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4. Radiomics-enhanced early regression index for predicting treatment response in rectal cancer: a multi-institutional 0.35 T MRI-guided radiotherapy study

Author

Boldrini, Luca, Chiloiro, Giuditta, Cusumano, Davide, Yadav, Poonam, Yu, Gao, Romano, Angela, Piras, Antonio, Votta, Claudio, Placidi, Lorenzo, Broggi, Sara, Catucci, Francesco, Lenkowicz, Jacopo, Indovina, Luca, Bassetti, Michael F., Yang, Yingli, Fiorino, Claudio, Valentini, Vincenzo, and Gambacorta, Maria Antonietta

Published
2024
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5. Error-Correcting Methodology for Evaluating Compliance to Clinical Guidelines: A Case Study on Rectal Cancer

Author

Savino, Mariachiara, Fernandez-Llatas, Carlos, Gatta, Roberto, Chiloiro, Giuditta, Di Franco, Silvia, Ibanez-Sanchez, Gema, Valero-Ramon, Zoe, Gambacorta, Maria Antonietta, Valentini, Vincenzo, Damiani, Andrea, van der Aalst, Wil, Series Editor, Ram, Sudha, Series Editor, Rosemann, Michael, Series Editor, Szyperski, Clemens, Series Editor, Guizzardi, Giancarlo, Series Editor, De Smedt, Johannes, editor, and Soffer, Pnina, editor

Published
2024
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6. Definitive chemoradiation in vulvar squamous cell carcinoma: outcome and toxicity from an observational multicenter Italian study on vulvar cancer (OLDLADY 1.1)

Author

Macchia, Gabriella, Lancellotta, Valentina, Ferioli, Martina, Casà, Calogero, Pezzulla, Donato, Pappalardi, Brigida, Laliscia, Concetta, Ippolito, Edy, Di Muzio, Jacopo, Huscher, Alessandra, Tortoreto, Francesca, Boccardi, Mariangela, Lazzari, Roberta, Perrone, Anna Myriam, Raspagliesi, Francesco, Gadducci, Angiolo, Garganese, Giorgia, Fragomeni, Simona Maria, Ferrandina, Gabriella, Morganti, Alessio Giuseppe, Gambacorta, Maria Antonietta, and Tagliaferri, Luca

Published
2024
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9. Impact of body composition parameters on radiation therapy compliance in locally advanced rectal cancer: A retrospective observational analysis

Author

Chiloiro, Giuditta, Cintoni, Marco, Palombaro, Marta, Romano, Angela, Reina, Sara, Pulcini, Gabriele, Corvari, Barbara, Di Franco, Silvia, Meldolesi, Elisa, Egidi, Gabriele, Grassi, Futura, Raoul, Pauline, Rinninella, Emanuele, Gasbarrini, Antonio, Mele, Maria Cristina, and Gambacorta, Maria Antonietta

Published
2024
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11. May we routinely spare hippocampal region in primary central nervous system lymphoma during whole brain radiotherapy?

Author

Mazzarella, Ciro, Chiesa, Silvia, Toppi, Lucrezia, Hohaus, Stefan, Gaudino, Simona, D’Alo, Francesco, Dinapoli, Nicola, Davide, Resta, Zinicola, Tiziano, Bracci, Serena, Martino, Antonella, Beghella Bartoli, Francesco, Lepre, Elisabetta, Bertolini, Roberta, Mariani, Silvia, Colosimo, Cesare, Frascino, Vincenzo, Mattiucci, Gian Carlo, Gambacorta, Maria Antonietta, Valentini, Vincenzo, and Balducci, Mario

Published
2023
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12. The Italian version of the Pediatric Quality of Life Inventory™ (PEDSQL™) 3.0 healthcare satisfaction hematology/oncology module: reliability and validity in radiation oncology

Author

Marconi, Elisa, Beghella Bartoli, Francesco, Meldolesi, Elisa, Mariani, Silvia, Panza, Giulia, Nardangeli, Alessia, Dinapoli, Loredana, Lees, Teresa Carmen, Guido, Antonella, Mastronuzzi, Angela, Ruggiero, Antonio, Gambacorta, Maria Antonietta, Valentini, Vincenzo, Balducci, Mario, Chieffo, Daniela Pia Rosaria, and Chiesa, Silvia

