31 results on '"English, Sean J."'
Search Results
2. Chemokine Receptor 2 Is A Theranostic Biomarker for Abdominal Aortic Aneurysms
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Elizondo-Benedetto, Santiago, primary, Sastriques-Dunlop, Sergio, additional, Detering, Lisa, additional, Arif, Batool, additional, Heo, Gyu Seong, additional, Sultan, Deborah, additional, Luehmann, Hannah, additional, Zhang, Xiaohui, additional, Gao, Xuefeng, additional, Harrison, Kitty, additional, Thies, Dakkota, additional, McDonald, Laura, additional, Combadière, Christophe, additional, Lin, Chieh-Yu, additional, Kang, Yeona, additional, Zheng, Jie, additional, Ippolito, Joseph, additional, Laforest, Richard, additional, Gropler, Robert J., additional, English, Sean J., additional, Zayed, Mohamed A., additional, and Liu, Yongjian, additional
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- 2023
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3. CCR2 Positron Emission Tomography for the Assessment of Abdominal Aortic Aneurysm Inflammation and Rupture Prediction
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English, Sean J., Sastriques, Sergio E., Detering, Lisa, Sultan, Deborah, Luehmann, Hannah, Arif, Batool, Heo, Gyu Seong, Zhang, Xiaohui, Laforest, Richard, Zheng, Jie, Lin, Chieh-Yu, Gropler, Robert J., and Liu, Yongjian
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- 2020
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4. Ketosis Prevents Abdominal Aortic Aneurysm Rupture Through CCR2 Downregulation and Enhanced MMP Balance
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Sastriques-Dunlop, Sergio, primary, Elizondo-Benedetto, Santiago, additional, Arif, Batool, additional, Meade, Rodrigo, additional, Zaghloul, Mohamed S., additional, English, Sean J., additional, Liu, Yongjian, additional, and Zayed, Mohamed A., additional
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- 2023
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5. Utility of 18 F-FDG and 11C-PBR28 microPET for the assessment of rat aortic aneurysm inflammation
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English, Sean J, Diaz, Jose A, Shao, Xia, Gordon, David, Bevard, Melissa, Su, Gang, Henke, Peter K, Rogers, Virginia E, Upchurch, Gilbert R, and Piert, Morand
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- 2014
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6. Abstract 9713: Ketosis Decreases Murine Plaque and Aortic Aneurysm Formation
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Sastriques Dunlop, Sergio E, primary, Elizondo Benedetto, Santiago, additional, Arif, Batool, additional, and English, Sean J, additional
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- 2021
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7. The natural history of splanchnic artery aneurysms and outcomes after operative intervention
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Corey, Michael R., Ergul, Emel A., Cambria, Richard P., English, Sean J., Patel, Virendra I., Lancaster, Todd R., Kwolek, Christopher J., and Conrad, Mark F.
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- 2016
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8. Ketosis Decreases β-aminopropionitrile-driven Rat Abdominal Aortic Aneurysm Rupture
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Benedetto, Santiago E., primary, English, Sean J., additional, Sastriques, Sergio E., additional, and Arif, Batool, additional
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- 2021
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9. Commentary: Neighbors should keep their distance after esophagectomy
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Nava, Ruben G., primary, English, Sean J., additional, and Kreisel, Daniel, additional
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- 2021
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10. Management of Seat Belt–type Blunt Abdominal Aortic Trauma and Associated Injuries in Pediatric Patients
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Jammeh, Momodou L., primary, Ohman, J. Westley, additional, Reed, Nanette R., additional, English, Sean J., additional, Jim, Jeffrey, additional, and Geraghty, Patrick J., additional
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- 2020
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11. 18F-FDG PET is a Useful Test to Evaluate Inflammation Associated with Human Abdominal Aortic Aneurysm Development
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English, Sean J., Davis, Frank M., Diaz, Jose A., English, Janet A., Watt, Tessa, Stone, James R., Piert, Morand R., and Upchurch, Gilbert R., Jr.
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- 2013
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12. Carotid artery stenting: Identification of risk factors for poor outcomes
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Jackson, Benjamin M., English, Sean J., Fairman, Ronald M., Karmacharya, Jagajan, Carpenter, Jeffrey P., and Woo, Edward Y.
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- 2008
13. Axillobifemoral Bypass Grafting in the Twenty-First Century
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English, Sean J. and Watkins, Michael T.
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- 2017
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14. Pathogenesis of Abdominal Aortic Aneurysms
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English, Sean J. and Upchurch, Gilbert R., Jr.
