Search

Your search keyword '"Grégoire, Marc"' showing total 275 results
Start Over Author "Grégoire, Marc" Publication Year Range Last 50 years
275 results on '"Grégoire, Marc"'

4. Algorithms

Author

Van Weert, Peter, Gregoire, Marc, Van Weert, Peter, and Gregoire, Marc

Published
2019
Full Text
View/download PDF

8. Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus

Author

Delaunay, Tiphaine, Achard, Carole, Boisgerault, Nicolas, Grard, Marion, Petithomme, Tacien, Chatelain, Camille, Dutoit, Soizic, Blanquart, Christophe, Royer, Pierre-Joseph, Minvielle, Stéphane, Quetel, Lisa, Meiller, Clément, Jean, Didier, Fradin, Delphine, Bennouna, Jaafar, Magnan, Antoine, Cellerin, Laurent, Tangy, Frédéric, Grégoire, Marc, and Fonteneau, Jean-François

Published
2020
Full Text
View/download PDF

11. Stream I/O

Author

Van Weert, Peter, Gregoire, Marc, Van Weert, Peter, and Gregoire, Marc

Published
2016
Full Text
View/download PDF

15. Algorithms

Author

Van Weert, Peter, Gregoire, Marc, Van Weert, Peter, and Gregoire, Marc

Published
2016
Full Text
View/download PDF

23. Brain-derived neurotrophic factor, a new soluble biomarker for malignant pleural mesothelioma involved in angiogenesis

Author

Smeele, Patrick, d’Almeida, Sènan Mickaël, Meiller, Clément, Chéné, Anne-Laure, Liddell, Charly, Cellerin, Laurent, Montagne, François, Deshayes, Sophie, Benziane, Sarah, Copin, Marie-Christine, Hofman, Paul, Le Pimpec-Barthes, Françoise, Porte, Henri, Scherpereel, Arnaud, Grégoire, Marc, Jean, Didier, and Blanquart, Christophe

Published
2018
Full Text
View/download PDF

29. KRAS signaling in malignant pleural mesothelioma

Author

Marazioti, Antonia, primary, Krontira, Anthi C, additional, Behrend, Sabine J, additional, Giotopoulou, Georgia A, additional, Ntaliarda, Giannoula, additional, Blanquart, Christophe, additional, Bayram, Hasan, additional, Iliopoulou, Marianthi, additional, Vreka, Malamati, additional, Trassl, Lilith, additional, Pepe, Mario A A, additional, Hackl, Caroline M, additional, Klotz, Laura V, additional, Weiss, Stefanie A I, additional, Koch, Ina, additional, Lindner, Michael, additional, Hatz, Rudolph A, additional, Behr, Juergen, additional, Wagner, Darcy E, additional, Papadaki, Helen, additional, Antimisiaris, Sophia G, additional, Jean, Didier, additional, Deshayes, Sophie, additional, Grégoire, Marc, additional, Kayalar, Özgecan, additional, Mortazavi, Deniz, additional, Dilege, Şükrü, additional, Tanju, Serhan, additional, Erus, Suat, additional, Yavuz, Ömer, additional, Bulutay, Pınar, additional, Fırat, Pınar, additional, Psallidas, Ioannis, additional, Spella, Magda, additional, Giopanou, Ioanna, additional, Lilis, Ioannis, additional, Lamort, Anne‐Sophie, additional, and Stathopoulos, Georgios T, additional

Published
2021
Full Text
View/download PDF

32. High oncolytic activity of a double deleted Vaccinia Virus Copenhagen strain against malignant pleural mesothelioma

Author

Delaunay, Tiphaine, Nader, Joëlle, Grard, Marion, Farine, Isabelle, Hedwig, Vera, Foloppe, Johann, Blondy, Thibaut, Violland, Mathilde, Pouliquen, Daniel, Grégoire, Marc, Boisgerault, Nicolas, Erbs, Philippe, Fonteneau, Jean-François, Immunogenic Cell Death and Mesothelioma Therapy (CRCINA-ÉQUIPE 4), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Transgene SA [Illkirch], Senescence Escape and Soluble Markers of Cancer Progression (CRCINA-ÉQUIPE 12), and Bernardo, Elizabeth

Subjects
[SDV.CAN] Life Sciences [q-bio]/Cancer, Oncolytic immunotherapy, thymidine kinase, [SDV.CAN]Life Sciences [q-bio]/Cancer, ribonucleotide reductase, vaccinia virus, Pleural mesothelioma
Abstract

