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3. Balloon catheters versus vaginal prostaglandins for labour induction (CPI Collaborative): an individual participant data meta-analysis of randomised controlled trials

Author

Jones, Madeleine N, Palmer, Kirsten R, Pathirana, Maleesa M, Cecatti, Jose Guilherme, Filho, Olimpio B Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E, Sass, Nelson, Jozwiak, Marta, Eikelder, Mieke Ten, Rengerink, Katrien Oude, Bloemenkamp, Kitty W M, Henry, Amanda, Løkkegaard, Ellen C L, Christensen, Ib Jarle, Szychowski, Jeff M, Edwards, Rodney K, Beckmann, Michael, Diguisto, Caroline, Gouge, Amélie Le, Perrotin, Franck, Symonds, Ian, O’Leary, Sean, Rolnik, Daniel L, Mol, Ben W, and Li, Wentao

Published
2022
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4. Tocolysis after preterm prelabor rupture of membranes and 5-year outcomes: a population-based cohort study

Author

Ancel, Pierre-Yves, Arnaud, Catherine, Arthuis, Chloé, Blanc, Julie, Boileau, Pascal, Debillon, Thierry, Delorme, Pierre, D’Ercole, Claude, Desplanches, Thomas, RM, PhD., Diguisto, Caroline, Foix-L’Hélias, Laurence, Gascoin, Géraldine, Gire, Catherine, Goffinet, François, Guellec, Isabelle, Kayem, Gilles, Langer, Bruno, Letouzey, Mathilde, Lorthe, Elsa, Maisonneuve, Emeline, Marret, Stéphane, Monier, Isabelle, Morgan, Andrei, Rozé, Jean-Christophe, Schmitz, Thomas, Sentilhes, Loïc, Subtil, Damien, Torchin, Héloïse, Tosello, Barthélémy, Vayssière, Christophe, Winer, Norbert, Zeitlin, Jennifer, Marchand-Martin, Laetitia, Aubert, Adrien M., Pierrat, Véronique, Benhammou, Valérie, and L’Hélias, Laurence Foix

Published
2024
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6. Management and outcomes of women with low fibrinogen concentration during pregnancy or immediately postpartum: A UK national population‐based cohort study.

Author

Diguisto, Caroline, Baker, Elfreda, Stanworth, Simon, Collins, Peter W., Collis, Rachel E., and Knight, Marian

Subjects
*AMNIOTIC fluid embolism, *ABRUPTIO placentae, *FIBRINOGEN, *BLOOD loss estimation, *PLACENTA accreta, *POSTPARTUM hemorrhage, *PUERPERIUM
Abstract

Introduction: Pregnant women with a fibrinogen level <2 g/L represent a high‐risk group that is associated with severe postpartum hemorrhage and other complications. Women who would qualify for fibrinogen therapy are not yet identified. Material and methods: A population‐based cross‐sectional study was conducted using the UK Obstetric Surveillance System between November 2017 and October 2018 in any UK hospital with a consultant‐led maternity unit. Any woman pregnant or immediately postpartum with a fibrinogen <2 g/L was included. Our aims were to determine the incidence of fibrinogen <2 g/L in pregnancy, and to describe its causes, management and outcomes. Results: Over the study period 124 women with fibrinogen <2 g/L were identified (1.7 per 10 000 maternities; 95% confidence interval 1.4–2.0 per 10 000 maternities). Less than 5% of cases of low fibrinogen were due to preexisting inherited dysfibrinogenemia or hypofibrinogenemia. Sixty percent of cases were due to postpartum hemorrhage caused by placental abruption, atony, or trauma. Amniotic fluid embolism and placental causes other than abruption (previa, accreta, retention) were associated with the highest estimated blood loss (median 4400 mL) and lowest levels of fibrinogen. Mortality was high with two maternal deaths due to massive postpartum hemorrhage, 27 stillbirths, and two neonatal deaths. Conclusions: Fibrinogen <2 g/L often, but not exclusively, affected women with postpartum hemorrhage due to placental abruption, atony, or trauma. Other more rare and catastrophic obstetrical events such as amniotic fluid embolism and placenta accreta also led to low levels of fibrinogen. Maternal and perinatal mortality was extremely high in our cohort. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study

Author

Arnaud, Catherine, Arthuis, Chloé, Blanc, Julie, Boileau, Pascal, Debillon, Thierry, D’Ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Garbi, Aurélie, Gascoin, Géraldine, Gire, Catherine, Langer, Bruno, Letouzey, Mathilde, Monier, RM, Isabelle, Morgan, Andrei, Rozé, Jean-Christophe, Schmitz, Thomas, Tosello, Barthélémy, Vayssiére, Christophe, Winer, Norbert, Zeitlin, Jennifer, Maisonneuve, Emeline, Lorthe, Elsa, Torchin, Héloïse, Delorme, Pierre, Devisme, Louise, L’Hélias, Laurence Foix, Marret, Stéphane, Subtil, Damien, Bodeau-Livinec, Florence, Pierrat, Véronique, Sentilhes, Loïc, Goffinet, François, Ancel, Pierre-Yves, and Kayem, Gilles

Published
2020
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10. Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: The EPIPAGE‐2 study

Author

Boileau, Pascal, primary, Letouzey, Mathilde, additional, Morgan, Andrei S., additional, Lorthe, Elsa, additional, Kaminski, Monique, additional, Coquelin, Anaëlle, additional, Azria, Elie, additional, Caeymaex, Laurence, additional, Rouget, Florence, additional, Diguisto, Caroline, additional, Claris, Olivier, additional, Tosello, Barthélémy, additional, Truffert, Patrick, additional, Bétrémieux, Pierre, additional, Benhammou, Valérie, additional, Marchand‐Martin, Laetitia, additional, Goffinet, François, additional, Ancel, Pierre‐Yves, additional, and Foix‐L'Hélias, Laurence, additional

Published
2023
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12. Balloon Catheters Versus Vaginal Prostaglandins for Labour Induction (CPI Collaborative): An Individual Participant Data Meta-analysis of Randomised Controlled Trials

Author

Jones, Madeleine N., primary, Palmer, Kirsten R., additional, Pathirana, Maleesa M., additional, Cecatti, Jose Guilherme, additional, Moraes Filho, Olimpio B., additional, Marions, Lena, additional, Edlund, Måns, additional, Prager, Martina, additional, Pennell, Craig, additional, Dickinson, Jan E., additional, Sass, Nelson, additional, Jozwiak, Marta, additional, Ten Eikelder, Mieke, additional, Rengerink, Katrien Oude, additional, Bloemenkamp, Kitty W. M., additional, Henry, Amanda, additional, Løkkegaard, Ellen C. L., additional, Christensen, Ib Jarle, additional, Szychowski, Jeff M., additional, Edwards, Rodney K., additional, Beckmann, Michael, additional, Diguisto, Caroline, additional, Le Gouge, Amélie, additional, Perrotin, Franck, additional, Symonds, Ian, additional, O'Leary, Sean, additional, Rolnik, Daniel L., additional, Mol, Ben W., additional, and Li, Wentao, additional

Published
2023
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14. Five‐year outcomes for extremely preterm babies with active perinatal management: A clinical prediction model.

