28 results on '"Fantinato, Francieli Fontana Sutile Tardetti"'
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2. Serum biomarker profile orchestrating the seroconversion status of patients with autoimmune diseases upon planned primary 17DD Yellow fever vaccination
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da Costa-Rocha, Ismael Artur, Machado, Ketty Lysie Libardi Lira, Campi-Azevedo, Ana Carolina, Teixeira-Carvalho, Andréa, Peruhype-Magalhães, Vanessa, de Lima, Sheila Maria Barbosa, Miranda, Emily Hime, Trindade, Gisela Freitas, Casagrande, Thays Zanon, Miyamoto, Samira Tatiyama, Deotti, Sávio Carvalho, Barbosa, Rafaela Villa Real, Rocha, Priscila Costa Martins, Serrano, Erica Vieira, Dinis, Valquiria Garcia, Gouvêa, Sônia Alves, Gavi, Maria Bernadete Renoldi de Oliveira, da Silva, Lidia Balarini, Duque, Ruben Horst, Gianordoli, Ana Paula Espíndula, Bissoli, Maria de Fatima, Gouvea, Maria da Penha Gomes, Pinto-Neto, Lauro Ferreira da Silva, Burian, Ana Paula Neves, Fantinato, Francieli Fontana Sutile Tardetti, Pileggi, Gecilmara Salviato, da Mota, Licia Maria Henrique, Valim, Valéria, and Martins-Filho, Olindo Assis
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- 2021
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3. Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil
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de Souza, William Marciel, Buss, Lewis Fletcher, Candido, Darlan da Silva, Carrera, Jean-Paul, Li, Sabrina, Zarebski, Alexander E., Pereira, Rafael Henrique Moraes, Prete, Jr, Carlos A., de Souza-Santos, Andreza Aruska, Parag, Kris V., Belotti, Maria Carolina T. D., Vincenti-Gonzalez, Maria F., Messina, Janey, da Silva Sales, Flavia Cristina, Andrade, Pamela dos Santos, Nascimento, Vítor Heloiz, Ghilardi, Fabio, Abade, Leandro, Gutierrez, Bernardo, Kraemer, Moritz U. G., Braga, Carlos K. V., Aguiar, Renato Santana, Alexander, Neal, Mayaud, Philippe, Brady, Oliver J., Marcilio, Izabel, Gouveia, Nelson, Li, Guangdi, Tami, Adriana, de Oliveira, Silvano Barbosa, Porto, Victor Bertollo Gomes, Ganem, Fabiana, de Almeida, Walquiria Aparecida Ferreira, Fantinato, Francieli Fontana Sutile Tardetti, Macário, Eduardo Marques, de Oliveira, Wanderson Kleber, Nogueira, Mauricio L., Pybus, Oliver G., Wu, Chieh-Hsi, Croda, Julio, Sabino, Ester C., and Faria, Nuno Rodrigues
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- 2020
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4. Immune response induced by standard and fractional doses of 17DD yellow fever vaccine.
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Abdala-Torres, Thais, Campi-Azevedo, Ana Carolina, da Silva-Pereira, Rosiane Aparecida, dos Santos, Luara Isabela, Henriques, Priscilla Miranda, Costa-Rocha, Ismael Artur, Otta, Dayane Andriotti, Peruhype-Magalhães, Vanessa, Teixeira-Carvalho, Andréa, Araújo, Márcio Sobreira Silva, Fernandes, Eder Gatti, Sato, Helena Keico, Fantinato, Francieli Fontana Sutile Tardetti, Domingues, Carla Magda Allan Santos, Kallás, Esper Georges, Tomiyama, Helena Tomoko Iwashita, Lemos, Jandira Aparecida Campos, Coelho-dos-Reis, Jordana Grazziela, de Lima, Sheila Maria Barbosa, and Schwarcz, Waleska Dias
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YELLOW fever ,T helper cells ,IMMUNE response ,PLASMA cells ,FC receptors ,T cells ,B cells - Abstract
The re-emergence of yellow fever (YF) urged new mass vaccination campaigns and, in 2017, the World Health Organization approved the use of the fractional dose (FD) of the YF vaccine due to stock shortage. In an observational cross-sectional investigation, we have assessed viremia, antibodies, soluble mediators and effector and memory T and B-cells induced by primary vaccination of volunteers with FD and standard dose (SD). Similar viremia and levels of antibodies and soluble markers were induced early after immunization. However, a faster decrease in the latter was observed after SD. The FD led to a sustained expansion of helper T-cells and an increased expression of activation markers on T-cells early after vaccination. Although with different kinetics, expansion of plasma cells was induced upon SD and FD immunization. Integrative analysis reveals that FD induces a more complex network involving follicular helper T cells and B-cells than SD. Our findings substantiate that FD can replace SD inducing robust correlates of protective immune response against YF. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Factors associated with yellow fever vaccine failure: A systematic literature review
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Fantinato, Francieli Fontana Sutile Tardetti, primary, Wachira, Virginia Kagure, additional, Porto, Victor Bertollo Gomes, additional, Peixoto, Henry Maia, additional, and Duarte, Elisabeth Carmen, additional
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- 2023
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6. Síndrome inflamatória multissistêmica pediátrica: estudo seccional dos casos e fatores associados aos óbitos durante a pandemia de COVID-19 no Brasil, 2020
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Relvas-Brandt, Laís de Almeida, Gava, Caroline, Camelo, Fernanda Sindeaux, Porto, Victor Bertollo Gomes, Alves, Ronaldo Fernandes Santos, Costa, Marcela Santos Correa Da, Carvalho, Sandra Maria Deotti, Carmo, Greice Madeleine Ikeda do, Fantinato, Francieli Fontana Sutile Tardetti, Wada, Marcelo Yoshito, Mendes, Yluska Myrna Meneses Brandão e, Vieira, Martha Gonçalves, Steenhouwer, Roselle Bugarin, Branco, Klebia Magalhães Pereira Castello, Santos, Maria Verônica Câmara dos, Rivera, Ivan Romero, Nicoloso, Luiz Henrique, Safadi, Marco Aurelio Palazzi, and Assis, Dalva Maria de
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Pediatria ,Pediatría ,Morte ,Estudios Transversales ,Síndrome de Respuesta Inflamatoria Sistémica ,Monitoreo Epidemiológico ,Pediatrics ,Systemic Inflammatory Response Syndrome ,Síndrome de Resposta Inflamatória Sistêmica ,Monitoramento Epidemiológico ,Death ,Cross-Sectional Studies ,Muerte ,Epidemiological Monitoring ,Infecções por Coronavírus ,Estudos Transversais ,Infecciones por Coronavirus ,Coronavirus Infections - Abstract
Resumo Objetivo Caracterizar o perfil clínico-epidemiológico da síndrome inflamatória multissistêmica pediátrica temporalmente associada à COVID-19 (SIM-P) e identificar fatores associados aos óbitos de SIM-P no Brasil, 2020. Métodos Estudo seccional, utilizando dados do monitoramento nacional da SIM-P. Empregou-se regressão logística para estimar razões de chances (OR, odds ratios ) brutas e ajustadas. Resultados Os casos (n=652) apresentaram mediana de idade de 5 anos; 57,1% eram do sexo masculino e 52,0% de raça/cor da pele parda; 6,4% evoluíram a óbito. A chance de óbito foi significativamente maior nos que apresentaram saturação de O2
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- 2021
7. Indirect Impact of COVID-19 Vaccination on Weekly Trends in Morbidity and Mortality Indicators in Brazil, 2020 to 2021
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Percio, Jadher, primary, Cabral, Cibelle Mendes, additional, Fantinato, Francieli Fontana Sutile Tardetti, additional, Barrera, Lely Stella Guzmán, additional, and de Araújo, Wildo Navegantes, additional
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- 2021
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8. Coorte retrospectiva de crianças e adolescentes hospitalizados por COVID-19 no Brasil do início da pandemia a 1º de agosto de 2020
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Gomes, Nivreanes Tcherno Nulle, Haslett, Maria Isabella Claudino, Alves, Ana Julia Silva e, Percio, Jadher, Duarte, Magda Machado Saraiva, Malta, Juliane Maria Alves Siqueira, Carvalho, Felipe Cotrim de, Almeida, Walquiria Aparecida Ferreira de, Gava, Caroline, Souza, Libia Roberta de Oliveira, Fantinato, Francieli Fontana Sutile Tardetti, and Santos, Elizabeth David dos
