99 results on '"Figliozzi S."'
Search Results
2. Myocardial Fibrosis at Cardiac MRI Helps Predict Adverse Clinical Outcome in Patients with Mitral Valve Prolapse
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Figliozzi, S, Georgiopoulos, G, Lopes, P, Bauer, K, Moura-Ferreira, S, Tondi, L, Mushtaq, S, Censi, S, Pavon, A, Bassi, I, Servato, M, Teske, A, Biondi, F, Filomena, D, Pica, S, Torlasco, C, Muraru, D, Monney, P, Quattrocchi, G, Maestrini, V, Agati, L, Monti, L, Pedrotti, P, Vandenberk, B, Squeri, A, Lombardi, M, Ferreira, A, Schwitter, J, Aquaro, G, Chiribiri, A, Rodríguez Palomares, J, Yilmaz, A, Andreini, D, Florian, A, Leiner, T, Abecasis, J, Badano, L, Bogaert, J, Masci, P, Figliozzi, Stefano, Georgiopoulos, Georgios, Lopes, Pedro M, Bauer, Klemens B, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Servato, Maria Luz, Teske, Arco J, Biondi, Federico, Filomena, Domenico, Pica, Silvia, Torlasco, Camilla, Muraru, Denisa, Monney, Pierre, Quattrocchi, Giuseppina, Maestrini, Viviana, Agati, Luciano, Monti, Lorenzo, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Ferreira, António M, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Rodríguez Palomares, José F, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Leiner, Tim, Abecasis, João, Badano, Luigi, Bogaert, Jan, Masci, Pier-Giorgio, Figliozzi, S, Georgiopoulos, G, Lopes, P, Bauer, K, Moura-Ferreira, S, Tondi, L, Mushtaq, S, Censi, S, Pavon, A, Bassi, I, Servato, M, Teske, A, Biondi, F, Filomena, D, Pica, S, Torlasco, C, Muraru, D, Monney, P, Quattrocchi, G, Maestrini, V, Agati, L, Monti, L, Pedrotti, P, Vandenberk, B, Squeri, A, Lombardi, M, Ferreira, A, Schwitter, J, Aquaro, G, Chiribiri, A, Rodríguez Palomares, J, Yilmaz, A, Andreini, D, Florian, A, Leiner, T, Abecasis, J, Badano, L, Bogaert, J, Masci, P, Figliozzi, Stefano, Georgiopoulos, Georgios, Lopes, Pedro M, Bauer, Klemens B, Moura-Ferreira, Sara, Tondi, Lara, Mushtaq, Saima, Censi, Stefano, Pavon, Anna Giulia, Bassi, Ilaria, Servato, Maria Luz, Teske, Arco J, Biondi, Federico, Filomena, Domenico, Pica, Silvia, Torlasco, Camilla, Muraru, Denisa, Monney, Pierre, Quattrocchi, Giuseppina, Maestrini, Viviana, Agati, Luciano, Monti, Lorenzo, Pedrotti, Patrizia, Vandenberk, Bert, Squeri, Angelo, Lombardi, Massimo, Ferreira, António M, Schwitter, Juerg, Aquaro, Giovanni Donato, Chiribiri, Amedeo, Rodríguez Palomares, José F, Yilmaz, Ali, Andreini, Daniele, Florian, Anca, Leiner, Tim, Abecasis, João, Badano, Luigi, Bogaert, Jan, and Masci, Pier-Giorgio
- Abstract
Background: Patients with mitral valve prolapse (MVP) may develop adverse outcomes even in the absence of mitral regurgitation or left ventricular (LV) dysfunction. Purpose: To investigate the prognostic value of mitral annulus disjunction (MAD) and myocardial fibrosis at late gadolinium enhancement (LGE) cardiac MRI in patients with MVP without moderate-to-severe mitral regurgitation or LV dysfunction. Materials and Methods: In this longitudinal retrospective study, 118 144 cardiac MRI studies were evaluated between October 2007 and June 2020 at 15 European tertiary medical centers. Follow-up was from the date of cardiac MRI examination to June 2020; the minimum and maximum follow-up intervals were 6 months and 156 months, respectively. Patients were excluded if at least one of the following conditions was present: cardiomyopathy, LV ejection fraction less than 40%, ischemic heart disease, congenital heart disease, inflammatory heart disease, moderate or worse mitral regurgitation, participation in competitive sport, or electrocardiogram suggestive of channelopathies. In the remainder, cardiac MRI studies were reanalyzed, and patients were included if they were aged 18 years or older, MVP was diagnosed at cardiac MRI, and clinical information and electrocardiogram monitoring were available within 3 months from cardiac MRI examination. The end point was a composite of adverse outcomes: sustained ventricular tachycardia (VT), sudden cardiac death (SCD), or unexplained syncope. Multivariable Cox regression analysis was performed. Results: A total of 474 patients (mean age, 47 years ± 16 [SD]; 244 women) were included. Over a median follow-up of 3.3 years, 18 patients (4%) reached the study end point. LGE presence (hazard ratio, 4.2 [95% CI: 1.5, 11.9]; P = .006) and extent (hazard ratio, 1.2 per 1% increase [95% CI: 1.1, 1.4]; P = .006), but not MAD presence (P = .89), were associated with clinical outcome. LGE presence had incremental prognostic value over MVP severi
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- 2023
3. Cardiac magnetic resonance feature-tracking analysis of left atrial volumes and function in standard vs left-atrial focused images
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Tondi, L, primary, Figliozzi, S, additional, Badano, L P, additional, Torlasco, C, additional, Disabato, G, additional, Pica, S, additional, Camporeale, A, additional, Muraru, D, additional, and Lombardi, M, additional
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- 2022
- Full Text
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4. Unlocking the Mysteries of Arrhythmic Mitral Valve Prolapse by CMR Imaging: Is There a Tricuspid Annulus Disjunction?
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Muraru, D, Figliozzi, S, Muraru D., Figliozzi S., Muraru, D, Figliozzi, S, Muraru D., and Figliozzi S.
- Published
- 2021
5. Recent advances in multimodality imaging of the tricuspid valve
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Caravita, S, Figliozzi, S, Florescu, D, Volpato, V, Oliverio, G, Tomaselli, M, Torlasco, C, Muscogiuri, G, Cernigliaro, F, Parati, G, Badano, L, Muraru, D, Caravita S., Figliozzi S., Florescu D. -R., Volpato V., Oliverio G., Tomaselli M., Torlasco C., Muscogiuri G., Cernigliaro F., Parati G., Badano L., Muraru D., Caravita, S, Figliozzi, S, Florescu, D, Volpato, V, Oliverio, G, Tomaselli, M, Torlasco, C, Muscogiuri, G, Cernigliaro, F, Parati, G, Badano, L, Muraru, D, Caravita S., Figliozzi S., Florescu D. -R., Volpato V., Oliverio G., Tomaselli M., Torlasco C., Muscogiuri G., Cernigliaro F., Parati G., Badano L., and Muraru D.
- Abstract
Introduction: The tricuspid valve (TV) and the right heart chambers are complex three-dimensional structures that are difficult to assess using tomographic imaging techniques. The progressive aging of the general population and the advancements in treating left-sided heart diseases by transcatheter procedures have contributed to the tricuspid regurgitation (TR) becoming a major public health problem associated with progression to refractory heart failure and poor outcome. Recent advances in multimodality cardiac imaging allow a better understanding of the pathophysiology of TR that may translate in better management of patients. Areas covered: Three-dimensional echocardiography, cardiac magnetic resonance, and computed tomography provide complementary information to i. assess the TV complex; ii. identify the etiology and the mechanisms of TR; iii. evaluate its severity and hemodynamic consequences; iv. explore the remodeling of the right heart chambers; and v. properly plan, guide, and monitor the transcatheter interventions aimed to reduce the severity of TR. Expert opinion: We need thorough understanding of both the TV and the right heart chamber geometry and function to understand the pathophysiology of TR. The integrated use of multimodality cardiac imaging is pivotal to assess patients with TR and to identify tailored and timely treatment of TR in properly selected patients.
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- 2021
6. Multimodality cardiac imaging and new display options to broaden our understanding of the tricuspid valve
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Volpato, V, Badano, L, Figliozzi, S, Florescu, D, Parati, G, Muraru, D, Volpato V., Badano L., Figliozzi S., Florescu D. R., Parati G., Muraru D., Volpato, V, Badano, L, Figliozzi, S, Florescu, D, Parati, G, Muraru, D, Volpato V., Badano L., Figliozzi S., Florescu D. R., Parati G., and Muraru D.
- Abstract
Purpose of review The prognostic impact of tricuspid regurgitation (TR) and the subsequent development of percutaneous procedures targeting the tricuspid valve (TV), has brought to the forefront the role of imaging for the assessment of the forgotten valve. As illustrated in several studies and summarized in this review, currently a multimodality imaging approach is required to understand the pathophysiology of TR, due to the complex TV anatomy and the close relationship between the severity of TR and the extent of the remodeling of the right heart chambers.Recent findingsRecently, the advance in the tranhscatheter treatment of the TV has led to a growing interest in the development of dedicated software packages and new display modalities to increase our understanding of the TV. As a consequence, a transversal knowledge of the different imaging modalities is required for contemporary cardiac-imaging physicians.SummaryThis review highlights the main features, and the pros and cons of echocardiography, cardiac computed tomography, cardiac magnetic resonance and emerging technologies, as 3D printing and virtual reality, in the assessment of patients with TR.
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- 2021
7. ECG-based score estimates the probability to detect Fabry Disease cardiac involvement
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Figliozzi, S, Camporeale, A, Boveri, S, Pieruzzi, F, Pieroni, M, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Graziani, F, Pica, S, Tondi, L, Bernardini, A, Chow, K, Namdar, M, Lombardi, M, Figliozzi S., Camporeale A., Boveri S., Pieruzzi F., Pieroni M., Lusardi P., Spada M., Mignani R., Burlina A., Graziani F., Pica S., Tondi L., Bernardini A., Chow K., Namdar M., Lombardi M., Figliozzi, S, Camporeale, A, Boveri, S, Pieruzzi, F, Pieroni, M, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Graziani, F, Pica, S, Tondi, L, Bernardini, A, Chow, K, Namdar, M, Lombardi, M, Figliozzi S., Camporeale A., Boveri S., Pieruzzi F., Pieroni M., Lusardi P., Spada M., Mignani R., Burlina A., Graziani F., Pica S., Tondi L., Bernardini A., Chow K., Namdar M., and Lombardi M.
- Abstract
Objectives: To elaborate an ECG-based nomogram estimating the probability to detect cardiac involvement by cardiac magnetic resonance (CMR) in Fabry Disease (FD). Methods: 119 FD patients and 26 healthy controls underwent ECG and CMR. Test (n = 88, 60%) and validation cohorts (n = 57, 40%) were randomly derived. Cardiac involvement was defined as the presence of low myocardial T1 value, a CMR-surrogate of myocardial glycosphingolipid storage. ECG changes associated with low T1 value were identified in the test cohort, included in the nomogram and then tested in the validation cohort. Results: Sokolow-Lyon index (AUC = 0.769), ratio between P-wave and PR-segment durations (Pwave/PRsegment) (AUC = 0.778), QRS duration (AUC = 0.703), QT (AUC = 0.769) duration were independently associated with the presence of low T1 on CMR at multivariate analysis. An ECG-based nomogram including these four parameters was accurate in identifying patients with CMR evidence of glycosphingolipid storage (c-index of the derived-nomogram = 0.90 in the test group; 0.81 in the validation group). Conclusion: We propose a practical ECG-based nomogram accurately estimating the probability to detect low T1 values by CMR in FD patients. The application of this tool in clinical practice could improve early detection of FD cardiac involvement.
