104 results on '"Fischell, T."'
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2. CHEMICAL RENAL DENERVATION WITH ALCOHOL – LONG TERM RESULTS FROM THE PEREGRINE POST-MARKET STUDY
- Author
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Persu, A., Renkin, J., Hochul, M., Wojakowski, W., Böhm, M., Mahfoud, F., Schmieder, R., van der Giet, M., de Bucourt, M., Zirlik, A., Neuzil, P., Haratani, N., Parise, H., Fischell, T., Bertog, S., Sievert, K., and Sievert, H.
- Published
- 2018
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3. Edoxaban versus warfarin in patients with atrial fibrillation
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Robert P. Giugliano, Christian T. Ruff, Eugene Braunwald, Sabina A. Murphy, Stephen D. Wiviott, Jonathan L. Halperin, Albert L. Waldo, Michael D. Ezekowitz, Jeffrey I. Weitz, Jind?ich ?pinar, Witold Ruzyllo, Mikhail Ruda, Yukihiro Koretsune, Joshua Betcher, Minggao Shi, Laura T. Grip, Shirali P. Patel, Indravadan Patel, James J. Hanyok, Michele Mercuri, Elliott M. Antman, Braunwald E, Antman EM, Giugliano RP, Ruff CT, Morin SE, Hoffman EB, Murphy SA, Deenadayalu N, Grip L, Mercuri M, Lanz H, Patel I, Curt V, Duggal A, Hanyok J, Davé J, Morgan D, Choi Y, Shi M, Jin J, Xie J, Crerand W, Kappelhof J, Maxwell W, Skinner M, Patel S, Betcher J, Selicato G, Otto C. Jr, Reissner C, Smith K, Ostroske J, Ron A, Giugliano R, Connolly S, Camm J, Ezekowitz M, Halperin J, Waldo A, Paolasso E, Aylward P, Heidbuchel H, Nicolau JC, Goudev A, Roy D, Weitz J, Corbalán R, Yang Y, Botero R, Bergovec M, Ŝpinar J, Grande P, Hassager C, Voitk J, Huikuri H, Nieminen M, Blanc JJ, LeHeuzey JY, Mitrovic V, Alexopoulos D, Sotomora G, Kiss R, SomaRaju B, Lewis B, Merlini P, Metra M, Koretsune Y, Yamashita T, García Castillo A, Ophuis T, White H, Atar D, Horna M, Babilonia N, Ruzyllo W, Morais J, Dorobantu M, Ruda M, Ostojic M, Duris T, Dalby A, Chung N, Zamorano JL, Juul Möller S, Moccetti T, Chen SA, Sritara P, Oto A, Parkhomenko A, Senior R, Verheugt F, Skene A, Anderson J, Bauer K, Easton JD, Goto S, Wiviott S, Lowe C, Awtry E, Berger CJ, Croce K, Desai A, Gelfand E, Goessling W, Greenberger NJ, Ho C, Leeman DE, Link MS, Norden AD, Pande A, Rost N, Ruberg F, Silverman S, Singhal A, Vita JA, Vogelmann O, Gonzalez C, Ahuad Guerrero R, Rodriguez M, Albisu J, Rosales E, Allall O, Reguero M, Alvarez C, Garcia M, Ameriso S, Ameriso P, Amuchastegui M, Caceres M, Beloscar J, Petrucci J, Berli M, Budassi N, Valle M, Bustamante Labarta G, Saravia M, Caccavo A, Fracaro V, Cartasegna L, Novas V, Caruso O, Zarandon RS, Colombo H, Morandini M, Cuello J, Rosell M, Cuneo C, Bocanera M, D'Amico A, Cendali G, Dran R, Moreno V, Estol C, Davolos M, Facello A, Facello M, Falu E, Iriarte M, Femenia F, Arrieta M, Fuselli J, Zanotti A, Gant Lopez J, Meiller F, Garcia Duran R, Perlo D, Garrido M, Ceirano C, Giacomi G, Eden M, Giannaula R, Huerta M, Goicoechea R, von Wulffen M, Hominal M, Bianchini M, Jure H, Jure D, Kevorkian R, Monaco F, Lanternier G, Belcuore M, Liniado G, Iglesias M, Litvak B, Nigro A, Llanos J, Vignau S, Lorente C, Shatsky K, Lotti J, Raimondi G, Mackinnon I, Carne M, Manuale O, Calderon M, Marino J, Funes I, Muntaner J, Gandur H, Nul D, Verdini E, Piskorz D, Tommasi A, Povedano G, Casares E, Pozzer D, Fernandez E, Prado A, Venturini C, Ramos H, Navarrete S, Alvarez M, Sanchez A, Bowen L, Sanjurjo M, Codutti O, Saravia Toledo S, Formoso I, Schmidberg J, Goloboulicz A, Schygiel P, Buzzetti C, Severino P, Morara P, Sosa Liprandi M, Teves M, Vico M, Morell Y, Anderson C, Paraskevaidis T, Arstall M, Hoffmann B, Colquhoun D, Price Smith S, Crimmins D, Slattery A, Dart A, Kay S, Davis S, Silver G, Flecknoe Brown S, Roberts J, Gates P, Jones S, Lehman R, Morrison H, McKeirnan M, Li J, Paul V, Batta C, Purnell P, Perrett L, Szto G, O'Shea V, Capiau L, Banaeian F, De Bleecker J, de Koning K, De Tollenaere M, De Bruyne L, Desfontaines P, Tincani G, Meeusen K, Herzet J, Malmendier D, Mairesse G, Raepers M, Parqué J, Clinckemaille N, Scavée C, Huyberechts D, Stockman D, Jacobs C, Vandekerckhove Y, Derycker K, Vanwelden J, van Welden J, Vervoort G, Mestdagh I, Vrolix M, Beerts C, Wollaert B, Denie D, Amato Vincenzo de Paola A, Coutinho E, Andrade Lotufo P, de Melo RF, Atie J, Motta C, Augusto Alves da Costa F, Ferraz RF, Bertolim Precoma D, Sehnem E, Botelho R, Cunha S, Brondani R, Fleck N, Chaves Junior H, Silva J, Costantini C, Barroso D, De Patta M, Pereira V, Duda N, Laimer R, Dutra O, Morgado S, Faustino Saporito W, Seroqui M, Ferreira L, Araújo E, Finimundi H, Daitz C, Gagliardi R, Pereira G, Gomes M, Gomes A, Guimarães A, Ninho L, Jaeger C, Pereira L, Jorge J, Cury C, Kaiser S, Almeida A, Kalil C, Radaelli G, Kunz Sebba Barroso de Souza W, Morales K, Leaes P, Luiz RO, Pimenta Almeida J, Gozalo A, Reis G, Avellar K, Reis Katz Weiand L, Leipelt J, Rocha J, Barros R, Rodrigues L, Rocha MR, Rodrigues A, Rodrigues D, Rossi dos Santos F, Pagnan LG, Sampaio R, do Val R, Saraiva J, Vicente C, Simoes M, Carraro A, Sobral Filho D, Lustosa E, Villas Boas F, Almeida M, Zimmermann S, Zimmermann EB, Chompalova B, Parishev G, Denchev S, Milcheva N, Donova T, Gergova V, Georgiev B, Kostova E, Kinova E, Hergeldjieva V, Kamenova P, Manolova A, Vasilev I, Mihov A, Miteva B, Mincheva V, Stoyanovski V, Nikolov F, Vasilev D, Pencheva G, Kostov K, Petranov S, Milusheva T, Popov A, Staneva A, Momchilova Lozeva D, Todorov G, Nyagina M, Tumbev H, Tumbeva D, Tzekova M, Kitova M, Manoylov E, Archibald J, Antle S, Bhargava R, Stafford C, Bose S, Hundseth M, Cha J, Otis J, Chehayeb R, Lepage C, Chilvers M, Vansickle L, Cleveland D, Valley S, Constance C, Gauthier M, Costi P, Masson C, Coutu B, Denis I, du Preez M, Kubanska A, Dufresne M, Krider J, Eikelboom J, Zondag M, Fortin C, Viau C, Green M, Houbraken D, Hatheway R, Mabee J, Heath J, Scott L, Ho K, Ho V, Hoag G, Standring R, Huynh T, Perkins L, Kouz S, Roy M, Labonte R, Dewar C, Lainesse A, St Germain L, Lam S, Lam H, Lichtenstein T, Roberts P, Luton R, Douglas S, Ma P, Seib M, MacCallum C, Matthews J, Malette P, Vaillancourt T, Maranda C, Studenikow E, Mawji A, Morely A, Morrison D, Roth M, Mucha M, Najarali A, Lamoureux U, Nicholson R, O'Hara G, Banville P, O'Mahony W, Bolton R, Parkash R, Carroll L, Pesant Y, Sardin V, Polasek P, Turri L, Qureshi A, Nethercott C, Ricci J, Bozek B, Rupka D, Marchand C, Shu D, Silverio G, St Hilaire R, Morissette A, Sussman J, Kailey P, Syan G, Bobbie C, Talajic M, David D, Talbot P, Tremblay M, Teitelbaum I, Teitelbaum J, Velthuysen G, Giesbrecht L, Wahby R, Morley A, Wharton S, Caterini T, Woodford T, Balboa W, Matus LR, Bugueño C, Mondaca PM, Cobos J, Obreque C, Corbalan R, Parada A, Florenzano F, Diaz PA, Lopetegui M, Rebolledo C, Manriquez L, Silva LM, Martinez D, Llamas RR, Opazo M, Pérez MC, Pincetti C, Carrasco GT, Potthoff S, Staub JZ, Campisto Y, Stockins B, Lara CL, Yovaniniz P, Azua MG, Bai F, Xu GL, Chen JZ, Xie XD, Chen XP, Zhang X, Dong YG, Feng C, Fu GS, Zhang P, Hong K, You ZG, Hong L, Qiu Y, Jiang XJ, Qu Z, Li L, Liu H, Li TF, Kong YQ, Li WM, Liu B, Li ZQ, Liu Y, Liao DN, Gu XJ, Liu L, Lu ZH, Ma SM, Yang ZY, Wang DM, Qi SY, Wang GP, Shi XJ, Wei M, Huang D, Wu SL, Li YE, Xu JH, Gu JY, Xu YM, Liang YZ, Yang K, Li AY, Yang YJ, Zheng X, Zheng Y, Gao M, Yin YH, Xu YP, Yu B, Li LL, Yuan ZY, Qiang H, Zhang HQ, Lin YN, Zhang Z, Kang H, Zhao RP, Han RJ, Zhao XL, Wang JQ, Zheng ZQ, Li BG, Zhou SX, Zhang YL, Accini J, Accini M, Cano N, Pineda LL, Delgado Restrepo J, Arroyave C, Fernández Ruiz R, Diaz IA, Hernandez H, Delgado P, Jaramillo Muñoz C, Builes A, Manzur F, Rodriguez ER, Moncada Corredor M, Giraldo DL, Orozco Linares L, Fonseca J, Quintero A, Gonzales C, Sanchez Vallejo G, Mejia IP, Bagatin J, Carevic V, Car S, Jeric M, Ciglenecki N, Tusek S, Ferri Certic J, Romic I, Francetic I, Ausperger KM, Jelic V, Jurinjak SJ, Knezevic A, Buksa B, Samardzic P, Lukenda KC, Steiner R, Kirner D, Sutalo K, Bakliza Z, Vrazic H, Lucijanic T, Bar M, Brodova P, Berka L, Kunkelova V, Brtko M, Burianova H, Cermak O, Elbl L, Ferkl R, Florian J, Francek L, Golan L, Gregor P, Honkova M, Hubac J, Jandik J, Jarkovsky P, Jelinek Z, Jerabek O, Jirmar R, Kobza R, Kochrt M, Kostkova G, Kosek Z, Kovar P, Kuchar R, Kvasnicka J, Ludka O, Machova V, Krocova E, Melichar M, Nechanicky R, Olsr J, Peterka K, Petrova I, Havlova I, Pisova J, Podrazil P, Jirsova E, Reichert P, Slaby J, Spacek R, Spinar J, Labrova R, Vodnansky P, Samkova D, Zidkova E, Dodt K, Christensen H, Christensen L, Loof A, Ibsen H, Madsen H, Iversen H, Veng Olsen T, Nielsen H, Olsen R, Overgaard K, Petrovic V, Raymond I, Raae D, Sand N, Svenningsen A, Torp Pedersen C, Jakobsen U, Wiggers H, Serup Hansen K, Kaik J, Stern A, Kolk R, Laane E, Rivis L, Paumets M, Laheäär M, Rosenthal A, Rajasalu R, Vahula V, Ratnik E, Kaarleenkaski S, Hussi E, Valpas S, Jäkälä P, Lappalainen T, Mäenpää A, Viitaniemi J, Nyman K, Sankari T, Rasi H, Salminen O, Virtanen V, Nappila H, Le Heuzey J, Agraou B, El Jarroudi F, Amarenco P, Boursin P, Babuty D, Boyer M, Belhassane A, Berbari H, Blanc J, Dias P, Coisne D, Berger N, Decoulx E, El Jarroudi M, Dinanian S, Arfaoui M, Hermida J, Deruche E, Kacet S, Corbut S, Poulard J, Leparree S, Roudaut R, Duprat C, Al Zoebi A, Wurow A, Bernhardt P, Dichristin U, Berrouschot J, Vierbeck S, Beyer Westendorf J, Sehr B, Bouzo M, Schnelzer P, Braun R, Ladenburger K, Buhr M, Weihrauch D, Contzen C, Kara M, Daut W, Ayasse D, Degtyareva E, Kranz P, Drescher T, Herfurth B, Faghih M, Forck Boedeker K, Schneider K, Fuchs R, Manuela W, Grigat C, Otto A, Hartmann A, Peitz M, Heuer H, Dieckheuer U, Hoffmann U, Dorn S, Hoffmann S, Schuppe M, Horacek T, Fink P, Junggeburth J, Schmid S, Jungmair W, Schoen B, Kleinecke Pohl U, Meusel P, Koenig H, Bauch F, Lohrbaecher Kozak I, Grosse B, Lueders S, Venneklaas U, Luttermann M, Wulf M, Maus O, Hoefer K, Meissner G, Braemer U, Meyer Pannwitt U, Frahm E, Vogt S, Muegge A, Barbera S, Mueller Glamann M, Raddatz K, Piechatzek R, Lewinsky D, Pohl W, Proskynitopoulos N, Kuhlmann M, Rack K, Pilipenko H, Rinke A, Kühlenborg A, Schaefer A, Szymanowski N, Schellong S, Frommhold R, Schenkenberger I, Finsterbusch T, Dreykluft K, Schiewe C, Schmidt A, Schmidt M, Schreckenberg A, Hellmers J, Seibert H, Gold G, Sohn H, Baylacher M, Spitzer S, Bonin K, Stoehring R, Taggeselle J, Zarpentin C, Veltkamp R, Ludwig I, Voehringer, Buchholz M, Weyland K, Winkelmann B, Buelow Johansen B, Wolde C, Winter K, Mavronasiou E, Bourlios P, Tziortziotis A, Karamitsos C, Exarchou E, Kifnidis K, Daskalaki A, Moschos N, Dimitra K, Olympios C, Kartsagkoulis E, Pyrgakis V, Korantanis K, Ayau Milla O, Ramirez Vde L, Guzman Melgar I, Jimenez T, Ovando Lavagnino A, Guevara S, Rodas Estrada M, Sanchez M, Pozuelos JM, Sanchez Samayoa C, Guerra L, Velasquez Camas L, Almaraz SP, Dioszeghy P, Muskoczki E, Edes I, Szatmari J, Fiok J, Varga A, Kanakaridisz N, Kosztyu M, Kis E, Feil JF, Jakal A, Koczka M, Kovacs I, Baranyai M, Kovacs Z, Lupkovics G, Karakai HH, Matoltsy A, Kiss T, Medvegy M, Kiss K, Merkely B, Kolumban E, Nagy A, Palinkas A, Toth SR, Sayour A, Bognar A, Simor T, Ruzsa D, Sipos T, Szakal I, Tomcsanyi J, Marosi A, Vertes A, Kincses M, Malhan S, Abdullakutty J, Agarwal D, Ranka R, Arneja J, Memon A, Arora V, Shree R, Avvaru G, Shaikh A, Babu P, Rao B, Babu R, Reddy J, Banker D, Sheth T, Benjarge P, Surushe S, Bharani A, Solanki R, Bhargava V, Rathi A, Biniwale A, Bhuti M, Calambur N, Somaraju B, Karnwal N, Chopda M, Mali N, Goyal N, Saini A, Gupta J, Singh P, Hadan S, Savanth P, Hardas S, Thakor G, Hiremath J, Ghume A, Jain R, Pahuja M, Joseph S, Oommen D, Joseph J, Thomas R, Joshi H, Iby, Kale V, Raut N, Kandekar B, Kandekar S, Kishore R, Krishnan H, Kotiwale V, Kulkarni R, Deokar M, Kulkarni G, Lawande A, Kumar P, Karpuram M, Kumar A, Francis J, Kumbla M, Anthony A, Lavhe P, Kale M, Mardikar H, Bhaskarwar P, Mathur A, Sharma P, Menon J, Francis V, Namjoshi D, Shelke S, Narendra J, Natarajan S, Oomaan A, Gurusamy P, Angel J, Purayil MP, Shams S, Pandurangi U, Sababathi R, Parekh P, Jasani B, Patki N, Babbar A, Pinto B, Kharalkar H, Premchand R, Jambula H, Rao M, Vuriya A, Ravi Shankar A, Reddy R, Bekal S, Barai A, Saha D, Gadepalli R, Sant H, Jadhav D, Sarna M, Arora T, Sawhney J, Singh R, Sethi K, Bansal N, Sethia A, Sethia S, Shetty G, Sudheer R, Singh G, Gupta R, Srinivas A, Thankaraj L, Varma S, Kaur A, Vinod MV, Thakur B, Zanwar I, Dharmarao A, Atar S, Lasri E, Dicker D, Marcoviciu D, Elias M, Ron GA, Francis A, Ghantous R, Goldhaber A, Goldhaber M, Gottlieb S, Rouwaida S, Grossman E, Dagan T, Hasin Y, Roshrosh M, Hayek T, Majdoub A, Klainman E, Genin I, Lahav M, Gilat T, Ben Ari M, Lishner M, Karny M, Ouzan E, Givoni H, Rozenman Y, Logvinenko S, Schiff E, Sterlin J, Shochat M, Aloni I, Swissa M, Belatsky V, Tsalihin D, Kisos D, Zeltser D, Platner N, Berni A, Giovannelli F, Boriani G, Cervi E, Comi G, Peruzzotti L, Cuccia C, Forgione C, De Caterina R, De Pace D, De Servi S, Mariani M, Di Lenarda A, Mazzone C, Di Pasquale G, Di Niro M, Fattore L, Bosco B, Grassia V, Murena E, Laffi, Gaggioli G, Lo Pinto G, Raggi F, Marino P, Francalacci G, Babbolin M, Bulgari M, Penco M, Lioy E, Marciano C, Pirelli S, Paradiso G, Piseddu G, Fenu L, Raisaro A, Granzow K, Rasura M, Cannoni S, Severi S, Breschi M, Toschi V, Gagliano M, Zacà V, Furiozzi F, Hirahara T, Akihisa U, Masaki W, Ajioka M, Matsushita C, Anzai T, Mino K, Arakawa S, Tsukimine A, Endo H, Fujiwara M, Fujii K, Kozeni S, Fujii E, Kotera M, Fujimoto S, Omae K, Fujimoto K, Ichishita Y, Fujita T, Ito Y, Fukamizu S, Harada J, Fukuda N, Fujimoto C, Funazaki T, Yamaguchi A, Furukawa Y, Kamitake C, Hagiwara N, Naganuma M, Hara S, Kumagai S, Harada K, Fuki Y, Haruna T, Nakahara Y, Hashimoto Y, Shimazu Y, Hiasa Y, Oga Y, Higashikata T, Nakagawa Y, Hirayama A, Kawaguchi A, Iesaka Y, Miyamoto C, Iijima T, Higuchi K, Ino H, Noguchi H, Inomata T, Nakamura K, Ishibashi Y, Nozaki T, Ishii Y, Tomita H, Ishimaru S, Ise M, Itamoto K, Ito T, Onishi M, Iwade K, Sakuma Y, Iwasaki T, Nagatome H, Kakinoki S, Adachi C, Kamakura S, Nakahara F, Kamijo M, Iida S, Kamiyama K, Fujii R, Kato K, Ishida A, Kazatani Y, Ichikawa Y, Kitazawa H, Igarashi C, Kobayashi Y, Kikuchi R, Kohno M, Tamura S, Yumoto I, Kurabayashi M, Koya E, Masuyama T, Kaneno Y, Matsuda K, Ebina E, Meno H, Satake M, Mita T, Takeda M, Miyamoto N, Kimizu T, Miyauchi Y, Sakamoto S, Munemasa M, Murata J, Nagai Y, Sakata Y, Naito S, Oyama H, Nishi Y, Nagase T, Ochiai J, Junko H, Ogawa T, Sugeno M, Oguro H, Tanabe M, Okada K, Moriyama Y, Okajima K, Nakashima M, Okazaki O, Wada H, Okishige K, Kitani S, Okumura K, Narita Y, Onaka H, Moriyama H, Ozaki Y, Tanikawa I, Sakagami S, Nakano A, Sakuragi S, Hayashi N, Sakurai S, Ooki H, Sasaki T, Oosawa N, Satoh A, Fujimoto E, Seino Y, Narumi M, Shirai T, Shigenari M, Shoji Y, Ueda J, Sugi K, Miyazaki E, Sumii K, Asakura H, Takagi M, Mohri S, Takahashi W, Yoshida K, Takahashi A, Kishi N, Takahashi T, Sakurai Y, Takeda K, Yahata A, Takenaka T, Yamagishi K, Takeuchi S, Watanabe E, Tanaka K, Uchida M, Tanouchi J, Nishiya Y, Tsuboi H, Tsuboi N, Terakura K, Uematsu M, Yasumoto S, Ueyama Y, Usuda K, Sakai Y, Yagi M, Sato A, Yagi H, Kuroda T, Yamabe H, Sakamoto Y, Yamada T, Yamano R, Yamagishi T, Sasaki S, Yamamoto Y, Yamashina A, Takiguchi M, Yonehara T, Yoshino H, Nomura H, Yoshioka K, Fujiwara Y, Bayram Llamas E, Hurtado A, Calvo Vargas C, Limon MC, Cardona Muñoz E, Hernandez S, Carrillo J, Delgadillo T, Cásares Ramirez M, Valles JF, Garcia N, Colin MA, Garcia Castillo A, Jaramillo A, Leiva Pons J, de la Mora S, Llamas Esperón G, Grajales A, Mendez Machado G, Avila H, Ruiz LN, Magallanes G, Sánchez Díaz C, Ortiz A, Sánchez RV, Velazquez EM, Alhakim M, van Welsen I, Bruning T, Jones A, Buiks C, de Groot J, Radder I, de Vos R, Hazeleger R, Daniels R, Kietselaer B, Muijs L, Mannaerts H, Kooiman E, Mevissen H, van der Heijden D, Hofmeyer H, Anscombe R, O'Meeghan T, Kjentjes M, Benatar J, Borthwick L, Doughty R, Copley M, Fisher R, Monkley R, Green B, Scott D, Hamer A, Tomlinson J, Hart H, Turner A, Cammell R, Troughton R, Skelton L, Young C, Kennett K, Claussen H, Hofsøy K, Melbue R, Sandvik J, Thunhaug H, Tveit A, Enger S, Bustamante G, Guillen MT, Cabrera J, Mendoza RE, Chavez C, Luna C, Lema J, Carrion A, Llerena N, Bedregal SA, Medina Palomino F, Rodriguez J, Minchola J, Bautista C, Negron Miguel S, Armas BH, Rodriguez A, Romero N, Torres P, Rodriguez KF, Yanac Chavez P, Delgado S, Sambaz CM, Barcinas R, Zapanta M, Coching R, Vallenas M, Matiga G, Enad C, Rogelio G, Joaquin F, Roxas A. 