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Purpose:To report a patient with generalized retinal toxicity to mitogen-activated protein inhibitors.Methods:Retrospective case report.Results:Full-field electroretinogram findings indicate a generalized toxicity to the use of the mitogen-activated protein inhibitor trametinib. There was an improve

BACKGROUND To evaluate the outcomes of a heterogeneous group of patients with chronic ulcer receiving a combination regimen of full-field and fractional erbium-doped yttrium aluminum garnet (erbium: YAG) laser applications. METHODS Enrolled in this study were patients with chronic ulcer who had received at least 2 erbium: YAG laser sessions. Fractional applications followed the initial full-field application for debridement. The therapeutic outcomes were evaluated by serial photographs. The primary outcome measure was the proportion of patients achieving complete re-epithelialization at the first year. RESULTS Forty-three treatment regions from 23 patients between 40 and 90 years (F: M = 11:12; age: 60.3 ± 15.5 years, mean ± SD) were eligible. The ulcers' median duration was 24 months (min-max: 2-240 months). The median number of laser sessions was 5 (min-max: 2-12). Of arterial (n = 13), immunologic (n = 9), venous (n = 8), diabetic (n = 8), and mechanical ulcers (n = 5), the primary outcome measure was achieved in 69%, 77.7%, 75%, 88.8%, and 100% of the groups, respectively. CONCLUSION Full-field erbium: YAG laser applications preserve the vascular architecture and enable delicate debridement. Ongoing maintenance fractional laser sessions promote wound healing. Similar to the previous reports of erbium: YAG laser in venous and diabetic ulcers, arterial ulcers, and ulcers of immunologic origin demonstrated an objective treatment response along with different adjuvant approaches.

This study proposes the use of a high-speed camera as a holographic visual sensor to obtain the dense full-field dynamic parameters of the main beam of a bridge by the field of view through uniaxial rotation photography. Based on the basic principle that the frequency and mode of a structure are inherent characteristics, the mode coordinates obtained from each field of view are unified, normalized, and matched according to the same name pixels to obtain the dense fullfield dynamic parameters of the entire bridge. The frequency and first three order modes of a self-anchored suspension test bridge are collected by the method proposed in this study. The frequency comparison between the accelerometers and dial gauges is within 3%, and the mode shapes are more holographic and more realistic than those obtained by limited measuring points. In addition, the difference in the curvature mode under various damage conditions obtained by limited measurement points is compared with that obtained by the method proposed in this study. Results shows that the dense full-field modal curvature difference can reflect the change in the damage location even in a low order, which means the sensitivity of the change of damage location in low-order modal.

We present a framework for calibration of parameters in elastoplastic constitutive models that is based on the use of automatic differentiation (AD). The model calibration problem is posed as a partial differential equation-constrained optimization problem where a finite element (FE) model of the coupled equilibrium equation and constitutive model evolution equations serves as the constraint. The objective function quantifies the mismatch between the displacement predicted by the FE model and full-field digital image correlation data, and the optimization problem is solved using gradient-based optimization algorithms. Forward and adjoint sensitivities are used to compute the gradient at considerably less cost than its calculation from finite difference approximations. Through the use of AD, we need only to write the constraints in terms of AD objects, where all of the derivatives required for the forward and inverse problems are obtained by appropriately seeding and evaluating these quantities. We present three numerical examples that verify the correctness of the gradient, demonstrate the AD approach's parallel computation capabilities via application to a large-scale FE model, and highlight the formulation's ease of extensibility to other classes of constitutive models.

The adoption of emerging imaging technologies in the medical community is often hampered if they provide a new unfamiliar contrast that requires experience to be interpreted. Here, in order to facilitate such integration, we developed two complementary machine learning approaches, respectively based on feature engineering and on convolutional neural networks (CNN), to perform automatic diagnosis of breast biopsies using dynamic full field optical coherence tomography (D-FF-OCT) microscopy. This new technique provides fast, high resolution images of biopsies with a contrast similar to H&E histology, but without any tissue preparation and alteration. We conducted a pilot study on 51 breast biopsies, and more than 1,000 individual images, and performed standard histology to obtain each biopsy diagnosis. Using our automatic diagnosis algorithms, we obtained an accuracy above 88% at the image level, and above 96% at the biopsy level. Finally, we proposed different strategies to narrow down the spatial scale of the automatic segmentation in order to be able to draw the tumor margins by drawing attention maps with the CNN approach, or by performing high resolution precise annotation of the datasets. Altogether, these results demonstrate the high potential of D-FF-OCT coupled to machine learning to provide a rapid, automatic, and accurate histopathology diagnosis.

