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2. Defining major surgical complications using administrative data in Ontario: a validation study

Author

McClure, J. Andrew, Walser, Eric, Allen, Laura, Vinden, Chris, Jones, Philip M., Dubois, Luc, and Vogt, Kelly

Subjects
Medical research, Medicine, Experimental, Medical records, Algorithms, Algorithm, Health, Health care industry
Abstract

Background: Although surgical complications are often included as an outcome of surgical research conducted using administrative data, little validation work has been performed. We sought to evaluate the diagnostic performance of an algorithm designed to capture major surgical complications using health administrative data. Methods: This retrospective study included patients who underwent high-risk elective general surgery at a single institution in Ontario, Canada, from Sept. 1, 2016, to Sept. 1, 2017. Patients were identified for inclusion using the local operative database. Medical records were reviewed by trained clinicians to abstract postoperative complications. Data were linked to administrative data holdings, and a series of code-based algorithms were applied to capture a composite indicator of major surgical complications. We used sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy to evaluate the performance of our administrative data algorithm, as compared with data abstracted from the institutional charting system. Results: The study included a total of 270 patients. According to the data from the chart audit, 55% of patients experienced at least 1 major surgical complication. Overall sensitivity, specificity, PPV, NPV and accuracy for the composite outcome was 72%, 80%, 82%, 70% and 76%, respectively. Diagnostic performance was poor for several of the individual complications. Conclusion: Our results showed that administrative data holdings can be used to capture a composite indicator of major surgical complications with adequate sensitivity and specificity. Additional work is required to identify suitable algorithms for several specific complications. Contexte : Même si les complications postopératoires sont souvent incluses parmi les paramètres mesurés lors de recherches sur la chirurgie qui reposent sur les données administratives, leur validation n'a pas fait l'objet d'études. Nous avons voulu évaluer le rendement diagnostique d'un algorithme conçu pour faire le point sur les complications postopératoires majeures à partir des données administratives sur la santé. Méthodes : Cette étude rétrospective a inclus des malades soumis à des chirurgies à haut risque non urgentes dans 1 seul établissement en Ontario, au Canada, entre le 1er septembre 2016 et le 1er septembre 2017. Les cas ont été recrutés à partir de la base de données périopératoires de l'établissement. Les dossiers médicaux ont été passés en revue par des médecins dument formés pour extraire les données concernant les complications postopératoires. Ces données ont été reliées à des registres de données administratives, et une série d'algorithmes a été appliqué pour créer un paramètre mixte des complications chirurgicales majeures. Nous avons utilisé la sensibilité, la spécificité, la valeur prédictive positive (VPP), la valeur prédictive négative (VPN) et la justesse afin d'évaluer le rendement de notre algorithme bâti sur les données administratives. plutôt que sur les données extraites du système de tenue de dossier de l'établissement. Résultats : En tout, l'étude a recruté 270 patients. Selon l'analyse des dossiers, 55% ont eu au moins 1 complication postopératoire majeure. La sensibilité, la spécificité, la VPP, la VPN et la justesse pour le paramètre mixte ont été respectivement de 72%, 80%, 82%, 70% et 76%. Le rendement diagnostique a été faible pour plusieurs complications individuelles. Conclusion : Nos résultats ont montré que les registres de données administratives peuvent servir à créer un paramètre mixte des complications postopératoires majeures avec une sensibilité et une spécificité adéquates. Il faudra approfondir la recherche pour concevoir des algorithmes adaptés à diverses complications spécifiques., Administrative databases are increasingly being used to address priorities in surgical research. Although surgical complications are often investigated as study outcomes, (1-5) little work has been done to validate the [...]

Published
2023
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8. Canadian Cardiovascular Society 2022 Guidelines for Peripheral Arterial Disease

Author

Abramson, Beth L., Al-Omran, Mohammed, Anand, Sonia S., Albalawi, Zaina, Coutinho, Thais, de Mestral, Charles, Dubois, Luc, Gill, Heather L., Greco, Elisa, Guzman, Randolph, Herman, Christine, Hussain, Mohamad A., Huckell, Victor F., Jetty, Prasad, Kaplovitch, Eric, Karlstedt, Erin, Kayssi, Ahmed, Lindsay, Thomas, Mancini, G.B John, McClure, Graham, McMurtry, M. Sean, Mir, Hassan, Nagpal, Sudhir, Nault, Patrice, Nguyen, Thang, Petrasek, Paul, Rannelli, Luke, Roberts, Derek J., Roussin, Andre, Saw, Jacqueline, Srivaratharajah, Kajenny, Stone, James, Szalay, David, Wan, Darryl, Cox, Heather, Verma, Subodh, and Virani, Sean

Published
2022
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9. Outcomes of thoracic endovascular aortic repair in patients with concomitant blunt thoracic aortic injury and traumatic brain injury from the Aortic Trauma Foundation global registry

Author

Saqib, Naveed, Charlton-Ouw, Kristofer, Afifi, Rana, McNutt, Michelle, Al-Rustum, Zain, Shrestha, Binod, Quiroga, Elina, Starnes, Ben, Gilani, Rami, Turay, David, Luo-Owen, Xian, Bee, Tiffany, Moyer, Suzanne, DuBose, Joe, Shutze, William, Dockery, William, Petrey, Laura, Phelps, Timothy N., Fox, Chuck, Moore, Ernest, Cralley, Alexis, Teixeira, Pedro, Leede, Emily, Buchanan, Frank, Ramos, Emilio, Ngoue, Marielle, Fox, Nicole, Shea, Lisa, Zielinski, Martin, Fischmann, Marianna Martini, Inaba, Kenji, Khor, Desmond, Magee, Gregory, Sheahan, Malachi, Unruh, Marie, Parry, Neil, Dubois, Luc, Berne, John, Puente, Ivan, Gomez, Mario F., Mederos, Dalier R., Bini, John, Herzing, Karen, Hardman, Claire, Schanzer, Andres, Aiello, Francesco, Arous, Edward, Arous, Elias, Jones, Douglas, Judelson, Dejah, Messina, Louis, Nguyen, Tammy, Simons, Jessica, Steppacher, Robert, Rezende-Neto, Joao, Haan, James, Lightwine, Kelly, Dunn, Julie, Smoot, Brittany, Horer, Tal, McGreevy, David, Riambau, Vincent, Mestres, Gaspar, Yugueros, Xavier, Passman, Marc, Beck, Adam W., Patterson, Mark, Pearce, Ben, Spangler, Emily, McFarland, Graeme, Sutzko, Danielle, Smeds, Matt, Zakhary, Emad, Williams, Michael, Wittgen, Catherine, Vogel, Todd, Eagleton, Matt, Azizzadeh, Ali, Gewertz, Bruce, Barmparas, Galinos, Arbabi, Cassra, DuBose, Joseph, Kundi, Rishi, Morrison, Jonathan, Rossi, Peter, Pacini, Davide, Botta, Luca, Amodio, Ciro, Rimoldi, Pierantonio, D'Alessio, Ilenia, Compagnoni, Nicola Monzio, Aftab, Muhammad, Al-Musawi, Mohammed, Reece, T. Brett, Pal, Jay D., Jacobs, Donald, Malgor, Rafael D., Zarkowsky, Devin, Rajani, Ravi, Benarroch-Gampel, Jaime, Ramos, Christopher R., Schermerhorn, Marc, Wyers, Mark, Hamdan, Allen, Stangenberg, Lars, Lee, Andy, Davies, Mark, Jayakumar, Lalithapriya (Priya), Sideman, Matthew J., Mitromaras, Christopher, Miserlis, Dimitrios, Brahmbhatt, Reshma, Darling, Ralph, Caliste, Xzabia, Chang, Benjamin B., Hnath, Jeffrey C., Kreienberg, Paul B., Kryszuk, Alexander, Laser, Adriana, Roddy, Sean P., Saltzberg, Stephanie, Shah, Melissa, Warner, Courtney, Yeh, Chin-Chin, Reva, Viktor, Zhigalo, Viktor, Krasikov, Alexander V., Trimarchi, Santi, Domanin, Maurizio, Babrowski, Trissa, Milner, Ross, Pocivavsek, Luka, Skelly, Christopher, Malka, Kimberly, Nolan, Brian, D’Oria, Mario, Lepidi, Sandro, Arbabi, Cassra N., Starnes, Benjamin W., and Miller, Charles

Published
2022
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10. Outcomes and practice patterns of medical management of blunt thoracic aortic injury from the Aortic Trauma Foundation global registry