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- 2021
8. Atrial Dysfunction Assessed by Cardiac Magnetic Resonance as an Early Marker of Fabry Cardiomyopathy
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Bernardini, A, Camporeale, A, Pieroni, M, Pieruzzi, F, Figliozzi, S, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Carubbi, F, Battaglia, Y, Graziani, F, Pica, S, Tondi, L, Chow, K, Boveri, S, Olivotto, I, Lombardi, M, Bernardini A., Camporeale A., Pieroni M., Pieruzzi F., Figliozzi S., Lusardi P., Spada M., Mignani R., Burlina A., Carubbi F., Battaglia Y., Graziani F., Pica S., Tondi L., Chow K., Boveri S., Olivotto I., Lombardi M., Bernardini, A, Camporeale, A, Pieroni, M, Pieruzzi, F, Figliozzi, S, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Carubbi, F, Battaglia, Y, Graziani, F, Pica, S, Tondi, L, Chow, K, Boveri, S, Olivotto, I, Lombardi, M, Bernardini A., Camporeale A., Pieroni M., Pieruzzi F., Figliozzi S., Lusardi P., Spada M., Mignani R., Burlina A., Carubbi F., Battaglia Y., Graziani F., Pica S., Tondi L., Chow K., Boveri S., Olivotto I., and Lombardi M.
- Published
- 2020
9. Effective Study: Development and Application of a Question-Driven, Time-Effective Cardiac Magnetic Resonance Scanning Protocol
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Torlasco, C, Castelletti, S, Soranna, D, Volpato, V, Figliozzi, S, Menacho, K, Cernigliaro, F, Zambon, A, Kellman, P, Moon, J, Badano, L, Parati, G, Torlasco, Camilla, Castelletti, Silvia, Soranna, Davide, Volpato, Valentina, Figliozzi, Stefano, Menacho, Katia, Cernigliaro, Franco, Zambon, Antonella, Kellman, Peter, Moon, James C, Badano, Luigi, Parati, Gianfranco, Torlasco, C, Castelletti, S, Soranna, D, Volpato, V, Figliozzi, S, Menacho, K, Cernigliaro, F, Zambon, A, Kellman, P, Moon, J, Badano, L, Parati, G, Torlasco, Camilla, Castelletti, Silvia, Soranna, Davide, Volpato, Valentina, Figliozzi, Stefano, Menacho, Katia, Cernigliaro, Franco, Zambon, Antonella, Kellman, Peter, Moon, James C, Badano, Luigi, and Parati, Gianfranco
- Abstract
BACKGROUND: Long scanning times impede cardiac magnetic resonance (CMR) clinical uptake. A “one-size-fits-all” shortened, focused protocol (eg, only function and late-gadolinium enhancement) reduces scanning time and costs, but provides less information. We developed 2 question-driven CMR and stress-CMR protocols, including tailored advanced tissue characterization, and tested their effectiveness in reducing scanning time while retaining the diagnostic performances of standard protocols. METHODS AND RESULTS: Eighty three consecutive patients with cardiomyopathy or ischemic heart disease underwent the tailored CMR. Each scan consisted of standard cines, late-gadolinium enhancement imaging, native T1-mapping, and extracellular volume. Fat/edema modules, right ventricle cine, and in-line quantitative perfusion mapping were performed as clinically required. Workflow was optimized to avoid gaps. Time target was <30 minutes for a CMR and [removed]30% (CMR: from 42±8 to 28±6 minutes; stress-CMR: from 50±10 to 34±6 minutes, both P[removed]45% of cases. Quality grading was similar between the 2 protocols. Tailored protocols did not require additional staff. CONCLUSIONS: Tailored CMR and stress-CMR protocols including advanced tissue characterization are accurate and timeeffective for cardiomyopathies and ischemic heart disease.
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- 2022
10. Unlocking the Mysteries of Arrhythmic Mitral Valve Prolapse by CMR Imaging: Is There a Tricuspid Annulus Disjunction?
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Muraru D., Figliozzi S., Muraru, D, and Figliozzi, S
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annulus disjunction ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,tricuspid valve prolapse ,mitral valve prolapse ,cardiac magnetic resonance ,sudden cardiac death - Published
- 2021
11. Current clinical applications of three-dimensional echocardiography
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Badano, L, Aruta, P, Nguyen, K, Palermo, C, Baritussio, A, Cecchetto, A, Previtero, M, Figliozzi, S, Genovese, D, Guta, A, Ochoa-Jimenez, R, Parati, G, Muraru, D, Badano L., Aruta P., Nguyen K., Palermo C., Baritussio A., Cecchetto A., Previtero M., Figliozzi S., Genovese D., Guta A. C., Ochoa-Jimenez R. C., Parati G., Muraru D., Badano, L, Aruta, P, Nguyen, K, Palermo, C, Baritussio, A, Cecchetto, A, Previtero, M, Figliozzi, S, Genovese, D, Guta, A, Ochoa-Jimenez, R, Parati, G, Muraru, D, Badano L., Aruta P., Nguyen K., Palermo C., Baritussio A., Cecchetto A., Previtero M., Figliozzi S., Genovese D., Guta A. C., Ochoa-Jimenez R. C., Parati G., and Muraru D.
- Abstract
Three-dimensional echocardiography (3DE) represents one of the most innovative advances in cardiovascular imaging over the last 20 years. Recent technological developments have fueled the full implementation of 3DE in clinical practice and expanded its impact on patient diagnosis, management, and prognosis. One of the most important clinical applications of transthoracic 3DE has been the quantitation of cardiac chamber volumes and function. The main limitations affecting two-dimensional echocardiography calculations of chamber volumes (i.e. geometric assumptions about cardiac chamber shape and view foreshortening) are overcome by 3DE that allows an actual measurement of their volumes. Transesophageal 3DE has been applied mainly to assess the anatomy and function of heart valves, congenital defects and masses in the beating heart. As reparative cardiac surgery and transcatheter procedures have become more and more popular to treat structural heart disease, transesophageal 3DE has become not only one of the main imaging modalities for procedure planning but also for intra-procedural guidance and assessment of procedural results. New image rendering modalities such as 3D printing, holographic display, and fusion of 3DE images with other radiological or nuclear modalities will further expand the clinical applications and indications of 3DE.
- Published
- 2019
12. Late gadolinium enhancement predicts adverse clinical outcome in patients with mitral valve prolapse/mitral annulus disjunction
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Figliozzi, S, primary, Georgiopoulos, G, additional, Aquaro, GD, additional, Bauer, K, additional, Monti, L, additional, Filomena, D, additional, Pica, S, additional, Censi, S, additional, Lopez, P, additional, Quattrocchi, G, additional, Servato, ML, additional, Schwitter, J, additional, Andreini, D, additional, Bogaert, J, additional, and Masci, PG, additional
- Published
- 2021
- Full Text
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13. Echocardiography versus computed tomography and cardiac magnetic resonance for the detection of left heart thrombosis: a systematic review and meta-analysis
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Aimo, A. Kollia, E. Ntritsos, G. Barison, A. Masci, P.-G. Figliozzi, S. Klettas, D. Stamatelopoulos, K. Delialis, D. Emdin, M. Georgiopoulos, G.
- Abstract
Background: Accurate and reproducible diagnostic techniques are essential to detect left-sided cardiac thrombi [either in the left ventricle (LV) or in the left atrial appendage (LAA)] and to guide the onset and duration of antithrombotic treatment while minimizing the risk for thromboembolic and hemorrhagic events. Methods: We conducted a systematic review and meta-analysis aiming to compare the diagnostic performance of transthoracic echocardiography (TTE) vs. cardiac magnetic resonance (CMR) for the detection of LV thrombi, and transesophageal echocardiography (TEE) vs. computed tomography (CT) for the detection of LAA thrombi. Results: Six studies were included in the first meta-analysis (TTE vs. CMR for LV thrombosis). Pooled sensitivity and specificity values were 62% [95% confidence interval (CI), 37–81%] and 97% (95% CI, 94–99%). The shape of the hierarchical summary receiver operating characteristic (HSROC) curve and the area under the curve (AUC) of 0.96 suggested a high accuracy. Ten studies were included in the second meta-analysis (CT versus TEE for LAA thrombosis). The pooled values of sensitivity and specificity were 97% (95% CI, 77–100%) and 94% (95% CI, 87–98%). The pooled diagnostic odds ratio (DOR) was 500 (95% CI, 52–4810), and the pooled likelihood ratios (LR + and LR−) were 17% (95% CI, 7–40%) and 3% (95% CI, 0–28%). The shape of the HSROC curve and 0.99 AUC suggested a high accuracy of CT vs. TEE. Conclusions: TTE is a fair alternative to DE-CMR for the identification of LV thrombi, while CT has a good accuracy compared to TEE for the detection of LAA thrombosis. PROSPERO registration: CRD42020185842. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
- Published
- 2021
14. Prognostic Impact of Late Gadolinium Enhancement by Cardiovascular Magnetic Resonance in Myocarditis: A Systematic Review and Meta-Analysis
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Georgiopoulos, G. Figliozzi, S. Sanguineti, F. Aquaro, G.D. Di Bella, G. Stamatelopoulos, K. Chiribiri, A. Garot, J. Masci, P.G. Ismail, T.F.
- Abstract
Background: Patients with acute myocarditis (AM) are at increased risk of adverse cardiac events after the index episode. Late gadolinium enhancement (LGE) detected by cardiovascular magnetic resonance in patients with AM plays an important diagnostic role, but its prognostic significance remains unresolved. This systematic review and meta-analysis sought to assess the prognostic implications of cardiovascular magnetic resonance-derived LGE in patients with AM. Methods: Data search was conducted from inception through February 28, 2020, using the following Medical Subject Heading terms: Myocarditis, CMR, Magnetic Resonance Imaging, Magnetic Resonance. From 2422 articles retrieved, we selected 11 studies reporting baseline cardiovascular magnetic resonance assessment and long-term clinical follow-up in patients with AM. Hazard ratios and CIs for a combined clinical end point were recorded for LGE presence, extent (>2 segments or >10% of left ventricular [LV] mass or >17g) and location (anteroseptal versus non-anteroseptal). A combined end point comprised all-cause mortality, cardiac mortality, and major adverse cardiovascular events. Hartung and Knapp correction improved robustness of the results. Prespecified sensitivity analyses explored potential sources of heterogeneity. The meta-analysis was conducted according to the Meta-analysis of Observational Studies in Epidemiology guidelines. Results: LGE presence (pooled hazard ratios, 3.28 [95% CIs, 1.69-6.39], P
- Published
- 2021
15. Atrial functional tricuspid regurgitation: A novel and underappreciated clinical entity
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Florescu, D, Figliozzi, S, Guta, A, Vicini, S, Tomaselli, M, Târtea, G, Istrătoaie, O, Parati, G, Badano, L, Muraru, D, Florescu, Diana-Ruxandra, Figliozzi, Stefano, Guta, Andrada, Vicini, Stefano, Tomaselli, Michele, Târtea, Georgică Costinel, Istrătoaie, Octavian, Parati, Gianfranco, Badano, Luigi, Muraru, Denisa, Florescu, D, Figliozzi, S, Guta, A, Vicini, S, Tomaselli, M, Târtea, G, Istrătoaie, O, Parati, G, Badano, L, Muraru, D, Florescu, Diana-Ruxandra, Figliozzi, Stefano, Guta, Andrada, Vicini, Stefano, Tomaselli, Michele, Târtea, Georgică Costinel, Istrătoaie, Octavian, Parati, Gianfranco, Badano, Luigi, and Muraru, Denisa
- Abstract
Functional or secondary tricuspid regurgitation (FTR) is a progressive disease with a significant negative impact on patient morbidity and mortality. Recently, atrial fibrillation (AF) has been recognized as a cause of FTR (with/without coexisting functional mitral regurgitation) by promoting right atrial (RA) remodeling and secondary tricuspid valve (TV) annulus dilation, even in the absence of right ventricular (RV) dilation or dysfunction. This distinct form of FTR has been called “atriogenic” or “atrial”. Recent evidence suggests that the RA is an important player in FTR pathophysiology not only for patients with AF, but also for those in sinus rhythm. Preliminary reports on atrial FTR show that cardioversion with documented maintenance of sinus rhythm promotes TV annulus and RA reverse remodeling and may significantly reduce FTR severity at follow-up. Large-scale studies on the prognostic benefits of rhythm vs rate-control strategy in atrial FTR patients are needed to substantiate specific guidelines indications for this subset of patients.
