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Your search keyword '"Fang, Juntao"' showing total 44 results
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44 results on '"Fang, Juntao"'

2. Boosting the Performance of Degraded Reads in RS-coded Distributed Storage Systems

Author

Xie, Tian, Fang, Juntao, wan, Shenggang, Xie, Changsheng, and He, Xubin

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing
Abstract

Reed-Solomon (RS) codes have been increasingly adopted by distributed storage systems in place of replication,because they provide the same level of availability with much lower storage overhead. However, a key drawback of those RS-coded distributed storage systems is the poor latency of degraded reads, which can be incurred by data failures or hot spots,and are not rare in production environments. To address this issue, we propose a novel parallel reconstruction solution called APLS. APLS leverages all surviving source nodes to send the data needed by degraded reads and chooses light-loaded starter nodes to receive the reconstructed data of those degraded reads. Hence, the latency of the degraded reads can be improved.Prototyping-based experiments are conducted to compare APLS with ECPipe, the state-of-the-art solution of improving the latency of degraded reads. The experimental results demonstrate that APLS effectively reduces the latency, particularly under heavy or medium workloads.

Published
2023

7. Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species

Author

Experimentele Afd. Cardiologie 2, CDL Nanomedicine, Experimentele Afd. Cardiologie 1, CDL Onderzoek Pasterkamp, Child Health, Circulatory Health, Onderzoek Cardiovasculair Reg. Med., Centraal Diagnostisch Laboratorium, Cancer, Regenerative Medicine and Stem Cells, Fang, Juntao, Yang, Qiangbing, Maas, Renée G C, Buono, Michele, Meijlink, Bram, Lotgerink Bruinenberg, Dyonne, Benavente, Ernest Diez, Mokry, Michal, van Mil, Alain, Qian, Li, Goumans, Marie-José, Schiffelers, Raymond, Lei, Zhiyong, Sluijter, Joost P G, Experimentele Afd. Cardiologie 2, CDL Nanomedicine, Experimentele Afd. Cardiologie 1, CDL Onderzoek Pasterkamp, Child Health, Circulatory Health, Onderzoek Cardiovasculair Reg. Med., Centraal Diagnostisch Laboratorium, Cancer, Regenerative Medicine and Stem Cells, Fang, Juntao, Yang, Qiangbing, Maas, Renée G C, Buono, Michele, Meijlink, Bram, Lotgerink Bruinenberg, Dyonne, Benavente, Ernest Diez, Mokry, Michal, van Mil, Alain, Qian, Li, Goumans, Marie-José, Schiffelers, Raymond, Lei, Zhiyong, and Sluijter, Joost P G

Published
2024

11. Cellular polyploidy in organ homeostasis and regeneration

Author

Fang, Juntao, de Bruin, Alain, Villunger, Andreas, Schiffelers, Raymond, Lei, Zhiyong, Sluijter, Joost P G, Fang, Juntao, de Bruin, Alain, Villunger, Andreas, Schiffelers, Raymond, Lei, Zhiyong, and Sluijter, Joost P G

Abstract

Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.

Published
2023

12. Cellular polyploidy in organ homeostasis and regeneration

Author

Pathobiologie, Dep Biomolecular Health Sciences, Cell Biology, Metabolism & Cancer - Cancer, Fang, Juntao, de Bruin, Alain, Villunger, Andreas, Schiffelers, Raymond, Lei, Zhiyong, Sluijter, Joost P G, Pathobiologie, Dep Biomolecular Health Sciences, Cell Biology, Metabolism & Cancer - Cancer, Fang, Juntao, de Bruin, Alain, Villunger, Andreas, Schiffelers, Raymond, Lei, Zhiyong, and Sluijter, Joost P G

Published
2023

14. Cellular polyploidy in organ homeostasis and regeneration

Author

Experimentele Afd. Cardiologie 2, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, CDL Nanomedicine, Onderzoek Cardiovasculair Reg. Med., Regenerative Medicine and Stem Cells, Fang, Juntao, de Bruin, Alain, Villunger, Andreas, Schiffelers, Raymond, Lei, Zhiyong, Sluijter, Joost P G, Experimentele Afd. Cardiologie 2, Centraal Diagnostisch Laboratorium, Cancer, Circulatory Health, CDL Nanomedicine, Onderzoek Cardiovasculair Reg. Med., Regenerative Medicine and Stem Cells, Fang, Juntao, de Bruin, Alain, Villunger, Andreas, Schiffelers, Raymond, Lei, Zhiyong, and Sluijter, Joost P G

Published
2023

17. Towards a sustainable urban form: a comparative analysis on urban regeneration between Crewe (UK) and Barahona de Fresno (Spain)