Summary An alkaline-surfactant-polymer (ASP) project in the Instow field, Upper Shaunavon Formation in Saskatchewan, Canada, was planned in three phases. The first two multiwell pattern phases are nearing completion. Beginning in 2007, an ASP solution was injected into Phase 1. Phase 1 polymer drive injection began in 2011 after injection of 37% pore volume (PV) ASP solution. Coincident with the polymer drive injection into Phase 1, Phase 2 ASP solution injection began. Phase 2 polymer drive began in 2016 after injection of 55% PV ASP solution. Polymer solution injection for the polymer drives of both phases continues in both phases with Phase 1 and Phase 2 injected volumes being 55 and 42% PV as of August 2019, respectively. Phase 1 and Phase 2 oil cut response to ASP injection showed an increase of approximately four times from 3.2% to a peak of 13.0% for Phase 1 and Phase 2 oil cut increased from 1.8% to a peak of 14.8%, approximately eightfold. Oil rates increased from approximately 3200 m3/m (20 127 bbl/m) at the end of water injection to a peak of 8300 m3/m (52 220 bbl/m) in Phase 1 and from 1230 m3/m (7 736 bbl/m) to 6332 m3/m (39 827 bbl/m) in Phase 2. Phase 1 pattern analysis indicates that the PV of ASP solution injected varied from 13% to 54% PV of ASP. Oil recoveries after the start of ASP solution injection in the different patterns ranged from 2.3% original oil in place (OOIP) up to 21.3% OOIP with lower oil recoveries generally correlating with lower volumes of ASP solution injected. Wells in common to the two phases of the project show increased oil cut and oil rate responses to chemical injection from both Phases 1 and 2. Total oil recovery as of August 2019 is 60% OOIP for Phase 1 and 62% OOIP for Phase 2. Phase 1 economic analysis indicated chemical and operation cost was approximately CAD 26/bbl, resulting in the decision to move forward with Phase 2.

The extraordinary advances in clinical hematology, biology, and oncology in the last decades would not have been possible without discovering how to identify and count the cells circulating in the blood. For centuries, scientists have used slides, counting chambers (hemocytometers), and diluting and staining solutions for this task. Then, automated hemocytometry began. This science, now linked to the daily routine of laboratory hematology, has completed an overwhelming path over a few decades. Our laboratories today operate with versatile multiparameter systems, ranging from complex single-channel instruments to bulky continuous flow machines. In terms of clinical information obtained from a simple routine blood test, the full exploitation of their potential depends on the operators' imagination and courage. A comprehensive review of the scientific publications that have accompanied the development of hemocytometry from the 1950s to today would require entire volumes. More than seven hundred contributions that authors worldwide have published in Clinical and Laboratory Haematology until 2007 and then the International Journal of Laboratory Hematology are summarized. Such journals have represented and hopefully will continue to represent the privileged place of welcome for future scientific research in hemocytometry. Improved technologies, attention to quality, new reagents and electronics, information technology, and scientist talent ensure a more profound and deeper knowledge of cell properties: current laboratory devices measure and count even minor immature or pathological cell subpopulations. Full-field hemocytometry includes the analysis of nonhematic fluids, digital adds to the microscope, and the development of effective point-of-care devices.

Objective To compare lesion conspicuity on synthetic screening mammography (SM) plus digital breast tomosynthesis (DBT) versus full field digital mammography (FFDM) plus DBT. Materials and methods Seven breast imagers each prospectively evaluated 107–228 screening mammograms (FFDM, DBT, and SM; total 1206 examinations) over 12 weeks in sets of 10–50 consecutive examinations. Interpretation sessions alternated as follows: SM + DBT, then FFDM, or FFDM + DBT, then SM. Lesion conspicuity on SM versus FFDM (equal/better versus less) was assessed using proportions with 95% confidence intervals. DBT-only findings were excluded. Results Overall 1082 of 1206 (89.7%) examinations were assessed BI-RADS 1/2, and 124 of 1206 (10.3%) assessed BI-RADS 0. There were 409 evaluated findings, including 134 masses, 119 calcifications, 72 asymmetries, 49 architectural distortion, and 35 focal asymmetries. SM conspicuity compared to FFDM conspicuity for lesions was rated 1) masses: 77 (57%) equal or more conspicuous, 57 (43%) less conspicuous; 2) asymmetries/focal asymmetries: 61 (57%) equal or more conspicuous, and 46 (43%) less conspicuous; 3) architectural distortion: 46 (94%) equal or more conspicuous, 3 (6%) less conspicuous; 4) calcifications: 115 (97%) equal or more conspicuous, 4 (3%) less conspicuous. SM had better conspicuity than FFDM for calcifications and architectural distortion and similar conspicuity for most masses and asymmetries. Conclusion Compared to FFDM, SM has better conspicuity for calcifications and architectural distortion and similar conspicuity for most masses and asymmetries.