Published
2023
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14. Magnetic resonance guided SBRT reirradiation in locally recurrent prostate cancer: a multicentric retrospective analysis

Author

Boldrini, Luca, Romano, Angela, Chiloiro, Giuditta, Corradini, Stefanie, De Luca, Viola, Verusio, Valeria, D’Aviero, Andrea, Castelluccia, Alessandra, Alitto, Anna Rita, Catucci, Francesco, Grimaldi, Gianmarco, Trapp, Christian, Hörner-Rieber, Juliane, Marchesano, Domenico, Frascino, Vincenzo, Mattiucci, Gian Carlo, Valentini, Vincenzo, Gentile, Piercarlo, and Gambacorta, Maria Antonietta

Published
2023
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15. Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group

Author

Mantello, Giovanna, Galofaro, Elena, Caravatta, Luciana, Di Carlo, Clelia, Montrone, Sabrina, Arpa, Donatella, Chiloiro, Giuditta, De Paoli, Antonino, Donato, Vittorio, Gambacorta, Maria Antonietta, Genovesi, Domenico, Lupattelli, Marco, Macchia, Gabriella, Montesi, Giampaolo, Niespolo, Rita Marina, Palazzari, Elisa, Pontoriero, Antonio, Scricciolo, Melissa, Valvo, Francesca, and Franco, Pierfrancesco

Published
2023
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16. Efficacy of stereotactic body radiotherapy and response prediction using artificial intelligence in oligometastatic gynaecologic cancer

Author

Macchia, Gabriella, Cilla, Savino, Pezzulla, Donato, Campitelli, Maura, Laliscia, Concetta, Lazzari, Roberta, Draghini, Lorena, Fodor, Andrei, D'Agostino, Giuseppe R., Russo, Donatella, Balcet, Vittoria, Ferioli, Martina, Vicenzi, Lisa, Raguso, Arcangela, Di Cataldo, Vanessa, Perrucci, Elisabetta, Borghesi, Simona, Ippolito, Edy, Gentile, Piercarlo, De Sanctis, Vitaliana, Titone, Francesca, Delle Curti, Clelia Teresa, Huscher, Alessandra, Gambacorta, Maria Antonietta, Ferrandina, Gabriella, Morganti, Alessio G., and Deodato, Francesco

Published
2024
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17. External beam radiotherapy boost versus surgical debulking followed by radiotherapy for the treatment of metastatic lymph nodes in cervical cancer: A systematic review and meta-analysis

Author

Bizzarri, Nicolò, Di Berardino, Stefano, Benkortbi, Khadidja, Balaya, Vincent, Gambacorta, Maria Antonietta, Macchia, Gabriella, Boulvain, Michel, Feki, Anis, Mathevet, Patrice, Lecuru, Fabrice, Querleu, Denis, Ferrandina, Gabriella, Scambia, Giovanni, and Guani, Benedetta

Published
2024
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21. Rectal Cancer

Author

Fokas, Emmanouil, Gani, Cihan, Valentini, Vincenzo, Rödel, Claus, Gambacorta, Maria Antonietta, Grosu, Anca-Ligia, editor, Nieder, Carsten, editor, and Nicolay, Nils Henrik, editor

Published
2023
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23. Stereotactic Ablative Radiation Therapy for Oligometastatic Ovarian Cancer Lymph Node Disease: The MITO-RT3/RAD Phase II Trial

Author

Macchia, Gabriella, Campitelli, Maura, Pezzulla, Donato, Lucci, Simona, Fodor, Andrei, Russo, Donatella, Balcet, Vittoria, Bonome, Paolo, Durante, Stefano, Draghini, Lorena, Titone, Francesca, D'Agostino, Giuseppe Roberto, Tamburo, Marinella, Ferioli, Martina, Ippolito, Edy, Tortoreto, Francesca, Caravatta, Luciana, De Felice, Francesca, Stefano, Aida Di, Fanelli, Mara, Cilla, Savino, Cosentino, Francesco, Marchetti, Claudia, Salutari, Vanda, Boccia, Serena, Morganti, Alessio Giuseppe, Gambacorta, Maria Antonietta, Fagotti, Anna, Pignata, Sandro, Scambia, Giovanni, Ferrandina, Gabriella, and Deodato, Francesco

