68 results on '"False positive finding"'
Search Results
2. Screening for Lung Cancer with Spiral CT
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Rifkin, Erik, Lazris, Andrew, Rifkin, Erik, and Lazris, Andrew
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- 2015
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3. Breast Cancer Screening: Mammograms
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Rifkin, Erik, Lazris, Andrew, Rifkin, Erik, and Lazris, Andrew
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- 2015
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4. Introduction
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Lin, Dan, Talloen, Willem, Bijnens, Luc, Göhlmann, Hinrich W. H., Amaratunga, Dhammika, Straetemans, Roel, Lin, Dan, editor, Shkedy, Ziv, editor, Yekutieli, Daniel, editor, Amaratunga, Dhammika, editor, and Bijnens, Luc, editor
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- 2012
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5. Detection and Classification of Suspicious Areas in Autofluorescence Bronchoscopy
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Bountris, P., Haritou, M., Passalidou, E., Apostolou, N., Koutsouris, D., Magjarevic, Ratko, Dössel, Olaf, editor, and Schlegel, Wolfgang C., editor
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- 2010
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6. Posttraumatic Scab on 131I Whole-Body Scan—A False-Positive Finding
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Bhagwant Rai Mittal, Anwin Joseph Kavanal, Sarika Prashar, Abdul Waheed Chowdhary, Ashwani Sood, Anish Bhattacharya, and Ritesh Upadhyay
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Adult ,Male ,medicine.medical_specialty ,False positive finding ,Whole body imaging ,Knee region ,Disease ,030218 nuclear medicine & medical imaging ,Iodine Radioisotopes ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,False Positive Reactions ,Whole Body Imaging ,Radiology, Nuclear Medicine and imaging ,Thyroid Neoplasms ,Thyroid cancer ,Pathological ,business.industry ,Thyroid ,General Medicine ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,Whole Body Scan ,Radiology ,business - Abstract
131I scan plays a crucial role in the management of patients with differentiated thyroid cancer for the evaluation of remnant thyroid tissue, residual/recurrent metastatic disease, posttherapy tracer distribution, and response assessment to high-dose 131I therapy. Different causes secondary to physiological, pathological, and anatomical variations have been described for false-positive findings in the whole-body planar images. This case report of a patient of differentiated thyroid cancer with undocumented trauma to the left knee region a day before receiving the high-dose radioiodine therapy showed an interesting image finding of tracer uptake at unusual site in the posttherapy whole-body 131I scan.
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- 2021
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7. Nuclear medicine in inflammatory bowel diseases
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Hotze, Andreas L., Biersack, Hans J., Cox, Peter H., editor, Wagner, Henry N., editor, Biersack, J., editor, and Cox, H., editor
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- 1991
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8. A Comparative Study of the Diagnostic Value of Telethermography and Contact Thermography in the Diagnosis of Varicocele
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Vlaisavljevič, Veljko and Zorgniotti, Adrian W., editor
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- 1991
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9. Peroneus brevis tendon injuries: Report of two cases and review of literature
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Thanos Badekas, Evangelos Triantafyllou, Dimitrios Pallis, Stamatios A. Papadakis, Margarita-Michaela Ampadiotaki, Nicholaos Trygonis, Dimitrios Artsitas, and Konstantinos Tsivelekas
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Peroneal tendon ,medicine.medical_specialty ,False positive finding ,RD1-811 ,Population ,Case Report ,Critical Care and Intensive Care Medicine ,Medicine ,Orthopedics and Sports Medicine ,education ,education.field_of_study ,business.industry ,Persistent pain ,Incidence (epidemiology) ,Peroneus brevis tendon ,Surgery ,medicine.anatomical_structure ,Tear ,Emergency Medicine ,Ankle ,Peroneus brevis ,business ,MRI - Abstract
The incidence of peroneal tendon disorders in the population is unknown and they are usually overlooked. We report two cases of peroneus brevis injuries and a comprehensive literature review was performed. The first case was a 53-year-old man presented with persistent pain on the lateral aspect on the left ankle during the last four years and difficulty to bear weight during the last year. MRI showed longitudinal tear of peroneus brevis tendon and the patient underwent surgical treatment. The second case was a 46-year-old woman with persistent pain on the lateral aspect of the ankle with a history of a road traffic accident two years ago. Although MRI showed a peroneus brevis tendon tear, this was a false positive finding. Surgical treatment revealed no tear and symphysiolysis managed to relieve patient's symptoms. Even though MRI is the most effective diagnostic tool in depicting peroneal tendon injuries, there are false positive findings. In cases when symptoms persist, surgical exploration is indicated.
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- 2021
10. The hot embolus of 18F-fluorodeoxyglucose
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Tariq Mahmood and Riffat Parveen Hussain
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Fluorodeoxyglucose ,lcsh:Medical physics. Medical radiology. Nuclear medicine ,medicine.medical_specialty ,Treatment response ,False positive finding ,Standard of care ,business.industry ,lcsh:R895-920 ,imaging pitfall ,hot clot ,Case Report ,False-positive finding ,Embolus ,medicine ,Radiology ,hot emboli ,business ,Disease staging ,medicine.drug - Abstract
Scanning oncological patients with 18F-fluorodeoxyglucose (18F-FDG) for their disease staging, evaluation of treatment response, and monitoring/management has become a standard of care. The use of the radioactive fluorine in the FDG molecule helps establish cell/tissue lines high on glucose consumption and hence metabolically active. Abnormalities are detected on the scan as areas of increased uptake. However, these areas of increased (hot) uptakes do not necessarily translate into a pathological finding. A comprehensive knowledge of the uptakes of the tracer and the potential “pitfalls” that may be associated with them should be known and kept in mind during scan reading. One such pitfall is the “hot clot” or “pulmonary emboli,” and we report two such cases encountered at our setup and discuss their causes and how they should be identified and avoided.
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- 2020
11. Moon and suicide : a true effect or a false-positive finding?
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Martin Plöderl and Michael Hengartner
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Cellular and Molecular Neuroscience ,Psychiatry and Mental health ,False positive finding ,Text mining ,business.industry ,MEDLINE ,business ,Psychology ,616.89: Psychische Störungen, klinische Psychologie und Psychiatrie ,Molecular Biology ,Clinical psychology - Abstract
This paper is a response to the study of Meyer-Rochow et al. (2020), who found a statistically significant increase of suicides during full moon among women in the region of Oulu, Finland. We argue that this may be a false-positive finding because of subgroups not specified a-priori and the many negative previous findings. Furthermore, we could not replicate the findings in a larger Austrian sample.