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- 2014
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15. Abstract 24: NETosis is Associated with Abdominal Aortic Aneurysm Rupture
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English, Sean J, primary, Albadawi, Hassan, additional, Yoo, Hyung-Jin, additional, Martinod, Kimberly, additional, Diaz, Jose A, additional, Meher, Akshaya, additional, Upchurch, Gilbert R, additional, Wagner, Denisa, additional, and Watkins, Michael T, additional
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- 2016
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16. SS24. The Natural History of Splanchnic Artery Aneurysms (SAAs) and Outcomes Following Operative Intervention
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Corey, Michael R., primary, Ergul, Emel A., additional, English, Sean J., additional, Patel, Virendra I., additional, Lancaster, Robert T., additional, Kwolek, Christopher J., additional, Cambria, Richard P., additional, and Conrad, Mark F., additional
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- 2015
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17. Increased 18F-FDG Uptake Is Predictive of Rupture in a Novel Rat Abdominal Aortic Aneurysm Rupture Model
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English, Sean J., primary, Piert, Morand R., additional, Diaz, Jose A., additional, Gordon, David, additional, Ghosh, Abhijit, additional, D'Alecy, Louis G., additional, Whitesall, Steven E., additional, Sharma, Ashish K., additional, DeRoo, Elise P., additional, Watt, Tessa, additional, Su, Gang, additional, Henke, Peter K., additional, Eliason, Jonathan L., additional, Ailawadi, Gorav, additional, and Upchurch, Gilbert R., additional
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- 2015
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18. Contributors
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Abbas, Abbas El-Sayed, Abdullah, Fizan, Abood, Gerard J., Abularrage, Christopher J., AbuRahma, Ali F., AbuRahma, Zachary T., Adams, David B., Afaneh, Cheguevara, Agopian, Vatche G., Ahmed, Ali Karim, Ahrendt, Steven A., Ahuja, Nita, Ahuja, Nitin K., Alarcon, Louis H., Albuja-Cruz, Maria B., Althans, Alison R., Althumairi, Azah A., Alverdy, John C., Anandam, Joselin L., Androes, Mark P., Ansari, Amir Mehdi, Arnaoutakis, Dean J., Arnold, Meghan A., Atallah, Chady I., Auchincloss, Hugh G., Axtell, Andrea L., Ayoung-Chee, Patricia, Azad, Nilofer, Azar, Faris K., Azoury, Saïd C., Bailey, Christina E., Bailey, Ian B., Balch, Charles M., Balch, Glen C., Ball, Chad G., Bandyk, Dennis F., Barie, Philip S., Bates, Andrew, Battafarano, Richard, Beard, Kristin Wilson, Beaulieu, Peter, Beaulieu, Robert J., Bedine, Marshall S., Bedzra, Edo K.S., Beekmann, Susan E., Behrns, Kevin E., Bellistri, John-Paul, Bello, Ricardo J., Benrashid, Ehsan, Berger, David L., Berian, Julia R., Bilimoria, Karl Y., Bjurlin, Marc A., Black, James H., III, Bland, Kirby, Blas, Joseph-Vincent V., Bleier, Joshua I., Blumetti, Jennifer, Bodzin, Adam, Boone, Brian A., Born, Louis J., Boughey, Judy C., Boyett, Daniel, Brady, Justin T., Brennan, Murray F., Brenner, Bruce M., Britt, L.D., Brock, Malcolm, Brownie, Evan R., Brunicardi, F. Charles, Brunt, L. Michael, Burgess, Jessica, Burke, Mark S., Burlew, Clay Cothren, Bush, Errol, Busuttil, Ronald W., Caffrey, Julie, Callender, Glenda G., Cambria, Richard P., Cameron, Andrew M., Camp, Melissa S., Campbell, Kurtis A., Carr, Shamus R., Cavnar, Michael J., Chaikof, Elliot L., Champagne, Bradley J., Haito Chavez, Yamile, Chen, Herbert, Chen, Yen-I, Chi, Albert, Chockalingam, Arun, Cholewczynski, Walter, Choti, Michael A., Christakis, Ioannis A., Christante, Dara H., Cintron, Jose R., Claridge, Jeffrey A., Clark, Damon, Cody, Hiram S., III, Cogbill, Thomas H., Cohan, Jessica N., Cooney, Damon S., Cooper, Zara, Corey, Britney L., Coté, Gregory A., Cox, Morgan L., Crawford, Todd C., Croce, Martin A., Cryer, H. Gill, Cuff, Robert F., Cunningham, Steven C., Dackiw, Alan P.B., Dagher, Nabil N., Dart, Benjamin W., IV, Datta, Jashodeep, Dattilo, Jeffery B., Davis, Bradley, Davis, Donald, Delaney, Conor P., Delman, Keith, DeMatteo, Ronald P., DeMeester, Steven R., DeMeester, Tom R., Dempsey, Daniel T., DiBrito, Sandra R., Dimick, Justin B., Dimou, Francesca M., Dixon, Peter, Donahue, James, Duh, Quan-Yang, Duncan, Mark, Durand, Christine M., Durazo, Francisco A., Earle, David, Edil, Barish H., Efron, David T., Efron, Jonathan E., Ehlert, Bryan A., Eisele, David W., Elliott, David, English, Sean J., Eriksen, Calvin, Eslami, Mohammad H., Esquivel, Jesus, Euhus, David M., Eun, John C., Evans, Douglas B., Evans, Heather L., Fabian, Timothy C., Fabri, Peter J., Fabrizio, Anne C., Fagenholz, Peter J., Fakhry, Carole, Fang, Sandy H., Fantus, Richard J., Feldman, Liane