Published
2024
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24. Stereotactic Body Radiation Therapy for Oligoprogressive Ovarian Cancer Patients Treated During Poly(ADP‐Ribose)‐Polymerase Inhibitor Maintenance: Efficacy and Adverse Events From the Epimetheo Retrospective Study

Author

Macchia, Gabriella, Pezzulla, Donato, Campitelli, Maura, Russo, Donatella, Ronzino, Graziana, Lucci, Simona, Salutari, Vanda, Di Stefano, Aida, Balcet, Vittoria, Epifani, Valeria, Perrucci, Elisabetta, Marchetti, Claudia, Distefano, Maria Grazia, Palluzzi, Eleonora, Autorino, Rosa, De Luca, Viola, Giannini, Roberta, Rinaldi, Raffaella, Russo, Silvio Andrea, Cilla, Savino, Fagotti, Anna, Gambacorta, Maria Antonietta, Scambia, Giovanni, Deodato, Francesco, and Ferrandina, Gabriella

Published
2024
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27. Efficacy and Safety of Stereotactic Body Radiation Therapy in Oligometastatic Uterine Cancer (MITO-RT2/RAD): A Large, Real-World Study in Collaboration With Italian Association of Radiation Oncology, Multicenter Italian Trials in Ovarian Cancer, and Mario Negri Gynecologic Oncology Group Groups

Author

Macchia, Gabriella, Pezzulla, Donato, Campitelli, Maura, Laliscia, Concetta, Fodor, Andrei, Bonome, Paolo, Draghini, Lorena, Ippolito, Edy, De Sanctis, Vitaliana, Ferioli, Martina, Titone, Francesca, Balcet, Vittoria, Di Cataldo, Vanessa, Russo, Donatella, Vicenzi, Lisa, Cossa, Sabrina, Lucci, Simona, Cilla, Savino, Deodato, Francesco, Gambacorta, Maria Antonietta, Scambia, Giovanni, Morganti, Alessio Giuseppe, and Ferrandina, Gabriella

Published
2023
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29. Predictive and prognostic value of inflammatory markers in locally advanced rectal cancer (PILLAR) – A multicentric analysis by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Study Group

Author

Chiloiro, Giuditta, Romano, Angela, Mariani, Silvia, Macchia, Gabriella, Giannarelli, Diana, Caravatta, Luciana, Franco, Pierfrancesco, Boldrini, Luca, Arcelli, Alessandra, Bacigalupo, Almalina, Belgioia, Liliana, Fontana, Antonella, Meldolesi, Elisa, Montesi, Giampaolo, Niespolo, Rita Marina, Palazzari, Elisa, Piva, Cristina, Valentini, Vincenzo, and Gambacorta, Maria Antonietta

Published
2023
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30. A predictive model of polymetastatic disease from a multicenter large retrospectIve database on colorectal lung metastases treated with stereotactic ablative radiotherapy: The RED LaIT-SABR study

Author

Nicosia, Luca, Franceschini, Davide, Perrone-Congedi, Francesca, Molinari, Alessandro, Gerardi, Marianna Alessandra, Rigo, Michele, Mazzola, Rosario, Perna, Marco, Scotti, Vieri, Fodor, Andrei, Iurato, Aurelia, Pasqualetti, Francesco, Gadducci, Giovanni, Chiesa, Silvia, Niespolo, Rita Marina, Bruni, Alessio, Cappelli, Anna, D'Angelo, Elisa, Borghetti, Paolo, Di Marzo, Alessandro, Ravasio, Andrea, De Bari, Berardino, Sepulcri, Matteo, Aiello, Dario, Mortellaro, Gianluca, Sangalli, Claudia, Franceschini, Marzia, Montesi, Giampaolo, Aquilanti, Francesco Maria, Lunardi, Gianluigi, Valdagni, Riccardo, Fazio, Ivan, Scarzello, Giovanni, Vavassori, Vittorio, Maranzano, Ernesto, Maria Magrini, Stefano, Arcangeli, Stefano, Gambacorta, Maria Antonietta, Valentini, Vincenzo, Paiar, Fabiola, Ramella, Sara, Di Muzio, Nadia Gisella, Loi, Mauro, Jereczek-Fossa, Barbara Alicja, Casamassima, Franco, Osti, Mattia Falchetto, Scorsetti, Marta, and Alongi, Filippo