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Hospitalização ,Hospitalization ,Adolescent ,Severe acute respiratory syndrome ,Criança ,Coronavirus infections ,Síndrome respiratória aguda grave ,Child ,Adolescente ,Infecções por coronavírus - Abstract
Resumo: Objetivos: Caracterizar a população do estudo, estimar a taxa de letalidade intra-hospitalar por estado e analisar fatores associados aos óbitos por COVID-19. Métodos: Foi realizado estudo de coorte retrospectiva de crianças e adolescentes hospitalizados com diagnóstico de COVID-19 confirmado por transcrição reversa seguida de reação em cadeia da polimerase (RT-PCR), tendo como desfecho óbito por COVID-19 ou recuperação, entre 1º de março e 1º de agosto de 2020. A fonte de dados foi o Sistema de Informação de Vigilância Epidemiológica da Gripe (SIVEP-Gripe), ao qual são notificados pacientes internados com Síndrome Respiratória Aguda Grave (SRAG). Consideraram-se crianças os pacientes com idade entre 0 e 11 anos completos e adolescentes aqueles com idade entre 12 e 18 anos completos. Realizou-se análise bi e multivariável por meio de Regressão de Poisson com variância robusta, utilizando-se como medida de associação final o Risco Relativo ajustado (RRa). Resultados: Dos 4.930 casos analisados, 2.553 (51,8%) eram do sexo masculino. A raça/cor autodeclarada parda foi a mais frequente, com 2.335 (47,4%). A unidade federativa de Roraima apresentou a maior taxa de letalidade intra-hospitalar, com 68,8% (n = 11/16). A análise multivariada mostrou que pertencer ao grupo etário adolescente (RR = 1,59; IC95% 1,12 - 2,25; p = 0,009), ter sido classificado como SRAG-crítico (RR = 4,56; IC95% 2,77 - 7,51; p < 0,001) e apresentar imunopatia (RR = 2,24; IC95% 1,58 - 3,17; p < 0,001) como comorbidade configuraram-se como fatores associados ao óbito pela COVID-19. Conclusão: Observou-se que ser adolescente, ter classificação de SRAG-crítico e imunopatia como comorbidade foram importantes fatores associados ao óbito. Recomenda-se vigilância ativa e cuidados diferenciados a portadores de doenças crônicas e condições imunológicas especiais. Abstract: Objectives: To characterize the study population, estimating the in-hospital lethality rate by state and analysing associated factors with COVID-19-related deaths. Methods: A retrospective cohort study was carried out of hospitalised children and adolescents diagnosed with COVID-19, confirmed by RT-PCR, whose outcome was death by COVID-19 or recovery, from 2020 March 1 to August 1. The data source was the Influenza Epidemiological Surveillance Information System (SIVEP-Gripe in Brazilian acronym), where patients with Severe Acute Respiratory Syndrome (SARS) are notified. Children were defined as those between the ages of 0 and 11, and adolescents those between 12 and 18. A bi and multivariate analysis were performed using Poisson Regression with robust variance, with adjusted Relative Risk as the final association measure. Results: A total of 4,930 cases were analysed; 2,553 (51.8%) were males, 2,335 (47.4%) were brown-skinned. The Federative Unit of Roraima presented the highest in-hospital case-fatality rate, with 68.8% (11/16). Multivariate analysis showed that belonging to the age group adolescent (RR = 1.59; 95%CI 1.12 - 2.25; p = 0.009), SARS-critical patient (RR = 4.56; 95%CI 2, 77 - 7.51; p < 0.001) and presenting immunological disorders (RR = 2.24; 95%CI 1.58 - 3.17; p < 0.001) as comorbidities were statistically associated factors with death by COVID-19. Conclusion: It was observed that adolescents, SARS-critical patients, and presence of immunological disorders were important factors associated with death. Active surveillance and differentiated care are recommended for patients with chronic diseases and special immunological conditions.
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- 2021
9. CCL3, CCL5, IL-15, IL-1Ra and VEGF compose a reliable algorithm to discriminate classes of adverse events following 17DD-YF primary vaccination according to cause-specific definitions
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Fradico, Jordana Rodrigues Barbosa, primary, Campi-Azevedo, Ana Carolina, additional, Peruhype-Magalhães, Vanessa, additional, Coelho-dos-Reis, Jordana Grazziela Alves, additional, Faria, Elaine Spezialli, additional, Drumond, Betânia Paiva, additional, de Rezende, Izabela Maurício, additional, Almeida, Janaina Fonseca, additional, da Silva, Roberta Barros, additional, Gusmão, Josiane Dias, additional, Arcoverde Medeiros, Eva Lídia, additional, Rodrigues, Regina Coeli Magalhães, additional, Ribeiro, José Geraldo Leite, additional, Pereira, Maira Alves, additional, Silva, Marcos Vinícius Ferreira, additional, Rocha, Marília Lima Cruz, additional, Adelino, Talita Emile Ribeiro, additional, de Melo Iani, Felipe Campos, additional, Pereira, Glauco Carvalho, additional, Fernandes, Eder Gatti, additional, Auxiliadora-Martins, Maria, additional, Valim, Valéria, additional, de Souza Gomes, Matheus, additional, Amaral, Laurence Rodrigues, additional, Romano, Alessandro Pecego Martins, additional, Ramos, Daniel Garkauskas, additional, Carvalho, Sandra Maria Deotti, additional, Fantinato, Francieli Fontana Sutile Tardetti, additional, do Carmo Said, Rodrigo Fabiano, additional, Teixeira-Carvalho, Andréa, additional, and Martins-Filho, Olindo Assis, additional
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- 2021
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10. Description of COVID-19 hospitalized health worker cases in the first nine weeks of the pandemic, Brazil, 2020
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Duarte, Magda Machado Saraiva, Haslett, Maria Isabella Claudino, Freitas, Leonardo José Alves de, Gomes, Nivreanes Tcherno Nulle, Silva, Danielle Cristine Castanha da, Percio, Jadher, Wada, Marcelo Yoshito, Fantinato, Francieli Fontana Sutile Tardetti, Almeida, Walquiria Aparecida Ferreira de, Silva, Daiana Araujo da, Gava, Caroline, França, Giovanny Vinícius Araújo de, Macário, Eduardo Marques, Baêta, Karla Freire, Malta, Juliane Maria Alves Siqueira, and Alves, Ana Julia Silva e
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Epidemiology ,Health Personnel ,Personal de Salud ,Descriptive ,Perfil de Salud ,Perfil de Saúde ,Epidemiologia Descritiva ,Pessoal de Saúde ,Infecciones por Coronavirus ,Coronavirus Infections ,Health Profile ,Infecções por Coronavirus ,Epidemiología Descriptiva - Abstract
Resumo Objetivo: Descrever os casos hospitalizados pela COVID-19 em profissionais de saúde no Brasil. Métodos: Estudo descritivo de tipo série de casos; foram incluídos aqueles com adoecimento entre 21 de fevereiro e 15 de abril de 2020, registrados no Sistema de Informação de Vigilância da Gripe (SIVEP-Gripe). Resultados: Dos 184 casos, 110 (59,8%) eram do sexo feminino, com mediana de idade de 44 anos (mínima-máxima: 23-85); 89 (48,4%) eram profissionais da enfermagem e 50 (27,2%) eram médicos. Ainda, 92 (50,0%) apresentavam comorbidade, predominando cardiopatias (n=37; 40,2%). Dos 112 profissionais com registro de evolução, 85 (75,9%) alcançaram cura e 27 (24,1%) foram a óbito, 18 destes do sexo masculino. Conclusão: O perfil dos profissionais de saúde hospitalizados por COVID-19 é semelhante ao da população quanto à idade e comorbidades; porém, diferente quanto ao sexo. As áreas profissionais mais acometidas foram a enfermagem e a medicina. Resumen Objetivo: Describir los casos hospitalizados por COVID-19 en profesionales de salud, en Brasil. Métodos: Estudio descriptivo del tipo serie de casos; se incluyeron aquellos que enfermaron entre el 21 de febrero y el 15 de abril de 2020, registrados