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2. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

Author

Livingston, Gill, Huntley, Jonathan, Liu, Kathy Y, Costafreda, Sergi G, Selbæk, Geir, Alladi, Suvarna, Ames, David, Banerjee, Sube, Burns, Alistair, Brayne, Carol, Fox, Nick C, Ferri, Cleusa P, Gitlin, Laura N, Howard, Robert, Kales, Helen C, Kivimäki, Mika, Larson, Eric B, Nakasujja, Noeline, Rockwood, Kenneth, Samus, Quincy, Shirai, Kokoro, Singh-Manoux, Archana, Schneider, Lon S, Walsh, Sebastian, Yao, Yao, Sommerlad, Andrew, and Mukadam, Naaheed

Published
2024
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3. The WHO Mental Health Gap Action Programme for mental, neurological, and substance use conditions: the new and updated guideline recommendations

Author

Ali, Amza, Assanangkornchai, Sawitri, Brodaty, Henry, Carli, Vladimir, El Chammay, Rabih, Chang, Odille, Collins, Pamela Y, Cuijpers, Pim, Dowrick, Christopher, Eaton, Julian, Ferri, Cleusa P, Fortes, Sandra, Hengartner, Michael P, Humayun, Asma, Jette, Nathalie, de Vries, Petrus J, Medina-Mora, Maria Elena, Murthy, Pratima, Nadera, Dinah, Newton, Charles, Njenga, Michael, Omigbodun, Olayinka, Rahimi-Movaghar, Afarin, Rahman, Atif, Fortunato dos Santos, Palmira, Saxena, Shekhar, Vijayakumar, Lakshmi, Wang, Huali, Wattanavitukul, Pichayanan, Yewnetu, Enat, Carswell, Ken, Chatterjee, Sudipto, Fatima, Batool, Fleischmann, Alexandra, Gray, Brandon, Hanlon, Charlotte, Hanna, Fahmy, Krupchanka, Dzmitry, Malik, Aiysha, van Ommeren, Mark, Poznyak, Vladimir, Seeher, Katrin, Servili, Chiara, Weissbecker, Inka, Baingana, Florence, Alfonzo Bello, Luis, Bruni, Andrea, Jorge Dos Santos Ferreira Borges Bigot, Ana Carina, Dorji, Chencho, Vandendyck, Martin, Lazeri, Ledia, Monteiro, Maristela Goldnadel, Rani, Manju, Saeed, Khalid, e Souza, Renato Oliveira, Ameyan, Wole, Baltag, Valentina, Branca, Francesco, Cappello, Bernadette, Cometto, Giorgio, Dalil, Suraya, Gabrielli, Albis, Huttner, Benedikt, Jaramillo, Ernesto, Khan, Taskeen, King, Jonathan, Krech, Ruediger, Roebbel, Nathalie, Tran, Nhan, Sumi, Yuka, Brohan, Elaine, Chowdhary, Neerja, Dua, Tarun, Barbui, Corrado, Thornicroft, Graham, and Kestel, Dévora

Published
2024
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5. Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study.

Author

Lipnicki, Darren M, Makkar, Steve R, Crawford, John D, Thalamuthu, Anbupalam, Kochan, Nicole A, Lima-Costa, Maria Fernanda, Castro-Costa, Erico, Ferri, Cleusa Pinheiro, Brayne, Carol, Stephan, Blossom, Llibre-Rodriguez, Juan J, Llibre-Guerra, Jorge J, Valhuerdi-Cepero, Adolfo J, Lipton, Richard B, Katz, Mindy J, Derby, Carol A, Ritchie, Karen, Ancelin, Marie-Laure, Carrière, Isabelle, Scarmeas, Nikolaos, Yannakoulia, Mary, Hadjigeorgiou, Georgios M, Lam, Linda, Chan, Wai-Chi, Fung, Ada, Guaita, Antonio, Vaccaro, Roberta, Davin, Annalisa, Kim, Ki Woong, Han, Ji Won, Suh, Seung Wan, Riedel-Heller, Steffi G, Roehr, Susanne, Pabst, Alexander, van Boxtel, Martin, Köhler, Sebastian, Deckers, Kay, Ganguli, Mary, Jacobsen, Erin P, Hughes, Tiffany F, Anstey, Kaarin J, Cherbuin, Nicolas, Haan, Mary N, Aiello, Allison E, Dang, Kristina, Kumagai, Shuzo, Chen, Tao, Narazaki, Kenji, Ng, Tze Pin, Gao, Qi, Nyunt, Ma Shwe Zin, Scazufca, Marcia, Brodaty, Henry, Numbers, Katya, Trollor, Julian N, Meguro, Kenichi, Yamaguchi, Satoshi, Ishii, Hiroshi, Lobo, Antonio, Lopez-Anton, Raul, Santabárbara, Javier, Leung, Yvonne, Lo, Jessica W, Popovic, Gordana, Sachdev, Perminder S, and for Cohort Studies of Memory in an International Consortium (COSMIC)

Subjects
for Cohort Studies of Memory in an International Consortium, Humans, Diabetes Mellitus, Exercise, Risk Assessment, Risk Factors, Smoking, Cognition, Age Factors, Comorbidity, Health Education, Aged, Aged, 80 and over, Middle Aged, Ethnic Groups, Female, Male, Stroke, Cognitive Dysfunction, and over, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundWith no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups.Methods and findingsWe harmonized longitudinal data from 20 population-based cohorts from 15 countries over 5 continents, including 48,522 individuals (58.4% women) aged 54-105 (mean = 72.7) years and without dementia at baseline. Studies had 2-15 years of follow-up. The risk factors investigated were age, sex, education, alcohol consumption, anxiety, apolipoprotein E ε4 allele (APOE*4) status, atrial fibrillation, blood pressure and pulse pressure, body mass index, cardiovascular disease, depression, diabetes, self-rated health, high cholesterol, hypertension, peripheral vascular disease, physical activity, smoking, and history of stroke. Associations with risk factors were determined for a global cognitive composite outcome (memory, language, processing speed, and executive functioning tests) and Mini-Mental State Examination score. Individual participant data meta-analyses of multivariable linear mixed model results pooled across cohorts revealed that for at least 1 cognitive outcome, age (B = -0.1, SE = 0.01), APOE*4 carriage (B = -0.31, SE = 0.11), depression (B = -0.11, SE = 0.06), diabetes (B = -0.23, SE = 0.10), current smoking (B = -0.20, SE = 0.08), and history of stroke (B = -0.22, SE = 0.09) were independently associated with poorer cognitive performance (p < 0.05 for all), and higher levels of education (B = 0.12, SE = 0.02) and vigorous physical activity (B = 0.17, SE = 0.06) were associated with better performance (p < 0.01 for both). Age (B = -0.07, SE = 0.01), APOE*4 carriage (B = -0.41, SE = 0.18), and diabetes (B = -0.18, SE = 0.10) were independently associated with faster cognitive decline (p < 0.05 for all). Different effects between Asian people and white people included stronger associations for Asian people between ever smoking and poorer cognition (group by risk factor interaction: B = -0.24, SE = 0.12), and between diabetes and cognitive decline (B = -0.66, SE = 0.27; p < 0.05 for both). Limitations of our study include a loss or distortion of risk factor data with harmonization, and not investigating factors at midlife.ConclusionsThese results suggest that education, smoking, physical activity, diabetes, and stroke are all modifiable factors associated with cognitive decline. If these factors are determined to be causal, controlling them could minimize worldwide levels of cognitive decline. However, any global prevention strategy may need to consider ethno-regional differences.