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- 2020
12. False-Positive Cholesteatomas on Non-Echoplanar Diffusion-Weighted Magnetic Resonance Imaging
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Omid Moshtaghi, Hossein Mahboubi, Ethan G Muhonen, Marlon Maducdoc, Yaser Ghavami, Hamid R. Djalilian, Ronald Sahyouni, and Harrison W. Lin
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False positive finding ,medicine.medical_specialty ,Diffusion-weighted magnetic resonance imaging ,Non-echoplanar diffusion weighted imaging ,Clinical Sciences ,Half-Fourier acquisition single-shot turbo spin echo ,Sensitivity and Specificity ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Clinical Research ,medicine ,Humans ,030223 otorhinolaryngology ,Cholesteatoma ,Retrospective Studies ,Surveillance ,medicine.diagnostic_test ,Cholesteatoma, Middle Ear ,business.industry ,Middle Ear ,Retrospective cohort study ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Sensory Systems ,Diffusion-Weighted Magnetic Resonance Imaging ,Intensity (physics) ,Diffusion Magnetic Resonance Imaging ,Recidivism ,Otorhinolaryngology ,Public Health and Health Services ,Biomedical Imaging ,Neurology (clinical) ,Radiology ,medicine.symptom ,business ,Zoology ,030217 neurology & neurosurgery ,Diffusion MRI ,Follow-Up Studies - Abstract
Author(s): Muhonen, Ethan G; Mahboubi, Hossein; Moshtaghi, Omid; Sahyouni, Ronald; Ghavami, Yaser; Maducdoc, Marlon; Lin, Harrison W; Djalilian, Hamid R | Abstract: ObjectivesTo investigate false-positive findings on non-echoplanar (non-EPI) diffusion-weighted magnetic resonance imaging (DWI) in patients under surveillance post-cholesteatoma surgery.Study design, setting, subjects, and methodsA retrospective review was performed on patients diagnosed with cholesteatoma who underwent surgical resection and were then followed by serial non-EPI DWI using half-Fourier acquisition single-shot turbo spin echo (HASTE) sequence. All patients had at least two annual follow-up imaging studies.ResultsFalse-positive findings were identified in four patients. The size of the suspected lesions was 4 to 12 mm. Otoendoscopy was used during all primary cases and Argon laser was used in one case. In all cases, the entire cholesteatoma was removed, and no residual disease was detected at the end of the procedures. One patient underwent revision surgery but only cartilage graft was found in the area of concern. All patients had stable or resolved hyperintense areas in the subsequent HASTE sequences.ConclusionFalse positive findings can occur with non-EPI DWI MRI and patients need to be counseled accordingly before revision surgery. Decreasing intensity and dimension of a suspected lesion and a positive finding in an area other than the location of the initial cholesteatoma may favor a false positive. If a false positive finding is suspected when the surgeon is confident of complete resection of the cholesteatoma, an MRI can be repeated in 6 to 12 months to assess changes in the dimension and intensity of the area of concern. Cartilage grafts may cause restricted diffusion on DWI sequences.
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- 2020
13. False positive finding from malignancy-like lesions on FDG PET/CT: case report of tuberculosis patients
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Hendra Budiawan, Febby Hutomo, Ryan Yudistiro, and Ivana Dewi Mulyanto
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Male ,False positive finding ,medicine.medical_specialty ,lcsh:Medical technology ,Tuberculosis ,FDG ,PET/CT ,Biopsy ,Antitubercular Agents ,Case Report ,Malignancy ,Asymptomatic ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Medical imaging ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Fluorodeoxyglucose ,PET-CT ,business.industry ,Middle Aged ,medicine.disease ,Treatment Outcome ,lcsh:R855-855.5 ,030220 oncology & carcinogenesis ,Female ,Radiology ,Differential diagnosis ,medicine.symptom ,business ,medicine.drug - Abstract
Background The F-18 fluorodeoxyglucose positron emission/computed tomography (FDG PET/CT) has become an established diagnostic imaging for malignancy. However, there are other diseases that can also be identified with FDG, some of them are infections such as tuberculosis. Case presentation In this case report, two patients showed multiple hypermetabolic tuberculosis lesions on FDG PET/CT, with one of the patients having history of malignancy. The objective of the present case report is to emphasize the need to use other differential diagnosis techniques for tuberculosis especially in tuberculosis-endemic countries when interpreting FDG PET/CT. Conclusion By analyzing diagnostic imaging alone, there is a high chance of misinterpreting asymptomatic tuberculosis patient as having malignancy. Therefore, there is need for correlation with clinical data as well as other imaging modalities and PET/CT with more specific tracer in order to differentiate malignancy from benign disease such as tuberculosis.
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- 2020
14. Meningioma: A false positive finding of metastasis from prostate adenocarcinoma using 68Ga-PSMA PET/CT scan
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Kamran Aryana, Hojjat Ahmadzadefar, Atena Aghaei, Roham Salek, and Seyed Rasoul Zakavi
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Prostate adenocarcinoma ,False positive finding ,PET-CT ,business.industry ,Prostatectomy ,medicine.medical_treatment ,68ga psma ,medicine.disease ,Metastasis ,Meningioma ,Prostate cancer ,medicine ,Radiology, Nuclear Medicine and imaging ,Nuclear medicine ,business - Abstract
A 73-year-old man with history of prostatic adenocarcinoma radical prostatectomy underwent 99mTc-MDP whole-body bone scan and subsequent 68Ga-labeled prostate-specific membrane antigen (PSMA) ligand PET/CT for restaging due to a gradual rise of prostate-specific antigen levels. Whole-body bone scan showed two focal zones of slightly increased uptake in the right fronto-parietal and temporal bones. 68Ga-PSMA PET/CT scan showed local recurrence in the prostatic bed and two foci of slightly increased uptake in the right temporal and fronto-parietal lobes. A brain CT scan, with IV contrast confirmed that foci of increased uptake in the temporal and parietal lobes were consistent with typical meningioma.
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- 2019
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15. EBV VCA IgM and cytomegalovirus IgM dual positivity is a false positive finding related to age and hepatic involvement of primary Epstein–Barr virus infection in children
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Jin Soo Moon, Jin Min Cho, Hye Ran Yang, Min Ji Sohn, and Jae Sung Ko
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0301 basic medicine ,Male ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,Cytomegalovirus ,medicine.disease_cause ,Antibodies, Viral ,0302 clinical medicine ,hemic and lymphatic diseases ,Child ,Antigens, Viral ,biology ,Coinfection ,Liver Diseases ,Age Factors ,virus diseases ,General Medicine ,false positivity ,epstein–barr virus ,Hepatic Involvement ,Child, Preschool ,Cytomegalovirus Infections ,Female ,Antibody ,psychological phenomena and processes ,Research Article ,False positive finding ,Adolescent ,030106 microbiology ,Congenital cytomegalovirus infection ,Observational Study ,liver ,Virus ,03 medical and health sciences ,Antigen ,030225 pediatrics ,mental disorders ,medicine ,Humans ,False Positive Reactions ,Epstein–Barr virus infection ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Epstein–Barr virus ,age ,Immunoglobulin M ,Immunology ,biology.protein ,Capsid Proteins ,business - Abstract
Primary Epstein–Barr virus (EBV) infection is common in childhood, and dual positivity of serum EBV IgM and cytomegalovirus (CMV) IgM antibodies occur in some cases. This study aimed to evaluate the cause of EBV and CMV IgM dual positivity to determine whether it represents a false-positive finding or a true coinfection. A total of 494 children diagnosed with primary EBV infection, manifesting as infectious mononucleosis, were recruited. The diagnosis was based on positive EBV viral capsid antigen (VCA) IgM antibodies, and serum CMV IgM antibodies and liver enzymes were also evaluated in 149 subjects. Of 149 children with primary EBV infection, 40 (26.8%) had serum EBV VCA IgM and CMV IgM dual positivity. However, true CMV infection was confirmed only in 1 child of 40 (2.5%) who was positive for both serum CMV Ag and urine CMV polymerase chain reaction (PCR) and negative for serum CMV IgG antibody. Among the children with primary EBV infection, the rate of dual positivity was higher in infants and lower in adolescents (P = .013). Liver enzymes were more significantly elevated in children with dual positivity than in those with negative results for CMV IgM antibodies (P = .026), which correlated with the serum EBV and CMV IgM titers. Serum EBV and CMV IgM dual positivity are more prevalent in children with primary EBV infection than what was previously reported. Our results indicate that serum EBV and CMV IgM dual positivity represents a false-positive finding, as opposed to an actual CMV coinfection, possibly due to antigenic cross-reactivity.
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- 2018
16. Reanalysis of an oft-cited paper on honeybee magnetoreception reveals random behavior
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Michael J. Baltzley and Matthew Nabity
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0301 basic medicine ,False positive finding ,Behavior, Animal ,Physiology ,Computer science ,Magnetoreception ,Aquatic Science ,Bees ,Outcome (probability) ,03 medical and health sciences ,030104 developmental biology ,Magnetic Fields ,Research Design ,Insect Science ,Replication (statistics) ,Animals ,Animal Science and Zoology ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Cognitive psychology ,Probability - Abstract
While mounting evidence indicates that a phylogenetically diverse group of animals detect Earth-strength magnetic fields, a magnetoreceptor has not been identified in any animal. One possible reason that identifying a magnetoreceptor has proven challenging is that, like many research fields, magnetoreception research lacks extensive independent replication. Independent replication is important because a subset of studies undoubtedly contain false positive results and without replication it is difficult to determine if the outcome of an experiment is a false positive. However, we report here a reanalysis of a well-cited paper on honeybee magnetoreception demonstrating that the original paper represented a false positive finding caused by a misunderstanding of probability. We also point out how good experimental design practices could have revealed the error prior to publication. Hopefully, this reanalysis will serve as a reminder of the importance of good experimental design in order to reduce the likelihood of publishing false positive results.