Published
2023
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31. Psychological Experiences of Parents of Pediatric Cancer Patients during and after COVID-19 Pandemic

Author

Guido, Antonella, Marconi, Elisa, Peruzzi, Laura, Dinapoli, Nicola, Tamburrini, Gianpiero, Attinà, Giorgio, Romano, Alberto, Maurizi, Palma, Mastrangelo, Stefano, Chiesa, Silvia, Gambacorta, Maria Antonietta, Ruggiero, Antonio, Chieffo, Daniela Pia Rosaria, Marconi, Elisa (ORCID:0000-0001-6722-8390), Tamburrini, Gianpiero (ORCID:0000-0002-7139-5711), Maurizi, Palma (ORCID:0000-0002-5930-0193), Mastrangelo, Stefano (ORCID:0000-0002-3305-6014), Chiesa, Silvia (ORCID:0000-0003-0168-3459), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Ruggiero, Antonio (ORCID:0000-0002-6052-3511), Guido, Antonella, Marconi, Elisa, Peruzzi, Laura, Dinapoli, Nicola, Tamburrini, Gianpiero, Attinà, Giorgio, Romano, Alberto, Maurizi, Palma, Mastrangelo, Stefano, Chiesa, Silvia, Gambacorta, Maria Antonietta, Ruggiero, Antonio, Chieffo, Daniela Pia Rosaria, Marconi, Elisa (ORCID:0000-0001-6722-8390), Tamburrini, Gianpiero (ORCID:0000-0002-7139-5711), Maurizi, Palma (ORCID:0000-0002-5930-0193), Mastrangelo, Stefano (ORCID:0000-0002-3305-6014), Chiesa, Silvia (ORCID:0000-0003-0168-3459), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), and Ruggiero, Antonio (ORCID:0000-0002-6052-3511)

Abstract

This study aimed to evaluate how the COVID-19 pandemic affected the psychological well-being of parents of pediatric oncology patients two years after the pandemic started. The authors' objective was to make a detailed comparison between the data collected in the current study and the data gathered in the previous research with the aim of observing any changes, whether for better or worse, at the psychological level in the caregivers of the patients in question. This research could be of great use for monitoring the psychological health of the sample and for being able to intervene promptly in the event of the worsening of the reported symptoms. Background: Family members dealing with the devastating impact of a cancer diagnosis are now facing even greater vulnerability due to the COVID-19 pandemic. Alongside the already overwhelming trauma, they must also bear the distressing burden of the infection risks. The purpose of this study was to examine and explore the effects in parents of pediatric cancer patients two years after the start of the COVID-19 pandemic to compare these data with the previous data. Methods: We conducted a single-center prospective observational study, enrolling 75 parents of 42 pediatric oncology patients. Four questionnaires (IES-R; PSS; STAI-Y and PedsQL) were given to the parents 2 years after the first evaluation. Results: The bivariate matrix of correlation found a strong significant positive correlation between IES-R and PSS scores (r = 0.526, p < 0.001) as in T1. Stress symptoms (t = 0.00, p < 0.001) and levels of anxiety (trait) (t = 0.32, p < 0.001) remained unchanged; anxiety state levels appeared to have increased (t = 0.425, p < 0.001); there was a significant decrease in the PedsQL tot (t = 5.25, p < 0.001). Conclusions: The COVID-19 pandemic has influenced the levels of stress and anxiety of parents and the quality of life of patients, also correlating with the traumatic impact of the diagnosis.