- Published
- 2021
16. Prognostic validation of partition values for quantitative parameters to grade functional tricuspid regurgitation severity by conventional echocardiography
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Muraru, D, Previtero, M, Ochoa-Jimenez, R, Guta, A, Figliozzi, S, Gregori, D, Bottigliengo, D, Parati, G, Badano, L, Muraru, Denisa, Previtero, Marco, Ochoa-Jimenez, Roberto C, Guta, Andrada C, Figliozzi, Stefano, Gregori, Dario, Bottigliengo, Daniele, Parati, Gianfranco, Badano, Luigi, Muraru, D, Previtero, M, Ochoa-Jimenez, R, Guta, A, Figliozzi, S, Gregori, D, Bottigliengo, D, Parati, G, Badano, L, Muraru, Denisa, Previtero, Marco, Ochoa-Jimenez, Roberto C, Guta, Andrada C, Figliozzi, Stefano, Gregori, Dario, Bottigliengo, Daniele, Parati, Gianfranco, and Badano, Luigi
- Abstract
Quantitative echocardiography parameters are seldom used to grade tricuspid regurgitation (TR) severity due to relative paucity of validation studies and lack of prognostic data. To assess the relationship between TR severity and the composite endpoint of death and hospitalization for congestive heart failure (CHF); and to identify the threshold values of vena contracta width (VCavg), effective regurgitant orifice area (EROA), regurgitant volume (RegVol), and regurgitant fraction (RegFr) to define low, intermediate, and high-risk TR based on patients' outcome data.
- Published
- 2021
17. Poster session Thursday 12 December - PM: 12/12/2013, 14: 00–18: 00Location: Poster area
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Tarzia, P, Villano, A, Figliozzi, S, Russo, G, Parrinello, R, Lamendola, P, Sestito, A, Lanza, GA, and Crea, F
- Published
- 2013
18. Multi-Modality Imaging in Dilated Cardiomyopathy: With a Focus on the Role of Cardiac Magnetic Resonance
- Author
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Mitropoulou, P. Georgiopoulos, G. Figliozzi, S. Klettas, D. Nicoli, F. Masci, P.G.
- Subjects
cardiovascular system ,cardiovascular diseases - Abstract
Heart failure (HF) is recognized as a leading cause of morbidity and mortality worldwide. Dilated cardiomyopathy (DCM) is a common phenotype in patients presenting with HF. Timely diagnosis, appropriate identification of the underlying cause, individualized risk stratification, and prediction of clinical response to treatment have improved the prognosis of DCM over the last few decades. In this article, we reviewed the current evidence on available imaging techniques used for DCM patients. In this direction, we evaluated appropriate scenarios for the implementation of echocardiography, nuclear imaging, and cardiac computed tomography, and we focused on the primordial role that cardiac magnetic resonance (CMR) holds in the diagnosis, prognosis, and tailoring of therapeutic options in this population of special clinical interest. We explored the predictive value of CMR toward left ventricular reverse remodeling and prediction of sudden cardiac death, thus guiding the decisions for device therapy. Principles underpinning the use of state-of-the-art CMR techniques such as parametric mapping and feature-tracking strain analysis are also provided, along with expectations for the anticipated future advances in this field. We also attempted to correlate the evidence with clinical practice, with the intent to address questions on selecting the optimal imaging method for different indications and clinical needs. Overall, we recommend a comprehensive assessment of DCM patients at baseline and at follow-up intervals depending on the clinical status, with the addition of CMR as a second-line modality to other imaging techniques. We also provide an algorithm to guide the detailed imaging approach of the patient with DCM. We expect that future guidelines will upgrade their clinical recommendations for the utilization of CMR in DCM, which is expected to further improve the quality of care and the outcomes. This review provides an up-to-date perspective on the imaging of dilated cardiomyopathy patients and will be of clinical value to training doctors and physicians involved in the area of heart failure. © Copyright © 2020 Mitropoulou, Georgiopoulos, Figliozzi, Klettas, Nicoli and Masci.
- Published
- 2020
19. Predictors of adverse prognosis in COVID-19: A systematic review and meta-analysis
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Figliozzi, S. Masci, P.G. Ahmadi, N. Tondi, L. Koutli, E. Aimo, A. Stamatelopoulos, K. Dimopoulos, M.-A. Caforio, A.L.P. Georgiopoulos, G.
- Abstract
Background: Identification of reliable outcome predictors in coronavirus disease 2019 (COVID-19) is of paramount importance for improving patient's management. Methods: A systematic review of literature was conducted until 24 April 2020. From 6843 articles, 49 studies were selected for a pooled assessment; cumulative statistics for age and sex were retrieved in 587 790 and 602 234 cases. Two endpoints were defined: (a) a composite outcome including death, severe presentation, hospitalization in the intensive care unit (ICU) and/or mechanical ventilation; and (b) in-hospital mortality. We extracted numeric data on patients’ characteristics and cases with adverse outcomes and employed inverse variance random-effects models to derive pooled estimates. Results: We identified 18 and 12 factors associated with the composite endpoint and death, respectively. Among those, a history of CVD (odds ratio (OR) = 3.15, 95% confidence intervals (CIs) 2.26-4.41), acute cardiac (OR = 10.58, 5.00-22.40) or kidney (OR = 5.13, 1.78-14.83) injury, increased procalcitonin (OR = 4.8, 2.034-11.31) or D-dimer (OR = 3.7, 1.74-7.89), and thrombocytopenia (OR = 6.23, 1.031-37.67) conveyed the highest odds for the adverse composite endpoint. Advanced age, male sex, cardiovascular comorbidities, acute cardiac or kidney injury, lymphocytopenia and D-dimer conferred an increased risk of in-hospital death. With respect to the treatment of the acute phase, therapy with steroids was associated with the adverse composite endpoint (OR = 3.61, 95% CI 1.934-6.73), but not with mortality. Conclusions: Advanced age, comorbidities, abnormal inflammatory and organ injury circulating biomarkers captured patients with an adverse clinical outcome. Clinical history and laboratory profile may then help identify patients with a higher risk of in-hospital mortality. © 2020 Stichting European Society for Clinical Investigation Journal Foundation
- Published
- 2020
20. Increased remote extracellular volume measured by CMR T1 mapping allows early identification of left atrial dysfunction in hypertrophic cardiomyopathy
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Tondi, L, primary, Pica, S, additional, Camporeale, A, additional, Figliozzi, S, additional, Bernardini, A, additional, Pluchinotta, F, additional, Secchi, F, additional, and Lombardi, M, additional
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- 2020
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- View/download PDF
21. Progressive electrocardiographic changes in parallel with cardiac magnetic resonance findings in fabry disease
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Figliozzi, S, primary, Camporeale, A, additional, Pieroni, M, additional, Pieruzzi, F, additional, Namdar, M, additional, Lusardi, P, additional, Spada, M, additional, Mignani, R, additional, Burlina, A, additional, Scolari, F, additional, Carrubbi, F, additional, Battaglia, Y, additional, Graziani, F, additional, Boveri, S, additional, and Lombardi, M, additional
- Published
- 2020
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- View/download PDF
22. 47 Identification of threshold values to define right chamber enlargement consistent with severe tricuspid regurgitation
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Previtero, M, primary, Bottigliengo, D, additional, Guta, A C, additional, Ochoa-Jimenez, R C, additional, Figliozzi, S, additional, Palermo, C, additional, Baritussio, A, additional, Cecchetto, A, additional, Aruta, P, additional, Iliceto, S, additional, Badano, L P, additional, and Muraru, D, additional
- Published
- 2020
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- View/download PDF
23. P764 Right ventricular basal diameter, but not volume, can predict severe tricuspid regurgitation
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Previtero, M, primary, Guta, A C, additional, Ochoa-Jimenez, R C, additional, Palermo, C, additional, Bottigliengo, D, additional, Figliozzi, S, additional, Baritussio, A, additional, Cecchetto, A, additional, Aruta, P, additional, Iliceto, S, additional, Badano, L P, additional, and Muraru, D, additional
- Published
- 2020
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- View/download PDF
24. 38 Prognostic validation of partition values obtained with conventional two-dimensional and doppler echocardiography to grade tricuspid regurgitation severity
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Previtero, M, primary, Guta, A C, additional, Ochoa-Jimenez, R C, additional, Figliozzi, S, additional, Palermo, C, additional, Baritussio, A, additional, Cecchetto, A, additional, Aruta, P, additional, Iliceto, S, additional, Badano, L P, additional, and Muraru, D, additional
- Published
- 2020
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- View/download PDF
25. Percutaneous closure of a very wide interatrial septal defect: clinical case and literature review
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Figliozzi, S, D'Amico, G, Fraccaro, C, Napodano, M, and Tarantini, G
- Subjects
Amplatzer Septal Occluder ,Atrial septal defect ,Percutaneous closure - Published
- 2018
26. 222A rare congenital valve abnormality unexpectedly detected in a patient with aortic dissection
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Figliozzi, S, primary, Baritussio, A, additional, Alderighi, C, additional, Ruozi, N, additional, Aruta, P, additional, Badano, L P, additional, De Conti, G, additional, Perazzolo Marra, M, additional, Aliberti, C, additional, and Iliceto, S, additional
- Published
- 2019
- Full Text
- View/download PDF
27. P359A very unusual cause of exercise-induced ventricular arrhythmias in the athlete
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Figliozzi, S, primary, Cipriani, A, additional, Zorzi, A, additional, Andres, A L, additional, Aliberti, C, additional, Iliceto, S, additional, Corrado, D, additional, Rigato, I, additional, Perazzolo Marra, M, additional, and Bauce, B, additional
- Published
- 2019
- Full Text
- View/download PDF
28. Endothelial and platelet function in children with previous Kawasaki disease
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Laurito, Marianna, Stazi, Alessandra, Delogu, Angelica Bibiana, Milo, Maria, Battipaglia, Irma, Scalone, Giancarla, Infusino, Fabio, Villano, Angelo, Russo, Giulio, Iannotta, Rossella, Saracino, A, Parrinello, R, Figliozzi, S, Sestito, Alfonso, Romagnoli, Costantino, Lanza, Gaetano Antonio, Crea, Filippo, Delogu, Angelica Bibiana (ORCID:0000-0002-2283-3180), Sestito, Alfonso (ORCID:0000-0001-9965-2997), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), Lanza, Gaetano Antonio (ORCID:0000-0003-2187-6653), Crea, Filippo (ORCID:0000-0001-9404-8846), Laurito, Marianna, Stazi, Alessandra, Delogu, Angelica Bibiana, Milo, Maria, Battipaglia, Irma, Scalone, Giancarla, Infusino, Fabio, Villano, Angelo, Russo, Giulio, Iannotta, Rossella, Saracino, A, Parrinello, R, Figliozzi, S, Sestito, Alfonso, Romagnoli, Costantino, Lanza, Gaetano Antonio, Crea, Filippo, Delogu, Angelica Bibiana (ORCID:0000-0002-2283-3180), Sestito, Alfonso (ORCID:0000-0001-9965-2997), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), Lanza, Gaetano Antonio (ORCID:0000-0003-2187-6653), and Crea, Filippo (ORCID:0000-0001-9404-8846)
- Abstract
We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P < .001). In conclusion, children with a previous episode of KD showed increased platelet activation, compared with healthy participants despite no apparent vascular abnormality at follow-up.