International audience; Malignant pleural mesothelioma (MPM) is a cancer of the pleura that lacks efficient treatment. Oncolytic immunotherapy using oncolytic vaccinia virus (VV) may represent an alternative therapeutic approach for the treatment of this malignancy. Here we studied the oncolytic activity of VVTK-RR-/GFP against MPM. This virus is a VV from the Copenhagen strain that is deleted of two genes encoding the thymidine kinase (J2R) and the ribonucleotide reductase (I4L) and that express the green fluorescent protein (GFP). First we show in vitro that VVTK-RR-/GFP efficiently infects and kills the twenty two human MPM cell lines used in this study. We also show that the virus replicates in all eight tested MPM cell lines, however with approximately a 10-fold differences in the amplification level from one cell line to another. Then we studied the therapeutic efficiency of VVTK-RR-/GFP in NOD Scid mice that bear peritoneal human MPM tumors. One intraperitoneal infection of VVTK-RR-/GFP reduces the tumor burden and significantly increases mice survival compared to untreated animals. Thus VVTK-RR- may be a promising OV for the oncolytic immunotherapy of MPM.

Published
2020

33. Impact of chemotherapy on lung cancer cells and their microenvironment, evaluated in tridimensional multicellular tumor spheroids

Author

Hulo, Pauline, Deshayes, Sophie, Dehame, Virginie, Grégoire, Marc, Bennouna, Jaafar, Blanquart, Christophe, Immunogenic Cell Death and Mesothelioma Therapy (CRCINA-ÉQUIPE 4), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), and Bernardo, Elizabeth

Subjects
[SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.CAN]Life Sciences [q-bio]/Cancer, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

35. KRASsignalling in malignant pleural mesothelioma

Author

Marazioti, Antonia, primary, Blanquart, Christophe, additional, Krontira, Anthi C., additional, Pepe, Mario A. A., additional, Hackl, Caroline M., additional, Iliopoulou, Marianthi, additional, Lamort, Anne-Sophie, additional, Koch, Ina, additional, Lindner, Michael, additional, Hatz, Rudolph A., additional, Wagner, Darcy E., additional, Papadaki, Helen, additional, Antimisiaris, Sophia G., additional, Psallidas, Ioannis, additional, Spella, Magda, additional, Giopanou, Ioanna, additional, Lilis, Ioannis, additional, Grégoire, Marc, additional, and Stathopoulos, Georgios T., additional

Published
2020
Full Text
View/download PDF

38. Involvement of the M-CSF/IL-34/CSF-1R pathway in malignant pleural mesothelioma

Author

Blondy, Thibaut, primary, d'Almeida, Sènan Mickael, additional, Briolay, Tina, additional, Tabiasco, Julie, additional, Meiller, Clément, additional, Chéné, Anne-Laure, additional, Cellerin, Laurent, additional, Deshayes, Sophie, additional, Delneste, Yves, additional, Fonteneau, Jean-François, additional, Boisgerault, Nicolas, additional, Bennouna, Jaafar, additional, Grégoire, Marc, additional, Jean, Didier, additional, and Blanquart, Christophe, additional

Published
2020
Full Text
View/download PDF

39. S100A4 Is a Biomarker of Tumorigenesis, EMT, Invasion, and Colonization of Host Organs in Experimental Malignant Mesothelioma

Author

Nader, Joëlle S., primary, Guillon, Jordan, additional, Petit, Coralie, additional, Boissard, Alice, additional, Franconi, Florence, additional, Blandin, Stéphanie, additional, Lambot, Sylvia, additional, Grégoire, Marc, additional, Verrièle, Véronique, additional, Nawrocki-Raby, Béatrice, additional, Birembaut, Philippe, additional, Coqueret, Olivier, additional, Guette, Catherine, additional, and Pouliquen, Daniel L., additional

Published
2020
Full Text
View/download PDF

40. Cisplatin unleashes Toll-like receptor 3-mediated apoptosis through the downregulation of c-FLIP in malignant mesothelioma

Author

Vanbervliet-Defrance, Béatrice, primary, Delaunay, Tiphaine, additional, Daunizeau, Thomas, additional, Kepenekian, Vahan, additional, Glehen, Olivier, additional, Weber, Kathrin, additional, Estornes, Yann, additional, Ziverec, Audrey, additional, Djemal, Leila, additional, Delphin, Marion, additional, Lantuéjoul, Sylvie, additional, Passot, Guillaume, additional, Grégoire, Marc, additional, Micheau, Olivier, additional, Blanquart, Christophe, additional, Renno, Toufic, additional, Fonteneau, Jean-François, additional, Lebecque, Serge, additional, and Mahtouk, Karène, additional