Published
2024

32. Is PET Radiomics Useful to Predict Pathologic Tumor Response and Prognosis in Locally Advanced Cervical Cancer?

Author

Collarino, Angela, Feudo, Vanessa, Pasciuto, Tina, Florit, Anita, Pfaehler, Elisabeth, de Summa, Marco, Bizzarri, Nicolò, Annunziata, Salvatore, Zannoni, Gian Franco, de Geus-Oei, Lioe-Fee, Ferrandina, Maria Gabriella, Gambacorta, Maria Antonietta, Scambia, Giovanni, Boellaard, Ronald, Sala, Evi, Rufini, Vittoria, van Velden, Floris HP, Pasciuto, Tina (ORCID:0000-0003-2959-8571), Annunziata, Salvatore (ORCID:0000-0003-3241-1501), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Sala, Evis, Rufini, Vittoria (ORCID:0000-0002-2052-8078), Collarino, Angela, Feudo, Vanessa, Pasciuto, Tina, Florit, Anita, Pfaehler, Elisabeth, de Summa, Marco, Bizzarri, Nicolò, Annunziata, Salvatore, Zannoni, Gian Franco, de Geus-Oei, Lioe-Fee, Ferrandina, Maria Gabriella, Gambacorta, Maria Antonietta, Scambia, Giovanni, Boellaard, Ronald, Sala, Evi, Rufini, Vittoria, van Velden, Floris HP, Pasciuto, Tina (ORCID:0000-0003-2959-8571), Annunziata, Salvatore (ORCID:0000-0003-3241-1501), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Sala, Evis, and Rufini, Vittoria (ORCID:0000-0002-2052-8078)

Abstract

This study investigated whether radiomic features extracted from pretreatment [18F]FDG PET could improve the prediction of both histopathologic tumor response and survival in patients with locally advanced cervical cancer (LACC) treated with neoadjuvant chemoradiotherapy followed by surgery compared with conventional PET parameters and histopathologic features. Methods: The medical records of all consecutive patients with LACC referred between July 2010 and July 2016 were reviewed. [18F]FDG PET/CT was performed before neoadjuvant chemoradiotherapy. Radiomic features were extracted from the primary tumor volumes delineated semiautomatically on the PET images and reduced by factor analysis. A receiver-operating-characteristic analysis was performed, and conventional and radiomic features were dichotomized with Liu's method according to pathologic response (pR) and cancer-specific death. According to the study protocol, only areas under the curve of more than 0.70 were selected for further analysis, including logistic regression analysis for response prediction and Cox regression analysis for survival prediction. Results: A total of 195 patients fulfilled the inclusion criteria. At pathologic evaluation after surgery, 131 patients (67.2%) had no or microscopic (≤3 mm) residual tumor (pR0 or pR1, respectively); 64 patients (32.8%) had macroscopic residual tumor (>3 mm, pR2). With a median follow-up of 76.0 mo (95% CI, 70.7-78.7 mo), 31.3% of patients had recurrence or progression and 20.0% died of the disease. Among conventional PET parameters, SUVmean significantly differed between pathologic responders and nonresponders. Among radiomic features, 1 shape and 3 textural features significantly differed between pathologic responders and nonresponders. Three radiomic features significantly differed between presence and absence of recurrence or progression and between presence and absence of cancer-specific death. Areas under the curve were less than 0.70 for all param

Published
2024

33. Simultaneous Integrated Boost (Sib) Intensity-Modulated Radiotherapy for Treatment of Bone Metastases: Analysis of a Breast Cancer Cohort

Author

Marazzi, Fabio, primary, Masiello, Valeria, additional, Fabi, Alessandra, additional, Manfrida, Stefania, additional, Corvari, Barbara, additional, Lancellotta, Valentina, additional, Mazzarella, Ciro, additional, Longo, Silvia, additional, De Angeli, Martina, additional, Moschella, Francesca, additional, Di Leone, Alba, additional, Orlandi, Armando, additional, Bracci, Serena, additional, Colloca, Giuseppe Ferdinando, additional, Massaccesi, Mariangela, additional, Boldrini, Luca, additional, Tagliaferri, Luca, additional, Franceschini, Gianluca, additional, Bria, Emilio, additional, Masetti, Riccardo, additional, Valentini, Vincenzo, additional, Gambacorta, Maria Antonietta, additional, and CELLINI, Francesco, additional