Author

Diguisto, Caroline, Morgan, Andrei Scott, Foix L'Hélias, Laurence, Pierrat, Veronique, Ancel, Pierre‐Yves, Cohen, Jérémie F., and Goffinet, Francois

Subjects
*PREMATURE infants, *PREDICTION models, *ASPHYXIA neonatorum, *GESTATIONAL age, *NEWBORN infants, *SURVIVAL rate
Abstract

Objective: To develop and validate a clinical prediction model for outcomes at 5 years of age for children born extremely preterm and receiving active perinatal management. Design: The EPIPAGE‐2 national prospective cohort. Setting: France, 2011. Population: Live‐born neonates between 24+0 and 26+6 weeks of gestation who received active perinatal management (i.e. birth in a tertiary‐level hospital, with antenatal steroids and resuscitation at birth). Methods: A prediction model using logistic modelling, including gestational age, small‐for gestational‐age (SGA) status and sex, was developed. Model performance was assessed through calibration and discrimination, with bootstrap internal validation. Main outcome measures: Survival without moderate or severe neurodevelopmental disability (NDD) at 5 years. Results: Among the 557 neonates included, 401 (72%) survived to 5 years, of which 59% survived without NDD (95% CI 54% to 63%). Predicted rates of survival without NDD ranged from 45% (95% CI 33% to 57%), to 56% (95% CI 49% to 64%) to 64% (95% CI 57% to 70%) for neonates born at 24, 25 and 26 weeks of gestation, respectively. Predicted rates of survival without NDD were 47% (95% CI 18% to 76%) and 62% (95% CI 49% to 76%) for SGA and non‐SGA children, respectively. The model showed good calibration (calibration slope 0.85, 95% CI 0.54 to 1.16; calibration‐in‐the‐large −0.0123, 95% CI −0.25 to 0.23) and modest discrimination (C‐index 0.59, 95% CI 0.53 to 0.65). Conclusions: A simple prediction model using three factors easily known antenatally may help doctors and families in their decision‐making for extremely preterm neonates receiving active perinatal management. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Oxytocin versus prostaglandins for labour Induction of women with an unfavourable cervix after 24 hours of cervical ripening (OPIC): protocol for an open multicentre randomised non-inferiority trial

Author

De Berti, Marion, primary, Le Gouge, Amélie, additional, Monmousseau, Fanny, additional, Gallot, Denis, additional, Sentilhes, Loïc, additional, Winer, Norbert, additional, Legendre, Guillaume, additional, Desbriere, Raoul, additional, Girault, Aude, additional, Pozzi, Jordan, additional, Gachon, Bertrand, additional, Barjat, Thiphaine, additional, Perrotin, Franck, additional, Brunet-Houdard, Solène, additional, and Diguisto, Caroline, additional

Published
2023
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16. Balloon Catheters Versus Vaginal Prostaglandins for Labour Induction (CPI Collaborative):An Individual Participant Data Meta-analysis of Randomised Controlled Trials

Author

Jones, Madeleine N., Palmer, Kirsten R., Pathirana, Maleesa M., Cecatti, Jose Guilherme, Filho, Olimpio B. Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E., Sass, Nelson, Jozwiak, Marta, Ten Eikelder, Mieke, Rengerink, Katrien Oude, Bloemenkamp, Kitty W. M., Henry, Amanda, Løkkegaard, Ellen C. L., Christensen, Ib Jarle, Szychowski, Jeff M., Edwards, Rodney K., Beckmann, Michael, Diguisto, Caroline, Le Gouge, Amélie, Perrotin, Franck, Symonds, Ian, O'Leary, Sean, Rolnik, Daniel L., Mol, Ben W., Li, Wentao, Jones, Madeleine N., Palmer, Kirsten R., Pathirana, Maleesa M., Cecatti, Jose Guilherme, Filho, Olimpio B. Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E., Sass, Nelson, Jozwiak, Marta, Ten Eikelder, Mieke, Rengerink, Katrien Oude, Bloemenkamp, Kitty W. M., Henry, Amanda, Løkkegaard, Ellen C. L., Christensen, Ib Jarle, Szychowski, Jeff M., Edwards, Rodney K., Beckmann, Michael, Diguisto, Caroline, Le Gouge, Amélie, Perrotin, Franck, Symonds, Ian, O'Leary, Sean, Rolnik, Daniel L., Mol, Ben W., and Li, Wentao

Published
2023

17. Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system: The MAGPOP randomised controlled trial

Author

Diguisto, Caroline, Le Gouge, Amélie, Arthuis, Chloé, Winer, Norbert, Parant, Olivier, Poncelet, Christophe, Chauleur, Celine, Hannigsberg, Jacob, Ducarme, Guillaume, Gallot, Denis, Gabriel, Rene, Desbriere, Raoul, Beucher, Gael, Faraguet, Cyrille, Isly, Helene, Rozenberg, Patrick, Giraudeau, Bruno, and Perrotin, Franck

Subjects
Balloon dilatation -- Usage -- Comparative analysis, Pregnancy, Protracted -- Care and treatment, Dinoprostone -- Dosage and administration -- Comparative analysis, Labor, Induced (Obstetrics) -- Methods, Biological sciences
Abstract

Background Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method is currently recommended for cervical ripening of prolonged pregnancies. This trial evaluates whether the use of mechanical cervical ripening with a silicone double balloon catheter for induction of labour in prolonged pregnancies reduces the cesarean section rate for nonreassuring fetal status compared with pharmacological cervical ripening by a vaginal pessary for the slow release of dinoprostone (prostaglandin E2). Methods and findings This is a multicentre, superiority, open-label, parallel-group, randomised controlled trial conducted in 15 French maternity units. Women with singleton pregnancies, a vertex presentation, [greater than or equal to]41+0 and [less than or equal to]42+0 weeks' gestation, a Bishop score Conclusions In this study, we observed no difference in the rates of cesarean deliveries for nonreassuring fetal status between mechanical ripening with a silicone double balloon catheter and pharmacological cervical ripening with a pessary for the slow release of dinoprostone. Trial registration ClinicalTrials.gov NCT02907060., Author(s): Caroline Diguisto 1,2,3,*, Amélie Le Gouge 4, Chloé Arthuis 5, Norbert Winer 5, Olivier Parant 6, Christophe Poncelet 7,8, Celine Chauleur 9,10, Jacob Hannigsberg 11, Guillaume Ducarme 12, Denis [...]

Published
2021
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18. Chorionicity and neurodevelopmental outcomes at 5½ years among twins born preterm: the EPIPAGE2 cohort study.

