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13 results on '"F. Tanguy"'

3. Insuffisance thyréotrope gravidique et maladie de Basedow

Author

Daniel Glinoer, Ph. Caron, S. Hamdi, and F. Tanguy

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism, General Medicine
Abstract

Introduction La survenue d’une grossesse chez les patientes presentant une maladie de Basedow expose aux complications maternelles de la thyreotoxicose et a une hyperthyroidie fœtale liees aux anticorps anti-recepteur de la TSH (Ac anti-RTSH) stimulants. Une patiente avec une maladie de Basedow presente une insuffisance thyreotrope au cours d’une grossesse. Patiente Mme L, âgee de 26 ans, presente une maladie de Basedow recidivante traitee par antithyroidiens de synthese. Alors qu’elle debute sa 2e grossesse, la palpation du cou retrouve un volumineux goitre vasculaire. Le thiamazole est arrete et la surveillance hormonale note au terme du 1er trimestre l’apparition d’une insuffisance thyreotrope : TSH = 1 mU/L (0,27-4,3), T4l = 0,67 ng/dl (0,81-1,32), T3l = 2,37 ng/l (2,47-4,1), les Ac anti-RTSH sont positifs (3,5 UI/L), stimulants (+ 285 %) et la concentration de betahCG est a 153 656 UI/L. Un traitement substitutif par levothyroxine restaure l’euthyroidie, les Ac anti-RTSH se negativent au 2e trimestre de gestation. La patiente donne naissance a d’une fille (3,2 kg) euthyroidienne sans goitre. En post-partum, le bilan hypophysaire est normal (retour de couche spontane, respect des fonctions hypophysaires, pas d’anomalie a l’IRM). Le traitement par levothyroxine est progressivement arrete et la patiente presente une nouvelle recidive de sa maladie de Basedow a 8 mois de l’accouchement. Conclusion Nous rapportons la premiere observation d’insuffisance thyreotrope transitoire au cours d’une grossesse chez une patiente suivie pour une maladie de Basedow, faisant discuter le role physiopathologique des Ac anti-RTSH ou de certaines formes moleculaires d’hCG.

Published
2020
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4. Focal plane for the next generation of earth observation instruments

Author

Francis Descours, Pascal Pranyies, Isabelle Toubhans, F. Tanguy, and B. Badoil

Subjects
Physics, chemistry.chemical_compound, Earth observation, Cardinal point, Optics, chemistry, business.industry, Multispectral image, Detector, Silicon carbide, Pleiades, business, Constellation
Abstract

Sodern is the French focal plane provider for Earth Observation (EO) satellites. Since the 1980’s, Sodern has played an active role first in the SPOT program. Within the two-spacecraft constellation Pleiades 1A/1B over the next years, Sodern introduced advanced technologies as Silicon Carbide (SiC) focal plane structure and multispectral strip filters dedicated to multiple-lines detectors.

Published
2017
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5. Silicon carbide metallization

Author

F. Lescoat, F. Tanguy, and P. Durand

Subjects
chemistry.chemical_compound, Materials science, chemistry, business.industry, Silicon carbide, Electronic engineering, Optoelectronics, Electronics, business
Abstract

A study has been done to assess the feasibility of metallization of Silicon Carbide (SiC) in order to simplify design and mounting of one or more ground reference rail needed to provide an electrical reference for electronics mounted on an SiC structure.

Published
2016
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6. Operando discrimination of fast and slow active grains within a cycling electrode for lithium battery

Author

Joël Gaubicher, F. Tanguy, Dominique Guyomard, Institut des Matériaux Jean Rouxel (IMN), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Ecole Polytechnique de l'Université de Nantes (EPUN), and Université de Nantes (UN)-Université de Nantes (UN)

Subjects
Working electrode, Chemistry, 020209 energy, Kinetics, Analytical chemistry, 02 engineering and technology, Electrolyte, 021001 nanoscience & nanotechnology, Electrochemistry, Decomposition, Lithium battery, lcsh:Chemistry, chemistry.chemical_compound, lcsh:Industrial electrochemistry, lcsh:QD1-999, Ternary compound, Electrode, 0202 electrical engineering, electronic engineering, information engineering, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], 0210 nano-technology, lcsh:TP250-261
Abstract

The impact of the formation of an electrolyte based decomposition layer on the distribution of the active grain kinetics has been investigated operando within a cycling electrode for lithium battery. It is demonstrated, from fitting procedure of the electrochemical responses and from operando XRD experiments, that as the passive film forms, slow reacting grains appear within the working electrode and operate simultaneously with faster grains. Slow grains are macroscopically distributed, presumably at the electrolyte side of the electrode. Discrimination of the electrochemical response pertaining to each type of grains allows rationalizing their contribution to the capacity fading dynamics. Keywords: Slow and fast grains, Electrochemical peak fitting, Operando XRD, Capacity fading, Electrolyte decomposition, Li battery

Published
2010
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7. Intérêt de l'évaluation clinique en hôpital de jour pour jeunes enfants

Author

F. Tanguy

Subjects
Psychiatry and Mental health, medicine.medical_specialty, Health services, Medical screening, Public health, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, Salud mental, medicine, Day hospital, Psychology, Humanities
Abstract

Resume L'etude longitudinale de trois enfants pris en charge en hopital de jour entre quatre ans et sept ans proposee ici cherche a montrer l'importante evolution, mise en evidence par des evaluations psychologiques, tant intellectuelle, cognitive que comportementale et affective qu'un suivi intensif, individualise et long peut permettre si l'alliance therapeutique avec la famille est de qualite. Nous insistons aussi sur l'importance d'un depistage precoce et d'un accompagnement des familles vers l'acceptation de ce type d'orientation. Elle permet egalement une discussion diagnostique entre troubles autistiques et troubles de l'attachement, la formulation d'hypotheses pronostiques et une reflexion sur les dispositifs therapeutiques.

