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1,154 results on '"Di Paola R"'

1. Identification of hemodynamically stable patients with acute pulmonary embolism at high risk for death: external validation of different models

Author

Becattini, Cecilia, Gulizia, Michele M., Agnelli, Giancarlo, Dentali, Francesco, Di Lenarda, Andrea, Enea, Iolanda, Fabbri, Andrea, Maggioni, Aldo P., Pomero, Fulvio, Ruggeri, Maria Pia, Lucci, Donata, Vedovati, Maria Cristina, Duranti, Michele, Guercini, Francesco, Groff, Paolo, Verso, Melina, Fabbri, Gianna, Savoia, Martina, Baldini, Ester, Mecatti, Barbara Bartolomei, Bianchini, Francesca, Ceseri, Martina, Gonzini, Lucio, Gorini, Marco, Lorimer, Andrea, Orsini, Giampietro, Tricoli, Martina, Cimini, L.A., Becattini, C., Agnelli, G., Cesarini, V., Sanna, M., Pepe, G., Marchetti, C., Roldan, M. Olivan, Lenzi, L., Cozzio, S., Tomio, P., Diamanti, M., Beltrame, A., Glinski, L., Treleani, M., Coppa, A., Vanni, S., Bartalucci, P., Taccone, A., Costacurta, C., Bortolotti, P., Bortolussi, M., De Vecchi, M., Zanardi, F., Greco, I., Cosentini, R., Gerloni, R., Artusi, N., Cominotto, F., Sisto, U.G., Picariello, C., Roncon, L., Maddalozzo, A., Nitti, C., Riccomi, F., Buzzo, M., Bassanelli, G., Savonitto, S., Bianchi, A., Bilato, C., Lobascio, I., Dalla Valle, C., Pomata, D.P., Giostra, F., Tinuper, A.L., Zalunardo, B., Visonà, A., Panzavolta, C., Novelli, A., Bertini, A., Granai, C., Colombo, S., Periti, E., Bonacchini, L., Abrignani, M.G., Casciolo, M.F., D'Amato, A., Scardovi, A.B., Ricci, R., Iosi, S., Fontana, M.C., Marrazzo, A., Borselli, M., Di Fusco, S.A., Colivicchi, F., Enea, I., Triggiani, M., Papa, I., Pasini, G.F., Fioravanti, C., Panarello, S., Raggi, F., Marzolo, M., Cuppini, S., Milan, M., Barchetti, M., De Laura, D., Caldarola, P., Fiorini, R., Rastelli, G., Ameri, P., La Malfa, G., Cinelli, F., Sganzerla, P.C., Ubaldi, S., Sanchez, F.A., Forgione, C., Cuccia, C., Predieri, S., Fusco, S., Mumoli, N., Porta, C., Romei, M., Lucidi, M., Romaniello, A., Volpe, M., Mogni, P., Pizzolato, E., Martino, G.P., Bitti, G., Righini, G., Bandiera, G., Pennacchio, E., Limauro, S., Dachille, A., Ignone, G., Fuscaldo, G.F., De Rosa, F.M., Vazzana, N., Chesi, G., Di Filippo, F., Pierpaoli, L., Corapi, A., Vatrano, M., Angotti, C., Baccetti, F., Harari, S.A., Luisi, F., Daghini, E., De Curtis, E., Lucà, F., Ciancia, F., Blandizzi, S., Lettica, G.V., D'Orazio, S., Cosmi, F., Zaccaroni, S., Silingardi, M., Valeriano, V., Pugliese, F.R., Murgia, A.P., Parpaglia, P. Pinna, Martinelli, L., Caponi, C., Clemente, M.A., Ciccarone, A., Bongarzoni, A., Garagiola, M., Leone, M.C., Veropalumbo, M.R., Sacco, M., Morella, P., Dorigoni, S., Peterlana, D., Di Paola, R., Felis, S., Correale, M., Brunetti, N.D., Petrelli, G., Feliziani, F.T., Mastroiacovo, D., Romualdi, R., Pasin, F., Bonardi, S., Delfino, P., Scifo, C., Savioli, G., Ceresa, I.F., Galeotalanza, M., Benazzi, B., Porzio, M., Rosini, F., Ancona, C., Verrelli, C., Pasini, A. Fratta, Dalle Carbonare, L., Bozza, N., Nacci, F., Scarabelli, M.A., Amico, F., Marchesi, C., Mazzone, A., Di Tommaso, R., Cocco, F., Pezzuto, G., Luciani, A., Zamboni, P., Muriago, M., Del Pesce, L., Lucarini, A.R., Guglielmelli, E., Vannucchi, V., Moroni, F., Fichera, D., Malatino, L., Sgroi, C., Morana, I.M., Cicero, S., La Rosa, D., Mete, F., Gino, M., De Palma, A., Alessandri, M., Maestripieri, V., Battocchio, M., De Santis, M.T., Saladini, F., Corsi, D.C., Macarone Palmieri, N., Pierfranceschi, M. Giorgi, Palmonari, V., Fontanella, L., Airoldi, L., Bonocore, M., Paliani, U., Prat, L. Iogna, Chiecchi, L., Cuonzo, M., Paludo, A., Padula, D., Antonelli, A., Bicchi, M., Tota, G., Ariello, M., Sai, R., Civita, M., Tucci, M., Barbati, G., Conti, M., Cettina, R., Magnani, O., Levato, M., Gessi, V., De Rui, M., Bellizzi, A., Farneti, L., Salomone, P., Mannarini, A., Grifoni, E., Del Ghianda, S., Campodonico, J., De Cesare, N., Mutone, D., Pasoli, P., Meloni, S., Frenda, A., Viola, G., Torromeo, C., Campana, C., Pistone, M.C., Caravita, S., La Creta, C.P., Miscio, F., Loreno, M., Fenu, P., Mazzetti, M., Rossini, D., Brunacci, M., Capuano, A., Tagliamonte, G., Pinelli, M., Ballocca, F., Parca, G., Pasini, S.M., Maragno, M.G., Vecchi, F., Mancinelli, L., Cavalli, A., Di Mare, F., Conficoni, E., Miceli, R., Pecoraro, R., Fonti, C., Pegoraro, S., Piccinni, G.C., Caruso, G., Boriani, G., Lanzillotta, P., Piccolo, P., Calò, L., Stolfo, D., Mangiacapra, S., Marziali, A., Volponi, M.C., Querci, G., Terribile, R., Menabue, M., Fiorentini, A., Musci, R.L., Uras, S., Cicini, M.P., Manetti, S., Francese, G.M., Melchio, R., Scorpiglione, N., Carrara, D., Pani, A., Morisco, C., Rodolico, M., Colombo, Silvia, Vanni, Simone, Abrignani, Maurizio Giuseppe, Scardovi, Angela Beatrice, Marrazzo, Alessandra, Borselli, Matteo, Barchetti, Marco, and Maggioni, Aldo Pietro