Author

Saqib, Naveed, Charlton-Ouw, Kristofer, Afifi, Rana, McNutt, Michelle, Al-Rustum, Zain, Shrestha, Binod, Dipasupil, Edmundo, Quiroga, Elina, Starnes, Ben, Gilani, Rami, Turay, David, Luo-Owen, Xian, Bee, Tiffany, Moyer, Suzanne, DuBose, Joe, Shutze, William, Dockery, William, Petrey, Laura, Phelps, Timothy N., Fox, Chuck, Moore, Ernest, Cralley, Alexis, Teixeira, Pedro, Leede, Emily, Buchanan, Frank, Ramos, Emilio, Ngoue, Marielle, Fox, Nicole, Shea, Lisa, Zielinski, Martin, Fischmann, Marianna Martini, Inaba, Kenji, Khor, Desmond, Magee, Gregory, Sheahan, Malachi, Unruh, Marie, Parry, Neil, Dubois, Luc, Berne, John, Puente, Ivan, Gomez, Mario F., Mederos, Dalier R., Bini, John, Herzing, Karen, Hardman, Claire, Schanzer, Andres, Aiello, Francesco, Arous, Edward, Arous, Elias, Jones, Douglas, Judelson, Dejah, Messina, Louis, Nguyen, Tammy, Simons, Jessica, Steppacher, Robert, Rezende-Neto, Joao, Haan, James, Lightwine, Kelly, Dunn, Julie, Smoot, Brittany, Horer, Tal, McGreevy, David, Riambau, Vincent, Mestres, Gaspar, Yugueros, Xavier, Passman, Marc, Beck, Adam W., Patterson, Mark, Pearce, Ben, Spangler, Emily, McFarland, Graeme, Sutzko, Danielle, Smeds, Matt, Zakhary, Emad, Williams, Michael, Wittgen, Catherine, Vogel, Todd, Eagleton, Matt, Azizzadeh, Ali, Gewertz, Bruce, Barmparas, Galinos, Arbabi, Cassra, DuBose, Joseph, Kundi, Rishi, Morrison, Jonathan, Rossi, Peter, Pacini, Davide, Botta, Luca, Amodio, Ciro, Rimoldi, Pierantonio, D'Alessio, Ilenia, Compagnoni, Nicola Monzio, Aftab, Muhammad, Al-Musawi, Mohammed, Reece, T. Brett, Pal, Jay D., Jacobs, Donald, Malgor, Rafael D., Zarkowsky, Devin, Rajani, Ravi, Benarroch-Gampel, Jaime, Ramos, Christopher R., Schermerhorn, Marc, Wyers, Mark, Hamdan, Allen, Stangenberg, Lars, Lee, Andy, Davies, Mark, Jayakumar, Lalithapriya (Priya), Sideman, Matthew J., Mitromaras, Christopher, Miserlis, Dimitrios, Brahmbhatt, Reshma, Darling, Ralph, Caliste, Xzabia, Chang, Benjamin B., Hnath, Jeffrey C., Kreienberg, Paul B., Kryszuk, Alexander, Laser, Adriana, Roddy, Sean P., Saltzberg, Stephanie, Shah, Melissa, Warner, Courtney, Yeh, Chin-Chin, Reva, Viktor, Zhigalo, Viktor, Krasikov, Alexander V., Trimarchi, Santi, Domanin, Maurizio, Babrowski, Trissa, Milner, Ross, Pocivavsek, Luka, Skelly, Christopher, Malka, Kimberly, Nolan, Brian, D’Oria, Mario, Lepidi, Sandro, Arbabi, Cassra N., Starnes, Benjamin W., and Miller, Charles

Published
2022
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12. Screening for abdominal aortic aneurysms in Canada: 2020 review and position statement of the Canadian Society for Vascular Surgery

Author

Kapila, Varun, Jetty, Prasad, Wooster, Doug, Vucemilo, Vic, and Dubois, Luc

Subjects
Medical societies -- Laws, regulations and rules, Abdominal aneurysm -- Diagnosis, Medical screening -- Laws, regulations and rules, Government regulation, Health, Health care industry
Abstract

Abdominal aortic aneurysms (AAAs) remain a major risk to patients, despite level 1 evidence for screening to prevent rupture events and decrease mortality. In 2007, the Canadian Society for Vascular Surgery (CSVS) published a review and position statement for AAA screening in Canada. Since that publication, there have been a number of updates in the published literature affecting screening recommendations. In this paper, we present a review of some of the controversies in the AAA screening literature to help elucidate differences in the various published screening guidelines. This article represents a review of the data and updated recommendations for AAA screening in the Canadian population on behalf of the CSVS. Les anevrismes de l'aorte abdominale (AAA) continuent de poser un risque majeur pour les patients, malgre des donnees probantes de niveau 1 a l'appui du depistage pour prevenir les ruptures et reduire la mortalite. En 2007, la Societe canadienne de chirurgie vasculaire (SCCV) a publie une revue et un enonce de position sur le depistage de l'AAA au Canada. Depuis lors, plusieurs mises a jour ont paru dans la litterature et elles ont un impact sur les recommandations relatives au depistage. Dans le present article, nous presentons une synthese de quelques controverses soulevees dans la litterature sur le depistage de l'AAA afin d'expliquer les differences entre les diverses lignes directrices publiees a ce sujet. Cet article propose au nom de la SCCV une revue des donnees probantes et des recommandations a jour sur le depistage de l'AAA dans la population canadienne., An abdominal aortic aneurysm (AAA) occurs when the abdominal aorta is more than 3 cm in maximal diameter, about 1.5 times larger than normal. The development of AAAs is associated [...]

Published
2021
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16. Variability in research productivity among Canadian surgical specialties

Author

Wang, Henry, Chu, Michael W.A., and Dubois, Luc

Subjects
Career development -- Evaluation, Medical journals -- Management, Journalism, Medical -- Management, Surgeons -- Practice, Company business management, Health, Health care industry
Abstract

Background: Academic productivity, as measured by number and impact of publications, is central to the career advancement and promotion of academic surgeons. We compared research productivity metrics among specialties and sought factors associated with increased productivity. Methods: Academic surgeons were identified through departmental webpages and their scholarly metrics were collected through Scopus in a standardized fashion. We collected total number of documents, h-index, and average number of publications per year in the preceding 5 years. We explored whether presence of a training program, graduate degree, academic rank and size of the clinical group affected productivity metrics. Linear regression was used for multivariable analysis. Results: We collected data on 2172 surgeons from 15 separate academic centres across Canada. Wide variability existed in metrics among specialties, with cardiac and neurosurgery being the most productive, and vascular surgery and plastic surgery being the least productive. The average number of publications was 71, and the average h-index was 18.7. The average h-index for cardiac surgery was 25.7 compared with 8.3 for vascular surgery (p < 0.001). Our multivariable model identified academic rank, surgical specialty, graduate degree, presence of a training program, and larger clinical group as being associated with increased academic productivity. Conclusion: There is variability in research productivity among Canadian surgical specialties. Cardiac surgery and neurosurgery are productive, whereas vascular surgery and plastic surgery are less productive than other surgical disciplines. Obtaining a research-oriented graduate degree, being part of a larger clinical group, and presence of a training program were all associated with higher productivity, even after adjusting for academic rank and specialty. Contexte : La productivité universitaire, évaluée selon le nombre de publications et leurs retombées, est déterminante pour la carrière et l'avancement des professeurs de chirurgie. Nous avons comparé des indicateurs de la productivité en recherche de diverses spécialités et cherché les facteurs liés à une productivité accrue. Méthodes : Nous avons identifié les professeurs de chirurgie dans les pages Web de départements, et recueilli dans Scopus, de manière normalisée, les données : nombre total de documents, indice h et nombre moyen de publications par année dans les 5 dernières années. Nous avons cherché à savoir si l'existence d'un programme de formation, le diplôme d'études supérieures, le rang professoral et la taille du groupe clinique avaient une incidence sur les indicateurs de productivité. L'analyse multivariable a été faite au moyen d'une régression linéaire. Résultats : Nous avons recueilli des données sur 2172 chirurgiens de 15 différents centres universitaires du Canada. Les indicateurs variaient grandement selon la spécialité. La productivité la plus élevée était associée à la chirurgie cardiaque et à la neurochirurgie, et la productivité la moins élevée, à la chirurgie vasculaire et à la chirurgie plastique. Le nombre moyen de publications était de 71 et l'indice h moyen, de 18,7. L'indice h moyen pour la chirurgie cardiaque était de 25,7, comparativement à 8,3 pour la chirurgie vasculaire (p < 0,001). Notre modèle multivariable a montré que le rang professoral, la spécialité chirurgicale, le diplôme d'études supérieures, l'existence d'un programme de formation et un grand groupe clinique sont liés à une productivité universitaire accrue. Conclusion : La productivité en recherche varie en fonction de la spécialité chirurgicale au Canada. La chirurgie cardiaque et la neurochirurgie sont productives, tandis que la chirurgie vasculaire et la chirurgie plastique le sont moins que d'autres spécialités. L'obtention d'un diplôme d'études supérieures axées sur la recherche, l'appartenance à un grand groupe clinique et l'existence d'un programme de formation étaient toutes associées à une productivité supérieure, même après correction pour tenir compte du rang professoral et de la spécialité., Academic surgeons must fulfill numerous professional obligations. In addition to the care of complex surgical patients, they are expected to mentor and train surgical residents and conduct research. Research output, [...]