Published
2005
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9. AGATA-Advanced GAmma Tracking Array

Author

A. Colombo, Y. Mariette, A. Johnson, W. Korten, A. Brondi, T. Faul, J. Robin, R. Depalo, M. Slee, J. Gre¸bosz, H. C. Boston, H. Harroch, B. Rossé, M. Filliger, M. Gulmini, A. Korichi, S. Brambilla, J.R. Cresswell, C. Parisel, P. Edelbruck, F. Ameil, F. Camera, C. Oziol, Matthew Richard Dimmock, G. Salvato, F. Morbiducci, J. Ropert, M. Borsato, E. Legay, Marco Bellato, C. Santos, Gheorghe Pascovici, L. Charles, J. Pancin, G. Casati, P. G. Bizzeti, T. Stanios, S. Lhenoret, Diego Barrientos, P.M. Jones, Andreas Görgen, V. Chambert, S. Aydin, K. Hauschild, B. Hervieu, R. Nicolini, J. Simpson, H. J. Wollersheim, L. Lavergne, Pär-Anders Söderström, G. S. Simpson, G. Jaworski, F. Filmer, R. Griffiths, P.S. Morrall, M. Petcu, G. Lo Bianco, D. Linget, A. Givechev, D. C. Oxley, M. Kogimtzis, F. Salomon, J. Jolie, D. Wells, S. Moon, C. Aufranc, A. Corsi, T. Descombes, N. Goel, J. Thornhill, N. Warr, Serkan Akkoyun, B. Birkenbach, F. Dorangeville, Joël Chavas, P. Medina, Roberto Isocrate, C. Weber, E. Merchan, Bo Cederwall, I. Kojouharov, Enrique Sanchis, A. Lopez-Martens, Oliver Wieland, F. Le Blanc, D. Seddon, S. C. Letts, D. Bazzacco, J. Leske, B. Bruyneel, Alberto Pullia, L. Nelson, G. La Rana, B. Travers, I. Burrows, G. Maron, S. Coelli, J. J. Valiente-Dobón, F. Saillant, Piotr Bednarczyk, V.L. Ngo, J. Mierzejewski, Norbert Pietralla, R.S. Kempley, N. Kurz, M. Rebeschini, S. Fantinel, D. L. Balabanski, A. J. Boston, F. Tomasi, R. Berthier, M. D. Salsac, B. Dulny, C. Stahl, N. Dosme, C. Fanin, R. Baumann, S. Pietri, A. Astier, M. Nicoletto, J. van der Marel, A. Bracco, Björn Jonson, D. Mengoni, D. Bloor, Luna Pellegri, F. Lefebvre, D. Pugnére, J. Egea, S. Cabaret, D. Curien, M. Reese, C. Commeaux, Dirk Rudolph, A. Giannatiempo, F. Recchia, L. Ramina, A. Lermitage, C. A. Ur, R. M. Lieder, I.P. Brawn, R. Menegazzo, R. Raine, Krasimir Mitev, D. R. Napoli, G. Suliman, M. Kebbiri, Y. Drouen, Susan Rigby, W. Me¸czyński, R. Wadsworth, F. Didierjean, P. Desesquelles, Ch. Veyssiere, S. Leoni, Vicente González, P. Gros, Y. Le Noa, M. Castoldi, O. Möller, R. Orlandi, Thomas Beck, M. Şenyiğit, A. Jungclaus, L. Gibelin, Mohammed Kaci, Zs. Podolyák, J. Gerl, S. Erturk, W. Gast, B. Melon, V. Mendéz, R. Peghin, P. Molini, M. N. Erduran, D. Conventi, Pankaj S. Joshi, E. Clément, F.A. Beck, A. Austin, A. Cortesi, J. Palin, P. Cocconi, L. J. Harkness, F. C. L. Crespi, Dirk Weisshaar, P. Sona, A. Czermak, D. Lersch, N. Blasi, Anton Khaplanov, O. Stezowski, B. Rubio, R. Venturelli, M.-H. Sigward, E. Viscione, José Salt, C. S. Özben, Giancarlo Ripamonti, P. Spolaore, Johan Nyberg, S. M. Lenzi, L. Legeard, N. Redon, C. Rossi Alvarez, C. He, R. Chapman, P. Le Pouhalec, C. Diarra, Herbert Hess, T. Engert, A. Kaşkaş, Stanislav Tashenov, S. Klupp, C. Michelagnoli, Elif Ince, A. Algora, J. F. Smith, M. Ozille, Alessandro Zucchiatti, Angelo Geraci, A. Olariu, M. Labiche, N. Karkour, Stefano Riboldi, P. Bourgault, C. M. Petrache, M. Palacz, M. El Chambit, J.-L. Cercus, M. Zie¸bliński, Alex Wiens, R. Beunard, X. Lafay, T. Habermann, M. Karolak, L. Costa, Y. Aubert, Begoña Quintana, A P Robinson, V. F. E. Pucknell, D. Rosso, A. Capsoni, Emanuele Vardaci, L. Mihailescu, M. Tripon, E. Farnea, Ch. Theisen, Enrico Calore, G. Duchêne, N. V. Zamfir, X. Grave, S. Lunardi, I.H. Lazarus, José Blasco, D. Montanari, J.A. Sampson, P. H. Regan, N. Marginean, M. Pignanelli, L. Arnold, G. Benzoni, R. Krücken, G. de Angelis, D.P. Scraggs, I. Piqueras, D. M. Cullen, A. Obertelli, A. Bürger, D. Bortolato, G. Rainovski, A.R. Mather, P. Reiter, C. Unsworth, G. Baulieu, P. J. Coleman-Smith, C. Boiano, M. Richer, Sébastien Perrier, Agnese Giaz, Reynold J. Cooper, V. Vandone, S. Tanguy, C. Domingo-Pardo, A. Bouty, A. N. Grint, A. Maj, A. Gottardo, L. Berti, E. Pachoud, R. Marginean, E. A. Stefanova, A. Triossi, M. Nespolo, D. Bucurescu, R. Moro, H.T.M. Ha, D. S. Judson, J. L. Tain, A. Perego, Francesco Lelli, P. Detistov, B.Y. Ky, J. Ljungvall, B. Sowicki, M. Schlarb, F. Azaiez, P. Pariset, Ertan Şahin, R. Gernhäuser, M. Turcato, John Paul Strachan, B. Million, A. Atac, F. Carrio, D. Delbourg, F. Veronese, Th. Kröll, B. Cahan, A. Hernandez-Prieto, M. A. Bentley, K.M.M. Tun-Lanoë, B. Alikhani, P. Boutachkov, S. Leboutelier, Maria