en el Sistema de Información de Vigilancia de la Gripe (SIVEP-Gripe). Resultados: De los 184 (1,76%) casos 110 (59,8%) eran del sexo femenino, con promedio de edad de 44 años (mínima-máxima: 23-85), 89 (48,4%) eran profesionales de enfermería y 50 (27,2%) médicos. Además, 92 (50,0%) presentaron comorbilidad, predominando las cardiopatías (n=37; 40,2%). De los 112 profesionales con un historial de evolución, 85 (75,9%) fueron curados y 27 (24,1%) murieron, 18 de los cuales era de sexo masculino. Conclusión: El perfil de los hospitalizados por COVID-19 es similar al de la población en edad y comorbilidades, aunque diferente con relación a sexo. Las áreas más afectadas fueron la enfermería y la medicina. Abstract Objective: To describe COVID-19 hospitalized health worker cases in Brazil. Methods: This was a descriptive case series study; it included cases that became ill between February 21st and April 15th, 2020 registered on the Influenza Surveillance Information System (SIVEP-Gripe, acronym in Portuguese). Results: Of the 184 cases, 110 (59.8%) were female and median age was 44 years (min-max: 23-85); 89 (48.4%) were nursing professionals and 50 (27.2%) were doctors. Ninety-two (50.0%) presented comorbidity, with heart disease predominating (n=37; 40.2%). Of the 112 professionals with a record of case progression, 85 (75.9%) were cured and 27 (24.1%) died, 18 of whom were male. Conclusion: The profile of COVID-19 hospitalized health workers is similar to that of the general population with regard to age and comorbidities, but different in relation to sex. The most affected areas were nursing and medicine.
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- 2020
11. Falha à vacina febre amarela e fatores associados : uma revisão sistemática da literatura
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Fantinato, Francieli Fontana Sutile Tardetti, Peixoto, Henry Maia, and Duarte, Elisabeth Carmen
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Falha vacinal ,Febre amarela - vacina ,Febre amarela - Abstract
Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Pós-graduação em Medicina Tropical, 2020. Introdução: A febre amarela (FA) é uma doença viral aguda transmitida por vetores dos gêneros Aedes, Haemogogus e Sabethes, e causada por arbovírus do gênero flavivírus. A principal estratégia de prevenção e controle é a vacinação, que tem se demonstrado altamente imunogênica. Desde a sua introdução, apenas 12 casos suspeitos de doença entre vacinados foram documentados no mundo. No Brasil, entre 2016 e 2019, 61 casos confirmados da doença apresentaram histórico de vacinação para FA. Por essa razão, revisar os fatores associados à falha vacinal é relevante para compreender e melhor sistematizar as evidências disponíveis sobre esse tema e esclarecer possíveis fatores associados aos casos confirmados entre vacinados no Brasil. Objetivos: Descrever, avaliar e sistematizar as evidências presentes na literatura acerca da falha à Vacina FA (VFA) e fatores associados. Método: Realizou-se uma revisão sistemática (RS) de estudos epidemiológicos sobre as evidências de falha à VFA e fatores associados. As bases de dados utilizadas foram: PubMed, Cochrane CENTRAL, Embase, LILACS. A qualidade dos estudos observacionais foi avaliada utilizando a Newcastle Ottawa Scale e dos estudos experimentais, a Cochrane Collaboration. Esta revisão seguiu os passos da Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Resultados: Um total de 1466 artigos foi identificado após a busca nas bases de dados e após a aplicação dos critérios de inclusão, 77 artigos foram incluídos na análise qualitativa. Desses artigos, 59,8% eram analíticos, 40,2%, eram descritivos. Na avaliação da qualidade das evidências, os estudos de coorte, em sua maioria, nos itens relacionados ao desfecho, tiveram boa qualidade. Nos ensaios clínicos, a ocultação da alocação e o cegamento foram os itens que receberam as menores avaliações. A RS indicou que a VFA produz imunidade protetora em diferentes grupos etários (exceto crianças menores de dois anos), diferentes tipos de laboratórios produtores, na administração simultânea com uma gama de outras vacinas, em doses fracionadas, na presença de eventos adversos pós- vacinação, em uso de terapias profiláticas e imunossupressoras, em leucemia mieloide crônica, transplantado de células tronco hematopoiéticas e alérgicos ao ovo. Falhou em produzir resposta protetora em gestantes, crianças menores de dois anos, crianças com Kwashiorkor e tempo após a vacinação. Para indivíduos HIV+, os resultados apresentaram-se divergentes. Conclusões: Os resultados dessa RS concluem que a VFA apresenta alta capacidade imunogênica e poucos elementos comprometem essa resposta. Esta RS deu visibilidade aos fatores associados a falha da VFA e seus achados poderão subsidiar as recomendações relativas a política de vacinação, priorizar futuras pesquisas e proteger a credibilidade desta vacina na prevenção de uma doença grave como a FA. Introduction: Yellow fever (YF) is an acute viral disease transmitted by vectors of the genera Aedes, Haemogogus and Sabethes, and caused by an RNA virus that belongs to the genus Flavivirus. The main prevention and control strategy is vaccination, which has been shown to be highly immunogenic. Since its introduction, among vaccinees only 12 suspected cases of the disease have been documented in the world. In Brazil, between the years of 2016 and 2019, a total of 61 confirmed cases of the disease had a history of previous vaccination. For this reason, to review the associated factors with vaccine failure is relevant to understand and better systematize the available evidence on this topic and to clarify possible factors associated with confirmed cases among vaccinees in Brazil. Objectives: To describe, evaluate and systematize the evidence in the literature about yellow fever vaccine (YFV) and associated factors. Method: A systematic review (SR) of epidemiological studies was carried out on the evidence of YFV failure and associated factors. The databases used were: PubMed, Cochrane CENTRAL, Embase, LILACS. The quality of observational studies was assessed using the Newcastle Ottawa Scale and experimental studies, the Cochrane Collaboration. This review followed in the footsteps of Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. Results: A total of 1466 articles were identified after searching the databases and after applying the inclusion criteria and 77 articles were included in the qualitative analysis. Of these articles, 59.8% were analytical, 40.2% were descriptive. Most of the cohort studies related to the outcomes were of good quality and in clinical trials, concealment of allocation and blinding were the items that received the lowest evaluations. The SR indicated that the YFV produces protective immunity in different age groups (except children under two years old), different types of producers, in simultaneous administration with other vaccines, in fractional doses, in the presence of adverse events following-immunization, using prophylactic and immunosuppressive therapies, in chronic myeloid leukemia, hematopoietic stem cells transplants and eggs allergy. It failed to produce a protective response in pregnant women, children under two years of age, children with Kwashiorkor and time after vaccination. For HIV + individuals, the results were divergent. Conclusions: The results of this SR conclude that YFV has a high immunogenic capacity and few elements compromise its response and gave visibility to the factors associated with the failure of the vaccine and its findings may support the recommendations regarding the vaccination policy, prioritizing future researches and enhancing the vaccine credibility in the prevention of a serious disease such as YF.