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Pazier P, Riofrio K, Braun D, Robinson J, Cherrico M, Roehll W, Hollihan P, Rosado, Barnhorst M, Rosado J, Bamhorst M, Rosen R, Martin C, Ross S, Freeman R, Ruoff G, Nelson T, Sacco J, Ball E, Samal A, Schomburg J, Sandberg J, Lafave J, Savin V, Clifton R, Schaefer S, Fekete A, Schneider R, Schneider W, Schulman D, Mercer S, Seals A, Ullig T, Holt A, Seide H, Mather N, Shah G, Witt P, Shalaby A, Seese M, Shanes J, Fleets J, Shaoulian E, Hren A, Sheikh K, Hengerer T, Shih H, Browning J, Shoukfeh M, Stephenson L, Siler T, Champagne M, Simpson P, Meyer R, Singh N, Turner K, Singh V, Nelson M, Skierka R, Hughes B, Keene R, Smith R, Hodnett P, Spangenthal S, Thomason L, Sperling M, Vasquez E, Spivack E, McCartney P, Staniloae C, Liu M, Steljes A, Cox C, Struble R, Vittitow T, Suresh D, Frost J, Swerchowsky V, Freemyer D, Szulawski I, Herwehe S, Tahirkheli N, Springer K, Takata T, Bruton T, Talano J, Leo L, Tami L, Corchado D, Tatarko M, Swauger M, Tawney K, Dastoli K, Teague S, Young K, Tee H, Mitchell T, Teixeira J, Southam D, Torres M, Tucker P, Salas L, Updegrove J, Hanna K, Val Mejias J, Harrelson KG, Vemireddy D, Cardoza T, Verma S, Parsons T, Vicari R, Warren K, Vijay N, Washam M, Vossler M, Kilcup S, Walsh R, Renaud K, Ward S, Locklear T, Waxman F, Sanchez G, Weiss R, St Laurent B, Westcott J, Williams D, Gibson C, Williams R, Dowling C, Willis J, VonGerichten S, Wood K, Capasso Gulve E, Worley S, Pointer S, Yarows S, Sheehan T, Yasin M, Yi J, Dongas B, Yousuf K, Zakhary B, Curtis S, Zeig S, Mason T, Zellner C, Harden M, Roper E, Waseem M, Grammer M., PERRONE FILARDI, PASQUALE, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai [New York] (MSSM), University Hospitals Case Medical Center (CLEVELAND - UHCMC), University Hospitals Case Medical Center, Jefferson Medical College (JMC), Thomas Jefferson University Hospitals, Thrombosis and Atherosclerosis Research Institute (TARI), McMaster University [Hamilton, Ontario], University Hospital Brno, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Cardiology Research Center (MOSCOU - CRC), Cardiology Research Center, National Hopital Organization (OSAKA - NHO), Osaka National Hospital, Université de Brest (UBO), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Graduate School, Endocrinology, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Nursing, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, Giugliano, Rp, Ruff, Ct, Braunwald, E, Murphy, Sa, Wiviott, Sd, Halperin, Jl, Waldo, Al, Ezekowitz, Md, Weitz, Ji, Špinar, J, Ruzyllo, W, Ruda, M, Koretsune, Y, Betcher, J, Shi, M, Grip, Lt, Patel, Sp, Patel, I, Hanyok, Jj, Mercuri, M, Antman, Em, Comi, Giancarlo, ENGAGE AF TIMI 48, Investigators, Robert P., Giugliano, Christian T., Ruff, Eugene, Braunwald, Sabina A., Murphy, Stephen D., Wiviott, Jonathan L., Halperin, Albert L., Waldo, Michael D., Ezekowitz, Jeffrey I., Weitz, Jind?ich, ?pinar, Witold, Ruzyllo, Mikhail, Ruda, Yukihiro, Koretsune, Joshua, Betcher, Minggao, Shi, Laura T., Grip, Shirali P., Patel, Indravadan, Patel, James J., Hanyok, Michele, Mercuri, Elliott M., Antman, Morin, Se, Hoffman, Eb, Deenadayalu, N, Grip, L, Lanz, H, Curt, V, Duggal, A, Hanyok, J, Davé, J, Morgan, D, Choi, Y, Jin, J, Xie, J, Crerand, W, Kappelhof, J, Maxwell, W, Skinner, M, Patel, S, Selicato, G, Otto C., Jr, Reissner, C, Smith, K, Ostroske, J, Ron, A, Giugliano, R, Connolly, S, Camm, J, Ezekowitz, M, Halperin, J, Waldo, A, Paolasso, E, Aylward, P, Heidbuchel, H, Nicolau, Jc, Goudev, A, Roy, D, Weitz, J, Corbalán, R, Yang, Y, Botero, R, Bergovec, M, Ŝpinar, J, Grande, P, Hassager, C, Voitk, J, Huikuri, H, Nieminen, M, Blanc, Jj, Leheuzey, Jy, Mitrovic, V, Alexopoulos, D, Sotomora, G, Kiss, R, Somaraju, B, Lewis, B, Merlini, P, Metra, M, Yamashita, T, García 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Grammer, M.
- Subjects
Male ,Pyridines ,[SDV]Life Sciences [q-bio] ,Embolism ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Atrial Fibrillation ,MESH: Double-Blind Method ,030212 general & internal medicine ,MESH: Warfarin ,Stroke ,MESH: Aged ,MESH: Middle Aged ,Cardiovascular diseases [NCEBP 14] ,Hazard ratio ,General Medicine ,MESH: Follow-Up Studies ,Middle Aged ,3. Good health ,MESH: Atrial Fibrillation ,Cardiovascular Diseases ,Anesthesia ,Cardiology ,Female ,Adult ,Aged ,Anticoagulants ,Double-Blind Method ,Follow-Up Studies ,Hemorrhage ,Humans ,Thiazoles ,Warfarin ,MESH: Hemorrhage ,Andexanet alfa ,medicine.drug ,medicine.medical_specialty ,MESH: Enoxaparin ,MESH: Anticoagulants ,MESH: Stroke ,Dabigatran ,03 medical and health sciences ,Internal medicine ,medicine ,MESH: Kaplan-Meier Estimate ,Rivaroxaban ,MESH: Humans ,business.industry ,MESH: Cardiovascular Diseases ,MESH: Adult ,medicine.disease ,Confidence interval ,MESH: Male ,chemistry ,business ,MESH: Female ,MESH: Embolism - Abstract
Contains fulltext : 125374.pdf (Publisher’s version ) (Open Access) BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P
- Published
- 2013
4. Impact of Spontaneous Extracranial Bleeding Events on Health State Utility in Patients with Atrial Fibrillation: Results from the ENGAGE AF‐TIMI 48 Trial
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Senior, R., Paul, J., McKnight, T., Formoso, I., Saravia Toledo, S., Codutti, O., Sanjurjo, M., Bowen, L., Sanchez, A., Alvarez, M., Rodriguez, M., Navarrete, S., Ramos, H., Venturini, C., Prado, A., Fernandez, E., Pozzer, D., Casares, E., Povedano, G., Tommasi, A., Piskorz, D., Verdini, E., Nul, D., Gandur, H., Muntaner, J., Funes, I., Marino, J., Calderon, M., Manuale, O., Carne, M., Mackinnon, I., Raimondi, G., Lotti, J., Shatsky, K., Rodkey, K., Lorente, C., Vignau, S., Llanos, J., Nigro, A., Litvak, B., Iglesias, M., Liniado, G., Belcuore, M., Lanternier, G., Monaco, F., Kevorkian, R., Jure, D., Jure, H., Bianchini, M., Avery, D., Hominal, M., von Wulffen, M., McKenzie, M., Miranda, J., Wright, L., Pye, M., Flint, L., Newby, D., Andrews, A., Goicoechea, R., Huerta, M., Giannaula, R., Eden, M., Giacomi, G., Ceirano, C., Garrido, M., Perlo, D., Garcia Duran, R., Meiller, F., Gant Lopez, J., Zanotti, A., Fuselli, J., Arrieta, M., Femenia, F., Falu, E., Facello, M., Facello, A., Murdoch, D., Helliwell, L., More, R., Isted, C., Maxwell, T., Jones, D., Marazzi, P., McGhee, C., MacLeod, M., Ebano, P., MacCallum, P., Davolos, M., Estol, C., Moreno, V., Dran, R., Cendali, G., D'Amico, A., Bocanera, M., Cuneo, C., Rosell, M., Cuello, J., Morandini, M., Colombo, H., Brown, R., Saa Zarandon, R., Caruso, O., Novas, V., Cartasegna, L., Fracaro, V., Caccavo, A., Saravia, M., Bustamante Labarta, G., Valle, M., Budassi, N., Lip, G., Finlayson, M., Linker, N., McGuire, K., Atkinson, C., Lindsay, S., Ramasamy, V., Lie, F., Dickinson, D., Douglas, H., D'Costa, D., Wilmott, R., Cohen, A., Duff, J., Choy, A., Davies, D., Chapman, O., Dougal, K., Camm, J., Price, R., Blagden, M., Schwarz, L., McGarvey, J., Stubbs, L., McCartney, M., Hicks, T., Massin, E., Bedenko, E., Marenberg, M., Rabadi-Marar, D., Dunn, S., Beeton, I., Smith, S., Aggarwal, R., Marar, I., Hernandez, S., Berli, M., Petrucci, J., Beloscar, J., Caceres, M., Amuchastegui, M., Ameriso, P., Ameriso, S., Garcia, M., Alvarez, C., Reguero, M., Allall, O., Rosales, E., Albisu, J., Ahuad Guerrero, R., Gonzalez, C., Vogelmann, O., Magnuson, Elizabeth A., Cohen, David J., Giugliano, Robert P., Mandviwala, M., Casas, R., Makam, S., Lisiecki, B., Mainigi, S., Doctor, A., Magee, A., Bush, D., Macomber, J., Edelstein, J., Lurie, M., Wright, H., Lui, H., Ault, S., Looby, R., Davids, M., Lone, B., Shah, D., Lomnitz, D., Wofford, E., Littlefield, R., Murphy, R., Ling, L., Miller, D., Lillestol, M., Bonds, C., Lewis, D., Hartley, L., Lesser, M., Smith, D., Lentz, M., Royse, H., Ledbetter, L., Faucett, S., Langevin, E., Simmons, T., Lang, J., Ferguson, D., Landau, C., Coyle, G. 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D., Herrod, J., Batchell, K., Hermany, P., Harkins, V., Henry, S., Millard, D., Henderson, D., Dandekar, U., Heiman, M., Krater, C., Hearne, S., Bobade, M., Harris, J., Cavanna, L., Han, M., Bentivenga, L., Hamroff, G., Morelli, L., Hack, T., McLean, R., Gvora, T., Felsman, D., Guthrie, R., Foster, B., Guerrero, Guerrero, Fisher, M., Guarnieri, T., Gabela, W., Guarino, J., Mabe, K., Grove, D., Davis, A., Grossman, C., Goodman, V., Griffin, J., Aull, L., Griffin, S., Bonora, M., Graham, S., Rafala, E., Gowda, S., Goldstein, M., Latteri, J., Goldscher, D., Ewing, B., Gogia, H., Keane-Richmond, P., Gillespie, E., Hinchion, N., Gerber, J., Valentine, H., George, F., Garb, J., Jones, J., Gaffney, M., Smith, K., Friedlander, I., Morales, C., French, W., Gentry, P., Franco, M., Thrope, C., Frais, M., Solis, A., Forman, S., Slayton, C., Flores, E., Donahue, S., Fishbein, G., Drew, B., Fischell, T., Lim, G., Finkelstein, S., Shriver, D., Finkel, M., Calvo, M., Fialkow, J., Prior, J., Felten, W., Tang, N., Feldman, J., Tameron, A., Feld, L., Watkins, D., Fahmy, R., DeSalle, D., Everhart, B., Shipp, A., Ettinger, N., O'Brien, J., Johnson, C., Erenrich, N., Cristaldi, J., Ellis, J., Quick, R., Eldadah, Z., Dunn, K., Eade, J., Cullen, T., D'Souza, A., Habibi, S., Drozdiak, R., Olson, A., Dotani, I., Rodriguez, L., Donovan, D., Tisdale, L., DiGiovanna, M., Ucik, S., Dhar, S., Briscoe, C., Devenport, S., Waters, L., Desire, A., Steward, A., Desai, A., Carey, J., DeGarmo, R., Warmack, D., Dean, J., Debes, C., De Lemos, J., Ebreo, N., Davuluri, A., Dave, B., Dave, K., Wulf, A., Datta, S., Leka, G., Daniels, S., Morgan, T., Dang, N., Sarpola, N., Curtis, B., Nelson, L., Cowan, L., Masson, E., Cottiero, R., Mullinax, K., Cossu, S., Svadbik, L., Corbett, B., Martinez, E., Concha, M., Cole, J., Salpas, S., Colan, D., Bossaers, J., Cohen, R., Dutka, C., McClelland, M., Clay, A., Clapp, T., Bagby, J., Ciaramita, J., Sawaya, K., Chaturvedi, S., Tamayo, M., Charlat, M., Hatfield, G., 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L., Fedotov, S., Malynovsky, Y., Gorna, O., Lizogub, V., Kyyak, Y., Kupnovytska, I., Stets, R., Kraydashenko, O., Usan, N., Kraiz, I., Kaplan, P., Koval', O., Ohirko, O., Koval, V., Dvoieglazova, M., Kotseruba, V., Petyunina, O., Kopytsya, M., Vasylets, V., Kolomyyits, S., Gerasimenko, N., Kaydashev, I., Blihar, O., Karpenko, Y., Nevolina, I., Karpenko, O., Samburg, Y., Godlevska, O., Husyev, V., Horbach, L., Dzublik, Y., Gavrysyuk, V., Sorokivskyy, M., Faynyk, A., Vasilyeva, L., Dzyak, G., Kulynych, R., Dotsenko, S., Lebedynskaya, M., Bereznyakov, I., Vlasyuk, Z., Bazylevych, A., Azhdari, M., Batushkin, V., Zoghi, M., Yigit, Z., Yigit, F., Tandogan, I., Turgut, O., Oto, A., Kanadasi, M., Kabul, K., Ermis, C., Erdogan, D., Ceyhan, C., Cayli, M., Calik, A., Cakmak, N., Bayata, S., Ata, N., Demir, H., Akilli, H., Acikel, M., Puripun, E., Vorasettakarnkij, Y., Mekara, W., Sukonthasarn, A., Panpunuan, P., Sritara, P., Sripracha, A., Piyayotai, D., Bamrungpong, P., Laothavorn, P., Sriprasert, S., Kiatchoosakun, S., Sinthusopa, W., Kaewsuwanna, P., Pornchaiyasit, K., Jirasirirojanakorn, K., Kuo, J. Y., Yeh, H. I., Tsai, W. C., Lee, S. C., Ueng, K. C., Pan, Y. F., Tseng, W. K., Chiu, C. Z., Shyu, K. G., Lin, K. H., Pai, P. Y., Lee, J. T., Lin, T. H., Lai, W. T., Wang, C. L., Kuo, C. T., Chen, Y. F., Huang, J. L., Chen, Y. P., Hsia, C. H., Yeh, T. C., Chiou, C. W., Wu, Y. W., Chiang, F. T., Yu, W. C., Chiang, C. E., Wu, W. S., Cheng, C. C., Slater, I. Petrova, Moccetti, T., Broberg, M., Thulin, J., Gunnarsson, A., Stenberg, A., Sundholm, C., Ronn, F., Johansson, M., Rautio, A., Moodh, J., Randers, F., Eriksson, G., Malmqvist, L., Edlund, M., Kozak, P., Hakansson, E., Koskinen, P., Jernhed, H., Juul-Moller, S., Winberg, L., Herlitz, J., Karlsson, L., Engdahl, J., Ostberg, S., Dettmann, S., Bengtsson, A. Stener, Carlsson, T., Persson, L., Blomstrom, P., Andersson, R., Blom, K. Berndtsson, Akerberg, A., Appelros, P., Astier, L., Villuendas, R., Dachs Delgado, M., Terns, M., Fernandez Alvarez, R., Fernandez, M., Arias, J., Diaz-Pintado, M., Merino, J., Blanco Abril, S., Manzano, L., Barquero, R., Lopez Garcia-Aranda, V., Delgado, A., Hernandez Madrid, A., Moure, M., Gonzalez Juanatey, J., Perez Guevara, M., Diez Tejedor, E., Asensio, A., De Arce Borda, A., Calvo, G., Calvo, C., Cabero, P., Bruguera Cortada, J., Puertas, I., Blanco Coronado, J., Manzanal Rey, A., Arcocha Torres, M., Kim, J. Y., Rim, S. J., Na, J. O., Rha, S. W., Kwak, J. J., Namgung, J., Shin, D. G., Lee, S. H., Joung, B. Y., Lee, M. H., Chun, M. Y., Kim, Y. J., Seo, J. B., Kim, S. H., Park, S. J., Kim, J. S., Park, J. H., Kim, J. H., Park, M. S., Kim, J. T., Cha, M. J., Kim, H. S., Seo, J. S., Kim, D. S., Jin, E. S., Kim, C. J., Choi, K. J., Kang, D. H., Lee, J. M., Jeon, H. K., Jung, J. W., Hyon, M. S., Lee, H. W., Hong, T. J., Lee, K. H., Han, S. H., Oh, Y. S., Chung, W. S., Hong, K. S., Choi, H. H., Ryu, D. R., Cho, B. R., Kim, D. H., Cha, J. K., Han, M. G., Bae, H. J., Wessels, L., Venter, T., Le Roux, M., Van Zyl, L., Goosen, Y., Van Der Merwe, N., Johnston, H., Soma, P., Munnik, M., Snyders, F., Duki, Y., Naidoo, D., Taljaard, J., Mitha, I., Kelfkens, Y., Wilson, L., Gani, M., Nunkoo, T., Essop, M., Mostert, M., Engelbrecht, J., Botha, L., Ellis, G., Allman, J., Dalby, A., Poynton, M., Basson, M., Erasmus, L., Badenhorst, J., Bollova, D., Zareczky, P., Kokles, M., Zachar, A., Kmec, J., Slanina, M., Morsky, J., Ruffini, L., Fedacko, J., Pella, D., Mazur, J., Reptova, A., Kasperova, V., Hofmanova, J., Hranai, M., Hatala, R., Hatalova, K., Dzupinova, M., Dzupina, A., Vankova, L., Duris, T., Dulka, T., Dulkova, K., Kosmalova, V., Dukat, A., Banikova, A., Ambrovic, I., Ambrovicova, V., Tesic, M., Golshmid, M., Ruda, M., Topolnitchi, O., Castro, C., Ostojic, M., Tesic, B. 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Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., Wollaert, B., Beerts, C., Vrolix, M., Mestdagh, I., Vervoort, G., van Welden, J., Vanwelden, J., Derycker, K., Vandekerckhove, Y., Jacobs, C., Mehrle, A., Skinner, J., Meholick, A., Marti, J., Mega, J., Lack, A., Stockman, D., Huyberechts, D., Scavee, C., Clinckemaille, N., Parque, J., Raepers, M., Mairesse, G., Malmendier, D., Herzet, J., Meeusen, K., Heidbuchel, H., Tincani, G., Desfontaines, P., De Bruyne, L., De Tollenaere, M., de Koning, K., De Bleecker, J., Banaeian, F., Capiau, L., O'Shea, V., Szto, G., Perrett, L., Purnell, P., Batta, C., Paul, V., Li, J., McKeirnan, M., Morrison, H., Wright, J., Wright, A., Chung, A., Watkin, R., Gilchrist, M., Venkataraman, A., Lehman, R., Jones, S., Gates, P., Flecknoe-Brown, S., Silver, G., Davis, S., Kay, S., Dart, A., Slattery, A., Crimmins, D., Price-Smith, S., Colquhoun, D., Hoffmann, B., Arstall, M., Paraskevaidis, T., Anderson, C., Morell, Y., Vico, M., Teves, M., Sosa Liprandi, M., Morara, P., Severino, P., Buzzetti, C., Schygiel, P., Walker, M., Turner, W., Bridge, C., Storey, R., Goloboulicz, A., Schmidberg, J., Kennard, S., Sopher, M., McLaurin, B., Young, G., Kwong, Winghan J., Antman, Elliott M., Ruff, Christian T., Wang, J. H., Iriarte, M., Morissette, A., Wang, Kaijun, Li, Haiyan, and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,Complications ,Time Factors ,Pyridines ,Health Status ,Embolism ,Hemorrhage ,Arrhythmias ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Risk Factors ,Surveys and Questionnaires ,Internal medicine ,Atrial Fibrillation ,Humans ,Medicine ,In patient ,Prospective Studies ,030212 general & internal medicine ,anticoagulation ,Blood Coagulation ,Original Research ,Aged ,Aged, 80 and over ,Quality and Outcomes ,business.industry ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,bleeding ,medicine.disease ,Stroke ,Thiazoles ,Treatment Outcome ,quality of life ,utility ,Physical therapy ,Cardiology ,Female ,Warfarin ,Gastrointestinal Hemorrhage ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,Health Services and Outcomes Research ,Factor Xa Inhibitors - Abstract
Background The impact of different types of extracranial bleeding events on health‐related quality of life and health‐state utility among patients with atrial fibrillation is not well understood. Methods and Results The ENGAGE AF ‐ TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48) Trial compared edoxaban with warfarin with respect to the prevention of stroke or systemic embolism in atrial fibrillation. Data from the EuroQol‐5D ( EQ ‐5D‐3L) questionnaire, prospectively collected at 3‐month intervals for up to 48 months, were used to estimate the impact of different categories of bleeding events on health‐state utility over 12 months following the event. Longitudinal mixed‐effect models revealed that major gastrointestinal bleeds and major nongastrointestinal bleeds were associated with significant immediate decreases in utility scores (−0.029 [−0.044 to −0.014; P P =0.001], respectively). These effects decreased in magnitude over time, and were no longer significant for major nongastrointestinal bleeds at 9 months, but remained borderline significant for major gastrointestinal bleeds at 12 months. Clinically relevant nonmajor and minor bleeds were associated with smaller but measurable immediate impacts on utility (−0.010 [−0.016 to −0.005] and −0.016 [−0.024 to −0.008]; P Conclusions All categories of bleeding events were associated with negative impacts on health‐state utility in patients with atrial fibrillation. Major bleeds were associated with relatively large immediate decreases in utility scores that gradually diminished over 12 months; clinically relevant nonmajor and minor bleeds were associated with smaller immediate decreases in utility that persisted over 12 months. Clinical Trial Registration URL: https://www.clinicaltrials.gov/ . Unique identifier: NCT00781391.