Doncel, A. M. Bizzeti-Sona, R. Touzery, A. Nannini, A. Lotode, P. J. Nolan, G. Rampazzo, F. Zocca, H. Schaffner, J. Eberth, A. Gadea, N. Toniolo, T. Hüyük, Q.T. Doan, P. Petkov, S. Broussard, S. Badoer, M. Rigato, Philip M Walker, J. Pouthas, Ch. Finck, L. Milechina, M. Norman, E. Pierre, J. Roccaz, S.J. Colosimo, Lázaro Guevara, Glyn Wittwer, Millan, Vicente Gonzalez -- 0000-0001-6014-2586, Rainovski, Georgi -- 0000-0002-1729-0249, Jaworski, Grzegorz -- 0000-0003-2241-0329, KORTEN, Wolfram -- 0000-0002-3940-0816, Domingo-Pardo, Cesar -- 0000-0002-2915-5466, Triossi, Andrea -- 0000-0001-5140-9154, Huyuk, Tayfun -- 0000-0003-0597-9767, Ince, Elif -- 0000-0003-4821-5441, Algora, Alejandro -- 0000-0002-5199-1794, Calore, Enrico -- 0000-0002-2301-3838, Rubio, Berta -- 0000-0002-9149-4151, THEISEN, Christophe -- 0000-0002-8509-1022, Rudolph, Dirk -- 0000-0003-1199-3055, Gadea, Andres -- 0000-0002-4233-1970, santos, cayetano -- 0000-0003-0727-1914, nannini, adriana -- 0000-0003-0659-7648, Depalo, Rosanna -- 0000-0003-3943-7982, Suliman, gabriel -- 0000-0001-8475-1992, Blasco, Jose-Maria -- 0000-0002-7663-9092, Petrache, Costel -- 0000-0001-8419-1390, Pietralla, Norbert -- 0000-0002-4797-3032, Cederwall, Bo -- 0000-0003-1771-2656, Zucchiatti, Alessandro -- 0000-0002-3647-596X, Mendez Munoz, Victor -- 0000-0002-9044-1189, Kruecken, Reiner -- 0000-0002-2755-8042, Napoli, Daniel Ricardo -- 0000-0002-8154-6958, Tain, Jose L. -- 0000-0002-3263-6965, SANCHIS, ENRIQUE -- 0000-0002-9689-9131, Zieblinski, Miroslaw -- 0000-0002-8693-7317, Hauschild, Karl -- 0000-0003-2862-2445, Montanari, Daniele -- 0000-0002-1980-7686, senyigit, menekse -- 0000-0002-2408-4419, La Rana, Giovanni -- 0000-0003-2814-4113, Menegazzo, Roberto -- 0000-0002-3060-5276, Soderstrom, Par-Anders -- 0000-0002-9504-2814, Unsworth, Carl -- 0000-0002-4100-7466, Camera, Franco -- 0000-0003-1731-4834, Gorgen, Andreas -- 0000-0003-1916-9941, Hernandez Prieto, Alvaro -- 0000-0002-0340-0240, Recchia, Francesco -- 0000-0002-8428-0112, de France, Gilles -- 0000-0002-7439-1759, GOTTARDO, Andrea -- 0000-0002-0390-5767, Perrier, Sebastien -- 0000-0001-5055-9046, Sowicki, Bogdan -- 0000-0002-7208-0690, Robinson, Andrew -- 0000-0002-2510-1321, Sahin, Eda -- 0000-0003-0683-5140, Pullia, Alberto -- 0000-0002-6393-747X, Lelli, Francesco -- 0000-0003-1900-9171, Clement, Emmanuel -- 0000-0003-1887-717X, benzoni, giovanna -- 0000-0002-7938-0338, Jonson, Bjorn -- 0000-0002-9697-9115, Bednarczyk, Piotr -- 0000-0002-5699-5292, Jones, Pete -- 0000-0001-7480-6603, Nicoletto, Marino -- 0000-0001-9301-0782, Ripamonti, Giancarlo -- 0000-0002-9406-021X, Bentley, Michael -- 0000-0001-8401-3455, Pellegri, Luna -- 0000-0002-3227-3332, Barrientos, Diego -- 0000-0001-9693-2942, GIAZ, Agnese -- 0000-0002-2550-450X, [Boston, A. J. -- Boston, H. C. -- Colosimo, S. -- Cooper, R. J. -- Cresswell, J. R. -- Dimmock, M. R. -- Filmer, F. -- Grint, A. N. -- Harkness, L. J. -- Judson, D. S. -- Mather, A. R. -- Moon, S. -- Nelson, L. -- Nolan, P. J. -- Norman, M. -- Oxley, D. C. -- Rigby, S. -- Sampson, J. -- Scraggs, D. P. -- Seddon, D. -- Slee, M. -- Stanios, T. -- Thornhill, J. -- Unsworth, C. -- Wells, D.] Univ Liverpool, Oliver Lodge Lab, Liverpool L69 7ZE, Merseyside, England -- [Akkoyun, S. -- Atac, A. -- Kaskas, A. -- Senyigit, M.] Ankara Univ, Fac Sci, Dept Phys, TR-06100 Ankara, Turkey -- [Algora, A. -- Barrientos, D. -- Domingo-Pardo, C. -- Egea, J. -- Gadea, A. -- Hueyuek, T. -- Kaci, M. -- Mendez, V. -- Rubio, B. -- Salt, J. -- Tain, J. L.] Univ Valencia, CSIC, IFIC, E-46980 Paterna, Spain -- [Alikhani, B. -- Boutachkov, P. -- Givechev, A. -- Goel, N. -- Leske, J. -- Merchan, E. -- Moeller, O. -- Pietralla, N. -- Reese, M. -- Stahl, C.] Tech Univ Darmstadt, IKP, D-64289 Darmstadt, Germany -- [Ameil, F. -- Beck, T. -- Boutachkov, P. -- Domingo-Pardo, C. -- Engert, T. -- Gerl, J. -- Goel, N. -- Habermann, T. -- Kojouharov, I. -- Kurz, N. -- Merchan, E. -- Pietri, S. -- Schaffner, H. -- Tashenov, S. -- Wollersheim, H. J.] GSI Helmholtzzentrum Schwerionenforsch GmbH, D-64291 Darmstadt, Germany -- [de Angelis, G. -- Badoer, S. -- Berti, L. -- Calore, E. -- Cocconi, P. -- Conventi, D. -- Costa, L. -- Fantinel, S. -- Gadea, A. -- Gottardo, A. -- Gulmini, M. -- He, C. -- Ince, E. -- Kroell, Th. -- Lelli, F. -- Maron, G. -- Molini, P. -- Napoli, D. R. -- Rigato, M. -- Rosso, D. -- Sahin, E. -- Spolaore, P. -- Toniolo, N. -- Valiente-Dobon, J. J.] Ist Nazl Fis Nucl, Lab Nazl