Author

Hoarau, Delphine, Tosello, Barthélémy, Blanc, Julie, Lorthe, Elsa, Foix‐L'Helias, Laurence, D'Ercole, Claude, Winer, Norbert, Subtil, Damien, Goffinet, François, Kayem, Gilles, Resseguier, Noémie, Gire, Catherine, Ancel, Pierre‐Yves, Arnaud, Catherine, Arthuis, Chloé, Boileau, Pascal, Debillon, Thierry, Delorme, Pierre, Desplanches, Thomas, and Diguisto, Caroline

Subjects
FETOFETAL transfusion, NEURAL development, APRAXIA, TWINS, COHORT analysis, CEREBRAL palsy
Abstract

Objective: To compare the neurodevelopmental outcomes of preterm twins at 5½ years by chorionicity of pregnancy. Design: Prospective nationwide population‐based EPIPAGE2 (Etude Epidémiologique sur les Petits Âges Gestationnels) cohort study. Setting: A total of 546 maternity units in France, between March and December 2011. Population: A total of 1126 twins eligible for follow‐up at 5½ years. Methods: The association of chorionicity with outcomes was analysed using multivariate regression models. Main outcome measures: Survival at 5½ years with or without neurodevelopmental disabilities (comprising cerebral palsy, visual, hearing, cognitive deficiency, behavioural difficulties or developmental coordination disorders) were described and compared by chorionicity. Results: Among the 1126 twins eligible for follow‐up at 5½ years, 926 (82.2%) could be evaluated: 228 monochorionic (MC) and 698 dichorionic (DC). Based on chronicity and gestational age of birth, we found no significant differences for severe neonatal morbidity. The rates of moderate/severe neurobehavioral disabilities were similar in infants from DC pregnancies versus infants from MC pregnancies (OR 1.22, 95% CI 0.65–2.28). By gestational age and without twin–twin transfusion syndrome (TTTS), no difference according to chorionicity was found for all neurodevelopmental outcome measures. Conclusions: The neurodevelopmental outcomes among preterm twins at 5½ years is similar, irrespective of chorionicity. Linked article: This article is commented on by R. N. Brown, pp. 1059 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17527. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Survival and neurodevelopmental impairment of outborn preterm infants at 5.5 years of age: an EPIPAGE-2 prospective, matched study using multiple imputation

Author

Jones, Peter, primary, Marchand-Martin, Laetitia, additional, Desplanches, Thomas, additional, Diguisto, Caroline, additional, Fresson, Jeanne, additional, Goffinet, François, additional, Dauger, Stéphane, additional, Ancel, Pierre-Yves, additional, and Morgan, Andrei Scott, additional

Published
2022
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21. Maternal mortality in eight European countries with enhanced surveillance systems: descriptive population based study

Author

Diguisto, Caroline, primary, Saucedo, Monica, additional, Kallianidis, Athanasios, additional, Bloemenkamp, Kitty, additional, Bødker, Birgit, additional, Buoncristiano, Marta, additional, Donati, Serena, additional, Gissler, Mika, additional, Johansen, Marianne, additional, Knight, Marian, additional, Korbel, Miroslav, additional, Kristufkova, Alexandra, additional, Nyflot, Lill T, additional, and Deneux-Tharaux, Catherine, additional

Published
2022
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22. Low-dose aspirin to prevent preeclampsia and growth restriction in nulliparous women identified by uterine artery Doppler as at high risk of preeclampsia: A double blinded randomized placebo-controlled trial

Author

Diguisto, Caroline, Le Gouge, Amelie, Marchand, Marie-Sara, Megier, Pascal, Ville, Yves, Haddad, Georges, Winer, Norbert, Arthuis, Chloé, Doret, Muriel, Debarge, Veronique Houfflin, Flandrin, Anaig, Delmas, Hélène Laurichesse, Gallot, Denis, Mares, Pierre, Vayssiere, Christophe, Sentilhes, Loïc, Cheve, Marie-Therese, Paumier, Anne, Durin, Luc, Schaub, Bruno, Equy, Veronique, Giraudeau, Bruno, Perrotin, Franck, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Maternité Olympe de Gouges [CHRU Tours], Centre d’Investigation Clinique [Tours] CIC 1415 (CIC ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional d'Orléans (CHRO), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), CHU Lille, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Clermont-Ferrand, Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aix-Marseille Université - École de maïeutique (AMU SMPM EM), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Centre Hospitalier Le Mans (CH Le Mans), Polyclinique de l’Atlantique, Partenaires INRAE, Elsan Polyclinique du Parc - Caen, CHU de la Martinique [Fort de France], CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, and Université de Tours (UT)

Subjects
Male, Uterine Artery, Pregnancy Trimester, First, Multidisciplinary, Pre-Eclampsia, Aspirin, Pregnancy, [SDV]Life Sciences [q-bio], Infant, Newborn, Humans, Birth Weight, Female
Abstract

Introduction This trial evaluates whether daily low-dose aspirin initiated before 16 weeks of gestation can reduce preeclampsia and fetal growth restriction in nulliparous women identified by first-trimester uterine artery Dopplers as at high risk of preeclampsia. Methods This randomized, blinded, placebo-controlled, parallel-group trial took place in 17 French obstetric departments providing antenatal care. Pregnant nulliparous women aged ≥ 18 years with a singleton pregnancy at a gestational age < 16 weeks of gestation with a lowest pulsatility index ≥ 1.7 or a bilateral protodiastolic notching for both uterine arteries on an ultrasound performed between 11+0 and 13+6 weeks by a certified sonographer were randomized at a 1:1 ratio to 160 mg of low-dose aspirin or to placebo to be taken daily from inclusion to their 34th week of gestation. The main outcome was preeclampsia or a birthweight ≤ 5th percentile. Other outcomes included preeclampsia, severe preeclampsia, preterm preeclampsia, preterm delivery before 34 weeks, mode of delivery, type of anesthesia, birthweight ≤ 5th percentile and perinatal death. Results The trial was interrupted due to recruiting difficulties. Between June 2012 and June 2016, 1104 women were randomized, two withdrew consent, and two had terminations of pregnancies. Preeclampsia or a birthweight ≤ 5th percentile occurred in 88 (16.0%) women in the low-dose aspirin group and in 79 (14.4%) in the placebo group (proportion difference 1.6 [-2.6; 5.9] p = 0.45). The two groups did not differ significantly for the secondary outcomes. Conclusion Low-dose aspirin was not associated with a lower rate of either preeclampsia or birthweight ≤ 5th percentile in women identified by their first-trimester uterine artery Doppler as at high risk of preeclampsia. Trial registration (NCT0172946).

Published
2022

24. Balloon catheters versus vaginal prostaglandins for labour induction (CPI Collaborative):an individual participant data meta-analysis of randomised controlled trials

Author

Jones, Madeleine N., Palmer, Kirsten R., Pathirana, Maleesa M., Cecatti, Jose Guilherme, Filho, Olimpio B.Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E., Sass, Nelson, Jozwiak, Marta, Eikelder, Mieke Ten, Rengerink, Katrien Oude, Bloemenkamp, Kitty W.M., Henry, Amanda, Løkkegaard, Ellen C.L., Christensen, Ib Jarle, Szychowski, Jeff M., Edwards, Rodney K., Beckmann, Michael, Diguisto, Caroline, Gouge, Amélie Le, Perrotin, Franck, Symonds, Ian, O'Leary, Sean, Rolnik, Daniel L., Mol, Ben W., Li, Wentao, Jones, Madeleine N., Palmer, Kirsten R., Pathirana, Maleesa M., Cecatti, Jose Guilherme, Filho, Olimpio B.Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E., Sass, Nelson, Jozwiak, Marta, Eikelder, Mieke Ten, Rengerink, Katrien Oude, Bloemenkamp, Kitty W.M., Henry, Amanda, Løkkegaard, Ellen C.L., Christensen, Ib Jarle, Szychowski, Jeff M., Edwards, Rodney K., Beckmann, Michael, Diguisto, Caroline, Gouge, Amélie Le, Perrotin, Franck, Symonds, Ian, O'Leary, Sean, Rolnik, Daniel L., Mol, Ben W., and Li, Wentao