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- 2018
17. Non-echo-planar diffusion-weighted MRI in cholesteatoma: One typical case, one atypical case and one rare false positive finding
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Manfred Kessler, Martin W. Huellner, Eva Novoa, Thomas C. Treumann, and Thomas E. Linder
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medicine.medical_specialty ,False positive finding ,business.industry ,Cholesteatoma ,General Medicine ,medicine.disease ,Rare case ,otorhinolaryngologic diseases ,medicine ,Radiology ,Differential diagnosis ,business ,Echo planar ,Diffusion MRI - Abstract
We present two cases of cholesteatoma and one false positive finding in non-EP DW MRI in order to highlight the differential diagnosis in imaging and emphasize the need to discuss the findings with the otologic surgeon. The first case demonstrates different MRI signal patterns encountered in a patient with cholesteatoma. The second report is a rare case of supralabyrinthine cholesteatoma with atypical clinical presentation. The third case presents a rare but important false positive finding in non-EP DW MRI. Clinical and imaging findings are discussed taking into account the current literature.
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- 2013
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18. Parallel or Crossover Designs in Evaluation of Antiarrhythmic Therapy
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Kraemer, Helena Chmura, Morganroth, Joel, editor, Moore, E. Neil, editor, Dreifus, Leonard S., editor, and Michelson, Eric L., editor
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- 1981
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19. False-Positive Finding on 18F FDG PET/CT: Report of a Rare Case With Xanthogranulomatous Inflammation in the Spinal Epidural Space
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Mohammed Shah Alam, Quanshi Wang, Hubing Wu, Wenlan Zhou, and Wei Guan
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Epidural Space ,Male ,medicine.medical_specialty ,False positive finding ,Lymphoma ,Spinal epidural space ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Rare case ,medicine ,Xanthomatosis ,Humans ,Radiology, Nuclear Medicine and imaging ,False Positive Reactions ,Inflammation ,Granuloma ,business.industry ,Fdg uptake ,General Medicine ,Middle Aged ,medicine.disease ,carbohydrates (lipids) ,Spinal epidural ,030220 oncology & carcinogenesis ,Positron-Emission Tomography ,Fdg pet ct ,Radiology ,Xanthogranulomatous inflammation ,Radiopharmaceuticals ,business ,Tomography, X-Ray Computed - Abstract
Xanthogranulomatous inflammation in the spinal epidural space is extremely rare. We report a case of a 62-year-old man with a xanthogranulomatous inflammation in the spinal epidural space mistaken for lymphoma because of its avid F FDG uptake on PET/CT. This case emphasizes the need for caution when evaluating a spinal epidural mass using F FDG PET/CT as xanthogranulomatous inflammation can induce a false-positive reading on F-FDG PET/CT.
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- 2016
20. A False Positive Dengue Fever Rapid Diagnostic Test Result in a Case of Acute Parvovirus B19 Infection
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Toshihide Izumida, Takenori Takizawa, Ryo Inahata, Hidenao Sakata, Masahiko Nakamura, Sumiyo Hasegawa, Noriko Inasaki, Yumiko Hayashibara, and Hiroyasu Kaya
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Male ,medicine.medical_specialty ,False positive finding ,viruses ,030231 tropical medicine ,Erythema Infectiosum ,Antibodies, Viral ,Dengue fever ,Disease Outbreaks ,Dengue ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Epidemiology ,Internal Medicine ,medicine ,Parvovirus B19, Human ,Humans ,False Positive Reactions ,030212 general & internal medicine ,Rapid diagnostic test ,biology ,Parvovirus ,business.industry ,virus diseases ,Outbreak ,General Medicine ,Middle Aged ,biology.organism_classification ,medicine.disease ,Virology ,False-positive result ,Immunoglobulin M ,biology.protein ,business - Abstract
An outbreak of dengue fever occurred in Japan in August 2014. We herein report the case of a 63-year-old man who presented with a persistent fever in September 2014. Acute parvovirus B19 infection led to a false positive finding of dengue fever on a rapid diagnostic test (Panbio Dengue Duo Cassette(TM)). To the best of our knowledge, there are no previous reports of a false positive result for dengue IgM with the dengue rapid diagnostic test. We believe that epidemiological information on the prevalence of parvovirus B19 is useful for guiding the interpretation of a positive result with the dengue rapid diagnostic test.
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- 2016
21. Forensically Robust Determination of the Illegal Dye Dimethyl Yellow in a Refractory Curcuma Oleoresin–Surfactant Matrix—a Case Study
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Peter Colwell, Duncan Thorburn Burns, Michael Walker, Sabine Biesenbruch, and Brian Stuart
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False positive finding ,Chromatography ,Resolution (mass spectrometry) ,biology ,biology.organism_classification ,Applied Microbiology and Biotechnology ,Analytical Chemistry ,Gel permeation chromatography ,chemistry.chemical_compound ,chemistry ,Pulmonary surfactant ,Lc ms ms ,Complex Extracts ,Oleoresin ,Curcuma ,Safety, Risk, Reliability and Quality ,Safety Research ,Food Science - Abstract
The presence of illegal dyes such as the Sudan reds in spices is a well-recognised problem, and numerous methods of analysis have been described for their determination. However, some spice-derived matrices present particular problems. Oleoresins, complex extracts of spices containing phenolic natural pigments and terpene-like lipids, are used in the formulation of oriental sauces, pickles and processed spiced meals and hence likely to penetrate far into the food chain. Described herein is a case in which a false positive finding of one of the less commonly used illegal dyes in an oleoresin had the potential to trigger a costly food recall. Rapid resolution of the false positive by liquid chromatography–tandem mass spectrometry (LC-MS/MS) came at the cost of subsequent decontamination of the instrument, incurring significant downtime. The analytical difficulties posed by the presence of a surfactant to improve oleoresin dispersive properties with other foods are discussed. We conclude that as LC-UV methods cannot deal with the possible matrix interferences, they must not be used for the analyses of illegal dyes in spice oleoresins. A combination of gel permeation chromatography with liquid–liquid and solid-phase cleanup is described that enables facile deployment of LC-MS/MS to an oleoresin–surfactant matrix for the forensically robust determination of dimethyl yellow at concentrations below the current “action limit” for illegal dyes of 500 μg kg−1.
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- 2012
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22. Racial Differences and the Probability of C2orf16 rs191912 to be the Major Gene Locus of General Cognitive Ability
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Volkmar Weiss
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False positive finding ,Arts and Humanities (miscellaneous) ,Anthropology ,Locus (genetics) ,Racial differences ,Psychology ,Major gene ,Gene ,Allele frequency ,humanities ,Developmental psychology - Abstract
By applying the logic of genetics and available knowledge on allele frequencies it is possible to put forward hypotheses on genes underlying IQ by data mining. At the present state of knowledge the probability of a false positive finding that C2orf16 rs1919128 is the major gene of IQ is about 0.000005
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- 2011
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23. 18F-FDG avid Sclerosing Angiomatoid Nodular Transformation (SANT) of spleen on PET-CT — a rare mimicker of metastasis
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Punit Sharma
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Dense connective tissue ,False positive finding ,Pathology ,medicine.medical_specialty ,Usually asymptomatic ,Spleen ,030218 nuclear medicine & medical imaging ,Metastasis ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Neoplasm Metastasis ,PET-CT ,Histiocytoma, Benign Fibrous ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Benign Vascular Tumor ,Female ,business - Abstract
Sclerosing Angiomatoid Nodular Transformation (SANT) is a rare benign vascular tumor of spleen. It consists of multiple angiomatoid nodules surrounded by dense fibrous tissue that often coalesces centrally to form a scar, which is considered to be a characteristic feature. These are usually asymptomatic and incidentally detected on imaging for other underlying pathology. SANTs can be 18F-Fluorodeoxyglucose (18F-FDG) avid on positron emission tomography-computed tomography (PET-CT) and thus can lead to false positive finding in oncological patients.