- Published
- 2017
5. Ezetimibe added to statin therapy after acute coronary syndromes
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Cannon, Christopher P., Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. 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Jinich, D., Tam, K., Vogel, C., Aggarwal, R., Zakhary, B., Curtis, S., Lyster, M., Humphrey, K., Lavine, P., Fujise, K., Birnbaum, Y., Allen, J., Kesselbrenner, M., Michel, K., Staniloae, C., Liu, M., Sonel, A., Macioce-Caffas, A., Amidon, T., Leggett, J., Yedinak, S., Gudmundsson, G., Sabharwal, J., Dagefoerde, N., Wu, W., Meyerrose, G., Roongsritong, C., Jenkins, L., Lieberman, S., Sokol, S., Gutierrez, C., Nelson, C., Barrett, J., Hotchkiss, D., Farley, A., Atassi, K., Christy, L., Baig, M., Di Fazio, J., Meengs, M., Thomas, K., Surmitis, J., DeVault, S., Farhat, N., Hulyalkar, A., Riddell, L., Rivera, W., Sheynberg, B., Kobayashi, J., Katsaropoulos, J., Jan, M., Krucoff, M., Paterno, C., Chandrasekaran, S., Curry, R., Cassavar, D., Wheeler, M., McGarvey, J., Schwarz, L., Miller, E., Andrea, B., Carswell, B.S., Lurie, M., Patti, J., Bowden, W., Vasiliauskas, T., Latham, R., Schwartz, B., Bradford, L., Mattleman, S., Wertheimer, J., Goulden, D., Khan, M., Hawkins, B., Ostfeld, R., Mueller, H., Ash, Y., Wilson, V., Bayer, M., Marshall, J., Dobies, D., Dawson, G., Osman, A., Saba, F., Costello, T., Fuentes, F., Underwood, C., Vijay, N., Washam, M., Dietz, W., Glasgow, B., Mukherjee, S., Hinchion, N., Speirs, S., Thornley, A., Lee, K., Movahed, M., Strootman, D., Chernick, R., Parrott, C., Flock, C., Marques, V., Syzmanski, E., Rama, P., Domingo, D., Wu, L., Bauer, B., Dionisopoulos, P., Aggarwal, A., Holcomb, R., Foster, R., Hancock, T., Hargrove, J., Fletcher, A., Stine, R., Bullivant, M., Adams, K., Lohman, J., Klepper, V., Kabour, A., Neidhardt, J., Phillips, W., Tardiff, S., Aji, J., Corut, S., Foster, G., Firek, C., St Goar, F., Sumner, R., Davis, T., Schneider, R., Schneider, W., Villa, A., Desai, V., Chhabra, A., Banks, K., Herzog, W., Burley, T., Quyyumi, A., Smiley, W., Manocha, P., Fishbein, G., Weller, C., Coffman, A., Kim, C., Kedia, A., Firth, B., Rizvi, M., Dahiya, R., Foster, B., Balcells, E., Metzger, D.C., Lester, J., Bissett, J., Fahdi, I., Sides, E.A., Azrin, M., Martin, C., Quick, A., Conaway, D., Garg, M., Schallert, G., Lancaster, L., Mckissick, S., Atieh, M., Garbarino, J., Eisenberg, D., Uusinarkaus, K., Wirtemburg, P., Ellis, J., Cristaldi, J., Berglund, R., Negus, B., Pappas, J., Rocha, R., Nguyen, T., Stone, J., Janosik, D., Labovitz, A., Elmore, N., Dave, R., Loffredo, K., Gabriel, G., Snyder, C., Ahmed, O., Stone, H., Kelley, M., Diffenback, M., Friedman, B., Zirkle, J., Severa, L., Sample, S., Dignen, K., Raisinghani, A., Ben-Yehuda, O., Ghannadian, B., Moscoso, R., Mankowski, J., Boliek, W., Rukavina, M., Davis, W., Ledbetter, S., Handel, F., Mastouri, R., Mahenthiran, J., Foltz, J., Malhotra, V., Jonas, J., Berk, M., Singh, V., Nelson, M., Elsner, G., Gall, J., Kondo, N., Frank, S., Chandraratna, P., Ranasinghe, S., Ebrahimi, R., Treadwell, M., Walters, B., Hughes, L., Kramer, J., Kumar, K., Mente, T., Lachterman, B., Schifferdecker, B., Munshi, K., Sease, D., Waldo, D., Chandler, G., Manns, D., Nahhas, A., Kamalesh, M., Williams, V., Reich, D., Desalca, M., Sharma, S., Liston, M., Gupta, K., Costa, M., Altschuller, A., Lemmertz, K., Shanes, J., Hansen, C., Therrien, M., Mendelson, R., Ramnarine, R., Myers, G., Donovan, C., Klein, M., Fine, D., Owens, S., Murray, C., Ketroser, R., Heifetz, S., Darnell, Z., Touchon, R., Taghizadeh, B., Bohle, D., Norwood, D., Forrest, T., Jackson, S., Shumate, K., Bayles, A., Masroor, M., North, W.K., Fishberg, R., Merveil-Ceneus, B., Butcher, R., Menapace, F., Kilbride, S., Ramabadran, R.S., Loukinen, K., Khalil, J., Ramabadran, R., Walsh, S., Gill, S., Cyncar, R., McLachlan, J., Surakanti, V., Rusterholtz, L., Shoukfeh, F., Stephenson, L., Tsang, M., Nolan, V., Gilchrist, I., Jefferson, D., Feldman, T., Reyes, L., Santos, R., Little, W., Wesley, D., Gharib, W., Mendell, A., Esham, G., Kakavas, P., Whitcomb, C., Book, K., Bazzi, A., Alvarez, J., Cohen, Y., Ayres, T., Rhule, V., Labib, A., Schuler, P., Zughaib, M., Telck, K., Bikkina, M., Turnbull, K., Sharma, T., Orosz, S., Shah, R., Petrino, M., Hughes, M., Hershey, J., Hudock, D., Hui, P., Von Bakonyi, A., Arnold, A., Kappel, D., Pennock, G., Cloud, B., Tucker, K., Harp, L., Hoover, C., Eisenhauer, M., Roth, J., Young, C., Thai, H., Escalante, A., Bautista, J., Gazmuri, R., Nyland, J., Cubeddu, L., DeFranco, A., Dias, D., Fielding, M., Reeves, R., Hermany, P., Meissner-Dengler, S., Evans, M., Flores, E., Tannenbaum, A., McGarr, K., Moran, J., Stout, E., Allred, S., Henderson, D., Crandall, L., Strote, J., Voyles, W., Robeson, D., Bedoya, R., Omar, B., Pettyjohn, F., Revere, C., Coy, K., Margolis, J., Sotolongo, C., Scheffel, M., Munir, A., Shirwany, A., Douglas, L., Girala, R., Humphreys, R., Agarwal, J., Bankowski, D., Watson, R., Bishop, B., Klementowicz, P., Blais, D., Cohen, B., Lobur, E., Dimenna, J., Dempsey, K., Izzo, M., Bondi, L., Carell, E., Eaton, C., Saltiel, F., Grewal, G., Connolly, T., Little, T., Wiegman, P., Gips, S., Held, J., Paraschos, A., Quesada, R., Goudreau, E., Sears, M., Istfan, P., Holt, S., McClung, J., Nguyen, N., Quintana, O., Gottlieb, D., Knutson, T., Barringhaus, K., Lester, F., Sullivan, P., Rodriguez-Ospina, L., Cannon, Cp, Blazing, Ma, Giugliano, Rp, Mccagg, A, White, Ja, Theroux, P, Darius, H, Lewis, B, Ophuis, To, Jukema, Jw, De Ferrari, Gm, Ruzyllo, W, De Lucca, P, Im, K, Bohula, Ea, Reist, C, Wiviott, Sd, Tershakovec, Am, Musliner, Ta, Braunwald, E, Califf, Rm, for the IMPROVE-IT, Investigator, Cianflone, D, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], College of Information Science and Engineering, Ritsumeikan University, Montreal Heart Institute (MONTREAL HEART INSTITUTE), Laboratoire des Micro-algues toxiques, Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD), Interuniversity Cardiology Institute Netherlands, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Merck Sharp & Dohme Corp., Merck & Co. Inc, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Cannon, C.P., Blazing, M.A., Giugliano, R.P., Mccagg, A., White, J.A., Lewis, B.S., Jukema, J.W., De Lucca, P., Im, K., Bohula, E.A., Reist, C., Wiviott, S.D., Tershakovec, A.M., Musliner, T.A., Braunwald, E., Califf, R.M., for the IMPROVE-IT Investigators [.., C. Rapezzi, ], Other departments, Cannon, Christopher P, Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, and Califf, Robert M.
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Male ,Simvastatin ,acute coronary syndrome ,aged ,anticholesteremic agents ,azetidines ,cardiovascular diseases ,cholesterol, ldl ,double-blind method ,drug therapy, combination ,ezetimibe ,female ,humans ,hydroxymethylglutaryl-coa reductase inhibitors ,kaplan-meier estimate ,male ,middle aged ,simvastatin ,triglycerides ,medicine (all ,[SDV]Life Sciences [q-bio] ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Bococizumab ,Triglyceride ,chemistry.chemical_compound ,0302 clinical medicine ,Azetidine ,Cardiovascular Disease ,Anticholesteremic Agent ,Acute Coronary Syndrome ,Aged ,Anticholesteremic Agents ,Azetidines ,Cardiovascular Diseases ,Cholesterol, LDL ,Double-Blind Method ,Drug Therapy, Combination ,Female ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Middle Aged ,Triglycerides ,030212 general & internal medicine ,Medicine (all) ,Research Support, Non-U.S. Gov't ,Hazard ratio ,General Medicine ,Acute Coronary Syndrome, Aged ,Anticholesteremic Agents, Azetidines, Cardiovascular Diseases ,Ezetimibe, Female, Humans ,Male, Middle Aged ,3. Good health ,Multicenter Study ,Editorial ,Cholesterol ,Randomized Controlled Trial ,Combination ,Ezetimibe ,lipids (amino acids, peptides, and proteins) ,Human ,medicine.drug ,medicine.medical_specialty ,Acute Coronary Syndroms ,Urology ,Acute Coronary Syndrome/drug therapy ,Anticholesteremic Agents/adverse effects ,Anticholesteremic Agents/therapeutic use ,Azetidines/adverse effects ,Azetidines/therapeutic use ,Cardiovascular Diseases/epidemiology ,Cardiovascular Diseases/mortality ,Cardiovascular Diseases/prevention & control ,Cholesterol, LDL/blood ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ,Simvastatin/therapeutic use ,Triglycerides/blood ,NO ,LDL ,03 medical and health sciences ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Drug Therapy ,Internal medicine ,Journal Article ,medicine ,Comparative Study ,Alirocumab ,business.industry ,PCSK9 ,ta3121 ,Lomitapide ,DOENÇAS CARDIOVASCULARES ,Endocrinology ,chemistry ,Statin Therapy ,Hydroxymethylglutaryl-CoA Reductase Inhibitor ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known.METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years.RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (PCONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit. (Funded by Merck; IMPROVE-IT ClinicalTrials.gov number, NCT00202878.).