Published
2024
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35. EROS 2.0 study: evaluation of two interventional radiotherapy (brachytherapy) schedules for endometrial cancer: a comparison of late vaginal toxicity rates

Author

Lancellotta, Valentina, Macchia, Gabriella, Dinapoli, Nicola, Autorino, Rosa, Campitelli, Maura, Nardangeli, Alessia, Salvati, Alessandra, Fionda, Bruno, Casà, Calogero, Cornacchione, Patrizia, Rovirosa, Angeles, Kovács, György, Morganti, Alessio Giuseppe, Ferrandina, Maria Gabriella, Gambacorta, Maria Antonietta, and Tagliaferri, Luca

Published
2022
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36. Rectal Sparing Approach After Neoadjuvant Therapy in Patients with Rectal Cancer: The Preliminary Results of the ReSARCh Trial

Author

Marchegiani, Francesco, Palatucci, Valeria, Capelli, Giulia, Guerrieri, Mario, Belluco, Claudio, Rega, Daniela, Morpurgo, Emilio, Coco, Claudio, Restivo, Angelo, De Franciscis, Silvia, Aschele, Carlo, Perin, Alessandro, Bonomo, Michele, Muratore, Andrea, Spinelli, Antonino, Ramuscello, Salvatore, Bergamo, Francesca, Montesi, Giampaolo, Spolverato, Gaya, Del Bianco, Paola, Gambacorta, Maria Antonietta, Delrio, Paolo, and Pucciarelli, Salvatore

Published
2022
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38. Development and validation of prognostic models for anal cancer outcomes using distributed learning: protocol for the international multi-centre atomCAT2 study

Author

Theophanous, Stelios, Lønne, Per-Ivar, Choudhury, Ananya, Berbee, Maaike, Dekker, Andre, Dennis, Kristopher, Dewdney, Alice, Gambacorta, Maria Antonietta, Gilbert, Alexandra, Guren, Marianne Grønlie, Holloway, Lois, Jadon, Rashmi, Kochhar, Rohit, Mohamed, Ahmed Allam, Muirhead, Rebecca, Parés, Oriol, Raszewski, Lukasz, Roy, Rajarshi, Scarsbrook, Andrew, Sebag-Montefiore, David, Spezi, Emiliano, Spindler, Karen-Lise Garm, van Triest, Baukelien, Vassiliou, Vassilios, Malinen, Eirik, Wee, Leonard, and Appelt, Ane L.

Published
2022
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39. THUNDER 2: THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI guided radiotherapy

Author

Chiloiro, Giuditta, Cusumano, Davide, Boldrini, Luca, Romano, Angela, Placidi, Lorenzo, Nardini, Matteo, Meldolesi, Elisa, Barbaro, Brunella, Coco, Claudio, Crucitti, Antonio, Persiani, Roberto, Petruzziello, Lucio, Ricci, Riccardo, Salvatore, Lisa, Sofo, Luigi, Alfieri, Sergio, Manfredi, Riccardo, Valentini, Vincenzo, and Gambacorta, Maria Antonietta

Published
2022
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41. Privacy-friendly evaluation of patient data with secure multiparty computation in a European pilot study.