Abstract

Background: Induction of labour is one of the most common obstetric interventions globally. Balloon catheters and vaginal prostaglandins are widely used to ripen the cervix in labour induction. We aimed to compare the effectiveness and safety profiles of these two induction methods. Methods: We did an individual participant data meta-analysis comparing balloon catheters and vaginal prostaglandins for cervical ripening before labour induction. We systematically identified published and unpublished randomised controlled trials that completed data collection between March 19, 2019, and May 1, 2021, by searching the Cochrane Library, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, and PubMed. Further trials done before March 19, 2019, were identified through a recent Cochrane review. Data relating to the combined use of the two methods were not included, only data from women with a viable, singleton pregnancy were analysed, and no exclusion was made based on parity or membrane status. We contacted authors of individuals trials and participant-level data were harmonised and recoded according to predefined definitions of variables. Risk of bias was assessed with the ROB2 tool. The primary outcomes were caesarean delivery, indication for caesarean delivery, a composite adverse perinatal outcome, and a composite adverse maternal outcome. We followed the intention-to-treat principle for the main analysis. The primary meta-analysis used two-stage random-effects models and the sensitivity analysis used one-stage mixed models. All models were adjusted for maternal age and parity. This meta-analysis is registered with PROSPERO (CRD42020179924). Findings: Individual participant data were available from 12 studies with a total of 5460 participants. Balloon catheters, compared with vaginal prostaglandins, did not lead to a significantly different rate of caesarean delivery (12 trials, 5414 women; crude incidence 27·0%; adjusted OR [aOR] 1·09, 95% CI 0·95

Published
2022

25. Balloon catheters versus vaginal prostaglandins for labour induction (CPI Collaborative): an individual participant data meta-analysis of randomised controlled trials

Author

Datamanagement 1, Research UMC Utrecht, CTM & Statistical consultation, MS Verloskunde, Child Health, Jones, Madeleine N., Palmer, Kirsten R., Pathirana, Maleesa M., Cecatti, Jose Guilherme, Filho, Olimpio B.Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E., Sass, Nelson, Jozwiak, Marta, Eikelder, Mieke Ten, Rengerink, Katrien Oude, Bloemenkamp, Kitty W.M., Henry, Amanda, Løkkegaard, Ellen C.L., Christensen, Ib Jarle, Szychowski, Jeff M., Edwards, Rodney K., Beckmann, Michael, Diguisto, Caroline, Gouge, Amélie Le, Perrotin, Franck, Symonds, Ian, O'Leary, Sean, Rolnik, Daniel L., Mol, Ben W., Li, Wentao, Datamanagement 1, Research UMC Utrecht, CTM & Statistical consultation, MS Verloskunde, Child Health, Jones, Madeleine N., Palmer, Kirsten R., Pathirana, Maleesa M., Cecatti, Jose Guilherme, Filho, Olimpio B.Moraes, Marions, Lena, Edlund, Måns, Prager, Martina, Pennell, Craig, Dickinson, Jan E., Sass, Nelson, Jozwiak, Marta, Eikelder, Mieke Ten, Rengerink, Katrien Oude, Bloemenkamp, Kitty W.M., Henry, Amanda, Løkkegaard, Ellen C.L., Christensen, Ib Jarle, Szychowski, Jeff M., Edwards, Rodney K., Beckmann, Michael, Diguisto, Caroline, Gouge, Amélie Le, Perrotin, Franck, Symonds, Ian, O'Leary, Sean, Rolnik, Daniel L., Mol, Ben W., and Li, Wentao

Published
2022

26. Maternal mortality in eight European countries with enhanced surveillance systems: Descriptive population based study

Author

MS Verloskunde, Child Health, Geboortecentrum voorzitterschap, Diguisto, Caroline, Saucedo, Monica, Kallianidis, Athanasios, Bloemenkamp, Kitty, Bødker, Birgit, Buoncristiano, Marta, Donati, Serena, Gissler, Mika, Johansen, Marianne, Knight, Marian, Korbel, Miroslav, Kristufkova, Alexandra, Nyflot, Lill T., Deneux-Tharaux, Catherine, MS Verloskunde, Child Health, Geboortecentrum voorzitterschap, Diguisto, Caroline, Saucedo, Monica, Kallianidis, Athanasios, Bloemenkamp, Kitty, Bødker, Birgit, Buoncristiano, Marta, Donati, Serena, Gissler, Mika, Johansen, Marianne, Knight, Marian, Korbel, Miroslav, Kristufkova, Alexandra, Nyflot, Lill T., and Deneux-Tharaux, Catherine

Published
2022

27. Delivery room deaths of extremely preterm babies: an observational study

Author

Durrmeyer, Xavier, Scholer-Lascourrèges, Claire, Boujenah, Laurence, Bétrémieux, Pierre, Claris, Olivier, Garel, Micheline, Kaminski, Monique, Foix-LʼHelias, Laurence, Caeymaex, Laurence, Azria, Elie, Beuchée, Alain, Boileau, Pascal, Charlot, Frédérique, Coquelin, Anaëlle, Diguisto, Caroline, Foix LʼHélias, Laurence, Kuhn, Pierre, Levaillant, Cerise, Rouget, Florence, Simeoni, Umberto, Tosello, Barthélemy, and Truffert, Patrick

Published
2017
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28. Antibiotic prophylaxis in preterm premature rupture of membranes at 24–31 weeks’ gestation: Perinatal and 2‐year outcomes in the EPIPAGE‐2 cohort