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- 2014
29. Endothelial and Platelet Function in Children With Previous Kawasaki Disease
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Laurito, Marianna, Stazi, Alessandra, Delogu, Angelica Bibiana, Milo, Maria, Battipaglia, Irma, Scalone, Giancarla, Infusino, Fabio, Villano, Angelo, Russo, Giulio, Iannotta, R, Saracino, A, Parrinello, R, Figliozzi, S, Sestito, Alfonso, Romagnoli, Costantino, Lanza, Gaetano Antonio, Crea, Filippo, Delogu, Angelica Bibiana (ORCID:0000-0002-2283-3180), Sestito, Alfonso (ORCID:0000-0001-9965-2997), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), Lanza, Gaetano Antonio (ORCID:0000-0003-2187-6653), Crea, Filippo (ORCID:0000-0001-9404-8846), Laurito, Marianna, Stazi, Alessandra, Delogu, Angelica Bibiana, Milo, Maria, Battipaglia, Irma, Scalone, Giancarla, Infusino, Fabio, Villano, Angelo, Russo, Giulio, Iannotta, R, Saracino, A, Parrinello, R, Figliozzi, S, Sestito, Alfonso, Romagnoli, Costantino, Lanza, Gaetano Antonio, Crea, Filippo, Delogu, Angelica Bibiana (ORCID:0000-0002-2283-3180), Sestito, Alfonso (ORCID:0000-0001-9965-2997), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), Lanza, Gaetano Antonio (ORCID:0000-0003-2187-6653), and Crea, Filippo (ORCID:0000-0001-9404-8846)
- Abstract
We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P < .001). In conclusion, children with a previous episode of KD showed increased platelet activation, compared with healthy participants despite no apparent vascular abnormality at follow-up.
- Published
- 2013
30. Endothelial and Platelet Function in Children With Previous Kawasaki Disease
- Author
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Laurito, M, Stazi, A, Delogu, Angelica Bibiana, Milo, M, Battipaglia, I, Scalone, G, Infusino, F, Villano, A, Russo, G, Iannotta, R, Saracino, A, Parrinello, R, Figliozzi, S, Sestito, A, Romagnoli, Costantino, Lanza, Ga, Crea, F., Delogu, Angelica Bibiana (ORCID:0000-0002-2283-3180), Romagnoli, Costantino (ORCID:0000-0003-1176-2943), Laurito, M, Stazi, A, Delogu, Angelica Bibiana, Milo, M, Battipaglia, I, Scalone, G, Infusino, F, Villano, A, Russo, G, Iannotta, R, Saracino, A, Parrinello, R, Figliozzi, S, Sestito, A, Romagnoli, Costantino, Lanza, Ga, Crea, F., Delogu, Angelica Bibiana (ORCID:0000-0002-2283-3180), and Romagnoli, Costantino (ORCID:0000-0003-1176-2943)
- Abstract
We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P < .001). In conclusion, children with a previous episode of KD showed increased platelet activation, compared with healthy participants despite no apparent vascular abnormality at follow-up.
- Published
- 2013
31. Peripheral and coronary vascular function in patients with variant angina
- Author
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Parrinello, R., primary, Villano, A., additional, Russo, G., additional, Di Franco, A., additional, Tarzia, P., additional, Nerla, R., additional, Figliozzi, S., additional, Sestito, A., additional, Lanza, G. A., additional, and Crea, F., additional
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- 2013
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32. Long term effects of bariatric surgery on peripheral endothelial function and on coronary microvascular function
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Tarzia, P., primary, Villano, A., additional, Figliozzi, S., additional, Russo, G., additional, Parrinello, R., additional, Lamendola, P., additional, Sestito, A., additional, Lanza, G. A., additional, and Crea, F., additional
- Published
- 2013
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33. P359 A very unusual cause of exercise-induced ventricular arrhythmias in the athlete.
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Figliozzi, S, Cipriani, A, Zorzi, A, Andres, A L, Aliberti, C, Iliceto, S, Corrado, D, Rigato, I, Marra, M Perazzolo, and Bauce, B
- Subjects
VENTRICULAR arrhythmia ,ATHLETES ,CONFERENCES & conventions ,EXERCISE ,DISEASE risk factors - Published
- 2019
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- View/download PDF
34. 222 A rare congenital valve abnormality unexpectedly detected in a patient with aortic dissection.
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Figliozzi, S, Baritussio, A, Alderighi, C, Ruozi, N, Aruta, P, Badano, L P, Conti, G De, Marra, M Perazzolo, Aliberti, C, and Iliceto, S
- Subjects
HEART valve abnormalities ,CONFERENCES & conventions ,AORTIC dissection ,MITRAL valve diseases - Published
- 2019
- Full Text
- View/download PDF
35. Poster session Thursday 12 December - PM: 12/12/2013, 14:00-18:00 * Location: Poster area
- Author
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Garcia Martin, A, Fernandez Golfin, C, Salido Tahoces, L, Fernandez Santos, S, Jimenez Nacher, JJ, Moya Mur, JL, Velasco Valdazo, E, Hernandez Antolin, R, Zamorano Gomez, JL, Veronesi, F, Corsi, C, Caiani, EG, Lamberti, C, Tsang, W, Holmgren, C, Guo, X, Bateman, M, Iaizzo, P, Vannier, M, Lang, RM, Patel, AR, Adamayn, KG, Tumasyan, L R, Chilingaryan, AL, Nasr, G, Eleraki, A, Farouk, N, Axelsson, A, Langhoff, L, Jensen, MK, Vejlstrup, N, Iversen, K, Bundgaard, H, Watanabe, T, Iwai-Takano, M, Attenhofer Jost, C H, Pfyffer, M, Seifert, B, Scharf, C, Candinas, R, Medeiros-Domingo, A, Chin, J-Y, Yoon, HJ, Vollbon, W, Singbal, Y, Rhodes, K, Wahi, S, Katova, T M, Simova, I I, Hristova, K, Kostova, V, Pauncheva, B, Bircan, A, Sade, LE, Eroglu, S, Pirat, B, Okyay, K, Bal, U, Muderrisoglu, H, Heggemann, F, Buggisch, H, Welzel, G, Doesch, C, Hansmann, J, Schoenberg, S, Borggrefe, M, Wenz, F, Papavassiliu, T, Lohr, F, Roussin, I, Drakopoulou, M, Rosen, S, Sharma, R, Prasad, S, Lyon, AR, Carpenter, JP, Senior, R, Breithardt, O-A, Razavi, H, Arya, A, Nabutovsky, Y, Ryu, K, Gaspar, T, Kosiuk, J, Eitel, C, Hindricks, G, Piorkowski, C, Pires, S, Nunes, A, Cortez-Dias, N, Belo, A, Zimbarra Cabrita, I, Sousa, C, Pinto, F, Baron, T, Johansson, K, Flachskampf, FA, Christersson, C, Pires, S, Cortez-Dias, N, Nunes, A, Belo, A, Zimbarra Cabrita, I, Sousa, C, Pinto, F, Santoro, A, Federico Alvino, FA, Giovanni Antonelli, GA, Raffaella De Vito, RDV, Roberta Molle, RM, Sergio Mondillo, SM, Gustafsson, M, Alehagen, U, Johansson, P, Tsukishiro, Y, Onishi, T, Chimura, M, Yamada, S, Taniguchi, Y, Yasaka, Y, Kawai, H, Souza, J R M, Zacharias, L G T, Pithon, K R, Ozahata, T M, Cliquet, A JR, Blotta, M H, Nadruz, W JR, Fabiani, I, Conte, L, Cuono, C, Liga, R, Giannini, C, Barletta, V, Nardi, C, Delle Donne, MG, Palagi, C, Di Bello, V, Glaveckaite, S, Valeviciene, N, Palionis, D, Laucevicius, A, Hristova, K, Bogdanova, V, Ferferieva, V, Shiue, I, Castellon, X, Boles, U, Rakhit, R, Shiu, M F, Gilbert, T, Papachristidis, A, Henein, M Y, Westholm, C, Johnson, J, Jernberg, T, Winter, R, Ghosh Dastidar, A, Augustine, D, Cengarle, M, Mcalindon, E, Bucciarelli-Ducci, C, Nightingale, A, Onishi, T, Watanabe, T, Fujita, M, Mizukami, Y, Sakata, Y, Nakatani, S, Nanto, S, Uematsu, M, Saraste, A, Luotolahti, M, Varis, A, Vasankari, T, Tunturi, S, Taittonen, M, Rautakorpi, P, Airaksinen, J, Ukkonen, H, Knuuti, J, Boshchenko, A, Vrublevsky, A, Karpov, R, Yoshikawa, H, Suzuki, M, Hashimoto, G, Kusunose, Y, Otsuka, T, Nakamura, M, Sugi, K, Rosner, SJ, Orban, M, Lesevic, H, Karl, M, Hadamitzky, M, Sonne, C, Panaro, A, Martinez, F, Huguet, M, Moral, S, Palet, J, Oller, G, Cuso, I, Jornet, A, Rodriguez Palomares, J, Evangelista, A, Stoebe, S, Tarr, A, Pfeiffer, D, Hagendorff, A, Gilmanov, DSH, Baroni, MB, Cerone, EC, Galli, EG, Berti, SB, Glauber, MG, Soesanto, A, Yuniadi, Y, Mansyur, M, Kusmana, D, Venkateshvaran, A, Dash, P K, Sola, S, Govind, S C, Shahgaldi, K, Winter, R, Brodin, L A, Manouras, A, Dokainish, H, Sadreddini, M, Nieuwlaat, R, Lonn, E, Healey, J, Nguyen, V, Cimadevilla, C, Dreyfus, J, Codogno, I, Vahanian, A, Messika-Zeitoun, D, Lim, Y-J, Kawamura, A, Kawano, S, Polte, CL, Gao, S, Lagerstrand, KM, Cederbom, U, Bech-Hanssen, O, Baum, J, Beeres, F, Van Hall, S, Boering, YC, Zeus, T, Kehmeier, ES, Kelm, M, Balzer, JC, Della Mattia, A, Pinamonti, B, Abate, E, Nicolosi, GL, Proclemer, A, Bassetti, M, Luzzati, R, Sinagra, G, Hlubocka, Z, Jiratova, K, Dostalova, G, Hlubocky, J, Dohnalova, A, Linhart, A, Palecek, T, Sonne, C, Lesevic, H, Karl, M, Rosner, S, Hadamitzky, M, Ott, I, Malev, E, Reeva, S, Zemtsovsky, E, Igual