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- 2015
6. Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
- Author
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Pan, Y. F., Lim, G., Desire, A., Tseng, W. K., Rost, Natalia S., Grammer, M., Khetarpal, S., Waseem, M., Zellner, C., Roper, E., Amin, M., Harden, M., Sababathi, R., Valpas, S., Bourlios, P., Kawaguchi, A., Mavronasiou, E., Pandurangi, U., Shams, S., Dichristin, U., Purayil, M. Padinhare, Munemasa, M., Angel, J., Gurusamy, P., Berni, A., Platner, N., Zeltser, D., El Jarroudi, M., Kisos, D., Haruna, T., Bernhardt, P., Coisne, D., Nakahara, Y., Li, W. M., Karamitsos, C., Tziortziotis, A., Essop, M., Nunkoo, T., Gani, M., Wilson, L., Kelfkens, Y., Mitha, I., Taljaard, J., Naidoo, D., Duki, Y., Snyders, F., Munnik, M., Soma, P., Johnston, H., Patki, N., Jasani, B., Van Der Merwe, N., Goosen, Y., Van Zyl, L., Le Roux, M., Venter, T., Wessels, L., Bae, H. J., Han, M. G., Cha, J. K., Kim, D. H., Cho, B. R., Ryu, D. R., Choi, H. H., Hong, K. S., Chung, W. S., Oh, Y. S., Han, S. H., Lee, K. H., Hong, T. J., Lee, H. W., Hyon, M. S., Jung, J. W., Jeon, H. K., Lee, J. M., Kang, D. H., Choi, K. 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Rostasne, Palinkas, A., Berk, M., Nagy, A., Garman, V., Bensimhon, D., Swaim, D., Beinart, S., Craig, M., Bedwell, N., Luis-Valdes, M., Bedoya, R., Hoffman, T., Beasley, R., Kolumban, E., Merkely, B., Kiss, K., Wulf, M., Takeda, M., Benton, J., Bartkowiak, A., Gordon, L., Erdogan, D., Barrington, P., Faircloth, C., Barker, T., Altonen, D., Barber, M., Campbell, G., Baman, R., Batista, M., Baine, S., Thompson, B., Ayesu, K., Ermis, C., Alvarez, M., Sanchez, A., Bowen, L., Sanjurjo, M., Codutti, O., Saravia Toledo, S., Formoso, I., Schmidberg, J., Baldwin, E., Awasty, V., Cobos, D., Aude, Y., Strickland, S., Medvegy, M., Kiss, T., Attanti, S., Matoltsy, A., Rasmussen, L., Arouni, A., Shoaf, R., Arnold, T., York, T., Kabul, K., Kanadasi, M., Goloboulicz, A., Anderson, J., Schygiel, P., Buzzetti, C., Severino, P., Morara, P., Sosa Liprandi, M., Teves, M., Vico, M., Oto, A., Turgut, O., Persechino, F., Morell, Y., Amin, K., Lane, B., Alsheikh, T., MacDonald, H., Almquist, A., Anderson, C., Paraskevaidis, T., Kolk, R., Tandogan, I., Stern, A., Yigit, F., Yigit, Z., Arstall, M., Hoffmann, B., Colquhoun, D., Price-Smith, S., Crimmins, D., Slattery, A., Karakai, H. Horvathne, Lupkovics, G., Di Lenarda, A., Kovacs, Z., Gadepalli, R., Mariani, M., Kumagai, S., Luttermann, M., Krishnan, H., Dart, A., Venneklaas, U., Kay, S., Lueders, S., De Servi, S., Grosse, B., Davis, S., Baranyai, M., Silver, G., Flecknoe-Brown, S., Gates, P., Kovacs, I., Salminen, O., Koczka, M., Jakal, A., Jones, S., Pirelli, S., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Lehman, R., Kiss, R., Saha, D., Barai, A., Roy, D., Bekal, S., Feil, J. Felfoldine, Meusel, P., Morrison, H., Biscardi, R., Kis, E., Hirayama, A., Allison, J., Godsey, W., Aliyar, P., Genova-Peeva, E., Kosztyu, M., Kleinecke-Pohl, U., Alexander, J., Brubaker, S., Akhter, F., Schoen, B., Reddy, R., Shankar, A. Ravi, Jungmair, W., Schmid, S., Junggeburth, J., De Pace, D., Ahmadpour, H., De Caterina, R., Hussain, A., Kaik, J., Ahmad, A., Beck, P., Zoghi, M., Batushkin, V., Fink, P., Reiling, S., Miyamoto, N., Adler, P., McKeirnan, M., Li, J., Paul, V., Batta, C., Serup-Hansen, K., Vuriya, A., Horacek, T., Schuppe, M., Kanakaridisz, N., Varga, A., Kimizu, T., Purnell, P., Perrett, L., Kishore, R., Szto, G., O'Shea, V., Capiau, L., Banaeian, F., De Bleecker, J., de Koning, K., De Tollenaere, M., Kara, M., Fiok, J., Szatmari, J., De Bruyne, L., Edes, I., Tsukimine, A., Muskoczki, E., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Forgione, C., Harada, K., Dioszeghy, P., Almaraz, S. Padilla, Desfontaines, P., Tincani, G., Heidbuchel, H., Camas, L. Velasquez, Cuccia, C., Meeusen, K., Herzet, J., Malmendier, D., Guerra, L., Mairesse, G., Raepers, M., Parque, J., Clinckemaille, N., Scavee, C., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Arakawa, S., Huyberechts, D., Stockman, D., Jacobs, C., Vandekerckhove, Y., Svenningsen, A., Sand, N., Azhdari, M., Derycker, K., Peruzzotti, L., Comi, G., Vanwelden, J., Mino, K., Cervi, E., Sanchez, M., Gilat, T., van Welden, J., Vervoort, G., Mestdagh, I., Vrolix, M., Bazylevych, A., Vlasyuk, Z., Raae, D., Raymond, I., Beerts, C., Wollaert, B., Denie, D., Vincenzo de Paola, A. Amato, Coutinho, E., Lotufo, P. Andrade, de Melo, R. Ferreira, Atie, J., Motta, C., Alves da Costa, F. Augusto, Lahav, M., Estrada, M. Rodas, Ferraz, R. Franchin, Precoma, D. Bertolim, Guevara, S., Contzen, C., Weihrauch, D., Sehnem, E., Botelho, R., Cunha, S., Brondani, R., Fleck, N., Buhr, M., Kandekar, S., Ladenburger, K., Lavagnino, A. Ovando, Braun, R., Ishimaru, S., Chaves Junior, H., Silva, J., Costantini, C., Barroso, D., Jimenez, T., De Patta, M., Pereira, V., Duda, N., Bereznyakov, I., Laimer, R., Tomita, H., Ishii, Y., Dutra, O., Morgado, S., Saporito, W. Faustino, Seroqui, M., Ferreira, L., Araujo, E., Finimundi, H., Daitz, C., Gagliardi, R., Pereira, G., Gomes, M., Gomes, A., Guimaraes, A., Lebedynskaya, M., Petrovic, V., Overgaard, K., Ninho, L., Olsen, R., Nielsen, H., Jaeger, C., Barash, B., Veng-Olsen, T., Dotsenko, S., Pereira, L., Iversen, H., Madsen, H., Kulynych, R., Dzyak, G., Vasilyeva, L., Faynyk, A., Sorokivskyy, M., Gavrysyuk, V., Schnelzer, P., Ibsen, H., Adler, J., Dzublik, Y., Horbach, L., Husyev, V., Bouzo, M., Babbar, A., Loof, A., Blanc, J., Godlevska, O., Melgar, I. Guzman, Marcoviciu, D., Ramirez, V. de Leon, Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Decoulx, E., Samburg, Y., Jorge, J., Cury, C., Karpenko, O., Hassager, C., Milla, O. Ayau, Kaiser, S., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Almeida, A., Kalil, C., Radaelli, G., Sebba Barroso de Souza, W. Kunz, Morales, K., Labrova, R., Nevolina, I., Karpenko, Y., Leaes, P., Luiz, R. Osorio, Blihar, O., Kaydashev, I., Berbari, H., Spinar, J., Spacek, R., Almeida, J. Pimenta, Gozalo, A., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Gerasimenko, N., Pisova, J., Exarchou, E., Havlova, I., Petrova, I., Kifnidis, K., Reis, G., Kolomyyits, S., Peterka, K., Olsr, J., Bansal, N., Nechanicky, R., Vasylets, V., Kopytsya, M., Melichar, M., Krocova, E., Machova, V., Ludka, O., Petyunina, O., Kotseruba, V., Berrouschot, J., Kvasnicka, J., Avellar, K., Kuchar, R., Kovar, P., Katz Weiand, L. Reis, Korantanis, K., Kosek, Z., Kostkova, G., Leipelt, J., Rocha, J., Ishibashi, Y., Lohman, J., Panella, M., Nozaki, T., Abi-Mansour, P., Dvoieglazova, M., Pyrgakis, V., Koval, V., Ohirko, O., Kochrt, M., Kobza, R., Koval', O., Jirmar, R., Sakamoto, S., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Barros, R., Gregor, P., Rao, M., Jambula, H., Golan, L., Anzai, T., Rodrigues, L., Rocha, M. Rubia, Rodrigues, A., Rodrigues, D., dos Santos, F. Rossi, Pagnan, L. Goncalves, Sampaio, R., do Val, R., Saraiva, J., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., Burianova, H., Brtko, M., Pinto, B., and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,Pyridines ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Brain Ischemia ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Double-Blind Method ,Recurrence ,Edoxaban ,Internal medicine ,Atrial Fibrillation ,parasitic diseases ,Secondary Prevention ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Stroke ,Aged ,Advanced and Specialized Nursing ,business.industry ,Hazard ratio ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,Middle Aged ,medicine.disease ,nervous system diseases ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,TIMI ,medicine.drug - Abstract
Background and Purpose— Patients with atrial fibrillation and previous ischemic stroke (IS)/transient ischemic attack (TIA) are at high risk of recurrent cerebrovascular events despite anticoagulation. In this prespecified subgroup analysis, we compared warfarin with edoxaban in patients with versus without previous IS/TIA. Methods— ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) was a double-blind trial of 21 105 patients with atrial fibrillation randomized to warfarin (international normalized ratio, 2.0–3.0; median time-in-therapeutic range, 68.4%) versus once-daily edoxaban (higher-dose edoxaban regimen [HDER], 60/30 mg; lower-dose edoxaban regimen, 30/15 mg) with 2.8-year median follow-up. Primary end points included all stroke/systemic embolic events (efficacy) and major bleeding (safety). Because only HDER is approved, we focused on the comparison of HDER versus warfarin. Results— Of 5973 (28.3%) patients with previous IS/TIA, 67% had CHADS 2 (congestive heart failure, hypertension, age, diabetes, prior stroke/transient ischemic attack) >3 and 36% were ≥75 years. Compared with 15 132 without previous IS/TIA, patients with previous IS/TIA were at higher risk of both thromboembolism and bleeding (stroke/systemic embolic events 2.83% versus 1.42% per year; P P P P =0.02). No treatment subgroup interactions were found for primary efficacy ( P =0.86) or for intracranial hemorrhage ( P =0.28). Conclusions— Patients with atrial fibrillation with previous IS/TIA are at high risk of recurrent thromboembolism and bleeding. HDER is at least as effective and is safer than warfarin, regardless of the presence or the absence of previous IS or TIA. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
- Published
- 2016
7. Cardioversion of Atrial Fibrillation in ENGAGE AF-TIMI 48
- Author
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Seibert, H., Bolton, R., Florian, J., Nyman, K., Viitaniemi, J., Maenpaa, A., Laheaar, M., Lucijanic, T., Lappalainen, T., Jakala, P., Valpas, S., Hussi, E., Kaarleenkaski, S., Huikuri, H., Ratnik, E., Vahula, V., Rosenthal, A., Voitk, J., Paumets, M., Rivis, L., Laane, E., David, D., Kolk, R., Stern, A., Kaik, J., Serup-Hansen, K., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Svenningsen, A., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Eikelboom, J., Krider, J., Dufresne, M., Kubanska, A., du Preez, M., Talbot, P., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Chehayeb, R., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. 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Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. 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Perrone, Lioy, E., Penco, M., Bulgari, M., Metra, M., Babbolin, M., Merlini, P., Francalacci, G., Marino, P., Raggi, F., Lo Pinto, G., Gaggioli, G., Laffi, Laffi, Murena, E., Grassia, V., Bosco, B., Fattore, L., Di Niro, M., Di Pasquale, G., Mazzone, C., Di Lenarda, A., Mariani, M., De Servi, S., De Pace, D., De Caterina, R., Forgione, C., Cuccia, C., Peruzzotti, L., Comi, G., Cervi, E., Boriani, G., Giovannelli, F., Berni, A., Platner, N., Zeltser, D., Kisos, D., Tsalihin, D., Belatsky, V., Swissa, M., Aloni, I., Shochat, M., Sterlin, J., Schiff, E., Logvinenko, S., Rozenman, Y., Givoni, H., Ouzan, E., Karny, M., Lishner, M., Ben Ari, M., Lewis, B., Genin, I., Klainman, E., Majdoub, A., Hayek, T., Roshrosh, M., Hasin, Y., Dagan, T., Grossman, E., Rouwaida, S., Gottlieb, S., Goldhaber, M., Goldhaber, A., Ghantous, R., Francis, A., Ron, G. Avraham, Elias, M., Gilat, T., Lahav, M., Marcoviciu, D., Dicker, D., Lasri, E., Atar, S., Dharmarao, A., Zanwar, I., Thakur, B., Vinod, M. 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Padinhare, Angel, J., Gurusamy, P., Oomaan, A., Natarajan, S., Narendra, J., Shelke, S., Namjoshi, D., Francis, V., Menon, J., Sharma, P., Mathur, A., Bhaskarwar, P., Mardikar, H., Kale, M., Lavhe, P., Anthony, A., Kumbla, M., Francis, J., Kumar, A., Karpuram, M., Kumar, P., Lawande, A., Kulkarni, G., Deokar, M., Kulkarni, R., Kotiwale, V., Krishnan, H., Kishore, R., Kandekar, S., Kandekar, B., Raut, N., Kale, V., Joshi, H., Thomas, R., Joseph, J., Oommen, D., Joseph, S., Pahuja, M., Jain, R., Ghume, A., Hiremath, J., Thakor, G., Hardas, S., Savanth, P., Hadan, S., Singh, P., Gupta, J., Saini, A., Goyal, N., Mali, N., Chopda, M., Karnwal, N., Somaraju, B., Calambur, N., Bhuti, M., Biniwale, A., Rathi, A., Bhargava, V., Solanki, R., Bharani, A., Surushe, S., Benjarge, P., Sheth, T., Banker, D., Reddy, J., Babu, R., Rao, B., Babu, P., Shaikh, A., Avvaru, G., Shree, R., Arora, V., Memon, A., Arneja, J., Ranka, R., Agarwal, D., Abdullakutty, J., Malhan, S., Kincses, M., Vertes, A., Marosi, A., Tomcsanyi, J., Szakal, I., Sipos, T., Ruzsa, D., Simor, T., Bognar, A., Sayour, A., Toth, S. Rostasne, Palinkas, A., Nagy, A., Kolumban, E., Merkely, B., Kiss, K., Medvegy, M., Kiss, T., Matoltsy, A., Karakai, H. Horvathne, Lupkovics, G., Kovacs, Z., Baranyai, M., Kovacs, I., Koczka, M., Jakal, A., Kiss, R., Feil, J. Felfoldine, Kis, E., Kosztyu, M., Kanakaridisz, N., Varga, A., Fiok, J., Szatmari, J., Edes, I., Muskoczki, E., Dioszeghy, P., Almaraz, S. Padilla, Camas, L. Velasquez, Guerra, L., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Sanchez, M., Estrada, M. Rodas, Guevara, S., Lavagnino, A. Ovando, Jimenez, T., Melgar, I. Guzman, Ramirez, V. de Leon, Milla, O. Ayau, Korantanis, K., Pyrgakis, V., Kartsagkoulis, E., Olympios, C., Dimitra, K., Moschos, N., Daskalaki, A., Kifnidis, K., Exarchou, E., Karamitsos, C., Tziortziotis, A., Bourlios, P., Mavronasiou, E., Alexopoulos, D., Winter, K., Wolde, C., Buelow-Johansen, B., Winkelmann, B., Weyland, K., Buchholz, M., Voehringer, Voehringer, Ludwig, I., Veltkamp, R., Zarpentin, C., Taggeselle, J., Stoehring, R., Bonin, K., Spitzer, S., Baylacher, M., Sohn, H., Gold, G., Hellmers, J., Schreckenberg, A., Schmidt, M., Schmidt, A., Schiewe, C., Dreykluft, K., Finsterbusch, T., Schenkenberger, I., Frommhold, R., Schellong, S., Szymanowski, N., Schaefer, A., Kuehlenborg, A., Rinke, A., Pilipenko, H., Rack, K., Kuhlmann, M., Proskynitopoulos, N., Pohl, W., Lewinsky, D., Piechatzek, R., Raddatz, K., Mueller-Glamann, M., Barbera, S., Muegge, A., Vogt, S., Mitrovic, V., Frahm, E., Meyer-Pannwitt, U., Braemer, U., Meissner, G., Hoefer, K., Maus, O., Wulf, M., Luttermann, M., Venneklaas, U., Lueders, S., Grosse, B., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Meusel, P., Kleinecke-Pohl, U., Schoen, B., Jungmair, W., Schmid, S., Junggeburth, J., Fink, P., Horacek, T., Schuppe, M., Hoffmann, S., Dorn, S., Hoffmann, U., Bobbie, C., Dieckheuer, U., Heuer, H., Peitz, M., Hartmann, A., Otto, A., Grigat, C., Manuela, W., Fuchs, R., Schneider, K., Forck-Boedeker, K., Faghih, M., Herfurth, B., Drescher, T., Kranz, P., Degtyareva, E., Ayasse, D., Daut, W., Kara, M., Contzen, C., Weihrauch, D., Buhr, M., Ladenburger, K., Braun, R., Schnelzer, P., You, Z. G., Bouzo, M., Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Berrouschot, J., Dichristin, U., Bernhardt, P., Wurow, A., Al-Zoebi, A., Duprat, C., Roudaut, R., Leparree, S., Poulard, J., Corbut, S., Kacet, S., Deruche, E., Hermida, J., Arfaoui, M., Dinanian, S., El Jarroudi, M., Decoulx, E., Berger, N., Coisne, D., Dias, P., Blanc, J., Talajic, M., Berbari, H., Belhassane, A., Boyer, M., Babuty, D., Boursin, P., Amarenco, P., El Jarroudi, F., Agraou, B., Le Heuzey, J., Nappila, H., Virtanen, V., Salminen, O., Rasi, H., Sankari, T., Fortin, C., Gilchrist, M., Zondag, M., Dewar, C., Lainesse, A., Roth, M., Viau, C., St-Germain, L., Mucha, M., Lam, S., Lam, H., Lichtenstein, T., Roberts, P., Luton, R., Douglas, S., Ma, P., Seib, M., MacCallum, C., Matthews, J., Malette, P., Vaillancourt, T., Maranda, C., Studenikow, E., Mawji, A., Morely, A., Morrison, D., Nicholson, R., Venkataraman, A., Walker, M., Lamoureux, U., Wright, L., Ebano, P., Storey, R., Price, R., Pye, M., Flint, L., Newby, D., Andrews, A., Murdoch, D., Helliwell, L., Blagden, M., MacCallum, P., Kennard, S., Sopher, M., Young, G., Senior, R., Brown, R., Lip, G., Najarali, A., Dunn, S., More, R., Isted, C., Maxwell, T., Jones, D., Standring, R., Hoag, G., Marazzi, P., McGhee, C., Ho, V., Ho, K., Scott, L., MacLeod, M., O'Hara, G., Heath, J., Finlayson, M., Hatheway, R., Beeton, I., Linker, N., Wright, J., Wright, A., Chung, A., Watkin, R., Atkinson, C., Houbraken, D., Lindsay, S., Turner, W., Ramasamy, V., Lie, F., Avery, D., Bridge, C., Douglas, H., D'Costa, D., Wilmott, R., Duff, J., Huynh, T., Camm, J., Perkins, L., Kouz, S., Roy, M., Labonte, R., Choy, A., Davies, D., Chapman, O., Dougal, K., and Yalcin, R.