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- 2018
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24. A CASE OF FALSE-POSITIVE FINDING OF TUMOR MARKER AFTER GASTRECTOMY FOR GASTRIC CANCER, WITH CHANGE OF CEA IN PARALLEL WITH GLUCOSE TOLERANCE
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Kohji Miyazaki, Takao Ohtsuka, Seiji Sato, Yoshihiko Kitajima, and Yuji Nakafusa
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Oncology ,medicine.medical_specialty ,False positive finding ,business.industry ,medicine.medical_treatment ,Internal medicine ,Medicine ,Cancer ,Gastrectomy ,business ,medicine.disease ,Tumor marker - Abstract
症例は58歳,男性.胃上部2型進行癌に対し胃全摘術,D2リンパ節郭清,脾・膵尾部合併切除術を行った.病理組織学的に低分化型腺癌で,深達度SS,2群リンパ節に転移を認め,T2,N2,H0,P0,CY0,M0,Stage IIIB,根治度Bであった.5年前より狭心症と糖尿病のため内服治療中であったがいずれもコントロール良好であった.術前の腫瘍マーカーCEA値は3.3ng/mLと正常範囲内であった.術後2カ月目よりCEA値の増加および空腹時血糖値の上昇を認めた.術後4カ月目にはCEA 12.0ng/mL,空腹時血糖232mg/dL,HbA1c 8.6となった.画像評価を行うも明らかな再発病変を同定できなかったため,無治療のまま厳重に経過観察をすることとした.同時に食事・内服療法による糖尿病の治療も開始した.以後血糖コントロールの安定とともに腫瘍マーカー値は漸減していった.術後4年3カ月の現在まで無再発生存中である.
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- 2009
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25. Evaluation of a new expert system for fully automated detection of the Alzheimer's dementia pattern in FDG PET
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Ralph Buchert, Janos Mester, Daniel von Borczyskowski, Malte Clausen, Brigitte Martin, Florian Wilke, and Winfried Brenner
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Male ,False positive finding ,Expert Systems ,Statistical parametric mapping ,Automation ,Alzheimer Disease ,Fluorodeoxyglucose F18 ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Alzheimer s dementia ,Diagnosis, Computer-Assisted ,Aged ,Fluorodeoxyglucose ,medicine.diagnostic_test ,business.industry ,General Medicine ,Middle Aged ,Radiography ,Fully automated ,Positron emission tomography ,Data Interpretation, Statistical ,Positron-Emission Tomography ,Transmission Scan ,Female ,Radiopharmaceuticals ,Nuclear medicine ,business ,Correction for attenuation ,Software ,medicine.drug - Abstract
Objective Fluorodeoxyglucose (FDG) positron emission tomography (PET) is increasingly used to support a diagnosis of Alzheimer's disease. The aim of the present study was to evaluate a new expert system (PALZ) for the fully automated analysis of FDG PET images for diagnosis of the disease. Methods The PALZ tool is based on the detection of the typical disease pattern in FDG PET images. Its potential for this task was evaluated in 22 consecutive patients with suspected Alzheimer's disease who had been graded as positive for the pattern by an experienced reader (visual analysis supported by statistical parametric mapping (SPM)), and in 18 controls. Dependence on scanner performance was assessed by variation of the spatial resolution of the PET images. Results All the Alzheimer's disease subjects were classified as pattern-positive by the PALZ tool. Fifteen controls were classified as normal. Sensitivity and specificity for differentiation of the patients with suspected Alzheimer's disease from the controls were 100% and 83%, respectively. The false positive finding in three controls most likely was caused by differences in attenuation correction between the normal data base of the PALZ tool (cold transmission scan) and the local data sets (hot transmission scan). There was only mild dependence on spatial resolution. Conclusions The results of the present study suggest that the PALZ tool provides similar performance for the detection of the typical Alzheimer's disease pattern in FDG PET images as an experienced reader supported by SPM. The PALZ tool is fully automated, easy to use, and insensitive to the spatial resolution of the PET scanner used. Therefore, it has the potential for widespread clinical use.
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- 2006
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26. Comparison of functional imaging in multiple myeloma patients: Indication for hybrid-imaging with PET/MRI?
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Mosebach, J, Sachpekidis, C, Hillengass, J, Haberkorn, U, Dimitrakopoulou-Strauss, A, Schlemmer, H-P, and Delorme, S
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- 2015
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27. Bronchial anthracofibrosis: a potential false-positive finding on F-18 FDG PET
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Sang Eun Kim, Jong Jin Lee, Hongyoon Choi, and Yu Kyeong Kim
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medicine.medical_specialty ,False positive finding ,Fluorodeoxyglucose F18 ,medicine ,Humans ,False Positive Reactions ,Radiology, Nuclear Medicine and imaging ,Obstructive lesion ,Radiologic Finding ,medicine.diagnostic_test ,Pigmentation ,business.industry ,Pneumoconiosis ,Cancer ,Bronchial Diseases ,General Medicine ,Middle Aged ,respiratory system ,F 18 fdg pet ,medicine.disease ,respiratory tract diseases ,Positron emission tomography ,Positron-Emission Tomography ,Hypermetabolism ,Female ,Radiology ,business - Abstract
Bronchial anthracofibrosis characterized by bronchostenosis associated with anthracotic pigmentation in bronchoscopic finding without a relevant history of pneumoconiosis or smoking has been recently described as a clinical entity. Radiologic finding of bronchial obstructive lesion and mediastinal lymph nodes in bronchial anthracofibrosis can be mimicking cancer. However, the metabolic characteristics of bronchial anthracofibrosis have hardly been reported. Here, we report a case of bronchial anthracofibrosis which showing hypermetabolism on F-18 FDG PET.
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- 2012
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28. Oncocytoma of the Parotid Gland: A Potential False-Positive Finding on 18F-FDG PET
- Author
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Vinil Shah and Barton F. Branstetter
- Subjects
Male ,medicine.medical_specialty ,False positive finding ,Adenocarcinoma ,Neoplasms, Multiple Primary ,Fluorodeoxyglucose F18 ,medicine ,Adenoma, Oxyphilic ,Humans ,False Positive Reactions ,Radiology, Nuclear Medicine and imaging ,Oncocytoma ,Diagnostic Errors ,Aged ,medicine.diagnostic_test ,Salivary gland ,business.industry ,Head and neck cancer ,Cancer ,General Medicine ,medicine.disease ,Parotid Neoplasms ,Parotid gland ,medicine.anatomical_structure ,Head and Neck Neoplasms ,Positron emission tomography ,Positron-Emission Tomography ,Radiology ,Radiopharmaceuticals ,business - Abstract
WEB This is a Web exclusive article. ET with 18F-FDG has been successfully used for the diagnosis, management, and follow-up of many malignant tumors. PET is particularly useful for staging of head and neck tumors and for detecting recurrence [1]. Its utility in other settings, however, such as detection of non–squamous cell cancer of the head and neck and differentiating benign salivary gland tumors from malignant ones, is limited [2, 3]. This lack of usefulness may partly be explained by the poor anatomic localization of PET combined with variable physiologic uptake of FDG in the head and neck. These factors decrease the specificity of PET for head and neck cancer and thus increase the rate of false-positive findings. Combined PET/CT scanners, which fuse the functional data of PET with the anatomic data of CT, have shown promise in the evaluation of cancer of the head and neck [4]. Non–squamous cell cancer of the head and neck, particularly salivary gland tumors, however, have not been studied extensively with either PET or combined PET/CT. In cases that have been studied, the variable uptake from salivary gland tumors often causes false-negative results [4–6]. In addition, some benign tumors of the salivary glands, particularly Warthin’s tumor, show focal FDG uptake leading to false-positive results [2]. These false-positive findings reduce the utility of PET in differentiating benign salivary gland tumors from malignant tumors. We report a case of a benign parotid oncocytoma that had marked FDG avidity on PET/CT.