Published
2024
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4. Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy

Author

Scuto, M., primary, Modafferi, S., additional, Rampulla, F., additional, Zimbone, V., additional, Tomasello, M., additional, Spano’, S., additional, Ontario, M.L., additional, Palmeri, A., additional, Trovato Salinaro, A., additional, Siracusa, R., additional, Di Paola, R., additional, Cuzzocrea, S., additional, Calabrese, E.J., additional, Wenzel, U., additional, and Calabrese, V., additional

Published
2022
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15. Learning climate and quality of Italian training courses in gynecology and obstetrics

Author

Sartori, E, Ghezzi, F, Cromi, A, Laganà, As, Garzon, S, Raffaelli, R, Scambia, G, Franchi, M, Italian Society of Gynecology and Obstetrics (SIGO), Candiani, M, Casarin, J, Ciavattini, A, Di Paola, R, Greco, P, Guaschino, S, Marchesoni, D, Milani, R, Rizzo, N, Venturini, Pl, Valente, E, Vizza, E, Zanconato, G, Zullo, F, Sartori, E., Ghezzi, F., Cromi, A., Lagana, A. S., Garzon, S., Raffaelli, R., Scambia, G., Franchi, M., Candiani, M., Casarin, J., Ciavattini, A., Di Paola, R., Greco, P., Guaschino, S., Marchesoni, D., Milani, R., Rizzo, N., Venturini, P. L., Valente, E., Vizza, E., Zanconato, G., and Zullo, F.