Legnaro, IT-35020 Padua, Italy -- [Arnold, L. -- Baumann, R. -- Beck, F. A. -- El Chambit, M. -- Charles, L. -- Curien, D. -- Didierjean, F. -- Duchene, G. -- Faul, T. -- Filliger, M. -- Finck, Ch. -- Medina, P. -- Pachoud, E. -- Parisel, C. -- Piqueras, I. -- Richer, M. -- Robin, J. -- Santos, C. -- Sigward, M. -H. -- Weber, C.] Univ Strasbourg, IPHC, F-67037 Strasbourg, France -- [Arnold, L. -- Baumann, R. -- Beck, F. A. -- El Chambit, M. -- Charles, L. -- Curien, D. -- Didierjean, F. -- Duchene, G. -- Faul, T. -- Filliger, M. -- Finck, Ch. -- Medina, P. -- Pachoud, E. -- Parisel, C. -- Piqueras, I. -- Richer, M. -- Robin, J. -- Santos, C. -- Sigward, M. -H. -- Weber, C.] CNRS, UMR 7178, F-67037 Strasbourg, France -- [Astier, A. -- Cabaret, S. -- Desesquelles, P. -- Dosme, N. -- Gibelin, L. -- Ha, H. T. M. -- Hauschild, K. -- Karkour, N. -- Korichi, A. -- Lafay, X. -- Leboutelier, S. -- Legay, E. -- Lhenoret, S. -- Linget, D. -- Ljungvall, J. -- Lopez-Martens, A. -- Morbiducci, F. -- Ngo, V. L. -- Pariset, P. -- Perrier, S. -- Pierre, E. -- Roccaz, J. -- Travers, B.] Univ Paris 11, CNRS, IN2P3, CSNSM, F-91405 Orsay, France -- [Atac, A. -- Nyberg, J. -- Soderstrom, P. -A.] Uppsala Univ, Dept Phys & Astron, Uppsala, Sweden -- [Atac, A. -- Cederwall, B. -- Johnson, A. -- Khaplanov, A. -- van der Marel, J. -- Milechina, L. -- Tashenov, S.] Royal Inst Technol, SE-10691 Stockholm, Sweden -- [Aubert, Y. -- Azaiez, F. -- Le Blanc, F. -- Cercus, J. -L. -- Chambert, V. -- Commeaux, C. -- Delbourg, D. -- Diarra, C. -- Dorangeville, F. -- Edelbruck, P. -- Grave, X. -- Guevara, L. -- Harroch, H. -- Ky, B. Y. -- Lavergne, L. -- Lefebvre, F. -- Lermitage, A. -- Olariu, A. -- Oziol, C. -- Petrache, C. -- Pouthas, J. -- Salomon, F. -- Tanguy, S. -- Tun-Lanoe, K. M. M.] Univ Paris 11, CNRS, IN2P3, IPNO, F-91406 Orsay, France -- [Aufranc, C. -- Baulieu, G. -- Doan, Q. T. -- Pugnere, D. -- Redon, N. -- Rosse, B. -- Stezowski, O.] Univ Lyon 1, CNRS, IN2P3, Inst Phys Nucl Lyon, F-69622 Villeurbanne, France -- [Austin, A. -- Burrows, I. -- Coleman-Smith, P. J. -- Griffiths, R. -- Kogimtzis, M. -- Labiche, M. -- Lazarus, I. H. -- Letts, S. C. -- Morrall, P. S. -- Palin, J. -- Pucknell, V. F. E. -- Simpson, J. -- Strachan, J.] STFC Daresbury Lab, Warrington WA4 4AD, Cheshire, England -- [Aydin, S. -- Bazzacco, D. -- Bellato, M. -- Bortolato, D. -- Chavas, J. -- Colombo, A. -- Fanin, C. -- Farnea, E. -- Isocrate, R. -- Kroell, Th. -- Lenzi, S. M. -- Lunardi, S. -- Marginean, R. -- Menegazzo, R. -- Mengoni, D. -- Michelagnoli, C. -- Nespolo, M. -- Nicoletto, M. -- Peghin, R. -- Ramina, L. -- Rampazzo, G. -- Rebeschini, M. -- Recchia, F. -- Rossi Alvarez, C. -- Salvato, G. -- Triossi, A. -- Turcato, M. -- Ur, C. A. -- Venturelli, R. -- Veronese, F.] Ist Nazl Fis Nucl, Sez Padova, IT-35131 Padua, Italy -- [Balabanski, D. L. -- Detistov, P. -- Petkov, P. -- Stefanova, E.] Bulgarian Acad Sci, Inst Nucl Res & Nucl Energy, Sofia, Bulgaria -- [Bednarczyk, P. -- Czermak, A. -- Dulny, B. -- Grebosz, J. -- Maj, A. -- Meczynski, W. -- Sowicki, B. -- Zieblinski, M.] Polish Acad Sci, Henryk Niewodniczanski Inst Nucl Phys, PL-31342 Krakow, Poland -- [Bentley, M. A. -- Bloor, D. -- Joshi, P. -- Wadsworth, R.] Univ York, Dept Phys, York YO10 5DD, N Yorkshire, England -- [Benzoni, G. -- Blasi, N. -- Boiano, C. -- Bracco, A. -- Brambilla, S. -- Camera, F. -- Capsoni, A. -- Casati, G. -- Coelli, S. -- Corsi, A. -- Cortesi, A. -- Crespi, F. C. L. -- Geraci, A. -- Giaz, A. -- Leoni, S. -- Million, B. -- Montanari, D. -- Nicolini, R. -- Pellegri, L. -- Pignanelli, M. -- Pullia, A. -- Riboldi, S. -- Ripamonti, G. -- Tomasi, F. -- Vandone, V. -- Viscione, E. -- Wieland, O. -- Zocca, F.] Ist Nazl Fis Nucl, Sez Milano, IT-20133 Milan, Italy -- [Berthier, R. -- Bouty, A. -- Broussard, S. -- Buerger, A. -- Drouen, Y. -- Gros, P. -- Goergen, A. -- Hervieu, B. -- Karolak, M. -- Kebbiri, M. -- Korten, W. -- Ljungvall, J. -- Lotode, A. -- Mariette, Y. -- Le Noa, Y. -- Obertelli, A. -- Le Pouhalec, P. -- Salsac, M. -D. -- Theisen, Ch. -- Touzery, R. -- Veyssiere, Ch.] CEA, Ctr Saclay, IRFU, F-91191 Gif Sur Yvette, France -- [Beunard, R. -- Bourgault, P. -- Cahan, B. -- Clement, E. -- de France, G. -- Legeard, L. -- Ozille, M. -- Pancin, J. -- Raine, R. -- Ropert, J. -A. -- Saillant, F. -- Tripon, M. -- Wittwer, G.] CEA DSM CNRS IN2P3, GANIL, F-14076 Caen, France -- [Birkenbach, B. -- Bruyneel, B. -- Eberth, J. -- Hess, H. -- Jolie, J. -- Lersch, D. -- Pascovici, G. -- Reiter, P. -- Warr, N. -- Weisshaar, D. -- Wiens, A.] Univ Cologne, IKP, D-50937 Cologne, Germany -- [Bizzeti, P. G. -- Bizzeti-Sona, A. M. -- Giannatiempo, A. -- Melon, B. -- Perego, A. -- Sona, P.] Univ Florence, Dipartimento Fis & Astron, IT-50019 Florence, Italy -- [Bizzeti, P. G. -- Bizzeti-Sona, A. M. -- Giannatiempo, A. -- Melon, B. -- Nannini, A. -- Perego, A. -- Sona, P.] Ist Nazl Fis Nucl, Sez Firenze, IT-50019 Florence, Italy -- [Blasco, J. M. -- Carrio, F. -- Egea, J. -- Gonzalez, V. -- Sanchis, E.] Univ Valencia, Dept Elect Engn, E-46100 Burjassot, Valencia, Spain -- [Borsato, M. -- Bortolato, D. -- Lenzi, S. M. -- Lunardi, S. -- Marginean, R. -- Mengoni, D. -- Michelagnoli, C. -- Nespolo, M. -- Recchia, F. -- Salvato, G. -- Triossi, A. -- Venturelli, R.] Univ Padua, Dipartimento Fis, IT-35131 Padua, Italy -- [Bracco, A. -- Camera, F. -- Corsi, A. -- Crespi, F. C. L. -- Giaz, A. -- Leoni, S. -- Montanari, D. -- Nicolini, R. -- Pellegri, L. -- Pignanelli, M. -- Pullia, A. -- Riboldi, S. -- Vandone, V.] Univ Milan, Dipartimento Fis, IT-20133 Milan, Italy -- [Brawn, I. P.] STFC Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England -- [Brondi, A. -- Moro, R. -- La Rana, G. -- Vardaci, E.] Univ Naples Federico II, Dipartimento Fis, IT-80126 Naples, Italy -- [Brondi, A. -- Moro, R. -- La Rana, G. -- Vardaci, E.] Ist Nazl Fis Nucl, Sez Napoli, IT-80126 Naples, Italy -- [Bucurescu, D. -- Marginean, N. -- Marginean, R. -- Petcu, M. -- Ur, C. A.] Natl Inst Phys & Nucl Engn, Bucharest, Romania -- [Buerger, A. -- Suliman, G. -- Zamfir, N. V.] Univ Bonn, Helmholtz Inst Strahlen & Kernphys, D-53115 Bonn, Germany -- [Buerger, A.] Univ Oslo, Dept Phys, N-0316 Oslo, Norway -- [Casati, G. -- Geraci, A. -- Ripamonti, G.] Politecn Milan, Dipartimento Elettron & Informaz, IT-20133 Milan, Italy -- [Castoldi, M. -- Zucchiatti, A.] Ist Nazl Fis Nucl, Sez Genova, IT-16146 Genoa, Italy -- [Chapman, R. -- Mengoni, D. -- Orlandi, R. -- Smith, J. F.] Univ W Scotland, Sch Engn, Paisley PA1 2BE, Renfrew, Scotland -- [Cullen, D. M. -- Robinson, A. P.] Univ Manchester, Sch Phys & Astron, Schuster Lab, Manchester M13 9PL, Lancs, England -- [Depalo, R.] Univ Padua, Dipartimento Astron, IT-35131 Padua, Italy -- [Descombes, T. -- Simpson, G.] Univ Grenoble 1, CNRS, IN2P3, LPSC,INP Grenoble, F-38026 Grenoble, France -- [Doncel, M. -- Hernandez-Prieto, A. -- Quintana, B.] Univ Salamanca, Dept Fis Fundamental, E-37008 Salamanca, Spain -- [Erduran, M. N. -- Ince, E.] Istanbul Univ, Istanbul, Turkey -- [Erturk, S.] Nigde Univ, Fac Sci, Dept Phys, TR-51200 Nigde, Turkey -- [Gast, W. -- Lieder, R. M. -- Mihailescu, L.] Forschungszentrum Julich, Inst Kernphys, D-52425 Julich, Germany -- [Gernhaeuser, R. -- Klupp, S. -- Kruecken, R. -- Schlarb, M.] Tech Univ Munich, Phys Dept E12, D-85748 Garching, Germany -- [Jaworski, G.] Warsaw Univ Technol, Fac Phys, PL-00662 Warsaw, Poland -- [Jaworski, G. -- Mierzejewski, J. -- Palacz, M.] Univ Warsaw, Heavy Ion Lab, PL-02093 Warsaw, Poland -- [Jones, P.] Univ Jyvaskyla, Dept Phys, FI-40014 Jyvaskyla, Finland -- [Jonson, B.] Chalmers, S-41296 Gothenburg, Sweden -- [Jungclaus, A. -- Orlandi, R.] CSIC, Inst Estruct Mat, E-28006 Madrid, Spain -- [Kempley, R. S. -- Podolyak, Z. -- Regan, P. H. -- Walker, P. M.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England -- [Mitev, K. -- Rainovski, G.] Sofia Univ St Kliment Ohridski, Fac Phys, Sofia, Bulgaria -- [Ozben, C.] Istanbul Tech Univ, TR-80626 Istanbul, Turkey -- [Rudolph, D.] Lund Univ, Dept Phys, SE-22100 Lund, Sweden, Research Group: Information Management, CSNSM SNO, Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), informatique, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, CSNSM MECA, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), CSNSM INFOR, CSNSM ELEC, Matière Nucléaire, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), AGATA, Akkoyun, S., Algora, A., Alikhani, B., Ameil, F., De Angelis, G, Arnold, L., Astier, A., Ataç, A., Aubert, Y., Aufranc, C., Austin, A., Aydin, S., Azaiez, F., Badoer, S., Balabanski, D. L., Barrientos, D., Baulieu G., L, Baumann, R., Bazzacco, D., Beck, F. A., Beck, T., Bednarczyk, P., Bellato, M., Bentley, M. A., Benzoni, G., Berthier, R., Berti, L., Beunard, R., Lo Bianco, G., Birkenbach, B., Bizzeti, P. G., Bizzeti Sona, A. M., Le