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- 2020
12. Epidemiological and clinical characteristics of the early phase of the COVID-19 epidemic in Brazil
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Souza, William Marciel de, Buss, Lewis Fletcher, da Silva Candido, Darlan, Carrera, Jean Paul, Li, Sabrina, Zarebski, Alexander, Vincenti-Gonzalez, Maria, Messina, Janey, Sales, Flavia Cristina da Silva, Andrade, Pamela dos Santos, Prete Jr., Carlos A, Nascimento, Vitor Heloiz, Ghilardi, Fabio, Pereira, Rafael Henrique Moraes, Santos, Andreza Aruska de Souza, Abade, Leandro, Gutierrez, Bernardo, Kraemer, Moritz U. G., Aguiar, Renato Santana, Alexander, Neal, Mayaud, Philippe, Brady, Oliver J, Souza, Izabel Oliva Marcilio de, Gouveia, Nelson, Li, Guangdi, Tami, Adriana, Oliveira, Silvano Barbosa, Porto, Victor Bertollo Gomes, Ganem, Fabiana, Almeida, Walquiria Ferreira, Fantinato, Francieli Fontana Sutile Tardetti, Macario, Eduardo Marques, Oliveira, Wanderson Kleber, Pybus, Oliver, Wu, Chieh-Hsi, Croda, Julio, Sabino, Ester Cerdeira, and Faria, Nuno R.
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Transmission (medicine) ,virus diseases ,Disease ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Logistic regression ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,medicine ,030212 general & internal medicine ,Rhinovirus ,Early phase ,business ,Socioeconomic status ,Demography - Abstract
SummaryBackgroundThe first case of COVID-19 was detected in Brazil on February 25, 2020. We report the epidemiological, demographic, and clinical findings for confirmed COVID-19 cases during the first month of the epidemic in Brazil.MethodsIndividual-level and aggregated COVID-19 data were analysed to investigate demographic profiles, socioeconomic drivers and age-sex structure of COVID-19 tested cases. Basic reproduction numbers (R0) were investigated for São Paulo and Rio de Janeiro. Multivariate logistic regression analyses were used to identify symptoms associated with confirmed cases and risk factors associated with hospitalization. Laboratory diagnosis for eight respiratory viruses were obtained for 2,429 cases.FindingsBy March 25, 1,468 confirmed cases were notified in Brazil, of whom 10% (147 of 1,468) were hospitalised. Of the cases acquired locally (77·8%), two thirds (66·9% of 5,746) were confirmed in private laboratories. Overall, positive association between higher per capita income and COVID-19 diagnosis was identified. The median age of detected cases was 39 years (IQR 30-53). The median R0 was 2·9 for São Paulo and Rio de Janeiro. Cardiovascular disease/hypertension were associated with hospitalization. Co-circulation of six respiratory viruses, including influenza A and B and human rhinovirus was detected in low levels.InterpretationSocioeconomic disparity determines access to SARS-CoV-2 testing in Brazil. The lower median age of infection and hospitalization compared to other countries is expected due to a younger population structure. Enhanced surveillance of respiratory pathogens across socioeconomic statuses is essential to better understand and halt SARS-CoV-2 transmission.FundingSão Paulo Research Foundation, Medical Research Council, Wellcome Trust and Royal Society.
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- 2020
13. Descrição dos casos hospitalizados pela COVID-19 em profissionais de saúde nas primeiras nove semanas da pandemia, Brasil, 2020
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Duarte,Magda Machado Saraiva, Haslett,Maria Isabella Claudino, Freitas,Leonardo José Alves de, Gomes,Nivreanes Tcherno Nulle, Silva,Danielle Cristine Castanha da, Percio,Jadher, Wada,Marcelo Yoshito, Fantinato,Francieli Fontana Sutile Tardetti, Almeida,Walquiria Aparecida Ferreira de, Silva,Daiana Araujo da, Gava,Caroline, França,Giovanny Vinícius Araújo de, Macário,Eduardo Marques, Baêta,Karla Freire, Malta,Juliane Maria Alves Siqueira, and Alves,Ana Julia Silva e
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Perfil de Saúde ,Epidemiologia Descritiva ,Pessoal de Saúde ,Infecções por Coronavirus - Abstract
Resumo Objetivo: Descrever os casos hospitalizados pela COVID-19 em profissionais de saúde no Brasil. Métodos: Estudo descritivo de tipo série de casos; foram incluídos aqueles com adoecimento entre 21 de fevereiro e 15 de abril de 2020, registrados no Sistema de Informação de Vigilância da Gripe (SIVEP-Gripe). Resultados: Dos 184 casos, 110 (59,8%) eram do sexo feminino, com mediana de idade de 44 anos (mínima-máxima: 23-85); 89 (48,4%) eram profissionais da enfermagem e 50 (27,2%) eram médicos. Ainda, 92 (50,0%) apresentavam comorbidade, predominando cardiopatias (n=37; 40,2%). Dos 112 profissionais com registro de evolução, 85 (75,9%) alcançaram cura e 27 (24,1%) foram a óbito, 18 destes do sexo masculino. Conclusão: O perfil dos profissionais de saúde hospitalizados por COVID-19 é semelhante ao da população quanto à idade e comorbidades; porém, diferente quanto ao sexo. As áreas profissionais mais acometidas foram a enfermagem e a medicina.
