28 results on '"Geissler, Wayne M."'
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2. Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants
3. Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization
4. Modeling aided design of potent glycogen phosphorylase inhibitors
5. Amino acid substitution of arginine 80 in 17β-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics
6. Development of a novel tricyclic class of potent and selective FIXa inhibitors
7. Development of a novel class of potent and selective FIXa inhibitors
8. Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors
9. Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure–Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program
10. A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation
11. A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes
12. The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors
13. Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.
14. Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase
15. Design and Synthesis of Prolylcarboxypeptidase (PrCP) Inhibitors To Validate PrCP As A Potential Target for Obesity
16. Expression, purification and crystallization of human prolylcarboxypeptidase
17. Novel 3,4‐Dihydroquinolin‐2(1H)‐one Inhibitors of Human Glycogen Phosphorylase a.
18. Glucose-Lowering in a db/db Mouse Model by Dihydropyridine Diacid Glycogen Phosphorylase Inhibitors.
19. Novel 3,4-Dihydroquinolin-2(1 H )-one inhibitors of human glycogen phosphorylase a
20. A new class of glycogen phosphorylase inhibitors
21. Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors
22. The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1
23. Cloning and expression of Staphylococcus aureus and Streptococcus pyogenes murD genes encoding uridine diphosphate N-acetylmuramoyl-l-alanine:d-glutamate ligases
24. Hepatic responses to inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase: a comparison of atorvastatin and simvastatin
25. The molecular biology of androgenic 17β-hydroxysteroid dehydrogenases
26. Male pseudohermaphroditism caused by mutations of testicular 17β–hydroxysteroid dehydrogenase 3
27. Novel 3,4-Dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a
28. Enzymatic preparation of high-specific-activity β-d-[6,6′-3H]fructose-2,6-bisphosphate: Application to a sensitive assay for fructose-2,6-bisphosphatase
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