S., Feliciano, David V., Feller-Kopman, David, Ferrada, Paula A., Ferrari, Linda, Ferson, Peter F., Fichera, Alessandro, Fiedler, Amy G., Finnerty, Brendan M., Fischer, Josef E., Fisichella, P. Marco, Fleshman, James W., Fong, Zhi Ven, Forthman, Christopher L., Francone, Todd D., Frankel, Heidi, Franklin, David P., Gahtan, Vivian, Galandiuk, Susan, Gallagher, James J., Gangi, Alexandra, Garvey, Erin M., Gearhart, Susan L., Geiger, Timothy M., Gemignani, Mary L., Georgiades, Christos, Georgoff, Patrick E., Geschwind, Jean-Francois H., Gestring, Mark L., Ghaderi, Iman, Giglia, Joseph S., Giuliano, Armando E., Glebova, Natalia O., Gleisner, Ana L., Goldin, Steven B., Goldstein, Seth, Goodenough, Christopher J., Goussous, Naeem, Graham, Jay A., Grandhi, Miral Sadaria, Grant, Clive S., Gray, Richard J., Gregg, Shea C., Gribovskaja-Rupp, Irena, Griffen, Margaret M., Griffin, James F., Grimm, Joshua C., Guillem, Jose G., Ha, Jinny, Habib, Fahim, Hackam, David, Hamilton, James P., Harken, Alden H., Harmon, John W., Hartney, Mark, Hassoun, Heitham T., Haugen, Christine E., Haut, Elliott R., He, Jin, Hébert-Blouin, Marie-Noëlle, Helmink, Beth A., Henderson, David K., Heniford, B. Todd, Herline, Alan, Herman, Joseph M., Hicks, Caitlin W., Hines, O. Joe, Hogg, Melissa E., Holly, Brian P., Hong, Kelvin, Howley, Isaac W., Hoyler, Margo, Hughes, Kevin S., Hughes, Steven J., Hungness, Eric S., Hunter, John G., Hutcheon, David F., Hutter, Matthew M., Hyman, Neil H., Ignacio, Elizabeth Ann, Ijaz, Nadia, Jacobs, Lisa K., Jakhete, Neha, Jenkins, Donald H., Jensen, Robert T., Jha, Reena, Jobe, Blair A., Johnson, Eric K., Johnson, Lynt B., Joseph, Bellal, Jurkovich, Gregory J., Kadera, Brian, Kahan, Stacie A., Kaldas, Fady M., Kalloo, Anthony N., Kao, Lillian S., Kapadia, Muneera R., Kaplan, Lewis J., Kaups, Krista L., Kebebew, Electron, Kelley, Scott R., Kelly, Ronan, Kent, K. Craig, Khashab, Mouen A., Khouri, Nagi, Kim, Amy K., Kim, Karen M., Kiraly, Laszlo, Kirane, Amanda, Kleiman, David A., Klimberg, V. Suzanne, Klinger, Kerry, Knab, L. Mark, Kowdley, Gopal C., Kozarek, Richard A., Krampitz, Geoffrey W., Krezalek, Monika A., Krontiras, Helen, Krpata, David M., Kugler, Nathan, Kulkarni, Swati A., Kumbhari, Vivek, Kuwada, Timothy, Kuwayama, David, LaFace, Angela, LaMuraglia, Glenn M., Lancaster, R. Todd, Landreneau, Rodney J., Langan, Russell C., Lange, Julie R., Lay, Frank, Ledgerwood, Anna M., Lee, Andrew J., Leeper, W. Robert, Lehenbauer, David, Liddell, Robert P., Lidor, Anne, Lightner, Amy L., Lillemoe, Keith D., Lilley, Elizabeth J., Liu, Jieqiong, Liu, Yuk Ming, Loiacono, Laurie A., Lombardo, KMarie Reid, Lonze, Bonnie E., Loomis, Erica A., Lou, Irene, Lucas, Charles E., Luketich, James D., Lum, Ying Wei, Lunsford, Keri E., Lynch, Kevin, MacGillivray, Thomas E., Mackersie, Robert C., Magnuson, Thomas, Maier, Ronald V., Makary, Martin A., Makris, Konstantinos, Malangoni, Mark A., Malas, Mahmoud B., Maley, Warren R., Manson, Paul N., Mansour, M. Ashraf, Marmor, Rebecca A., Marti, Guy P., Martin, Laura, Martindale, Robert G., Mason, Leonard L., III, Mathew, Sarah Jean, Mathis, Kellie L., Mathisen, Douglas J., Matsangos, Aerielle E., Matthews, Jeffrey B., Maxwell, Robert, McCartan, Damian, McFadden, David W., McHenry, Christopher R., McIntyre, Robert C., Jr., McQuay, Nathaniel, Jr., Melancon, Joseph K., Menaker, Jay, Meneshian, Avedis, Menon, Raman, Meyer, Anthony A., Meyers, William C., Michelassi, Fabrizio, Mier, Fernando, Milner, Stephen M., Miraflor, Emily, Mitchem, Jonathan B., Moalem, Jacob, Modi, Rushabh, Molena, Daniela, Moore, Forrest O'dell, Moore, Scott M., Morse, Christopher R., Mullinax, John, Mureebe, Leila, Murphy, Adrian, Muscarella, Peter, II, Mustain, W. Conan, Myzak, Melinda Cherie, Napolitano, Lena M., Nealon, William Hawe, Netz, Uri, Neumayer, Leigh, Newman, Lisa, Ng, Christopher, Ng, Gladys, Nguyen, Hien T., Nilubol, Naris, Norton, Jeffrey A., O’Connell, Kathleen M., O’Keeffe, Terence, Okolo, Patrick I., III, O’Mara, Charles S., Osgood, Greg, Osgood, Michael J., Pachter, H. Leon, Paniccia, Alessandro, Pappas, Sam G., Pappas, Theodore N., Park, Pauline K., Parker, Catherine, Parthasarathy, Madhumithaa, Pasternak, Jesse D., Patel, Dhaval, Patel, Jayshil J., Patel, Madhukar S., Patel, Nishant, Patel, Shirali T., Paul, Jasmeet Singh, Pawlik, Timothy M., Pegoli, Walter, Jr., Peitzman, Andrew B., Pennathur, Arjun, Perler, Bruce A., Perone, Jennifer A., Perrier, Nancy D., Peters, Walter R., Phelan, Patrick J., Philosophe, Benjamin, Pieracci, Fredric M., Pitt, Henry A., Plichta, Jennifer K., Ponsky, Jeffrey L., Poor, Alexander E., Poruk, Katherine E., Prakash, Priya, Prescott, Jason D., Price, Leigh Ann, Pryor, Aurora D., Puig, Carlos A., Raeburn, Christopher D., Raigani, Siavash, Ramsay, Philip T., Rashidi, Laila, Rattner, David, Reid, Trista, Reifsnyder, Thomas, Reynolds, Jessica