Author

Ballhausen, Hendrik, Corradini, Stefanie, Belka, Claus, Bogdanov, Dan, Boldrini, Luca, Bono, Francesco, Goelz, Christian, Landry, Guillaume, Panza, Giulia, Parodi, Katia, Talviste, Riivo, Tran, Huong Elena, Gambacorta, Maria Antonietta, and Marschner, Sebastian

Subjects
DATA security, STATISTICAL power analysis, MEDICAL informatics, RESEARCH funding, ACADEMIC medical centers, PRIVACY, CLINICAL medicine research, PILOT projects, PATHOLOGIC complete response, SCIENTIFIC observation, CANCER patients, TREATMENT effectiveness, DESCRIPTIVE statistics, CHI-squared test, METASTASIS, KAPLAN-Meier estimator, LONGITUDINAL method, ADRENAL tumors, CONFIDENCE intervals, RADIATION doses, MEDICAL ethics, GOVERNMENT regulation
Abstract

In multicentric studies, data sharing between institutions might negatively impact patient privacy or data security. An alternative is federated analysis by secure multiparty computation. This pilot study demonstrates an architecture and implementation addressing both technical challenges and legal difficulties in the particularly demanding setting of clinical research on cancer patients within the strict European regulation on patient privacy and data protection: 24 patients from LMU University Hospital in Munich, Germany, and 24 patients from Policlinico Universitario Fondazione Agostino Gemelli, Rome, Italy, were treated for adrenal gland metastasis with typically 40 Gy in 3 or 5 fractions of online-adaptive radiotherapy guided by real-time MR. High local control (21% complete remission, 27% partial remission, 40% stable disease) and low toxicity (73% reporting no toxicity) were observed. Median overall survival was 19 months. Federated analysis was found to improve clinical science through privacy-friendly evaluation of patient data in the European health data space. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Optimal Sequence for Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: An Evidence‐Based Review.

Author

Ghalehtaki, Reza, Nourbakhsh, Forouzan, Abyaneh, Romina, Sharifian, Azadeh, Pashapour‐Khoyi, Sheyda, Aghili, Mahdi, Gambacorta, Maria Antonietta, and Couñago, Felipe

Subjects
TUMOR classification, CONSOLIDATION chemotherapy, INDUCTION chemotherapy, ADJUVANT chemotherapy, NEOADJUVANT chemotherapy, RECTAL cancer
Abstract

Introduction: Historically, multimodal therapeutic strategies involving preoperative chemoradiotherapy (CRT), surgery, and adjuvant chemotherapy (CT) have been employed to treat locally advanced rectal cancer (LARC). Total Neoadjuvant Therapy (TNT) is showing promise in improving outcomes. Despite its benefits, the optimal sequencing within TNT—whether induction chemotherapy should precede or follow chemoradiotherapy—remains a critical question. This study endeavors to explore the effects of different TNT sequencing strategies on patient outcomes, including tumor downstaging, pathological response, organ preservation, and the balance between efficacy and tolerability. Methods: Our methodology entailed a comprehensive literature review conducted on Medline, focusing on recent research, including retrospective studies, systematic reviews, and clinical trials. The review emphasized the comparison of induction chemotherapy versus consolidation chemotherapy within TNT regimens, assessing outcomes such as pathological response, organ preservation rates, and adverse effects. To ensure the selection of appropriate and high‐quality studies, specific inclusion and exclusion criteria were applied. Results: The analysis revealed that induction chemotherapy might lead to decreased adherence to subsequent chemoradiotherapy while offering an early intervention against micrometastasis and potentially improving overall chemotherapy compliance. Conversely, consolidation chemotherapy has been associated with higher pathological complete response (pCR) rates and improved tolerability, indicating its potential for patients requiring local symptom relief or those eligible for a nonoperative management approach. Comparative studies like CAO/ARO/AIO‐12 and the OPRA trials have significantly contributed to our understanding, suggesting that while both strategies have distinct advantages, the choice between induction and consolidation chemotherapy should be tailored based on individual patient profiles and tumor characteristics. Conclusion: This narrative review underscores the importance of a nuanced approach to TNT sequencing in locally advanced rectal cancer, highlighting the need for further research to refine treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Palliative radiotherapy indications during the COVID-19 pandemic and in future complex logistic settings: the NORMALITY model