- Published
- 2016
8. Stroke and Mortality Risk in Patients With Various Patterns of Atrial Fibrillation: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
- Author
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Jones, D., Gu, X. J., Liu, L., Grammer, M., Waseem, M., Roper, E., Harden, M., Zellner, C., Mason, T., Zeig, S., Curtis, S., Zakhary, B., Yousuf, K., Wharton, S., VonGerichten, S., Willis, J., Dowling, C., Williams, R., Gibson, C., Williams, D., Truva, C., Westcott, J., St Laurent, B., Weiss, R., Sanchez, G., Waxman, F., Locklear, T., Ward, S., Renaud, K., Walsh, R., Kilcup, S., Vossler, M., Washam, M., Vijay, N., Warren, K., Vicari, R., Parsons, T., Verma, S., Cardoza, T., Vemireddy, D., Harrelson, K. 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J., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Talajic, M., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Campisto, Y., Morissette, A., Sussman, J., Gao, M., Frahm, E., Golan, L., Mitrovic, V., Zheng, Y., Zapata Staub, J., Zheng, X., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., Burianova, H., Brtko, M., Kailey, P., Retamal Matus, L., Fonseca, J., Han, R. J., Velthuysen, G., Bugueno, C., Orozco Linares, L., Bobbie, C., Heath, J., Lopez Giraldo, D., Raddatz, K., Zhao, X. L., Voehringer, Voehringer, Scott, L., Ho, K., Ho, V., Chen, X. P., Car, S., Hoag, G., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Kunkelova, V., Najarali, A., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Zhang, X., Dong, Y. G., Standring, R., Feng, C., Fu, G. S., Wang, J. Q., Beeton, I., Dunn, S., Blagden, M., Price, R., Camm, J., Dougal, K., Mondaca Mondaca, P., Chapman, O., Davies, D., Choy, A., Duff, J., Zheng, Z. Q., Wilmott, R., D'Costa, D., Douglas, H., Lie, F., Ramasamy, V., Lindsay, S., Atkinson, C., Moncada Corredor, M., Linker, N., Finlayson, M., Lip, G., Brown, R., MacCallum, P., Ebano, P., MacLeod, M., McGhee, C., Marazzi, P., Maxwell, T., Isted, C., More, R., Helliwell, L., Murdoch, D., Andrews, A., Newby, D., Flint, L., Pye, M., Wright, L., Avery, D., Senior, R., Young, G., Sopher, M., Kennard, S., Storey, R., Zhang, P., Bridge, C., Hong, K., Turner, W., Walker, M., Venkataraman, A., Gilchrist, M., Watkin, R., Chung, A., Wright, A., Wright, J., Cobos, J., Mueller-Glamann, M., Yang, Y. J., Jeric, M., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Berka, L., Xu, J. H., You, Z. G., Li, Y. E., Syan, G., Hoefer, K., Rivera Rodriguez, E., Brodova, P., Ludwig, I., Obreque, C., Manzur, F., Builes, A., Hoffmann, U., Jaramillo Munoz, C., Dorn, S., Veltkamp, R., Hoffmann, S., Li, B. G., Potthoff, S., Bar, M., Vogt, S., Delgado, P., Zhou, S. X., Schuppe, M., Bergovec, M., Muegge, A., Teitelbaum, J., Barbera, S., Horacek, T., Torres Carrasco, G., Vrazic, H., Zhang, Y. L., Ciglenecki, N., Liao, D. N., Pincetti, C., Fink, P., Teitelbaum, I., Carmona Perez, M., Junggeburth, J., Liu, Y., Schmid, S., Li, Z. Q., Jungmair, W., Spitzer, S., Opazo, M., Lu, Z. H., Tusek, S., Ferri Certic, J., Romic, I., Francetic, I., Makar Ausperger, K., Jelic, V., Jaksic Jurinjak, S., Knezevic, A., Lichtenstein, T., Lam, H., Bakliza, Z., Sutalo, K., Lam, S., Romero Llamas, R., Ma, S. M., Huynh, T., St-Germain, L., Luton, R., Accini, J., Lainesse, A., Perkins, L., Douglas, S., Dewar, C., Ma, P., Kouz, S., Kirner, D., Steiner, R., Matthews, J., MacCallum, C., Cvitkusic Lukenda, K., Schoen, B., Kleinecke-Pohl, U., Meusel, P., Koenig, H., Bauch, F., Lohrbaecher-Kozak, I., Grosse, B., Lueders, S., Venneklaas, U., Luttermann, M., Wulf, M., Maus, O., Seib, M., Malette, P., Roberts, P., Yang, Z. Y., Roy, M., Labonte, R., Kong, Y. Q., Samardzic, P., Qu, Z., Hong, L., Buksa, B., Qiu, Y., Tremblay, M., Talbot, P., Accini, M., Hernandez, H., Wang, D. M., Qi, S. Y., Corbalan, R., Wang, G. P., Cano, N., Aldana Diaz, I., Shi, X. J., Martinez, D., Wu, S. L., Fernandez Ruiz, R., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Wei, M., Leon Pineda, L., Arroyave, C., Lopetegui, M., Arratia Diaz, P., Huang, D., Florenzano, F., Parada, A., Bonin, K., Delgado Restrepo, J., Stoehring, R., Taggeselle, J., Zarpentin, C., Huikuri, Heikke, Puripun, E., Yarows, S., Giugliano, Robert P., Scirica, Benjamin M., Wood, K., Sheehan, T., Yasin, M., Worley, S., Ruff, Christian T., Link, Mark S., Pointer, S., Capasso-Gulve, E., Yi, J., Dongas, B., and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,Pyridines ,medicine.medical_treatment ,Factor Xa Inhibitor ,Hemorrhage ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Risk Factors ,Physiology (medical) ,Internal medicine ,Thromboembolism ,Atrial Fibrillation ,Medicine ,Humans ,atrial fibrillation ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Stroke ,Aged ,business.industry ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,thromboembolism ,bleeding ,medicine.disease ,mortality ,stroke ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,medicine.drug ,Factor Xa Inhibitors - Abstract
Background— Whether the pattern of atrial fibrillation (AF) modifies the risk/benefit of anticoagulation is controversial. In ENGAGE AF-TIMI 48 trial (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48), the factor Xa inhibitor edoxaban was noninferior to warfarin in preventing stroke or systemic embolic events and significantly reduced bleeding and cardiovascular mortality. However, detailed analyses by AF pattern have not been reported. Methods and Results— The 21 105 patients were categorized as having paroxysmal (P -adj =0.015) and permanent AF (1.95%/year; P -adj =0.004). Overall, all-cause mortality also was lower with paroxysmal (3.0%/year) compared with persistent (4.4%/year; P -adj P -adj Conclusions— In ENGAGE AF-TIMI 48 trial, patients with paroxysmal AF suffered fewer thromboembolic events and deaths compared with those with persistent and permanent AF. The efficacy and safety profile of edoxaban as compared with warfarin was consistent across the 3 patterns of AF. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
- Published
- 2016
9. Cerebrovascular events in 21 105 patients with atrial fibrillation randomized to edoxaban versus warfarin: Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48
- Author
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Dougal, K., Venkataraman, A., Murdoch, D., Blagden, M., Dunn, S., MacCallum, P., Young, G., Lip, G., Senior, R., Brown, R., Sopher, M., Ebano, P., Linker, N., Atkinson, C., Lindsay, S., MacLeod, M., More, R., Ramasamy, V., Chapman, O., Lie, F., Beeton, I., McGhee, C., Wilmott, R., Dickinson, D., Douglas, H., Davies, D., D'Costa, D., Finlayson, M., Wright, A., Avery, D., Wright, L., Pye, M., Marazzi, P., Flint, L., Newby, D., Kennard, S., Andrews, A., Storey, R., Helliwell, L., Bridge, C., Choy, A., Turner, W., Walker, M., Wright, J., Smith, S., Jones, D., Maxwell, T., Chung, A., Isted, C., Cohen, A., Camm, J., Price, R., Watkin, R., Gilchrist, M., Duff, J., Aggarwal, R., Eldred, R., Adler, P., Chehayeb, R., Vandekerckhove, Y., Gordon, L., Jones, S., Young, C., Coyle, G. Stagi, Ferguson, D., Lang, J., Simmons, T., Langevin, E., Faucett, S., Ledbetter, L., Royse, H., Lentz, M., Smith, D., Lesser, M., Hartley, L., Lewis, D., Bonds, C., Lillestol, M., Miller, D., Ling, L., Murphy, R., Littlefield, R., Wofford, E., Lomnitz, D., Shah, D., Lone, B., Davids, M., Looby, R., Ault, S., Lui, H., Wright, H., Lurie, M., Edelstein, J., Macomber, J., Bush, D., Magee, A., Doctor, A., Mainigi, S., Lisiecki, B., Makam, S., Casas, R., Mandviwala, M., Hernandez, S., Marar, I., Rabadi-Marar, D., Marenberg, M., Bedenko, E., Massin, E., Hicks, T., McCartney, M., Stubbs, L., McGarvey, J., Schwarz, L., McGuire, K., Miranda, J., McKenzie, M., Rodkey, K., McKnight, T., Paul, J., McLaurin, B., Lack, A., Mega, J., Marti, J., Meholick, A., Skinner, J., Mehrle, A., Wall, J., Mendelson, R., Cervellione, K., Mercado, A., Cajulis, C., Michlin, B., Romero-Colon, J., Milas, J., Sanders, D., Miller, R., Sanchez, S., Miller, S., Gryczan, J., Mody, F., Strugatsky, S., Moran, J., Garner, S., Morledge, J., Bowman, B., Mouhaffel, A., Parrott, N., Mounsey, P., Schuler, C., Mowdy, M., Todd, S., Mullen, P., Raziano, S., Murphy, A., Oehmann, V., Nadar, V., Parker, A., Naidu, J., West, M., Nallasivan, M., Goza, J., Nguyen, T., Nomanee, S., Nielsen, R., Wilmot, M., Oberoi, M., Thakkar, N., Oppenheimer, K., McCormick, J., Orchard, R., Garcia, L., Osborne, J., Gonzalez, M., Oza, S., Joseph, L., Patnam, S., Dennison, K., Pavon, H., Gorry, N., Pearlstein, R., Montayne, S., Pentz, W., Duncan, D., Peters, P., Chacon, L., Petruzziello, F., Morlando, F., Pettis, K., Brown, F., Pezzella, S., Kirk, D., Poulathas, A., Cush, S., Pratt, R., Neeper, L., Pribble, A., Lowe, K., Pudi, K., Sham, L., Pugeda, J., Ebert, J., Quadrel, M., Rafla, E., Quinlan, E., Reed, C., Quinn, J., Hemmen, C., Rama, P., Domingo, D., Redondo, V., Wroblewski, J., Renzi, M., Stanley, E., Richwine, R., Pazier, P., Roberts, J., Riofrio, K., Braun, D., Robinson, J., Cherrico, M., Roehll, W., Hollihan, P., Rosado, J., Barnhorst, M., Rosen, R., Martin, C., Ross, S., Freeman, R., Ruoff, G., Nelson, T., Sacco, J., Ball, E., Samal, A., Schomburg, J., Sandberg, J., Lafave, J., Savin, V., Clifton, R., Schaefer, S., Fekete, A., Schneider, R., Schneider, W., Schulman, D., Mercer, S., Seals, A., Ullig, T., Holt, A., Seide, H., Mather, N., Shah, G., Witt, P., Shalaby, A., Seese, M., Shanes, J., Fleets, J., Shaoulian, E., Hren, A., Sheikh, K., Hengerer, T., Shih, H., Browning, J., Shoukfeh, M., Stephenson, L., Siler, T., Champagne, M., Simpson, P., Meyer, R., Singh, N., Turner, K., Singh, V., Nelson, M., Skierka, R., Hughes, B., Keene, R., Smith, R., Hodnett, P., Spangenthal, S., Thomason, L., Sperling, M., Vasquez, E., Spivack, E., McCartney, P., Staniloae, C., Liu, M., Steljes, A., Cox, C., Struble, R., Vittitow, T., Suresh, D., Frost, J., Swerchowsky, V., Freemyer, D., Szulawski, I., Herwehe, S., Tahirkheli, N., Springer, K., Takata, T., Bruton, T., Talano, J., Leo, L., Tami, L., Corchado, D., Tatarko, M., Swauger, M., Tawney, K., Dastoli, K., Teague, S., Young, K., Tee, H., Mitchell, T., Teixeira, J., Southam, D., Torres, M., Romero, N., Tucker, P., Salas, L., Updegrove, J., Hanna, K., Val-Mejias, J., Harrelson, K. 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Vogelmann, O., Braunwald, Eugene, Antman, Elliott M., Mercuri, Michele, Shi, Minggao, Dave, Jay, Duggal, Anil, Betcher, Joshua M., Grip, Laura T., Murphy, Sabina A., Deenadayalu, Naveen, Lowe, Cheryl, Wiviott, Stephen D., Silverman, Scott, Gowda, S., Rafala, E., Graham, S., Bonora, M., Griffin, S., Aull, L., Griffin, J., Goodman, V., Grossman, C., Davis, A., Grove, D., Mabe, K., Guarino, J., Gabela, W., Guarnieri, T., Guerrero, Guerrero, Foster, B., Guthrie, R., Felsman, D., Gvora, T., McLean, R., Rost, Natalia S., Hack, T., Morelli, L., Hamroff, G., Bentivenga, L., Han, M., Cavanna, L., Harris, J., Bobade, M., Hearne, S., Krater, C., Heiman, M., Dandekar, U., Henderson, D., Millard, D., Henry, S., Harkins, V., Hermany, P., Batchell, K., Herrod, J., Miranda, D., Herson, S., Carey, G., Hinchman, D., Vieira, P., Hippert, R., Dutter, S., Hoekstra, J., Homan, J., Homayouni, A., Horton, K., Sloss, D., Hotchkiss, D., Turner, N., Houchin, V., Adams, K., Howard, V., Hays, D., Howard, L., 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J., Qiu, Y., Hong, L., You, Z. G., Hong, K., Zhang, P., Fu, G. S., Feng, C., Dong, Y. G., Zhang, X., Chen, X. P., Xie, X. D., Chen, J. Z., Xu, G. L., Bai, F., Grandon Azua, M., Yovaniniz, P., Lara Lara, C., Stockins, B., Campisto, Y., Zapata Staub, J., Potthoff, S., Torres Carrasco, G., Pincetti, C., Carmona Perez, M., Opazo, M., Romero Llamas, R., Martinez, D., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Lopetegui, M., Arratia Diaz, P., Florenzano, F., Parada, A., Corbalan, R., Obreque, C., Cobos, J., Mondaca Mondaca, P., Bugueno, C., Retamal Matus, L., Balboa, W., Mabee, J., Woodford, T., Caterini, T., Wharton, S., Morley, A., Wahby, R., Giesbrecht, L., Velthuysen, G., Teitelbaum, J., Teitelbaum, I., Tremblay, M., Talbot, P., David, D., Talajic, M., Bobbie, C., Syan, G., Kailey, P., Sussman, J., Morissette, A., St-Hilaire, R., Silverio, G., Shu, D., Marchand, C., Rupka, D., Bozek, B., Ricci, J., Nethercott, C., Qureshi, A., Turri, L., Polasek, P., Sardin, V., Pesant, Y., Carroll, L., Parkash, R., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Garb, J., Najarali, A., Krider, J., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Malette, P., Matthews, J., MacCallum, C., Seib, M., Ma, P., Douglas, S., Luton, R., Roberts, P., Lichtenstein, T., Lam, H., Lam, S., St-Germain, L., Lainesse, A., Dewar, C., Labonte, R., Roy, M., Kouz, S., Perkins, L., Huynh, T., Standring, R., Hoag, G., Ho, V., Ho, K., Scott, L., Heath, J., Hatheway, R., Houbraken, D., Viau, C., Fortin, C., Zondag, M., Eikelboom, J., Dufresne, M., Kubanska, A., du Preez, M., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., and Wollaert, B.
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,medicine.drug_class ,Pyridines ,Factor Xa Inhibitor ,Infarction ,chemistry.chemical_compound ,Double-Blind Method ,Edoxaban ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Stroke ,Aged ,Advanced and Specialized Nursing ,Dose-Response Relationship, Drug ,business.industry ,Anticoagulant ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Background and Purpose— The once-daily oral factor Xa inhibitor, edoxaban, is as effective as warfarin in preventing stroke and systemic embolism while decreasing bleeding in a phase III trial of patients with atrial fibrillation at moderate–high stroke risk. Limited data regarding cerebrovascular events with edoxaban were reported previously. Methods— We analyzed the subtypes of cerebrovascular events in 21 105 patients participating in Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) comparing outcomes among patients randomized to warfarin versus 2 edoxaban regimens (high dose, low dose). The primary end point for this prespecified analysis of cerebrovascular events was all stroke (ischemic plus hemorrhagic), defined as an abrupt onset of focal neurological deficit because of infarction or bleeding with symptoms lasting ≥24 hours or fatal in Results— Patients randomized to high-dose edoxaban had fewer strokes on-treatment (hazard ratio, 0.80; 95% confidence interval, 0.65–0.98) than warfarin (median time-in-therapeutic range, 68.4%); patients in the low-dose edoxaban group had similar rates (hazard ratio, 1.10 versus warfarin; 95% confidence interval, 0.91–1.32). Rates of ischemic stroke or transient ischemic attack were similar with high-dose edoxaban (1.76% per year) and warfarin (1.73% per year; P =0.81), but more frequent with low-dose edoxaban (2.48% per year; P Conclusions— In patients with atrial fibrillation, once-daily edoxaban was as effective as warfarin in preventing all strokes, with significant reductions in various subtypes of intracranial bleeding. Ischemic cerebrovascular event rates were similar with high-dose edoxaban and warfarin, whereas low-dose edoxaban was less effective than warfarin. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
- Published
- 2014
10. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes.
- Author
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IMPROVE-IT Investigators, Musliner, T., Tershakovec, A., Gurfinkel, E., Aylward, P., Tonkin, A., Maurer, G., Van de Werf, F., Nicolau, J.C., Theroux, P., Genest, J., Armstrong, P., Corbalan, R., Isaza, D., Spinar, J., Grande, P., Voitk, J., Kesaniemi, A., Bassand, J.P., Farnier, M., Darius, H., Keltai, M., Mathur, A., Mittal, S., Reddy, K., Lewis, B., De Ferrari, G.M., Ophuis, T.O., Jukema, J., White, H., Pedersen, T., Britto, F., Ruzyllo, W., Carrageta, M., Duris, T., Dalby, A., Seung, K.B., Lopez-Sendon, J., Dellborg, M., Mach, F., Guneri, S., Parkhomenko, A., Brady, A., Cannon, C., Blazing, M., Ballantyne, C., de Lemos, J., Kleiman, N., McGuire, D.K., Centeno, E., Casalins, M., Cartasegna, L., Beltrano, M.C., Guerrero, R., Fanuele, M., Berra, F., Egido, J., Colombo, H., Dellatorre, M., Terns, P., Blumberg, E., Reges, P., Azize, G., Ramos, H., Fernandez, R., Carlessi, C., Milesi, R., Schmuck, R., Duronto, E., Procopio, G., Carlevaro, O., Maffeo, H., Beloscar, J., Viso, M., Hominal, M., Castoldi, M., Bluguermann, J., Mauro, D., Macin, S., Cocco, N., Ruiz, N., Ricart, J., Lozada, A., Nani, S., Turri, D., Fernandez, H., Caruso, O., Zarandon, R., Bono, J., Arias, V., Allall, O., Marino, J., Cusimano, S., Schygiel, P., Buzetti, C., Penaloza, N., Berli, M., Worthley, S., Roach, A., Chew, D., Wright, T., Leitch, J., Hicks, E., Rankin, J., Venn-Edmonds, C., Lehman, R., Morrison, H., Shaw, J., Mak, V., Hii, C., Smith, K., Cross, D., Lilwall, L., Nelson, G., Loxton, A., Horowitz, J., Rose, J., Steinwender, C., Leisch, F., Kammler, J., Brussee, H., Zweiker, R., Niederl, E., Weihs, W., Giorgio, G., Lang, I., Drexel, H., Zanolin, D., Hoppe, U., Atzenhofer-Baumgartner, K., Pichler, M., Hainzer, D., Eber, B., Pichler, F., Foeger, B., Wechselberger, T., Mayr, H., Hofer, J., Stockenhuber, F., Warlits, B., Huber, K., Egger, F., Weidinger, F., Ziegler, B., Jirak, P., Metzler, B., Pachinger, O., Wanitschek, M., Auer, J., Grabscheit, G., Podczeck-Schweighofer, A., Priesnitz, T., Frank, H., El Allaf, D., Marechal, P., Roosen, J., Joly, E., Lefebvre, P., Arend, C., Sinnaeve, P., De Velder, L., Hellemans, S., Vanhauwaert, B., Van Dorpe, A., Heyse, A., Vantomme, C., Striekwold, H., Van Den Broeck, D., Lancellotti, P., Schoors, D., Lemoine, I., Taeymans, Y., De Wolf, L., Brike, C., Vercauteren, S., Tahon, S., Vervoort, G., Mestdagh, I., Pirenne, B., Cardinal, F., Lips, S., Dujardin, K., Debrouwer, K., Dhooghe, G., Holvoet, G., van de Borne, P., Renard, M., De Clippel, M., Lesseliers, H., Van Miert, N., Saraiva, J., Vicente, C., Rossi, P., Dos Santos, L.B., Duda, N., Tognon, A.P., Serrano, C., Gomes, F.L., Manenti, E.R., Silveira, D.S., Maia, L., Mouco, O.M., Paiva, M., Antonangelo, A., de Souza, J., Lino, E.A., Leães, P., Blacher, M.G., Kormann, A., Ultramari, F.T., Dutra, O., Mendelski, A.M., Morgado, S., Ardito, W., Greque, G., Ardito, R.V., Pimentel Filho, P., Zucchetti, C., Alves, A., Seabra, A.M., Mattos, M., Miranda, L.F., Silva, D., Uehara, R.M., Marin Neto, J., Schmidt, A., Braga, J., Rodrigues, A., Abrantes, J., Pinheiro, L., Bodanese, L., Magedanz, É.H., Piegas, L., Dos Santos, E.S., Wainstein, M., Ribeiro, J., Stein, R., Marino, R., Machado, V.M., Moraes Junior, J., Guimarães, S., da Costa, F.A., Ferraz, R.F., Albuquerque, D., Rocha, R.M., de Carvalho Moreira, R., Dohmann, H., Costantini, C., Tarastchuk, J.C., Coelho, O., Cirillo, W., Sousa, A., Almeira, A.S., Stefanini, E., Silva, F., Teixeira, M., da Cunha, C., Précoma, D., Facchi, T.L., Rupka, D., Thiessen, S., Warnica, J., Smith, B., Della Siega, A., Klinke, P., Nelson, S., Dion, D., Gilbert, N., Hui, W., Kvill, L., Sussex, B., Luther, A., Dupuis, R., Ouimet, F., Pandey, A., Clarus, S., Senaratne, M., Ferdinandis, H., Mukherjee, A., Bozek, B., Vizel, S., Markov, G., Zimmermann, R., Stephens, W., Tremblay, B., Wong, G., Uchida, N., Brossoit, R., Peck, C., Van