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- 2020
14. Síndrome inflamatória multissistêmica pediátrica: estudo seccional dos casos e fatores associados aos óbitos durante a pandemia de COVID-19 no Brasil, 2020
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Relvas-Brandt, Laís de Almeida, primary, Gava, Caroline, additional, Camelo, Fernanda Sindeaux, additional, Porto, Victor Bertollo Gomes, additional, Alves, Ronaldo Fernandes Santos, additional, Costa, Marcela Santos Correa Da, additional, Carvalho, Sandra Maria Deotti, additional, Carmo, Greice Madeleine Ikeda do, additional, Fantinato, Francieli Fontana Sutile Tardetti, additional, Wada, Marcelo Yoshito, additional, Mendes, Yluska Myrna Meneses Brandão e, additional, Vieira, Martha Gonçalves, additional, Steenhouwer, Roselle Bugarin, additional, Branco, Klebia Magalhães Pereira Castello, additional, Santos, Maria Verônica Câmara dos, additional, Rivera, Ivan Romero, additional, Nicoloso, Luiz Henrique, additional, Safadi, Marco Aurelio Palazzi, additional, and Assis, Dalva Maria de, additional
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- 2021
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15. Coorte retrospectiva de crianças e adolescentes hospitalizados por COVID-19 no Brasil do início da pandemia a 1º de agosto de 2020
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Gomes, Nivreanes Tcherno Nulle, primary, Haslett, Maria Isabella Claudino, additional, Alves, Ana Julia Silva e, additional, Percio, Jadher, additional, Duarte, Magda Machado Saraiva, additional, Malta, Juliane Maria Alves Siqueira, additional, Carvalho, Felipe Cotrim de, additional, Almeida, Walquiria Aparecida Ferreira de, additional, Gava, Caroline, additional, Souza, Libia Roberta de Oliveira, additional, Fantinato, Francieli Fontana Sutile Tardetti, additional, and Santos, Elizabeth David dos, additional
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- 2021
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16. Descrição dos casos hospitalizados pela COVID-19 em profissionais de saúde nas primeiras nove semanas da pandemia, Brasil, 2020
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Duarte, Magda Machado Saraiva, primary, Haslett, Maria Isabella Claudino, additional, Freitas, Leonardo José Alves de, additional, Gomes, Nivreanes Tcherno Nulle, additional, Silva, Danielle Cristine Castanha da, additional, Percio, Jadher, additional, Wada, Marcelo Yoshito, additional, Fantinato, Francieli Fontana Sutile Tardetti, additional, Almeida, Walquiria Aparecida Ferreira de, additional, Silva, Daiana Araujo da, additional, Gava, Caroline, additional, França, Giovanny Vinícius Araújo de, additional, Macário, Eduardo Marques, additional, Baêta, Karla Freire, additional, Malta, Juliane Maria Alves Siqueira, additional, and Alves, Ana Julia Silva e, additional
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- 2020
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17. Planned Yellow Fever Primary Vaccination Is Safe and Immunogenic in Patients With Autoimmune Diseases: A Prospective Non-interventional Study
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Valim, Valéria, primary, Machado, Ketty Lysie Libardi Lira, additional, Miyamoto, Samira Tatiyama, additional, Pinto, Arthur Dalmaso, additional, Rocha, Priscila Costa Martins, additional, Serrano, Erica Vieira, additional, Dinis, Valquiria Garcia, additional, Gouvêa, Sônia Alves, additional, Dias, João Gabriel Fragoso, additional, Campi-Azevedo, Ana Carolina, additional, Teixeira-Carvalho, Andréa, additional, Peruhype-Magalhães, Vanessa, additional, Costa-Rocha, Ismael Artur da, additional, Lima, Sheila Maria Barbosa de, additional, Miranda, Emily Hime, additional, Trindade, Gisela Freitas, additional, Maia, Maria de Lourdes de Sousa, additional, Gavi, Maria Bernadete Renoldi de Oliveira, additional, Silva, Lidia Balarini da, additional, Duque, Ruben Horst, additional, Gianordoli, Ana Paula Espíndula, additional, Casagrande, Thays Zanon, additional, Oliveira, Karine Gadioli, additional, Moura, Bruna Costa da Mata, additional, Nicole-Batista, Fernanda, additional, Rodrigues, Luiza Correa, additional, Clemente, Thalles Brandão, additional, Magalhães, Enan Sales, additional, Bissoli, Maria de Fatima, additional, Gouvea, Maria da Penha Gomes, additional, Pinto-Neto, Lauro Ferreira da Silva, additional, Costa, Carolina Zorzanelli, additional, Giovelli, Raquel Altoé, additional, Brandão, Leticia Resende, additional, Polito, Elizandra Tomazela Laurenti, additional, Koehlert, Ingrid de Oliveira, additional, Borjaille, Brunela Passos, additional, Pereira, Daniela Bergamim, additional, Dias, Laiza Hombre, additional, Merlo, Daniela Linhares, additional, Genelhu, Luiz Fellipe Favoreto, additional, Pretti, Flavia Zon, additional, Giacomin, Maryella dos Santos, additional, Burian, Ana Paula Neves, additional, Fantinato, Francieli Fontana Sutile Tardetti, additional, Pileggi, Gecilmara Salviato, additional, Mota, Lícia Maria Henrique da, additional, and Martins-Filho, Olindo Assis, additional
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- 2020
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18. Monitoring social distancing and SARS-CoV-2 transmission in Brazil using cell phone mobility data
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de Oliveira, Silvano Barbosa, primary, Pôrto, Victor Bertollo Gomes, additional, Ganem, Fabiana, additional, Mendes, Fabio Macedo, additional, Almiron, Maria, additional, de Oliveira, Wanderson Kleber, additional, Fantinato, Francieli Fontana Sutile Tardetti, additional, de Almeida, Walquiria Aparecida Ferreira, additional, de Macedo Borges, Abel Pereira, additional, Pinheiro, Hector Natan Batista, additional, Oliveira, Raíza dos Santos, additional, Andrews, Jason R., additional, Faria, Nuno R, additional, Lopes, Marcelo Barreto, additional, de Araújo, Wildo Navegantes, additional, Diaz-Quijano, Fredi A., additional, Nakaya, Helder I., additional, and Croda, Julio, additional
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- 2020
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19. Anafilaxia relacionada a la vacuna sarampión, paperas y rubeola, Santa Catarina, Brasil, 2014 y 2015
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Fantinato, Francieli Fontana Sutile Tardetti, Vargas, Alexander, Carvalho, Sandra Maria Deotti, Domingues, Carla Magda Allan Santos, Barreto, Gisele, Fialho, Arieli Schiessl, Silva, Roselita Heinen da, Saad, Eduardo, and Agredo, Ivonne Natalia Solarte
- Subjects
Vacinação ,Vacina Contra Sarampo-Caxumba-Rubéola ,Vacuna Contra el Sarampión-Parotiditis-Rubéola ,Niño ,Vaccination ,Vacunación ,Criança ,Child ,Anaphylaxis ,Anafilaxia ,Measles-Mumps-Rubella Vaccine - Abstract
Resumo: Os objetivos consistiram em descrever os casos e verificar a frequência de anafilaxia relacionada à vacina sarampo, caxumba e rubéola (SCR) do produtor A, bem como avaliar os possíveis fatores de risco associados. Estudo de caso-controle (1:4), em Santa Catarina, Brasil, de 14 de julho de 2014 a 12 de janeiro de 2015, em crianças de um a menores de cinco anos, vacinadas com SCR e notificadas com anafilaxia, sendo os controles sem anafilaxia. Utilizou-se, como medida de associação, odds ratio (OR) com intervalo de 95% de confiança (IC95%) e os testes qui-quadrado e exato de Fisher. Calcularam-se taxas de anafilaxia por doses distribuídas/aplicadas. Entrevistaram-se 15 casos e 60 controles, em 12 municípios. As taxas de anafilaxia foram 2,46 e 5,05 por doses distribuídas e aplicadas, respectivamente. Dentre os casos de anafilaxia, oito (53,4%) eram do sexo masculino, e dentre os controles, 36 (60%), com p = 0,64. Na análise bivariada referente à anafilaxia e alergia à proteína do leite de vaca (APLV), verificou-se OR = 51,62, com p = 0,00002 e IC95%: 5,59-476,11. As variáveis alergia alimentar familiar, aleitamento materno, evento adverso pós-vacinação (EAPV) anterior e vacinação simultânea não foram estatisticamente significativas (p = 0,48; p = 1,00; p = 0,49; p = 0,61). Taxas de anafilaxia por doses distribuídas/aplicadas ficaram acima de 1/100 mil doses aplicadas (taxa esperada). Anafilaxia e APLV apresentaram associação estatisticamente significativa. Não foram encontradas associações estatísticas referentes à vacinação simultânea, aleitamento materno, alergia alimentar familiar e EAPV anterior. Recomendou-se ao produtor informar na bula todos os componentes do produto e que crianças com história pregressa de APLV não sejam vacinadas com essa vacina. Abstract: The study aimed to describe cases and verify the frequency of anaphylaxis related to measles, mumps, and rubella (MMR) vaccine produced by manufacturer A and to assess associated risk factors. This was a case-control study (1:4) in Santa Catarina State, Brazil, from July 14, 2014, to January 12, 2015, in children from one year to less than five years of age, vaccinated with MMR and reported with anaphylaxis, while the controls were without anaphylaxis. The measure of association was odds ratio (OR) with 95% confidence interval (95%CI), using the chi-square and Fisher’s exact tests. Anaphylaxis rates were calculated per doses distributed/administered. Fifteen cases and 60 controls were interviewed in 12 municipalities (counties). Anaphylaxis rates were 2.46 and 5.05 cases per 100,000 doses distributed and administered, respectively. Among the cases of anaphylaxis, eight (53.4%) were males, and among the controls, 36 (60%), with p = 0.64. The bivariate analysis of anaphylaxis and cow’s milk protein allergy (CMPA) showed OR = 51.62, with p = 0.00002 and 95%CI: 5.59-476.11. The variables family food allergy, breastfeeding, previous post-vaccine adverse event (PVAE), and simultaneous vaccination were not statistically significant (p = 0.48; p = 1.00; p = 0.49; p = 0.61). Anaphylaxis rates per doses distributed/administered exceeded 1/100,000 doses administered (expected rate). Anaphylaxis and CMPA showed a statistically significant association. No statistically significant associations were found with simultaneous vaccination, breastfeeding, family food allergy, or history of PVAE. Recommendations: the manufacturer should specify the product’s components in the package insert, and children with a history of CMPA should not be vaccinated with this vaccine. Resumen: Los objetivos consistieron en describir los casos y verificar la frecuencia de anafilaxia, relacionada con la vacuna del sarampión, paperas y rubeola (SCR) del productor A, así como evaluar los posibles factores de riesgo asociados. Estudio de caso-control (1:4), en Santa Catarina, Brasil, de 14 de julio de 2014 a 12 de enero de 2015, en niños de uno a menores de cinco años, vacunadas con SCR y notificadas con anafilaxia, siendo los controles sin anafilaxia. Se utilizó, como medida de asociación, odds ratio (OR) con un intervalo de 95% de confianza (IC95%) y los testes chi-cuadrado y exacto de Fisher. Se calcularon las tasas de anafilaxia por dosis distribuidas/aplicadas. Se entrevistaron 15 casos y 60 controles, en 12 municipios. Las tasas de anafilaxia fueron 2,46 y 5,05 por dosis distribuidas y aplicadas, respectivamente. Entre los casos de anafilaxia, ocho (53,4%) eran del sexo masculino, y entre los controles, 36 (60%), con p = 0,64. En el análisis bivariado referente a la anafilaxia y alergia a la proteína de leche de vaca (APLV), se verificó OR = 51,62, con p = 0,00002 e IC95%: 5,59-476,11. Las variables alergia alimentaria familiar, lactancia materna , evento adverso pos-vacunación (EAPV) anterior y vacunación simultánea no fueron estadísticamente significativas (p = 0,48; p = 1,00; p = 0,49; p = 0,61). Tasas de anafilaxia por dosis distribuidas/aplicadas se situaron encima de 1/100.000 dosis aplicadas (tasa esperada). Anafilaxia y APLV presentaron una asociación estadísticamente significativa. No fueron encontradas asociaciones estadísticas referentes a la vacunación simultánea, lactancia materna, alergia alimentaria familiar y EAPV anterior. Se recomendó al productor informar en el prospecto sobre todos los componentes del producto, y que los niños con historial anterior de APLV no sean vacunados con esa vacuna.
- Published
- 2018
20. Anafilaxia relacionada à vacina sarampo, caxumba e rubéola, Santa Catarina, Brasil, 2014 e 2015
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Fantinato, Francieli Fontana Sutile Tardetti, primary, Vargas, Alexander, additional, Carvalho, Sandra Maria Deotti, additional, Domingues, Carla Magda Allan Santos, additional, Barreto, Gisele, additional, Fialho, Arieli Schiessl, additional, Silva, Roselita Heinen da, additional, Saad, Eduardo, additional, and Agredo, Ivonne Natalia Solarte, additional
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- 2018
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21. Association and birth prevalence of microcephaly attributable to Zika virus infection among infants in Paraíba, Brazil, in 2015–16: a case-control study
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Krow-Lucal, Elisabeth R, primary, de Andrade, Marcia Regina, additional, Cananéa, Juliana Nunes Abath, additional, Moore, Cynthia A, additional, Leite, Priscila Leal, additional, Biggerstaff, Brad J, additional, Cabral, Cibelle Mendes, additional, Itoh, Megumi, additional, Percio, Jadher, additional, Wada, Marcelo Y, additional, Powers, Ann M, additional, Barbosa, Aristides, additional, Abath, Roberta Batista, additional, Staples, J Erin, additional, Coelho, Giovanini Evelim, additional, Araújo, Emerson, additional, Medeiros, Eva Lídia Arcoverde, additional, Brant, Jonas, additional, Cerroni, Matheus, additional, de Barros Moreira Beltrão, Henrique, additional, Fantinato, Francieli Fontana Sutile Tardetti, additional, Lise, Michael Laurence Zini, additional, Ohara, Patrícia Miyuki, additional, Resende, Elionardo, additional, Saad, Eduardo, additional, de St. Maurice, Annabelle, additional, Dieke, Ada, additional, Harrist, Alexia, additional, Kwit, Natalie, additional, Marlow, Mariel, additional, Soke, Gnakub, additional, de Arruda Pessoa, Roseanne, additional, da Silva, Renata Candido, additional, Diniz, Rogéria Chelly, additional, de Araújo Ariette, Micheline César, additional, Lira, Clarice França, additional, Matos, Sandra, additional, Wanderley, Taciana Mendonça Maia, additional, Silva, Vanessa Oliveira Costa, additional, da Silva, Hélio Soares, additional, Carmo, Eduardo Hage, additional, Carvalho, Myrian, additional, Lentini, Nena, additional, Miranda, Raquel, additional, Boland, Erin, additional, Burns, Paul, additional, Fischer, Marc, additional, Ledermann, Jeremy, additional, Coronado, Fatima, additional, Dicent-Taillepierre, Julio, additional, Flannery, Brendan, additional, Macedo de Oliveira, Alexandre, additional, and Arena, José Fernando, additional
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- 2018
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22. Descrição dos primeiros casos de febre pelo vírus Zika investigados em municípios da região Nordeste do Brasil, 2015
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Fantinato, Francieli Fontana Sutile Tardetti, primary, Araújo, Emerson Luiz Lima, additional, Ribeiro, Igor Gonçalves, additional, Andrade, Marcia Regina de, additional, Dantas, Anna Livia de Medeiros, additional, Rios, Jakeline Maria Trinta, additional, Silva, Odila Márcia Vinhas da, additional, Silva, Maria do Socorro da, additional, Nóbrega, Renata Valeria, additional, Batista, Daniel de Araújo, additional, Leite, Priscila Leal e, additional, Saad, Eduardo, additional, Percio, Jadher, additional, Resende, Elionardo Andrade, additional, Souza, Priscila Bochi de, additional, Wada, Marcelo Yoshito, additional, and Fantinato, Francieli Fontana Sutile Tardetti, additional
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- 2016
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23. Comprehensive landscape of neutralizing antibody and cell-mediated response elicited by the 1/5 fractional dose of 17DD-YF primary vaccination in adults.