SummaryScale inhibitor (SI) squeeze treatments are one of the most common techniques to prevent downhole scale formation. In this paper, we present the optimization of treatment design for multiple wells included in offshore campaigns. Two offshore fields with 8 and 12 production wells in west Africa were considered that are separately treated via yearly squeeze campaigns. The wells included in each campaign are treated in a single trip of the supply vessel. Based on the storage capacity of the vessel, the available volume of SI onboard should be optimally allocated to each of the wells (having different properties and water production rates), so that they are all protected from scaling for 1 year until the next campaign is carried out. A hybrid optimization methodology was applied to optimize the squeeze campaign design.The gradient descent (GD) algorithm was first applied to derive the squeeze “isolifetime proxies” related to each well. Each proxy includes all the possible squeeze designs that result in 365 days of squeeze lifetime in the well. Using these proxies, any combination of wells’ squeeze designs could be nominated as the campaign design, because that would result in treating all wells until the next campaign. The multiobjective particle swarm optimization (MOPSO) technique was implemented to optimize the campaign design by simultaneously minimizing the total SI volume and the total injection time for the whole campaign. Minimizing the total pumping time would consequently minimize the deferred oil volume and the total cost of squeezes in the field.Finally, the Pareto Front was identified for each field, showing the most optimum campaign designs. The Pareto Front was shown to be a valuable tool for the operator to make a trade-off between the size of the vessel and the injection time; that is, to use a bigger vessel to transport more inhibitor to the wells or to use a smaller one but for a longer time to inject more water during the squeeze treatments in the field. A cost analysis was performed to identify the most optimum deployment plan providing the most optimum inhibitor allocation strategy, including the optimum inhibitor volume and the optimum injection time for each campaign.

In the paper, an alignment methodology of finite element and full-field measurement data of planar specimens is presented. The alignment procedure represents an essential part of modern material response characterisation using heterogeneous strain-field specimens. The methodology addresses both the specimen recognition from a measurement’s image and the alignment procedure and is designed to be applied on a single measurement system. This is essential for its practical application because both processes, shape recognition and alignment, must be performed only after the specimen is fully prepared for the digital image correlation (DIC) measurements (white background and black speckles) and placed into a testing machine. The specimen can be observed with a single camera or with a multi-camera system. The robustness of the alignment method is presented on a treatment of a specimen with a metamaterial-like structure and compared with the well-known iterative closest point (ICP) algorithm. The performance of the methodology is also demonstrated on a real DIC application.

This work deals with development analytical formula which may satisfy the original problem of both tangential stress distribution as well as residual stress around the boundary of a hole in plate subjected to a variety of biaxial loading.The developed equation has been employed for computing the tangential stress around a hole for different biaxial loading conditions.Photoelastic coating technique has been used formeasuring the residual stress that remain in plates after performing a hole by piercing, drilling, forming or machining processes.Moreover, based on the strain gauge experimental technique the residual stress has been computed.Comparison of the results indicates the applicability of the developed equation in Computing both Tangential stress distribution as well as residual stress.Moreover, the use of photoelastic coating technique facilitate the experimental tests and provide full field experimental method for determination of stress distribution at points on the surface and in interior of specimens. Thus, the birefringent coating technique has many advantages for measuring residual stresses as compared to strain gauge method.

