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The present work aimed to develop a suitable, specific, simple, precise, robust, and reproducible analytical method using RP-HPLC for simultaneous estimation of Ipratropium bromide and Mometasone furoate. The separation was carried out using mobile phase Acetonitrile: Phosphate buffer (pH modified up to 3.7 by orthophosphoric acid) in the ratio of 50:50 % v/v at 1 ml/min flow rate and detection was carried out at 210 nm. The method was validated by determining system specificity, selectivity, suitability, linearity, precision, accuracy, robustness, and LOQ-LOD as per ICH Q2 (R1) guidelines. The developed method was found to be suitable for the routine quantitative analysis of Ipratropium bromide and Mometasone furoate in bulk and pharmaceutical dosage forms. It was also concluded that the developed method was accurate, precise, linear, reproducible, robust, and sensitive. [ABSTRACT FROM AUTHOR]

This study aims to compare the frictional resistance of active (TIME- 2, IN-OVATION R) and passive (DAMON SL-2, SMART CLIP) self- ligating brackets with conventional TITANIUM, FIBREGLASS and CERAMIC brackets under dry and wet conditions with artificial saliva using universal testing machine. A total of 200 samples were tested of which 80 were self- ligating and 120 were conventional brackets.. Specimens were divided into 2 categories which were run under dry and wet conditions, using artificial saliva.10 samples of each active and passive self-ligating brackets were dry run and 10 others were used in wet conditions. 10 samples of each CERAMIC, TITANIUM and FIBRE GLASS brackets were run using elastomeric ties in both dry and wet conditions and 10 each of them using stainless steel ligatures under dry and wet conditions. The study revealed that the least frictional resistance was demonstrated by the brackets in the following order i.e. PASSIVE SELF- LIGATING BRACKETS, ACTIVE SELF- LIGATING BRACKETS, TITANIUM, FIBREGLASS and CERAMIC brackets in both dry and wet conditions. Paired t-test, two sample t-test, and Analysis of variance were done to evaluate the results statistically. Surface topography of the brackets slots in higher magnification(X 500 at 20kv) under scanning electron micrographs also confirmed the same results. The self-ligating brackets seems to be functionally efficient with reduced friction, aesthetically pleasing, reduced treatment and chair side time, combined with better oral hygiene maintenance and patient comfort because of absence of ligation. [ABSTRACT FROM AUTHOR]