K., Riall, Taylor S., Rivere, Amy, Rizvi, Addi Z., Robinson, Bryce R.H., Robinson, Thomas N., Rodriguez, Aurelio, Rodriguez, John H., Rosemurgy, Alexander S., II, Rosen, Michael J., Rosso, Kelly J., Rosson, Gedge D., Rotondo, Michael F., Rueda, Mario, Ryan, Mark L., Ryer, Evan J., Sacks, Justin M., Salles, Arghavan, Santos, Byron F., Sarr, Michael G., Saur, Nicole M., Scalea, Thomas M., Schaetzel, Shaina, Schaheen, Lara, Schimpf, Dennis K., Schlachter, Todd, Schulick, Richard D., Schwartz, Diane A., Schweitzer, Michael A., Sciortino, Christopher, Semaan, Roy, Senagore, Anthony J., Shah, Amar, Shakoor, Aqsa, Shapiro, A.M. James, Shaw, Palma, Shepard, Alexander D., Sheridan, Robert, Shermak, Michele A., Sicklick, Jason K., Silverstein, Melvin, Simmons, Justin M., Sims, Carrie, Sise, Michael, Smith, Barbara L., Soares, Kevin C., Sonntag, David, Sosa, Julie A., Spain, David A., Spinner, Robert J., Stahl, Richard D., Stanley, Gregory A., Stanley, J. Daniel, Steele, Scott R., Stefanidis, Dimitrios, Stein, Sharon, Steurer, Marc P., Stevens, Kent A., Stone, Patrick A., Stonemetz, Jerry, Strasberg, Steven M., Streiff, Michael B., Stulberg, Jonah J., Sugimoto, Motokazu, Susarla, Srinivas M., Swann, Jacob, Swanstrom, Lee L., Talamini, Mark A., Tam, Vernissia, Tanabe, Kenneth K., Tarpley, John L., Taylor, Spence M., Teicher, Erik J., Teitelbaum, Ezra N., Thompson, Jon S., Thorsen, Amy J., Tieu, Alan H., Traverso, L. William, Tsai, Susan, Tsitskari, Maria, Tufaro, Anthony P., Turley, Ryan S., Udelsman, Robert, Umphrey, Heidi, Urist, Marshall, Varma, Madhulika G., Velanovich, Vic, Velmahos, George, Villano, Anthony M., Vito, Courtney A., Vollmer, Charles M., Jr., Vyas, Nilesh A., Wall, Matthew J., Jr., Waltz, Paul, Wang, Tracy S., Watkins, Michael T., Watson, Ryan S., Weaver, M. Libby, Weaver, Mitchell R., Webb, Travis P., Weber, Cynthia E., Weiss, Eric G., Weiss, Matthew J., Werner, Nicole L., Wexner, Steven D., Whyte, Richard, Wick, Elizabeth C., Wiesel, Ory, Wilson, Alison M., Wilson, Jennifer L., Winner, Megan, Witkowski, Elan R., Witkowski, Piotr, Wolf, Joshua H., Wolfgang, Christopher L., Wood, Douglas E., Wright, Cameron D., Yeo, Charles J., Yeo, Heather, Yi, Jeniann, Youngwirth, Linda M., Zarnegar, Rasa, Zeh, Herbert J., III, Zeiger, Martha A., Zenilman, Michael E., Zhan, Luke X., Zosa, Brenda M., Zoumberos, Melissa Silva, Zuberi, Kashif A., Zureikat, Amer H., and Zyromski, Nicholas J.
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- 2017
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19. Imaging of carrageenan-induced local inflammation and adjuvant-induced systemic arthritis with [11C]PBR28 PET
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Shao, Xia, primary, Wang, Xueding, additional, English, Sean J., additional, Desmond, Timothy, additional, Sherman, Phillip S., additional, Quesada, Carole A., additional, and Piert, Morand R., additional
- Published
- 2013
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20. Abstract 529: Increased 18F-FDG Uptake in the Aortic Wall of β-aminopropionitrile Exposed Rats May be Predictive of AAA Rupture
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English, Sean J, primary, Piert, Morand R, additional, Diaz, Jose A, additional, Ghosh, Abhijit, additional, Sherman, Phillip S, additional, Quesada, Carole A, additional, Pechota, Angela, additional, Eliason, Jonathan L, additional, Henke, Peter K, additional, and Upchurch, Gilbert R, additional
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- 2012
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21. Abstract 250: Increased 18F-FDG Uptake in the Aortic Wall of β-Aminopropionitrile Exposed Rats May Be Predictive of AAA Rupture
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English, Sean J, primary, Piert, Morand R, additional, Diaz, Jose A, additional, Ghosh, Abhijit, additional, Sherman, Phillip S, additional, Quesada, Carole A, additional, Pechota, Angela, additional, Eliason, Jonathan L, additional, Henke, Peter K, additional, and Upchurch, Gilbert R, additional
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- 2012
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22. Use of 18F-FDG micro-PET and autoradiography to assess inflammation associated with rat abdominal aortic aneurysm formation
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English, Sean J., primary, Piert, Morand R., additional, Sherman, Phillip S., additional, Quesada, Carole A., additional, Holt, Lawrence T., additional, DiMusto, Paul D., additional, Diaz, Jose A., additional, Henke, Peter K., additional, and Upchurch, Gilbert R., additional
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- 2011
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23. Increased 18F-FDG Uptake Is Predictive of Rupture in a Novel Rat Abdominal Aortic Aneurysm Rupture Model.
