1. Clarifying the Confusion between Cytokine and Fc Receptor 'Common Gamma Chain'
- Author
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P. Mark Hogarth, Jeanette H. W. Leusen, Arianne M. Brandsma, and Falk Nimmerjahn
- Subjects
0301 basic medicine ,Letter ,medicine.medical_treatment ,T cell ,Immunology ,Fc receptor ,Receptors, Fc ,Computational biology ,Biology ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Cytokine receptor common gamma chain (γc or CD132) ,Terminology as Topic ,Fc receptor gamma chain (FcRγ) ,medicine ,Animals ,Humans ,Immunology and Allergy ,Receptor ,Sequence (medicine) ,Common gamma chain ,Genetics ,Fc receptors ,Receptors, Antigen, T-Cell, gamma-delta ,cytokines ,030104 developmental biology ,Infectious Diseases ,Cytokine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,biology.protein ,nomenclature ,Signal transduction ,Function (biology) ,Interleukin Receptor Common gamma Subunit ,Signal Transduction - Abstract
The terms for the common cytokine receptor gamma chain (γc or CD132) and the Fc receptor gamma chain (FcRγ) have often been mixed or inconsistently used. This is problematic, because they are clearly distinct molecules in sequence, function, and chromosome location. However, they also share some signaling pathways and can be expressed on the same leukocytes. This makes the term “common gamma chain” potentially misleading, especially to those not in the field. To avoid future confusion, we are proposing the use of a consistent nomenclature to distinguish between the two molecules.
- Published
- 2016
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