Comparisons between anomaly and full-field methods have been carried out in weather analysis and forecasting over the last decade. Evidence from these studies has demonstrated the superiority of anomaly to full field in the following four aspects: depiction of weather systems, anomaly forecasts, diagnostic parameters, and model prediction. To promote the use and further discussion of the anomaly approach, this article summarizes those findings. After examining many types of weather events, anomaly weather maps show at least five advantages in weather system depiction: 1) less vagueness in visually connecting the location of an event with its associated meteorological conditions, 2) clearer and more complete depictions of vertical structures of a disturbance, 3) easier observation of time and spatial evolution of an event and its interaction or connection with other weather systems, 4) simplification of conceptual models by unifying different weather systems into one pattern, and 5) extension of model forecast length due to earlier detection of predictors. Anomaly verification is also mentioned. The anomaly forecast is useful for raising one’s awareness of potential societal impact. Combining the anomaly forecast with an ensemble is emphasized, where a societal impact index is discussed. For diagnostic parameters, two examples are given: an anomalous convective instability index for convection, and seven vorticity and divergence related parameters for heavy rain. Both showed positive contributions from the anomalous fields. For model prediction, the anomaly version of the beta-advection model consistently outperformed its full-field version in predicting typhoon tracks with clearer physical explanation. Application of anomaly global models to seasonal forecasts is also reviewed.

In this work the response of soft open-cell polyurethane foams with three different densities, respectively of 85, 63 and 46 kg/m3, were obtained by quasi-static tensile, shear and cyclic compressi...

The dimensional stability of paper products is a well-known problem, affecting multiple engineering applications. The macroscopic response of paper to moisture variations is governed by complex mechanisms originating in the material at all length-scales down to the fiber-level. Therefore, a recently-developed method, based on Global Digital Height Correlation of surface topographies is here exploited to measure the full-field hygro-expansion of single fibers, i. e. a surface strain tensor map over the full field of view is obtained as function of time. From the strain field, the longitudinal and transverse hygro-expansion and principle strains can be calculated. Long- and intermediate-duration dynamic tests are conducted on softwood and hardwood fibers. A large spread in the softwood fiber’s transverse and longitudinal hygro-expansion coefficient ratio was found, while hardwood fibers behave more consistently. Computing the principle strain ratios reduces this spread, as it takes into account the variations of the deformation direction, which is directly affected by the micro-fibril angle (MFA). Furthermore, long-duration tests allow identification of the half-times at which the fibers equilibrate. Finally, the determined major strain angles for all fibers are consistent with the MFA ranges reported in the literature.

The introduction of structural defects in metal-organic frameworks (MOFs), often achieved through the fractional use of defective linkers, is emerging as a means to refine the properties of existing MOFs. These linkers, missing coordination fragments, create unsaturated framework nodes that may alter the properties of the MOF. A property-targeted utilization of this approach demands an understanding of the structure of the defect-engineered MOF. We demonstrate that full-field X-ray absorption near-edge structure computed tomography can help to improve our understanding. This was demonstrated by visualizing the chemical heterogeneity found in defect-engineered HKUST-1 MOF crystals. A non-uniform incorporation and zonation of the defective linker was discovered, leading to the presence of clusters of a second coordination polymer within HKUST-1. The former is suggested to be responsible, in part, for altered MOF properties; thereby, advocating for a spatio-chemically resolved characterization of MOFs.

To investigate the magnitude and time course of pseudorandom ffERG during light adaptation. Ten healthy subjects (26 ± 10.1 years) underwent 20 min of dark adaptation, and then the ffERG was evoked by pseudorandom flash sequences (4 ms per flash, 3 cd.s/m2) driven by m-sequences (210–1 stimulus steps) using Veris Science software and a Ganzfeld dome over a constant field of light adaptation (30 cd/m2). The base period of the m-sequence was 50 ms. Each stimulation sequence lasting 40 s was repeated at 0, 5, 10, 15 and 20 min of light adaptation. Relative amplitude and latency (corrected by values found at 0 min) of the three components (N1, P1, and N2) of first-order (K1) and first slice of the second-order (K2.1) kernel at 5 time points were evaluated. An exponential model was fitted to the mean amplitude and latency data as a function of the light adaptation duration to estimate the time course (τ) of the light adaptation for each component. Repeated one-way ANOVA followed by Tukey post-test was applied to the amplitude and latency data, considering significant values of p

This work is concerned with the micromechanical modeling of porous short fiber-reinforced composites considered as three-phase microstructures: cavities and short fibers embedded in a matrix phase....