Published
2021
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19. Mortality and major postoperative complications within one year after vascular surgery: a prospective cohort study

Author

Polok, Kamil, primary, Biccard, Bruce M., additional, Chan, Matthew T.V., additional, Archbold, R. Andrew, additional, Wang, Chew Yin, additional, Sigamani, Alben, additional, Urrútia, Gerard, additional, Cruz, Patricia, additional, Srinathan, Sadeesh K., additional, Szalay, David, additional, Harlock, John, additional, Tittley, Jacques G., additional, Elias, Fadi, additional, Jacka, Michael J., additional, Malaga, German, additional, Berwanger, Otavio, additional, Studzińska, Dorota, additional, Górka, Jacek, additional, Montes, Félix R., additional, Chow, Clara K., additional, Ackland, Gareth L., additional, Dubois, Luc, additional, Sapsford, Robert J., additional, Williams, Colin, additional, Cortés, Olga L., additional, Devereaux, P.J., additional, and Szczeklik, Wojciech, additional

Published
2024
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32. Hepatic artery aneurysm post remote pancreaticoduodenectomy.

Author

Djalal, Fakim, Landau, John, and Dubois, Luc

Subjects
HEPATIC artery, SAPHENOUS vein, MESENTERIC artery, COMPUTED tomography, FLUID flow
Abstract

We present a case of a 4.2-cm hepatic artery aneurysm following remote pancreaticoduodenectomy, which extended to the first division of the right hepatic artery. Given the absence of collateral flow from the superior mesenteric artery (SMA) and the inability to place a covered stent, we treated the patient with a saphenous vein graft to the right hepatic artery bifurcation. A CT scan at 1-year demonstrated a patent bypass to the right hepatic artery. We would advise caution when considering hepatic embolization following pancreaticoduodenectomy due to loss of SMA-based collaterals. Techniques that preserve arterial flow should be favored in this situation. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Management of transient ischemic attack or istroke related to extracranial internal carotid artery stenosis

Author

Kapila, Varun, Jetty, Prasad, Basile, Vincenzo S., and Dubois, Luc

Subjects
Arterial stenosis -- Care and treatment, Stroke -- Care and treatment, Transient ischemic attack -- Care and treatment, Death, Clopidogrel, Stenosis, Canadians, Atherosclerotic plaque, Ischemia, Morbidity, Antilipemic agents, Health
Abstract

Cerebrovascular disease is not only the third largest cause of death in Canada, it is also associated with substantial functional morbidity after an event. In 2013, over 400 000 Canadians [...]

Published
2019
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38. Outcomes After Neuraxial or Regional Anaesthesia Instead of General Anaesthesia for Lower Limb Revascularisation Surgery: A Systematic Review and Meta-Analysis of Randomised and Non-Randomised Studies

Author

Li, Allen, primary, Dreksler, Hannah, additional, Nagpal, Sudhir K., additional, Brandys, Timothy, additional, Jetty, Prasad, additional, Dubois, Luc, additional, Parsons Leigh, Jeanna, additional, Stelfox, Henry T., additional, McIsaac, Daniel I., additional, and Roberts, Derek J., additional

Published
2023
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39. Surveillance Strategies and Long-Term Scoping Review of Outcomes After Thoracic Endovascular Aortic Repair for Blunt Thoracic Aortic Injury

Author

Le, John Bao Phuc, Hussain, Ali, DuBose, Joseph, Roberts, Derek, Brenner, Megan L, Horer, Tal, Cagiannos, Catherine, Eimaan Khan, Dubois, Luc, Shorr, Risa, Nagpal, Sudhir, Jetty, Prasad, and Vincent, Remi

Subjects
Traumatic, Medtronic, Epidemiology, aortic arch, Thoracic, Medical Physiology, adverse event, FOS: Basic medicine, abdominal aorta, Injury, migration, patients, vascular surgery, adjunctive procedure, clinical, adjunctive, Medtronic Valiant, wound complication, stentgraft, stent fracture, stent induced new entry, freedom from mortality, thoracic aorta, left ventricular stiffening, LSA, dynes, follow-up, Medtronic Talent, RGAD, angiography, TEVAR, extension, aortobronchial fistula, gore, endograft, malapposition, Zenith, congestive heart failure, collapse, percutaneous, quality, Re-TEVAR, MVC, reinterventions, surveillance, access complication, Public Health, carotid-subclavian transposition, explantation, relining, zone 1 debranching, attrition, Gore TAG, computed tomography with contrast, endpoints, fall, carotid-subclavian bypass, non-invasive, technical success, wire, endoleak, Trauma, blunt, Cook Tx2, surveillance regimen, surgical, time intervals, aortoesophageal fistula, death, interventional radiology, case report, maldeployment, sentinel events, left subclavian artery revascularization, exclusion, infolding, secondary endpoints, loss to follow-up, CTA, evidence, young, Aortic, vascular access, adverse, pseudoaneurysm, computed tomography, prospective, mortality, radiology, SINE, open repair, young patients, pivotal trials, intraoperative conversion, Gore cTAG, Zenith Alpha, left ventricular remodelling, graft, Surgery, scoping review, Physiological Processes, aortic-related mortality, antegrade, Medical Sciences, reporting standards, data analysis, surveillance regimens, morbidity, retrograde, Analytical, Diagnostic and Therapeutic Techniques and Equipment, freedom from reintervention, Cardiovascular System, systematic review, vascular, fabric fatigue, Medical Specialties, Medicine and Health Sciences, magnetic resonance imaging, aortotracheal fistula, remodelling, EVAR, left subclavian artery, windkessel effect, thoracic endograft, loss to follow up, Aorta, proximal extension, bird-beaking, case series, stent-graft induced new entry, stroke, left ventricular hypertrophy, thoracic graft, MRA, endovascular, quadriplegia, revascularization, Anatomy, PTFE, FDA, MRI, distal extension, CT, open conversion, Critical Care, conflict of interest, cardiac, Other Medical Specialties, retrospective, LSAC, stenting, cerebrospinal fluid drainage, paralysis, thoracic endovascular aortic repair, paraplegia, paresis, cancer, follow up, stochastic, conversion, multi-organ failure, magnetic resonance angiography, in situ reconstruction, fabric tear, left subclavian artery coverage, adverse events, spinal cord injury, radiation, meta-analysis, nitinol, BTAI, retrograde aortic dissection, explant and extra-anatomic bypass, car crash, TAG, rupture, surgeon, stent, motor vehicle collision, Bolton Relay Pro, FDA-approved, neoplasm, malignancy
Abstract

A Scoping Review that aims to map the following objectives regarding Blunt Thoracic Aortic Injury (BTAI) patients treated with Thoracic Endovascular Repair (TEVAR) via appraisal of all forms of original literature published ≥2005: reporting details & rationale of surveillance strategies, along with congruence versus deviance of stated surveillance regimens with clinical practice guidelines; reporting details of follow-up, duration, loss to follow-up, & reasons for attrition; and reporting details of type & timing of adverse events & reinterventions peri- & post-TEVAR, in conjunction with implicated FDA-approved stent-graft designs. Additionally, quality control issues of the literature are heavily addressed via evaluation of variables’ reporting details.