- Published
- 2007
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29. Diagnostic of non-palpable testis in children: laparoscopy or magnetic resonance imaging?
- Author
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U. Humke, Stefan Siemer, L. Bonnet, Manfred Ziegler, and M. Uder
- Subjects
False positive finding ,medicine.medical_specialty ,Diagnostic methods ,medicine.diagnostic_test ,business.industry ,Urology ,Negative Finding ,Magnetic resonance imaging ,Optical quality ,Abdominal testis ,Medicine ,Non palpable ,Radiology ,business ,Laparoscopy - Abstract
Laparoscopy and magnetic resonance imaging (MRI) are competetive tools in the diagnostic of non-palpable testis. Advantages and disadvantages of this methods will be demonstrate. 29 boys investigated for this indication with MRI. In case MRI failed to locate the testis laparoscopy was performed with a new miniaturized set of pediatric instruments (1.9 mm optic). The aim of laparoscopy was the identification of the spermatic duct and vessels and their topographic relation to the internal inguinal ring. All findings were verified by open surgical procedures. MRI revealed 10 inguinal and 7 abdominal testis. There was no false positive finding. In 12 boys MRI showed no testis. 4 cases were correct negative, 8 cases were false negative (32 %). In these 8 MRI-negative patients laparoscopy revealed 7 inguinal and 1 abdominal testis. The optical quality of the mini-telescope was sufficient for a 100 % correct diagnosis. Laparoscopy related complications did not occur. Laparoscopy proved to be a powerful low risk diagnostic method in non- palpable testis with high senitivity and specifity (100 % correct positive, 0 % false negative). Therefore lapraroscopy is recommended as primary diagnostic access for this indication. In the same anesthesia a optimal therapy is possible. Nevertheless a positive MRI-finding locates the testis reliably, whereas a negative finding always needs further exploration because testis might have been missed.
- Published
- 1998
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30. An exceptional false-positive finding in the postsurgical I 131 whole body scan of a differentiated thyroid carcinoma caused by an extralobar pulmonary sequestration
- Author
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Ignacio Banzo, F. Ortega-Nava, Zully Bravo, Julio Jiménez-Bonilla, José A. Amado, José M. Carril, Remedios Quirce, Rosangie Del Castillo-Matos, Javier Gómez, and Isabel Martínez-Rodríguez
- Subjects
Adult ,Pathology ,medicine.medical_specialty ,False positive finding ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Whole body imaging ,Lung pathology ,Biochemistry ,Pulmonary sequestration ,Thyroid carcinoma ,Iodine Radioisotopes ,Endocrinology ,Internal medicine ,medicine ,Humans ,Radionuclide imaging ,False Positive Reactions ,Whole Body Imaging ,Bronchopulmonary Sequestration ,Thyroid Neoplasms ,Radionuclide Imaging ,Lung ,business.industry ,Biochemistry (medical) ,Carcinoma ,medicine.disease ,Whole Body Scan ,Female ,Radiopharmaceuticals ,business ,Well Differentiated Thyroid Carcinoma - Published
- 2013
31. The false-positive finding of left pulmonary Kimura disease on 18F-FDG PET/CT
- Author
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Feng-Hua Zhan, Dong Li, Chun-Jiang Dang, and Ya-Jun Li
- Subjects
Male ,medicine.medical_specialty ,False positive finding ,business.industry ,Angiolymphoid Hyperplasia with Eosinophilia ,General Medicine ,Middle Aged ,Chronic inflammatory disorder ,Left pulmonary hilum ,Thoracotomy ,Fluorodeoxyglucose F18 ,Positron-Emission Tomography ,medicine ,Soft tissue mass ,Humans ,Radiology, Nuclear Medicine and imaging ,Kimura Disease ,Histopathology ,Fdg pet ct ,False Positive Reactions ,Radiology ,Differential diagnosis ,business ,Tomography, X-Ray Computed ,Lung - Abstract
Kimura disease is a chronic inflammatory disorder that occurs mainly in Asians. We present a patient with pulmonary Kimura disease assessed by whole-body 18F-FDG PET/CT examination and proved by pathologic findings. Chest x-ray detected left pulmonary hilum enlargement in a 49-year-old Chinese man. CT showed a soft tissue mass with punctate calcifications in the left pulmonary hilum, which obviously and homogeneously accumulated tracer on FDG PET. Histopathology findings showed characteristic of Kimura disease. Kimura disease should be included in the differential diagnosis of a pulmonary hilar tumor.
- Published
- 2013
32. Teflon Injection for Vocal Cord Paralysis: False-Positive Finding on FDG PET–CT in a Patient with Non–Small Cell Lung Cancer
- Author
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Donald A. Podoloff, Jeremy J. Erasmus, Homer A. Macapinlac, and Mylene T. Truong
- Subjects
False positive finding ,Lung Neoplasms ,Neurological disorder ,Injections, Intralesional ,Carcinoma, Non-Small-Cell Lung ,medicine ,Humans ,False Positive Reactions ,Radiology, Nuclear Medicine and imaging ,Vocal cord paralysis ,Lung cancer ,Laryngeal Neoplasms ,Polytetrafluoroethylene ,medicine.diagnostic_test ,business.industry ,Respiratory disease ,General Medicine ,medicine.disease ,Positron emission tomography ,Fdg pet ct ,Non small cell ,Tomography, X-Ray Computed ,Nuclear medicine ,business ,Vocal Cord Paralysis ,Tomography, Emission-Computed - Published
- 2004
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33. Deficient performance of drugs of abuse testing in Sweden: an external control study
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Olof Beck and P. Lafolie
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Narcotics ,Drug ,medicine.medical_specialty ,False positive finding ,Drugs of abuse ,media_common.quotation_subject ,Sample (material) ,Clinical Biochemistry ,Urine ,Lorazepam ,Gas Chromatography-Mass Spectrometry ,Biological fluid ,Cocaine ,Internal medicine ,medicine ,Humans ,False Positive Reactions ,Ephedrine ,Test sample ,media_common ,Sweden ,Cannabinoids ,business.industry ,Amphetamines ,General Medicine ,Surgery ,Substance Abuse Detection ,business ,medicine.drug - Abstract
Testing for drugs of abuse in urine is usually performed in two steps; after initial screening positive findings are confirmed with specific chromatographic techniques. The use of different methods with different cut-off levels, may lead to variable results in a test sample containing a drug. Sixty-eight Swedish laboratories were enrolled in an external quality study and received three control samples. The laboratories were instructed to perform only in-house tests for amphetamines, benzodiazepines, cannabinoids, cocaine and opiates. Nineteen out of the 68 laboratories reported fully correct results. Thirty reported one o more false positive drug findings. One laboratory performing confirmation with gas chromatography--mass spectrometry reported a false positive finding of amphetamines in the sample containing ephedrine. Since testing for drugs of abuse in urine is a delicate matter, with both medical and legal implications, such testing should be performed with a zero rate of false positive results. Routine use of specific methods for confirmation should be used since performance of these laboratories was better in this study. It is concluded that there is a need to continuously measure the level of quality of laboratories by a program for external quality control.