Fatigue of filament wound materials was investigated using Digital Image Correlation DIC monitoring every 50th cycle of a high cycle fatigue test of a split disk ring sample. The ring was cut from a filament wound glass fiber reinforced polymer pressure vessel and had a hole. The strain field redistributed over time, lowering and moving strain concentrations. The redistributive behavior was most extensive in areas that later developed local fiber failure, which soon led to catastrophic failure. Microscopy was carried out on partially fatigued material. Damage evolved as matrix cracks and matrix splitting of groups of fibers and complete debonding of single fibers. This occurred at borders of voids and matrix cracks, easing progressive fiber failure. It was concluded that fatigue in filament wound composites has an extensive matrix damage phase before final failure. Fibers could locally withstand strains close to and above the static failure strain for considerable number of cycles if little local strain field redistribution was observed. The used method was able to detect changes in the strain fields that preceded catastrophic failure. It was concluded that DIC combined with the post processing methods presented may serve as a valuable tool for structural integrity monitoring of composite pressure vessels over time.

The current study was intended to use Card Lottery Games Media to improve writing ability. The design of the study is action research. The sample of the study was IX grade students in one selected school. It was found that after implementing Card Lottery Game Media in two cycles, it could be concluded that Card Lottery Games Media was effective to improve the students’ competency in writing report text There were five aspects that should be full field by the students in writing report text, there are; developing ideas (content), organizing ideas, vocabulary, grammar, and mechanics. The students’ improvement could be seen from the mean score of the pre-test (56,25), post-test 1 (74) and post-test 2 (84,25). During the implementation of Card Lottery Games Media, the students were looked serious, enthusiastic, motivated and interested.

Optical coherence tomography, or in short OCT, is a measurement technique established in the early 1990s for the non-invasive imaging of interfaces in the bulk of biological tissues or other samples. A full-field OCT setup is built from a microscope combined with a Michelson interferometer, where the mirror in one arm is replaced by the sample. Using white light, which is temporally partially coherent, interference fringes disclose the presence of an interface whenever the lengths of both interferometer arms are nearly equal. Scanning one arm allows for a volumetric reconstruction of all interfaces inside the sample. While the importance of OCT in medicine is indisputable, it is hard to teach students the basic aspects of such technology as most available setups tend to be rather complex. It is our purpose to present a fully functional full-field OCT setup that is stripped-down to its essential components and to promote its use in an undergraduate lab course. The contribution is complemented by a description of the basic theory necessary to understand the working principle of OCT.

Neurons in the visual system can be spatially organized according to their response properties such as receptive field location and feature selectivity. For example, the visual cortex of many mammalian species contains orientation and direction columns where neurons with similar preferences are clustered. Here, we examine whether such a columnar structure exists in the mouse superior colliculus (SC), a prominent visual center for motion processing. By performing large-scale physiological recording and two-photon calcium imaging in adult male and female mice, we show that direction-selective neurons in the mouse SC are not organized into stereotypical columns as a function of their preferred directions, although clusters of similarly tuned neurons are seen in a minority of mice. Nearby neurons can prefer similar or opposite directions in a largely position-independent manner. This finding holds true regardless of animal state (anesthetized vs awake, running vs stationary), SC depth (most superficial lamina vs deeper in the SC), research technique (calcium imaging vs electrophysiology), and stimulus type (drifting gratings vs moving dots, full field vs small patch). Together, these results challenge recent reports of region-specific organizations in the mouse SC and reveal how motion direction is represented in this important visual center.

The main hurdles in Vacuum Infusion (VI) are the difficulty in achieving complete mold filling and uniform part thickness. This study integrates process monitoring by full field thickness measurements and resin flow modeling that accounts for compaction and permeability characterizations of fabric reinforcements to assess the evolution of part thickness during filling and post-filling stages of VI process. A Structured Light Scanning system is used for full field thickness monitoring in experiments and a Control Volume Finite Element Method solver is implemented to couple resin flow with fabric’s compaction and permeability. Two cases are studied both experimentally and numerically. Evolutions of thickness and pressure validate the developed flow solver, its accuracy in terms of predicting fill times and fill patterns, suitability and limitations of the elastic compaction models for thickness modeling.