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Reis LR, Costa-Rocha IA, Abdala-Torres T, Campi-Azevedo AC, Peruhype-Magalhães V, Araújo MSS, Spezialli E, do Valle Antonelli LR, da Silva-Pereira RA, Almeida GG, Fernandes EG, Fantinato FFST, Domingues CMAS, Lemos MCF, Chieppe A, Lemos JAC, Coelho-Dos-Reis JG, de Lima SMB, de Souza Azevedo A, Schwarcz WD, Camacho LAB, de Lourdes de Sousa Maia M, de Noronha TG, Duault C, Rosenberg-Hasson Y, Teixeira-Carvalho A, Maecker HT, and Martins-Filho OA
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- Humans, Adult, Antibodies, Neutralizing, Interleukin-10, Antibodies, Viral, Tumor Necrosis Factor-alpha, CD8-Positive T-Lymphocytes, Vaccination, Yellow Fever Vaccine, Yellow Fever
- Abstract
The present study aimed at evaluating the YF-specific neutralizing antibody profile besides a multiparametric analysis of phenotypic/functional features of cell-mediated response elicited by the 1/5 fractional dose of 17DD-YF vaccine, administered as a single subcutaneous injection. The immunological parameters of each volunteer was monitored at two time points, referred as: before (Day 0) [Non-Vaccinated, NV
(D0) ] and after vaccination (Day 30-45) [Primary Vaccinees, PV(D30-45) ]. Data demonstrated high levels of neutralizing antibodies for PV(D30-45) leading to a seropositivity rate of 93%. A broad increase of systemic soluble mediators with a mixed profile was also observed for PV(D30-45) , with IFN-γ and TNF-α presenting the highest baseline fold changes. Integrative network mapping of soluble mediators showed increased correlation numbers in PV(D30-45) as compared to NV(D0) (532vs398). Moreover, PV(D30-45) exhibited increased levels of Terminal Effector (CD45RA+ CCR7- ) CD4+ and CD8+ T-cells and Non-Classical memory B-cells (IgD+ CD27+ ). Dimensionality reduction of Mass Cytometry data further support these findings. A polyfunctional cytokine profile (TNF-α/IFN-γ/IL-10/IL-17/IL-2) of T and B-cells was observed upon in vitro antigen recall. Mapping and kinetics timeline of soluble mediator signatures for PV(D30-45) further confirmed the polyfunctional profile upon long-term in vitro culture, mediated by increased levels of IFN-γ and TNF-α along with decreased production of IL-10. These findings suggest novel insights of correlates of protection elicited by the 1/5 fractional dose of 17DD-YF vaccine., (© 2024. The Author(s).)- Published
- 2024
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24. Multisystem inflammatory syndrome in children: a cross-sectional study of cases and factors associated with deaths during the COVID-19 pandemic in Brazil, 2020.
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Relvas-Brandt LA, Gava C, Camelo FS, Porto VBG, Alves RFS, Costa MSCD, Carvalho SMD, Carmo GMID, Fantinato FFST, Wada MY, Mendes YMMBE, Vieira MG, Steenhouwer RB, Branco KMPC, Santos MVCD, Rivera IR, Nicoloso LH, Safadi MAP, and Assis DM
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- Brazil epidemiology, Child, Child, Preschool, Cross-Sectional Studies, Humans, Male, Pandemics, SARS-CoV-2, Systemic Inflammatory Response Syndrome, COVID-19 complications
- Abstract
Objective: To characterize the clinical-epidemiological profile of multisystem inflammatory syndrome in children temporally associated with COVID-19 (MIS-C), and to identify factors associated with MIS-C deaths in Brazil, 2020., Methods: This was a cross-sectional study, using national MIS-C monitoring data. Logistical regression was performed to estimate crude and adjusted odds ratios (OR)., Results: Median case (n=652) age was 5 years, 57.1% were male, 52.0% were of brown race/skin color and 6.4% died. Likelihood of death was greater among those who presented O2 saturation <95% (ORa=4.35 - 95%CI 1.69;11.20) and altered urea results (ORa=5.18 - 95%CI 1.91;14.04); likelihood of death was lower when red skin blotches were not present (ORa=0.23 - 95%CI 0.09;0.62), when anticoagulants were used (ORa=0.32 - 95%CI 0.12;0.89) and when immunoglobulins were used (ORa=0.38 - 95%CI 0.15;1.01)., Conclusion: Fatality ratios were higher among cases that presented O2 saturation <95% and altered urea results. Fatality ratios were lower among those with red skin blotches, and those who used immunoglobulins and anticoagulants.
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- 2021
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25. Retrospective cohort of children and adolescents hospitalized by COVID-19 in Brazil from the beginning of the pandemic to August 1st, 2020.