Published
2020
Full Text
View/download PDF

48. Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma

Author

Nader, Joëlle, Abadie, Jérôme, Deshayes, Sophie, Boissard, Alice, Blandin, Stéphanie, Blanquart, Christophe, Boisgerault, Nicolas, Coqueret, Olivier, Guette, Catherine, Grégoire, Marc, Pouliquen, Daniel, Immunogenic Cell Death and Mesothelioma Therapy (CRCINA-ÉQUIPE 4), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Senescence Escape and Soluble Markers of Cancer Progression (CRCINA-ÉQUIPE 12), ONIRIS [Nantes], Université de Nantes (UN), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Plateforme MicroPicell [Nantes], The research leading to these results has received funding from the National Health and Medical Research Institute (Inserm), the 'Ligue contre le Cancer' (Ligue Nationale and the Ligue inter-régionale du Grand Ouest, Comités 16, 44 et 72), the 'Fondation pour la Recherche Médicale' (FRM), the 'Région Pays de la Loire', the Institut de Recherche en Santé Respiratoire (IRSR) des Pays de la Loire, and the ARSMESO44 association., Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), and Bernardo, Elizabeth

Subjects
immune cells, [SDV.CAN] Life Sciences [q-bio]/Cancer, rat model, invasiveness, stroma, [SDV.CAN]Life Sciences [q-bio]/Cancer, sarcomatoid mesothelioma, Research Paper
Abstract

International audience; Sarcomatoid mesothelioma (SM) is a devastating cancer associated with one of the poorest outcome. Therefore, representative preclinical models reproducing different tumor microenvironments (TME) observed in patients would open up new prospects for the identification of markers and evaluation of innovative therapies. Histological analyses of four original models of rat SM revealed their increasing infiltrative and metastatic potential were associated with differences in Ki67 index, blood-vessel density, and T-lymphocyte and macrophage infiltration. In comparison with the noninvasive tumor M5-T2, proteomic analysis demonstrated the three invasive tumors F4-T2, F5-T1 and M5-T1 shared in common a very significant increase in the abundance of the multifunctional proteins galectin-3, prohibitin and annexin A5, and a decrease in proteins involved in cell adhesion, tumor suppression, or epithelial differentiation. The increased metastatic potential of the F5-T1 tumor, relative to F4-T2, was associated with an increased macrophage vs T-cell infiltrate, changes in the levels of expression of a panel of cytokine genes, an increased content of proteins involved in chromatin organization, ribosome structure, splicing, or presenting anti-adhesive properties, and a decreased content of proteins involved in protection against oxidative stress, normoxia and intracellular trafficking. The most invasive tumor, M5-T1, was characterized by a pattern of specific phenotypic and molecular features affecting the presentation of MHC class I-mediated antigens and immune cell infiltration, or involved in the reorganization of the cytoskeleton and composition of the extracellular matrix. These four preclinical models and data represent a new resource available to the cancer research community to catalyze further investigations on invasiveness.

Published
2018

49. Additional file 5: of Brain-derived neurotrophic factor, a new soluble biomarker for malignant pleural mesothelioma involved in angiogenesis

Author

Smeele, Patrick, Sènan D’Almeida, Meiller, Clément, Anne-Laure Chéné, Liddell, Charly, Cellerin, Laurent, Montagne, François, Deshayes, Sophie, Benziane, Sarah, Marie-Christine Copin, Hofman, Paul, Pimpec-Barthes, Françoise Le, Porte, Henri, Scherpereel, Arnaud, Grégoire, Marc, Jean, Didier, and Blanquart, Christophe

Abstract

Table S3. Signification of abbreviations used in Fig. 1e. (DOCX 15 kb)

Published
2018
Full Text
View/download PDF

50. Additional file 6: of Brain-derived neurotrophic factor, a new soluble biomarker for malignant pleural mesothelioma involved in angiogenesis

Author

Smeele, Patrick, Sènan D’Almeida, Meiller, Clément, Anne-Laure Chéné, Liddell, Charly, Cellerin, Laurent, Montagne, François, Deshayes, Sophie, Benziane, Sarah, Marie-Christine Copin, Hofman, Paul, Pimpec-Barthes, Françoise Le, Porte, Henri, Scherpereel, Arnaud, Grégoire, Marc, Jean, Didier, and Blanquart, Christophe

Abstract

Figure S3. BDNF expression in MPM, neoplasia and primary mesothelial cells. A) mRNA expression of BDNF in MPM neoplastic cells and primary mesothelial cells (MC). Black squares: lung ADCA cell lines; open square: pancreatic cancer cell line; black triangle: mesothelial cells from pleura; open circle: mesothelial cells from peritoneum. Red bars correspond to median. *p

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results