A mathematical method is introduced for quantifying full field deformation images of right ventricle (RV) of the heart. These images are acquired from the RV of the heart during open-heart surgery and analysed using digital image correlation (DIC). The high degree of complexity of the deformation of the heart, especially for the patients who require heart surgery emphasises the importance of a method to analyse the visible section of the surface of the RV. This is difficult with conventional heart-monitoring methods, which rely on describing the overall deformation of the area of interest by measuring the deformation between two points only and discarding all other relevant information contained in the area of interest. In this work, we decomposed the full field deformation images of the visible section of RV into shape descriptor vectors and used the Euclidian distance between two shape descriptor vectors obtained from the reference image and the analysed image to quantify the full field deformation by a single number. The Euclidian distance was used to compare the motion and deformation state of the heart at various stages during the operation. We demonstrate that the Euclidian distance is a more robust indicator describing the overall function of the heart than an individual strain value, especially in case of poor-quality images from which the strain is derived. publishedVersion

When retinal activity is increased by exposure to dynamic visual stimuli, blood vessels dilate and the flow of blood within vessels increases to meet the oxygen and glucose demands of the neurons. This relationship is termed ‘neurovascular coupling’ and it is critical for regulating control of the human retinal vasculature. In this study, we used a recently developed technique based on a dual-beam adaptive optics scanning laser ophthalmoscope to measure changes in red blood cell velocities, vessel diameter, and flow in interconnected small parafoveal retinal vessels (t-test showed significant increases in velocity and flow in arterioles and venules. These measurements indicate that the mechanism of neurovascular coupling systematically affects the vascular response in small retinal vessels in order to maintain hemodynamic regulation in the retina when exposed to visual stimulation, in our case flicker. Our findings may provide insight into future investigations on the impairments of neurovascular coupling from vascular diseases such as diabetic mellitus.

Anisotropic shrinkage is a typically feature in wood, which is of critical importance in wood drying. In this study, the shrinkage strains over each growth ring were determined by a full-field strain measurement system during moisture content (MC) loss. Color maps were used to visualize the full-field distribution of displacement and shrinkage strain under different MC conditions. The variation of tangential and radial shrinkage strain from pith to bark, as well as the anisotropic shrinkage in heartwood and sapwood were studied. Both of the displacement and strain values increased as the MC decreased. From pith to bark, the tangential strains were higher at two poles as compared to the center, showing a parabolic distribution below fiber saturation point. While for radial shrinkage strain, a minor difference was observed except for the MC of 10%. An intersection between tangential and radial shrinkage ratio curve was observed at the MC of 28%. Both expansion and shrinkage in tangential direction were larger than radial counterparts, and the transformation from expansion to shrinkage occurred at the MC region of 32–28%. In addition, the shrinkage in heartwood was larger than sapwood, whereas anisotropic shrinkage in sapwood was more pronounced as compared to heartwood.

Background Although traditional intraoperative assessments (ie, frozen sections) may lower reoperation rates in patients with breast cancer, time/tissue limitations and accuracy concerns have discouraged their routine clinical use. Full-field optical coherence tomography (FFOCT) and dynamic cell imaging (DCI) are novel optical imaging techniques offering rapid histologic approximations that are unfettered by requisite handling steps. This study was conducted to determine the feasibility and diagnostic utility of FFOCT and DCI in examining breast and lymph node specimens during breast cancer surgery. Methods FFOCT and DCI were applied to normal and cancerous breast tissue, benign breast lesions, and resected axillary lymph nodes. The tissues were then subjected to conventional processing and staining (hematoxylin-eosin) for purposes of comparison. Results A total of 314 specimens, including 173 breast biopsies (malignant, 132; benign/normal, 41) and 141 resected lymph nodes (tumor-positive, 48; tumor-negative, 93), were obtained from 158 patients during breast surgery for prospective imaging evaluations. In breast cancer diagnosis, the minimum sensitivities (FFOCT, 85.6%; DCI, 88.6%) and specificities of optical imaging (FFOCT, 85.4%; DCI, 95.1%) were high, although they diverged somewhat in nodal assessments (FFOCT sensitivity, 66.7%; FFOCT specificity, 79.6%; DCI sensitivity, 83.3%; DCI specificity, 98.9%). Conclusions These timely and tissue-sparing optical imaging techniques proved highly accurate in diagnosing breast cancer and nodal metastasis. They compare favorably with routine histologic sections and demonstrate their promise in this setting.