- Author
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English, Sean J., Piert, Morand R., Diaz, Jose A., Gordon, David, Ghosh, Abhijit, D'Alecy, Louis G., Whitesall, Steven E., Sharma, Ashish K., DeRoo, Elise P., Watt, Tessa, Gang Su, Henke, Peter K., Eliason, Jonathan L., Ailawadi, Gorav, and Upchurch Jr, Gilbert R.
- Published
- 2015
- Full Text
- View/download PDF
24. Influence of body temperature on the BOLD effect in murine SCC tumors†
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Reijnders, Koen, primary, English, Sean J., additional, Krishna, Murali C., additional, Cook, John A., additional, Sowers, Anastasia L., additional, Mitchell, James B., additional, and Zhang, Yantian, additional
- Published
- 2004
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25. Gadolinium-labeled dendrimers as biometric nanoprobes to detect vascular permeability
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Yordanov, Alexander T., primary, Kobayashi, Hisataka, additional, English, Sean J., additional, Reijnders, Koen, additional, Milenic, Diane, additional, Krishna, Murali C., additional, Mitchell, James B., additional, and Brechbiel, Martin W., additional
- Published
- 2003
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26. Contributors
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Abbas, Jihad, AbuRahma, Ali F., Abu-Hamilah, Shadi J., Acher, Charles W., Adelman, Mark A., Akin, Ibrahim, Akins, Cary W., Allemang, Matthew T., Almeida, Jose I., Alterman, Daniel M., Amin, Parth B., Anaya-Ayala, Javier E., Andros, George, Arnold, Margaret W., Arya, Shipra, Ascher, Enrico, Babrowicz, Joseph C., Jr., Bandyk, Dennis F., Baril, Donal T., Bassiouny, Hisham S., Bavare, Charudatta, Baxter, B. Timothy, Bazzi, Mazen, Beck, Adam W., Belczyk, Ronald J., Belkin, Michael, Bendick, Phillip J., Bensley, Rodney P., Berceli, Scott A., Bergqvist, David, Berguer, Ramon, Berland, Todd L., Bisognano, John D., Bjarnason, Haraldur, Blebea, John, Blom, Aaron S., Boatright, Cristal, Bodnar, Timothy W., Bolia, Amman, Botos, Balasz, Bower, Thomas C., Bown, Matthew J., Brewster, David C., Brook, Robert D., Brothers, Thomas E., Brownrigg, Jack, Brunkwall, Jan S., Calligaro, Keith D., Cambria, Richard P., Carpenter, James E., Carpenter, Jeffrey P., Carter, Robert, Cavanaugh, Sherrie, Cayne, Neal S., Chaer, Rabih A., Chandra, Ronil V., Chang, Alexander T., Chang, Benjamin B., Chang, Catherine K., Charlton-Ouw, Kristofer M., Cherry, Kenneth J., Cho, Kyung J., Chung, M., Chuter, Timothy A.M., Clagett, G. Patrick, Clair, Daniel G., Coleman, Dawn M., Comerota, Anthony J., Conte, Michael S., Coselli, Joseph S., Criado, Enrique, Cronenwett, Jack L., Dalman, Ronald L., Dalsing, Michael C., Darling, R. Clement, III, Dasika, Narasimham L., Davies, Alun H., Davies, Mark G., Borst, Gert Jan de, DePalma, Ralph G., Dick, Florian, Doblas, Manuel, Donas, Konstantinos P., Dong, Qian, Dougherty, Matthew J., Dougherty, Paul J., Dryjsk, Maciej, Duwayri, Yazan, Dyhdalo, Kathryn S., Eagle, Kim, Eidt, John F., Eklof, Bo G., Elias, Steve, Eliason, Jonathan L., Ellis, Jennifer, Endean, Eric D., Engelhardt, Tod C., English, Sean J., Escobar, Guillermo A., Eskandari, Mark K., Estrera, Anthony L., Fajardo, Andres, Fankhauser, Grant T., Farber, Mark A., Faries, Peter L., Farley, Steven M., Feezor, Robert J., Felty, Cindy L., Flanigan, D. Preston, Flinn, William R., Fode, Mikkel, Fontcuberta, Juan, Fox, Charles J., Friedman, Marc, Froehlich, James B., Ganesh, Santhi K., Garg, Nitin, Gargiulo, Nicholas J., III, Garland, Brandon T., Gertler, Jonathan P., Gewertz, Bruce L., Gianchandani, Roma, Gloviczki, Peter, Gohel, Manj S., Goldman, Mitchell H., Goldstone, Jerry, Gomero-Cure, Wadi, Gordon, David, Graham, Alan M., Graham, Linda M., Green, Richard M., Greenberg, Roy K., Greiner, Andreas, Greisler, Howard P., Griffin, Maura, Grommes, Jochen, Gupta, Ankur, Gurm, Hitinder S., Hallett, John W., Jr., Hansen, Kimberley J., Harris, Linda M., Harris, Robert W., Henke, Peter K., Herrera, Santiago, Hertzer, Norman R., Hingorani, Anil, Hirsch, Alan T., Hirsch, Joshua A., Ho, Karen J., Hodgkiss-Harlow, Kelley, Hollier, Larry H., Hood, Douglas B., Hopkins, L. Nelson, Huang, Joe, Huber, Thomas S., Hull, Russell D., Humphries, Misty D., Hurie, Justin, Hurks, Rob, Hynes, Niamh, Illig, Karl A., Jackson, Elizabeth A., Jacobs, Michael J., Jaff, Michael R., Jahshan, Shady, Jamieson, Stuart W., Jimenez, Juan Carlos, Johansen, Kaj