Author

Feliciotti, Alessandra, Fleischmann, Martin, Al-Saffar, Mazin, Blanco Pastor, Antonio, Tezer, Jale, Fang, Juntao, Livanur Sen, Hatice, Su, Zijun, Hussein, Malak, Feliciotti, Alessandra, Fleischmann, Martin, Al-Saffar, Mazin, Blanco Pastor, Antonio, Tezer, Jale, Fang, Juntao, Livanur Sen, Hatice, Su, Zijun, and Hussein, Malak

Abstract

This paper will explore different approaches to sustainable urban form through the comparative analysis of two different locations: Crewe in the UK and Barahona de Fresno in Spain. Despite these locations have different scales, shortcomings, and opportunities, both existing settlements share some issues like the abandonment, isolation, deterioration, or deprivation of the community, which, although experiencing many changes over time, still retain significant aspects of their architecture, urban, and ethnological heritage. In this context, both examples have been redesigned under the same umbrella of sustainable urban regeneration and conservation, by applying the proper treatment that each case requires. In order to cope with such a situation, the urban regeneration of both settlements have been relied on the conservation of their existing local identity, either tangible or intangible, by attempting to reduce the impact of new private or public spaces within or outside its existing urban fabric. Within this framework, the desired balance between the regeneration and conservation of Crewe and Barahona de Fresno has been the main aim of these academic projects, in order to reinvigorate these existing settlements from the standpoint of sustainable urban form.

Published
2022

18. Small molecule-mediated rapid maturation of human induced pluripotent stem cell-derived cardiomyocytes

Author

Experimentele Afd. Cardiologie 2, Circulatory Health, Experimentele Afd. Cardiologie 1, Onderzoek Cardiovasculair Reg. Med., Team Onderzoek, Regenerative Medicine and Stem Cells, CDL Nanomedicine, Team Medisch, Chirico, Nino, Kessler, Elise L, Maas, Renée G C, Fang, Juntao, Qin, Jiabin, Dokter, Inge, Daniels, Mark, Šarić, Tomo, Neef, Klaus, Buikema, Jan-Willem, Lei, Zhiyong, Doevendans, Pieter A, Sluijter, Joost P G, van Mil, Alain, Experimentele Afd. Cardiologie 2, Circulatory Health, Experimentele Afd. Cardiologie 1, Onderzoek Cardiovasculair Reg. Med., Team Onderzoek, Regenerative Medicine and Stem Cells, CDL Nanomedicine, Team Medisch, Chirico, Nino, Kessler, Elise L, Maas, Renée G C, Fang, Juntao, Qin, Jiabin, Dokter, Inge, Daniels, Mark, Šarić, Tomo, Neef, Klaus, Buikema, Jan-Willem, Lei, Zhiyong, Doevendans, Pieter A, Sluijter, Joost P G, and van Mil, Alain

Published
2022

19. Towards a sustainable urban form : a comparative analysis on urban regeneration between Crewe (UK) and Barahona de Fresno (Spain)

Author

Al-Saffar, Mazin, Pastor, Antonio Blanco, Tezer, Zhale, Fang, Juntao, Sen, Hatice Livanur, Su, Zijun, and Hussein, Malak

Subjects
NA
Abstract

This paper will explore different approaches to sustainable urban form through the comparative analysis of two different locations: Crewe in the UK and Barahona de Fresno in Spain. Despite these locations have different scales, shortcomings, and opportunities, both existing settlements share some issues like the abandonment, isolation, deterioration, or deprivation of the community, which, although experiencing many changes over time, still retain significant aspects of their architectural, urban, and ethnological heritage. In this context, both examples have been redesigned under the same umbrella of sustainable urban regeneration and conservation, by applying the proper treatment that each case requires. In order to cope with such a situation, the urban regeneration of both settlements have been relied on the conservation of their existing local identity, either tangible or intangible, by attempting to reduce the impact of new private or public spaces within or outside its existing urban fabric. Within this framework, the desired balance between the regeneration and conservation of Crewe and Barahona de Fresno has been the main aim of these academic projects, in order to reinvigorate these existing settlements from the standpoint of sustainable urban form.