Author

Lorthe, Elsa, Letouzey, Mathilde, Torchin, Héloïse, Foix L'Helias, Laurence, Gras‐le Guen, Christèle, Benhammou, Valérie, Boileau, Pascal, Charlier, Caroline, Kayem, Gilles, Ancel, Pierre‐yves, Arnaud, Catherine, Blanc, Julie, Debillon, Thierry, Delorme, Pierre, D’ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Gascoin, Géraldine, Gire, Catherine, Goffinet, François, Langer, Bruno, Maisonneuve, Emeline, Marret, Stéphane, Monier, Isabelle, Morgan, Andrei, Rozé, Jean‐christophe, Schmitz, Thomas, Sentilhes, Loïc, Subtil, Damien, Tosello, Barthélémy, Vayssière, Christophe, Winer, Norbert, Zeitlin, Jennifer, Astruc, D, Kuhn, P, Matis, J, Ramousset, C, Hernandorena, X, Chabanier, P, Joly‐pedespan, L, Costedoat, Mj, Leguen, A, Lecomte, B, Lemery, D, Vendittelli, F, Beucher, G, Dreyfus, M, Guillois, B, Toure, Y, Burguet, A, Couvreur, S, Gouyon, Jb, Sagot, P, Colas, N, Sizun, J, Beuchée, A, Pladys, P, Rouget, F, Dupuy, Rp, Soupre, D, Charlot, F, Roudaut, S, Favreau, A, Saliba, E, Reboul, L, Bednarek, N, Morville, P, Verrière, V, Thiriez, G, Balamou, C, Marpeau, L, Barbier, C, Durrmeyer, X, Granier, M, Ayoubi, M, Baud, O, Carbonne, B, Jarreau, Ph, Mitanchez, D, Duffaut, C, Cornu, L, Moras, R, Boulot, P, Cambonie, G, Daudé, H, Badessi, A, Tsaoussis, N, Bédu, A, Mons, F, Bahans, C, Binet, Mh, Fresson, J, Hascoët, Jm, Milton, A, Morel, O, Vieux, R, Hilpert, L, Alberge, C, Baron, M, Charkaluk, Ml, Pierrat, V, Truffert, P, Akowanou, S, Simeoni, U, Bongain, A, Deschamps, M, Branger, B, Rouger, V, Dupont, C, Gondry, Jean, Krim, G, Baby, B, Debeir, M, Claris, O, Picaud, Jc, Rubio‐gurung, S, Cans, C, Ego, A, Patural, H, Rannaud, A, Janky, E, Poulichet, A, Rosenthal, Jm, Coliné, E, Favre, A, Joly, N, Châlons, S, Pignol, J, Laurence, Pl, Robillard, Py, Samperiz, S, Ramful, D, Blondel, B, Bonet, M, Brinis, A, Coquelin, A, Durox, M, Kaminski, M, Khemache, K, Khoshnood, B, Lebeaux, C, Marchand‐martin, L, Rousseau, J, Saurel‐cubizolles, Mj, Tran, D, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier universitaire de Nantes (CHU Nantes), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris], Assistance Publique - Hôpitaux de Paris, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service Epidémiologie clinique et santé publique [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Unité de biostatistiques [Centre Georges-François Leclerc], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Médecine Néonatale et Réanimation Pédiatrique CHU Grenoble, CHU Grenoble, Service de gynécologie-obstétrique [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Service de Néonatologie, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Recherches épidémiologiques en santé périnatale et santé des femmes, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 (GRAMFC), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Funding information:This work was partly supported by a postdoctoral grant from the Fondation des Treilles to EL. EPIPAGE-2 was funded by the French Institute of Public Health Research (IRESP TGIR 2009-01 programme)/Institute of Public Health and its partners: the French Health Ministry, the National Institute of Health and Medical Research (INSERM), the National Institute of Cancer, and the National Solidarity Fund for Autonomy (CNSA), the National Research Agency through the French EQUIPEX programme of investments for the future (grant number ANR-11-EQPX-0038), and the PREMUP Foundation. Additional funding was obtained from Fondation pour la Recherche Medicale (grant number SPF 20160936356) and Fondation de France (grant numbers 00050329, Grand Prix R18202KK]). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript., ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Education, Formation, Travail, Savoirs (EFTS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Centre Hospitalier Universitaire [Grenoble] (CHU), Modélisation et Évaluation des données complexes en Santé Publique (TIMC-MESP), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Dijon, Hôpital Nord [CHU - APHM], Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Department of Obstetrics and Gynecology, Les Hôpitaux Universitaires de Strasbourg (HUS), EPIPAGE-2 Study Group, and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Fetal Membranes, Premature Rupture, obstetric intervention, [SDV]Life Sciences [q-bio], Gestational Age, antenatal management, Cohort Studies, Pregnancy, Escherichia coli, Humans, Prospective Studies, latency, amoxicillin, neurodevelopment, macrolides, prematurity, Infant, Newborn, Pregnancy Outcome, Obstetrics and Gynecology, Infant, prophylactic antibiotics, Antibiotic Prophylaxis, Anti-Bacterial Agents, perinatal outcome, cephalosporins, Premature Birth, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neonatal Sepsis, Infant, Premature
Abstract

To compare different antibiotic prophylaxis administered after preterm premature rupture of membranes to determine whether any were associated with differences in obstetric and/or neonatal outcomes and/or neurodevelopmental outcomes at 2 years of corrected age.Prospective, nationwide, population-based EPIPAGE-2 cohort study of preterm infants.France, 2011.We included 492 women with a singleton pregnancy and a diagnosis of preterm premature rupture of membranes at 24-31 weeks. Exclusion criteria were contraindication to expectant management or indication for antibiotic therapy other than preterm premature rupture of membranes. Antibiotic prophylaxis was categorised as amoxicillin (n = 345), macrolide (n = 30), third-generation cephalosporin (n = 45) or any combinations covering Streptococcus agalactiae and90% of Escherichia coli (n = 72), initiated within 24 hours after preterm premature rupture of membranes.Population-averaged robust Poisson models.Survival at discharge without severe neonatal morbidity, 2-year neurodevelopment.With amoxicillin, macrolide, third-generation cephalosporin and combinations, 78.5%, 83.9%, 93.6% and 86.0% of neonates were discharged alive without severe morbidity. The administration of third-generation cephalosporin or any E. coli-targeting combinations was associated with improved survival without severe morbidity (adjusted risk ratio 1.25 [95% confidence interval 1.08-1.45] and 1.10 [95 % confidence interval 1.01-1.20], respectively) compared with amoxicillin. We evidenced no increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.In preterm premature rupture of membranes at 24-31 weeks, antibiotic prophylaxis based on third-generation cephalosporin may be associated with improved survival without severe neonatal morbidity when compared with amoxicillin, with no evidence of increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.Antibiotic prophylaxis after PPROM at 24-31 weeks: 3rd-generation cephalosporins associated with improved neonatal outcomes.

Published
2022

29. A comparison of balloon catheters and vaginal prostaglandins for cervical ripening prior to labour induction

Author

Jones, Madeleine, primary, Palmer, Kirsten, additional, Pathirana, Maleesa M., additional, Cecatti, Jose Guilherme, additional, Moraes Filho, Olimpio B., additional, Marions, Lena, additional, Prager, Martina, additional, Edlund, Måns, additional, Jozwiak, Marta, additional, Eikelder, Mieke Ten, additional, Rengerink, Katrien Oude, additional, Bloemenkamp, Kitty W.M., additional, Henry, Amanda, additional, Beckmann, Mike, additional, Kumar, Sailesh, additional, Diguisto, Caroline, additional, Le Gouge, Amélie, additional, Perrotin, Franck, additional, Symonds, Ian, additional, O'Leary, Sean, additional, Rolnik, Daniel L., additional, Mol, Ben W., additional, and Li, Wentao, additional

Published
2022
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31. Term prelabor rupture of membranes: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF).