Munoz, B, Alonso Fernandez Pau, PAF, Miro Palau Vicente, VMP, Maceira Gonzalez Alicia, AMG, Estornell Erill, JEE, Andres La Huerta, AALH, Donate Bertolin, LDB, Valera Martinez, FVM, Salvador Sanz Antonio, ASS, Montero Argudo Anastasio, AMA, Nemes, A, Kalapos, A, Domsik, P, Chadaide, S, Sepp, R, Forster, T, Onaindia, JJ, Arana, X, Cacicedo, A, Velasco, S, Rodriguez, I, Capelastegui, A, Sadaba, M, Gonzalez, J, Salcedo, A, Laraudogoitia, E, Archontakis, S, Gatzoulis, K, Vlasseros, I, Arsenos, P, Tsiachris, D, Vouliotis, A, Sideris, S, Karistinos, G, Kalikazaros, I, Stefanadis, C, Ancona, R, Comenale Pinto, S, Caso, P, Coppola, MG, Arenga, F, Cavallaro, C, Vecchione, F, Donofrio, A, Calabro, R, Correia, C E, Moreira, D, Cabral, C, Santos, JO, Cardoso, JS, Igual Munoz, B, Maceira Gonzalez, AMG, Estornell Erill Jordi, JEE, Jimenez Carreno, RJC, Arnau Vives, MAV, Monmeneu Menadas, JVMM, Domingo-Valero, DDV, Sanchez Fernandez, ESF, Montero Argudo Anastasio, AMA, Zorio Grima, EZG, Cincin, A, Tigen, K, Karaahmet, T, Dundar, C, Sunbul, M, Guler, A, Bulut, M, Basaran, Y, Mordi, I, Carrick, D, Berry, C, Tzemos, N, Cruz, I, Ferreira, A, Rocha Lopes, L, Joao, I, Almeida, AR, Fazendas, P, Cotrim, C, Pereira, H, Ochoa, J P, Fernandez, A, Filipuzzi, JM, Casabe, JH, Salmo, JF, Vaisbuj, F, Ganum, G, Di Nunzio, HJ, Veron, LF, Guevara, E, Salemi, VMC, Nerbass, FB, Portilho, N, Ferreira Filho, JCA, Pedrosa, RP, Arteaga-Fernandez, E, Mady, C, Drager, LF, Lorenzi-Filho, G, Marques, JS, Almeida, A M G, Menezes, M, Silva, GL, Placido, R, Amaro, C, Brito, D, Diogo, AN, Lourenco, M R, Azevedo, O, Moutinho, J, Nogueira, I, Machado, I, Portugues, J, Quelhas, I, Lourenco, A, Calore, C, Muraru, D, Melacini, P, Badano, LP, Mihaila, S, Puma, L, Peluso, D, Casablanca, S, Ortile, A, Iliceto, S, Kang, M-K, Yu, SH, Park, JJ, Kim, SH, Park, TY, Mun, H-S, C, S, Cho, S-R, Han, SW, Lee, N, Khalifa, E A, Hamodraka, E, Kallistratos, M, Zacharopoulou, I, Kouremenos, N, Mavropoulos, D, Tsoukas, A, Kontogiannis, N, Papanikolaou, N, Tsoukanas, K, Manolis, A, Villagraz Tecedor, L, Jimenez Lopez Guarch, C, Alonso Chaterina, S, Blazquez Arrollo, L, Lopez Melgar, B, Veitia Sarmiento, AL, Mayordomo Gomez, S, Escribano Subias, MP, Lichodziejewska, B, Kurnicka, K, Goliszek, S, Dzikowska Diduch, O, Kostrubiec, M, Krupa, M, Grudzka, K, Ciurzynski, M, Palczewski, P, Pruszczyk, P, Sakata, K, Ishiguro, M, Kimura, G, Uesugo, Y, Takemoto, K, Minamishima, T, Futuya, M, Matsue, S, Satoh, T, Yoshino, H, Signorello, MC, Gianturco, L, Colombo, C, Stella, D, Atzeni, F, Boccassini, L, Sarzi-Puttini, PC, Turiel, M, Kinova, E, Deliiska, B, Krivoshiev, S, Goudev, A, De Stefano, F, Santoro, C, Buonauro, A, Schiano-Lomoriello, V, Muscariello, R, De Palma, D, Galderisi, M, Ranganadha Babu, B, Chidambaram, SUNDAR, Sangareddi, V, Dhandapani, VE, Ravi, MS, Meenakshi, K, Muthukumar, D, Swaminathan, N, Ravishankar, G, Bruno, R M, Giardini, G, Catizzo, B, Brustia, R, Malacrida, S, Armenia, S, Cauchy, E, Pratali, L, Resamont2, Cesana, F, Alloni, M, Vallerio, P, De Chiara, B, Musca, F, Belli, O, Ricotta, R, Siena, S, Moreo, A, Giannattasio, C, Magnino, C, Omede, P, Avenatti, E, Presutti, D, Sabia, L, Moretti, C, Bucca, C, Gaita, F, Veglio, F, Milan, A, Eichhorn, JG, Springer, W, Helling, A, Alarajab, A, Loukanov, T, Ikeda, M, Kijima, Y, Akagi, T, Toh, N, Oe, H, Nakagawa, K, Tanabe, Y, Watanabe, N, Ito, H, Hascoet, S, Hadeed, K, Marchal, P, Bennadji, A, Peyre, M, Dulac, Y, Heitz, F, Alacoque, X, Chausseray, G, Acar, P, Kong, WILL, Ling, LH, Yip, JAMES, Poh, KK, Vassiliou, V, Rekhraj, S, Hoole, SP, Watkinson, O, Kydd, A, Boyd, J, Mcnab, D, Densem, C, Shapiro, LM, Rana, BS, Potpara, TS, Djikic, D, Polovina, M, Marcetic, Z, Peric, V, Lip, GYH, Gaudron, P, Niemann, M, Herrmann, S, Hu, K, Strotmann, J, Beer, M, Bijnens, B, Liu, D, Ertl, G, Weidemann, F, Peric, V, Jovanovic, A, Djikic, D, Otasevic, P, Kochanowski, J, Piatkowski, R, Scislo, P, Grabowski, M, Marchel, M, Opolski, G, Bandera, F, Guazzi, M, Arena, R, Corra, U, Ghio, S, Forfia, P, Rossi, A, Dini, F, Cahalin, LP, Temporelli, L, Rallidis, L, Tsangaris, I, Makavos, G, Anthi, A, Pappas, A, Orfanos, S, Lekakis, J, Anastasiou-Nana, M, Kuznetsov, V A, Krinochkin, D V, Yaroslavskaya, E I, Zaharova, E H, Pushkarev, G S, Mizia-Stec, K, Wita, K, Mizia, M, Loboz-Grudzien, K, Szwed, H, Kowalik, I, Kukulski, T, Gosciniak, P, Kasprzak, J, Plonska-Gosciniak, E, Cimino, S, Pedrizzetti, G, Tonti, G, Cicogna, F, Petronilli, V, De Luca, L, Iacoboni, C, Agati, L, Hoffmann, R, Barletta, G, Von Bardeleben, S, Kasprzak, J, Greis, C, Vanoverschelde, J, Becher, H, Galrinho, A, Moura Branco, L, Fiarresga, A, Cacela, D, Ramos, R, Cruz Ferreira, R, Van Den Oord, SCH, Akkus, Z, Bosch, JG, Renaud, G, Sijbrands, EJG, Verhagen, HJM, Van Der Lugt, A, Van Der Steen, AFW, Schinkel, AFL, Mordi, I, Tzemos, N, Stanton, T, Delgado, D, Yu, E, Drakopoulou, M, Gonzalez-Gonzalez, AM, Karonis, T, Roussin, I, Babu-Narayan, S, Swan, L, Senior, R, Li, W, Parisi, V, Pagano, G, Pellegrino, T, Femminella, GD, De Lucia, C, Formisano, R, Cuocolo, A, Perrone Filardi, P, Leosco, D, Rengo, G, Unlu, S, Farsalinos, K, Amelot, K, Daraban, A, Ciarka, A, Delcroix, M, Voigt, JU, Miskovic, A, Poerner, TD, Goebel, B, Stiller, CH, Moritz, A, Sakata, K, Uesugo, Y, Kimura, G, Ishiguro, M, Takemoto, K, Minamishima, T, Futuya, M, Satoh, T, Yoshino, H, Miyoshi, T, Tanaka, H, Kaneko, A, Matsumoto, K, Imanishi, J, Motoji, Y, Mochizuki, Y, Minami, H, Kawai, H, Hirata, K, Wutthimanop, A, See, O, Vathesathokit, P, Yamwong, S, Sritara, P, Rosner, A, Kildal, AB, Stenberg, TA, Myrmel, T, How, OJ, Capriolo, M, Frea, S, Giustetto, C, Scrocco, C, Benedetto, S, Grosso Marra, W, Morello, M, Gaita, F, Garcia-Gonzalez, P, Cozar-Santiago, P, Chacon-Hernandez, N, Ferrando-Beltran, M, Fabregat-Andres, O, De La Espriella-Juan, R, Fontane-Martinez, C, Jurado-Sanchez, R, Morell-Cabedo, S, Ridocci-Soriano, F, Mihaila, S, Piasentini, E, Muraru, D, Peluso, D, Casablanca, S, Puma, L, Naso, P, Iliceto, S, Vinereanu, D, Badano, LP, Tarzia, P, Villano, A, Figliozzi, S, Russo, G, Parrinello, R, Lamendola, P, Sestito, A, Lanza, GA, Crea, F, Sulemane, S, Panoulas, VF, Bratsas, A, Frankel, AH, Nihoyannopoulos, P, Dores, H, Andrade, MJ, Almeida, MS, Goncalves, PA, Branco, P, Gaspar, A, Gomes, A, Horta, E, Carvalho, MS, Mendes, M, Yue, WS, Li, XY, Chen, Y, Luo, Y, Gu, P, Yiu, KH, Siu, CW, Tse, HF, Cho, EJ, Lee, SH, Hwang, BH, Kim, DB, Jang, SW, Jeon, HK, Youn, HJ, and Kim, JH
- Abstract
Background: Progress in the technique of TAVR requires good knowledge of the aortic root. With this aim new specialized software appears, with the ability of automated quantitative modeling of the AV and root from 3D TEE.The purpose of this study was to validate this model with the measurements made manually. Methods: Eight patients undergoing TAVR in our center where included. The diameters of the aortic annulus, sinotubular union (STU) and sinus of valsalva (SV) were measured by 2D TEE; diameters and areas of aortic annulus, STU and SV as well as anatomic aortic valve area were measured by 3D TEE. Afterwards, the images were analyzed using the new software (Figure 1). Results. We showed good correlation with aortic annulus diameter measured by 2D TEE (r:,832 p:,01) and excellent correlation with one of the aortic annulus diameter measured by 3D TEE (r:,941 p:,00). The same happened with the area (r:,720 p:,04). Regarding the measurements at SV level, the correlations between the diameters by 2D TEE and 3D TEE with the measurements obtained with the new model were the following (r:,771;p:,025) and (r:,797;p:,018). The correlation of the area was also good (r:,812 p:,014).An excellent correlation was found between the measurements at UST level. UST diameter by 2D TEE (r:,818;P:,013), by ETE3D (r:,800;p:,017) and area (r:,844;p:,008).Finally, the anatomic aortic valve area measured by the new model showed significant correlation with the 3D TTE (r:,830 p:,011). Conclusions. There is a proper correlation between manual and automated measurements analyzed by the new model. The feasibility of determine the TAVR results with geometric models based on image, prior to procedure, is one of the possibilities of this new software. Prospective studies are necessary to define its applicability.
