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38 results on '"Greenberg, Jacob W."'

12. Increased prostate volume on transrectal ultrasound and magnetic resonance imaging are potential risk factors for acute urinary retention following transperineal prostate biopsy.

Author

Sandberg, Maxwell, primary, Whitman, Wyatt, additional, Hingu, Janmejay, additional, Thakker, Parth, additional, Rong, Anita, additional, Bercu, Caleb, additional, Greenberg, Jacob W., additional, Davis, Ronald, additional, Hemal, Ashok, additional, and Tsivian, Matvey, additional

Published
2023
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18. Five-Year Prospective Observational Study of African-American Men on Active Surveillance for Prostate Cancer Demonstrates Race Is Not Predictive of Oncologic Outcomes.

Author

Pincus, Joshua, Greenberg, Jacob W, Natale, Caleb, Koller, Christopher R, Miller, Stephanie, Silberstein, Jonathan L, and Krane, L Spencer

Subjects
DISEASE progression, EVALUATION of medical care, SCIENTIFIC observation, MULTIVARIATE analysis, RACE, CANCER relapse, RISK assessment, DESCRIPTIVE statistics, KAPLAN-Meier estimator, PROGRESSION-free survival, HEALTH equity, AFRICAN Americans, PROSTATE tumors, LONGITUDINAL method, TUMOR grading, OVERALL survival, PROBABILITY theory
Abstract

Introduction: This study aimed to evaluate if race impacted outcomes or risk of disease progression in men on active surveillance (AS) for prostate cancer. We present the results from our majority African-American cohort of men in an equal access setting over a 5-year follow-up period. Patients and Methods: All patients who elected AS for prostate cancer at the Southeast Louisiana Veterans Health Care System are entered into a prospectively managed observational database. Patients were divided into groups based on self-reported race. Grade group progression was defined as pathologic upgrading above International Society of Urological Pathology Grade Group 1 disease on subsequent biopsies following diagnostic biopsy. All tests were 2 sided using a significance of.05. Results: A total of 228 men met inclusion criteria in the study, including 154 non-Hispanic African American and 74 non-Hispanic Caucasian American men, with a median follow-up of 5 years from the initiation of AS. Race was not predictive of Gleason grade progression, AS discontinuation, or biochemical recurrence on Cox multivariate analysis (HR = 1.01, 0.94, 0.85, P =.96,.79,.81, respectively). On Kaplan-Meier analysis at 5 years, African-American progression-free, AS discontinuation free, and overall survival probability was comparable to their Caucasian American counterparts (P >.05 for all). Conclusions: Active surveillance is a safe treatment option for low and very low risk prostate cancer, regardless of race. African-American and Caucasian-American men did not have any significant difference in Gleason grade group progression in our cohort with 5-year follow-up. Men of African American heritage have been historically excluded from active surveillance (AS), considered the most conservative treatment option for those diagnosed with prostate cancer. This article evaluates whether race is predictive of AS in an equal access to care setting, with a 5-year follow-up. Race was not found to be a predictor and AS can safely be offered to AA men diagnosed with low risk prostrate cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Assessing the safety of bladder-preserving therapy as an alternative to surgical intervention in elderly patients with muscle invasive bladder cancer

Author

Koller, Christopher R., Greenberg, Jacob W., Natale, Caleb, and Krane, L. Spencer

Abstract

Background: There is interest in using bladder-preserving therapy as an alternative definitive therapy for muscle invasive bladder cancer in certain high-risk groups such as the elderly.Objective: To determine if bladder-preserving therapy represents a safer alternative to surgical intervention in elderly patients with muscle invasive bladder cancer.Methods: We surveyed the Surveillance, Epidemiology and End Results database (SEER) for cases of non-metastasized malignant bladder cancer in patients aged 80+. Survival outcomes with radical cystectomy (RC) with or without chemotherapy were compared to those after chemotherapy and radiation without cystectomy. We performed log-rank tests and Kaplan-Meier and cox regression and hazard analyses before and after propensity score matching.Results: A total of 2995 patients were identified, with 49.98% treated with RC only, 8.65% treated with RC/chemotherapy, and 41.37% treated with chemotherapy and radiation without RC. Median overall survival for the RC only, RC/chemotherapy and chemotherapy/radiation groups were 31.4, 44.1, and 24.6 months, respectively. On multivariate analysis, hazard ratios (reference: RC/chemotherapy group) were RC Only (HR = 1.408 (95% CI 1.188–1.669), p< 0.0001) and chemotherapy/radiation (HR = 1.650 (95% CI 1.390–1.959), p< 0.0001). After matching the chemotherapy/radiation and RC/chemotherapy groups, the former continued to show survival hazard (HR = 1.744 (95% CI 1.414–2.155), p< 0.0001).Conclusions: Octogenarians should be offered definitive local therapy for their localized bladder cancer including RC and chemotherapy. Bladder-sparing alternatives should be reserved for patients unfit for surgery.

Published
2024
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