Published
2019

7. The WHO Mental Health Gap Action Programme for mental, neurological, and substance use conditions : the new and updated guideline recommendations

Author

Brohan, Elaine, Chowdhary, Neerja, Dua, Tarun, Barbui, Corrado, Thornicroft, Graham, Kestel, Dévora, Ali, Amza, Assanangkornchai, Sawitri, Brodaty, Henry, Carli, Vladimir, El Chammay, Rabih, Chang, Odille, Collins, Pamela Y., Cuijpers, Pim, Dowrick, Christopher, Eaton, Julian, Ferri, Cleusa P., Fortes, Sandra, Hengartner, Michael P., Humayun, Asma, Jette, Nathalie, de Vries, Petrus J., Medina-Mora, Maria Elena, Murthy, Pratima, Nadera, Dinah, Newton, Charles, Njenga, Michael, Omigbodun, Olayinka, Rahimi-Movaghar, Afarin, Rahman, Atif, Fortunato dos Santos, Palmira, Saxena, Shekhar, Vijayakumar, Lakshmi, Wang, Huali, Wattanavitukul, Pichayanan, Yewnetu, Enat, Carswell, Ken, Chatterjee, Sudipto, Fatima, Batool, Fleischmann, Alexandra, Gray, Brandon, Hanlon, Charlotte, Hanna, Fahmy, Krupchanka, Dzmitry, Malik, Aiysha, van Ommeren, Mark, Poznyak, Vladimir, Seeher, Katrin, Servili, Chiara, Weissbecker, Inka, Baingana, Florence, Alfonzo Bello, Luis, Bruni, Andrea, Jorge Dos Santos Ferreira Borges Bigot, Ana Carina, Dorji, Chencho, Vandendyck, Martin, Lazeri, Ledia, Monteiro, Maristela Goldnadel, Rani, Manju, Saeed, Khalid, e Souza, Renato Oliveira, Ameyan, Wole, Baltag, Valentina, Branca, Francesco, Cappello, Bernadette, Cometto, Giorgio, Dalil, Suraya, Gabrielli, Albis, Huttner, Benedikt, Jaramillo, Ernesto, Khan, Taskeen, King, Jonathan, Krech, Ruediger, Roebbel, Nathalie, Tran, Nhan, Sumi, Yuka, Syed, Shams, Brohan, Elaine, Chowdhary, Neerja, Dua, Tarun, Barbui, Corrado, Thornicroft, Graham, Kestel, Dévora, Ali, Amza, Assanangkornchai, Sawitri, Brodaty, Henry, Carli, Vladimir, El Chammay, Rabih, Chang, Odille, Collins, Pamela Y., Cuijpers, Pim, Dowrick, Christopher, Eaton, Julian, Ferri, Cleusa P., Fortes, Sandra, Hengartner, Michael P., Humayun, Asma, Jette, Nathalie, de Vries, Petrus J., Medina-Mora, Maria Elena, Murthy, Pratima, Nadera, Dinah, Newton, Charles, Njenga, Michael, Omigbodun, Olayinka, Rahimi-Movaghar, Afarin, Rahman, Atif, Fortunato dos Santos, Palmira, Saxena, Shekhar, Vijayakumar, Lakshmi, Wang, Huali, Wattanavitukul, Pichayanan, Yewnetu, Enat, Carswell, Ken, Chatterjee, Sudipto, Fatima, Batool, Fleischmann, Alexandra, Gray, Brandon, Hanlon, Charlotte, Hanna, Fahmy, Krupchanka, Dzmitry, Malik, Aiysha, van Ommeren, Mark, Poznyak, Vladimir, Seeher, Katrin, Servili, Chiara, Weissbecker, Inka, Baingana, Florence, Alfonzo Bello, Luis, Bruni, Andrea, Jorge Dos Santos Ferreira Borges Bigot, Ana Carina, Dorji, Chencho, Vandendyck, Martin, Lazeri, Ledia, Monteiro, Maristela Goldnadel, Rani, Manju, Saeed, Khalid, e Souza, Renato Oliveira, Ameyan, Wole, Baltag, Valentina, Branca, Francesco, Cappello, Bernadette, Cometto, Giorgio, Dalil, Suraya, Gabrielli, Albis, Huttner, Benedikt, Jaramillo, Ernesto, Khan, Taskeen, King, Jonathan, Krech, Ruediger, Roebbel, Nathalie, Tran, Nhan, Sumi, Yuka, and Syed, Shams

Abstract

The WHO Mental Health Gap Action Programme (mhGAP) guideline update reflects 15 years of investment in reducing the treatment gap and scaling up care for people with mental, neurological, and substance use (MNS) conditions. It was produced by a guideline development group and steering group, with support from topic experts, using quantitative and qualitative evidence and a systematic review of use of mhGAP. 90 recommendations from the 2015 guideline update were validated and endorsed for use in their current format. These are joined by 30 revised recommendations and 18 new recommendations, including a new module on anxiety. Psychological interventions are emphasised as treatments and digitally delivered interventions feature across many modules, as well as updated recommendations for psychotropic medicines. Research gaps identified include the need for evidence from low-resource settings and on the views of people with lived experience of MNS conditions. The revised recommendations ensure that mhGAP continues to offer high-quality, timely, transparent, and evidence-based guidance to support non-specialist health workers in low-income and middle-income countries in providing care to individuals with MNS conditions.

Published
2024

8. Association of Moderate and Vigorous Physical Activity With Cognitive Performance: Evidence From Brazil.

Author

de Pais, Ingryd Mayara Nascimento Martins, Rabelo, Wendell Lima, Ferreira, Naomi Vidal, Ferri, Cleusa Pinheiro, Suemoto, Claudia Kimie, and Gonçalves, Natalia Gomes

Abstract

Objective: It is estimated that 2% of dementia cases worldwide could be prevented with increases in physical activity. However, there is little evidence of the association between vigorous physical activity (VPA) and cognitive performance. This study aimed to investigate the association of moderate physical activity (MPA) and VPA with cognitive performance in older adults fromthe Brazilian Longitudinal Study of Aging (ELSI-Brasil). Patients and Methods: Data from 7954 participants were analyzed. Mean age was 61.8 ± 9.2 years, 61.8% were women, and 44.3% were mixed races. Cognitive performance evaluated the memory, temporal orientation, and verbal fluency domains. A global composite z-score was derived from the tests. Physical activity was assessed by self-report. We used linear regression models to verify the association of MPA and VPA with cognitive performance. Results: Compared with participants who did not meet the guidelines for MPA (<150min/wk), those who met the guidelines (150 to 299min/wk) and those who performed more than 2x the recommended amount of MPA (300min or more/wk) had better global cognitive performance (β = 0.163, 95%CI = 0.086, 0.241; P < 0.001; β = 0.180, 95% CI = 0.107, 0.253, P < 0.001, respectively). We found no association between VPA and cognitive performance. Conclusion: There was no additional benefit of VPA for cognitive performance. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Online Cognitive Stimulation Therapy for dementia in Brazil and India: Acceptability, Feasibility and Lessons for Implementation (Preprint)