H., Johnston, K. Wayne, Kalman, Peter G., Kan, Peter, Kang, Edward P., Karam, Joseph, Kass-Hout, Omar, Kashyap, Vikram, Keagy, Blair A., Kelly, Brian M., Kelso, Rebecca L., Kent, K. Craig, Kermani, Tanaz A., Kibbe, Melina R., Kische, Stephan, Kistner, Robert L., Knepper, Jordan, Kolvenbach, Ralf R., Kopchok, George, Kreienberg, Paul B., Kresowik, Timothy F., Kret, Marcus R., Kristo, Gentian, Labropoulos, Nicos, Lachat, Mario, Lal, Brajesh K., LaMuraglia, Glenn M., Lancaster, Robert T., Laredo, James, Leal, Ignacio, Lederle, Frank A., Lee, Byung-Boong, Lee, W. Anthony, LeMaire, Scott A., Leonard, James A., Jr., Leslie-Mazwi, Thabele M., Levy, Elad I., Liem, Timothy K., Lin, Peter H., Liu, Peter S., Wei Lum, Ying, Lumsden, Alan B., Lyden, Sean P., Ma, Harry, Mackey, William C., MacTaggart, Jason, Madani, Michael, Makaroun, Michel S., Malek, Adel M., Malgor, Rafael D., Malhotra, Kirti, Manis, George, Marin, Michael L., Markov, Nickolay P., Marks, Natalie, Martindale, S., Matsumura, Jon S., Mayer, Dieter, McCarthy, Walter, McIntyre, Kenneth E., Jr., McPhee, James T., Mehta, Manish, Meissner, Mark H., Menes, Keith C., Messina, Louis M., Mills, Joseph L., Sr., Mitchell, Erica, Modrall, J. Gregory, Moll, Frans L., Moneta, Gregory L., Money, Samuel R., Moore, Wesley S., Morasch, Mark D., Moreira, Edward S., Orgaz, Antonio, Morrison, Nick, Mousa, Albeir Y., Muthappan, Palaniappan, Myers, Daniel D., Jr., Myers, Stuart I., Naylor, A. Ross, Nelms, Justin K., Neschis, David G., Neville, Richard F., Nguyen, Bao-Ngoc, Nicholson, Rachael, Nicolaides, Andrew N., Nienaber, Christoph A., Novelli, Paula, Nypaver, Timothy J., O'Brien, Gavin C., Ochoa, Christian J., O'Connor, David J., Oderich, Gustavo S., O'Donnell, Thomas F., Jr., Oh, Daniel C., O'Hara, Patrick J., Ohl, Dana A., Oreopoulos, George D., Orion, David, Osborne, Nicholas H., Ozaki, C. Keith, Ozsvath, Kathleen J., Padberg, Frank T., Jr., Pappas, Peter J., Parodi, Ezequiel, Parodi, Juan, Patel, Himanshu J., Patel, Madhukar S., Patel, Mitul Suresh, Patel, Virendra I., Paty, Philip S.K., Pfammatter, Thomas, Pearce, William H., Pecoraro, Felice, Perler, Bruce A., Peterson, Brian G., Poi, Mun Jye, Pomposelli, Frank B., Jr., Pourrabbani, Shahin, Powell, Janet T., Powell, Richard J., Power, Adam H., Pretorius, Victor, Prince, Martin R., Qasabian, Raffi A., Quallich, Susanne A., Quinones-Baldrich, William J., Raffetto, Joseph, Rahbar, Rodeen, Rahimi, Saum A., Raju, Seshadri, Rancic, Zoran, Rasmussen, Todd E., Rectenwald, John E., Reddy, Daniel J., Rehders, Tim C., Reichmann, Boudewijn L., Reilly, Linda M., Rich, Norman M., Ricotta, John J., Riles, Thomas S., Ritter, Wolfgang, Rivera, Askin G., Robinson, William P., III, Rockman, Caron B., Roddy, Sean P., Rodriguez, Heron E., Rogers, Lee, Rooke, Thom W., Rowe, Vincent L., Ryjewski, Connie, Sadek, Mikel, Safi, Hazim J., Santilli, Steven M., Sarac, Timur P., Sarraf, Mohammad, Scali, Salvatore T., Schermerhorn, Marc L., Schmaier, Alvin H., Schneider, Joseph R., Schneider, Peter A., Schoenberg, Stefan, Schonholz, Claudio J., Shah, Dhiraj M., Shalhub, Sherene, Shames, Murray L., Sharafuddin, Melhem J., Shea, Evelyn M., Sheahan, Claudie M., Sheahan, Malachi G., III, Shepard, Alexander D., Shields, James, Sicard, Gregario A., Sidawy, Anton N., Siddiqui, Adnan H., Sisson, Thomas H., Smith, Brigitte K., Smolock, Christopher J., Sonksen, Jens, Sos, Thomas A., Southern, Fredrick N., Srivastava, Sunita, Stanley, Gregory A., Stanley, James C., Stanson, Anthony W., Stellar, Courtney, Sternbergh, W. Charles, III, Stone, David H., Stone, Patrick A., Stone, William M., Stoneham, Mark D., Strick, David, Sultan, Sherif, Svensson, Lars G., Svoboda, Ryan M., Tambyraja, Andrew L., Tawfick, Wael, Taylor, Nyali E., Thai, Janice, Thompson, Matthew M., Thompson, Robert W., Tielliu, Ignace F.J., Titus, Jessica M., Torrance, Bruce, Torsello, Giovanni, Treiman, Gerald S., Treiman, Richard L., Trinidad-Hernandez, Magdiel, Turnipseed, William, Ucuzian, Areck A., Upchurch, Gilbert R., Jr., Usatii, Anatolie, van Bockel, J. Hajo, van den Berg, Jos C., Vandy, Frank C., Vargas, Lina M., Varma, Manish, Vartanian, Shant M., Vega de Céniga, Melina, Veith, Frank J., Vemuri, Chandu, Verhoeven, Eric L.G., Villavicencio, J. Leonel, Visser, Michel J.T., Vogel, David L., Vykoukal, Daynene, Wakefield, Thomas W., Walsh, Daniel B., Warber, Sara L., Warrington, Kenneth, Waters, Peadar, Weaver, Fred A., Weaver, Mitchell R., Weder, Alan B., Weinberg, Ido, Welling, David R., White, Geoffrey H., White, John V., White, Rodney A., Whittemore, Anthony D., Williams, David M., Williams, Russell A., Wilson, Samuel E., Woo, Edward Y., Woo, Karen, Wynn, Martha M., Wyss, Thomas R., Xu, Chengpei, Yao, James S.T., Yoo, Albert J., Young, Phillip M., Zarins, Christopher K., Zayed, Mohamed A., Zelenock, Gerald B., and Zierler, R. Eugene