Author

Sénat, Marie-Victoire, Schmitz, Thomas, Bouchghoul, Hanane, Diguisto, Caroline, Girault, Aude, Paysant, Sabine, Sibiude, Jeanne, Lassel, Linda, and Sentilhes, Loïc

Abstract

To determine the management of patients with term prelabor rupture of membranes. Synthesis of the literature from the PubMed and Cochrane databases and the recommendations of French and foreign societies and colleges. Term prelabor rupture of membranes is considered a physiological process until 12 h have passed since rupture (professional consensus). In cases of expectant management and with a low rate of antibiotic prophylaxis, home care may be associated with an increase in neonatal infections (LE3), compared with hospitalization, especially for women with group B streptococcus (GBS) colonization (LE3). Home care is therefore not recommended (grade C). In the absence of spontaneous labor within 12 h of rupture, antibiotic prophylaxis may reduce the risk of maternal intrauterine infection but not of neonatal infection (LE3). Its use after 12 h of rupture in term prelabor rupture of the membranes is therefore recommended (grade C). When antibiotic prophylaxis is indicated, intravenous beta-lactams are recommended (grade C). Induction of labor with oxytocin (LE1), prostaglandin E2 (LE1), or misoprostol (LE1) is associated with shorter rupture-to-delivery intervals than expectant management; immediate induction is not, however, associated with lower rates of neonatal infection (LE1), even among women with a positive GBS vaginal swab (LE2). Thus, expectant management can be offered without increasing the risk of neonatal infection (grade B). Induction of labor is not associated with either an increase or decrease in the cesarean rate (LE2), regardless of parity (LE2) or Bishop score at admission (LE3). Induction can thus be proposed without increasing the risk of cesarean delivery (grade B). No induction method (oxytocin, dinoprostone, misoprostol, or Foley catheter) has demonstrated superiority over any another method for reducing rates of intrauterine or neonatal infection or of cesarean delivery or for shortening the rupture-to-delivery intervals, regardless of parity or the Bishop score. Term prelabor rupture of membranes is a frequent event. A 12-hour interval without onset of spontaneous labor was chosen to differentiate a physiological condition from a potentially unsafe situation that justifies antibiotic prophylaxis. Expectant management or induction of labor can each be proposed, even in case of positive screening for group streptococcus. The decision should depend on the woman's wishes and maternity unit organization (professional consensus). [ABSTRACT FROM AUTHOR]

Published
2022
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32. Risk factors for very preterm delivery out of a level III maternity unit: The EPIPAGE‐2 cohort study

Author

Desplanches, Thomas, primary, Morgan, Andrei S., additional, Jones, Peter, additional, Diguisto, Caroline, additional, Zeitlin, Jennifer, additional, Martin‐Marchand, Laetitia, additional, Benhammou, Valérie, additional, Lecomte, Bénédicte, additional, Rozé, Jean‐Christophe, additional, Truffert, Patrick, additional, Ancel, Pierre‐Yves, additional, Sagot, Paul, additional, Roussot, Adrien, additional, Fresson, Jeanne, additional, and Blondel, Béatrice, additional

Published
2021
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34. Rapport d’Experts et Recommandations CNGOF-SFT sur la prise en charge du tabagisme en cours de grossesse – texte court

Author

Grangé, Gilles, Berlin, Ivan, Bretelle, Florence, Bertholdt, Charline, Berveiller, Paul, Blanc, Julie, Diguisto, Caroline, Dochez, Vincent, Garabedian, Charles, Guerby, Paul, Koch, Antoine, Lous, Maela Le, Perdriolle-Galet, Estelle, Peyronnet, Violaine, Emmanuel, Rault, Torchin, Héloise, Legendre, Guillaume, Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance Publique - Hôpitaux de Marseille (APHM), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Maternité Régionale Adolphe Pinard [Nancy], Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de gynécologie et obstétrique [CHI Poissy-Saint Germain], CHI Poissy-Saint-Germain, Service de gynécologie-obstétrique [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre hospitalier universitaire de Nantes (CHU Nantes), Environnement périnatal et croissance - EA 4489 (EPS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Strasbourg, CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Louis Mourier - AP-HP [Colombes], Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de pharmacologie médicale [CHU Pitié-Salpêtrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Environnement périnatal et croissance, Université de Lille, Droit et Santé, CHU Toulouse [Toulouse], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Nord [CHU - APHM]-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU), and Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)

Subjects
Essais cliniques, Nicotine, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Études observationnelles, Tabagisme, Sevrage tabagique, Déterminants, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Tabagisme passif, Épidémiologie, traitement substitutif nicotinique, Grossesse, Facteurs de risque, Allaitement maternel, Revue de la littérature, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Revue systématique, Prédicteurs, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Méta-analyse, Comportements, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Interventions, Post-partum
Abstract

International audience; Objectives - To provide up-to-date evidence-based guidelines for the management of smoking cessation during pregnancy. Methods - Systematic review of the international literature. We identified papers published between January 2003 and April 2019 in Cochrane PubMed, and Embase databases with predefined keywords. All reports published in French and English relevant to the areas of focus were included and classified according the level of evidence ranging from 1 (highest) to 4 (lowest). The strength of the recommendations was classified according to the Haute Autorité de santé, France (ranging from A, highest to C, lowest). Results - "Counseling", involving globally all kind of non-pharmacological interventions, has a modest benefit on smoking cessation, birth weight and prematurity. Moderate physical activity did not show a significant effect on smoking cessation. The systematic use of feedback by measuring the expired air carbon monoxide concentration do not influence smoking abstinence but it may be used in establishing a therapeutic alliance. The use of self-help interventions and health education are recommended in helping pregnant smokers quit. The prescription of nicotine replacement therapies (NRT) may be offered to any pregnant woman who has failed stopping smoking without medication This prescription can be initiated by the health care professional taking care of the pregnant woman in early pregnancy. There is no scientific evidence to propose the electronic cigarette for smoking cessation to pregnant smokers; it is recommended to provide the same advice and to use methods that have already been evaluated. The use of waterpipe (shisha/narghile) during pregnancy is associated with decreased fetal growth. It is recommended not to use waterpipe during pregnancy. Breastfeeding is possible in smokers, but less often initiated by them. Although its benefit for the child's development is not demonstrated to date, breastfeeding allows the mother to reduce or stop smoking. The risk of postpartum relapse is high (up to 82% at 1 year). The main factors associated with postpartum abstinence are breastfeeding, not having a smoker at home, and having no symptoms of postpartum depression. Conclusions - Smoking during pregnancy concerns more than hundred thousand women and their children per year in France. It is a major public health burden. Health care professionals should be mobilized for reducing or even eradicating it.

Published
2020

35. MOESM2 of Intensity of perinatal care for extremely preterm babies and outcomes at a higher gestational age: evidence from the EPIPAGE-2 cohort study

Author

Morgan, Andrei, Khoshnood, Babak, Diguisto, Caroline, L’Helias, Laurence Foix, Marchand-Martin, Laetitia, Kaminski, Monique, Zeitlin, Jennifer, Bréart, Gérard, Goffinet, François, and Pierre-Yves Ancel

Subjects
digestive system diseases
Abstract

Additional file 2 S2 appendix: Supplementary results relating to intensity of perinatal care for extremely preterm babies and outcomes at a higher gestational age.

Published
2020
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37. A study of diabetic ketoacidosis in the pregnant population in the United Kingdom: Investigating the incidence, aetiology, management and outcomes.