Published
2023
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40. Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial

Author

Garg, Amit X., Devereaux, P.J., Hill, Andrew, Sood, Manish, Aggarwal, Bharat, Dubois, Luc, Hiremath, Swapnil, Guzman, Randolph, Iyer, Vikram, James, Matthew, McArthur, Eric, Moist, Louise, Ouellet, George, Parikh, Chirag R., Schumann, Virginia, Sharan, Sumit, Thiessen-Philbrook, Heather, Tobe, Sheldon, Wald, Ron, Walsh, Michael, Weir, Matthew, and Pannu, Neesh

Subjects
Curcumin -- Health aspects, Aneurysmectomy -- Methods -- Patient outcomes, Abdominal aortic aneurysm -- Development and progression -- Care and treatment, Health
Abstract

BACKGROUND: Curcumin, a popular herbal supplement from the plant turmeric, has prevented ischemic reperfusion and toxin-induced injury in many animal studies and a single-centre randomized human trial. We sought to test whether perioperative oral curcumin (compared with placebo) affects the inflammatory response and risk of postrepair complications after elective abdominal aortic aneurysm repair in humans. METHODS: We conducted a parallel-group, randomized, placebo-controlled trial of patients from 10 hospitals in Canada who were scheduled to undergo elective repair of an unruptured abdominal aortic aneurysm (November 2011 to November 2014). Patients in the treatment group received perioperative oral curcumin (2000-mg doses 8 times over 4 d). Patients, health care providers and local research staff were unaware of the treatment assignment. The primary outcomes were median concentrations of 4 biomarkers indicating injury and inflammation (postoperative urine interleukin-18 and perioperative rise in serum creatinine, plasma W-terminal pro-B-type natriuretic peptide and plasma high-sensitivity C-reactive protein). RESULTS: Baseline characteristics were similar in the 2 groups (606 patients overall; median age 76 yr). More than 85% of patients in each group took more than 80% of their scheduled capsules. Neither curcumin nor placebo significantly affected any of the 4 biomarkers (p > 0.05 for all comparisons). Regarding the secondary outcomes, there was a higher risk of acute kidney injury with curcumin than with placebo (17% v. 10%, p = 0.01), but no between-group difference in the median length of hospital stay (5 v. 5 days, p > 0.9) or the risk of clinical events (9% v. 9%, p = 0.9). INTERPRETATION: Curcumin had no beneficial effects when used in elective abdominal aortic aneurysm repair. These findings emphasize the importance of testing turmeric and curcumin before espousing their health benefits, as is currently done in the popular media. Trial registration: ClinicalTrials.gov, no. NCT01225094., Many modern medicines come from plants. (1,2) Turmeric, a plant in the ginger family that is native to South Asia, has been used for centuries as a spice and traditional [...]