Author

Fisher, Emily, primary, Venkatesan, Shreenila, additional, Benevides, Pedro, additional, Bertrand, Elodie, additional, Brum, Paula Schimidt, additional, El Baou, Céline, additional, Ferri, Cleusa P., additional, Fossey, Jane, additional, Jelen, Maria, additional, Laks, Jerson, additional, Liu, Lisa, additional, Mograbi, Daniel C., additional, Natarajan, Nirupama, additional, Naylor, Renata, additional, Pantouli, Despina, additional, Ramanujam, Vaishnavi, additional, Rangaswamy, Thara, additional, Santos de Carvalho, Raquel L., additional, Stoner, Charlotte, additional, Vaitheswaran, Sridhar, additional, and Spector, Aimee, additional

Published
2023
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10. The dementia severity rating scale: A potential community screening tool for dementia in low- and middle-income countries

Author

Turana, Yuda, primary, Farina, Nicolas, additional, Theresia, Imelda, additional, Fitri, Fasihah Irfani, additional, Suswanti, Ika, additional, Jacobs, Roxanne, additional, Schneider, Marguerite, additional, Sani, Tara Puspitarini, additional, Comas-Herrera, Adelina, additional, Albanese, Emiliano, additional, Govia, Ishtar, additional, Ferri, Cleusa P, additional, Knapp, Martin, additional, and Banerjee, Sube, additional

Published
2023
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11. Virtual Cognitive Stimulation Therapy for dementia: The development, feasibility and initial outcomes of a global framework

Author

Spector, Aimee E, primary, Perkins, Luke, additional, Fisher, Emily, additional, Felstead, Cerne, additional, Wong, Gloria HY, additional, Dai, Ruizhi, additional, Vaitheswaran, Sridhar, additional, Natarajan, Nirupama, additional, Venkatesan, Shreenila, additional, Mograbi, Daniel C., additional, Ferri, Cleusa P, additional, Santos, Raquel L, additional, and Stott, Joshua, additional

Published
2023
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18. International implementation of Cognitive Stimulation Therapy in Brazil, India and Tanzania: Findings from the CST‐International study

Author

Fisher, Emily, primary, Mograbi, Daniel C., additional, Ferri, Cleusa P, additional, Santos, Raquel L, additional, Naylor, Renata, additional, Brum, Paula Schimidt, additional, Bertrand, Elodie, additional, Benevides, Pedro, additional, Vaitheswaran, Sridhar, additional, Venkatesan, Shreenila, additional, Natarajan, Nirupama, additional, Krishna, Murali, additional, Chandra, Mina, additional, Shaji, K S, additional, Mkenda, Sarah, additional, Urasa, Sarah, additional, Walker, Richard, additional, Dotchin, Catherine, additional, Paddick, Stella‐Maria, additional, Walker, Jess, additional, Oliver, Benedict, additional, Stoner, Charlotte, additional, and Spector, Aimee E, additional

Published
2023
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21. Dementia prevention, intervention, and care: 2024 report of the Lancetstanding Commission

Author

Livingston, Gill, Huntley, Jonathan, Liu, Kathy Y, Costafreda, Sergi G, Selbæk, Geir, Alladi, Suvarna, Ames, David, Banerjee, Sube, Burns, Alistair, Brayne, Carol, Fox, Nick C, Ferri, Cleusa P, Gitlin, Laura N, Howard, Robert, Kales, Helen C, Kivimäki, Mika, Larson, Eric B, Nakasujja, Noeline, Rockwood, Kenneth, Samus, Quincy, Shirai, Kokoro, Singh-Manoux, Archana, Schneider, Lon S, Walsh, Sebastian, Yao, Yao, Sommerlad, Andrew, and Mukadam, Naaheed

Published
2024
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22. Estimating the number of people living with dementia at different stages of the condition in India: A Delphi process.

Author

Farina, Nicolas, Rajagopalan, Jayeeta, Alladi, Suvarna, Ibnidris, Aliaa, Ferri, Cleusa P, Knapp, Martin, and Comas-Herrera, Adelina

Subjects
CONSENSUS (Social sciences), STATISTICAL models, RESEARCH funding, SEX distribution, AGE distribution, SEVERITY of illness index, DISEASE prevalence, DESCRIPTIVE statistics, DEMENTIA, DELPHI method, COMPARATIVE studies, CONFIDENCE intervals, DEMENTIA patients, HEALTH care rationing, MEDICAL care costs, OLD age
Abstract

Introduction: Numerous studies have previously estimated the dementia prevalence in India. However, as these estimates use different methodologies and sampling strategies, generating definitive prevalence estimates can be difficult. Methods: A Delphi process involving eight clinical and academic experts provided prevalence estimates of dementia within India, split by sex and age. The experts were also asked to estimate the number of people potentially living at different stages of the condition. A priori criteria were used to ascertain the point in which consensus was achieved. Results: Our consensus estimates generated a dementia prevalence of 2.8% (95% CI = 1.9 to 3.6) for those aged 60 years and above in India. Consensus was achieved across age and sex prevalence estimates, with the exception of one (females aged 60–64). Our experts estimated that 42.9% of people living with dementia in India had a mild severity. Conclusions: The findings indicate that there could be approximately 3.9 million people living with dementia in India, of which 1.7 million could be living with dementia of mild severity. Such estimates can better help researchers and policy makers to estimate the true cost and impact of dementia in India and can inform resource allocation decisions. [ABSTRACT FROM AUTHOR]

Published
2024
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23. The dementia severity rating scale: A potential community screening tool for dementia in low- and middle-income countries.

Author

Turana, Yuda, Farina, Nicolas, Theresia, Imelda, Fitri, Fasihah Irfani, Suswanti, Ika, Jacobs, Roxanne, Schneider, Marguerite, Sani, Tara Puspitarini, Comas-Herrera, Adelina, Albanese, Emiliano, Govia, Ishtar, Ferri, Cleusa P, Knapp, Martin, and Banerjee, Sube

Subjects
TREATMENT of dementia, MIDDLE-income countries, RESEARCH funding, HUMAN beings, STATISTICAL sampling, SEVERITY of illness index, DESCRIPTIVE statistics, PSYCHOMETRICS, CONFIDENCE intervals, LOW-income countries, ALGORITHMS, SENSITIVITY & specificity (Statistics)
Abstract

Background: The Dementia Severity Rating Scale (DSRS) is an informant report, dementia staging tool that is quick to administer and has previous been shown to differentiate between people with dementia and healthy controls. However, it is not clear how accurate the tool is screening against diagnostic criteria in middle-income settings. Methods: Embedded within the STRiDE programme, older adults (aged ≥65 years) and their informants were randomly recruited from four sites across Indonesia and South Africa. All informants were asked to complete DSRS. We report the tool's psychometric properties and accuracy against the 10/66 short diagnostic algorithm. Results: Between September and December 2021, data was collected from 2110 older adults in Indonesia and 408 in South Africa. Overall, the DSRS scores significantly differed between those with and without dementia, as identified on the 10/66 short algorithm (p <.05). The difference between groups remained significant after controlling for key factors related to older adult and informant demographics. A score >2 on the DSRS had the greatest agreement with the 10/66 short algorithm and had excellent discriminative properties in both Indonesia (Area Under Curve (AUC) =.75, 95% CIs =.72–.77) and South Africa (AUC =.82, 95% CIs =.76–.88). Conclusions: The DSRS has potential as a screening tool for dementia in middle-income countries, with high sensitivity and specificity against a standardized diagnostic algorithm. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Accessing Dementia Care in Brazil: An Analysis of Case Vignettes.