Kieu, C., Forgione, M., Bata, I., Cossett, J., Kostuk, W., Arnold, M., Bone, C., Grondin, F., Bilodeau, N., Gosselin, G., David, M., Giannoccaro, J., Beresford, P., Polasek, P., Roberts, P., Doucet, M., Beaudry, M., Cheung, S., Cleveland, T., Bhargava, R., McCallum, A., Ma, P., Morrissette, J., Cleveland, D., Chadwyn, D., Nigro, F., Weeks, A., Cryderman, C., Leader, R., Houde, G., Rousseau, S., Pearce, M., Radyk, M., Lonn, E., Magi, A., Lefkowitz, C., Sandrin, F., Coffin, N., Lubelsky, B., Coldwell, J., Habot, J., McPherson, C., De Larochelliere, R., Roy, M., Haichin, R., Barber, C., Bhesania, T., Kitagawa, H., To, T., Donnelly, B., Tymchak, W., Harris, L., Kouz, S., Huynh, T., St Jacques, B., Lamy, A., Rizzo, A., Stein, J., Childs, C., Wong, B., Poirier, R., Gupta, M., Dela Cruz, C., Constance, C., Gauthier, M., Ervin, F., Ouellette, M., Kokis, A., Lemay, C., Kwok, K., Leung, C., Lee, D., Nesmith, J., Renton, J., Syan, G., Turek, M., Hogan, D., Griffin, P., Lipson, A., Winestock, J., Abramson, B., Fogel, A., Gagne, C., Bergeron, J., Clarke, A., Slipp, S., Darcel, I., Carling-Chambers, L., Kannampuzha, 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Srp, V., Francek, L., Branny, M., Sknouril, L., Motovska, Z., Rohac, F., Stankova, A., Fiala, T., Holub, M., Zeman, K., Pohludkova, L., Pospisilova, E., Tuma, P., Cihalik, C., Oral, I., Podpera, I., Stepanovova, R., Uricar, M., Solar, M., Pelouch, R., Porzer, M., Grussmannova, K., Stipal, R., Reichert, P., Hradec, J., Kral, J., Sejkova, B., Janek, B., Pitha, J., Linhart, A., Polacek, P., Koeber, L., Clemmensen, P., Hebin, C.H., Schmidt, E., Pedersen, M.S., Roseva-Nielsen, N., Kristensen, K., Bang-Hansen, T., Jensen, J., Laage-Petersen, J., Nielsen, H., Stokholm, E., Thayssen, P., Cappelen, H., Jensen, T., Winther-Friis, B., Klausen, I., Hedegaard, B., May, O., Andersen, M., Bottzauw, J., Lush, A., Markenvard, J., Vestager, K.M., Bronnum-Schou, J., Hempel, H., Petersen, J., Nielsen, A.J., Thomsen, K., Nielsen, T., Nygaard, A., Sykulski, R., Jensen, B.S., Ralfkiaer, N., Gottschalck, H., Rasmussen, S., Pedersen, L.R., Dodt, K., Skovsbøl, M., Andersen, O., Tuxen, C., Meier, A.W., Kristensen, T., Rasmussen, O., Lopez, J., Salazar, D., Sanchez, L., Rosero, F., Penaherrera, E., Duarte, Y.C., Marmol, R., Andrade, G., Guzman, E., Morillo, A., Aug, L., Loogna, I., Laanmets, P., Mustonen, J., Mäntylä, P., Kesäniemi, A., Ukkola, O., Kervinen, H., Juhela, S., Juvonen, J., Toppinen, A., Jarvenpaa, J., Syvanne, M., Svahn, T., Voutilainen, S., Huotari, A., Nikkila, M., Raiskinmäki, S., Kotila, M., Rajala, A., Laukkanen, J., Hiltunen, P., Melin, J., Nyman, K., Luukkonen, J., Kosonen, P., Huttunen, M., Seppänen, V., Airaksinen, J., Juonala, M., Lehto, S., Savolainen, K., Halkosaari, M., Sia, J., Palomaki, A., Luoma, J., Utriainen, S., Valpas, S., Tiensuu, T., Lilleberg, J., Kainulainen, R., Schiele, F., Bassand, J., Meneveau, N., Galinier, M., Jean, M., Martelet, M., Mouallem, J., Elbaz, M., Puel, J., Carrié, D., Coisne, D., Varroud-Vial, N., Jaboureck, O., Dujardin, J., Leroy, F., Mansourati, J., Funck, F., Jourdain, P., Guillard, N., Coviaux, F., Gay, A., Dourmap-Collas, C., Froger-Bompas, C., Paillard, F., Tricot, O., Maquin-Mavier, I., Dubois-Rande, J.L., Pongas, D., Paris, A.P., Delahaye, F., Ovize, M., Benyahya, L., Bonnet, J., Belle, L., Mangin, L., Lafitte, B., Zemour, G., Doux, N., Agraou, B., El Mansour, N., Traisnel, G., El Jarroudi, M., Ohlmann, P., Diadema, B., Escande, M., Legros, G., Demarcq, J.M., Haftel, Y., Alsagheer, S., Dambrine, P., Cottin, Y., Ghostine, S., Caussin, C., Gacem, A., Bouvier, J.M., Poulard, J., Davy, J., Furber, A., Prunier, F., Muenzel, T., Genth-Zotz, S., Appel, K., Kretzschmar, D., Ferrari, M., Terres, W., Uher, T., Schulze, H., Ochs, H., Morbach, S., Duengen, H., Gross, M., Oezcelik, C., Tahirovic, E., Heuer, H., Laschewski, B., Kadel, C., Rahn, G., Steiner, S., Kreuzer, J., Tsoy, I., Zeiher, A., Muegge, A., Hanefeld, C., Boehm, S., Boudriot, E., Hodenberg, E., Lippe, B., Hausdorf, C., Sydow, K., Baldus, S., Schlesner, C., Tiroch, K., Haltern, G., Guelker, H., Wilhelm, J., Dietz, S., Ebelt, H., Buerke, M., Rupprecht, H., Rittgen, J., Schaeufele, T., Meinhardt, G., Schieber, M., Honold, M., Sieprath, S., Nienaber, C., Hacker, J., Butter, C., Lapp, H., Hirn, S., Pauschinger, M., Zahn, R., Scheffler, U., Schaefer, A., Schieffer, B., Tebbe, U., Kriete, M., Mudra, H., Raeder, T., Braun, P., Zeymer, U., Kouraki, K., Reppel, M., Schunkert, H., Weil, J., Olbrich, H., Schwaiger, P., Mueller, O., Blessing, E., Buss, I., Bohlscheid, V., Kaddatz, J., Skowasch, D., Nickenig, G., Twelker, K., Osterhues, H., Varghese, T., Burghard, S., Kaeaeb, S., Klauss, V., Sohn, H.Y., Hauptmann, K., Schulze, M., Gall, K., Felix, S., Doerr, M., Mante, J., Gulba, D., Freick, M., Werner, G., Kleinertz, K., Hobbach, H.P., Halbach, M., Mueller-Ehmsen, J., Mueller, M.E., Mitrovic, V., Peil, A., Laufs, U., vom Dahl, J., Baumanns, S., Scholtz, W., Wiemer, M., Haude, M., Van de Loo, A., Pistorius, K., Schaefer, J., Schwinger, R., Goeing, O., Jung, W., Birkemeyer, R., Lee, W., Kong, S., Yu, C., Chui, K., Merkely, B., Szelényi, Z., Polgár, P., Svab, S., Herczeg, B., Bajcsi, É., Vértes, A., Davidovits, S., Nagy, A., Király, C., Lupkovics, G., Kenéz, A., Poór, F., Takács, J., Kirschner, R., Simonyi, G., Koncz, J., Édes, I., Gergely, S., Katona, A., Nagy, E., Kovács, Z., Gyetvai, I., Salamon, C., Kolman, É., Sitkei, É., Csapó, K., Molnar, K., Mező, I., Sereg, M., Reddy, P., Manjunath, C., Narayanappa, S., Kumar, S., Sinha, N., Kapoor, A., Christopher, J., Reddy, G., Rani, M., Oomman, A., Ramamurthee, K., Kumar, N., Pasha, S.S., Rao, C., Murty, G.S., Chopra, A., Kapila, D., Bali, H., Chattree, K., Hasan, O., Suryaprakash, G., Rao, D., Babu, R., Bhargavi, M., Naik, S., Khan, S., Chopra, V., Sapra, R., Kaul, U., Ghose, T., Menon, R., Battikadi, S., Mullasari, A., Subban, V.K., Dani, S., Iby, M., Chandra, P., Sethi, S., Bhargava, M., Arora, P., Tyagi, G., Padmanabhan, T., Malhotra, S., Talwar, K., Shafiq, N., Kasliwal, R., Bansal, M., Eldar, M., Berger, M., Shechter, M., Atar, S., Roguin, N., Kilimnik, M., Hayek, T., Hamoud, S., Katz, A., Plaev, T., Shotan, A., Vazan, A., Weiss, A., Leibowitz, D., Zimlichman, R., Ben-Aharon, J., Hammerman, H., Dragu, R., Rozenman, Y., Witzling, V., Tzivoni, D., Moriel, M., Halkin, A., Sheps, D., Bogomolny, N., Mosseri, M., Khudyak, Y., Halabi, S., Uziel-Iunger, K., Yuval, R., Shimoni, S., Caspi, A., Botwin, S., Gavish, D., Sandler, A., Pollak, A., Kreisberg, B., Hussein, O., Jabal, K., Henkin, Y., Grosbard, A., Rosenschein, U., Rivlin, E., Zeltser, D., Platner, N., Porter, A., Harel, N., Lishner, M., Elis, A., Karny, M., Fuchs, S., Stein, G., Grossman, E., Gealel, Z., Schlaeffer, F., Liberty, I., Golik, A., Tzuman, O., De Ferrari, G., Pavesi, C., Poggio, L., Damiano, S., Pazzano, A.S., Mennuni, M., Paloscia, L., Mascellanti, M., Piovaccari, G., Grosseto, D., Mascia, F., Vetrano, A., Zingarelli, A., Mazzantini, S., Visconti, L., Terzi, G., Senni, M., Gavazzi, A., Scuri, P., Carmelo, M., De Caterina, R., Conti, M., Novo, S., Graceffa, A., Arvigo, L., Lunetta, M., Filardi, P., Chiariello, M., Scala, O., Pirozzi, E., Musella, F., Moretti, L., Testa, M., Vicentini, A., De Feo, S., Biasucci, L., Cardillo, M.T., Puccioni, E., Galli, M., Menegato, A., Margheri, M., Maresta, A., Gatti, C., Guarini, P., Damiano, M., Golino, P., Porcu, M., Fele, N., Gensini, G., Lombardi, A., Ciuti, G., Bernardi, D., Mariani, P., Paolini, E., Marenzi, G., Moltrasio, M., Terrosu, P., Chessa, P., Guglielmino, G., Miccoli, F., Oldoino, E., Ragni, M., Poli, M., Basso, V., Rapezzi, C., Branzi, A., Gallelli, I., Perna, G., Guazzarotti, F., Marra, S., Usmiani, T., Olivari, Z., Calzolari, D., Santoro, G., Minneci, C., Achilli, A., Nassiacos, D., Sommariva, L., Romeo, F., Fedele, F., Foschi, M.L., Bruno, N., Centurion, C., Patrizi, G., De Maria, E., Gonnelli, S., Vichi, V., Cassadonte, F., Rotella, G., Capucci, A., Villani, G., Gaspardone, A., Ferrante, R., Scollo, V., Pancaldi, L., Saccà, S., Gabrielli, D., Ciliberti, D., Savini, E., Binaghi, G., Di Biase, M., Ieva, R., Fattore, L., Cicia, G., Cavallini, C., Tamburino, C., Sacco, A., Mafrici, A., Di Pasquale, G., Pavesi, P.C., Scioli, R., Lioy, E., Occhiuzzi, E., Matino, M.G., Russo, V., Moscogiuri, M.G., Cuccia, C., Forgione, C., Volpe, M., Palano, F., Branca, G., Rossi, R., Modena, M., Olaru, I.A., Zanini, R., Cianflone, D., Cristell, N., Pantaleoni, M., Guiducci, U., Menozzi, C., Gaddi, O., Fasulo, A., Indolfi, C., Emanuele, V., Guerra, F., Iliceto, S., Marotta, C., Morocutti, G., Presbitero, P., Rossi, M., Bonatti, S., Grieco, A., Chiodi, L., Betti, I., Zuppiroli, A., Fanelli, R., Stanco, G., Azzolini, P., Ruggieri, C., Bocconcelli, P., Airoldi, F., Tavano, D., Brunelli, C., Caso, P., Scalzone, A., Ghigliotti, G., Facciorusso, A., Sim, K., Kiam, O., Chee, K., Bin Ismail, O., Zambahari, R., Ophuis, T., van Nes, E., Werter, C.J., Ophuis, A.J., Troquay, R.P., Hamer, B.J., Lenderink, T., Feld, R.J., van Hessen, M.W., Viergever, E.P., van der Sluis, A., Lok, D.J., Badings, E.A., Nierop, P.R., Danse, I.Y., Hermans, W.R., Holwerda, N.J., Thijssen, H.J., Theunissen, L.J., van der Zwaan, C., Van Den Berg, B.J., Hendriks, I.H., Ronner, E., Withagen, A.J., Dijkshoorn-Giesen, A.H., Ezechiels, J.P., Kuijper, A.F., Den Hartog, F.R., Van Kalmthout, P.M., Buijs, E.M., van der Zeijst, M., Zwart, P.A., Zuidgeest, J.A., van Eck, M., Daniels, M.C., van der Ven-Elzebroek, N., Van 't Hof, A., van Boven, A.J., van der Weerdt, A., Dunselman, P.H., Alings, M.A., van Es, R.F., The, S.H., Gurlek, C., Liem, A.H., van Lennep, H.W., Van Vlies, B., Kalkman, C., Swart, H.P., van der Bij, P., Taverne, R., Ciampricotti, R., van Dam, C., Spierenburg, H., van Ruijven, I., van Kempen, L.H., Willems, F.F., Dirkali, A., Stoel, I., Plomp, J., Veldmeijer, S., Tjeerdsma, G., Nijmeijer, R., Van Hal, J.M., Bartels, G.L., Posma, J.L., Linssen, G.C., Fauser, C.G., Waalewijn, R.A., Groenemeijer, B.E., Pos, L., Fast, J.H., Droste, H.T., Westenburg, J., Veenstra, W., Koolen, J., van Loo, L.W., Smits, W., Milhous, J.G., van Rossum, P., Stuij, S., Scott, R., Richards, A.M., Morrison, Z., Devlin, G., Fisher, R., Stewart, R., Benetar, J., Voss, J., Wong, S., Scott, D., Luke, R., Tang, E., Davidson, L., Hamer, A., Wilson, S., Price, R., Hart, H., Turner, A., Jortveit, J., Calic, S., Gundersen, T., Brunvand, H., Fosse, L., Nygaard, O., Gjellefall, B., Gravdal, S.A., Ringstad, R., Atar, D., Clausen, H., Hysing, J., Arvesen, K., Topper, M., Flagstad, E., Graven, T., Haug, H.H., Dalin, L., Al-Ani, R., Otterstad, J., Ausen, K., Aaser, E., Olufsen, M., Halvorsen, S., Gullestad, L., Stueflotten, W., Waage, K., Stødle, R.M., Hall, C., Aase, O., Nordeng, J., Soyland, E., Fageraas, E.R., Lied, A., Aske, R., Raouf, N., Johansson, J., Herrscher, T., Skogrand, E., Bjornstad, H., Aagnes, I., Arntsen, B.I., Vegsundvaag, J., Skjold, M.E., Velle, H., Aambakk, M.B., Skjetne, O., Byfuglien, A., Rodriguez, J., Galvez, D., Medina, F., Hernandez, H.A., Chavez, V., Morales, R., Huapalla, E., Velasquez, D., Torres, F., Aguirre, O., Yanez, L., Andrade, M., Campos, C., Arce, R., Mogrovejo, W., Osores, F., Bustamante, G., Rodriguez, M., Berrospi, P., Garcia, C., Talledo, M., Navarro, P., Horna, M., Herrera, V., Kadziela, J., Rybicka-Musialik, A., Trusz-Gluza, M., Berger-Kucza, A., Musial, W., Tycinska, A., Gil, R., Gziut, A., Gorny, J., Tyllo, M., Reszka, Z., Mickiewicz-Pawlowska, M., Wrzosek, B., Kosior, J., Staneta, P., Korzeniak, R., Kalarus, Z., Markowicz, E., Miekus, P., Konarzewski, M., Kleinrok, A., Puzniak, M., Grajek, S., Janus, M., Krzyzanowski, M., Hoffmann, A., Muzalewski, P., Polonski, L., Kazik, A., Nowalany-Kozielska, E., Wojciechowska, C., Ponikowski, P., Nawrocka, S., Filipiak, K., Serafin, A., Dubiel, J., Mielecki, W., Ogorek, M., Kopcik, D., Jaworska, K., Skonieczny, G., Kawecka-Jaszcz, K., Bryniarski, L., Tracz, W., Lesniak-Sobelga, A., Jankielewicz, J., Zaluska, R., Trojnar, R., Kawalek, P., Gaciong, Z., Pulkowski, G., Anaszewicz, M., Samul, W., Adamus, J., Cholewa, M., Kubik, L., Szczechowicz, R., Rekosz, J., Kwiatkowska, D., Gajek, J., Mazurek, W., Kominek, M., Siminiak, T., Guzniczak, E., Monteiro, P., Providencia, L., Monteiro, S., Pinho, T., Gavina, C., Sousa, C., Loureiro, J., Ferreira, A.R., Cardoso, A., Araujo, J., Rebolo, I., Catarino, C., Santos, J., Nunes, L.P., Mimoso, J., Marques, N., Leitao, M., Pais, J., Fernandes, A., Diogo, A., Nóbrega, J., Moreira, J.I., Mateus, P., Oliveira, J., Selas, M., Ribeiro, V., Albuquerque, A., Reis, R., Ramos, A., Salazar, F., Nair, D., Ng, C.K., Yeo, D., Wong, A., Funiak, S., Belicova, M., Striezova, I., Krajci, P., Sojka, G., Herman, O., Zemberova, A., Pella, D., Fedacko, J., Banikova, A., Micko, K., Macek, V., Moscovic, M., Vahala, P., Vykoukalova, T., Dzupina, A., Marusakova, M., Stevlik, J., Akubzanova, E., Hatalova, K., Burgess, L., Coetzee, C., Mabin, T., Roos, J., Mohamed, Z., Pillay, T., Corbett, C., Bodenstein, W., Tayob, F., Ebrahim, I., Bolsman, C., Horak, A., Lloyd, E., Pretorius, M., Commerford, P., De Andrade, M., Roux, J., Murray, A., Soma, P., Delport, E., Cassel, G., Van Zyl, L., Cronje, T., Sarvan, M., Moodley, R., Guerra, M., Swanepoel, N., Bayat, J., Klug, E., Hellig, S., Yoon, J., Kim, J., Chung, W., Choi, Y., Cho, M., Lee, S., Kwon, H., Hong, B., Seung, K., Chang, K., Rha, S., Jeong, M.H., Hong, Y., Lee, C., Seong, I., Jeong, J., Tahk, S., Yoon, M., Chae, S.C., Kim, H., Lopez, V., Roldan, J.M., Mancisidor, P., Froufe, J., López, A., Franco, S., Molina, A., Soriano, F., Cobos, M., Mejía, H.D., Sanz, R., Vazquez, A., Garri, F., Esteban, I., Marco, P., Artaecheverria, J., Cequier, A., Esplugas, E., Gonzalez, J., de Sa, E., Armada, E., Worner, F., Hernández, I., Roncales, F., Gomollon, J., del Rio, A., Alameda, J., Basilio, E., Rafols, M., Ferres, R., Molla, C., Pascual, J., Cortada, J., García, C., Iglesias, G., Villa, E., Aros, F., Goya, I., Bueno, M., Pereira, R.V., Clavero, X., Pasaron, C.D., Jorda, R., Pereira, R., Perez, O., de Teresa, E., Navarro, M., de la Guia, F., Lozano, T., Antorrena, I., Aranda, M., Alonso, L., Mirelis, J., Alcasena, S., Paniagua, V.A., Juanatey, J., Gregorian, L., Munoz, J., Escorihuela, A., Sanz, A., Flores, A., Garcia, P.A., Alfonso, F., Marin, E., Lozano, A., Bethencourt, A., Grau, A., Rubio, A., Sala, J., Royuela, N., San Jose, J., Bugos, V., de Valdecilla, H., Martin, J., Jimenez, R., Felgueres, M., Escalera, P., Ruiz, R., Bescos, L., Sanchez, I., Chavarri, M., Casares, G., Johanson, P., Hultsberg-Olsson, G., Witt, N., Samad, B., Damm, T., Risenfors, M., Ortgren, L., Henareh, L., Jernberg, T., Berglund, M., Karlsson, J., Koch, A., Lycksell, M., Lundgren, C., Herlitz, J., Sjölin, M., Erlinge, D., Matson, E., Cizinsky, S., Carlsson, F., Ryttberg, B., Johansson, K., Tygesen, H., Bergsten, J., Naslund, U., Sundholm, C., Timberg, I., Wikström, P., Hårdhammar, P., Lisbeth, A., Lund, L., Hage, C., Rosenqvist, U., Grändås, M., Larsson, L., Hammerman, A., Andersson, G., Johansson, S., Bennermo, M., Tjerneld, H., Forsgren, M., Eriksson, K., Eriksson, M., Bengtsson, P.O., Yu, W., Ceder-Brolin, K., Stafberg, C., Andersson, E., Roussine, V., Ångman, K., Melin, B., Thorsen, S., Lundell, L., Buijs, F., Östberg, S., Sigaud, P., Moccetti, T., Bondio, M., Kuehlkamp, V., Pieper, M., Gallino, A., Zender, H., Genné, D., Gauthey, J., Wilhelm, M., Saner, H., Trachsel, L., Roethlisberger, C., Schlaepfer, H., Kujawski, T., Pagnamenta, A., Meyer-Monard, S., Krapf, R., Biedermann, B., Schneider, H., Rickli, H., Ramsay, D., Linka, A., Ballmer, P., Oswald, M., Girod, G., Charng, M., Shu-Ling, H., Ping-Han, L., Wu, C., Liu, S., Lin, M., Chian-Yi, W., Yeh, H., Mei-Juan, C., Hsieh, I., Wang, Y., Ural, E., Sahin, T., Yildiz, Z., Kayikcioglu, M., Kultursay, H., Yigit, Z., Calpar, I., Ata, N., Goktekin, O., Senol, U., Yalcin, R., Timurkaynak, T., Kaya, U., Yildirir, A., Karacaglar, E., Faynyk, A., Sorokivskyy, M., Koval, O., Kaplan, P., Kraiz, I., Popova, K., Kyyak, Y., Barnett, O., Karpenko, O., Todoriuk, L., Tseluyko, V., Kopytsya, M., Petyunina, O., Kovalskyy, I., Zhukova, Y., Katerenchuk, I., M'yakinkova, L., Lutay, Y., Syvolap, V., Kyselov, S., Vakaliuk, I., Nesterak, R., Nikonov, V., Feskov, O., Goloborodko, B., Golovtsev, Y., Berezniakov, I., Lebedynska, M., Rudenko, L., Tutov, I., Ahsan, A., Burton, J., Levy, T., Lakeman, N., Spratt, J., Langford, E., Sutcliffe, S., Khwanda, A., Davis, G., Rodrigues, E., Dickinson, D., Been, M., Trouton, T., Riddell, J., Moriarty, A., McEneaney, D., Squire, I., Narayan, H., Goode, G., Helliwell, L., Boos, C., Greaves, K., Knops, K., Pegge, N., Signy, M., Wong, Y., Moore, S., Fluck, D., Atkinson, C., Adgey, A., McKeag, N., Bishop, A., Glover, J., Barbir, M., Breen, J., Robson, H., Townend, J., Dwenger, E., Ekpo, E., Shakespeare, C., Barr, C., McClements, B., McAllister, A., De Belder, M., Cooke, J., Williams, S., Daniel, D., Pye, M., Griffith, K., Wright, L., Trevelyan, J., Doughty, A., Hughes, E., Phillips, C., Penny, W., Groves, P., Kardos, A., Purvis, J., McNeill, A., Jones, A., Brown, J., Saeed, B., Sprigings, D., Herity, N., Brown, C., Unks, M., Cauthren, T., Bertolet, B., Jones, M., Decker, S., Chambers, J., Stahlberg, J., Varma, S., Gencheff, N., Price, A., McElroy, D., Chu, A., Crutchfield, B., Eaton, G., Looney, A., Qureshi, M., Wilks, J., Drenning, D., Overman, A., Andreou, C., Russo, P., Stuckey, T., Pruitt, H., D'Urso, M., DeRaad, R., Rogers, W., Thorington, S., Pasquini, J., Iwaoka, R., Tannenbaum, M., Prouty, D., Wiseman, A., Sharow, A., Graham, B., Ali, M.I., Dale, H., Tarsi, D., Picone, M., Juarez, S., Hamroff, G., Hollenweger, L., Scirica, B., Sabatine, M., Marti, J., Perlman, R., Pavlides, A., Joffe, I., Albirini, A., Campbell, T., Puri, S., Lopez, C., Pearce, D., Shah, D., McPherson, J., Donegan, R., Murdock, D., Block, D., Malik, A., Musina, R., Dauber, I., Varner, C., Bach, R., Palazzolo, M., Bhalla, H., Thompson, M., Pollock, S., Johnson, S., Lipson, L., Brunk, S., Karas, S., Vicari, R., Kuvin, J., Mooney, P., Aycock, G., Lane, B., Sharma, M., Gibson, T., Chang, G., DiVito, P., Mehta, R., Watkins, K., Chiu, A., Gunderson, J., Tedder, B., Williams, P., Hage-Korban, E., Childs, A., Banerjee, S., Kazi, F., Bennett, J., Barnes, D., Wohns, D., Noorman, C., Aggarwal, K., Lau-Sickman, A., Paulowski, J., Amos, M., Rider, J., Fenton, S., Schantz, M., Hakas, J., Mcsorley, J., Felten, W., Bitzer, V., Russell, J., Loyo, J., Adjei, A., Mehta, K., Uretsky, B., Hale, M., Shaikh, S., Miller, M., Hollenbaugh, D., Crawford, K., Fortuin, D., Galindo, A., Del Core, M., Butkus, E., Collins, J., Prior, J., Hahn, R., Greene-Nashold, J., Alexander, J., Genova, E., MacDonell, A., Broadwater, S., Kereiakes, D., White, D., Lopez, M., Schenks, R., Lui, H., Gibbons, P., Davis, B., Thornton, K., Daley, P., Budzon, S., McCullum, K., Delio-Cox, B., Nadar, V., Keim, S., McLaurin, B., Davis, C., Betzu, R., Al-Jumaily, J., Bolli, R., Alshaher, M., Leesar, M., Collins, T., Akkad, H., Bilazarian, S., Marsters, M., Kennett, J., Melegrito, K., Mostel, E., Harris, R., Chang, M., Hatfield, G., Makam, S., Garvey, M., Levite, H., White, J., Abdel-Latief, A., Pelletier, L., Carr, K., Mckenna, K., De