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Gomes NTN, Haslett MIC, Alves AJSE, Percio J, Duarte MMS, Malta JMAS, Carvalho FC, Almeida WAF, Gava C, Souza LRO, Fantinato FFST, and Santos EDD
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- Adolescent, Brazil epidemiology, Child, Child, Preschool, Cohort Studies, Comorbidity, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, SARS-CoV-2, COVID-19, Pandemics
- Abstract
Objectives: To characterize the study population, estimating the in-hospital lethality rate by state and analysing associated factors with COVID-19-related deaths., Methods: A retrospective cohort study was carried out of hospitalised children and adolescents diagnosed with COVID-19, confirmed by RT-PCR, whose outcome was death by COVID-19 or recovery, from 2020 March 1 to August 1. The data source was the Influenza Epidemiological Surveillance Information System (SIVEP-Gripe in Brazilian acronym), where patients with Severe Acute Respiratory Syndrome (SARS) are notified. Children were defined as those between the ages of 0 and 11, and adolescents those between 12 and 18. A bi and multivariate analysis were performed using Poisson Regression with robust variance, with adjusted Relative Risk as the final association measure., Results: A total of 4,930 cases were analysed; 2,553 (51.8%) were males, 2,335 (47.4%) were brown-skinned. The Federative Unit of Roraima presented the highest in-hospital case-fatality rate, with 68.8% (11/16). Multivariate analysis showed that belonging to the age group adolescent (RR = 1.59; 95%CI 1.12 - 2.25; p = 0.009), SARS-critical patient (RR = 4.56; 95%CI 2, 77 - 7.51; p < 0.001) and presenting immunological disorders (RR = 2.24; 95%CI 1.58 - 3.17; p < 0.001) as comorbidities were statistically associated factors with death by COVID-19., Conclusion: It was observed that adolescents, SARS-critical patients, and presence of immunological disorders were important factors associated with death. Active surveillance and differentiated care are recommended for patients with chronic diseases and special immunological conditions.
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- 2021
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26. Description of COVID-19 hospitalized health worker cases in the first nine weeks of the pandemic, Brazil, 2020.
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Duarte MMS, Haslett MIC, Freitas LJA, Gomes NTN, Silva DCCD, Percio J, Wada MY, Fantinato FFST, Almeida WAF, Silva DAD, Gava C, França GVA, Macário EM, Baêta KF, Malta JMAS, and Alves AJSE
- Subjects
- Adult, Age Distribution, Aged, Aged, 80 and over, Brazil epidemiology, COVID-19, Comorbidity, Coronavirus Infections mortality, Disease Progression, Female, Heart Diseases epidemiology, Humans, Male, Medical Staff statistics & numerical data, Middle Aged, Nursing Staff statistics & numerical data, Pandemics, Pneumonia, Viral mortality, SARS-CoV-2, Sex Distribution, Time Factors, Young Adult, Betacoronavirus, Coronavirus Infections epidemiology, Health Personnel statistics & numerical data, Hospitalization statistics & numerical data, Pneumonia, Viral epidemiology
- Abstract
Objective: To describe COVID-19 hospitalized health worker cases in Brazil., Methods: This was a descriptive case series study; it included cases that became ill between February 21st and April 15th, 2020 registered on the Influenza Surveillance Information System (SIVEP-Gripe, acronym in Portuguese)., Results: Of the 184 cases, 110 (59.8%) were female and median age was 44 years (min-max: 23-85); 89 (48.4%) were nursing professionals and 50 (27.2%) were doctors. Ninety-two (50.0%) presented comorbidity, with heart disease predominating (n=37; 40.2%). Of the 112 professionals with a record of case progression, 85 (75.9%) were cured and 27 (24.1%) died, 18 of whom were male., Conclusion: The profile of COVID-19 hospitalized health workers is similar to that of the general population with regard to age and comorbidities, but different in relation to sex. The most affected areas were nursing and medicine.
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- 2020
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27. [Anaphylaxis related to measles, mumps, and rubella vaccine in Santa Catarina State, Brazil, 2014 and 2015].
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Fantinato FFST, Vargas A, Carvalho SMD, Domingues CMAS, Barreto G, Fialho AS, Silva RHD, Saad E, and Agredo INS
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- Anaphylaxis physiopathology, Brazil, Case-Control Studies, Child, Preschool, Female, Humans, Infant, Interviews as Topic, Male, Measles prevention & control, Mumps prevention & control, Residence Characteristics, Risk Factors, Rubella prevention & control, Vaccination adverse effects, Vaccination statistics & numerical data, Anaphylaxis chemically induced, Measles-Mumps-Rubella Vaccine adverse effects
- Abstract
The study aimed to describe cases and verify the frequency of anaphylaxis related to measles, mumps, and rubella (MMR) vaccine produced by manufacturer A and to assess associated risk factors. This was a case-control study (1:4) in Santa Catarina State, Brazil, from July 14, 2014, to January 12, 2015, in children from one year to less than five years of age, vaccinated with MMR and reported with anaphylaxis, while the controls were without anaphylaxis. The measure of association was odds ratio (OR) with 95% confidence interval (95%CI), using the chi-square and Fisher's exact tests. Anaphylaxis rates were calculated per doses distributed/administered. Fifteen cases and 60 controls were interviewed in 12 municipalities (counties). Anaphylaxis rates were 2.46 and 5.05 cases per 100,000 doses distributed and administered, respectively. Among the cases of anaphylaxis, eight (53.4%) were males, and among the controls, 36 (60%), with p = 0.64. The bivariate analysis of anaphylaxis and cow's milk protein allergy (CMPA) showed OR = 51.62, with p = 0.00002 and 95%CI: 5.59-476.11. The variables family food allergy, breastfeeding, previous post-vaccine adverse event (PVAE), and simultaneous vaccination were not statistically significant (p = 0.48; p = 1.00; p = 0.49; p = 0.61). Anaphylaxis rates per doses distributed/administered exceeded 1/100,000 doses administered (expected rate). Anaphylaxis and CMPA showed a statistically significant association. No statistically significant associations were found with simultaneous vaccination, breastfeeding, family food allergy, or history of PVAE., Recommendations: the manufacturer should specify the product's components in the package insert, and children with a history of CMPA should not be vaccinated with this vaccine.
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- 2018
- Full Text
- View/download PDF
28. Description of the first cases of Zika virus fever investigated in municipalities of the Brazilian Northeastern Region, 2015.
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Fantinato FF, Araújo EL, Ribeiro IG, Andrade MR, Dantas AL, Rios JM, Silva OM, Silva MD, Nóbrega RV, Batista DA, Leite PL, Saad E, Percio J, Resende EA, Souza PB, and Wada MY
- Subjects
- Adolescent, Adult, Brazil epidemiology, Child, Child, Preschool, Cities epidemiology, Dengue, Exanthema diagnosis, Exanthema etiology, Humans, Infant, Infant, Newborn, Middle Aged, Young Adult, Zika Virus Infection complications, Zika Virus Infection epidemiology, Symptom Assessment, Zika Virus, Zika Virus Infection diagnosis
- Abstract
Objective: to confirm Zika virus circulation and discard other etiological agents in an outbreak occurred in the states of Rio Grande do Norte, Maranhão and Paraíba, in May, 2015., Methods: this is a case series descriptive study with residents in Natal-RN, Barra do Corda-MA, São Luis-MA and João Pessoa-PB, with 20 cases in each state, presenting rash, absent or mild fever and one of the following signs/symptoms: conjunctival hyperemia, arthralgia or limb edema; RT-PCR/isolation tests for Zika, enterovirus and respiratory viruses, and serology tests (dengue, rubella and parvovirus B19) were performed., Results: the main symptoms were rash (n=60), pruritus (n=54), and arthralgia (n=47); 51 individuals did not present fever; Zika virus was identified in 18 cases (12 in Paraíba, four in Maranhão and two in Rio Grande do Norte), and antibodies to dengue, in 14 cases., Conclusion: the symptoms were consistent with Zika virus fever; there was laboratory confirmation for Zika and dengue.
- Published
- 2016
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