Author

Figueiredo Da Mata, Fabiana Araújo, Oliveira, Déborah, Mateus, Elaine, Franzon, Ana Carolina Arruda, Godoy, Carolina, Salcher-Konrad, Maximilian, De-Poli, Chiara, Comas-Herrera, Adelina, Ferri, Cleusa P, and Lorenz-Dant, Klara

Subjects
TREATMENT of dementia, HEALTH services accessibility, RESEARCH funding, SOCIOECONOMIC factors, CAREGIVERS, SOCIAL support, CASE studies
Abstract

Background and Objectives: Despite the rapid increase in the number of people living with dementia in Brazil, dementia care is limited. This study describes how people living with dementia and their carers access care, treatment, and support, and identifies what characteristics are likely to enable or prevent access. Research Design and Methods: We created 10 vignettes to illustrate fictitious but realistic scenarios involving people living with dementia in Brazil. The vignettes explore a combination of socioeconomic and demographic variables. They were completed using an in-depth desk review of the dementia care landscape in Brazil; a Strengths, Opportunities, Weaknesses, and Threats (SWOT) analysis of the desk review; and expert knowledge. The analysis focused on identifying common sources of service provision, barriers of access to care and support, and specific issues experienced by some population groups. Findings: Access to a dementia diagnosis, care, and support for people living with dementia in Brazil is limited. Demographic and socio-economic circumstances play a role in determining the type of services to which a person might have access. Poor knowledge about dementia, lack of capacity in the health system, and lack of formal long-term care support are among the identified barriers to accessing timely diagnosis, care, and support in the country. Discussion and Implications: Understanding the barriers and facilitators of access to diagnosis, treatment, and support for people with dementia and families with different demographic and socioeconomic characteristics is crucial for designing dementia policies that are context-specific and responsive to the care needs of different socioeconomic groups in Brazil. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Comprehensive measurement of the prevalence of dementia in low- and middle-income countries: STRiDE methodology and its application in Indonesia and South Africa

Author

Farina, Nicolas, primary, Jacobs, Roxanne, additional, Turana, Yuda, additional, Fitri, Fasihah Irfani, additional, Schneider, Marguerite, additional, Theresia, Imelda, additional, Docrat, Sumaiyah, additional, Sani, Tara Puspitarini, additional, Augustina, Lydia, additional, Albanese, Emiliano, additional, Comas-Herrera, Adelina, additional, Du Toit, Petra, additional, Ferri, Cleusa P., additional, Govia, Ishtar, additional, Ibnidris, Aliaa, additional, Knapp, Martin, additional, and Banerjee, Sube, additional

Published
2023
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29. Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging

Author

Gouveia, Mateus H., Cesar, Cibele C., Santolalla, Meddly L., Anna, Hanaisa P. Sant, Scliar, Marilia O., Leal, Thiago P., Araújo, Nathalia M., Soares-Souza, Giordano B., Magalhães, Wagner C. S., Mata, Ignacio F., Ferri, Cleusa P., Castro-Costa, Erico, Mbulaiteye, Sam M., Tishkoff, Sarah A., Shriner, Daniel, Rotimi, Charles N., Tarazona-Santos, Eduardo, and Lima-Costa, Maria Fernanda

Published
2019
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30. Comprehensive measurement of the prevalence of dementia in low- and middle-income countries: STRiDE methodology and its application in Indonesia and South Africa

Author

Farina, Nicolas, Jacobs, Roxanne, Turana, Yuda, Fitri, Fasihah Irfani, Schneider, Marguerite, Theresia, Imelda, Docrat, Sumaiyah, Sani, Tara Puspitarini, Augustina, Lydia, Albanese, Emiliano, Comas-Herrera, Adelina, Du Toit, Petra, Ferri, Cleusa P., Govia, Ishtar, Ibnidris, Aliaa, Knapp, Martin, and Banerjee, Sube

Subjects
RA0421 Public health. Hygiene. Preventive Medicine, HA Statistics, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Abstract

Background A core element of the Strengthening Responses to Dementia in Developing Countries (STRiDE) programme was to generate novel data on the prevalence, cost and impact of dementia in low- and middle-income countries, to build better health policy. Indonesia and South Africa are two middle-income countries in need of such data. Aims To present the STRiDE methodology and generate estimates of dementia prevalence in Indonesia and South Africa. Method We conducted community-based, single-phase, cross-sectional studies in Indonesia and South Africa, randomly sampling participants aged 65 years or older in each country. Dementia prevalence rates for each country were generated by using the 10/66 short schedule and applying its diagnostic algorithm. Weighted estimates were calculated with national sociodemographic data. Results Data were collected between September and December 2021 in 2110 people in Indonesia and 408 people in South Africa. The adjusted weighted dementia prevalence was 27.9% (95% CI 25.2-28.9) in Indonesia and 12.5% (95% CI 9.5-16.0) in South Africa. Our results indicate that there could be >4.2 million people in Indonesia and >450 000 people in South Africa who have dementia. Only five participants (0.2%) in Indonesia and two (0.5%) in South Africa had been previously diagnosed with dementia. Conclusions Despite prevalence estimates being high, formal diagnosis rates of dementia were very low across both countries (

Published
2023

31. Estimating the number of people living with dementia at different stages of the condition in India: a Delphi process

Author

Farina, Nicolas, Rajagopalan, Jayeeta, Alladi, Suvarna, Ibnidris, Aliaa, Ferri, Cleusa P., Knapp, Martin, and Comas-Herrera, Adelina

Subjects
RA0421 Public health. Hygiene. Preventive Medicine
Abstract

Introduction: Numerous studies have previously estimated the dementia prevalence in India. However, as these estimates use different methodologies and sampling strategies, generating definitive prevalence estimates can be difficult. Methods: A Delphi process involving eight clinical and academic experts provided prevalence estimates of dementia within India, split by sex and age. The experts were also asked to estimate the number of people potentially living at different stages of the condition. A priori criteria were used to ascertain the point in which consensus was achieved. Results: Our consensus estimates generated a dementia prevalence of 2.8% (95% CI = 1.9 to 3.6) for those aged 60 years and above in India. Consensus was achieved across age and sex prevalence estimates, with the exception of one (females aged 60-64). Our experts estimated that 42.9% of people living with dementia in India had a mild severity. Conclusions: The findings indicate that there could be approximately 3.9 million people living with dementia in India, of which 1.7 million could be living with dementia of mild severity. Such estimates can better help researchers and policy makers to estimate the true cost and impact of dementia in India and can inform resource allocation decisions.