Published
2018
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41. 2022 Canadian Surgery Forum Sept. 15–17, 202201. Operative classification of ventral abdominal hernias: new and practical classification02. Watchful waiting for large primary splenic cysts03. Transversus abdominis plane (TAP) blocks with and without dexamethasone in colorectal surgery04. What factors determine publication of resident research day projects?05. Characterization of near-infrared imaging and indocyanine green use amongst general surgeons06. Variation in opioid prescribing after outpatient breast surgery: Time for a streamlined approach?07. Trends in graduate degree types and research output for Canadian academic general surgeons08. Would you prefer to undergo breast-conserving therapy or a mastectomy for early breast cancer? Comparison of perceptions of general and plastic surgeons09. Lack of representation of women and BIPOC individuals in Canadian academic surgery10. Medical student interest and perspectives on pursuing surgical careers: a multicentre survey evaluating 5-year trends11. Difficult cholecystectomy with cholecystogastric fistula12. Surviving nonsurvivable injuries: patients who elude the “lethal” Abbreviated Injury Scale (AIS) score of six13. Gunshot wounds sustained during legal intervention v. those inflicted by civilians: a comparative analysis14. The impact of delayed time to first head CT on functional outcomes after blunt head trauma with moderately depressed GCS15. Contemporary utility of diagnostic peritoneal aspiration in trauma16. Impact of delayed time to first head CT in traumatic brain injury17. Radiologic predictors of in-hospital mortality after traumatic craniocervical dissociation18. Measurement properties of a patient-reported instrument to evaluate functional status after major surgery19. The safety of venous thromboembolism chemoprophylaxis use in endoscopic retrograde cholangiopancreatography20. Characterizing Canadian rural surgeons: trends over time and 10-year replacement needs21. Contextual interference for skills development and transfer in laparoscopic surgery: a randomized controlled trial22. Evaluating the accuracy and design of visual backgrounds in academic surgical journals23. Defining rural surgery in Canada24. Validity of video-based general and procedure-specific self-assessment tools for surgical trainees in laparoscopic cholecystectomy25. Examining the equity and diversity characteristics of academic general surgeons in Canada26. Video-based coaching for surgical residents: a systematic review and meta-analysis27. Very-low-energy diets prior to nonbariatric surgery: a systematic review and meta-analysis28. Factors associated with resident research success: a descriptive analysis of Canadian general surgery trainees29. Global surgery pilot curriculum in Canadian undergraduate medical education: a novel approach30. How useful is ultrasound in predicting surgical findings of “mild cholecystitis”?31. Implementing a colorectal surgery “virtual hospital”: description of a novel outpatient care pathway to advance surgical care32. Trends in training and workforce planning for Canadian pediatric surgeons: a 10-year model33. Patient perspectives on intraoperative blood transfusion: results of semistructured interviews with perioperative patients34. Understanding intraoperative transfusion decision-making variability: a qualitative study using the Theoretical Domains Framework35. Effectiveness of preoperative oscillating positive expiratory pressure (OPEP) therapy in reduction of postoperative respiratory morbidity in patients undergoing surgery: a systematic review37. Accuracy of point-of-care testing devices for hemoglobin in the operating room: a systematic review and meta-analysis38. Opioid-free analgesia after outpatient general surgery: a qualitative study focused on the perspectives of patients and clinicians involved in a pilot trial39. The impact of the COVID-19 pandemic on general surgery residency: an analysis of operative volumes by residents at a Canadian general surgery residency program40. Postoperative care protocols for elderly emergency surgical patients: a quality improvement initiative42. Adverse events following robotic compared to laparoscopic and open surgery: a population-based analysis43. Is accrual higher for patients randomized to pragmatic v. exploratory randomized clinical trials? A systematic review and meta-analysis44. Effect of preoperative proton-pump inhibitor use on postoperative infectious and renal complications after elective general surgery45. The early burden of COVID-19 in emergency general surgery care across Canada46. 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Delays in presentation and severity of illness predict adverse surgical outcomes among patients transferred from rural Indigenous communities for acute care surgery67. Remote video-based suturing education with smartphones (REVISE): a randomized controlled trial68. Modified Delphi consensus on appropriate use of laboratory investigations in acute care surgery patients72. Impacts of inpatient food at a tertiary care centre on patient satisfaction, nutrition and planetary health73. Racial disparities in health outcomes for oncological surgery in Canada75. Risk of recurrent laryngeal nerve injury from thyroidectomy is lower when intraoperative nerve monitoring (IONM) is used: an analysis of 17 688 patients from the NSQIP database01. The impact of the COVID-19 pandemic on non-smallcell lung cancer pathologic stage and presentation02. Screening criteria evaluation for expansion in pulmonary neoplasias (screen)03. Robotic-assisted lobectomy for early-stage lung cancer provides better patient-reported quality of life than video-assisted lobectomy: early results of the RAVAL trial04. Breathe Anew: designing and testing the feasibility of a novel intervention for lung cancer survivorship05. Learning objectives for thoracic surgery: developing a national standard for undergraduate medical education06. Plasma cell-free DNA as a point-of-care well-being biomarker for early-stage non-small-cell lung cancer patients07. Sarcopenia determined by skeletal muscle index predicts overall survival, disease-free survival and postoperative complications in resectable esophageal cancer: a systematic review and meta-analysis08. The short- and long-term effects of open v. minimally invasive thymectomy in myasthenia gravis patients: a systematic review and meta-analysis09. Optimizing opioid prescribing practices following minimally invasive lung resections through a structured quality improvement process10. Effects of virtual postoperative postdischarge care in patients undergoing lung resection during the COVID-19 pandemic11. Initiating Ethiopia’s first minimally invasive surgery program: a novel approach for collaborations in global surgical education12. Patient outcomes following salvage lung cancer surgery after definitive chemotherapy or radiation13. Replacing chest X-rays after chest tube removal with clinical assessment in postoperative thoracic surgery patients14. Updating the practice of thoracic surgery in Canada: a survey of the Canadian Association of Thoracic Surgeons15. The impact of COVID-19 on the diagnosis and treatment of lung cancer16. Development of a prediction model for survival time in esophageal cancer patients treated with resection17. The development and validation of a mixed reality thoracic surgical anatomy atlas18. Routine placement of feeding tubes should be avoided in esophageal cancer patients undergoing surgery19. Nodal count is no different during robotic segmentectomy compared with robotic lobectomy20. Point-of-care ultrasound-guided percutaneous biopsy of solid masses in the thoracic outpatient clinic: a safe, high-yield procedure to accelerate tissue diagnosis for patients with advanced thoracic malignancy21. Sarcopenia and modified frailty index are not associated with adverse outcomes after esophagectomy for esophageal cancer: a retrospective cohort study22. Near-infrared-guided segmental resection for lung cancer: an analysis of the learning curve23. Routine use of feeding jejunostomy tubes in patients undergoing esophagectomy for esophageal malignancy is safe and associated with low complication rates01. Ghost ileostomy versus loop ileostomy following total mesorectal excision for rectal cancer: a systematic review and meta-analysis02. Analysis of 100 consecutive colorectal cancers presenting at a Canadian tertiary care centre: delayed diagnosis and advanced disease03. 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Oncological outcomes after colorectal cancer in patients with liver cirrhosis: a systematic review and meta-analysis24. Optimal preoperative nutrition for penetrating Crohn disease: a systematic review and meta-analysis25. Lymph node ratio as a predictor of survival for colon cancer: a systematic review and meta-analysis26. Barriers and facilitators for use of new recommendations for optimal endoscopic localization of colorectal neoplasms according to gastroenterologists and surgeons27. Emergency colorectal surgery in patients with cirrhosis: a population-based descriptive study28. Local recurrence rates and associated risk factors after transanal endoscopic microsurgery for benign polyps and adenocarcinomas29. Bowel dysfunction impacts mental health after restorative proctectomy for rectal cancer30. Evolution of psychological morbidity following restorative proctectomy for rectal cancer: a systematic review and meta-analysis31. Frailty predicts LARS and quality of life in rectal cancer survivors after restorative proctectomy32. Low anterior resection syndrome in a reference North American population: prevalence and predictive factors33. The evolution of enhanced recovery: same day discharge after laparoscopic colectomy34. Effect of ERAS protocols on length of stay after colorectal surgery: an interrupted time series analysis35. Practice patterns and outcomes in individuals with cirrhosis and colorectal cancer: a population-based study36. Understanding the impact of bowel function on quality of life after rectal cancer surgery37. Right-sided colectomies for diverticulitis have worse outcomes compared with left-sided colectomies38. Symptom burden and time from symptom onset to cancer diagnosis in patients with early-onset colorectal cancer39. The impact of access to robotic rectal surgery at a tertiary care centre: a Canadian perspective40. 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Externally benchmarking colorectal resection outcomes in our province against the ACS NSQIP risk calculator: identifying opportunities for improvement57. Externally benchmarking our provincial colectomy outcomes against the ACS NSQIP using the Codman Score: to identify possible opportunities for improvement of outcomes58. Rural v. urban documentation of recommended practices for optimal endoscopic colorectal lesion localization01. Incidence of in-hospital opioid use and pain after inguinal hernia repair02. Ventral hernia repair following liver transplantation: outcome of repair techniques and risk factors for recurrence01. Impact of the COVID-19 pandemic on bariatric surgery in North America: a retrospective analysis of 834 647 patients02. Patient selection and 30-day outcomes of SADI-S compared to RYGB: a retrospective cohort study of 47 375 patients03. New persistent opioid use following bariatric surgery: a systematic review and pooled proportion meta-analysis04. Bariatric surgery should be offered to active-duty military personnel: a retrospective study of the Canadian Armed Forces experience05. Opioid prescribing practices and use following bariatric surgery: a systematic review and pooled summary of data06. Sacred sharing circles: urban Indigenous Manitobans’ experiences with bariatric surgery07. Gastrogastric hernia after laparoscopic gastric great curve plication: a video presentation08. Characterization of comorbidities predictive of bariatric surgery09. Efficacy of preoperative high-dose liraglutide in patients with superobesity10. The effect of linear stapled gastrojejunostomy size in Roux-en-Y gastric bypass11. Fragility of statistically significant outcomes in randomized trials comparing bariatric surgeries12. Weight loss outcomes for patients undergoing conversion to Roux-en-Y gastric bypass after sleeve gastrectomy13. Are long waiting lists for bariatric surgery detrimental to patients? A single-centre experience14. 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Omission of axillary staging and survival in elderly women with early-stage breast cancer: a population-based cohort study05. Patients’ experiences receiving cancer surgery during the COVID-19 pandemic: a qualitative study06. Cancer surgery outcomes are better at high-volume centres07. Attitudes of Canadian colorectal cancer care providers toward liver transplantation for colorectal liver metastases: a national survey08. Quality of narrative central and lateral neck dissection reports for thyroid cancer treatment suggests need for a national standardized synoptic operative template09. Transoral endoscopic thyroidectomy vestibular approach (TOETVA): indications and technique10. Temporal trends in lymph node assessment as a quality indicator in colorectal cancer patients treated at a high-volume Canadian centre11. Molecular landscape of early-stage breast cancer with nodal metastasis12. 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MOLLI for excision of nonpalpable breast lesions: a case series22. Patients awaiting mastectomy report increased depression, anxiety, and decreased quality of life compared with patients awaiting lumpectomy for treatment of breast cancer23. Is microscopic margin status important in retroperitoneal sarcoma (RPS) resection? A systematic review and meta-analysis24. Absence of benefit of routine surveillance in very-low-risk and low-risk gastric gastrointestinal stromal tumors25. Effect of intraoperative in-room specimen radiography on margin status in breast-conserving surgery26. Active surveillance for DCIS of the breast: qualitative interviews with patients and physicians01 Outcomes following extrahepatic and intraportal pancreatic islet transplantation: a comparative cohort study02. Cholang-funga-gitis03. Evaluating the effect of a low-calorie prehepatectomy diet on perioperative outcomes: a systematic review and meta-analysis04. 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Development of a culture process to grow a full-liver tissue substitute12. Liver transplantation for fibrolamellar hepatocellular carcinoma: an analysis of the European Liver Transplant Registry13. Arming beneficial viruses to treat pancreatic cancer14. Hepaticoduodenostomy versus hepaticojenunostomy for biliary reconstruction: a retrospective review of a single-centre experience15. Feasibility and safety of a “shared care” model in complex hepatopancreatobiliary surgery: a 5-year analysis of pancreaticoduodenectomy16. Laparoscopic v. open pancreaticoduodenectomy: initial institutional experience and NSQIP-matched analysis17. Laparoscopic spleen-preserving distal pancreatectomy: Why not do a Warshaw?18. The impact of COVID-19 on pancreaticoduodenectomy outcomes in a high-volume hepatopancreatobiliary centre19. Transitioning from open to minimally invasive pancreaticoduodenectomy: the learning curve factor in an academic centre20. Closed-incision negative-pressure wound therapy following pancreaticoduodenectomy for prevention of surgical site infections in high-risk patients21. Robotic Appleby procedure for recurrent pancreatic cancer22. The influence of viral hepatitis status on posthepatectomy complications in patients with hepatocellular carcinoma: a NSQIP analysis