Figure 1 - Published
- 2013
- Full Text
- View/download PDF
36. The use of dedicated long-axis views focused on the left atrium improves the accuracy of left atrial volumes and emptying fraction measured by cardiovascular magnetic resonance
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Lara Tondi, Luigi P. Badano, Stefano Figliozzi, Silvia Pica, Camilla Torlasco, Antonia Camporeale, Diana R. Florescu, Giandomenico Disabato, Gianfranco Parati, Massimo Lombardi, Denisa Muraru, Tondi, L, Badano, L, Figliozzi, S, Pica, S, Torlasco, C, Camporeale, A, Florescu, D, Disabato, G, Parati, G, Lombardi, M, and Muraru, D
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Left atrial emptying fraction ,Radiological and Ultrasound Technology ,Cardiac magnetic resonance ,Left atrial strain ,Radiology, Nuclear Medicine and imaging ,Left atrial volume ,Cardiology and Cardiovascular Medicine ,Accuracy - Abstract
Background The use of apical views focused on the left atrium (LA) has improved the accuracy of LA volume evaluation by two-dimensional (2D) echocardiography. However, routine cardiovascular magnetic resonance (CMR) evaluation of LA volumes still uses standard 2- and 4-chamber cine images focused on the left ventricle (LV). To investigate the potential of LA-focused CMR cine images, we compared LA maximuml (LAVmax) and minimum (LAVmin) volumes, and emptying fraction (LAEF), calculated on both standard and LA-focused long-axis cine images, with LA volumes and LAEF obtained by short-axis cine stacks covering the LA. LA strain was also calculated and compared between standard and LA-focused images. Methods LA volumes and LAEF were obtained from 108 consecutive patients by applying the biplane area-length algorithm to both standard and LA-focused 2- and 4-chamber cine images. Manual segmentation of a short-axis cine stack covering the LA was used as the reference method. In addition, LA strain reservoir (εs), conduit (εe) and booster pump (εa) were calculated using CMR feature-tracking. Results Compared to the reference method, the standard approach significantly underestimated LA volumes (LAVmax: bias − 13 ml; LOA = + 11, − 37 ml; LAVmax i: bias − 7 ml/m2; LOA = + 7, − 21 ml/m2; LAVmin; bias − 10 ml, LOA: + 9, − 28 ml; LAVmin i: bias − 5 ml/m2, LOA: + 5, − 16 ml/m2), and overestimated LA-EF (bias 5%, LOA: + 23, − 14%). Conversely, LA volumes (LAVmax: bias 0 ml; LOA: + 10, − 10 ml; LAVmax i: bias 0 ml/m2; LOA: + 5, − 6 ml/m2; LAVmin: bias − 2 ml; LOA: + 7, − 10 ml; LAVmin i: bias − 1 ml/m2; LOA: + 3, − 5 ml/m2) and LAEF (bias 2%, LOA: + 11, − 7%) by LA-focused cine images were similar to those measured using the reference method. LA volumes by LA-focused images were obtained faster than using the reference method (1.2 vs 4.5 min, p Conclusion LA volumes and LAEF measured using dedicated LA-focused long-axis cine images are more accurate than using standard LV-focused cine images. Moreover, LA strain is significantly lower in LA-focused vs. standard images.
- Published
- 2023
37. ECG-based score estimates the probability to detect Fabry Disease cardiac involvement
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Kelvin Chow, Massimo Lombardi, Paola Lusardi, Antonia Camporeale, Andrea Bernardini, Sara Boveri, Mehdi Namdar, Federico Pieruzzi, Alessandro P. Burlina, Marco Spada, Lara Tondi, Silvia Pica, Renzo Mignani, Maurizio Pieroni, Stefano Figliozzi, Francesca Graziani, Figliozzi, S, Camporeale, A, Boveri, S, Pieruzzi, F, Pieroni, M, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Graziani, F, Pica, S, Tondi, L, Bernardini, A, Chow, K, Namdar, M, and Lombardi, M
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medicine.medical_specialty ,Intraclass correlation ,Magnetic Resonance Imaging, Cine ,Electrocardiography ,QRS complex ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Probability ,Fabry disease ,Ejection fraction ,medicine.diagnostic_test ,Left bundle branch block ,business.industry ,Myocardium ,T1 mapping ,Nomogram ,medicine.disease ,Magnetic Resonance Imaging ,Cross-Sectional Studies ,Early Diagnosis ,Cine ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Cohort ,cardiovascular system ,Cardiology ,Cardiovascular magnetic resonance ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives To elaborate an ECG-based nomogram estimating the probability to detect cardiac involvement by cardiac magnetic resonance (CMR) in Fabry Disease (FD). Methods 119 FD patients and 26 healthy controls underwent ECG and CMR. Test (n = 88, 60%) and validation cohorts (n = 57, 40%) were randomly derived. Cardiac involvement was defined as the presence of low myocardial T1 value, a CMR-surrogate of myocardial glycosphingolipid storage. ECG changes associated with low T1 value were identified in the test cohort, included in the nomogram and then tested in the validation cohort. Results Sokolow-Lyon index (AUC = 0.769), ratio between P-wave and PR-segment durations (Pwave/PRsegment) (AUC = 0.778), QRS duration (AUC = 0.703), QT (AUC = 0.769) duration were independently associated with the presence of low T1 on CMR at multivariate analysis. An ECG-based nomogram including these four parameters was accurate in identifying patients with CMR evidence of glycosphingolipid storage (c-index of the derived-nomogram = 0.90 in the test group; 0.81 in the validation group). Conclusion We propose a practical ECG-based nomogram accurately estimating the probability to detect low T1 values by CMR in FD patients. The application of this tool in clinical practice could improve early detection of FD cardiac involvement.
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- 2021
38. Myocardial Fibrosis at Cardiac MRI Helps Predict Adverse Clinical Outcome in Patients with Mitral Valve Prolapse
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Stefano Figliozzi, Georgios Georgiopoulos, Pedro M. Lopes, Klemens B. Bauer, Sara Moura-Ferreira, Lara Tondi, Saima Mushtaq, Stefano Censi, Anna Giulia Pavon, Ilaria Bassi, Maria Luz Servato, Arco J. Teske, Federico Biondi, Domenico Filomena, Silvia Pica, Camilla Torlasco, Denisa Muraru, Pierre Monney, Giuseppina Quattrocchi, Viviana Maestrini, Luciano Agati, Lorenzo Monti, Patrizia Pedrotti, Bert Vandenberk, Angelo Squeri, Massimo Lombardi, António M. Ferreira, Juerg Schwitter, Giovanni Donato Aquaro, Amedeo Chiribiri, José F. Rodríguez Palomares, Ali Yilmaz, Daniele Andreini, Anca Florian, Tim Leiner, João Abecasis, Luigi Paolo Badano, Jan Bogaert, Pier-Giorgio Masci, Figliozzi, S, Georgiopoulos, G, Lopes, P, Bauer, K, Moura-Ferreira, S, Tondi, L, Mushtaq, S, Censi, S, Pavon, A, Bassi, I, Servato, M, Teske, A, Biondi, F, Filomena, D, Pica, S, Torlasco, C, Muraru, D, Monney, P, Quattrocchi, G, Maestrini, V, Agati, L, Monti, L, Pedrotti, P, Vandenberk, B, Squeri, A, Lombardi, M, Ferreira, A, Schwitter, J, Aquaro, G, Chiribiri, A, Rodríguez Palomares, J, Yilmaz, A, Andreini, D, Florian, A, Leiner, T, Abecasis, J, Badano, L, Bogaert, J, and Masci, P
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Radiology, Nuclear Medicine and imaging ,myocardial fibrosis ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,mitral valve prolapse ,cardiac magnetic resonance - Abstract
Background: Patients with mitral valve prolapse (MVP) may develop adverse outcomes even in the absence of mitral regurgitation or left ventricular (LV) dysfunction. Purpose: To investigate the prognostic value of mitral annulus disjunction (MAD) and myocardial fibrosis at late gadolinium enhancement (LGE) cardiac MRI in patients with MVP without moderate-to-severe mitral regurgitation or LV dysfunction. Materials and Methods: In this longitudinal retrospective study, 118 144 cardiac MRI studies were evaluated between October 2007 and June 2020 at 15 European tertiary medical centers. Follow-up was from the date of cardiac MRI examination to June 2020; the minimum and maximum follow-up intervals were 6 months and 156 months, respectively. Patients were excluded if at least one of the following conditions was present: cardiomyopathy, LV ejection fraction less than 40%, ischemic heart disease, congenital heart disease, inflammatory heart disease, moderate or worse mitral regurgitation, participation in competitive sport, or electrocardiogram suggestive of channelopathies. In the remainder, cardiac MRI studies were reanalyzed, and patients were included if they were aged 18 years or older, MVP was diagnosed at cardiac MRI, and clinical information and electrocardiogram monitoring were available within 3 months from cardiac MRI examination. The end point was a composite of adverse outcomes: sustained ventricular tachycardia (VT), sudden cardiac death (SCD), or unexplained syncope. Multivariable Cox regression analysis was performed. Results: A total of 474 patients (mean age, 47 years ± 16 [SD]; 244 women) were included. Over a median follow-up of 3.3 years, 18 patients (4%) reached the study end point. LGE presence (hazard ratio, 4.2 [95% CI: 1.5, 11.9]; P = .006) and extent (hazard ratio, 1.2 per 1% increase [95% CI: 1.1, 1.4]; P = .006), but not MAD presence (P = .89), were associated with clinical outcome. LGE presence had incremental prognostic value over MVP severity and sustained VT and aborted SCD at baseline (area under the receiver operating characteristic curve, 0.70 vs 0.62; P = .03). Conclusion: In contrast to mitral annulus disjunction, myocardial fibrosis determined according to late gadolinium enhancement at cardiac MRI was associated with adverse outcome in patients with mitral valve prolapse without moderate-to-severe mitral regurgitation or left ventricular dysfunction.
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- 2022
39. Atrial functional tricuspid regurgitation: a novel and underappreciated clinical entity
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Stefano Vicini, Luigi P. Badano, Octavian Istrătoaie, A C Guta, Diana-Ruxandra Florescu, Michele Tomaselli, Georgică Costinel Târtea, Gianfranco Parati, Stefano Figliozzi, Denisa Muraru, Florescu, D, Figliozzi, S, Guta, A, Vicini, S, Tomaselli, M, Târtea, G, Istrătoaie, O, Parati, G, Badano, L, and Muraru, D
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medicine.medical_specialty ,business.industry ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,tricuspid valve ,RC31-1245 ,transthoracic echocardiography ,Functional tricuspid regurgitation ,Internal medicine ,atrial functional tricuspid regurgitation ,three-dimensional echocardiography ,cardiovascular system ,medicine ,Cardiology ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business - Abstract
Functional or secondary tricuspid regurgitation (FTR) is a progressive disease with a significant negative impact on patient morbidity and mortality. Recently, atrial fibrillation (AF) has been recognized as a cause of FTR (with/without coexisting functional mitral regurgitation) by promoting right atrial (RA) remodeling and secondary tricuspid valve (TV) annulus dilation, even in the absence of right ventricular (RV) dilation or dysfunction. This distinct form of FTR has been called “atriogenic” or “atrial”. Recent evidence suggests that the RA is an important player in FTR pathophysiology not only for patients with AF, but also for those in sinus rhythm. Preliminary reports on atrial FTR show that cardioversion with documented maintenance of sinus rhythm promotes TV annulus and RA reverse remodeling and may significantly reduce FTR severity at follow-up. Large-scale studies on the prognostic benefits of rhythm vs rate-control strategy in atrial FTR patients are needed to substantiate specific guidelines indications for this subset of patients.