Published
2023

33. Accessing Dementia Care in Brazil: An Analysis of Case Vignettes

Author

Figueiredo Da Mata, Fabiana Araújo, primary, Oliveira, Déborah, additional, Mateus, Elaine, additional, Franzon, Ana Carolina Arruda, additional, Godoy, Carolina, additional, Salcher-Konrad, Maximilian, additional, De-Poli, Chiara, additional, Comas-Herrera, Adelina, additional, Ferri, Cleusa P, additional, and Lorenz-Dant, Klara, additional

Published
2023
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36. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

Author

Forouzanfar, Mohammad H, Alexander, Lily, Anderson, H Ross, Bachman, Victoria F, Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M, Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J, KC, Astha, Kyu, Hmwe H, Moradi-Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A, Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Ozgoren, Ayse Abbasoglu, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu-Rmeileh, Niveen M E, Aburto, Tania C, Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Al Khabouri, Mazin J, Al Lami, Faris H, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, François, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Cunningham, Solveig Argeseanu, Arnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charles, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Ruvalcaba, Carolina Batis, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bikbov, Boris, Abdulhak, Aref A Bin, Blore, Jed D, Blyth, Fiona M, Bohensky, Megan A, Başara, Berrak Bora, Borges, Guilherme, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J, Brenner, Hermann, Briggs, Adam D M, Broday, David M, Brooks, Peter M, Bruce, Nigel G, Brugha, Traolach S, Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N, Bukhman, Gene, Bulloch, Andrew G, Burch, Michael, Burney, Peter G J, Campos-Nonato, Ismael R, Campuzano, Julio C, Cantoral, Alejandra J, Caravanos, Jack, Cárdenas, Rosario, Cardis, Elisabeth, Carpenter, David O, Caso, Valeria, Castañeda-Orjuela, Carlos A, Castro, Ruben E, Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K, Chang, Jung-chen, Charlson, Fiona J, Chen, Honglei, Chen, Wanqing, Chen, Zhengming, Chiang, Peggy P, Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christophi, Costas A, Chuang, Ting-Wu, Chugh, Sumeet S, Cirillo, Massimo, Claßen, Thomas KD, Colistro, Valentina, Colomar, Mercedes, Colquhoun, Samantha M, Contreras, Alejandra G, Cooper, Cyrus, Cooperrider, Kimberly, Cooper, Leslie T, Coresh, Josef, Courville, Karen J, Criqui, Michael H, Cuevas-Nasu, Lucia, Damsere-Derry, James, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Davis, Adrian, Davitoiu, Dragos V, Dayama, Anand, de Castro, E Filipa, De la Cruz-Góngora, Vanessa, De Leo, Diego, de Lima, Graça, Degenhardt, Louisa, del Pozo-Cruz, Borja, Dellavalle, Robert P, Deribe, Kebede, Derrett, Sarah, Jarlais, Don C Des, Dessalegn, Muluken, deVeber, Gabrielle A, Devries, Karen M, Dharmaratne, Samath D, Dherani, Mukesh K, Dicker, Daniel, Ding, Eric L, Dokova, Klara, Dorsey, E Ray, Driscoll, Tim R, Duan, Leilei, Durrani, Adnan M, Ebel, Beth E, Ellenbogen, Richard G, Elshrek, Yousef M, Endres, Matthias, Ermakov, Sergey P, Erskine, Holly E, Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Faraon, Emerito Jose A, Farzadfar, Farshad, Fay, Derek F J, Feigin, Valery L, Feigl, Andrea B, Fereshtehnejad, Seyed-Mohammad, Ferrari, Alize J, Ferri, Cleusa P, Flaxman, Abraham D, Fleming, Thomas D, Foigt, Nataliya, Foreman, Kyle J, Paleo, Urbano Fra, Franklin, Richard C, Gabbe, Belinda, Gaffikin, Lynne, Gakidou, Emmanuela, Gamkrelidze, Amiran, Gankpé, Fortuné G, Gansevoort, Ron T, García-Guerra, Francisco A, Gasana, Evariste, Geleijnse, Johanna M, Gessner, Bradford D, Gething, Pete, Gibney, Katherine B, Gillum, Richard F, Ginawi, Ibrahim A M, Giroud, Maurice, Giussani, Giorgia, Goenka, Shifalika, Goginashvili, Ketevan, Dantes, Hector Gomez, Gona, Philimon, de Cosio, Teresita Gonzalez, González-Castell, Dinorah, Gotay, Carolyn C, Goto, Atsushi, Gouda, Hebe N, Guerrant, Richard L, Gugnani, Harish C, Guillemin, Francis, Gunnell, David, Gupta, Rahul, Gupta, Rajeev, Gutiérrez, Reyna A, Hafezi-Nejad, Nima, Hagan, Holly, Hagstromer, Maria, Halasa, Yara A, Hamadeh, Randah R, Hammami, Mouhanad, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Haregu, Tilahun Nigatu, Haro, Josep Maria, Havmoeller, Rasmus, Hay, Simon I, Hedayati, Mohammad T, Heredia-Pi, Ileana B, Hernandez, Lucia, Heuton, Kyle R, Heydarpour, Pouria, Hijar, Martha, Hoek, Hans W, Hoffman, Howard J, Hornberger, John C, Hosgood, H Dean, Hoy, Damian G, Hsairi, Mohamed, Hu, Guoqing, Hu, Howard, Huang, Cheng, Huang, John J, Hubbell, Bryan J, Huiart, Laetitia, Husseini, Abdullatif, Iannarone, Marissa L, Iburg, Kim M, Idrisov, Bulat T, Ikeda, Nayu, Innos, Kaire, Inoue, Manami, Islami, Farhad, Ismayilova, Samaya, Jacobsen, Kathryn H, Jansen, Henrica A, Jarvis, Deborah L, Jassal, Simerjot K, Jauregui, Alejandra, Jayaraman, Sudha, Jeemon, Panniyammakal, Jensen, Paul N, Jha, Vivekanand, Jiang, Fan, Jiang, Guohong, Jiang, Ying, Jonas, Jost B, Juel, Knud, Kan, Haidong, Roseline, Sidibe S Kany, Karam, Nadim E, Karch, André, Karema, Corine K, Karthikeyan, Ganesan, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S, Kemp, Andrew H, Kengne, Andre P, Keren, Andre, Khader, Yousef S, Khalifa, Shams Eldin Ali Hassan, Khan, Ejaz A, Khang, Young-Ho, Khatibzadeh, Shahab, Khonelidze, Irma, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kim, Yunjin, Kimokoti, Ruth W, Kinfu, Yohannes, Kinge, Jonas M, Kissela, Brett M, Kivipelto, Miia, Knibbs, Luke D, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kose, M Rifat, Kosen, Soewarta, Kraemer, Alexander, Kravchenko, Michael, Krishnaswami, Sanjay, Kromhout, Hans, Ku, Tiffany, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kuipers, Ernst J, Kulkarni, Chanda, Kulkarni, Veena S, Kumar, G Anil, Kwan, Gene F, Lai, Taavi, Balaji, Arjun Lakshmana, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lan, Qing, Lansingh, Van C, Larson, Heidi J, Larsson, Anders, Laryea, Dennis O, Lavados, Pablo M, Lawrynowicz, Alicia E, Leasher, Janet L, Lee, Jong-Tae, Leigh, James, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liang, Xiaofeng, Lim, Stephen