & purification, Disease Outbreaks, Gastroenteritis epidemiology
Abstract

In September 2014, an increase in the number of Cryptosporidium spp. gastrointestinal tract infections was reported over a 6-month period among children living in a remote area along the Maroni River in French Guiana. Children presented gastroenteritis symptoms with Cryptosporidium -positive stools. Questionnaires were administered and stool examinations were controlled 3 months after the onset of symptoms. Data collection included demographics, food consumption, river behavior, symptoms, and outcome. Stool specimens were tested using microscopy and polymerase chain reaction. Samples from the water systems were examined for turbidity and culture for bacteria. Data from the reference laboratory were analyzed to calculate the median cryptosporidiosis incidence among immunocompetent patients from 2008 to 2015. Data on gastroenteritis cases reported by the Delocalized Center for Prevention and Care in the area were also collected. We report a cluster of 14 cases. All cases were children, aged between 4.5 and 38 months. Seven reported moderate to severe dehydration and required hospitalization. Speciation and microbiological typing revealed the cluster strain was Cryptosporidium hominis subtype IbA10G2 but C. hominis IbA9G2 and IbA15G1 strains were also identified. The median incidence in French Guiana was 5.8 cases per year before the outbreak. The first cases of the cluster appeared in the dry season. We describe the clinical features, epidemiology, and state of current investigations for the largest documented outbreak of cryptosporidiosis in French Guiana.

Published
2018
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