- Published
- 1994
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34. Benign epithelial cyst mimicking thyroid cancer metastasis: a false-positive finding on post-therapy I-131 scan
- Author
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James M. Mountz, Gonca G Bural, and Robert L. Peel
- Subjects
Oncology ,Male ,medicine.medical_specialty ,False positive finding ,business.industry ,Epidermal Cyst ,General Medicine ,medicine.disease ,Peritoneal Diseases ,Carcinoma, Papillary ,Metastasis ,Iodine Radioisotopes ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,False Positive Reactions ,Thyroid Neoplasms ,Radiopharmaceuticals ,Epithelial cyst ,business ,Radionuclide Imaging ,Thyroid cancer ,Peritoneal Neoplasms ,Aged - Published
- 2011
35. A false positive finding on the PET of somatostatin receptor due to a chondromyxoid fibroma
- Author
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Angelina Filice, Stefano Cafarotti, Filippo Lococo, Giorgio Treglia, and Francesco Bertagna
- Subjects
Adult ,Male ,medicine.medical_specialty ,False positive finding ,Pathology ,business.industry ,Somatostatin receptor ,Chondromyxoid fibroma ,General Engineering ,Bone Neoplasms ,Ribs ,Fibroma ,medicine.disease ,Endocrinology ,Text mining ,Internal medicine ,Positron-Emission Tomography ,medicine ,Humans ,General Earth and Planetary Sciences ,Radiology, Nuclear Medicine and imaging ,False Positive Reactions ,Receptors, Somatostatin ,business ,General Environmental Science - Published
- 2014
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36. Colorectal polyps: Detection with multi-slice CT colonography
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E. Neumann, N. Lügering, Johannes Wessling, Roman Fischbach, D. Domagk, and Walter Heindel
- Subjects
Male ,medicine.medical_specialty ,False positive finding ,Supine position ,Multislice spiral ct ,Colonic Polyps ,Colonoscopy ,Colonic Diseases ,Imaging, Three-Dimensional ,Predictive Value of Tests ,Image Processing, Computer-Assisted ,medicine ,Carcinoma ,Humans ,Mass Screening ,Radiology, Nuclear Medicine and imaging ,Multislice ct ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Multi slice ct ,Stenosis ,Female ,Radiology ,Colorectal Neoplasms ,Tomography, X-Ray Computed ,business ,Intestinal Obstruction - Abstract
Purpose: To compare the performance of virtual and conventional colonoscopy for the detection of colorectal polyps using a multislice spiral CT scanner (MSCT). Materials and Methods: 48 patients (20 women, 28 men, mean age 61.5 5 years) with clinical indication for conventional colonoscopy were prospectively studied using a MSCT (Somatom Volume Zoom, Siemens, Forchheim). Examination was performed after standard oral preparation for colonoscopy and colonic distension with room air and i.v. butylscopolamin. Images were obtained in prone and supine position using a detector configuration of 4 × 1 mm, a table feed of 5 mm/rotation at 140 mAs and 120 kV. Slice thickness and reconstruction increment were 3 and 1.5 mm, respectively. CT data were assessed by two blinded radiologists on a Vitrea workstation (Vital Images, USA) using a software with multiplanar and volume-rendering capabilities. Results: 33 patients had normal findings on conventional colonoscopy. In 15 patients a total of 30 polyps and one carcinoma with stenosis were identified. MSCT-colonography identified the carcinoma and 23 polyps (77%). 3 of 3 polyps were 10 mm or more (100%), 6 of 7 were 5.1 to 9.9 mm (86%) and 14 of 20 were 5 mm or smaller (70%). There were 13 false positive findings for polyps (10 lesions < 6 mm in 5 patients) and no false positive finding of carcinoma. Conclusions: MSCT colonography allows accurate detection of polyps larger than 10 mm. Compared to published results of single-slice CT, multislice CT colonography increases the rate of detection of small colorectal polyps in particular. However, false positive results still remain a problem.
- Published
- 2001
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37. Suture granuloma showing false-positive finding on PET/CT after head and neck cancer surgery
- Author
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Yukihiro Imai, Hiroshi Yamazaki, Masahiro Kikuchi, Yuji Nakamoto, Yasushi Naito, Risa Kurihara, Keizo Fujiwara, Yosuke Tona, Shogo Shinohara, and Yuji Kanazawa
- Subjects
Male ,medicine.medical_specialty ,False positive finding ,Multimodal Imaging ,Postoperative Complications ,Suture (anatomy) ,Fluorodeoxyglucose F18 ,Biopsy ,medicine ,Humans ,False Positive Reactions ,Aged ,PET-CT ,Granuloma ,medicine.diagnostic_test ,Sutures ,business.industry ,Head and neck cancer ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Otorhinolaryngologic Surgical Procedures ,Otorhinolaryngology ,Positron emission tomography ,Head and Neck Neoplasms ,Positron-Emission Tomography ,Female ,Radiology ,Differential diagnosis ,business ,Tomography, X-Ray Computed ,Suture granuloma - Abstract
We report herein two cases of suture granuloma showing focal intense 2-deoxy-2-[18F]fluoro- d -glucose (FDG)-uptake in positron emission tomography (PET). Follow-up FDG-PET after surgical intervention for head and neck cancer revealed lesions with high FDG-uptake, which were highly suspected of being a recurrent tumor. The lesions were subjected to excisional biopsy for definitive diagnosis. Histopathological examination proved them to be suture granulomas caused by non-absorbable silk sutures. It should be emphasized that suture granulomas can show false-positive findings on FDG-PET, thus requiring differential diagnosis from recurrent tumors.
- Published
- 2010
38. A Novel Wavelet Based Algorithm for Spike and Wave Detection in Absence Epilepsy
- Author
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C.C. Liu, Steffen Rebennack, Basim M. Uthman, Panos M. Pardalos, Petros Xanthopoulos, Jicong Zhang, and Gregory L. Holmes
- Subjects
Epilepsy ,False positive finding ,Wavelet ,medicine.diagnostic_test ,Computer science ,medicine ,Spike-and-wave ,In patient ,Neurophysiology ,Electroencephalography ,medicine.disease ,Algorithm ,Continuous/uninterrupted - Abstract
Absence seizures are characterized by sudden loss of consciousness and interruption of ongoing motor activities for a brief period of time lasting few to several seconds and up to half a minute. Due to their brevity and subtle clinical manifestations absence seizures are easily missed by inexperienced observers. Accurate evaluation of their high frequency of recurrence can be a challenge even for experienced observers. We present a novel method for detecting and analyzing absence seizures acquired from electroencephalogram (EEG) recordings in patients with absence seizures. Six patients were included in this study, two seizure free, of a total recording time of 26 hours, and four experiencing over 100 seizures within 14.5 hours of total recordings. Our algorithm detected only one false positive finding in the first seizure free patients and 148 of 186 continuous uninterrupted 3Hz spike and wave discharge (SWD) epochs in the rest of the patients. Out of the total 38 missed SWD epochs 28 were
- Published
- 2010
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39. Screening von Nierenarterienstenosen
- Author
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F. Karnel, M. Baldt, Franz Kainberger, Martin Breitenseher, P. Barton, Siegfried Trattnig, and P. Hübsch
- Subjects
medicine.medical_specialty ,Kidney ,False positive finding ,medicine.diagnostic_test ,business.industry ,urologic and male genital diseases ,medicine.disease ,Renal artery stenosis ,Stenosis ,medicine.anatomical_structure ,Renal angiography ,Angiography ,medicine ,Colour doppler ,Screening method ,Radiology, Nuclear Medicine and imaging ,Radiology ,business - Abstract
The value of colour Doppler sonography in the diagnosis of renal artery stenosis has been studied retrospectively. 17 patients were examined (34 main renal arteries and 7 accessory renal arteries; ages 37 to 84 years; 7 males and 10 females). We studied 1) ability to study the main renal arteries, 2) visibility of accessory renal arteries and 3) the sensitivity and specificity of colour Doppler sonography for the diagnosis of renal artery stenosis. The results were compared with intraarterial angiography. Demonstration of the main renal arteries with colour Doppler sonography was possible in 23 of the 34 vessels. Not a single of the 7 accessory renal arteries was demonstrated by colour Doppler sonography. Of 8 angiographically demonstrated stenoses (more than 50% narrowing) 2 were missed by colour Doppler sonography. One stenosis was correctly diagnosed and 5 were incorrectly evaluated by sonography. 16 out of 18 angiographically normal main renal arteries were correctly evaluated by colour Doppler sonography but 2 showed a false positive finding. This results in a sensitivity of 17% and a specificity of 89% per kidney. Colour Doppler sonography cannot be recommended as a screening method for renal artery stenosis in view of its limited accuracy.