Author

Selim, Yasser, primary, Di Lena, Élise, primary, Abu-Omar, Nawaf, primary, Baig, Zarrukh, primary, Verhoeff, Kevin, primary, La, Julie, primary, Purich, Kieran, primary, Albacete, Samantha, primary, Valji, Rahim, primary, Safar, Ali, primary, Schellenberg, Morgan, primary, Daza, Julian, primary, Glass, Lyndsay T., primary, Johnson, Garrett, primary, Guidolin, Keegan, primary, Balvardi, Saba, primary, Gawad, Nada, primary, McKechnie, Tyler, primary, Henley, Jessica, primary, Imbert, Emma, primary, Li, Christine, primary, Skinner, Samuel, primary, Lenet, Tori, primary, Metz, Jeff, primary, Ahn, Hilalion (San), primary, Do, Uyen, primary, Rouhi, Armin, primary, Greenberg, Brianna, primary, Muaddi, Hala, primary, Park, Lily, primary, Vogt, Kelly, primary, Bradley, Nori, primary, Deng, Shirley Xiaoxuan, primary, Murphy, Patrick, primary, Alhabboubi, Mostafa, primary, Lie, Jessica, primary, Laplante, Simon, primary, Drung, Jeremy, primary, Nixon, Thomas, primary, Allard-Coutu, Alexandra, primary, Mansouri, Sarah, primary, Lee, Alex, primary, Tweedy, Jillian, primary, D’Elia, Michael A., primary, Hopkins, Brent, primary, Srivastava, Ananya, primary, Alibhai, Kameela, primary, Lee, Christina, primary, Moon, Jeongyoon (Jenny), primary, How, Nathan, primary, Spoyalo, Karina, primary, Lalande, Annie, primary, Schweitzer, Christina, primary, Keogh, Joshua, primary, Huo, Bright, primary, Patel, Yogita S., primary, Jogiat, Uzair, primary, McGuire, Anna L., primary, Lee, Yung, primary, Barber, Evan, primary, Akhtar-Danesh, Gileh-Gol, primary, Bondzi-Simpson, Adom, primary, Bowker, Riley, primary, Ahmadi, Negar, primary, Abdul, Sami A., primary, Patel, Pooja, primary, Harrison, Lyndsay, primary, Shi, Ge, primary, Alaichi, Jacob A., primary, Kidane, Biniam, primary, Qu, Linda Chang, primary, Alaichi, Jacob, primary, Mackay, Emily, primary, Lee, Jay, primary, Castelo, Matthew, primary, Caycedo-Marulanda, Antonio, primary, Brennan, Kelly, primary, Garfinkle, Richard, primary, Sharma, Sahil, primary, Candy, Sydney, primary, Lee, Lawrence, primary, Robitaille, Stephan, primary, Sadri, Hamid, primary, Selznick, Sydney, primary, Wiseman, Vanessa, primary, Baker, Laura, primary, Ichhpuniani, Simarpreet, primary, Zhang, Lisa, primary, Holden, James, primary, Paradis, Tiffany, primary, Bayat, Zubair, primary, Patel, Sunil, primary, Maalouf, Michael Fares, primary, Wachtel, Alon, primary, Baronas, Victoria, primary, Hajjar, Roy, primary, Ehlebracht, Alexa, primary, Caminsky, Natasha, primary, Gilbert, Richard, primary, Morin, Geneviève, primary, Auer, Rebecca C., primary, Phang, Terry, primary, Hopkins, Jessica, primary, Levin, Yosef, primary, Alam, Armaghan, primary, Lagace, Philip, primary, El-Kefraoui, Charbel, primary, Mainprize, Marguerite, primary, Melland-Smith, Megan, primary, Nasser, Khadija, primary, Mailloux, Olivier, primary, Whyte, Marta, primary, Li, Ting, primary, Ahmad, Mirza Shaharyar, primary, Sun, Warren, primary, Roach, Eileen, primary, Chow, Alexandra, primary, Trac, Jessica, primary, He, Wenjing, primary, Ramji, Karim, primary, Kouzmina, Ekaterina, primary, Koziak, Cypriana, primary, Hossain, Intekhab, primary, Mocanu, Valentin, primary, Hanna, Nader, primary, Pook, Makena, primary, Zuckerman, Jesse, primary, Choi, Woo Jin, primary, Watanabe, Akie, primary, Saravana-Bawan, Bianka, primary, Cyr, David, primary, Brackstone, Muriel, primary, Ivankovic, Victoria, primary, Nair, Ananya Gopika, primary, Hirpara, Dhruvin, primary, Stockley, Cecily, primary, Ng, Deanna, primary, Luu, Shelly, primary, Meloche-Dumas, Léamarie, primary, Eom, Ashley, primary, Tang, Katelynn, primary, Khan, Shawn, primary, Schmitz, Erika, primary, Chen, Ko Ta, primary, Newman-Bremang, Jieun, primary, Jette, Nic, primary, Mir, Zuhaib, primary, Griffiths, Christopher, primary, Rajendran, Luckshi, primary, Amhis, Nawal, primary, Claasen, Marco, primary, Workewych, Adriana, primary, Waugh, Evelyn, primary, Zhu, Alice, primary, Nabavian, Helia, primary, Roldan, Jorge, primary, Lagrotteria, Andrew, primary, Safa, Nadia, additional, Rahman, Sid, additional, Kaneva, Pepa, additional, Feldman, Liane, additional, Baig, Zarrukh, additional, Ginther, Nathan, additional, Gill, Dilip, additional, Sarwar, Zaini, additional, Verdiales, Carlos, additional, Moser, Mike, additional, Mocanu, Valentin, additional, Fang, Breanna, additional, Dang, Jerry, additional, Sun, Warren, additional, Switzer, Noah, additional, Birch, Daniel, additional, Karmali, Shahzeer, additional, Alqaydi, Anood, additional, Wei, Xuejiao, additional, Digby, Genevieve, additional, Brogly, Susan, additional, Merchant, Shaila, additional, Verhoeff, Kevin, additional, Miles, Alexander, additional, Kung, Janice Y., additional, Shapiro, A.M. James, additional, Bigam, David L., additional, Matkin, Ashlee, additional, Dumestre, Danielle, additional, Peiris, Lashan, additional, Turner, Simon, additional, Mador, Brett, additional, McLennan, Steffane, additional, Jastaniah, Atif, additional, Owattanapanich, Natthida, additional, Grigorian, Areg, additional, Lam, Lydia, additional, Nahmias, Jeffry, additional, Inaba, Kenji, additional, Liasidis, Panagiotis, additional, Demetriades, Demetrios, additional, Benjamin, Elizabeth R., additional, Cowan, Shaun, additional, Wong, Monica D., additional, Emigh, Brent, additional, Karavites, Lindsey, additional, Clark, Damon H., additional, Anderson, Geoffrey A., additional, Cheng, Vincent, additional, Myers, Lee, additional, Cuthbertson, Brian, additional, Myles, Paul, additional, Shulman, Mark, additional, Wijeysundera, Duminda, additional, Murphy, Patrick B., additional, Allen, Laura, additional, Minkhorst, Kathryn, additional, Bowker, Dillon, additional, Tang, Ephraim S., additional, Leslie, Kenneth, additional, Hawel, Jeffrey E., additional, Ma, Odelle, additional, Purich, Kieran, additional, Skinner, Samuel, additional, Dhaliwal, Raveena, additional, Strickland, Matt, additional, Park, Jason, additional, Vergis, Ashley, additional, Gillman, Lawrence, additional, Rivard, Justin, additional, Lin, Justin, additional, Zorigtbaatar, Anudari, additional, Nadeem, Minahil, additional, Ibrahim, Tarek, additional, Neilson, Zdenka, additional, Kim, Kyung Young (Peter), additional, Rajendran, Luckshi, additional, Chadi, Sami, additional, Quereshy, Fayez, additional, Davidson, Malcolm, additional, Friedrich, Emily, additional, Champion, Caitlin, additional, Semsar-Kazerooni, Koorosh, additional, Mueller, Carmen, additional, Vassiliou, Melina, additional, Al Mahroos, Mohammed, additional, Fiore, Julio, additional, Schwartzman, Kevin, additional, Anderson, Blaire, additional, Daniel, Ryan, additional, Kruse, Colin, additional, Levin, Marc, additional, Lee, Yung, additional, Doumouras, Aristithes, additional, Hong, Dennis, additional, Eskicioglu, Cagla, additional, Povolo, Christopher, additional, Lee, Jay, additional, Park, Lily, additional, Bhandari, Mohit, additional, Lee, Esther, additional, Sydora, Dasan, additional, Boone, Darrell, additional, Roberts, Stephanie, additional, McGrouther, Duncan, additional, Manuel, Paul, additional, Dykstra, Mark, additional, Wang, Haili, additional, Snelgrove, Ryan, additional, Perry, Troy, additional, Strickland, Matthew, additional, Skanes, Stephanie, additional, Tropiano, Joseph, additional, McIsaac, Daniel, additional, Tinmouth, Alan, additional, Hallet, Julie, additional, Nicholls, Stuart, additional, Fergusson, Dean, additional, Martel, Guillaume, additional, Ivankovic, Victoria, additional, Patey, Andrea, additional, Naqvi, Reza, additional, Noppens, Ruediger, additional, Hawel, Jeff, additional, Elnahas, Ahmad, additional, Schlachta, Christopher, additional, Alkhamesi, Nawar, additional, Lenet, Tori, additional, Gilbert, Richard, additional, Mallick, Ranjeeta, additional, Shaw, Julie, additional, Pook, Makena, additional, Najafi, Tahereh, additional, Rajabiyazdi, Fateme, additional, El-Kefraoui, Charbel, additional, Balvardi, Saba, additional, Barone, Natasha, additional, Elhaj, Hiba, additional, Nguyen-Powanda, Philip, additional, Lee, Lawrence, additional, Baldini, Gabriele, additional, Jogiat, Uzair, additional, Mapiour, Deng, additional, Kim, Michael, additional, Nadler, Ashlie, additional, Stukel, Theres, additional, De Mestral, Charles, additional, Nathens, Avery, additional, Pautler, Stephen, additional, Shayegan, Bobby, additional, Hanna, Wael, additional, Breau, Rodney, additional, Hopkins, Laura, additional, Jackson, Timothy, additional, Karanicolas, Paul, additional, Griffiths, Christopher, additional, Ali, Sam, additional, Archer, Victoria, additional, Cloutier, Zacharie, additional, Choi, Dexter, additional, McKechnie, Tyler, additional, Serrano, Pablo, additional, McClure, J. Andrew, additional, Jones, Philip, additional, Mrkobrada, Marko, additional, Flier, Suzanne, additional, Welk, Blayne, additional, Dubois, Luc, additional, Khwaja, Kosar, additional, Tung, Lily, additional, Hameed, Morad, additional, Spoyalo, Karina, additional, Lampron, Jacinthe, additional, Garcia-Ochoa, Carlos, additional, Engels, Paul, additional, Talwar, Gaurav, additional, Minor, Sam, additional, Moffat, Brad, additional, Parry, Neil, additional, Vogt, Kelly, additional, Ebeye, Tega, additional, Sharma, Bree T., additional, Samman, Anas, additional, Zulfiqar, Amna, additional, Purzner, Roderick H., additional, Greene, Brittany, additional, Tsang, Melanie, additional, Jayaraman, Shiva, additional, Ball, Chad G., additional, Nenshi, Rahima, additional, Widder, Sandy, additional, Bradley, Nori, additional, Liberman, Sender, additional, Wong, Evan, additional, Chughtai, Talat, additional, Turner, Joel, additional, Wiseman, Sam, additional, Li, Jennifer, additional, Mak, Nicole, additional, Namazi, Babak, additional, Kiani, Parmiss, additional, Hashimoto, Daniel, additional, Alseidi, Adnan, additional, Pasten, Mauricio, additional, Brunt, L. Michael, additional, Gill, Sujata, additional, Davis, Brian, additional, Bloom, Matthew, additional, Pernar, Luise, additional, Okrainec, Allan, additional, Madani, Amin, additional, Hamilton, Trevor, additional, Nabata, Kylie, additional, Zhang, Jenny