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- 2014
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27. Abstract 14764: A Theranostic Role for C-C Chemokine Receptor 2 in the Management of Rodent Abdominal Aortic Aneurysm Development and Rupture
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Sastriques, Sergio E, Detering, Lisa M, Sultan, Deborah H, Luehmann, Hannah P, Arif, Batool, Gropler, Robert J, Lin, Chieh-Yu, Zheng, Jie, Liu, Yongjian, and English, Sean J
- Abstract
Introduction:Abdominal Aortic Aneurysm (AAA) development is common in the aging population, and AAA rupture carries a high mortality. AAA development is characterized by destructive extracellular matrix remodeling by mononuclear phagocytes. Monocyte chemoattractant protein/C-C chemokine receptor type 2 (CCR2) axis plays an important role in AAA development. We sought to evaluate if increased rat AAA uptake of 64Cu-DOTA-ECL1i, a radiolabeled CCR2 binding peptide, by positron emission tomography (PET) imaging, is predictive of subsequent rupture. We also sought to determine if CCR2 inhibition can prevent AAA rupture.Methods:Forty-three male Sprague-Dawley rats underwent intraluminal aortic exposure to porcine pancreatic elastase (PPE) to induce aneurysmal degeneration. Four groups were considered: 1. Active PPE (AAA), 2. Heat-inactivated PPE (Control), 3. APPE + ?-aminopropionitrile (BAPN), a lysyl oxidase inhibitor to stimulate AAA rupture (RAAA), and 4. APPE + BAPN + RS-504393, a CCR2 inhibitor (TxAAA). 64Cu-DOTA-ECL1i PET imaging was performed 7 and 14 days post AAA induction.Results:AAAs demonstrated significantly greater 64Cu-DOTA-ECL1i uptake by PET imaging compared to controls (p<0.05), and this was confirmed by autoradiography. RAAAs that subsequently ruptured demonstrated significantly greater 64Cu-DOTA-ECL1i uptake compared to those that did not (p<0.001 ). RAAAs ruptured at a rate of 49%, with a mean aortic diameter increase of 345 % ? 35 %, while TxAAAs did not generate aneurysms and ruptured at a rate of 20%, with a mean aortic diameter increase of 85 % ? 6 % (p<0.0001). As an additional marker of macrophage presence, TxAAA MMP9 activity by zymography was significantly lower than that of AAAs and RAAAs that did not rupture (p<0.05).Conclusions:CCR2 targeted PET imaging demonstrated inflammation associated with rat AAA development. Increased radiotracer uptake by AAAs that subsequently rupture warrants further study to determine the ability of 64Cu-DOTA-ECL1i PET imaging to aid in assessing AAA rupture potential. CCR2 inhibition with our model decreases AAA development and prevents AAA rupture, suggesting a theranostic role for CCR2 in the treatment of AAA patients.
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- 2019
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28. Gadolinium-labeled dendrimers as biometric nanoprobes to detect vascular permeability
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YordanovPresent address: Department of Radiology, Alexander T., 3808, Box, Center, Duke University Medical, Durham, Kobayashi, Hisataka, English, Sean J., Reijnders, Koen, Milenic, Diane, Krishna, Murali C., Mitchell, James B., and Brechbiel, Martin W.
- Abstract
PAMAM dendrimer-based biometric nanoprobes G4-1B4M-Gd, G6-1B4M-Gdand G8-1B4M-Gdwere used to detect vascular permeability in SCCVII mice tumors. Based on the whole body clearance curve, G8-1B4M-Gdemerged as the ideal candidate for vascular permeability imaging studies due to its stable signal enhancement in the tumor over time. A 2D MR image of a SCCVII tumor showed vessel enhancement without obvious diffuse enhancement.
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- 2003
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29. Imaging of carrageenan-induced local inflammation and adjuvant-induced systemic arthritis with [11C]PBR28 PET.
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Shao, Xia, Wang, Xueding, English, Sean J., Desmond, Timothy, Sherman, Phillip S., Quesada, Carole A., and Piert, Morand R.
