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1. Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials

Author

Klug, Didier, Casolla, Barbara, Puy, Laurent, Coffee, Morgane, Kuchcinski, Grégory, Labreuche, Julien, van Nieuwenhuizen, Koen M., Algra, Ale, van Gelder, Isabelle C., Kappelle, L. Jaap, Rinkel, Gabriel J.E., Schutgens, Roger E.G., Khatri, Pooja, Conwit, Robin, Falcone, Guido, Elm, Jordan, Anderson, Craig S., Song, Lili, Pandian, Jeyaraj, Hart, Robert G., Sharma, Mukul, Aref, Hany, Tarhuni, Wadea, Fabregas, Joan Marti, Diener, Hans-Christoph, Endres, Matthias, Lemmens, Robin, Kwon, Sun U., Lee, Byung-Chul, Ameriso, Sebastian, Milling, Truman J., Kasner, Scott E., Mikulik, Robert, Xavier, Denis, Beer, Ronny, Toni, Danilo, Eckstein, Jens, Seiffge, David, Ferro, Jose M., Tsivgoulis, Georgios, Sharma, Sanjib K., Wei-Liou, Chia, Hohnloser, Stefan H., Katsanos, Aristeidis, Bosch, Jackie, Healey, Jeff, Eikelboom, John, Khaw, Alexander, Gladstone, David, Pikula, Aleksandra, Coutts, Shelagh, Smith, Eric E., Butcher, Ken, Field, Thalia, Gioia, Laura, Stapf, Christian, Halse, Omid, Ringleb, Peter, Enzinger, Christian, Sibon, Igor, Montaner, Joan, Caso, Valeria, Heuschmann, Peter, Lip, Gregory Y.H., Haefeli, Walter, Debette, Stefanie, Dennis, Martin S., Wyller, Torgeir Bruun, Rønning, Ole M., Eilertsen, Helle, Ihle-Hansen, Hege, Sandset, Else Charlotte, Pennlert, Johanna, Glader, Eva-Lotta, Kruuse, Christina, Wester, Per, Carlsson, Maria, Forfang, Elisabeth, Al-Shahi Salman, Rustam, Stephen, Jacqueline, Tierney, Jayne F, Lewis, Steff C, Newby, David E, Parry-Jones, Adrian R, White, Philip M, Connolly, Stuart J, Benavente, Oscar R, Dowlatshahi, Dar, Cordonnier, Charlotte, Viscoli, Catherine M, Sheth, Kevin N, Kamel, Hooman, Veltkamp, Roland, Larsen, Kristin T, Hofmeijer, Jeannette, Kerkhoff, Henk, Schreuder, Floris H B M, Shoamanesh, Ashkan, Klijn, Catharina J M, and van der Worp, H Bart

Published
2023
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2. Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial

Author

Al-Shahi Salman, Rustam, Keerie, Catriona, Stephen, Jacqueline, Lewis, Steff, Norrie, John, Dennis, Martin S., Newby, David E., Wardlaw, Joanna M., Lip, Gregory Y.H., Parry-Jones, Adrian, White, Philip M., Baigent, Colin, Lasserson, Dan, Oliver, Colin, O'Mahony, Fiach, Amoils, Shannon, Bamford, John, Armitage, Jane, Emberson, Jonathan, Rinkel, Gabriël J.R., Lowe, Gordon, Innes, Karen, Adamczuk, Kasia, Dinsmore, Lynn, Drever, Jonathan, Milne, Garry, Walker, Allan, Hutchison, Aidan, Williams, Carol, Fraser, Ruth, Anderson, Rosemary, Covil, Kate, Stewart, Kelly, Rees, Jessica, Hall, Peter, Bullen, Alistair, Stoddart, Andrew, Moullaali, Tom J., Palmer, Jeb, Sakka, Eleni, Perthen, Joanne, Lyttle, Nicola, Samarasekera, Neshika, MacRaild, Allan, Burgess, Seona, Teasdale, Jessica, Coakley, Michelle, Taylor, Pat, Blair, Gordon, Whiteley, William, Shenkin, Susan, Clancy, Una, Macleod, Malcolm, Sutherland, Rachel, Moullaali, Tom, Barugh, Amanda, Lerpiniere, Christine, Moreton, Fiona, Fethers, Nicholas, Anjum, Tal, Krishnan, Manju, Slade, Peter, Storton, Sharon, Williams, Marie, Davies, Caroline, Connor, Lynda, Gainard, Glyn, Murphy, Carl, Barber, Mark, Esson, Derek, Choulerton, James, Shaw, Louise, Lucas, Suzanne, Hierons, Sarah, Avis, Joanne, Stone, Andrew, Gbadamoshi, Lukuman, Costa, Telma, Pearce, Lauren, Harkness, Kirsty, Richards, Emma, Howe, Jo, Kamara, Christine, Lindert, Ralf, Ali, Ali, Rehan, Jahanzeb, Chapman, Sarah, Edwards, Maria, Bathula, Raj, Cohen, David, Devine, Joseph, Mpelembue, Mushiya, Yesupatham, Priya, Chhabra, Swati, Adewetan, Gbadebo, Ballantine, Robert, Brooks, Daniel, Smith, Gemma, Rogers, Gill, Marsden, Stuart, Clark, Sarah, Wilkinson, Ami, Brown, Ellen, Stephenson, Lynsey, Nyo, Khin, Abraham, Annie, Pai, Yogish, Shim, Gek, Baliga, Vidya, Nair, Anand, Robinson, Matthew, Hawksworth, Catherine, Greig, Jill, Alam, Irfan, Nortcliffe, Tonicha, Ramiz, Ridha, Shaw, Ryan, Lee, Stephanie, Marsden, Tracy, Perez, Jane, Birleson, Emily, Yadava, Rajendra, Sangombe, Mirriam, Stafford, Sam, Hughes, Tom, Knibbs, Lucy, Morse, Bethan, Schwarz, Stefan, Jelley, Benjamin, White, Susan, Richard, Bella, Lawson, Heidi, Moseley, Sally, Tayler, Michelle, Edwards, Mandy, Triscott, Claire, Wallace, Rebecca, Hall, Angela, Dell, Amanda, Rashed, Khalid, Board, Sarah, Buckley, Clare, Tanate, Alfonso, Pitt-Kerby, Tressy, Beesley, Kate, Perry, Jess, Hellyer, Christine, Guyler, Paul, Menon, Nisha, Tysoe, Sharon, Prabakaran, Raji, Cooper, Martin, Rajapakse, Anoja, Wynter, Inez, Smith, Susan, Weir, Nic, Boxall, Cherish, Yates, Hannah, Smith, Simon, Crawford, Pamela, Marigold, James, Smith, Fiona, Harvey, Jake, Evans, Sue, Baldwin, