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255 results on '"Gouw, Annette S. H."'

3. Severe acute liver disease in adults: Contemporary role of histopathology

Author

Clouston, Andrew D, primary, Gouw, Annette S H, additional, Tiniakos, Dina, additional, Bedossa, Pierre, additional, Brunt, Elizabeth M, additional, Callea, Francesco, additional, Dienes, Hans‐Peter, additional, Goodman, Zachary D, additional, Hubscher, Stefan G, additional, Kakar, Sanjay, additional, Kleiner, David E, additional, Lackner, Carolin, additional, Park, Young N, additional, Roberts, Eve A, additional, Schirmacher, Peter, additional, Terracciano, Luigi, additional, Torbenson, Michael, additional, Wanless, Ian R, additional, Zen, Yoh, additional, and Burt, Alastair D, additional

Published
2024
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4. Sonic hedgehog hepatocellular adenoma: magnetic resonance imaging features and correlation with histology

Author

Ducatel, Arnaud, primary, Trillaud, Hervé, additional, Reizine, Edouard, additional, Vilgrain, Valérie, additional, Sempoux, Christine, additional, Schmidt-Kobbe, Sabine, additional, Gouw, Annette S. H., additional, de Haas, Robbert J, additional, Julien, Céline, additional, Paradis, Valérie, additional, Blanc, Jean-Frédéric, additional, Chiche, Laurence, additional, Balabaud, Charles, additional, Bioulac-Sage, Paulette, additional, and Frulio, Nora, additional

Published
2023
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11. Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology

Author

Lohse, Ansgar W, Sebode, Marcial, Bhathal, Prithi S, Clouston, Andrew D, Dienes, Hans P, Jain, Dhanpat, Gouw, Annette S H, Guindi, Maha, Kakar, Sanjay, Kleiner, David E, Krech, Till, Lackner, Carolin, Longerich, Thomas, Saxena, Romil, Terracciano, Luigi, Washington, Kay, Weidemann, Sören, Hübscher, Stefan G, Tiniakos, Dina, and Groningen Institute for Organ Transplantation (GIOT)

Subjects
immune system diseases, digestive system diseases
Abstract

BACKGROUND & AIMS: Diagnostic histological criteria for autoimmune hepatitis (AIH) have not been clearly established. Previously published criteria focused mainly on chronic AIH, in which inflammatory changes mainly occur in portal/periportal regions and may not be applicable to acute presentation of AIH, in which inflammatory changes are typically predominantly lobular in location. International consensus criteria for the diagnosis and assessment of disease severity in both acute and chronic AIH are thus urgently needed. METHODS: Seventeen expert liver pathologists convened at an international workshop and subsequently used a modified Delphi panel approach to establish consensus criteria for the histopathological diagnosis of AIH. RESULTS: The consensus view is that liver biopsy should remain standard for diagnosing AIH. AIH is considered likely, if there is a predominantly portal lymphoplasmacytic hepatitis with more than mild interface activity and/or more than mild lobular hepatitis in the absence of histological features suggestive of another liver disease. AIH is also considered likely if there is predominantly lobular hepatitis with or without centrilobular necroinflammation and at least one of the following features: portal lymphoplasmacytic hepatitis, interface hepatitis or portal-based fibrosis, in the absence of histological features suggestive of another liver disease. Emperipolesis and hepatocellular rosettes are not regarded as being specific for AIH. CONCLUSIONS: The criteria proposed in this consensus statement provide a uniform approach to the histological diagnosis of AIH, which is relevant for patients with an acute as well as a chronic presentation and to more accurately reflect the current understanding of liver pathology in AIH.

Published
2022

13. Standardizing the histological assessment of late posttransplantation biopsies from pediatric liver allograft recipients

Author

Hübscher, Stefan G., primary, Feng, Sandy, additional, Gouw, Annette S. H., additional, Haga, Hironori, additional, Kang, Hyo Jeong, additional, Kelly, Deirdre A., additional, Komuta, Mina, additional, Lesniak, Andrew, additional, Popp, Benjamin A., additional, Verkade, Henkjan J., additional, Yu, Eunsil, additional, and Demetris, Anthony J., additional

Published
2022
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15. Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study

Author

de Vries, Elisabeth M. G., de Krijger, Manon, Färkkilä, Martti, Arola, Johanna, Schirmacher, Peter, Gotthardt, Daniel, Goeppert, Benjamin, Trivedi, Palak J., Hirschfield, Gideon M., Ytting, Henriette, Vainer, Ben, Buuren, Henk R. van, Biermann, Katharina, Harms, Maren H., Chazouilleres, Olivier, Wendum, Dominique, Kemgang, Astrid D., Chapman, Roger W., Wang, Lai Mun, Williamson, Kate D., Gouw, Annette S. H., Paradis, Valerie, Sempoux, Christine, Beuers, Ulrich, Hübscher, Stefan G., Verheij, Joanne, and Ponsioen, Cyriel Y.

Published
2017
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17. Persistent biliary hypoxia and lack of regeneration are key mechanisms in the pathogenesis of posttransplant nonanastomotic strictures

Author

de Jong, Iris E. M., primary, Overi, Diletta, additional, Carpino, Guido, additional, Gouw, Annette S. H., additional, van den Heuvel, Marius C., additional, van Kempen, Léon C., additional, Mancone, Carmine, additional, Onori, Paolo, additional, Cardinale, Vincenzo, additional, Casadei, Luca, additional, Alvaro, Domenico, additional, Porte, Robert J., additional, and Gaudio, Eugenio, additional

Published
2021
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18. Dual Versus Single Oxygenated Hypothermic Machine Perfusion of Porcine Livers: Impact on Hepatobiliary and Endothelial Cell Injury

Author

de Vries, Yvonne, primary, Brüggenwirth, Isabel M. A., additional, Karangwa, Shanice A., additional, von Meijenfeldt, Fien A., additional, van Leeuwen, Otto B., additional, Burlage, Laura C., additional, de Jong, Iris E. M., additional, Gouw, Annette S. H., additional, de Meijer, Vincent E., additional, Lisman, Ton, additional, and Porte, Robert J., additional

Published
2021
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21. Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease

Author

Lackner, Carolin Stauber, Rudolf E. Davies, Susan Denk, Helmut Dienes, Hans Peter Gnemmi, Viviane Guido, Maria and Miquel, Rosa Paradis, Valerie Schirmacher, Peter and Terracciano, Luigi Berghold, Andrea Pregartner, Gudrun and Binder, Lukas Douschan, Philipp Rainer, Florian Sygulla, Stephan Jager, Marion Rautou, Pierre-Emmanuel Bumbu, Andreea and Horhat, Adelina Rusu, Ioana Stefanescu, Horia Detlefsen, Sonke Krag, Aleksander Thiele, Maja Cortez-Pinto, Helena and Moreno, Christophe Gouw, Annette S. H. Tiniakos, Dina G.

Abstract

Background & Aims: The SALVE Histopathology Group (SHG) developed and validated a grading and staging system for the clinical and full histological spectrum of alcohol-related liver disease (ALD) and evaluated its prognostic utility in a multinational cohort of 445 patients. Methods: SALVE grade was described by semiquantitative scores for steatosis, activity (hepatocellular injury and lobular neutrophils) and cholestasis. The histological diagnosis of steatohepatitis due to ALD (histological ASH, hASH) was based on the presence of hepatocellular ballooning and lobular neutrophils. Fibrosis staging was adapted from the Clinical Research Network staging system for non-alcoholic fatty liver disease and the Laennec staging system and reflects the pattern and extent ALD fibrosis. There are 7 SALVE fibrosis stages (SFS) ranging from no fibrosis to severe cirrhosis. Results: Interobserver ic-value for each grading and staging parameter was >0.6. In the whole study cohort, long-term outcome was associated with activity grade and cholestasis, as well as cirrhosis with very broad septa (severe cirrhosis) (p

Published
2021

23. Pathology of the liver sinusoids*

Author

Brunt, Elizabeth M, Gouw, Annette S H, Hubscher, Stefan G, Tiniakos, Dina G, Bedossa, Pierre, Burt, Alastair D, Callea, Francesco, Clouston, Andrew D, Dienes, Hans P, Goodman, Zachary D, Roberts, Eve A, Roskams, Tania, Terracciano, Luigi, Torbenson, Michael S, and Wanless, Ian R

Published
2014
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25. Enrichment of the tumour immune microenvironment in patients with desmoplastic colorectal liver metastasis

Author

Höppener, Diederik J, Nierop, Pieter M H, Hof, Joost, Sideras, Kostandinos, Zhou, Guoying, Visser, Lydia, Gouw, Annette S H, de Jong, Koert P, Sprengers, Dave, Kwekkeboom, Jaap, Vermeulen, Peter B, Grünhagen, Dirk J, Verhoef, Cornelis, Höppener, Diederik J, Nierop, Pieter M H, Hof, Joost, Sideras, Kostandinos, Zhou, Guoying, Visser, Lydia, Gouw, Annette S H, de Jong, Koert P, Sprengers, Dave, Kwekkeboom, Jaap, Vermeulen, Peter B, Grünhagen, Dirk J, and Verhoef, Cornelis

Abstract

BACKGROUND: Patients with resected colorectal liver metastasis (CRLM) who display only the desmoplastic histopathological growth pattern (dHGP) exhibit superior survival compared to patients with any non-desmoplastic growth (non-dHGP). The aim of this study was to compare the tumour microenvironment between dHGP and non-dHGP.METHODS: The tumour microenvironment was investigated in three cohorts of chemo-naive patients surgically treated for CRLM. In cohort A semi-quantitative immunohistochemistry was performed, in cohort B intratumoural and peritumoural T cells were counted using immunohistochemistry and digital image analysis, and in cohort C the relative proportions of individual T cell subsets were determined by flow cytometry.RESULTS: One hundred and seventeen, 34, and 79 patients were included in cohorts A, B, and C, with dHGP being observed in 27%, 29%, and 15% of patients, respectively. Cohorts A and B independently demonstrated peritumoural and intratumoural enrichment of cytotoxic CD8+ T cells in dHGP, as well as a higher CD8+/CD4+ ratio (cohort A). Flow cytometric analysis of fresh tumour tissues in cohort C confirmed these results; dHGP was associated with higher CD8+ and lower CD4+ T cell subsets, resulting in a higher CD8+/CD4+ ratio.CONCLUSION: The tumour microenvironment of patients with dHGP is characterised by an increased and distinctly cytotoxic immune infiltrate, providing a potential explanation for their superior survival.

Published
2020

26. B Cells as Prognostic Biomarker After Surgery for Colorectal Liver Metastases

Author

Hof, Joost, Visser, Lydia, Höppener, Diederik J, Nierop, Pieter M H, Terpstra, Miente M, Gouw, Annette S H, Grünhagen, Dirk J, Verhoef, Cornelis, Sijmons, Rolf H, de Jong, Koert P, Kok, Klaas, Hof, Joost, Visser, Lydia, Höppener, Diederik J, Nierop, Pieter M H, Terpstra, Miente M, Gouw, Annette S H, Grünhagen, Dirk J, Verhoef, Cornelis, Sijmons, Rolf H, de Jong, Koert P, and Kok, Klaas

Abstract

Background: The aim of this study was to identify more accurate variables to improve prognostication of individual patients with colorectal liver metastases (CRLM). Clinicopathological characteristics only partly explain the large range in survival rates. Methods: MessengerRNA expression profiles of resected CRLM of two patient groups were analysed by mRNA sequencing: poor survivors (death from recurrent disease <30 months after surgery) and good survivors (no recurrent disease >60 months after surgery). Tumour and adjacent liver parenchyma samples were analysed. Results: MessengerRNA expression profiling of the tumour samples identified 77 genes that were differentially expressed between the two survival groups at a False Discovery Rate (FDR) <0.1. In the adjacent liver parenchyma samples only one gene, MTRNR2L1, showed significantly higher expression in the good survivors. Pathway analysis showed higher expression of immune-related and stroma-related genes in tumour samples from good survivors. Expression data was then validated by immunohistochemistry in two cohorts comprising a total of 125 patients. Immunohistochemical markers that showed to be associated with good survival in the total cohort were: high K/L+ infiltration in tumour stroma [p = 0.029; OR 2.500 (95% CI 1.100-5.682)] and high CD79A+ infiltration in tumour stroma [p = 0.036; OR 2.428 (95%CI 1.062-5.552)]. Conclusions: A high stromal infiltration of CD79A+ B cells and K/L+ plasma cells might be favourable prognostic biomarkers after surgery for CRLM.

Published
2020

37. Biliary Bicarbonate, pH, and Glucose Are Suitable Biomarkers of Biliary Viability During Ex Situ Normothermic Machine Perfusion of Human Donor Livers

Author

Matton, Alix P.M., primary, de Vries, Yvonne, additional, Burlage, Laura C., additional, van Rijn, Rianne, additional, Fujiyoshi, Masato, additional, de Meijer, Vincent E., additional, de Boer, Marieke T., additional, de Kleine, Ruben H.J., additional, Verkade, Henkjan J., additional, Gouw, Annette S. H., additional, Lisman, Ton, additional, and Porte, Robert J., additional

Published
2019
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41. Choledochal malformations in adults in the Netherlands: Results from a nationwide retrospective cohort study.

Author

Kleine, Ruben H., Schreuder, A. Marthe, Hove, Anneke, Hulscher, Jan B. F., Borel Rinkes, Inne H. M., Dejong, Cornelis H. C., Jonge, Jeroen, Reuver, Philip, Erdmann, Joris, Kazemier, Geert, Gulik, Thomas M., Gouw, Annette S. H., and Porte, Robert J.

Subjects
MEDICAL records, COHORT analysis, BILE ducts, HUMAN abnormalities, ADULTS, LIVER surgery
Abstract

Background and Aims: Patients with a choledochal malformation, formerly described as cysts, are at increased risk of developing a cholangiocarcinoma and resection is recommended. Given the low incidence of choledochal malformation (CM) in Western countries, the incidence in these countries is unclear. Our aim was to assess the incidence of malignancy in CM patients and to assess postoperative outcome. Methods: In a nationwide, retrospective study, all adult patients who underwent surgery for CM between 1990 and 2016 were included. Patients were identified through the Dutch Pathology Registry and local patient records and were analysed to determine the incidence of malignancy, as well as postoperative mortality and morbidity. Results: A total of 123 patients with a CM were included in the study (Todani Type I, n = 71; Type II, n = 10; Type III, n = 3; Type IV, n = 27; unknown, n = 12). Median age was 40 years (range 18‐70) and 81% were female. The majority of patients (99/123) underwent extrahepatic bile duct resection, with additional liver parenchyma resections in eight patients, only exploration in two, and a local cyst resection in eight patients. Postoperative 30‐day mortality was 2% (2/123) and limited to patients who underwent liver resection. Severe morbidity occurred in 24%. In 14 of the 123 patients (11%), a malignancy was found in the resected specimen. One patient developed a periampullary malignancy 7 years later. Conclusions: In a large Western series of CM patients, 11% were found to have a malignancy. This justifies resection in these patients, despite the risk of morbidity (24%) and mortality (2%). [ABSTRACT FROM AUTHOR]

Published
2020
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42. Clinicopathological features of Bu Gu Zhi‐induced liver injury, a long‐term follow‐up cohort study.

Author

Wang, Lan, Wang, Yan, Wee, Aileen, Soon, Gwyneth, Gouw, Annette S. H., Yang, Ruiyuan, Tian, Qiuju, Liu, Liwei, Ma, Hong, and Zhao, Xinyan

Subjects
LIVER injuries, ASPARTATE aminotransferase, ALANINE aminotransferase, COHORT analysis, APPETITE loss
Abstract

Background & Aims: Bu Gu Zhi (BGZ) is a Chinese herb consumed mainly for osteoporosis treatment. Only small case series of BGZ‐induced liver injury (BGZILI) have been reported. We describe the clinicopathological features and clinical course of BGZILI. Methods: Patients diagnosed with drug‐induced liver injury (DILI) at Beijing Friendship Hospital from 2005 to 2017 were reviewed. Clinical and follow‐up data were analysed. Results: Of the 547 DILI patients, 40 cases (7.3%) were attributed to BGZILI. About 34/40 (85.0%) patients were females with a median age of 63 (range, 54‐70) years. The median latency period was 45 (range, 29‐90) days. Patients commonly presented with loss of appetite (57.5%), dark urine (57.5%) and fatigue (55.0%). The median level of alanine aminotransferase and aspartate aminotransferase at BGZILI onset was 673.5 and 423.0 U/L respectively. Total bilirubin (TB) and direct bilirubin (DB) were 59.0 and 39.4 µmol/L respectively. The biochemical liver injury pattern was hepatocellular (92.5%), cholestatic (5.0%) and mixed (2.5%). They were categorized into 'mild' (N = 23, 57.5%), 'moderate' (6, 15.0%) or 'severe' (11, 27.5%) according to severity assessment by DILI network. The main histological injury pattern in 9/40 patients with liver biopsy was acute hepatitis with/without cholestasis. Median duration of follow‐up was 26.3 months with recovery in 37 patients within 6 months. No patients died or required transplantation. Conclusions: BGZ‐induced liver injury manifested more often as a hepatocellular injury pattern with mild to moderate hepatocellular damage. Most patients recovered after cessation of BGZ within 6 months, and none developed end‐stage liver disease or died. [ABSTRACT FROM AUTHOR]

Published
2020
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43. Limited diagnostic accuracy and clinical impact of single-operator peroral cholangioscopy for indeterminate biliary strictures.