W., additional, Zhao, Darren, additional, Dawe, Phil, additional, Leslie, Ken, additional, Drung, Jeremy, additional, Heller, Barbara, additional, Wright, Victoria, additional, Cho, Wanjae, additional, Wong, Michael, additional, Singh, Kevin, additional, Comeau, Émilie, additional, Collin, Yves, additional, Oviedo, Sonia Cheng, additional, Lamb, Tyler, additional, Reid, Morgann, additional, Turner, Anastasia, additional, Bertens, Kimberly, additional, Rekman, Janelle, additional, Balaa, Fady, additional, Neumann, Katerina, additional, Porter, Geoff, additional, Teo, Iris, additional, Forse, Catherine L., additional, Musselman, Reilly, additional, Grozman, Lily, additional, Alshawan, Nawaf, additional, Fraser, Shannon, additional, 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Sender, additional, Feinberg, Stan, additional, Hayden, Dana M., additional, Chadi, Sami A., additional, Demyttenaere, Sebastian, additional, Samuel, Louise, additional, Hotakorzian, Nevart, additional, Quintin, Laurence, additional, Morin, Nancy, additional, Ghitulescu, Gabriela, additional, Faria, Julio, additional, Vasilevsky, Carol-Ann, additional, Boutros, Marylise, additional, Mckechnie, Tyler, additional, Khamar, Jigish, additional, Ichhpuniani, Simarpreet, additional, Govind, Shaylan, additional, Lu, Justin, additional, Cardenas, Luisa, additional, Schep, Daniel, additional, Wong, Raimond, additional, Levine, Oren, additional, Stein, Barry, additional, Charlebois, Patrick, additional, Fried, Gerald, additional, Wang, Anna, additional, Fiore, Julio F., additional, Barkun, Alan, additional, Levy, Jordan, additional, Bogdan, Ruxandra, additional, Hawel, Jeffrey, additional, Alkhamesi, Nawar A., additional, Schlachta, Christopher M., additional, Iaboni, Natasha, additional, Hurlbut, David, additional, Kaufmann, Martin, additional, Ren, Kevin Yi Mi, additional, Jamzad, Amoon, additional, Mousavi, Parvin, additional, Fichtinger, Gabor, additional, Nicol, Christopher J.B., additional, Rudan, John F., additional, Brennan, Kelly, additional, Patel, Sunil V., additional, Booth, Chris, additional, Huo, Bright, additional, Donaldson, Alexandra, additional, Murthy, Sanjay, additional, Biro, Jeremy, additional, Singh, Harminder, additional, Helewa, Ramzi, additional, Reynolds, Kristin, additional, Sibley, Kathryn, additional, Doupe, Malcolm, additional, Johnson, Garrett, additional, Hochman, David, additional, Garfinkle, Richard, additional, Dell’Aniello, Sophie, additional, Zelkowitz, Phyllis, additional, Brassard, Paul, additional, Zoughlami, Amine, additional, Abibula, Wusiman, additional, Amar, Alex, additional, Araji, Théa, additional, Pang, Allison, additional, Ehlebracht, Alexa, additional, Robitaille, Stephan, additional, Oliver, Mahalia, additional, Feldman, Liane S., additional, Kennedy, Erin, additional, Victor, Charles, additional, Govindarajan, Anand, additional, Merchant, Shaila J., additional, Penta, Ruxandra, additional, Fiore, Julio Flavio, additional, Wong-Chong, Nathalie, additional, Marinescu, Daniel, additional, Bhatnagar, Sahir, additional, Arif, Arif, additional, Ladua, Gale, additional, Bhang, Eric, additional, Donellan, Fergal, additional, Stuart, Heather, additional, Loree, Jonathan, additional, MacDonald, Peter Hugh, additional, Barnett, Kathleen Wattie, additional, Ghuman, Amandeep, additional, Yoon, Hyea Min, additional, Fragoso, Gabriela, additional, Oliero, Manon, additional, Calvé, Annie, additional, Rendos, Hervé Vennin, additional, Gonzalez, Emmanuel, additional, Brereton, Nicholas J.B., additional, Cuisiniere, Thibault, additional, Gerkins, Claire, additional, Djediai, Souad, additional, Annabi, Borhane, additional, Diop, Khoudia, additional, Routy, Bertrand, additional, Laplante, Patrick, additional, 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additional, Maclellan, Steven, additional, Trottier, Daniel, additional, Jonker, Derek, additional, Asmis, Timothy, additional, Ramsay, Timothy, additional, Carrier, Marc, additional, Shojaei, Delaram, additional, Motamedi, Ali, additional, Ghuman, Anu, additional, Buie, Don, additional, Al Busaidi, Nasra, additional, Udwadia, Farhad, additional, McFadden, Nathalie, additional, Spence, Richard, additional, Hirsch, Greg, additional, Yilbas, Ayse, additional, Netto, Fernando Spencer, additional, Katz, Joel, additional, Sharma, Bree, additional, Khan, Usman, additional, Selzner, Markus, additional, Wilson, Hillary, additional, Forbes, Hayley, additional, Kung, Janice, additional, Tassé, Nicolas, additional, Tchernof, André, additional, Nadeau, Mélanie, additional, Dawe, Philip, additional, Beckett, Andrew, additional, Biertho, Laurent, additional, Lin, Andrea, additional, Birch, Daniel W., additional, Switzer, Noah J., additional, Fowler-Woods, Melinda, additional, Fowler-Woods, Amanda, additional, Shingoose, Geraldine, additional, Hatala, Andrew, additional, Daeninck, Felicia, additional, Hardy, Krista, additional, Clouston, Kathleen, additional, Debru, Estifanos, additional, De Gara, Christopher, additional, Halasz, Jennifer, additional, Kanji, Aliyah, additional, Modi, Renuca, additional, Gu, Jeffrey, additional, Jarrar, Amer, additional, Kolozsvari, Nicole, additional, Chen, Lucy, additional, Hapugall, Akithma, additional, Javidan, Arshia, additional, Laplante, Simon, additional, Stogryn, Shannon, additional, Maeda, Azusa, additional, Balas, Michael, additional, Gee, Denise, additional, Hutter, Matthew, additional, Meireles, Ozanan, additional, Boudreau, Vanessa, additional, Anvari, Mehran, additional, Iranmanesh, Pouya, additional, Barlow, Karen, additional, Cookson, Tyler, additional, Bolis, Rafik, additional, Shanthanna, Harsha, additional, Shiroky, Jonah, additional, Deghan, Shaidah, additional, Zevin, Boris, additional, Brodie, Jane, additional, O’Brien, Erin, additional, Tedman-Aucoin, Katherine, additional, Lawlor, Diana, additional, Murphy, Raleen, additional, Twells, Laurie, additional, Pace, David, additional, Ellsmere, James, additional, Evans, Bradley, additional, Zhang, Terry, additional, Deehan, Edward, additional, Kao, Dina, additional, Hotte, Naomi, additional, Samarasinghe, Kalutota, additional, Walter, Jens, additional, Madsen, Karen, additional, Williams, Erin, additional, Fundytus, Adam, additional, Chung, Wiley, additional, Ghezeljeh, Tahereh Najafi, additional, Lapointe-Gagner, Maxime, additional, Sutradhar, Rinku, additional, Haas, Barbara, additional, Guttman, Matthew, additional, Eskander, Antoine, additional, Chesney, Tyler, additional, Tillman, Bourke, additional, Zuk, Victoria, additional, Chan, Wing, additional, Guidolin, Keegan, additional, Servidio-Italiano, Filomena, additional, Sapisochin, Gonzalo, additional, Prisman, Eitan, additional, Mitmaker, Elliot, additional, Walker, Ross, additional, Wu, Jonn, additional, Nguyen, Anne, additional, Gupta, Michael, additional, Pasternak, Jesse, additional, Vergara-Fernandez, Omar, additional, Brar, Amanpreet, additional, Conner, James, additional, Kirsch, Richard, additional, Brar, Mantaj, additional, Gryfe, Robert, additional, MacRae, Helen, additional, Cohen, Zane, additional, McLeod, Robin, additional, Swallow, Carol, additional, Ghasemi, Farhad, additional, Delisle, Megan, additional, Stacey, Dawn, additional, Abou-Khalil, Jad, additional, Dingley, Brittney, additional, McAlpine, Kristen, additional, Nessim, Carolyn, additional, Tadros, Shaheer, additional, Auer, Rebecca, additional, Lim, David, additional, Pickard, Felicia, additional, Mathieson, Alexander, additional, Hogan, Michael, additional, Seal, Melanie, additional, Acidi, Belkacem, additional, Johnston, Wendy, additional, Callegaro, Dario, additional, Brar, Savtaj, additional, Gladdy, Rebecca, additional, Chung, Peter, additional, Catton, Charles, additional, Khalili, Korosh, additional, Honore, Charles, additional, Fu, Ning, additional, Kazazian, Karineh, additional, Pacholczyk, Karina, additional, Ng, Deanna, additional, Swett-Cosentino, Jossie, additional, Savage, Paul, additional, Shibahara, Yukiko, additional, Kalimuthu, Sangeetha, additional, Espin-Garcia, Osvaldo, additional, Yeung, Jonathan, additional, Mercier, Frédéric, additional, Barabash, Victoria, additional, Law, Calvin, additional, Singh, Simron, additional, Myrehaug, Sten, additional, Auer, Rebecca C., additional, Muhn, Narry, additional, Lovrics, Peter, additional, Koerber, Daniel, additional, Al-Sukhni, Eisar, additional, Cyr, David, additional, Apte, Sameer, additional, Ban, Judy, additional, Chen, Leo, additional, McKevitt, Elaine, additional, Warburton, Rebecca, additional, Pao, Jin-Si, additional, Dingee, Carol, additional, Kuusk, Urve, additional, Bazzarelli, Amy, additional, Hong, Nicole Look, additional, Gagliardi, Anna, additional, Nyhof, Bryanna, additional, Marfil-Garza, Braulio, additional, Sandha, Gurpal, additional, Cooper, David, additional, Dajani, Khaled, additional, Bigam, David, additional, Kin, Tatsuya, additional, Lam, Anna, additional, O’Gorman, Doug, additional, Senior, Peter, additional, Ricordi, Camillo, additional, Moser, Michael, additional, Lam, Henry, additional, Jalink, Diederick, additional, Bennett, Sean, additional, Zhang, Betty, additional, Tywonek, Kasia, additional, Meyers, Brandon, additional, Shorr, Risa, additional, Wei, Alice, additional, Kaliwal, Yosuf, additional, Williams, Phil, additional, Claasen, Marco, additional, Ivanics, Tommy, additional, Englesakis, Marina, additional, Gallinger, Steven, additional, Brind’Amour, Alexandre, additional, Toso, Christian, additional, Adam, Rene, additional, Ijzermans, Jan, additional, Polak, Wojtek, additional, Léveillé, Maxime, additional, Lawson, Christine, additional, Tai, Lee-Hwa, additional, Al-Arnawoot, Ahmed, additional, Mimeault, Richard, additional, Zhang, Chris, additional, Lemke, Madeline, additional, Glinka, Juan, additional, Skaro, Anton, additional, Tang, Ephraim, additional, Bubis, Lev, additional, Tsang, Melanie E., additional, Ganescu, Olivia, additional, Pelletier, Jean-Sébastien, additional, Choi, Woo Jin, additional, Muaddi, Hala, additional, and Classen, Marco P.A.W., additional