Author

Diguisto, Caroline, Strachan, Mark W. J., Churchill, David, Ayman, Goher, and Knight, Marian

Subjects
*CONFIDENCE intervals, *DISEASE incidence, *CASE-control method, *MEDICATION errors, *RISK assessment, *VOMITING, *DIABETIC acidosis, *DISEASE risk factors, *SYMPTOMS, *PREGNANCY
Abstract

Aim: To estimate the incidence of diabetic ketoacidosis (DKA) among pregnant women, describe its clinical features, management and outcomes and identify the risk factors for the condition. Methods: A national population‐based case–control study was conducted in the UK using the UK Obstetric Surveillance System between April 2019 and September 2020 including all pregnant women with DKA irrespective of the level of blood glucose. The incidence rate of DKA in pregnancy was estimated. A case–control analysis limited to women with type 1 diabetes was performed comparing characteristics of women with DKA (cases) to those of women whose pregnancies were not complicated by DKA (controls). Results: In all, 82 women were identified with DKA in pregnancy; 6.3 per 100,000 maternities (95% CI: 5.0–7.9). No maternal deaths occurred, but perinatal mortality was 12/73 (16%) with 11 stillbirths and one neonatal death. DKA episodes mostly occurred in women with type 1 diabetes (85%) and in the 3rd trimester of pregnancy (71%). Episodes were mainly precipitated by infection (21%), vomiting (21%), steroid therapy (13%) and medication errors (10%). Fifteen percent of women had more than one episode of DKA during their pregnancy. Risk factors associated with DKA among women with type 1 diabetes identified through the case–control analysis were the woman and/or partner not being in a paid employment and having at least one microvascular complication of diabetes before pregnancy. Conclusion: DKA in pregnancy was associated with high perinatal mortality and was linked with factors related to socio‐economic deprivation, mental health problems and long‐term difficulties with glycaemic control. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Association between extremely preterm caesarean delivery and maternal depressive and anxious symptoms: a national population‐based cohort study

Author

Blanc, J, primary, Rességuier, N, additional, Lorthe, E, additional, Goffinet, F, additional, Sentilhes, L, additional, Auquier, P, additional, Tosello, B, additional, d'Ercole, C, additional, Ancel, Pierre‐Yves, additional, Arnaud, Catherine, additional, Blanc, Julie, additional, Boileau, Pascal, additional, Debillon, Thierry, additional, Delorme, Pierre, additional, D’Ercole, Claude, additional, Desplanches, Thomas, additional, Diguisto, Caroline, additional, Foix‐L’Hélias, Laurence, additional, Garbi, Aurélie, additional, Gascoin, Géraldine, additional, Gaudineau, Adrien, additional, Gire, Catherine, additional, Goffinet, François, additional, Kayem, Gilles, additional, Langer, Bruno, additional, Letouzey, Mathilde, additional, Lorthe, Elsa, additional, Maisonneuve, Emeline, additional, Marret, Stéphane, additional, Monier, Isabelle, additional, Morgan, Andrei, additional, Rozé, Jean‐Christophe, additional, Schmitz, Thomas, additional, Sentilhes, Loïc, additional, Subtil, Damien, additional, Torchin, Héloïse, additional, Tosello, Barthélémy, additional, Vayssière, Christophe, additional, Winer, Norbert, additional, and Zeitlin, Jennifer, additional

Published
2020
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40. Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study

Author

Maisonneuve, Emeline, primary, Lorthe, Elsa, additional, Torchin, Héloïse, additional, Delorme, Pierre, additional, Devisme, Louise, additional, L’Hélias, Laurence Foix, additional, Marret, Stéphane, additional, Subtil, Damien, additional, Bodeau-Livinec, Florence, additional, Pierrat, Véronique, additional, Sentilhes, Loïc, additional, Goffinet, François, additional, Ancel, Pierre-Yves, additional, Kayem, Gilles, additional, Arnaud, Catherine, additional, Arthuis, Chloé, additional, Blanc, Julie, additional, Boileau, Pascal, additional, Debillon, Thierry, additional, D’Ercole, Claude, additional, Desplanches, Thomas, additional, Diguisto, Caroline, additional, Garbi, Aurélie, additional, Gascoin, Géraldine, additional, Gire, Catherine, additional, Langer, Bruno, additional, Letouzey, Mathilde, additional, Monier, RM, Isabelle, additional, Morgan, Andrei, additional, Rozé, Jean-Christophe, additional, Schmitz, Thomas, additional, Tosello, Barthélémy, additional, Vayssiére, Christophe, additional, Winer, Norbert, additional, and Zeitlin, Jennifer, additional

Published
2020
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44. Prenatal parental involvement in decision for delivery room management at 22-26 weeks of gestation in France - The EPIPAGE-2 Cohort Study

Author

Levaillant, Cerise, Caeymaex, Laurence, Behal, Hélène, Kaminski, Monique, Diguisto, Caroline, Tosello, Barthélémy, Azria, Elie, Claris, Olivier, Bétrémieux, Pierre, Foix L'Hélias, Laurence, Truffert, Patrick, Gestionnaire, Hal Sorbonne Université, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Intercommunal de Créteil (CHIC), Centre d'Etudes des discours, Images, Textes, Ecrits, Communications (CEDITEC), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Lille, Université Sorbonne Paris Cité (USPC), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Aix Marseille Université (AMU), EFS, Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, CHU Pontchaillou [Rennes], Service de néonatologie [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Trousseau [APHP], CHU Lille, Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Centre d'Etudes des discours, Images, Textes, Ecrits, Communications [CEDITEC], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique [CRESS - U1153], Université Claude Bernard Lyon 1 [UCBL], Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Groupe hospitalier Paris Saint-Joseph - Hôpital, and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP]-Sorbonne Université (SU)

Subjects
Male, Parents, Critical Care and Emergency Medicine, Physiology, Maternal Health, Resuscitation, Decision Making, Social Sciences, Gestational Age, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Pediatrics, Families, Labor and Delivery, Cognition, Pregnancy, Medicine and Health Sciences, Humans, Psychology, Birth Weight, Public Health Surveillance, Children, Delivery Rooms, Body Weight, Infant, Newborn, Cognitive Psychology, Disease Management, Infant, Biology and Life Sciences, Neonates, Obstetrics and Gynecology, Delivery, Obstetric, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Physiological Parameters, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Age Groups, Infant, Extremely Premature, People and Places, Birth, Cognitive Science, Women's Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Population Groupings, France, Infants, Research Article, Developmental Biology, Neuroscience
Abstract

International audience; OBJECTIVE: Our main objective was to examine if parental prenatal preferences predict delivery-room management of extremely preterm periviable infants. The secondary objectives were to describe parental involvement and the content of prenatal counseling given to parents for this prenatal decision.DESIGN: Prospective study of neonates liveborn between 22 and 26 weeks of gestation in France in 2011 among the neonates included in the EPIPAGE-2 study.SETTING: 18 centers participating in the "Extreme Prematurity Group" substudy of the EPIPAGE-2 study.PATIENTS: 302 neonates liveborn between 22-26 weeks among which 113 with known parental preferences while parental preferences were unknown or unavailable for 186 and delivery room management was missing for 3.RESULTS: Data on prenatal counseling and parental preferences were collected by a questionnaire completed by professionals who cared for the baby at birth; delivery room (DR) management, classified as stabilization or initiation of resuscitation (SIR) vs comfort care (CC). The 113 neonates studied had a mean (SD) gestational age of 24 (0.1) weeks. Parents of neonates in the CC group preferred SIR less frequently than those with neonates in the SIR group (16% vs 88%, p < .001). After multivariate analysis, preference for SIR was an independent factor associated with this management. Professionals qualified decisions as shared (81%), exclusively medical (16%) or parental (3%). Information was described as medical with no personal opinion (71%), complete (75%) and generally pessimistic (54%).CONCLUSION: Parental involvement in prenatal decision-making did not reach satisfying rates in the studied setting. When available, prenatal parental preference was a determining factor for DR management of extremely preterm neonates. Potential biases in the content of prenatal counselling given to parents need to be evaluated.