Flow modelling challenges in fractured reservoirs have led to the development of many simulation methods. It is often unclear which method should be employed. High-resolution discrete fracture and matrix (DFM) studies on small-scale representative models allow us to identify dominant physical processes influencing flow. We propose a workflow that utilizes DFM studies to characterize subsurface flow dynamics. The improved understanding facilitates the selection of an appropriate method for large-scale simulations. Validation of the workflow was performed via application on a gas reservoir represented using an embedded discrete fracture model, followed by the comparison of results obtained from hybrid and dual-porosity representations against fully explicit simulations. The comparisons ascertain that the high-resolution small-scale DFM studies lead to a more accurate upscaled model for full field simulations. Additionally, we find that hybrid implicit–explicit representations of fractures generally outperform pure continuum-based models.

This study proposed a method capable of reconstructing complex deformations of thin-walled special-section beam structures subjected to highly coupled loading cases, in terms of the combination of tension/compression, biaxial bending, and warping torsion. The complex beam deformation was decoupled, depending on axial strain measurement strategy on beam surface, and leads to reconstructed full-field displacements (deformed shapes) as the linear superposition of deformations subject to individual loading types. Full-filed strain/stress distributions can then be derived based on the reconstructed displacements. Particular efforts were focused on reconstructing beam deformation subject to warping torsion, where both rotations angles and warping displacements across the beam cross-section and along the beam length were identified precisely. As a proof-of-concept validation, the effectiveness of the method was examined using finite element analysis, where the deformed shape of a thin-walled hat-section beam under the coupling between uniaxial bending and warping torsion was reconstructed., Experiments were conducted subsequently to reconstruct deformation of an aluminum hat-section beam using distributed optical fiber sensors for the measurement of axial strains on the beam surface. The reconstructed full-field deformed shapes of the beam were compared with the three-dimensional displacement signals captured using a non-contact digital image correlation system. The effectiveness of the proposed methodology for complex deformation reconstruction is possible to be extended to a variety of thin-walled beam-type structures which are typical in civil and aerospace engineering, showing potential contributions in fields such as on-line structural health monitoring and active structural control.

On the basis of advanced functional structures such as aeronautics and astronautics, it is common to arrange strain measurements at finite points on the structure and then reconstruct the displacem...

Large tensile residual stress is detrimental to the structural integrity of welded structures. As a result, it is very important to understand the residual formation during the welding process. In this paper, a new non-contact welding residual stress measurement technique based on digital image correlation (DIC) is proposed as a way to investigate residual stress formation. To investigate the stress evolution of the welded plate, we conduct a series of experiments by using this new method. High-temperature full-field strain obtained from DIC was computed by incremental theory to acquire stress increment. Stress evolution and residual stress were obtained by superimposing the stress increment. Hole-drilling residual stress measurements for verification were also implemented. The maximum difference, which was 37 MPa between the two methods demonstrated that this new technique was able to characterize the full-field welding residual stress during the welding process.

Background Laser skin resurfacing with erbium-doped yttrium aluminum garnet (Er:YAG) lasers is a newer alternative to CO2 laser treatment, and was developed to reduce common complications. Although Er:YAG lasers have been available for years, safety parameters for efficacious resurfacing with these devices have not previously been available. Objectives The aim of this study was to utilize one practice’s laser treatment settings and outcomes data to identify complication rates for various energies and areas of the face and to offer safe energy/depth parameters for treating each area. Methods A retrospective chart review was performed for full-field confluent laser resurfacing patients treated with a Sciton Contour Tunable Resurfacing Er:YAG laser by the senior author. The data were retroactively analyzed with a time range of 8 years (January 2007-December 2015). Results The overall complication rate for MicroLaserPeels (ablation of 50 µm or less) was 10.1% (20 of 198 treatments) and the rate for deep resurfacing treatments was 26.5% (71 of 268 cases). In MicroLaserPeel treatments the cheek area had the highest complication rate, followed by the forehead, nose, perioral, and eyelid areas, in that order (complication rate range, 0%-9.1%). In deep resurfacing treatments the perioral area had the highest complication rate, 38.6% of 145 cases. This was followed by the lids, cheek, nose, and forehead, in that order (complication rate range, 15.2%-20.9%). There is a correlation between increased depth of ablation and increased rate of complication. Conclusions The study confirmed the efficacy of Er:YAG resurfacing and provides guidance for a safer approach to excellent outcomes. Level of Evidence: 4