Subjects
Adult, Male, medicine.medical_specialty, Students, Medical, education, Specialty, Socio-culturale, Learning climate, Burnout, D-RECT, Gynecology, Obstetrics, Trainees, Training, Likert scale, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Surveys and Questionnaires, medicine, Humans, 030212 general & internal medicine, TUTOR, computer.programming_language, Response rate (survey), 030219 obstetrics & reproductive medicine, Descriptive statistics, business.industry, Obstetrics and Gynecology, Obstetric, Test (assessment), Trainee, Reproductive Medicine, Female, gynecology, obstetrics, training, trainees, business, D-RECT, Gynecology, Learning climate, Obstetrics, Trainees, Training, computer
Abstract

Objectives To evaluate the learning climate (LC) and quality of training in postgraduate training courses in gynecology and obstetrics in Italy, as essential element to improve the training quality of future medical specialists. Study Design Web-based anonymous survey sent to all Italian trainees in gynecology and obstetrics to assess LC and quality of postgraduate training courses. This included sociodemographic information, details regarding training positions, and a 50-item validated Dutch Residency Educational Climate Test (D-RECT) questionnaire with 11 subscales (1–5 Likert scale). At the same time, the 24-items Fifth Year Training Questionnaire (FYT-Q) was submitted to all trainees at the fifth year of training to assess quality of life (burnout and depression), quality of training and final achieved competency level. Descriptive statistics were used to describe the main characteristics of the study population and for the D-RECT and the FYT-Q results. Results One hundred seventy-eight trainees’ responses were included from 13 departments, yielding a department response rate of 33%. The mean composite score of the D-RECT was 3.185 (SD 0.305). The subscales “Formal education” and “Role of specialty tutor” scored a mean of 2.751 (SD 0.123) and 2.757 (SD 0.130), respectively. Sixty-four FYT-Q evaluations were completed. The 33% of trainees reported more than 56 weekly working hours. At least one burnout episode during the training was reported by 61% of the trainees, and the 45% of them reported one or more episode of depression. More than 50% of trainees reported adequate autonomy for gynecologic ultrasound, obstetrics first level ultrasound, hysteroscopy, and cesarean section. In FYT-Q adequacy of training, teaching, surgical teaching, and tutoring values resulted equal to or less than 3 in a 1–5 Likert scale. Conclusions D-RECT and FYT-Q questionnaires show a training that requires improvement, although the results do not seem to be completely consistent. D-RECT emphasizes the need for a better formal teaching and specialty tutors to ensure training with better LC. Interventions are needed to improve LC and quality of training in postgraduate training courses in gynecology and obstetrics in Italy.

Published
2019

16. Needlestick injuries among obstetrics and gynecology trainees: A study design to investigate an underestimated priority

Author

Scambia, G, Raffaelli, R, Baggio, S, Garzon, S, Lagana, A, Sartori, E, Vanzo, F, Vizza, E, Angioli, R, Benedetto, C, Cagnacci, A, Candiani, M, Carta, G, Caserta, D, Cherchi, P, Ciavattini, A, Cicinelli, E, Cobellis, L, Cosmi, E, D'Anna, R, De Leo, V, Di Paola, R, Di Pinto, A, Ercoli, A, Facchinetti, F, Ferrazzi, E, Frusca, T, Ghezzi, F, Greco, P, Liberati, M, Loverro, G, Nappi, L, Palumbo, M, Neri, M, Perino, A, Clemenza, S, Piccione, E, Peterlunger, I, Rizzo, N, Negri, B, Simoncini, T, Spinillo, A, Venturini, P, Vergani, P, Zullo, F, Chiantera, A, Colacurci, N, Viora, E, Franchi, M, Scambia G., Raffaelli R., Baggio S., Garzon S., Lagana A. S., Sartori E., Vanzo F., Vizza E., Angioli R., Benedetto C., Cagnacci A., Candiani M., Carta G., Caserta D., Cherchi P. L., Ciavattini A., Cicinelli E., Cobellis L., Cosmi E., D'anna R., De Leo V., Di Paola R., Di Pinto A., Ercoli A., Facchinetti F., Ferrazzi E., Frusca T., Ghezzi F., Greco P., Liberati M., Loverro G., Nappi L., Palumbo M., Neri M., Perino A., Clemenza S., Piccione E., Peterlunger I., Rizzo N., Negri B., Simoncini T., Spinillo A., Venturini P. L., Vergani P., Zullo F., Chiantera A., Colacurci N., Viora E., Franchi M., Scambia, G, Raffaelli, R, Baggio, S, Garzon, S, Lagana, A, Sartori, E, Vanzo, F, Vizza, E, Angioli, R, Benedetto, C, Cagnacci, A, Candiani, M, Carta, G, Caserta, D, Cherchi, P, Ciavattini, A, Cicinelli, E, Cobellis, L, Cosmi, E, D'Anna, R, De Leo, V, Di Paola, R, Di Pinto, A, Ercoli, A, Facchinetti, F, Ferrazzi, E, Frusca, T, Ghezzi, F, Greco, P, Liberati, M, Loverro, G, Nappi, L, Palumbo, M, Neri, M, Perino, A, Clemenza, S, Piccione, E, Peterlunger, I, Rizzo, N, Negri, B, Simoncini, T, Spinillo, A, Venturini, P, Vergani, P, Zullo, F, Chiantera, A, Colacurci, N, Viora, E, Franchi, M, Scambia G., Raffaelli R., Baggio S., Garzon S., Lagana A. S., Sartori E., Vanzo F., Vizza E., Angioli R., Benedetto C., Cagnacci A., Candiani M., Carta G., Caserta D., Cherchi P. L., Ciavattini A., Cicinelli E., Cobellis L., Cosmi E., D'anna R., De Leo V., Di Paola R., Di Pinto A., Ercoli A., Facchinetti F., Ferrazzi E., Frusca T., Ghezzi F., Greco P., Liberati M., Loverro G., Nappi L., Palumbo M., Neri M., Perino A., Clemenza S., Piccione E., Peterlunger I., Rizzo N., Negri B., Simoncini T., Spinillo A., Venturini P. L., Vergani P., Zullo F., Chiantera A., Colacurci N., Viora E., and Franchi M.