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- 2021
40. Effective Study: Development and Application of a Question‐Driven, Time‐Effective Cardiac Magnetic Resonance Scanning Protocol
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Camilla Torlasco, Silvia Castelletti, Davide Soranna, Valentina Volpato, Stefano Figliozzi, Katia Menacho, Franco Cernigliaro, Antonella Zambon, Peter Kellman, James C. Moon, Luigi P. Badano, Gianfranco Parati, Torlasco, C, Castelletti, S, Soranna, D, Volpato, V, Figliozzi, S, Menacho, K, Cernigliaro, F, Zambon, A, Kellman, P, Moon, J, Badano, L, and Parati, G
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Magnetic Resonance Spectroscopy ,Myocardial Ischemia ,Contrast Media ,Magnetic Resonance Imaging, Cine ,rapid scanning ,Gadolinium ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,ischemic heart disease ,cardiovascular magnetic resonance ,Predictive Value of Tests ,RC666-701 ,cardiovascular system ,Humans ,time‐effectiveness ,Diseases of the circulatory (Cardiovascular) system ,Time-effectivene ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,Cardiomyopathies ,cardiomyopathy ,circulatory and respiratory physiology - Abstract
Background Long scanning times impede cardiac magnetic resonance (CMR) clinical uptake. A “one‐size‐fits‐all” shortened, focused protocol (eg, only function and late‐gadolinium enhancement) reduces scanning time and costs, but provides less information. We developed 2 question‐driven CMR and stress‐CMR protocols, including tailored advanced tissue characterization, and tested their effectiveness in reducing scanning time while retaining the diagnostic performances of standard protocols. Methods and Results Eighty three consecutive patients with cardiomyopathy or ischemic heart disease underwent the tailored CMR. Each scan consisted of standard cines, late‐gadolinium enhancement imaging, native T1‐mapping, and extracellular volume. Fat/edema modules, right ventricle cine, and in‐line quantitative perfusion mapping were performed as clinically required. Workflow was optimized to avoid gaps. Time target was 30% (CMR: from 42±8 to 28±6 minutes; stress‐CMR: from 50±10 to 34±6 minutes, both P 45% of cases. Quality grading was similar between the 2 protocols. Tailored protocols did not require additional staff. Conclusions Tailored CMR and stress‐CMR protocols including advanced tissue characterization are accurate and time‐effective for cardiomyopathies and ischemic heart disease.
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- 2022
41. Recent advances in multimodality imaging of the tricuspid valve
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Luigi P. Badano, Giuseppe Muscogiuri, Diana-Ruxandra Florescu, Gianfranco Parati, Valentina Volpato, Stefano Figliozzi, Franco Cernigliaro, Michele Tomaselli, Giorgio Oliverio, Denisa Muraru, Camilla Torlasco, Sergio Caravita, Caravita, S, Figliozzi, S, Florescu, D, Volpato, V, Oliverio, G, Tomaselli, M, Torlasco, C, Muscogiuri, G, Cernigliaro, F, Parati, G, Badano, L, and Muraru, D
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medicine.medical_specialty ,Population ,Biomedical Engineering ,Echocardiography, Three-Dimensional ,Computed tomography ,Settore MED/11 - Malattie dell'Apparato Cardiovascolare ,Regurgitation (circulation) ,tricuspid valve ,Multimodal Imaging ,cardiac magnetic resonance ,Multimodality ,multimodality imaging ,medicine ,Humans ,education ,Intensive care medicine ,tricuspid regurgitation ,Cardiac imaging ,Heart Valve Prosthesis Implantation ,education.field_of_study ,Tricuspid valve ,3D echocardiography ,medicine.diagnostic_test ,business.industry ,Hemodynamics ,computed tomography ,General Medicine ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,echocardiography ,tricuspid valve interventions ,Tricuspid Valve ,Tricuspid Valve Insufficiency ,medicine.anatomical_structure ,Echocardiography ,Right heart ,Three-Dimensional ,Surgery ,business ,Cardiac magnetic resonance ,tricuspid valve intervention - Abstract
Introduction: The tricuspid valve (TV) and the right heart chambers are complex three-dimensional structures that are difficult to assess using tomographic imaging techniques. The progressive aging of the general population and the advancements in treating left-sided heart diseases by transcatheter procedures have contributed to the tricuspid regurgitation (TR) becoming a major public health problem associated with progression to refractory heart failure and poor outcome. Recent advances in multimodality cardiac imaging allow a better understanding of the pathophysiology of TR that may translate in better management of patients. Areas covered: Three-dimensional echocardiography, cardiac magnetic resonance, and computed tomography provide complementary information to i. assess the TV complex; ii. identify the etiology and the mechanisms of TR; iii. evaluate its severity and hemodynamic consequences; iv. explore the remodeling of the right heart chambers; and v. properly plan, guide, and monitor the transcatheter interventions aimed to reduce the severity of TR. Expert opinion: We need thorough understanding of both the TV and the right heart chamber geometry and function to understand the pathophysiology of TR. The integrated use of multimodality cardiac imaging is pivotal to assess patients with TR and to identify tailored and timely treatment of TR in properly selected patients.
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- 2021
42. Prognostic validation of partition values for quantitative parameters to grade functional tricuspid regurgitation severity by conventional echocardiography
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Dario Gregori, Roberto C. Ochoa-Jimenez, Daniele Bottigliengo, Stefano Figliozzi, Denisa Muraru, A C Guta, Luigi P. Badano, Marco Previtero, Gianfranco Parati, Muraru, D, Previtero, M, Ochoa-Jimenez, R, Guta, A, Figliozzi, S, Gregori, D, Bottigliengo, D, Parati, G, and Badano, L
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medicine.medical_specialty ,Echocardiography, Three-Dimensional ,Tricuspid regurgitation ,030204 cardiovascular system & hematology ,Doppler echocardiography ,Effective Regurgitant Orifice Area ,Severity of Illness Index ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Tricuspid valve ,Effective regurgitant orifice area ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Outcome ,Vena contracta ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Stroke Volume ,General Medicine ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Vena contracta width ,medicine.disease ,Prognosis ,Tricuspid Valve Insufficiency ,Echocardiography, Doppler, Color ,Regurgitant fraction ,medicine.anatomical_structure ,Blood pressure ,Echocardiography ,Heart failure ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Regurgitant volume - Abstract
Aims Quantitative echocardiography parameters are seldom used to grade tricuspid regurgitation (TR) severity due to relative paucity of validation studies and lack of prognostic data. To assess the relationship between TR severity and the composite endpoint of death and hospitalization for congestive heart failure (CHF); and to identify the threshold values of vena contracta width (VCavg), effective regurgitant orifice area (EROA), regurgitant volume (RegVol), and regurgitant fraction (RegFr) to define low, intermediate, and high-risk TR based on patients’ outcome data. Methods and results A cohort of 296 patients with at least mild TR underwent 2D, 3D, and Doppler echocardiography. We built statistical models (adjusted for age, NYHA class, left ventricular ejection fraction, and pulmonary artery systolic pressure) for VCavg, EROA, RegVol, and RegFr to study their relationships with the hazard of outcome. The tertiles of the derived hazard values defined the threshold values of the quantitative parameters for TR severity grading. During 47-month follow-up, 32 deaths and 72 CHF occurred. Event-free rate was 14%, 48%, and 93% in patients with severe, moderate, and mild TR, respectively. Severe TR was graded as VCavg > 6 mm, EROA > 0.30 cm2, RegVol > 30 mL, and RegF > 45%. Conclusion This outcome study demonstrates the prognostic value of quantitative parameters of TR severity and provides prognostically meaningful threshold values to grade TR severity in low, intermediate, and high risk.
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- 2021
43. Multimodality cardiac imaging and new display options to broaden our understanding of the tricuspid valve
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Stefano Figliozzi, Diana R Florescu, Valentina Volpato, Denisa Muraru, Luigi P. Badano, Gianfranco Parati, Volpato, V, Badano, L, Figliozzi, S, Florescu, D, Parati, G, and Muraru, D
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medicine.medical_specialty ,Modalities ,Tricuspid valve ,Cardiac computed tomography ,business.industry ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,tricuspid valve ,Multimodal Imaging ,Tricuspid Valve Insufficiency ,Multimodality ,multimodality imaging ,Cardiac Imaging Techniques ,medicine.anatomical_structure ,Echocardiography ,Close relationship ,Right heart ,medicine ,Humans ,Medical physics ,Cardiology and Cardiovascular Medicine ,Cardiac magnetic resonance ,business ,tricuspid regurgitation ,Cardiac imaging - Abstract
PURPOSE OF REVIEW The prognostic impact of tricuspid regurgitation (TR) and the subsequent development of percutaneous procedures targeting the tricuspid valve (TV), has brought to the forefront the role of imaging for the assessment of the forgotten valve. As illustrated in several studies and summarized in this review, currently a multimodality imaging approach is required to understand the pathophysiology of TR, due to the complex TV anatomy and the close relationship between the severity of TR and the extent of the remodeling of the right heart chambers. RECENT FINDINGS Recently, the advance in the tranhscatheter treatment of the TV has led to a growing interest in the development of dedicated software packages and new display modalities to increase our understanding of the TV. As a consequence, a transversal knowledge of the different imaging modalities is required for contemporary cardiac-imaging physicians. SUMMARY This review highlights the main features, and the pros and cons of echocardiography, cardiac computed tomography, cardiac magnetic resonance and emerging technologies, as 3D printing and virtual reality, in the assessment of patients with TR.
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- 2021
44. Atrial Dysfunction Assessed by Cardiac Magnetic Resonance as an Early Marker of Fabry Cardiomyopathy
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Andrea Bernardini, Francesca Carubbi, Maurizio Pieroni, Yuri Battaglia, Kelvin Chow, Alessandro P. Burlina, Marco Spada, Paola Lusardi, Silvia Pica, Renzo Mignani, Stefano Figliozzi, Massimo Lombardi, Francesca Graziani, Lara Tondi, Sara Boveri, Iacopo Olivotto, Antonia Camporeale, Federico Pieruzzi, Bernardini, A, Camporeale, A, Pieroni, M, Pieruzzi, F, Figliozzi, S, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Carubbi, F, Battaglia, Y, Graziani, F, Pica, S, Tondi, L, Chow, K, Boveri, S, Olivotto, I, and Lombardi, M
- Subjects
medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Cardiomyopathy ,030204 cardiovascular system & hematology ,Anderson-Fabry disease ,030218 nuclear medicine & medical imaging ,Muscle hypertrophy ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Left atrial ,Predictive Value of Tests ,Internal medicine ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Fabry disease, cardiomyopathy, atrial dysfunction, cardiac magnetic resonance, T1 mapping ,cardiovascular diseases ,Atrial myocytes ,Heart Atria ,LA strain ,business.industry ,Anderson-Fabry disease, T1 mapping, LA strain ,Glycosphingolipid ,T1 mapping ,medicine.disease ,Anderson-Fabry Disease ,chemistry ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,cardiovascular system ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Cardiac magnetic resonance ,Cardiomyopathies - Abstract
Anderson-Fabry disease (AFD) cardiomyopathy is characterized by glycosphingolipid (Gb3) storage in all cellular components, with consequent left ventricular hypertrophy (LVH). Gb3 accumulation also involves atrial myocytes ([1][1]), ultimately leading to left atrial (LA) enlargement and reduced
- Published
- 2020
45. Current clinical applications of three-dimensional echocardiography
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Luigi P, Badano, Patrizia, Aruta, Kim, Nguyen, Chiara, Palermo, Anna, Baritussio, Antonella, Cecchetto, Marco, Previtero, Stefano, Figliozzi, Davide, Genovese, Andrada C, Guta, Roberto C, Ochoa-Jimenez, Gianfranco, Parati, Denisa, Muraru, Badano, L, Aruta, P, Nguyen, K, Palermo, C, Baritussio, A, Cecchetto, A, Previtero, M, Figliozzi, S, Genovese, D, Guta, A, Ochoa-Jimenez, R, Parati, G, and Muraru, D
- Subjects
Heart Diseases ,Echocardiography ,Echocardiography, Three-Dimensional ,Mitral valve ,Humans ,Right ventricle ,Cardiac Surgical Procedures ,Left ventricle ,Three-dimensional echocardiography ,Heart Valves ,Tricuspid valve - Abstract
Three-dimensional echocardiography (3DE) represents one of the most innovative advances in cardiovascular imaging over the last 20 years. Recent technological developments have fueled the full implementation of 3DE in clinical practice and expanded its impact on patient diagnosis, management, and prognosis. One of the most important clinical applications of transthoracic 3DE has been the quantitation of cardiac chamber volumes and function. The main limitations affecting two-dimensional echocardiography calculations of chamber volumes (i.e. geometric assumptions about cardiac chamber shape and view foreshortening) are overcome by 3DE that allows an actual measurement of their volumes. Transesophageal 3DE has been applied mainly to assess the anatomy and function of heart valves, congenital defects and masses in the beating heart. As reparative cardiac surgery and transcatheter procedures have become more and more popular to treat structural heart disease, transesophageal 3DE has become not only one of the main imaging modalities for procedure planning but also for intra-procedural guidance and assessment of procedural results. New image rendering modalities such as 3D printing, holographic display, and fusion of 3DE images with other radiological or nuclear modalities will further expand the clinical applications and indications of 3DE.