Published
2022
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20. 89 The immune marker LAG-3 increases the predictive value of CD38+ immune cells for survival outcome in immunotherapy-treated hepatocellular carcinoma

Author

Lawrence Cheung, Chun Chau, primary, Justin Seah, Yong Hock, additional, Fang, Juntao, additional, Orpilla, Nicole, additional, Wen Lee, Justina Nadia Li, additional, Toh, Han Chong, additional, Choo, Su Pin, additional, Lim, Kiat Hon, additional, David Tai, Wai Meng, additional, and Yeong, Joe, additional

Published
2021
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23. Repairing the heart: State-of the art delivery strategies for biological therapeutics

Author

CDL Research analisten, CDL Nanomedicine, DHL-Zorg, Device, Circulatory Health, Onderzoek Cardiovasculair Reg. Med., Regenerative Medicine and Stem Cells, CDL Cluster Onderzoek en Onderwijs, Cancer, Yang, Qiangbing, Fang, Juntao, Lei, Zhiyong, Sluijter, Joost P G, Schiffelers, Raymond, CDL Research analisten, CDL Nanomedicine, DHL-Zorg, Device, Circulatory Health, Onderzoek Cardiovasculair Reg. Med., Regenerative Medicine and Stem Cells, CDL Cluster Onderzoek en Onderwijs, Cancer, Yang, Qiangbing, Fang, Juntao, Lei, Zhiyong, Sluijter, Joost P G, and Schiffelers, Raymond

Published
2020

24. Loss of miR-132/212 Has No Long-Term Beneficial Effect on Cardiac Function After Permanent Coronary Occlusion in Mice

Author

CDL Nanomedicine, Circulatory Health, Onderzoek Cardiovasculair Reg. Med., Experimentele Afd. Cardiologie 2, Arts Assistenten Cardiologie, Cardiologie, Team Medisch, Regenerative Medicine and Stem Cells, Lei, Zhiyong, Fang, Juntao, Deddens, Janine C, Metz, Corina H G, van Eeuwijk, Esther C M, El Azzouzi, Hamid, Doevendans, Pieter A, Sluijter, Joost P G, CDL Nanomedicine, Circulatory Health, Onderzoek Cardiovasculair Reg. Med., Experimentele Afd. Cardiologie 2, Arts Assistenten Cardiologie, Cardiologie, Team Medisch, Regenerative Medicine and Stem Cells, Lei, Zhiyong, Fang, Juntao, Deddens, Janine C, Metz, Corina H G, van Eeuwijk, Esther C M, El Azzouzi, Hamid, Doevendans, Pieter A, and Sluijter, Joost P G

Published
2020

25. Cellular and molecular mechanism of cardiac regeneration: A comparison of newts, zebrafish, and mammals

Author

Cardiologie, UMC Utrecht Holding, Experimentele Afd. Cardiologie 2, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, UMC Utrecht, Cancer, CDL Cluster Onderzoek en Onderwijs, CDL Nanomedicine, Divisie Beeld & Oncologie, Onderzoek Cardiovasculair Reg. Med., de Wit, Lousanne, Fang, Juntao, Neef, Klaus, Xiao, Junjie, Doevendans, Pieter A., Schiffelers, Raymond M., Lei, Zhiyong, Sluijter, Joost P.G., Cardiologie, UMC Utrecht Holding, Experimentele Afd. Cardiologie 2, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, UMC Utrecht, Cancer, CDL Cluster Onderzoek en Onderwijs, CDL Nanomedicine, Divisie Beeld & Oncologie, Onderzoek Cardiovasculair Reg. Med., de Wit, Lousanne, Fang, Juntao, Neef, Klaus, Xiao, Junjie, Doevendans, Pieter A., Schiffelers, Raymond M., Lei, Zhiyong, and Sluijter, Joost P.G.

Published
2020

32. The robustness of response surface designs with errors in factor levels.

Author

Fang, Juntao, He, Zhen, He, Shuguang, and Wang, Guodong

Subjects
*RESPONSE surfaces (Statistics), *FORECASTING, *FACTORIALS, *SURFACE properties, *EXPERIMENTAL design
Abstract

Since errors in factor levels affect the traditional statistical properties of response surface designs, an important question to consider is robustness of design to errors. However, when the actual design could be observed in the experimental settings, its optimality and prediction are of interest. Various numerical and graphical methods are useful tools for understanding the behavior of the designs. The D- and G-efficiencies and the fraction of design space plot are adapted to assess second-order response surface designs where the predictor variables are disturbed by a random error. Our study shows that the D-efficiencies of the competing designs are considerably low for big variance of the error, while the G-efficiencies are quite good. Fraction of design space plots display the distribution of the scaled prediction variance through the design space with and without errors in factor levels. The robustness of experimental designs against factor errors is explored through comparative study. The construction and use of the D- and G-efficiencies and the fraction of design space plots are demonstrated with several examples of different designs with errors. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Research on the Optimal Preventive Maintenance Cost of Electronic Equipments

Author

Hui Yi, Yuan Xin, Fang Juntao, and Zhang Ruixin

Subjects
Proactive maintenance, Recursion, Computer science, Planned maintenance, Failure rate, Preventive maintenance, Reliability (statistics), Predictive maintenance, Reliability engineering, Auto maintenance
Abstract

According to the characters of electronic equipments, a preventive maintenance model which minimize the preventive maintenance cost based on reliability constrains was built up. The recursion relationship of failure rate anterior-posterior preventive maintenance was built up concerning with the concept of age reduction factor in the model. The simulation results showed the effectiveness of the preventive maintenance model.