Author

de Vries, Adriaan B., van der Heide, Frans, ter Steege, Rinze W. F., Koornstra, Jan Jacob, Buddingh, Karel T., Gouw, Annette S. H., and Weersma, Rinse K.

Subjects
CHOLANGITIS, CHOLANGIOSCOPY, MEDICAL records, CHANGE management, CYTOLOGY, BILE duct tumors, CHOLANGIOCARCINOMA, STENOSIS, ENDOSCOPIC retrograde cholangiopancreatography, RETROSPECTIVE studies, DIGESTIVE system endoscopic surgery, BILE ducts, DISEASE complications
Abstract

Background: Single-operator peroral cholangioscopy (sPOCS) is considered a valuable diagnostic modality for indeterminate biliary strictures. Nevertheless, studies show large variation in its characteristics and measures of diagnostic accuracy. Our aim was to estimate the diagnostic accuracy of sPOCS visual assessment and targeted biopsies for indeterminate biliary strictures. Additional aims were: estimation of the clinical impact of sPOCS and comparison of diagnostic accuracy with brush cytology.Methods: A retrospective single-center study of adult patients who underwent sPOCS for indeterminate biliary strictures was performed. Diagnostic accuracy was defined as sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). The clinical impact of sPOCS was assessed by review of medical records, and classified according to its influence on patient management.Results: 80 patients were included, with 40 % having primary sclerosing cholangitis (PSC). Prior ERCP was performed in 88 %, with removal of a biliary stent prior to sPOCS in 55 %. The sensitivity, specificity, PPV, and NPV for sPOCS visual impression and targeted biopsies were 64 %, 62 %, 41 %, and 84 %, and 15 %, 65 %, 75 %, and 69 %, respectively. The clinical impact of sPOCS was limited; outcome changed management in 17 % of patients. Sequential brush cytology sensitivity, specificity, PPV, and NPV were 47 %, 95 %, 80 %, and 83 %.Conclusions: The diagnostic accuracy of sPOCS for indeterminate biliary strictures was found to be inferior to brush cytology, with a low impact on patient management. These findings are obtained from a select patient population with a high prevalence of PSC and plastic stents in situ prior to sPOCS. [ABSTRACT FROM AUTHOR]

Published
2020
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44. Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers

Author

van Rijn, Rianne, primary, van Leeuwen, Otto B., additional, Matton, Alix P. M., additional, Burlage, Laura C., additional, Wiersema‐Buist, Janneke, additional, van den Heuvel, Marius C., additional, de Kleine, Ruben H. J., additional, de Boer, Marieke T., additional, Gouw, Annette S. H., additional, and Porte, Robert J., additional

Published
2018
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45. Normothermic machine perfusion of donor livers without the need for human blood products

Author

Matton, Alix P. M., primary, Burlage, Laura C., additional, van Rijn, Rianne, additional, de Vries, Yvonne, additional, Karangwa, Shanice A., additional, Nijsten, Maarten W., additional, Gouw, Annette S. H., additional, Wiersema‐Buist, Janneke, additional, Adelmeijer, Jelle, additional, Westerkamp, Andrie C., additional, Lisman, Ton, additional, and Porte, Robert J., additional

Published
2018
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47. Markers of Angiogenesis in Synchronous and in Metachronous Colorectal Hepatic Metastases Reply

Author

van der Wal, Gesiena E., Gouw, Annette S. H., Kamps, Jan A. A. M., Moorlag, Henk E., Bulthuis, Marian L. C., Molema, Grietje, de Jong, Koert P., Nanotechnology and Biophysics in Medicine (NANOBIOMED), Vascular Ageing Programme (VAP), Groningen Institute for Organ Transplantation (GIOT), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Kidney Center (GKC), and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Subjects
GROWTH, CANCER, LIVER METASTASES
Published
2015

49. Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers

Author

Westerkamp, Andrie C., primary, Karimian, Negin, additional, Matton, Alix P. M., additional, Mahboub, Paria, additional, van Rijn, Rianne, additional, Wiersema-Buist, Janneke, additional, de Boer, Marieke T., additional, Leuvenink, Henri G. D., additional, Gouw, Annette S. H., additional, Lisman, Ton, additional, and Porte, Robert J., additional

Published
2016
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