S, Lindsay, M Patrice, Lipshultz, Steven E, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Logroscino, Giancarlo, London, Stephanie J, Lopez, Nancy, Lortet-Tieulent, Joannie, Lotufo, Paulo A, Lozano, Rafael, Lunevicius, Raimundas, Ma, Jixiang, Ma, Stefan, Machado, Vasco M P, MacIntyre, Michael F, Magis-Rodriguez, Carlos, Mahdi, Abbas A, Majdan, Marek, Malekzadeh, Reza, Mangalam, Srikanth, Mapoma, Christopher C, Marape, Marape, Marcenes, Wagner, Margolis, David J, Margono, Christopher, Marks, Guy B, Martin, Randall V, Marzan, Melvin B, Mashal, Mohammad T, Masiye, Felix, Mason-Jones, Amanda J, Matsushita, Kunihiro, Matzopoulos, Richard, Mayosi, Bongani M, Mazorodze, Tasara T, McKay, Abigail C, McKee, Martin, McLain, Abigail, Meaney, Peter A, Medina, Catalina, Mehndiratta, Man Mohan, Mejia-Rodriguez, Fabiola, Mekonnen, Wubegzier, Melaku, Yohannes A, Meltzer, Michele, Memish, Ziad A, Mendoza, Walter, Mensah, George A, Meretoja, Atte, Mhimbira, Francis Apolinary, Micha, Renata, Miller, Ted R, Mills, Edward J, Misganaw, Awoke, Mishra, Santosh, Ibrahim, Norlinah Mohamed, Mohammad, Karzan A, Mokdad, Ali H, Mola, Glen L, Monasta, Lorenzo, Hernandez, Julio C Montañez, Montico, Marcella, Moore, Ami R, Morawska, Lidia, Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N, Mozaffarian, Dariush, Mueller, Ulrich O, Mukaigawara, Mitsuru, Mullany, Erin C, Murthy, Kinnari S, Naghavi, Mohsen, Nahas, Ziad, Naheed, Aliya, Naidoo, Kovin S, Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, KM Venkat, Nash, Denis, Neal, Bruce, Nejjari, Chakib, Neupane, Sudan P, Newton, Charles R, Ngalesoni, Frida N, de Dieu Ngirabega, Jean, Nguyen, Grant, Nguyen, Nhung T, Nieuwenhuijsen, Mark J, Nisar, Muhammad I, Nogueira, José R, Nolla, Joan M, Nolte, Sandra, Norheim, Ole F, Norman, Rosana E, Norrving, Bo, Nyakarahuka, Luke, Oh, In-Hwan, Ohkubo, Takayoshi, Olusanya, Bolajoko O, Omer, Saad B, Opio, John Nelson, Orozco, Ricardo, Pagcatipunan, Rodolfo S, Jr., Pain, Amanda W, Pandian, Jeyaraj D, Panelo, Carlo Irwin A, Papachristou, Christina, Park, Eun-Kee, Parry, Charles D, Caicedo, Angel J Paternina, Patten, Scott B, Paul, Vinod K, Pavlin, Boris I, Pearce, Neil, Pedraza, Lilia S, Pedroza, Andrea, Stokic, Ljiljana Pejin, Pekericli, Ayfer, Pereira, David M, Perez-Padilla, Rogelio, Perez-Ruiz, Fernando, Perico, Norberto, Perry, Samuel A L, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B, Petzold, Max, Phillips, Michael R, Phua, Hwee Pin, Plass, Dietrich, Poenaru, Dan, Polanczyk, Guilherme V, Polinder, Suzanne, Pond, Constance D, Pope, C Arden, Pope, Daniel, Popova, Svetlana, Pourmalek, Farshad, Powles, John, Prabhakaran, Dorairaj, Prasad, Noela M, Qato, Dima M, Quezada, Amado D, Quistberg, D Alex A, Racapé, Lionel, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Sajjad Ur, Raju, Murugesan, Rakovac, Ivo, Rana, Saleem M, Rao, Mayuree, Razavi, Homie, Reddy, K Srinath, Refaat, Amany H, Rehm, Jürgen, Remuzzi, Giuseppe, Ribeiro, Antonio L, Riccio, Patricia M, Richardson, Lee, Riederer, Anne, Robinson, Margaret, Roca, Anna, Rodriguez, Alina, Rojas-Rueda, David, Romieu, Isabelle, Ronfani, Luca, Room, Robin, Roy, Nobhojit, Ruhago, George M, Rushton, Lesley, Sabin, Nsanzimana, Sacco, Ralph L, Saha, Sukanta, Sahathevan, Ramesh, Sahraian, Mohammad Ali, Salomon, Joshua A, Salvo, Deborah, Sampson, Uchechukwu K, Sanabria, Juan R, Sanchez, Luz Maria, Sánchez-Pimienta, Tania G, Sanchez-Riera, Lidia, Sandar, Logan, Santos, Itamar S, Sapkota, Amir, Satpathy, Maheswar, Saunders, James E, Sawhney, Monika, Saylan, Mete I, Scarborough, Peter, Schmidt, Jürgen C, Schneider, Ione J C, Schöttker, Ben, Schwebel, David C, Scott, James G, Seedat, Soraya, Sepanlou, Sadaf G, Serdar, Berrin, Servan-Mori, Edson E, Shaddick, Gavin, Shahraz, Saeid, Levy, Teresa Shamah, Shangguan, Siyi, She, Jun, Sheikhbahaei, Sara, Shibuya, Kenji, Shin, Hwashin H, Shinohara, Yukito, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Sigfusdottir, Inga D, Silberberg, Donald H, Simard, Edgar P, Sindi, Shireen, Singh, Abhishek, Singh, Gitanjali M, Singh, Jasvinder A, Skirbekk, Vegard, Sliwa, Karen, Soljak, Michael, Soneji, Samir, Søreide, Kjetil, Soshnikov, Sergey, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stapelberg, Nicolas J C, Stathopoulou, Vasiliki, Steckling, Nadine, Stein, Dan J, Stein, Murray B, Stephens, Natalie, Stöckl, Heidi, Straif, Kurt, Stroumpoulis, Konstantinos, Sturua, Lela, Sunguya, Bruno F, Swaminathan, Soumya, Swaroop, Mamta, Sykes, Bryan L, Tabb, Karen M, Takahashi, Ken, Talongwa, Roberto T, Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Te Ao, Braden J, Teixeira, Carolina M, Téllez Rojo, Martha M, Terkawi, Abdullah S, Texcalac-Sangrador, José Luis, Thackway, Sarah V, Thomson, Blake, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tillmann, Taavi, Tobollik, Myriam, Tonelli, Marcello, Topouzis, Fotis, Towbin, Jeffrey A, Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X, Trasande, Leonardo, Trillini, Matias, Trujillo, Ulises, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadis, Tuzcu, Emin Murat, Uchendu, Uche S, Ukwaja, Kingsley N, Uzun, Selen B, van de Vijver, Steven, Van Dingenen, Rita, van Gool, Coen H, van Os, Jim, Varakin, Yuri Y, Vasankari, Tommi J, Vasconcelos, Ana Maria N, Vavilala, Monica S, Veerman, Lennert J, Velasquez-Melendez, Gustavo, Venketasubramanian, N, Vijayakumar, Lakshmi, Villalpando, Salvador, Violante, Francesco S, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R, Waller, Stephen G, Wallin, Mitchell T, Wan, Xia, Wang, Haidong, Wang, JianLi, Wang, Linhong, Wang, Wenzhi, Wang, Yanping, Warouw, Tati S, Watts, Charlotte H, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Wessells, K Ryan, Westerman, Ronny, Whiteford, Harvey A, Wilkinson, James D, Williams, Hywel C, Williams, Thomas N, Woldeyohannes, Solomon M, Wolfe, Charles D A, Wong, John Q, Woolf, Anthony D, Wright, Jonathan L, Wurtz, Brittany, Xu, Gelin, Yan, Lijing L, Yang, Gonghuan, Yano, Yuichiro, Ye, Pengpeng, Yenesew, Muluken, Yentür, Gökalp K, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Younoussi, Zourkaleini, Yu, Chuanhua, Zaki, Maysaa E, Zhao, Yong, Zheng, Yingfeng, Zhou, Maigeng, Zhu, Jun, Zhu, Shankuan, Zou, Xiaonong, Zunt, Joseph R, Lopez, Alan D, Vos, Theo, and Murray, Christopher J