Published
2013
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39. Reliability improvement of diamond drill bits using design of experiments.

Author

Fang, Juntao, He, Zhen, Zhang, Zhaomin, and He, Shuguang

Subjects
EXPERIMENTAL design, RELIABILITY in engineering, DATA acquisition systems, SYSTEMS engineering, STATISTICAL models
Abstract

Design of experiments has received much attention in the context of reliability improvement. Many engineers and researchers are considering how to use designed experiments to improve the reliability of products and processes. This work illustrates a 12-run Plackett-Burman design and its analysis to improve the reliability of a diamond drill bit. A detailed description and execution of the design are provided including how to choose the factors and determine the number of experimental factors. In addition, the results of the real-world experiment are presented and the predicted performance from statistical model fitting is verified by part of a confirmation experiment. The experimental data show that the recommended factor settings substantially improved the reliability of the diamond drill bits. [ABSTRACT FROM AUTHOR]

Published
2018
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43. Cellular polyploidy in organ homeostasis and regeneration.

Author

Fang J, de Bruin A, Villunger A, Schiffelers R, Lei Z, and Sluijter JPG

Subjects
Humans, Cell Cycle, Polyploidy, Homeostasis, Liver, Hepatocytes
Abstract

Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues., (©The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.)

Published
2023
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44. Immunohistochemical scoring of LAG-3 in conjunction with CD8 in the tumor microenvironment predicts response to immunotherapy in hepatocellular carcinoma.

Author

Cheung CCL, Seah YHJ, Fang J, Orpilla NHC, Lau MC, Lim CJ, Lim X, Lee JNLW, Lim JCT, Lim S, Cheng Q, Toh HC, Choo SP, Lee SY, Lee JJX, Liu J, Lim TKH, Tai D, and Yeong J

Subjects
Humans, Tumor Microenvironment, CD8-Positive T-Lymphocytes, Immunotherapy methods, Carcinoma, Hepatocellular metabolism, Liver Neoplasms
Abstract

Introduction: Immune checkpoint blockade (ICB) is a systemic therapeutic option for advanced hepatocellular carcinoma (HCC). However, low patient response rates necessitate the development of robust predictive biomarkers that identify individuals who will benefit from ICB. A 4-gene inflammatory signature, comprising CD8 , PD-L1 , LAG-3 , and STAT1 , was recently shown to be associated with a better overall response to ICB in various cancer types. Here, we examined whether tissue protein expression of CD8, PD-L1, LAG-3, and STAT1 predicts response to ICB in HCC., Methods: HCC samples from 191 Asian patients, comprising resection specimens from 124 patients (ICB-naïve) and pre-treatment specimens from 67 advanced HCC patients treated with ICB (ICB-treated), were analyzed for CD8, PD-L1, LAG-3, and STAT1 tissue expression using multiplex immunohistochemistry followed by statistical and survival analyses., Results: Immunohistochemical and survival analyses of ICB-naïve samples showed that high LAG-3 expression was associated with shorter median progression-free survival (mPFS) and overall survival (mOS). Analysis of ICB-treated samples revealed that high proportions of LAG-3 + and LAG-3 + CD8 + cells pre-treatment were most closely associated with longer mPFS and mOS. Using a log-likelihood model, adding the total LAG-3 + cell proportion to the total CD8 + cell proportion significantly increased the predictive values for mPFS and mOS, compared with the total CD8 + cell proportion alone. Moreover, levels of CD8 and STAT1, but not PD-L1, were significantly correlated with better responses to ICB. After analyzing viral-related and non-viral HCC samples separately, only the LAG3 + CD8 + cell proportion was significantly associated with responses to ICB regardless of viral status., Conclusion: Immunohistochemical scoring of pre-treatment levels of LAG-3 and CD8 in the tumor microenvironment may help predict ICB benefits in HCC patients. Furthermore, immunohistochemistry-based techniques offer the advantage of being readily translatable in the clinical setting., Competing Interests: DT is in the advisory board in Novartis, Celgene, Sirtex, MSD, BMS, Eisai, Ipsen, and Bayer; and as research support in Novartis, Sirtex, and BMS. JJL received research funding from Bayer, has participated in the advisory boards for Eisai, Ipsen, and Bayer, and Taiho; and received honorarium from Ipsen and BMS. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest., (Copyright © 2023 Cheung, Seah, Fang, Orpilla, Lau, Lim, Lim, Lee, Lim, Lim, Cheng, Toh, Choo, Lee, Lee, Liu, Lim, Tai and Yeong.)

Published
2023
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