Published
2022
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45. Myocardial Injury After Noncardiac Surgery (MINS) in Vascular Surgical Patients: A Prospective Observational Cohort Study

Author

Biccard, Bruce M., Scott, David Julian Ashbridge, Chan, Matthew T. V., Archbold, Andrew, Wang, Chew-Yin, Sigamani, Alben, Urrútia, Gerard, Cruz, Patricia, Srinathan, Sadeesh K., Szalay, David, Harlock, John, Tittley, Jacques G., Rapanos, Theodore, Elias, Fadi, Jacka, Michael J., Malaga, German, Abraham, Valsa, Berwanger, Otavio, Montes, Félix R., Heels-Ansdell, Diane M., Hutcherson, Matthew T., Chow, Clara K., Polanczyk, Carisi A., Szczeklik, Wojciech, Ackland, Gareth L., Dubois, Luc, Sapsford, Robert J., Williams, Colin, Cortés, Olga L., Le Mananch, Yannick, and Devereaux, P. J.

Published
2018
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47. Teaching surgery takes time: the impact of surgical education on time in the operating room

Author

Vinden, Christopher, Malthaner, Richard, McGee, Jacob, McClure, J. Andrew, Winick-Ng, Jennifer, Liu, Kuan, Nash, Danielle M., Welk, Blayne, and Dubois, Luc

Subjects
Medical personnel training -- Evaluation, Surgery -- Standards, Medical education -- Comparative analysis, Patient care -- Standards, Health, Health care industry
Abstract

Background: It is generally accepted that surgical training is associated with increased surgical duration. The purpose of this study was to determine the magnitude of this increase for common surgical [...]

Published
2016
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48. Association between day of the week of elective surgery and postoperative mortality

Author

Dubois, Luc, Vogt, Kelly, Vinden, Chris, Winick-Ng, Jennifer, McClure, J. Andrew, Roshanov, Pavel S., Bell, Chaim M., and Garg, Amit X.

Subjects
Mortality -- Analysis -- Canada, Elective surgery -- Research -- Patient outcomes, Health
Abstract

BACKGROUND: In prior studies, higher mortality was observed among patients who had elective surgery on a Friday rather than earlier in the week. We investigated whether mortality after elective surgery was associated with day of the week of surgery in a Canadian population and whether the association was influenced by surgeon experience and volume. METHODS: We conducted a population-based retrospective cohort study in the province of Ontario, Canada. We included adults who underwent 1 of 12 elective daytime surgical procedures from Apr. 1, 2002, to Dec. 31, 2012. The primary outcome was 30-day mortality. We used generalized estimating equations to compare outcomes for surgeries performed on different days of the week, adjusting for patient and surgeon factors. RESULTS: A total of 402899 procedures performed by 1691 surgeons met our inclusion criteria. The median length of hospital stay was 6 (interquartile range 5-8) days. Surgeon experience varied significantly by day of week (p < 0.001), with surgeons operating on Fridays having the least experience. Nearly all of the patients who had their procedure on a Friday had postoperative care on the weekend, as compared with 49.1% of those whose surgery was on a Monday (p < 0.001). We found no difference in the 30-day mortality between procedures performed on Fridays and those performed on Mondays (adjusted odds ratio 1.08, 95% confidence interval 0.97-1.21). INTERPRETATION: Although surgeon experience differed across days of the week, the risk of 30-day mortality after elective surgery was similar regardless of which day of the week the procedure took place., In 3 prior studies, a higher risk of death was observed among patients who had elective surgery on a Friday than earlier in the week. (1-3) This 'weekday effect' was [...]

Published
2017
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