Abstract

Risk of needlestick injuries (NSIs) is high in surgical staff. Medical students and trainees have reported the highest rate of NSIs, and Obstetrics and Gynecology is considered a high-risk specialty. The risk associated to NSIs is further increased by the high prevalence of blood borne pathogens in the population. Nevertheless, the degree of concern about contraction of these serious infections has been reported significantly lower over time, showing diminishing attitudes toward prevention of exposure and lack of consideration as a major problem, in fact most of NSIs resulted unreported. Therefore, education is fundamental to change individual attitudes and behaviors, to improve awareness and increase the use of standard protections, in order to reduce the injury rate and implement reporting to hospital surveillance systems. The proposed study aims to assess NSIs in trainees currently attending residency programs in Obstetrics and Gynecology in all academic hospitals of Italy, with a standardized, pre-piloted, national-based survey. At this purpose, we developed the Obstetrics Needlestick Injury Questionnaire (ONSI-Q), a 40-items survey that will be completed via a web-based platform. The ONSI-Q investigates real incidence of NSIs, adopted protection practices, presence of associated risk factors, and attitudes and rate of the reported accidents among trainees during obstetric procedures (suture of perineal tear/episiotomy and cesarean section). These results will provide the opportunity to investigate an underestimated priority, in order to encourage educational practices with the aim to improve prevention and reporting strategies, and therefore increase occupational safety in this high-risk surgical specialty.

Published
2018

19. Effect of N-palmitoylethanolamine-oxazoline on comorbid neuropsychiatric disturbance associated with inflammatory bowel disease

Author

Cordaro, M., Scuto, M., Siracusa, R., D'Amico, R., Filippo Peritore, A., Gugliandolo, E., Fusco, R., Crupi, R., Impellizzeri, D., Pozzebon, M., Alfonsi, D., Mattei, N., Marcolongo, G., Evangelista, Maurizio, Cuzzocrea, S., Di Paola, R., Evangelista M. (ORCID:0000-0001-8438-3480), Cordaro, M., Scuto, M., Siracusa, R., D'Amico, R., Filippo Peritore, A., Gugliandolo, E., Fusco, R., Crupi, R., Impellizzeri, D., Pozzebon, M., Alfonsi, D., Mattei, N., Marcolongo, G., Evangelista, Maurizio, Cuzzocrea, S., Di Paola, R., and Evangelista M. (ORCID:0000-0001-8438-3480)