Published
2015
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39. Supplemental Material - Accessing Dementia Care in Brazil: An Analysis of Case Vignettes

Author

Figueiredo Da Mata, Fabiana Araújo, Oliveira, Déborah, Mateus, Elaine, Franzon, Ana Carolina Arruda, Godoy, Carolina, Salcher-Konrad, Maximilian, De-Poli, Chiara, Comas-Herrera, Adelina, Ferri, Cleusa P, and Lorenz-Dant, Klara

Subjects
111099 Nursing not elsewhere classified, 111708 Health and Community Services, FOS: Clinical medicine, FOS: Political science, FOS: Health sciences, 160512 Social Policy, 110308 Geriatrics and Gerontology
Abstract

Supplemental Material for Accessing Dementia Care in Brazil: An Analysis of Case Vignettes by Fabiana Araújo Figueiredo Da Mata, Deborah Oliveira, Elaine Mateus, Ana Carolina Arruda Franzon, Carolina Godoy, Maximillian Salcher-Konrad, Chiara De Poli, Adelina Comas-Herrera, Cleusa P Ferri, and Klara Lorenz-Dant in Dementia.

Published
2023
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40. Supplemental Material - Estimating the number of people living with dementia at different stages of the condition in India: A Delphi process

Author

Farina, Nicolas, Rajagopalan, Jayeeta, Alladi, Suvarna, Ibnidris, Aliaa, Ferri, Cleusa P, Knapp, Martin, and Comas-Herrera, Adelina

Subjects
111099 Nursing not elsewhere classified, 111708 Health and Community Services, FOS: Clinical medicine, FOS: Political science, FOS: Health sciences, 160512 Social Policy, 110308 Geriatrics and Gerontology
Abstract

Supplemental Material for Estimating the number of people living with dementia at different stages of the condition in India: A Delphi process by Nicolas Farina, Jayeeta Rajagopalan, Suvarna Alladi, Aliaa Ibnidris, Cleusa P Ferri, Martin Knapp, Adelina Comas-Herrera in Dementia

Published
2023
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45. Rationale and Design of the COVID-19 Outpatient Prevention Evaluation (COPE - Coalition V) Randomized Clinical Trial: Hydroxychloroquine vs. Placebo in Non-Hospitalized Patients

Author

Oliveira Junior, Haliton Alves de, Ferri, Cleusa P., Boszczowski, Icaro, Oliveira, Gustavo B. F., Cavalcanti, Alexandre B., Rosa, Regis G., Lopes, Renato D., Azevedo, Luciano C. P., Veiga, Viviane C., Berwanger, Otavio, and Avezum, Álvaro

Subjects
Hidroxicloroquina, Ensaio Clínico Controlado Aleatório, SARS-CoV-2, Randomized Controlled Trial, COVID-19, Hydroxychloroquine
Abstract

Resumo Fundamento Apesar da necessidade de opções terapêuticas específicas para a doença do coronavírus 2019 (covid-19), ainda não há evidências da eficácia de tratamentos específicos no contexto ambulatorial. Há poucos estudos randomizados que avaliam a hidroxicloroquina (HCQ) em pacientes não hospitalizados. Esses estudos não indicaram benefício com o uso da HCQ; no entanto, avaliaram desfechos primários diferentes e apresentaram vieses importantes na avaliação dos desfechos. Objetivo Investigar se a HCQ possui o potencial de prevenir hospitalizações por covid-19 quando comparada ao placebo correspondente. Métodos O estudo COVID-19 Outpatient Prevention Evaluation (COPE) é um ensaio clínico randomizado, pragmático, duplo-cego, multicêntrico e controlado por placebo que avalia o uso da HCQ (800 mg no dia 1 e 400 mg do dia 2 ao dia 7) ou placebo correspondente na prevenção de hospitalizações por covid-19 em casos precoces confirmados ou suspeitos de pacientes não hospitalizados. Os critérios de inclusão são adultos (≥ 18 anos) que procuraram atendimento médico com sintomas leves de covid-19, com randomização ≤ 7 dias após o início dos sintomas, sem indicação de hospitalização na triagem do estudo e com pelo menos um fator de risco para complicações (> 65 anos, hipertensão, diabetes melito, asma, doença pulmonar obstrutiva crônica ou outras doenças pulmonares crônicas, tabagismo, imunossupressão ou obesidade). Todos os testes de hipótese serão bilaterais. Um valor de p < 0,05 será considerado estatisticamente significativo em todas as análises. Clinicaltrials.gov: NCT04466540. Resultados Os desfechos clínicos serão avaliados centralmente por um comitê de eventos clínicos independente cegado para a alocação dos grupos de tratamento. O desfecho primário de eficácia será avaliado de acordo com o princípio da intenção de tratar. Conclusão Este estudo apresenta o potencial de responder de forma confiável a questão científica do uso da HCQ em pacientes ambulatoriais com covid-19. Do nosso conhecimento, este é o maior estudo avaliando o uso de HCQ em indivíduos com covid-19 não hospitalizados. Abstract Background Despite the need for targeting specific therapeutic options for coronavirus disease 2019 (COVID-19), there has been no evidence of effectiveness of any specific treatment for the outpatient clinical setting. There are few randomized studies evaluating hydroxychloroquine (HCQ) in non-hospitalized patients. These studies indicate no benefit from the use of HCQ, but they assessed different primary outcomes and presented important biases for outcome evaluation. Objective To evaluate if HCQ may prevent hospitalization due to COVID-19 compared to a matching placebo. Methods The COVID-19 Outpatient Prevention Evaluation (COPE) study is a pragmatic, randomized, double-blind, placebo-controlled clinical trial evaluating the use of HCQ (800 mg on day 1 and 400 mg from day 2 to day 7) or matching placebo for the prevention of hospitalization due to COVID-19 in early non-hospitalized confirmed or suspected cases. Inclusion criteria are adults (≥ 18 years) seeking medical care with mild symptoms of COVID-19, with randomization ≤ 7 days after symptom onset, without indication of hospitalization at study screening, and with at least one risk factor for complication (> 65 years; hypertension; diabetes mellitus; asthma; chronic obstructive pulmonary disease or other chronic lung diseases; smoking; immunosuppression; or obesity). All hypothesis tests will be two-sided. A p-value < 0.05 will be considered statistically significant in all analyses. Clinicaltrials.gov: NCT04466540. Results Clinical outcomes will be centrally adjudicated by an independent clinical event committee blinded to the assigned treatment groups. The primary efficacy endpoint will be assessed following the intention-to-treat principle. Conclusion This study has the potential to reliably answer the scientific question of HCQ use in outpatients with COVID-19. To our knowledge, this is the largest trial evaluating HCQ in non-hospitalized individuals with COVID-19.