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- 2019
46. Prognostic value of right ventricular involvement in hypertrophic cardiomyopathy: A systematic review and meta-analysis.
- Author
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Figliozzi S, Masci PG, Monti L, Stankowski K, Tondi L, Aivalioti E, Mavraganis G, Francone M, Condorelli G, Olivotto I, and Georgiopoulos G
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- Humans, Heart Ventricles diagnostic imaging, Heart Ventricles physiopathology, Prognosis, Cardiomyopathy, Hypertrophic complications, Cardiomyopathy, Hypertrophic diagnostic imaging, Cardiomyopathy, Hypertrophic mortality, Cardiomyopathy, Hypertrophic physiopathology, Ventricular Dysfunction, Right diagnostic imaging, Ventricular Dysfunction, Right epidemiology, Ventricular Dysfunction, Right etiology, Ventricular Dysfunction, Right physiopathology
- Abstract
Background: Right ventricular (RV) involvement has been reported in one out of three patients with hypertrophic cardiomyopathy (HCM), however its prognostic significance remains unknown. We aimed to assess the prognostic value of RV involvement in patients with HCM through a systematic review and meta-analysis., Methods: A literature search was performed on PubMed, ClinicalTrials.gov and Cochrane Library databases from inception through November 15, 2023. Original articles enrolling HCM patients >18 years old and evaluating the association of RV parameters routinely assessed in clinical practice through trans-thoracic echocardiography or cardiac magnetic resonance (i.e., RV hypertrophy, volumes, systolic function, and late gadolinium enhancement) and the risk of a pre-defined composite endpoint including i) all cause death; ii) cardiac death; iii) heart transplantation; iv) heart failure-related hospitalization; v) atrial fibrillation; vi) ventricular tachycardia; and vii) stroke were retrieved. We pooled the effect of RV imaging variables on the combined clinical endpoint in terms of hazard ratio (HR) with 95% confidence interval (CI)., Results: The meta-analysis included 12 articles and 4634 patients. The pooled analysis demonstrated that the presence of RV systolic dysfunction conveyed an increased risk of adverse outcomes (HR 2.46; 95% CI 1.80-3.35; P < 0.001), whereas other RV imaging parameters were not significantly associated with patients' prognosis, except for RV-fractional area change analyzed as a continuous variable (HR 0.96 per % increase; 95% CI 0.93-0.995; P = 0.025)., Conclusions: Our results pinpoint a prognostic role of RV dysfunction, independent of left ventricular involvement, in patients with HCM, and future longitudinal studies, including multi-parametric RV assessment, are encouraged to provide clinically-relevant data to refine risk stratification in patients with HCM., Competing Interests: Declaration of competing interest None., (Copyright © 2024. Published by Elsevier B.V.)
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- 2024
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47. Prognostic value of stress CMR and SPECT-MPI in patients undergoing intermediate-to-high-risk non-cardiac surgery.
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Fazzari F, Lisi C, Catapano F, Cannata F, Brilli F, Figliozzi S, Bragato RM, Stefanini GG, Monti L, and Francone M
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- Humans, Female, Male, Retrospective Studies, Aged, Middle Aged, Prognosis, Magnetic Resonance Imaging methods, Postoperative Complications diagnostic imaging, Risk Factors, Tomography, Emission-Computed, Single-Photon methods, Myocardial Perfusion Imaging methods, Exercise Test, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease surgery
- Abstract
Purpose: The objective of this study was to investigate the role of myocardial perfusion imaging (MPI) stress tests using stress cardiac magnetic resonance (sCMR) and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) in non-cardiac surgery (NCS) pre-operatory management., Materials and Methods: This monocentric retrospective study enrolled patients with coronary artery disease or a minimum of two cardiovascular risk factors undergoing intermediate-to-high-risk non-cardiac surgeries. The primary composite endpoint comprised cardiac death, cardiogenic shock, acute coronary syndromes (ACS), and cardiogenic pulmonary edema occurring within 30 days after surgery, while the secondary endpoint was ACS., Results: A total of 1590 patients were enrolled; among them, 669 underwent a MPI stress test strategy (sCMR: 287, SPECT-MPI: 382). The incidence of 30-day cardiac events was lower in the stress-tested group compared to the non-stress-tested group (1.2% vs. 3.4%; p 0.006). Adopting a stress test strategy showed a significant reduction in the risk of the composite endpoint (OR: 0.33, 95% CI: 0.15-0.76, p 0.009) and ACS (OR: 0.41, 95% CI: 0.17-0.98, p 0.046) at multivariable analysis, with similar cardiac events rate between stress CMR and SPECT (1.1% vs. 1.3%, p 0.756). Stress CMR showed a greater accuracy to predict coronary artery revascularizations (sCMR c-statistic: 0.95, ischemic cut-point: 5.5%; SPECT c-statistic: 0.85, ischemic cut-point: 7.5%)., Conclusion: Stress test strategy is related to a lower occurrence of cardiac events in high-risk patients scheduled for intermediate-to-high-risk non-cardiac surgeries. Both sCMR and SPECT-MPI comparably reduce the likelihood of cardiac complications, albeit sCMR offers greater accuracy in predicting coronary artery revascularization., (© 2024. The Author(s).)
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- 2024
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48. "Interstitial fibrosis is associated with left atrial remodeling and adverse clinical outcomes in selected low-risk patients with hypertrophic cardiomyopathy".
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Tondi L, Pica S, Crimi G, Disabato G, Figliozzi S, Camporeale A, Bernardini A, Tassetti L, Milani V, Piepoli MF, and Lombardi M
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- Humans, Male, Female, Middle Aged, Adult, Follow-Up Studies, Risk Factors, Aged, Atrial Function, Left physiology, Cardiomyopathy, Hypertrophic physiopathology, Cardiomyopathy, Hypertrophic diagnostic imaging, Atrial Remodeling physiology, Magnetic Resonance Imaging, Cine methods, Fibrosis
- Abstract
Background: Cardiovascular magnetic resonance (CMR) extracellular volume (ECV) allows non-invasive detection of myocardial interstitial fibrosis, which may be related to diastolic dysfunction and left atrial (LA) remodeling in hypertrophic cardiomyopathy (HCM). While the prognostic role of LGE is well-established, interstitial fibrosis and LA dysfunction are emerging novel markers in HCM. This study aimed to explore the interaction between interstitial fibrosis by ECV, LA morpho-functional parameters and adverse clinical outcomes in selected low-risk patients with HCM., Methods: 115 HCM patients and 61 matched controls underwent CMR to identify: i) interstitial fibrosis by ECV in hypertrophied left ventricular LGE-negative remote myocardium (r-ECV); ii) LA indexed maximum (LAVi max) and minimum (LAVi min) volumes, ejection fraction (LA-EF) and strain (reservoir εs, conduit εe and booster εa), by CMR feature-tracking. 2D-echocardiographic assessment of diastolic function was also performed within 6 months from CMR. A composite endpoint including worsening NYHA class, heart failure hospitalization, atrial fibrillation and all-cause death was evaluated at 2.3 years follow-up. HCM patients were divided into two groups, according to r-ECV values of controls., Results: Patients with r-ECV ≥29% (n = 45) showed larger LA volumes (LAVimax 63 vs. 54 ml/m
2 , p < 0.001; LAVimin 43 vs. 28 ml/m2 , p 〈0001), worse LA function (εs 16 vs. 28%, εe 8 vs. 15%, εa 8 vs. 14%, LA-EF 33 vs. 49%, all p < 0.001) and elevated Nt-proBNP (1115 vs. 382 pg/ml, p = 0.002). LA functional parameters inversely correlated with r-ECV (εs r = -0.54; LA-EF r = -0.46; all p < 0.001) and E/e' (εs r = -0.52, LA-EF r = -0.46; all p < 0.006). r-ECV ≥29% and LAVi min >30 ml/m2 have been identified as possible independent factors associated with the endpoint., Conclusions: In HCM diffuse interstitial fibrosis detected by increased r-ECV is associated with LA remodeling and emerged as a potential independent predictor of adverse clinical outcomes, on top of the well-known prognostic impact of LGE., Competing Interests: Declaration of competing interest The authors report no relationships with Industries or other Institutions that could be construed as a conflict of interest related to the present work., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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49. Right ventricular afterload mismatch after transcatheter caval valve implantation for tricuspid regurgitation.
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Gitto M, Jamie G, Figliozzi S, Tartaglia F, Pagliaro BR, Cannata F, and Mangieri A
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- Aged, Humans, Heart Valve Prosthesis, Treatment Outcome, Tricuspid Valve diagnostic imaging, Tricuspid Valve surgery, Tricuspid Valve physiopathology, Ventricular Dysfunction, Right etiology, Ventricular Dysfunction, Right physiopathology, Ventricular Dysfunction, Right diagnostic imaging, Ventricular Function, Right, Cardiac Catheterization adverse effects, Cardiac Catheterization instrumentation, Cardiac Catheterization methods, Heart Valve Prosthesis Implantation adverse effects, Heart Valve Prosthesis Implantation instrumentation, Tricuspid Valve Insufficiency surgery, Tricuspid Valve Insufficiency etiology, Tricuspid Valve Insufficiency physiopathology, Tricuspid Valve Insufficiency diagnostic imaging
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- 2024
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50. Percutaneous suture-based patent foramen ovale closure: A state-of-the-art review.
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Cannata F, Stankowski K, Donia D, Figliozzi S, Fazzari F, Regazzoli D, Reimers B, Bragato RM, Pontone G, Trabattoni D, Colombo A, De Marco F, and Mangieri A
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- Humans, Treatment Outcome, Risk Factors, Septal Occluder Device, Patient Selection, Prosthesis Design, Stroke prevention & control, Stroke etiology, Foramen Ovale, Patent diagnostic imaging, Foramen Ovale, Patent therapy, Foramen Ovale, Patent complications, Foramen Ovale, Patent surgery, Cardiac Catheterization instrumentation, Cardiac Catheterization adverse effects, Suture Techniques adverse effects
- Abstract
Percutaneous closure of a patent foramen ovale (PFO), a common variation of interatrial septum anatomy, is a commonly performed procedure in the catheterization laboratory to reduce the risk of recurrent stroke in selected patients and to treat other PFO-related syndromes. In the last twenty years, disc-based devices have represented the armamentarium of the interventional cardiologist; recently, suture-based devices have become an attractive alternative, despite limited data regarding their long-term performance. The present review gives an overview of the current evidence regarding suture-based PFO closure, the device's characteristics, the echocardiographic evaluation of the PFO anatomy, and recommendations for patient selection. A detailed procedural guide is then provided, and potential complications and future developments in the field are discussed., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2024
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- View/download PDF
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