Published
2019

45. Additional file 1 of Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study

Author

Morgan, Andrei S., L’Helias, Laurence Foix, Diguisto, Caroline, Marchand-Martin, Laetitia, Kaminski, Monique, Khoshnood, Babak, Zeitlin, Jennifer, Bréart, Gérard, Durrmeyer, Xavier, Goffinet, François, and Pierre-Yves Ancel

Subjects
body regions, nervous system, fungi, digestive system, digestive system diseases
Abstract

S1 Appendix. Creating a ratio to measure intensity of active perinatal care. (PDF 143 kb)

Published
2018
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46. Additional file 3 of Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study

Author

Morgan, Andrei S., L’Helias, Laurence Foix, Diguisto, Caroline, Marchand-Martin, Laetitia, Kaminski, Monique, Khoshnood, Babak, Zeitlin, Jennifer, Bréart, Gérard, Durrmeyer, Xavier, Goffinet, François, and Pierre-Yves Ancel

Subjects
body regions, nervous system, fungi, digestive system, digestive system diseases
Abstract

S3 Appendix. Results from sensitivity analyses using populations delivered at 24–26 weeks gestation. (PDF 108 kb)

Published
2018
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48. Additional file 2 of Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study

Author

Morgan, Andrei S., L’Helias, Laurence Foix, Diguisto, Caroline, Marchand-Martin, Laetitia, Kaminski, Monique, Khoshnood, Babak, Zeitlin, Jennifer, Bréart, Gérard, Durrmeyer, Xavier, Goffinet, François, and Pierre-Yves Ancel

Abstract

S2 Appendix. Methods for multiple imputation. (PDF 84 kb)

Published
2018
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49. Association between extremely preterm caesarean delivery and maternal depressive and anxious symptoms: a national population‐based cohort study.

Author

Blanc, J, Rességuier, N, Lorthe, E, Goffinet, F, Sentilhes, L, Auquier, P, Tosello, B, d'Ercole, C, Ancel, Pierre‐Yves, Arnaud, Catherine, Blanc, Julie, Boileau, Pascal, Debillon, Thierry, Delorme, Pierre, D'Ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Foix‐L'Hélias, Laurence, Garbi, Aurélie, and Gascoin, Géraldine

Abstract

Objective: To evaluate whether caesarean delivery before 26 weeks of gestation was associated with symptoms of depression and anxiety in mothers in comparison with deliveries between 26 and 34 weeks. Design: Prospective national population‐based EPIPAGE‐2 cohort study. Setting: 268 neonatology departments in France, March to December 2011. Population: Mothers who delivered between 22 and 34 weeks and whose self‐reported symptoms of depression (Center for Epidemiologic Studies Depression Scale: CES‐D) and anxiety (State‐Trait Anxiety Inventory: STAI) were assessed at the moment of neonatal discharge. Methods: The association of caesarean delivery before 26 weeks with severe symptoms of depression (CES‐D ≥16) and anxiety (STAI ≥45) was assessed by weighted and design‐based log‐linear regression model. Main outcome measures: Severe symptoms of depression and anxiety in mothers of preterm infants. Results: Among the 2270 women completing CES‐D and STAI questionnaires at the time of neonatal discharge, severe symptoms of depression occurred in 25 (65.8%) women having a caesarean before 26 weeks versus in 748 (50.6%) women having a caesarean after 26 weeks. Caesarean delivery before 26 weeks was associated with severe symptoms of depression compared with caesarean delivery after 26 weeks (adjusted relative risk [aRR] 1.42, 95% CI 1.12–1.81) adjusted to neonatal birthweight and severe neonatal morbidity among other factors. There was no evidence of an association between mode of delivery and symptoms of anxiety. Conclusions: Mothers having a caesarean delivery before 26 weeks' gestation are at high risk of symptoms of depression and may benefit from specific preventive care. Mothers having caesarean delivery before 26 weeks' gestation are at high risk of symptoms of depression. Mothers having caesarean delivery before 26 weeks' gestation are at high risk of symptoms of depression. [ABSTRACT FROM AUTHOR]

Published
2021
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50. The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: the EPIPAGE-2 cohort study.

Author

Tosello, B, Garbi, A, Blanc, J, Lorthe, E, Foix‐L'Hélias, L, D'Ercole, C, Winer, N, Subtil, D, Goffinet, F, Kayem, G, Resseguier, N, Gire, C, Ancel, Pierre‐Yves, Arnaud, Catherine, Boileau, Pascal, Debillon, Thierry, Delorme, Pierre, Desplanches, Thomas, Diguisto, Caroline, and Gascoin, Géraldine

Subjects
PREGNANCY outcomes, HIGH-risk pregnancy, FETOFETAL transfusion, TWINS, INTENSIVE care units, COHORT analysis, PREMATURE infant diseases, AGE distribution, CHORION, SYMPTOMS, PLACENTA, LONGITUDINAL method, MULTIPLE pregnancy
Abstract

Objective: To compare the short- and mid-term outcomes of preterm twins by chorionicity of pregnancy.Design: Prospective nationwide population-based EPIPAGE-2 cohort study.Setting: 546 maternity units in France, between March and December 2011.Population: A total of 1700 twin neonates born between 24 and 34 weeks of gestation.Methods: The association of chorionicity with outcomes was analysed using multivariate regression models.Main Outcome Measures: First, survival at 2-year corrected age with or without neurosensory impairment, and second, perinatal, short-, and mid-term outcomes (survival at discharge, survival at discharge without severe morbidity) were described and compared by chorionicity.Results: In the EPIPAGE 2 cohort, 1700 preterm births were included (850 twin pregnancies). In all, 1220 (71.8%) were from dichorionic (DC) pregnancies and 480 from monochorionic (MC) pregnancies. MC pregnancies had three times more medical terminations than DC pregnancies (1.67 versus 0.51%, P < 0.001), whereas there were three times more stillbirths in MC than in DC pregnancies (10.09 versus 3.78%, P < 0.001). Both twins were alive at birth in 86.6% of DC pregnancies compared with 80.0% among MC pregnancies (P = 0.008). No significant difference according to chorionicity was found regarding neonatal deaths and morbidities. Likewise, for children born earlier than 32 weeks, the 2-year follow-up neurodevelopmental results were not significantly different between DC and MC twins.Conclusions: This study confirms that MC pregnancies have a higher risk of adverse outcomes. However, the outcomes among preterm twins admitted to neonatal intensive care units are similar irrespective of chorionicity.Tweetable Abstract: Monochorionicity is associated with adverse perinatal outcomes, but outcomes for preterm twins are comparable irrespective of their chorionicity. [ABSTRACT FROM AUTHOR]

Published
2021
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