Lemos, J., Soto, G., Kozina, J., Harris, D., Vlastaris, A., Bittel, B., Riba, A., Gugudis, J., Singh, N., Qureshi, I., Doty, W., Lehmann, J., Lieber, I., Martin, S., Nicu, M., Bhalodkar, N., Ravi, P., Canto, J., Bass, M., Campbell, C., Steinhubl, S., Moles, K., Harjai, K., Stapleton, D.D., Hoey, K., Erwin, J., Fikes, W., Stein, B., Sabatino, K., Teklinski, A., Colfer, H., Ward, P., Langevin, E., Faucett, S., Mamdani, S., DeSimone, L., Tuohy, E., Cullen, T., Eisenberg, S., Chronos, N., Allen, R.P., Erickson, B., Mahon, K., Kirby, A., Siegel, C., Stroud, L., Johnson, J., Panchal, V., Pearson, A., Abell, T., De Gregorio, M., Boomer, L., Vahdat, O., VanNatta, B., Long, P., Chalavarya, G., Skatrud, L., Carey, C., Wright, W., Mechem, C., Matthews, B., Adams, A., Vora, K., Wead, J., Koren, M., Gregory, D., El Khadra, M., Peacock, G., Kieval, J., Barron, M., Lewis, D., Grice, R., Bobek, M., Moore, C., Nygaard, T., Fischell, T., Salman, W., Schneider, C., Muhlestein, B., Peeler, D., Chang, D., Todd, A., Chilakamarri, V., Hanley, P., Gelormini, J., Iacona, M.A., Effron, B., Mazzurco, S., Mazzella, M., Wyman, P., Orchard, R., Battin, D., Rezkalla, S., Bishop, C., Sharp, S., Gredler, F., Knap, P., Fadel, M., Saucedo, J., Keng, A., Imburgia, M., Blank, E., Effat, M., Khoury, S., Mardis, R., Baldari, D., Tafuri, L., Mascolo, R., Taylor, D., Mandviwala, M., Khan, W., Mumford, T., Mayer, N., Mitchell, B., Oliver, T., Lombardi, W., Zimmerman, T., Rohrbeck, S., Cooke, L., Craig, M., Mego, D., Griffin, B., Perez, J., LeClerc, K., Addington, J., Aboufakher, R., Ahmed, A., Westecott, B., Steel, K., Hawkins, K., Shah, A., Ward, U., McGreevy, M., Goldberg, R., Prashad, R., McDonough, C., Silver, K., Josephson, R., Witsaman, S., Labib, S., Woodhead, G., Schrank, J., Bell, K., Chandna, H., Holly, D., Bethea, C., Fife, B., Gruberg, L., Singer, A., Ramgadoo, M., Lalonde, T., Morin, R., French, W., Barillas, O., Gradner, G., Kahn, Z., Gress, J., Rocco, D., Thew, S., Stifter, W., Fisher, M., McNamara, J., Kupfer, J., Agocha, A., Cush, S., Jones, S., Whitaker, T., Stover, T., Kumkumian, G., Kent, K., Greenberg, A., Pandey, P., Pytlewski, G., Matsumura, M., Kai, W., Sameshima, S., Thomas, J., MacNicholas, D., Pillai, K., Jones, D., Navas, J.P., Laskoe, B., Patel, P., Fini, G., Minor, S., Shipwash, T., Cabrera-Santamaria, A., Rivera, E., Mincher, L., Jafar, M., Yen, M., Finkle, C., Rahimtoola, A., Severson, L., Labroo, A., Jinich, D., Tam, K., Vogel, C., Aggarwal, R., Zakhary, B., Curtis, S., Lyster, M., Humphrey, K., Lavine, P., Fujise, K., Birnbaum, Y., Allen, J., Kesselbrenner, M., Michel, K., Staniloae, C., Liu, M., Sonel, A., Macioce-Caffas, A., Amidon, T., Leggett, J., Yedinak, S., Gudmundsson, G., Sabharwal, J., Dagefoerde, N., Wu, W., Meyerrose, G., Roongsritong, C., Jenkins, L., Lieberman, S., Sokol, S., Gutierrez, C., Nelson, C., Barrett, J., Hotchkiss, D., Farley, A., Atassi, K., Christy, L., Baig, M., Di Fazio, J., Meengs, M., Thomas, K., Surmitis, J., DeVault, S., Farhat, N., Hulyalkar, A., Riddell, L., Rivera, W., Sheynberg, B., Kobayashi, J., Katsaropoulos, J., Jan, M., Krucoff, M., Paterno, C., Chandrasekaran, S., Curry, R., Cassavar, D., Wheeler, M., McGarvey, J., Schwarz, L., Miller, E., Andrea, B., Carswell, B.S., Lurie, M., Patti, J., Bowden, W., Vasiliauskas, T., Latham, R., Schwartz, B., Bradford, L., Mattleman, S., Wertheimer, J., Goulden, D., Khan, M., Hawkins, B., Ostfeld, R., Mueller, H., Ash, Y., Wilson, V., Bayer, M., Marshall, J., Dobies, D., Dawson, G., Osman, A., Saba, F., Costello, T., Fuentes, F., Underwood, C., Vijay, N., Washam, M., Dietz, W., Glasgow, B., Mukherjee, S., Hinchion, N., Speirs, S., Thornley, A., Lee, K., Movahed, M., Strootman, D., Chernick, R., Parrott, C., Flock, C., Marques, V., Syzmanski, E., Rama, P., Domingo, D., Wu, L., Bauer, B., Dionisopoulos, P., Aggarwal, A., Holcomb, R., Foster, R., Hancock, T., Hargrove, J., Fletcher, A., Stine, R., Bullivant, M., Adams, K., Lohman, J., Klepper, V., Kabour, A., Neidhardt, J., Phillips, W., Tardiff, S., Aji, J., Corut, S., Foster, G., Firek, C., St Goar, F., Sumner, R., Davis, T., Schneider, R., Schneider, W., Villa, A., Desai, V., Chhabra, A., Banks, K., Herzog, W., Burley, T., Quyyumi, A., Smiley, W., Manocha, P., Fishbein, G., Weller, C., Coffman, A., Kim, C., Kedia, A., Firth, B., Rizvi, M., Dahiya, R., Foster, B., Balcells, E., Metzger, D.C., Lester, J., Bissett, J., Fahdi, I., Sides, E.A., Azrin, M., Martin, C., Quick, A., Conaway, D., Garg, M., Schallert, G., Lancaster, L., Mckissick, S., Atieh, M., Garbarino, J., Eisenberg, D., Uusinarkaus, K., Wirtemburg, P., Ellis, J., Cristaldi, J., Berglund, R., Negus, B., Pappas, J., Rocha, R., Nguyen, T., Stone, J., Janosik, D., Labovitz, A., Elmore, N., Dave, R., Loffredo, K., Gabriel, G., Snyder, C., Ahmed, O., Stone, H., Kelley, M., Diffenback, M., Friedman, B., Zirkle, J., Severa, L., Sample, S., Dignen, K., Raisinghani, A., Ben-Yehuda, O., Ghannadian, B., Moscoso, R., Mankowski, J., Boliek, W., Rukavina, M., Davis, W., Ledbetter, S., Handel, F., Mastouri, R., Mahenthiran, J., Foltz, J., Malhotra, V., Jonas, J., Berk, M., Singh, V., Nelson, M., Elsner, G., Gall, J., Kondo, N., Frank, S., Chandraratna, P., Ranasinghe, S., Ebrahimi, R., Treadwell, M., Walters, B., Hughes, L., Kramer, J., Kumar, K., Mente, T., Lachterman, B., Schifferdecker, B., Munshi, K., Sease, D., Waldo, D., Chandler, G., Manns, D., Nahhas, A., Kamalesh, M., Williams, V., Reich, D., Desalca, M., Sharma, S., Liston, M., Gupta, K., Costa, M., Altschuller, A., Lemmertz, K., Shanes, J., Hansen, C., Therrien, M., Mendelson, R., Ramnarine, R., Myers, G., Donovan, C., Klein, M., Fine, D., Owens, S., Murray, C., Ketroser, R., Heifetz, S., Darnell, Z., Touchon, R., Taghizadeh, B., Bohle, D., Norwood, D., Forrest, T., Jackson, S., Shumate, K., Bayles, A., Masroor, M., North, W.K., Fishberg, R., Merveil-Ceneus, B., Butcher, R., Menapace, F., Kilbride, S., Ramabadran, R.S., Loukinen, K., Khalil, J., Ramabadran, R., Walsh, S., Gill, S., Cyncar, R., McLachlan, J., Surakanti, V., Rusterholtz, L., Shoukfeh, F., Stephenson, L., Tsang, M., Nolan, V., Gilchrist, I., Jefferson, D., Feldman, T., Reyes, L., Santos, R., Little, W., Wesley, D., Gharib, W., Mendell, A., Esham, G., Kakavas, P., Whitcomb, C., Book, K., Bazzi, A., Alvarez, J., Cohen, Y., Ayres, T., Rhule, V., Labib, A., Schuler, P., Zughaib, M., Telck, K., Bikkina, M., Turnbull, K., Sharma, T., Orosz, S., Shah, R., Petrino, M., Hughes, M., Hershey, J., Hudock, D., Hui, P., Von Bakonyi, A., Arnold, A., Kappel, D., Pennock, G., Cloud, B., Tucker, K., Harp, L., Hoover, C., Eisenhauer, M., Roth, J., Young, C., Thai, H., Escalante, A., Bautista, J., Gazmuri, R., Nyland, J., Cubeddu, L., DeFranco, A., Dias, D., Fielding, M., Reeves, R., Hermany, P., Meissner-Dengler, S., Evans, M., Flores, E., Tannenbaum, A., McGarr, K., Moran, J., Stout, E., Allred, S., Henderson, D., Crandall, L., Strote, J., Voyles, W., Robeson, D., Bedoya, R., Omar, B., Pettyjohn, F., Revere, C., Coy, K., Margolis, J., Sotolongo, C., Scheffel, M., Munir, A., Shirwany, A., Douglas, L., Girala, R., Humphreys, R., Agarwal, J., Bankowski, D., Watson, R., Bishop, B., Klementowicz, P., Blais, D., Cohen, B., Lobur, E., Dimenna, J., Dempsey, K., Izzo, M., Bondi, L., Carell, E., Eaton, C., Saltiel, F., Grewal, G., Connolly, T., Little, T., Wiegman, P., Gips, S., Held, J., Paraschos, A., Quesada, R., Goudreau, E., Sears, M., Istfan, P., Holt, S., McClung, J., Nguyen, N., Quintana, O., Gottlieb, D., Knutson, T., Barringhaus, K., Lester, F., Sullivan, P., Rodriguez-Ospina, L., Cannon, C.P., Blazing, M.A., Giugliano, R.P., McCagg, A., White, J.A., Lewis, B.S., Jukema, J.W., De Lucca, P., Im, K., Bohula, E.A., Reist, C., Wiviott, S.D., Tershakovec, A.M., Musliner, T.A., Braunwald, E., and Califf, R.M.
- Abstract
Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years. The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P=0.016). Rates of prespecified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benef
- Published
- 2015
11. Primary reperfusion in acute myocardial infection with ReoPro and heparin: interim results of ReoMI pilot study
- Author
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Makkar, R., primary, Eigler, N., additional, Goff, B., additional, Fry, E., additional, Barr, L., additional, D'Haem, C., additional, Fischell, T., additional, and Litvack, F., additional
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- 1998
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12. Radiation dose from a phosphorous-32 impregnated wire mesh vascular stent
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Janicki, C., primary, Duggan, D. M., additional, Coffey, C. W., additional, Fischell, D. R., additional, and Fischell, T. A., additional
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- 1997
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13. Low-dose, beta-particle emission from 'stent' wire results in complete, localized inhibition of smooth muscle cell proliferation.
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Fischell, T A, primary, Kharma, B K, additional, Fischell, D R, additional, Loges, P G, additional, Coffey, C W, additional, Duggan, D M, additional, and Naftilan, A J, additional
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- 1994
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- View/download PDF
14. Effect of L-arginine on coronary endothelial function in cardiac transplant recipients. Relation to vessel wall morphology.
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Drexler, H, primary, Fischell, T A, additional, Pinto, F J, additional, Chenzbraun, A, additional, Botas, J, additional, Cooke, J P, additional, and Alderman, E L, additional
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- 1994
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- View/download PDF
15. Immediate and one-year safety of intracoronary ultrasonic imaging. Evaluation with serial quantitative angiography.
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Pinto, F J, primary, St Goar, F G, additional, Gao, S Z, additional, Chenzbraun, A, additional, Fischell, T A, additional, Alderman, E L, additional, Schroeder, J S, additional, and Popp, R L, additional
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- 1993
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16. Nitroglycerin-induced coronary vasodilation in cardiac transplant recipients. Evaluation with in vivo intracoronary ultrasound.
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Pinto, F J, primary, St Goar, F G, additional, Fischell, T A, additional, Stadius, M L, additional, Valantine, H A, additional, Alderman, E L, additional, and Popp, R L, additional
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- 1992
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- View/download PDF
17. Ultrasonic energy. Effects on vascular function and integrity.
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Fischell, T A, primary, Abbas, M A, additional, Grant, G W, additional, and Siegel, R J, additional
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- 1991
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- View/download PDF
18. Roles of thrombin and platelet membrane glycoprotein IIb/IIIa in platelet-subendothelial deposition after angioplasty in an ex vivo whole artery model.
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Kaplan, A V, primary, Leung, L L, additional, Leung, W H, additional, Grant, G W, additional, McDougall, I R, additional, and Fischell, T A, additional
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- 1991
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- View/download PDF
19. Determinants of smooth muscle injury during balloon angioplasty.
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Fischell, T A, primary, Grant, G, additional, and Johnson, D E, additional
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- 1990
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- View/download PDF
20. Evidence for altered epicardial coronary artery autoregulation as a cause of distal coronary vasoconstriction after successful percutaneous transluminal coronary angioplasty.
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Fischell, T A, primary, Bausback, K N, additional, and McDonald, T V, additional
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- 1990
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- View/download PDF
21. Analysis of 1-year clinical outcomes in the SIRIUS trial: a randomized trial of a sirolimus-eluting stent versus a standard stent in patients at high risk for coronary restenosis.
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Holmes DR Jr., Leon MB, Moses JW, Popma JJ, Cutlip D, Fitzgerald PJ, Brown C, Fischell T, Wong SC, Midei M, Snead D, and Kuntz RE
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- 2004
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- View/download PDF
22. Safety of an aspirin-alone regimen after intracoronary stenting with a heparin-coated stent: final results of the HOPE (HEPACOAT and an antithrombotic regimen of aspirin alone) study.
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Mehran R, Aymong ED, Ashby DT, Fischell T, Whitworth H Jr., Siegel R, Thomas W, Wong SC, Narasimaiah R, Lansky AJ, and Leon MB
- Published
- 2003
23. Failure of a novel balloon-expandable gamma-emitting ((103)Pd) stent to prevent edge effects.
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Hehrlein, C, DeVries, J J, Arab, A, Haller, S D, Schloesser, K, Tio, F O, and Fischell, T A
- Published
- 2001
24. Dose and dose rate effects of beta-particle emitting radioactive stents in a porcine model of restenosis
- Author
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Carter, A. J., Jenkins, S., Sweet, W., Bailey, L., Jones, R., Fischell, T. A., and Virmani, R.
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- 1999
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- View/download PDF
25. Current Status of Radioactive Stents for the Prevention of In-Stent Restenosis
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Carter, A. J. and Fischell, T. A.
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- 1998
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- View/download PDF
26. The Beta-Particle-Emitting Radioisotope Stent (Isostent): Animal Studies and Planned Clinical Trials
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Fischell, T. A., Carter, A. J., and Laird, J. R.
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- 1996
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- View/download PDF
27. A system for postoperative visualization and analysis of left ventricular pressure volume loops
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Beard, B. B., Stewart, J. R., and Fischell, T. A.
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- 1998
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- View/download PDF
28. Transesophageal two-dimensional echocardiography and color Doppler flow velocity mapping in the evaluation of cardiac valve prostheses.
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Nellessen, U, primary, Schnittger, I, additional, Appleton, C P, additional, Masuyama, T, additional, Bolger, A, additional, Fischell, T A, additional, Tye, T, additional, and Popp, R L, additional
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- 1988
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29. Endothelium-dependent arterial vasoconstriction after balloon angioplasty.
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Fischell, T A, primary, Nellessen, U, additional, Johnson, D E, additional, and Ginsburg, R, additional
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- 1989
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- View/download PDF
30. Chronic stimulation via percutaneously inserted epidural electrodes
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North, R B, primary, Fischell, T A, additional, and Long, D M, additional
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- 1977
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31. Coronary artery vasoconstriction routinely occurs after percutaneous transluminal coronary angioplasty. A quantitative arteriographic analysis.
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Fischell, T A, primary, Derby, G, additional, Tse, T M, additional, and Stadius, M L, additional
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- 1988
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- View/download PDF
32. Quantitative angiographic outcome after intracoronary pullback atherectomy.
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Kwok, On-Hing, Prpic, Ross, Kinlay, Scott, Giri, Satyendra, Popma, Jeffrey, Fischell, Tim, Kwok, O H, Prpic, R, Kinlay, S, Giri, S, Popma, J, and Fischell, T
- Subjects
- *
ANGIOGRAPHY , *ENDARTERECTOMY - Abstract
Discusses the quantitative angiographic outcome after intracoronary pullback atherectomy. Study design and population; Acute procedural success rate; Angiographic evidence of dissection or spasm; Relation of various factors to major angiographic complications after pullback atherectomy.
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- 2001
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33. Roles of thrombin and platelet membrane glycoprotein IIb/IIIa in platelet-subendothelial deposition after angioplasty in an ex vivo whole artery model
- Author
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Fischell, T [Department of Medicine, Stanford University School of Medicine, CA (United States)]
- Published
- 1991
- Full Text
- View/download PDF
34. Management of Atrial Fibrillation Post Transcatheter Aortic Valve Implantation.
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Banga S, Abela GS, Saltiel F, Fischell T, Kalavakunta JK, Sood A, Jolly G, Najib K, Al-Ali H, Qintar M, Bazil J, Singh Y, and Gupta V
- Subjects
- Humans, Treatment Outcome, Risk Factors, Aortic Valve surgery, Transcatheter Aortic Valve Replacement adverse effects, Atrial Fibrillation drug therapy, Aortic Valve Stenosis complications, Stroke epidemiology, Stroke etiology, Stroke prevention & control
- Abstract
Atrial fibrillation (AF) is a common complication in patients who underwent transcatheter aortic valve implantation. Some of these patients have preexisting AF as well. The management of these patients is complex, especially after the procedure, when there is a sudden change in hemodynamics. There are no established guidelines about the management of the patients who underwent transcatheter aortic valve replacement with preexisting or new-onset AF. This review article discusses the management of these patients with rate and rhythm control strategies with medications. This article also highlights the role of newer oral anticoagulation medications and left atrial occlusion devices to prevent stroke after the procedure. We will also discuss new advances in the care of this patient population to prevent the occurrence of AF after transcatheter aortic valve implantation. In conclusion, this article is a synopsis of both pharmacologic and device interventions for the management of AF in patients who underwent transcatheter aortic valve replacement., Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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35. Shockwave Lithotripsy of Calcific Stenosis of the Distal Abdominal Aorta to Facilitate Transcatheter Aortic Valve Replacement.