Author

Cellini, Francesco, Di Franco, Rossella, Manfrida, Stefania, Borzillo, Valentina, Maranzano, Ernesto, Pergolizzi, Stefano, Morganti, Alessio Giuseppe, Fusco, Vincenzo, Deodato, Francesco, Santarelli, Mario, Arcidiacono, Fabio, Rossi, Romina, Reina, Sara, Merlotti, Anna, Jereczek-Fossa, Barbara Alicja, Tozzi, Angelo, Siepe, Giambattista, Cacciola, Alberto, Russi, Elvio, Gambacorta, Maria Antonietta, Scorsetti, Marta, Ricardi, Umberto, Corvò, Renzo, Donato, Vittorio, Muto, Paolo, and Valentini, Vincenzo

Published
2021
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46. MP53-07 EFFICACY AND SAFETY OF THE COMBINATION OF CISPLATIN PLUS NAB-PACLITAXEL AND NIVOLUMAB WITH RADIOTHERAPY AFTER MAXIMAL TUMOR RESECTION IN NON-METASTATIC MUSCLE INVASIVE BLADDER CANCER (CNN-BC TRIAL)

Author

Racioppi, Marco, primary, Bizzarri, Francesco Pio, additional, Moosavi, Seyed Koosha, additional, Scarciglia, Eros, additional, Russo, Pierluigi, additional, Palermo, Giuseppe, additional, Sparagna, Ileana, additional, Allitto, Anna Rita, additional, Ciccarese, Chiara, additional, Tagliaferri, Luca, additional, Boldrini, Luca, additional, Gambacorta, Maria Antonietta, additional, Valentini, Vincenzo, additional, Tortora, Giampaolo, additional, and Iacovelli, Roberto, additional

Published
2024
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47. Impact of data transfer between treatment planning systems on dosimetric parameters

Author

Meffe, Guenda, primary, Votta, Claudio, additional, Turco, Gabriele, additional, Chillè, Elena, additional, Nardini, Matteo, additional, Romano, Angela, additional, Chiloiro, Giuditta, additional, Panza, Giulia, additional, Galetto, Matteo, additional, Capotosti, Amedeo, additional, Moretti, Roberto, additional, Gambacorta, Maria Antonietta, additional, Boldrini, Luca, additional, Indovina, Luca, additional, and Placidi, Lorenzo, additional

Published
2024
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48. REPeated mAgnetic resonance Image-guided stereotactic body Radiotherapy (MRIg-reSBRT) for oligometastatic patients: REPAIR, a mono-institutional retrospective study

Author

Chiloiro, Giuditta, primary, Panza, Giulia, additional, Boldrini, Luca, additional, Romano, Angela, additional, Placidi, Lorenzo, additional, Nardini, Matteo, additional, Galetto, Matteo, additional, Votta, Claudio, additional, Campitelli, Maura, additional, Cellini, Francesco, additional, Massaccesi, Mariangela, additional, and Gambacorta, Maria Antonietta, additional

Published
2024
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49. A distributed feature selection pipeline for survival analysis using radiomics in non-small cell lung cancer patients

Author

Gottardelli, Benedetta, primary, Gouthamchand, Varsha, additional, Masciocchi, Carlotta, additional, Boldrini, Luca, additional, Martino, Antonella, additional, Mazzarella, Ciro, additional, Massaccesi, Mariangela, additional, Monshouwer, René, additional, Findhammer, Jeroen, additional, Wee, Leonard, additional, Dekker, Andre, additional, Gambacorta, Maria Antonietta, additional, and Damiani, Andrea, additional

Published
2024
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50. Impact of bias field correction on 0.35 T pelvic MR images: evaluation on generative adversarial network-based OARs’ auto-segmentation and visual grading assessment

Author

Vagni, Marica, primary, Tran, Huong Elena, additional, Catucci, Francesco, additional, Chiloiro, Giuditta, additional, D’Aviero, Andrea, additional, Re, Alessia, additional, Romano, Angela, additional, Boldrini, Luca, additional, Kawula, Maria, additional, Lombardo, Elia, additional, Kurz, Christopher, additional, Landry, Guillaume, additional, Belka, Claus, additional, Indovina, Luca, additional, Gambacorta, Maria Antonietta, additional, Cusumano, Davide, additional, and Placidi, Lorenzo, additional

Published
2024
Full Text
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