Abstract

Inflammatory bowel disease (IBD) is a chronic disorder characterized by inflammation of the gastrointestinal (GI) tract, and it is associated with different neurological disorders. Recent evidence has demonstrated that the gut-brain-axis has a central function in the perpetuation of IBS, and for this reason, it can be considered a possible therapeutic target. N-Palmitoylethanolamine-oxazoline (PEA-OXA) possesses anti-inflammatory and potent neuroprotective effects. Although recent studies have explained the neuroprotective properties of PEA-OXA, nothing is known about its effects on the gut-brain axis during colitis. The aim of this study is to explore the mechanism and the effect of PEA-OXA on the gut-brain axis in rats subjected to experimental colitis induced by oral administration of dextran sulfate sodium (DSS). Daily oral administration of PEA-OXA (10 mg/kg daily o.s.) was able to decrease the body weight loss, macroscopic damage, colon length, histological alteration, and inflammation after DSS induction. Additionally, PEA-OXA administration enhanced neurotrophic growth factor release and decreased the astroglial and microglial activation induced by DSS. Moreover, PEA-OXA restored intestinal permeability and tight junctions (TJs) as well as reduced apoptosis in the colon and brain. In our work, we demonstrated, for the first time, the action of PEA-OXA on the gut-brain axis in a model of DSS-induced colitis and its implication on the “secondary” effects associated with colonic disturbance.

Published
2020

21. Insulin modulates PC-1 processing and recruitment in cultured human cells

Author

Menzaghi, C., Di Paola, R., Baj, G., Funaro, A., Arnulfo, A., Ercolino, T., Surico, N., Malavasi, F., and Trischitta, V.

Subjects
Physiology -- Research, Insulin resistance -- Physiological aspects, Insulin resistance -- Research, Biological sciences
Abstract

We evaluated whether insulin signaling modulates plasma cell glycoprotein (PC-1) plasma membrane recruitment, posttranslational processing, and gene expression in human cultured cell lines. Insulin induced a fourfold increase (P < 0.01) of membrane PC-1 expression by rapid and sensitive mechanism(s). This effect was reduced (P < 0.05-0.01) by inhibition of phosphatidylinositol 3-kinase (200 nmolfl wortmannin) and S6 kinase (50 nmol/l rapamycin) activities and intracellular trafficking (50 [micro]mol/l monensin) and was not accompanied by PC-1 gene expression changes. Moreover, at Western blot, insulin elicited the appearance, in both plasma membrane and cytosol, of a PC-l-related 146-kDa band (in addition to bands of 163, 117, 106, and 97 kDa observed also in absence of insulin) that was sensitive to endoglycosidase H. Finally, inhibition of PC-1 translocation to plasma membrane, by wortmannin pretreatment, increases insulin-stimulated receptor autophosphorylation. Our data indicate that insulin stimulates PC-1 posttranslational processing and translocation to the plasma membrane, which in turn impairs insulin receptor signaling. Bidirectional cross talk between insulin and PC-1, therefore, takes place, which may be part of the hormone self-desensitization mechanism. insulin receptor; insulin resistance; growth factor and ectoenzyme; insulin desensitization; plasma cell glycoprotein-1

Published
2003

29. Gain of function mutations in Malate Dehydrogenase 2 (MDH2) cause familial diabetes of the adulthood

Author

Pezzilli, S, Jungtrakoon, P, Pannone, L, Marucci, A, Biagini, T, Buranasupkajorn, P, Di Paola, R, Ceron, J, Marselli, L, Marchetti, P, Mazza, T, Martinelli, S, Trischitta, V, Doria, A, and Prudente, S

Subjects
familial diabetes, familial diabetes, MODY, malate dehydrogenase 2, mitochondrial function, cell metabolism, mitochondrial function, cell metabolism, MODY, malate dehydrogenase 2
Published
2019

40. N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion

Author

Impellizzeri, D., Siracusa, R., Cordaro, M., Crupi, R., Peritore, A. F., Gugliandolo, E., D'Amico, R., Petrosino, S., Evangelista, M., Di Paola, R., Cuzzocrea, S., Evangelista M. (ORCID:0000-0001-8438-3480), Impellizzeri, D., Siracusa, R., Cordaro, M., Crupi, R., Peritore, A. F., Gugliandolo, E., D'Amico, R., Petrosino, S., Evangelista, M., Di Paola, R., Cuzzocrea, S., and Evangelista M. (ORCID:0000-0001-8438-3480)