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Ponna PK, Gonuguntla A, Botta RK, Fischell T, and Agrawal Y
- Subjects
- Humans, Aorta, Abdominal diagnostic imaging, Aorta, Abdominal surgery, Constriction, Pathologic surgery, Aortic Valve diagnostic imaging, Aortic Valve surgery, Treatment Outcome, Risk Factors, Transcatheter Aortic Valve Replacement adverse effects, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Calcinosis diagnostic imaging, Calcinosis surgery, Lithotripsy
- Abstract
The transfemoral approach for transcatheter aortic valve replacement (TAVR) is superior to alternative access strategies. Only transfemoral access has been shown to have better clinical outcomes than surgical aortic valve replacement. In our patient, severe calcification of the distal abdominal aorta posed difficulty in using transfemoral access for TAVR. We applied intravascular lithotripsy (IVL) to the distal abdominal aorta to achieve necessary luminal gain facilitating bioprosthetic aortic valve deployment., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
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- View/download PDF
36. Evaluation of Transcatheter Alcohol-Mediated Perivascular Renal Denervation to Treat Resistant Hypertension.
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Janas A, Król M, Hochuł M, Jochymczyk M, Hayward-Costa C, Parise H, Haratani N, Fischell T, and Wojakowski W
- Abstract
Catheter-based renal denervation (RDN) has been investigated for hypertension (HTN) treatment with variable success. One of the novel approaches to RDN is the delivery of micro-doses of dehydrated alcohol to the adventitial space of the renal artery to perform perivascular ablation of the sympathetic nerves. We sought to assess the safety and efficiency of transcatheter alcohol-mediated perivascular renal denervation in patients with resistant hypertension. Fifty adult patients who had been referred for resistant HTN were screened. To qualify for the study, the patients had to have a mean 24 h systolic pressure ≥ 135 mmHg based upon ambulatory blood pressure monitoring (ABPM) and acceptable renal artery anatomy confirmed by the contrast computer tomography (AngioCT) and nephrologist consultation. Ten patients were eligible for chemical RND. There were no safety issues throughout the 24 months of follow-ups. The mean decrease in the office BP (OBP) was significant during 24 months of follow-up ( p < 0.01). The difference in the BP in the ABPM was statistically significant in the 1st, 3rd and 12th months ( p < 0.01), whereas during the 3-month follow-up, a trend was observed. The modifications of anti-hypertension drugs throughout the follow-up period were minimal. This study has shown that transcatheter alcohol-mediated renal denervation in patients with resistant hypertension is feasible and safe. Nevertheless, it is a hypothesis-generating study.
- Published
- 2020
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37. Implanted Monitor Alerting to Reduce Treatment Delay in Patients With Acute Coronary Syndrome Events.
- Author
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Holmes DR Jr, Krucoff MW, Mullin C, Mikdadi G, Presser D, Wohns D, Kaplan A, Ciuffo A, Eberly AL 3rd, Iteld B, Fischell DR, Fischell T, Keenan D, John MS, and Gibson CM
- Subjects
- Adult, Aged, Emergency Service, Hospital, False Positive Reactions, Female, Hospitalization, Humans, Male, Middle Aged, Monitoring, Physiologic instrumentation, Monitoring, Physiologic methods, Non-ST Elevated Myocardial Infarction diagnosis, Non-ST Elevated Myocardial Infarction therapy, Prospective Studies, Risk, ST Elevation Myocardial Infarction diagnosis, ST Elevation Myocardial Infarction therapy, Treatment Outcome, Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome therapy, Clinical Alarms, Time-to-Treatment
- Abstract
Background: Increased pre-hospital delay during acute coronary syndrome (ACS) events contributes to worse outcome., Objectives: The purpose of this study was to assess the effectiveness of an implanted cardiac monitor with real-time alarms for abnormal ST-segment shifts to reduce pre-hospital delay during ACS events., Methods: In the ALERTS (AngeLmed Early Recognition and Treatment of STEMI) pivotal study, subjects at high risk for recurrent ACS events (n = 907) were randomized to control (Alarms OFF) or treatment groups for 6 months, after which alarms were activated in all subjects (Alarms ON). Emergency department (ED) visits with standard-of-care cardiac test results were independently adjudicated as true- or false-positive ACS events. Alarm-to-door (A2D) and symptom-to-door (S2D) times were calculated for true-positive ACS ED visits triggered by 3 possible prompts: alarm only, alarms + symptoms, or symptoms only., Results: The Alarms ON group showed reduced delays, with 55% (95% confidence interval [CI]: 46% to 63%) of ED visits for ACS events <2 h compared with 10% (95% CI: 2% to 27%) in the Alarms OFF group (p < 0.0001). Results were similar when restricted to myocardial infarction (MI) events. Median pre-hospital delay for MI was 12.7 h for Alarms OFF and 1.6 h in Alarms ON subjects (p < 0.0089). Median A2D delay was 1.4 h for asymptomatic MI. Median S2D delay for symptoms-only MI (no alarm) in Alarms ON was 4.3 h., Conclusions: Intracardiac monitoring with real-time alarms for ST-segment shift that exceeds a subject's self-normative ischemia threshold level significantly reduced the proportion of pre-hospital delays >2 h for ACS events, including asymptomatic MI, compared with symptoms-only ED visits in Alarms OFF. (AngeLmed for Early Recognition and Treatment of STEMI [ALERTS]; NCT00781118)., (Copyright © 2019. Published by Elsevier Inc.)
- Published
- 2019
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38. Eptifibatide: The evidence for its role in the management of acute coronary syndromes.
- Author
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Shah I, Khan SO, Malhotra S, and Fischell T
- Abstract
Introduction: Acute coronary syndromes and non-Q-wave myocardial infarction are often initiated by platelet activation. Eptifibatide is a cyclic heptapeptide and is the third inhibitor of glycoprotein (Gp) IIb/IIIa that has found broad acceptance after the specific antibody abciximab and the nonpeptide tirofiban entered the global market. Gp IIb/IIIa inhibitors act by inhibiting the final common pathway of platelet aggregation, and play an important role in the management of acute coronary syndromes., Aims: This review assesses the evidence for therapeutic value of eptifibatide as a Gp IIb/IIIa inhibitor in patients with acute coronary syndromes., Evidence Review: Several large, randomized controlled trials show that eptifibatide as adjunctive therapy to standard care in patients with non-ST segment elevation acute coronary syndrome is associated with a significant reduction in the incidence of death or myocardial infarction. Data are limited regarding the use of eptifibatide in patients with ST segment elevation myocardial infarction. Cost-effectiveness analysis indicates that eptifibatide is associated with a favorable cost-effectiveness ratio relative to standard care. According to US cost-effectiveness analysis about 70% of the acquisition costs of eptifibatide are offset by the reduced medical resource consumption during the first year. Eptifibatide was well tolerated in most of the trials. Bleeding is the most commonly reported adverse event, with most major bleeding episodes occurring at the vascular access site. Major intracranial bleeds, stroke, or profound thrombocytopenia rarely occurred during eptifibatide treatment., Place in Therapy: Eptifibatide has gained widespread acceptance as an adjunct to standard anticoagulation therapy in patients with acute coronary syndromes, and may be particularly useful in the management of patients with elevated troponin or undergoing percutaneous coronary interventions.
- Published
- 2010
- Full Text
- View/download PDF
39. Coronary embolization following balloon dilation of lipid-core plaques.
- Author
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Goldstein JA, Grines C, Fischell T, Virmani R, Rizik D, Muller J, and Dixon SR
- Subjects
- Aged, Angioplasty, Balloon, Coronary instrumentation, Autopsy, Coronary Angiography, Coronary Stenosis diagnosis, Coronary Stenosis metabolism, Death, Sudden, Cardiac pathology, Electrocardiography, Embolism diagnosis, Embolism metabolism, Fatal Outcome, Female, Humans, Male, Middle Aged, Myocardial Infarction diagnosis, Myocardial Infarction metabolism, No-Reflow Phenomenon etiology, No-Reflow Phenomenon metabolism, Severity of Illness Index, Spectroscopy, Near-Infrared, Stents, Treatment Outcome, Angioplasty, Balloon, Coronary adverse effects, Coronary Stenosis therapy, Death, Sudden, Cardiac etiology, Embolism etiology, Lipids analysis, Myocardial Infarction etiology
- Published
- 2009
- Full Text
- View/download PDF
40. Sirolimus-eluting stents for treatment of complex bypass graft disease: insights from the SECURE registry.
- Author
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Costa M, Angiolillo DJ, Teirstein P, Gilmore P, Leon M, Moses J, Yakubov S, Carter A, Fischell T, Zenni M, and Bass T
- Subjects
- Angioplasty, Balloon, Coronary statistics & numerical data, Coronary Angiography, Coronary Restenosis diagnostic imaging, Coronary Restenosis etiology, Coronary Stenosis diagnostic imaging, Coronary Stenosis surgery, Female, Follow-Up Studies, Humans, Male, Middle Aged, Treatment Outcome, United States, Angioplasty, Balloon, Coronary instrumentation, Coated Materials, Biocompatible, Coronary Artery Bypass adverse effects, Coronary Restenosis therapy, Immunosuppressive Agents therapeutic use, Registries, Sirolimus therapeutic use, Stents
- Abstract
Unlabelled: Graft disease remains a therapeutic challenge. Procedural complications and unsatisfactory patency rates are realized with both percutaneous intervention and repeat coronary artery bypass graft (CABG) surgery. The efficacy of sirolimus-eluting stents (SES) for the treatment of de novo coronary artery disease has been established, but the use of this technology to treat bypass graft disease remains undefined. The aim of this study was to evaluate the safety and feasibility of SES to treat patients with high-risk bypass graft disease., Methods: The compassionate use of SES (SECURE) study included patients with recurrent coronary disease and no acceptable alternative available treatment, including brachytherapy or CABG. Outcomes from 76 patients (n = 94 lesions) with graft lesions treated with SES in the U.S. were compared with the outcomes of 176 patients (n = 311 lesions) with only native vessels. IVUS follow-up was performed at 8 months in 14 patients with graft SES treatment., Results: In-hospital outcomes were similar between both groups, with 99% of patients discharged without adverse events. The incidence of target vessel failure including death, MI, and TVR at 12 months in the bypass graft group (55.3%) was similar to that observed in the native vessel group (45.5%, p = 0.17). Intimal hyperplasia (IH) measured by IVUS was 11.8 +/- 16.5%; 50% of patients with graft SES had < 1% IH at 8 months., Conclusion: Implantation of SES in high-risk patients with recurrent bypass graft disease is feasible. SES represents a future.
- Published
- 2005
41. Intragraft nicardipine prophylaxis to prevent no-reflow in triple-vessel saphenous vein graft intervention.
- Author
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Fischell T, Haller S, and Ashraf K
- Subjects
- Aged, Aged, 80 and over, Coronary Artery Disease therapy, Humans, Male, Angioplasty, Balloon, Coronary adverse effects, Coronary Artery Bypass methods, Coronary Artery Disease drug therapy, Graft Occlusion, Vascular prevention & control, Myocardial Reperfusion methods, Nicardipine therapeutic use, Saphenous Vein transplantation, Stents, Vasodilator Agents therapeutic use
- Published
- 2005
42. IAGS proceedings. The biology of plaque and patient vulnerability. Panel discussion.
- Author
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Lerman A, Vogel J, Fischell T, Leimgruber P, and Firth B
- Subjects
- Cholesterol blood, Coronary Artery Disease physiopathology, Endothelium, Vascular pathology, Humans, Myocardial Infarction etiology, Myocardial Ischemia therapy, Risk Factors, Stress, Physiological physiopathology, Coronary Vessels pathology, Myocardial Ischemia physiopathology
- Published
- 2005
43. Intracoronary brachytherapy in the porcine model: a different animal.
- Author
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Fischell TA and Virmani R
- Subjects
- Angioplasty, Balloon, Coronary adverse effects, Animals, Clinical Trials as Topic, Coronary Restenosis etiology, Coronary Thrombosis etiology, Coronary Vessels radiation effects, Humans, Rabbits, Swine, Wound Healing, Brachytherapy, Coronary Restenosis radiotherapy, Disease Models, Animal
- Published
- 2001
44. Overestimation of stent delivery balloon diameters by manufacturers' compliance tables: a quantitative coronary analysis of Duet and NIR stent implantation.
- Author
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Hehrlein C, DeVries JJ, Wood TA, Haller SD, Arab A, Kloostra AC, Lauer MA, and Fischell TA
- Subjects
- Angioplasty, Balloon, Coronary statistics & numerical data, Calcium physiology, Evaluation Studies as Topic, Female, Humans, Male, Observer Variation, Prosthesis Implantation, Reproducibility of Results, Statistics as Topic, Time Factors, Coronary Disease therapy, Coronary Vessels surgery, Stents
- Abstract
Although manufacturers' compliance tables of stent delivery balloons indicate the diameter of the balloon at a given inflation pressure, it is unclear whether these data correlate with in vivo true intracoronary balloon diameters (TBDs). The TBDs of two new-generation balloon-expandable stent delivery systems (Duet and NIR) were measured by quantitative coronary analysis (QCA) in 100 consecutive patients. The manufacturers' stated balloon diameter (BD) of the stent delivery systems overestimated the TBD in 94% +/- 4% of patients receiving both Duet or NIR stent implantations. In only 6% of the patients, the TBD matched the manufacturers' stated balloon diameter. There was no underestimation of TBDs by both manufacturers' compliance tables. The Duet tables overestimated TBDs by 14% +/- 8% (range, 1%-36%), the NIR tables by 18% +/- 8% (range, 1%-41%), P < 0.05, Duet vs. NIR, respectively. When the manufacturers' data were corrected for the differences in reporting data from in vitro tests, i.e., balloon compliance data with or without the stent, the degree of overestimation of diameters was similar for Duet and NIR stent delivery balloons (14% +/- 8% vs. 13% +/- 7%, Duet vs. NIR; P = NS). Manufacturers' compliance tables of both the Duet and NIR stent delivery balloon systems significantly overestimate the true intracoronary balloon diameter. The manufacturers' of stent delivery balloons should clearly state on the box, if balloon compliance data were derived from in vitro bench testing, which phantoms were used for compliance analysis, and that the tables may overestimate the true intracoronary balloon diameter. The findings of the present study have important clinical implications with respect to performing coronary stent implantation with precision., (Copyright 2001 Wiley-Liss, Inc.)
- Published
- 2001
- Full Text
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45. Visible stents: all that glitters...is it gold?
- Author
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Fischell TA
- Subjects
- Angioplasty, Balloon, Coronary methods, Biocompatible Materials, Equipment Design, Female, Humans, Male, Sensitivity and Specificity, Angioplasty, Balloon, Coronary instrumentation, Coronary Disease therapy, Gold, Stents
- Published
- 2000
46. Ultrasound thrombolysis for the treatment of thrombotic occlusion of degenerated saphenous vein grafts.
- Author
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Fischell TA, Haddad N, Baskerville S, and Foster MT
- Subjects
- Coronary Angiography, Coronary Artery Bypass methods, Coronary Disease diagnostic imaging, Female, Follow-Up Studies, Graft Occlusion, Vascular diagnostic imaging, Graft Survival, Humans, Male, Middle Aged, Saphenous Vein transplantation, Thrombosis diagnostic imaging, Treatment Outcome, Coronary Artery Bypass adverse effects, Coronary Disease surgery, Graft Occlusion, Vascular therapy, Saphenous Vein pathology, Thrombosis therapy, Ultrasonic Therapy
- Abstract
Despite improvements in catheter-based revascularization outcomes, coronary interventionalists face difficult challenges in the treatment of the thrombus-laden coronary lesion. In this report, we describe the use of the Acolysis device, which utilizes high-frequency (41.9 kHz) ultrasonic energy to vibrate a small metal tip at the end of a 4.5 Fr catheter to treat two thrombotically occluded saphenous vein grafts in two patients. In both cases, the Acolysis device provided normalization of flow with angiographically evident dissolution of thrombus and excellent acute angiographic and clinical results. We conclude that in these two selected cases the Acolysis device was used safely and effectively for thrombus debulking as an adjunct to stenting in diseased saphenous vein bypass grafts.
- Published
- 2000
- Full Text
- View/download PDF
47. The impact of stent design and delivery upon the long-term efficacy of radioisotope stents.
- Author
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Fischell TA, Hehrlein C, Fischell RE, and Fischell DR
- Subjects
- Coronary Angiography, Dose-Response Relationship, Radiation, Equipment Design, Feasibility Studies, Humans, Phosphorus Radioisotopes administration & dosage, Radiotherapy Dosage, Recurrence, Brachytherapy instrumentation, Coronary Disease radiotherapy, Stents
- Abstract
Both gamma and beta irradiation delivered via a radioactive catheter-based line source have been shown to have efficacy in reducing restenosis. However, these catheter-based treatments have some limitations, including the safety of handling sources ranging from 30 mCi to 500 mCi. Alternatively, one could use a stent as the platform for local radiation delivery as a means to prevent restenosis. Experimental studies have demonstrated that stents ion implanted with the b-particle emitter 32P can reduce neointima formation. Clinical evaluation of the radioisotope stent began in the fall of 1996. Dose escalation studies have now been completed in approximately 250 patients with 32P, b-particle emitting stents ranging from 0.5 microCi to 24 microCi. Overall, these feasibility trials have demonstrated a clear, dose-dependent reduction of neointimal hyperplasia within the stent structure, but with an unanticipated finding of a relatively high incidence of restenosis at the stent margins. The purpose of this paper is to review the current status of radioactive stents, with an emphasis on the key elements of stent design and stent delivery that could impact the long-term efficacy of this device.
- Published
- 2000
48. Effect of glycoprotein IIb/IIIa inhibition without thrombolytic therapy on reperfusion in acute myocardial infarction: results of ReoMI pilot study.
- Author
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Makkar R, Goff B, Eigler N, Sebastian M, Fischell T, Barr L, D'Haem C, Shah PK, Effron MB, and Litvack F
- Subjects
- Abciximab, Adult, Aged, Female, Humans, Male, Middle Aged, Myocardial Infarction drug therapy, Pilot Projects, Prospective Studies, Angioplasty, Balloon, Coronary, Antibodies, Monoclonal therapeutic use, Anticoagulants therapeutic use, Heparin therapeutic use, Immunoglobulin Fab Fragments therapeutic use, Myocardial Infarction therapy, Platelet Glycoprotein GPIIb-IIIa Complex antagonists & inhibitors
- Abstract
The efficacy of abciximab and moderate dose heparin in attaining reperfusion in acute MI was tested in a multicenter pilot study. Patients with acute MI of less than 6-hr onset triaged to primary PTCA received intravenous abciximab bolus and infusion and heparin (70 u/kg) in the emergency room. Mean time to angiography from administration of abciximab was 34 +/- 23 min. TIMI flow rates were: grade 0-62%, grade I-20%, grade II-9%, and grade III-9%. Primary PTCA was performed with 100% success rate. Access site bleeding occurred in 10% of patients with no incidence of intracranial bleeding. TIMI II/III flow rates were 50% in a patient subset where angiography was delayed by 45 min. While not an alternative to thrombolytics in AMI, abciximab administration in the emergency room in patients triaged to PTCA may be beneficial in situation where door to needle time is delayed as TIMI II/III flows may be attained in some patients. Cathet. Cardiovasc. Intervent. 48:430-434, 1999., (Copyright 1999 Wiley-Liss, Inc.)
- Published
- 1999
- Full Text
- View/download PDF
49. Cleaning up the mess: new approaches to the old problem of thrombus in coronary interventions.
- Author
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Fischell TA
- Subjects
- Animals, Humans, Sodium Chloride administration & dosage, Sodium Chloride therapeutic use, Thrombectomy instrumentation, Angioplasty, Balloon, Coronary adverse effects, Coronary Thrombosis etiology, Coronary Thrombosis therapy, Thrombectomy methods
- Published
- 1999
50. Adenosine for reversal of "no reflow".
- Author
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Fischell TA and Foster MT 3rd
- Subjects
- Coronary Artery Bypass, Humans, Vascular Patency, Adenosine administration & dosage, Cardiovascular Agents administration & dosage, Coronary Vessels physiology, Stents
- Published
- 1999
- Full Text
- View/download PDF
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