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CARRAGEENANS , *POSITRON emission tomography , *INFLAMMATION , *ARTHRITIS , *MYCOBACTERIUM , *MACROPHAGE activation - Abstract
Abstract: Introduction: [11C] PBR28 binding to translocator protein (TSPO) was evaluated for imaging of acute and chronic inflammation using two established rat models. Methods: Acute inflammation was induced by local carrageenan injection into the paw of Fisher 344 rats (model A). T-cell mediated adjuvant arthritis was induced by heat-inactivated Mycobacterium butyricum injection in Lewis rats (model B). Micro-PET scan was performed after injection of approximately 35 MBq [11C]PBR28. In model A, volumes of interest (VOIs) were defined in the paw of Fisher 344 rats (n=6) with contralateral sham treatment as control. For model B, VOIs were defined in the tail, sacroiliac joints, hips, knees and thigh muscles of M. butyricum treated animals (n=8) and compared with sham-treated controls (n=4). The peak 11C-PBR28 SUV (SUVpeak ) and area under the curve (AUCSUV ) of 60-minute time-activity data were calculated. Immunohistochemistry for CD68, a macrophage stain, was performed from paw tissues. In addition, the [11C]PBR28 cell uptake was measured in lipopolysaccharide (LPS)-stimulated and non-stimulated macrophage cultures. Results: LPS-stimulated macrophages displayed dose-dependent increased [11C]PBR28 uptake, which was blocked by non-labeled PBR28. In both models, radiotracer uptake of treated lesions increased rapidly within minutes and displayed overall accumulative kinetics. The SUVpeak and AUCSUV of carrageenan-treated paws was significantly increased compared to controls. Also, the [11C]PBR28 uptake ratio of carrageenan-treated vs. sham-treated paw correlated significantly with CD68 staining ratios of the same animals. In adjuvant arthritis, significantly increased [11C]PBR28 SUVpeak and AUCSUV values were identified at the tail, knees, and sacroiliac joints, while no significant differences were identified in the lumbar spine and hips. Conclusions: Based on our initial data, [11C]PBR28 PET appears to have potential for imaging of various inflammatory processes involving macrophage activation. [Copyright &y& Elsevier]
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- 2013
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30. Chemokine Receptor 2 Is A Theranostic Biomarker for Abdominal Aortic Aneurysms.
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Elizondo-Benedetto S, Sastriques-Dunlop S, Detering L, Arif B, Heo GS, Sultan D, Luehmann H, Zhang X, Gao X, Harrison K, Thies D, McDonald L, Combadière C, Lin CY, Kang Y, Zheng J, Ippolito J, Laforest R, Gropler RJ, English SJ, Zayed MA, and Liu Y
- Abstract
Abdominal aortic aneurysm (AAA) is a degenerative vascular disease impacting aging populations with a high mortality upon rupture. There are no effective medical therapies to prevent AAA expansion and rupture. We previously demonstrated the role of the monocyte chemoattractant protein-1 (MCP-1) / C-C chemokine receptor type 2 (CCR2) axis in rodent AAA pathogenesis via positron emission tomography/computed tomography (PET/CT) using CCR2 targeted radiotracer
64 Cu-DOTA-ECL1i. We have since translated this radiotracer into patients with AAA. CCR2 PET showed intense radiotracer uptake along the AAA wall in patients while little signal was observed in healthy volunteers. AAA tissues collected from individuals scanned with64 Cu-DOTA-ECL1i and underwent open-repair later demonstrated more abundant CCR2+ cells compared to non-diseased aortas. We then used a CCR2 inhibitor (CCR2i) as targeted therapy in our established male and female rat AAA rupture models. We observed that CCR2i completely prevented AAA rupture in male rats and significantly decreased rupture rate in female AAA rats. PET/CT revealed substantial reduction of64 Cu-DOTA-ECL1i uptake following CCR2i treatment in both rat models. Characterization of AAA tissues demonstrated decreased expression of CCR2+ cells and improved histopathological features. Taken together, our results indicate the potential of CCR2 as a theranostic biomarker for AAA management.- Published
- 2023
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31. Ketosis Prevents Abdominal Aortic Aneurysm Rupture Through CCR2 Downregulation and Enhanced MMP Balance.
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Sastriques-Dunlop S, Elizondo-Benedetto S, Arif B, Meade R, Zaghloul MS, English SJ, Liu Y, and Zayed MA
- Abstract
Abdominal aortic aneurysms (AAAs) are common in aging populations, and AAA rupture is associated with high morbidity and mortality. There is currently no effective medical preventative therapy for AAAs to avoid rupture. It is known that the monocyte chemoattractant protein (MCP-1) / C-C chemokine receptor type 2 (CCR2) axis critically regulates AAA tissue inflammation, matrix-metalloproteinase (MMP) production, and in turn extracellular matrix (ECM) stability. However, therapeutic modulation of the CCR2 axis for AAA disease has so far not been accomplished. Since ketone bodies (KBs) are known to trigger repair mechanisms in response to vascular tissue inflammation, we evaluated whether systemic in vivo ketosis can impact CCR2 signaling, and therefore impact AAA expansion and rupture. To evaluate this, male Sprague-Dawley rats underwent surgical AAA formation using porcine pancreatic elastase (PPE), and received daily β-aminopropionitrile (BAPN) to promote AAA rupture. Animals with formed AAAs received either a standard diet (SD), ketogenic diet (KD), or exogenous KB supplements (EKB). Animals that received KD and EKB reached a state of ketosis, and had significantly reduced AAA expansion and incidence of rupture. Ketosis also led to significantly reduced CCR2, inflammatory cytokine content, and infiltrating macrophages in AAA tissue. Additionally, animals in ketosis had improved balance in aortic wall matrix-metalloproteinase (MMP), reduced extracellular matrix (ECM) degradation, and higher aortic media Collagen content. This study demonstrates that ketosis plays an important therapeutic role in AAA pathobiology, and provides the impetus for future studies investigating the role of ketosis as a preventative strategy for individuals with AAAs.
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- 2023
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