Blanc, F., Blasco, J. M., Blasi, N., Bloor, D., Boiano, C., Borsato, M., Bortolato, D., Boston, A. J., Boston, H. C., Bourgault, P., Boutachkov, P., Bouty, A., Bracco, A., Brambilla, S., Brawn, I. P., Brondi, Augusto, Broussard, S., Bruyneel, B., Bucurescu, D., Burrows, I., Bürger, A., Cabaret, S., Cahan, B., Calore, E., Camera, F., Capsoni, A., Carrió, F., Casati, G., Castoldi, M., Cederwall, B., Cercus J., L, Chambert, V., El Chambit, M., Chapman, R., Charles, L., Chavas, J., Clément, E., Cocconi, P., Coelli, S., Coleman Smith, P. J., Colombo, A., Colosimo, S., Commeaux, C., Conventi, D., Cooper, R. J., Corsi, A., Cortesi, A., Costa, L., Crespi, F. C. L., Cresswell, J. R., Cullen, D. M., Curien, D., Czermak, A., Delbourg, D., Depalo, R., Descombes, T., Désesquelles, P., Detistov, P., Diarra, C., Didierjean, F., Dimmock, M. R., Doan, Q. T., Domingo Pardo, C., Doncel, M., Dorangeville, F., Dosme, N., Drouen, Y., Duchêne, G., Dulny, B., Eberth, J., Edelbruck, P., Egea, J., Engert, T., Erduran, M. N., Ertürk, S., Fanin, C., Fantinel, S., Farnea, E., Faul, T., Filliger, M., Filmer, F., Finck, C., De France, G., Gadea, A., Gast, W., Geraci, A., Gerl, J., Gernhäuser, R., Giannatiempo, A., Giaz, A., Gibelin, L., Givechev, A., Goel, N., González, V., Gottardo, A., Grave, X., Grȩbosz, J., Griffiths, R., Grint, A. N., Gros, P., Guevara, L., Gulmini, M., Görgen, A., Ha, H. T. M., Habermann, T., Harkness, L. J., Harroch, H., Hauschild, K., He, C., Hernández Prieto, A., Hervieu, B., Hess, H., Hüyük, T., Ince, E., Isocrate, R., Jaworski, G., Johnson, A., Jolie, J., Jones, P., Jonson, B., Joshi, P., Judson, D. S., Jungclaus, A., Kaci, M., Karkour, N., Karolak, M., Kaşkaş, A., Kebbiri, M., Kempley, R. S., Khaplanov, A., Klupp, S., Kogimtzis, M., Kojouharov, I., Korichi, A., Korten, W., Kröll, T., Krücken, R., Kurz, N., Ky, B. Y., Labiche, M., Lafay, X., Lavergne, L., Lazarus, I. H., Leboutelier, S., Lefebvre, F., Legay, E., Legeard, L., Lelli, F., Lenzi, S. M., Leoni, S., Lermitage, A., Lersch, D., Leske, J., Letts, S. C., Lhenoret, S., Lieder, R. M., Linget, D., Ljungvall, J., Lopez Martens, A., Lotodé, A., Lunardi, S., Maj, A., Van Der Marel, J., Mariette, Y., Marginean, N., Marginean, R., Maron, G., Mather, A. R., Mȩczyński, W., Mendéz, V., Medina, P., Melon, B., Menegazzo, R., Mengoni, D., Merchan, E., Mihailescu, L., Michelagnoli, C., Mierzejewski, J., Milechina, L., Million, B., Mitev, K., Molini, P., Montanari, D., Moon, S., Morbiducci, F., Moro, RENATA EMILIA MARIA, Morrall, P. S., Möller, O., Nannini, A, Napoli, D. R., Nelson, L., Nespolo, M., Ngo, V. L., Nicoletto, M., Nicolini, R., Le Noa, Y., Nolan, P. J., Norman, M., Nyberg, J., Obertelli, A., Olariu, A., Orlandi, R., Oxley, D. C., Özben, C., Ozille, M., Oziol, C., Pachoud, E., Palacz, M., Palin, J., Pancin, J., Parisel, C., Pariset, P., Pascovici, G., Peghin, R., Pellegri, L., Perego, A., Perrier, S., Petcu, M., Petkov, P., Petrache, C., Pierre, E., Pietralla, N., Pietri, S., Pignanelli, M., Piqueras, I., Podolyak, Z., Le Pouhalec, P., Pouthas, J., Pugnére D., L, Pucknell, V. F. E., Pullia, A., Quintana, B., Raine, R., Rainovski, G., Ramina, L., Rampazzo, G., LA RANA, Giovanni, Rebeschini, M., Recchia, F., Redon N., L, Reese M., C, Reiter, P., Regan, P. H., Riboldi, S., Richer, M., Rigato, M., Rigby, S., Ripamonti, G., Robinson, A., Robin, J., Roccaz, J., Ropert, J. A., Rossé, B. l., Rossi Alvarez, C., Rosso, D., Rubio, B., Rudolph, D., Saillant, F., Şahin, E., Salomon, F., Salsac, M. D., Salt, J., Salvato, G., Sampson, J., Sanchis, E., Santos, C., Schaffner, H., Schlarb, M., Scraggs, D. P., Seddon, D., Şenyiǧit, M., Sigward, M. H., Simpson, G., Simpson, J., Slee, M., Smith, J. F., Sona, P., Sowicki, B., Spolaore, P., Stahl, C., Stanios, T., Stefanova, E., Stézowski, O., Strachan, J., Suliman, G., Söderström, P. A., Tain, J. L., Tanguy, S., Tashenov, S., Theisen, C. h., Thornhill, J., Tomasi, F., Toniolo, N., Touzery, R., Travers, B., Triossi, A., Tripon, M., Tun Lanoë, K. M. M., Turcato, M., Unsworth, C., Ur, C. A., Valiente Dobon, J. J., Vandone, V., Vardaci, Emanuele, Venturelli, R., Veronese, F., Veyssiere, C., Viscione, E., Wadsworth, R., Walker, P. M., Warr, N., Weber, C., Weisshaar, D., Wells, D., Wieland, O., Wiens A., U, Wittwer, G., Wollersheim, H. J., Zocca, F., Zamfir, N. V., Ziȩbliński, M., Zucchiatti, A., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and 0-Belirlenecek