Published
2022

46. Delivering Cognitive Stimulation Therapy (CST) Virtually: Developing and Field-Testing a New Framework

Author

Perkins,Luke, Fisher,Emily, Felstead,Cerne, Rooney,Claire, Wong,Gloria HY, Dai,Ruizhi, Vaitheswaran,Sridhar, Natarajan,Nirupama, Mograbi,Daniel, Ferri,Cleusa P, Stott,Joshua, Spector,Aimee, Perkins,Luke, Fisher,Emily, Felstead,Cerne, Rooney,Claire, Wong,Gloria HY, Dai,Ruizhi, Vaitheswaran,Sridhar, Natarajan,Nirupama, Mograbi,Daniel, Ferri,Cleusa P, Stott,Joshua, and Spector,Aimee

Abstract

Luke Perkins,1 Emily Fisher,1 Cerne Felstead,1 Claire Rooney,2 Gloria HY Wong,3 Ruizhi Dai,4 Sridhar Vaitheswaran,5 Nirupama Natarajan,5 Daniel C Mograbi,6,7 Cleusa P Ferri,8,9 Joshua Stott,1 Aimee Spector1 1Research Department of Clinical, Educational and Health Psychology, University College London, London, UK; 2Occupational Therapy Department, Older Persons Services, Our Lady’s Hospice and Care Services, Harold’s Cross, Dublin, Ireland; 3Department of Social Work and Social Administration, University of Hong Kong, Hong Kong, Hong Kong; 4Faculty of Social Sciences, University of Hong Kong, Hong Kong, Hong Kong; 5Dementia Care in Schizophrenia Research Foundation (DEMCARES), Chennai, Tamil Nadu, India; 6Department of Psychology, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil; 7Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; 8Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil; 9Health Technology Assessment Unit, Hospital Alemão Oswaldo Cruz, São Paulo, BrazilCorrespondence: Emily FisherResearch Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London, WC1E 6BT, UK, Tel +44 20 7679 5770, Email emily.fisher@ucl.ac.ukPurpose: This feasibility and pilot study aimed to develop and field-test a 14-session virtual Cognitive Stimulation Therapy (vCST) programme for people living with dementia, developed as a result of services moving online during the COVID-19 pandemic.Methods: The vCST protocol was developed using the existing group CST manual, through stakeholder consultation with people living with dementia, caregivers, CST group facilitators and dementia service managers. This protocol was then field-tested with 10 groups of people living with dementia in the Brazil, China (Hong Kong), India, Ireland and the UK, and feedback on the protocol was gathered from 14 facilitators.Results: Field testing in five countries

Published
2022

47. Risk factors for dementia in Brazil: Differences by region and race.

Author

Suemoto, Claudia K., Mukadam, Naaheed, Brucki, Sonia M.D., Caramelli, Paulo, Nitrini, Ricardo, Laks, Jerson, Livingston, Gill, and Ferri, Cleusa P.

Abstract

Introduction: Twelve risk factors (RFs) account for 40% of dementia cases worldwide. However, most data for population attributable fractions (PAFs) are from high‐income countries (HIC). We estimated how much these RFs account for dementia cases in Brazil, stratifying estimates by race and socioeconomic level. Methods: We calculated the prevalence and communalities of 12 RFs using 9412 Brazilian Longitudinal Study of Aging participants, then stratified according to self‐reported race and country macro‐regions. Results: The overall weighted PAF was 48.2%. Less education had the largest PAF (7.7%), followed by hypertension (7.6%), and hearing loss (6.8%). PAF was 49.0% and 54.0% in the richest and poorest regions, respectively. PAFs were similar among White and Black individuals (47.8% and 47.2%, respectively) but the importance of the main RF varied by race. Discussion: Brazil's potential for dementia prevention is higher than in HIC. Education, hypertension, and hearing loss should be priority targets. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Late-life drinking and smoking in primary care users in Brazil.

Author

Paula, Tassiane C. S., Chagas, Camila, Henrique, Amanda E. G., Vargas, Rafael C., Noto, Ana Regina, and Ferri, Cleusa P.

Subjects
ALCOHOLISM risk factors, RISK-taking behavior, CONFIDENCE intervals, CROSS-sectional method, REGRESSION analysis, PRIMARY health care, RISK assessment, ALCOHOL drinking, RESEARCH funding, DESCRIPTIVE statistics, MENTAL depression, SMOKING, SOCIODEMOGRAPHIC factors, COMPULSIVE behavior, ADULTS, OLD age
Abstract

To estimate the prevalence of at-risk drinking and smoking and associated factors among older adults in primary care in Brazil. A cross-sectional study carried out in seven primary care units with 503 older adults (60+), in a city in the state of Sao Paulo, Brazil. At-risk drinking was defined by AUDIT-C and by consumption of units per week. Poisson regression was used to assess the association between the sociodemographic and health characteristics and smoking and at-risk drinking. The median age of the 503 participants was 69.6 (SD ± 6.7; range:60-93). One third of participants (33.6%) were current drinkers, 16% were at-risk drinkers (AUDIT-C), 4% at-risk drinkers (units per week), and 13% of the sample were regular smokers. The prevalence of at-risk drinking (AUDIT-C) was higher for males (RP: 4.89; 95% CI: 2.52–9.49) and for those with higher levels of education (RP: 1,861.85 95% CI: 1.08–3.14), and lower for those over the age of 70 (RP: 0.50; 95% CI: 0.30-0.84). The prevalence of smoking was higher for those with depressive symptoms (RP: 1.95; 95% CI: 1.03-3.66), and lower for those over age 70 (RP: 0.52; 95% CI: 0.29-0.94). The results point to a set of factors associated with at-risk drinking (being male, younger and having a higher education), and with smoking (being younger and having depressive symptoms). Our findings could help health professionals to identify at-risk drinkers and smokers, as well as support strategies for future interventions by the identification of the groups most vulnerable to these behaviors. [ABSTRACT FROM AUTHOR]

Published
2023
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