- Published
- 1992
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40. The double-line sign: a false positive finding on the Focused Assessment with Sonography for Trauma (FAST) examination
- Author
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Michael J. Bauman, Jason T. Nomura, Joel M. Schofer, and Paul Sierzenski
- Subjects
Adult ,Male ,medicine.medical_specialty ,False positive finding ,business.industry ,Trauma center ,Ultrasound ,Echogenicity ,Abdominal Injuries ,Wounds, Stab ,Adipose capsule of kidney ,Emergency Medicine ,medicine ,Focused assessment with sonography for trauma ,Ascitic Fluid ,Humans ,False Positive Reactions ,Hemoperitoneum ,Radiology ,medicine.symptom ,Pouch ,business ,Peritoneal Cavity ,Ultrasonography - Abstract
Background: Emergency physicians commonly perform Focused Assessment with Sonography for Trauma (FAST) examinations to evaluate for free intraperitoneal fluid. Many ultrasound findings can be misinterpreted as free fluid, resulting in false-positive FAST examinations. Objectives: To describe a previously unreported ultrasound finding that can be misinterpreted as free intraperitoneal fluid. Case Report: A 32-year-old man was stabbed in the left upper abdomen. A FAST examination was performed and a right perinephric fat pad was interpreted as showing free fluid in Morison's pouch. After transfer to a trauma center, a repeat FAST examination revealed no signs of intraperitoneal free fluid. Wound exploration showed no signs of penetration into the peritoneal cavity. Conclusions: When performing a FAST examination, a wedge-shaped hypoechoic area in Morison's pouch that is bounded on both sides by echogenic lines (the “FAST Double-Line Sign”) is likely to represent perinephric fat and may result in a false-positive FAST examination.
- Published
- 2009
41. Avid 18F-FDG uptake of pectoralis major muscle: an equivocal sequela of strenuous physical exercise
- Author
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Wfe Lau and F Fathinul
- Subjects
Muscle exercise ,medicine.medical_specialty ,False positive finding ,Radiological and Ultrasound Technology ,Metastatic melanoma ,exercise ,business.industry ,Fdg uptake ,Pectoralis major muscle ,Biomedical Engineering ,Skeletal muscle ,Physical exercise ,Sequela ,chemical and pharmacologic phenomena ,Case Report ,18F-FDG uptake ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Internal medicine ,Cardiology ,Medicine ,Radiology, Nuclear Medicine and imaging ,pectoralis major muscle ,business - Abstract
Avid functional (18)F-FDG uptake of skeletal muscle is a known false positive finding of PET-CT study especially after involuntary muscle exercise just prior to the study. We describe the case of a 50-year-old man in whom the finding of avid (18)F-FDG uptake of pectoralis major muscle was encountered during investigation of metastatic melanoma.
- Published
- 2009
42. Acoustical markers for CAD-detected pulmonary nodules in chest CT: A way to avoid suggestion and distraction of radiologist's attention?
- Author
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F. Beyer, Dag Wormanns, and Walter Heindel
- Subjects
False positive finding ,medicine.medical_specialty ,Lung ,medicine.anatomical_structure ,business.industry ,Computer-aided diagnosis ,medicine ,Chest ct ,Nodule (medicine) ,CAD ,Radiology ,medicine.symptom ,business - Abstract
Purpose: To compare the influence of visual and acoustical CAD markers on radiologists performance with regard to suggestive and distractive effects. Materials and methods: Ten radiologists analyzed 150 pictures of ches t CT slices. Every picture contained a visual CAD marker. 100 pictures showed one nodule: CAD marker marked this in 50 cases and in 50 cases a false positive finding (f.p.). The other 50 cases showed no nodule but an f.p. marker. After 3 years same images were presented to thirteen radiologists with only a sound as CAD marker. 55 of 150 images were marked, 30 true positive and 25 f.p. Sensitivity and f.p. rate were calculated for both marker ty pes. Significance between sens itivities and f.p. rates were calculated by multiple-ana lysis-of-variance (MANOVA). Results: Without CAD mean sensitivity resp. f.p. were 57.7% /.13 . In case of correct optical resp. acoustical marker sensitivity increased to 75.6% resp. 63.1%. For incorrect se t marker mean f.p. rate increased to .31 resp. .24. MANOVA showed that markers correctness highly significan tly influenced sensitivity (p
- Published
- 2009
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43. Detection and Classification of Suspicious Areas in Autofluorescence Bronchoscopy
- Author
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Maria Haritou, Panagiotis Bountris, N. Apostolou, Elisavet Passalidou, and Dimitris Koutsouris
- Subjects
False positive finding ,Pathology ,medicine.medical_specialty ,Intelligent computing ,business.industry ,Bronchial mucosa ,Medicine ,business ,Texture feature ,respiratory tract diseases ,Autofluorescence bronchoscopy - Abstract
Autofluorescence bronchoscopy (AFB) has been utilized over the past decade, proving to be a powerful tool for the detection and localization of premalignant and malignant lesions of the airways. Autofluorescence bronchoscopy is, however, characterized by low specificity and a high rate of false positive findings (FPFs). The majority of FPFs are due to inflammations, as they often fluoresce at the same wavelengths with cancer. According to several clinical trials, the percentage of the FPFs is about 30%. In this paper we present an intelligent computing system for the classification of suspicious areas of the bronchial mucosa, in order to decrease the rate of FPFs, to increase the specificity and sensitivity of AFB and enhance the overall diagnostic value of the AFB method.
- Published
- 2009
- Full Text
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44. The 'gastric fluid' sign: an unrecognized false-positive finding during focused assessment for trauma examinations
- Author
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Justin Racht and Arun Nagdev
- Subjects
Male ,medicine.medical_specialty ,False positive finding ,Diaphragm ,Physical examination ,Abdominal Injuries ,X ray computed ,medicine ,Ascitic Fluid ,Humans ,False Positive Reactions ,Intensive care medicine ,Peritoneal Cavity ,Physical Examination ,Ultrasonography ,medicine.diagnostic_test ,Gastric fluid ,business.industry ,Stomach ,nutritional and metabolic diseases ,General Medicine ,Middle Aged ,nervous system diseases ,Surgery ,Emergency Medicine ,business ,Emergency Service, Hospital ,Tomography, X-Ray Computed ,Spleen ,Sign (mathematics) ,Medical literature - Abstract
The FAST exam has become the current standard for free intraperitoneal fluid determination in most emergency departments. Knowledge of false negative and false positive findings is imperative to improve accuracy. We detail a case in which an important false positive findings previously not discussed in the medical literature was noted. The ability of the physician to recognize the "gastric fluid" sign and make the adjustments accordingly could improve the specificity of the FAST exam, preventing non-therapeutic laparotomies.