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Pulse-shape and gamma-ray tracking algorithms, FOS: Physical sciences, Semiconductor detector performance and simulations, Integrated circuit, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Tracking (particle physics), gamma-Ray tracking, 01 natural sciences, Pulse-shape and γ-ray tracking algorithms, law.invention, Data acquisition, law, 0103 physical sciences, ddc:530, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment (nucl-ex), 010306 general physics, γ-Ray spectroscopy, Nuclear Experiment, Instrumentation, Digital signal processing, Event reconstruction, gamma-Ray spectroscopy, Physics, sezele, Spectrometer, Spectrometers, 010308 nuclear & particles physics, business.industry, Detector, AGATA, Digital signals, HPGe detectors, Pulse-shape, Ray tracking, HPGe detectors, Algorithms, Crystals, Germanium, Semiconductor detectors, Signal processing, Spectrometry, Tracking (position), γ-Ray tracking, Instrumentation and Detectors (physics.ins-det), AGATA, Física nuclear, business, Computer hardware
Abstract

WOS: 000300864200005, The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation gamma-ray spectrometer. AGATA is based on the technique of gamma-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a gamma ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of gamma-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector-response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. (C) 2011 Elsevier B.V. All rights reserved., EU [RII3-CT-2004-506065]; German BMBF [06K-167, 06KY2051]; Swedish Research Council; Knut and Alice Wallenberg Foundation; UK EPSRC Engineering and Physical Sciences Research Council; UK STFC Science and Technology Facilities Council; AWE plc; Scientific and Technological Research Council of Turkey [106T055]; Ankara University [05B4240002]; Polish Ministry of Science and Higher Education [DPN/N190/AGATA/2009]; Spanish MICINN [FPA2008-06419, FPA2009-13377-C02-02]; Spanish Consolider-Ingenio Programme CPAN [CSD2007-00042]; Generalitat Valenciana [PROMETEO/2010/101]; MICINN, Spain; INFN, Italy [AIC10-D-000568]; Science and Technology Facilities Council [ST/F012039/1, ST/J000094/1, ST/F004192/1, ST/J000159/1, ST/I504940/1, NuSTAR, ST/F006950/1, ST/I504916/1, ST/G000670/1, ST/F004060/1, ST/J000051/1, ST/J000108/1, ST/G000670/1 NuSTAR, ST/I504959/1, ST/G000727/1, ST/F004052/1, ST/F004184/1], AGATA and this work is supported by the European funding bodies and the EU Contract RII3-CT-2004-506065, the German BMBF under Grants 06K-167 and 06KY2051, the Swedish Research Council and the Knut and Alice Wallenberg Foundation, UK EPSRC Engineering and Physical Sciences Research Council, UK STFC Science and Technology Facilities Council, AWE plc, Scientific and Technological Research Council of Turkey (Proj. nr. 106T055) and Ankara University (BAP Proj. nr. 05B4240002), the Polish Ministry of Science and Higher Education under Grant DPN/N190/AGATA/2009, the Spanish MICINN under grants FPA2008-06419 and FPA2009-13377-C02-02, the Spanish Consolider-Ingenio 2010 Programme CPAN (contract number CSD2007-00042) the Generalitat Valenciana under Grant PROMETEO/2010/101, and research performed in the frame of the GSI-IN2P3 collaboration agreement number 02-42. A. Gadea and E. Farnea acknowledge the support of MICINN, Spain, and INFN, Italy, through the AIC10-D-000568 bilateral action.