Abstract

Aim: Recent studies revealed that pharmacological modulation of NAE-hydrolyzing acid amidase (NAAA) can be achieved with PEA oxazoline (PEA-OXA). Hence, the aim of the present work was to thoroughly evaluate the anti-inflammatory and neuroprotective effects of PEA-OXA in an experimental model of vascular dementia (VaD) induced by bilateral carotid arteries occlusion. At 24 h after VaD induction, animals were orally administered with 10 mg/kg of PEA-OXA daily for 15 days. Results: Brain tissues were handled for histological, immunohistochemical, western blot, and immunofluorescence analysis. PEA-OXA treatment evidently reduced the histological alterations and neuronal death induced by VaD and additionally improved behavioral deficits. Further, PEA-OXA decreased GFAP and Iba-1, markers of astrocytes, and microglia activation, as well as increased MAP-2, a marker of neuron development. Moreover, PEA-OXA reduced oxidative stress, modulated Nrf2-mediated antioxidant response, and inhibited the apoptotic process. Innovation: Some drugs may demonstrate their healing potential by regulating neuroinflammation, rather than by their habitually attributed actions only. Palmitoylethanolamide (PEA) is a prototype ALIAmide, well-known for its analgesic, anti-inflammatory, and neuroprotective properties. The inhibition of PEA degradation by targeting NAAA, its catabolic enzyme, is a different approach for treating neuroinflammation. This research offers new insight into the mechanism of PEA-OXA-induced neuroprotection. Conclusion: Thus, the modulation of intracellular NAAA by PEA-OXA could offer a novel means of controlling neuroinflammatory conditions associated with VaD.

Published
2019

50. The role of the peroxisome proliferator-activated receptor-α (PPAR-α) in the regulation of acute inflammation

Author

Cuzzocrea, Salvatore, Mazzon, E, DI PAOLA, R, Peli, A, Bonato, A, Britti, D, Genovese, Tiziana, Muia, C, Crisafulli, Concetta, Caputi, Achille, DI PAOLA, Rosanna, Cuzzocrea S., Mazzon E., Di Paola R., Peli A., Bonato A., Britti D., Genovese T., Muia` C., Crisafulli C., and and Caputi A. P.

Subjects
Male, medicine.medical_specialty, Fas Ligand Protein, Immunology, Peroxisome proliferator-activated receptor, Inflammation, Biology, Carrageenan, Fas ligand, Mice, Internal medicine, NEUTROPHIL INFILTRATION, medicine, Animals, Edema, Immunologic Factors, Immunology and Allergy, PPAR alpha, Receptor, Lung, Pleurisy, Mice, Knockout, chemistry.chemical_classification, CARRAGEENAN-INDUCED PAW EDEMA, Membrane Glycoproteins, Thyroid hormone receptor, Foot, Tumor Necrosis Factor-alpha, CYTOKINES, Cell Biology, Up-Regulation, Chemotaxis, Leukocyte, Disease Models, Animal, Endocrinology, Nuclear receptor, chemistry, CARRAGEENAN-INDUCED, Acute Disease, Tumor Necrosis Factors, Knockout mouse, Female, Tumor necrosis factor alpha, Inflammation Mediators, medicine.symptom, Interleukin-1, Signal Transduction
Abstract

The peroxisome proliferator-activated receptor-α (PPAR- α) is a member of the nuclear receptor superfamily of ligand-dependent transcription factors related to retinoid, steroid, and thyroid hormone receptors. The aim of the present study was to evaluate the role of the PPAR- α receptor on the development of acute inflammation. To address this question, we used two animal models of acute inflammation (carrageenan-induced paw edema and carrageenan-induced pleurisy). We report here that when compared with PPAR- α wild-type mice, PPAR- α knockout mice (PPAR- α KO) mice experienced a higher rate of the extent and severity when subjected to carrageenan injection in the paw edema model or to carrageenan administration in the pleurisy model. In particular, the absence of a functional PPAR- α gene in PPAR- α KO mice resulted in a significant augmentation of various inflammatory parameters (e.g., enhancement of paw edema, pleural exudate formation, mononuclear cell infiltration, and histological injury) in vivo. Furthermore, the absence of a functional PPAR- α gene enhanced the staining (immunohistochemistry) for FAS ligand in the paw and in the lung and the expression of tumor necrosis factor α and interleukin-1β in the lungs of carrageenan- treated mice. In conclusion, the increased inflammatory response observed in PPAR- αKO mice strongly suggests that a PPAR- α pathway modulates the degree of acute inflammation in the mice.

Published
2006

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