- Published
- 2007
45. Visualization of CAD results to the radiologist: influence of the marker type on radiologists's sensitivity for the detection of pulmonary nodules
- Author
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F. Beyer, Walter Heindel, Dag Wormanns, and Stefan Diederich
- Subjects
medicine.medical_specialty ,False positive finding ,business.industry ,Chest ct ,CAD ,Nodule (medicine) ,Thin walled ,Computer-aided diagnosis ,Pulmonary nodule ,Medicine ,Radiology ,medicine.symptom ,business ,Nuclear medicine ,Sensitivity (electronics) - Abstract
Purpose: The efficiency of the detection of pulmonary nodules by a radiologist with the help of CAD is influenced by the user interface of the system. Marker with a visually dominant appearance may distract the radiologist from other parts of the screen. Purpose was to analyse the influence of different CAD markers on radiologist's performance. Materials and methods: 10 radiologists analysed 150 pictures of chest CT slices. Every picture contained a CAD marker; five different types of markers were used - each respectively on 30 pictures (1: thick walled square, 2: thin walled circle, 3: small arrow, 4: pixel sized point on nodule, 5: very subtle change of colour). One hundred images contained one nodule: CAD markers marked this finding in 50 cases; in 50 cases a false positive finding was marked instead. The remaining 50 images contained no nodule but a marker of a false positive finding. The radiologists had to decide for each image if there was a nodule visible and either click on the nodule or on a button "no finding". Sensitivity and specificity were calculated for each marker type. Results: Mean sensitivity was 59%, 62%, 64%, 65% and 64% for marker 1 to 5, respectively. Specificity was 50%, 51%, 64%, 45% and 67%. In the cases with false positive findings sensitivity for detection of the unmarked nodule was 41%, 58%, 59%, 49% and 54%. New work to be presented: The study shows that the marker type influences radiologist's sensitivity and distraction from other findings. Conclusion: Of the tested markers a small arrow was most efficient for the presentation of the results to the radiologist.
- Published
- 2007
- Full Text
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46. Comparison of functional imaging in multiple myeloma patients: Indication for hybrid-imaging with PET/MRI?
- Author
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Christos Sachpekidis, Stefan Delorme, Heinz Peter Schlemmer, Jens Hillengass, Uwe Haberkorn, Jennifer Mosebach, and Antonia Dimitrakopoulou-Strauss
- Subjects
False positive finding ,Radiological and Ultrasound Technology ,business.industry ,General Medicine ,Speaker Presentation ,medicine.disease ,Bioinformatics ,Functional imaging ,Oncology ,medicine ,Diffuse infiltration ,Radiology, Nuclear Medicine and imaging ,Nuclear medicine ,business ,Multiple myeloma - Abstract
Methods 24 primary and pre-treated patients diagnosed with multiple myeloma according to the International Myeloma Working Group criteria were examined by F-FDG PET/CT and whole-body MRI including DWI (b= 0, and b= 800 s/mm). F-FDG PET/MRI was used to achieve correct matching of findings in the corresponding PET/ CT study. Suspicious lesions were defined by the imaging gold-standard of nonenhanced T1-w/T2-wMRI and low-dose CT.
- Published
- 2015
47. Potential effect of CAD systems on the detection of actionable nodules in chest CT scans during routine reporting
- Author
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Walter Heindel, Dag Wormanns, Livia Zierott, Arnauld Butzbach, and F. Beyer
- Subjects
medicine.medical_specialty ,False positive finding ,business.industry ,Potential effect ,Chest ct ,Nodule (medicine) ,CAD ,Cad system ,Radiologist 2 ,Pulmonary nodule ,Medicine ,cardiovascular diseases ,Radiology ,medicine.symptom ,business ,Nuclear medicine - Abstract
The purpose of the presented study was to determine the impact of two different CAD systems used as concur-rent reader for detection of actionable nodules (>4 mm) on the interpretation of chest CT scans during routine reporting. Fifty consecutive MDCT scans (1 mm or 1.25 mm slice thickness, 0.8 mm reconstruction increment) were se-lected from clinical routine. All cases were read by a resident and a staff radiologist, and a written report was available in the radiology information system (RIS). The RIS report mentioned at least one actionable pulmonary nodule in 18 cases (50%) and did not report any pulmonary nodule in the remaining 32 cases. Two different recent CAD systems were independently applied to the 50 CT scans as concurrent reader with two radiologists: Siemens LungCare NEV and MEDIAN CAD-Lung. Two radiologists independently reviewed the CAD results and determined if a CAD result was a true positive or a false positive finding. Patients were classified into two groups: in group A if at least one actionable nodule was detected and in group B if no actionable nodules were found. The effect of CAD on routine reporting was simulated as set union of the findings of routine reporting and CAD thus applying CAD as concurrent reader. According to the RIS report group A (patients with at least one actionable nodule) contained 18 cases (36% of all 50 cases), and group B contained 32 cases. Application of a CAD system as concurrent reader resulted in detec-tion of additional CT scans with actionable nodules and reclassification into group A in 16 resp. 18 cases (radi-ologist 1 resp. radiologist 2) with Siemens NEV and in 19 resp. 18 cases with MEDIAN CAD-Lung. In seven cases MEDIAN CAD-Lung and in four cases Siemens NEV reclassified a case into group A while the other CAD system missed the relevant finding. Sensitivity on a nodule (>4 mm) base was .45 for Siemens NEV and .55 for MEDIAN CAD-Lung; the difference was not yet significant (p=.077). In our study use of CAD as second reader in routine reporting doubled the percentage of patients with actionable nodules larger than 4 mm.
- Published
- 2006
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48. Fluid-filled bowel mimicking hemoperitoneum: a false-positive finding during sonographic evaluation for trauma
- Author
-
John L. Kendall and Joseph P Ramos
- Subjects
Adult ,medicine.medical_specialty ,False positive finding ,Computed tomography ,Abdominal Injuries ,Wounds, Nonpenetrating ,Diagnosis, Differential ,Intensive care ,medicine ,Ascitic Fluid ,Humans ,False Positive Reactions ,Hemoperitoneum ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Multiple Trauma ,Ultrasound ,Emergency department ,Intestines ,Treatment Outcome ,Emergency Medicine ,Female ,Radiology ,medicine.symptom ,Pouch ,business ,Motor vehicle crash - Abstract
This case report describes a patient who presented to the Emergency Department (ED) after a high-speed motor vehicle crash (MVC), whose initial ultrasound examination was interpreted as being positive for fluid in Morison’s pouch. Subsequent ultrasound examinations and computed tomography scans further delineated this finding to be fluid-filled bowel juxtaposed between the liver and right kidney. With greater implementation of ED ultrasound, it is important to identify entities that cause false-positive and false-negative examinations.
- Published
- 2003
49. Retention of iodine-131 in respiratory tract in a patient with papillary thyroid carcinoma after radionuclide therapy: a rare false-positive finding
- Author
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S. Özer, Oskar Kienast, Georg Dobrozemsky, Robert Dudczak, Amir Kurtaran, and M. Hofmann
- Subjects
Pathology ,medicine.medical_specialty ,False positive finding ,Lung Neoplasms ,Endocrinology, Diabetes and Metabolism ,Respiratory System ,chemistry.chemical_element ,Iodine ,Thyroid carcinoma ,Iodine Radioisotopes ,Endocrinology ,Medicine ,Humans ,False Positive Reactions ,Thyroid Neoplasms ,Radionuclide Imaging ,business.industry ,Middle Aged ,Carcinoma, Papillary ,medicine.anatomical_structure ,chemistry ,Radionuclide therapy ,Female ,Radiology ,business ,Respiratory tract - Published
- 2003
50. Report of two cases of fluorodeoxyglucose positron emission tomography/computed tomography appearance of hibernoma: A rare benign tumor
- Author
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Archi Agrawal, Venkatesh Rangarajan, Seema Kembhavi, Sneha Shah, and Nilendu Purandare
- Subjects
False positive finding ,medicine.medical_specialty ,hibernoma ,Case Report ,Computed tomography ,Benign tumor ,fluorodeoxyglucose positron emission tomography/computed tomography ,Fluorodeoxyglucose positron emission tomography ,Brown adipose tissue ,medicine ,Radiology, Nuclear Medicine and imaging ,Positron Emission Tomography-Computed Tomography ,Fluorodeoxyglucose ,medicine.diagnostic_test ,business.industry ,brown fat ,nutritional and metabolic diseases ,medicine.disease ,nervous system diseases ,medicine.anatomical_structure ,Benign ,Radiology ,Nuclear medicine ,business ,Hibernoma ,medicine.drug - Abstract
False-positive findings are commonly seen in positron emission tomography computed tomography imaging. One of the most common false positive finding is uptake of fluorodeoxyglucose in brown adipose tissue. Herein, we report two cases with incidentally detected hibernomas-a brown fat containing tumor with metabolic activity.
- Published
- 2014
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