Published
2012
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11. Quantitative analysis of the debonding structure of soft adhesives.

Author

Tanguy F, Nicoli M, Lindner A, and Creton C

Abstract

We experimentally investigate the growth dynamics of cavities nucleating during the first stages of debonding of three different model adhesives. The material properties of these adhesives range from a more liquid-like material to a soft viscoelastic solid and are carefully characterized by small strain oscillatory shear rheology as well as large strain uniaxial extension. The debonding experiments are performed on a probe tack set-up. Using high contrast images of the debonding process and precise image analysis tools, we quantify the total projected area of the cavities, the average cavity shape and growth rate and link these observations to the material properties. These measurements are then used to access corrected effective stress and strain curves that can be directly compared to the results from the uniaxial extension.

Published
2014
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12. Targeting the human parasite Leishmania donovani: discovery of a new promising anti-infectious pharmacophore in 3-nitroimidazo[1,2-a]pyridine series.

Author

Castera-Ducros C, Paloque L, Verhaeghe P, Casanova M, Cantelli C, Hutter S, Tanguy F, Laget M, Remusat V, Cohen A, Crozet MD, Rathelot P, Azas N, and Vanelle P

Subjects
Animals, Antiprotozoal Agents chemical synthesis, Antiprotozoal Agents toxicity, Cell Line, Cell Survival drug effects, Drug Evaluation, Preclinical, Hep G2 Cells, Humans, Imidazoles chemical synthesis, Imidazoles toxicity, Mice, Pyridines chemical synthesis, Pyridines toxicity, Structure-Activity Relationship, Antiprotozoal Agents chemistry, Antiprotozoal Agents pharmacology, Imidazoles chemistry, Imidazoles pharmacology, Leishmania donovani drug effects, Pyridines chemistry, Pyridines pharmacology
Abstract

We report herein the discovery of antileishmanial molecules based on the imidazo[1,2-a]pyridine ring. In vitro screenings of imidazopyridines belonging to our chemical library, toward the promastigotes stage of Leishmania donovani, J774A.1 murine and HepG2 human cells, permitted to identify three selective hit-compounds (12, 20 and 28). New derivatives were then synthesized to allow structure-activity and -toxicity relationships analyses, enabling to characterize a lead-compound (44) displaying both a high potency (IC50=1.8 μM) and a good selectivity index, in comparison with three antileishmanial reference drug-compounds (amphotericin B, miltefosine and pentamidine). Moreover, lead-compound 44 also exhibits good in vitro activity against the intracellular amastigote stage of L. donovani. Thus, the 6-halo-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridine scaffold appears as a new promising selective antileishmanial pharmacophore, especially when substituted at position 8 by a bromine atom., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

Published
2013
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13. The value of immunohistological techniques in undifferentiated cancers.

Author

Coindre JM, Tanguy F, Merlío JP, De Mascarel I, De Mascarel A, and Trojani M

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Carcinoma diagnosis, Child, Female, Histocytochemistry, Humans, Immunoenzyme Techniques, Lymphoma diagnosis, Male, Middle Aged, Neoplasms analysis, Neoplasms therapy, Prognosis, Neoplasms diagnosis
Abstract

From 1980 to 1984, we observed 144 undifferentiated cancers, of which 116 (0.9% of all cancers treated during this period) were treated in our center. Immunohistochemical study classified 130 tumors (90%), which comprised 82 non-Hodgkin's lymphomas (57%), 32 carcinomas (22%), 7 melanomas (5%), 7 sarcomas (5%) and 2 others (1%). Sixty-nine patients, with the diagnostic problem of non-Hodgkin's lymphoma versus carcinoma, which was solved by immunohistology, were followed up for 44 +/- 20 months. Lymphomas (57 cases) had a better clinical course than carcinomas (11 cases), and a clinical course similar to high-grade lymphomas identified by conventional histology. For 66 patients with the same problem, the treatment was started before the immunohistochemical diagnosis. This treatment was inappropriate in the light of the correct diagnosis in 16 of 66 cases (24% of all cases).

Published
1986
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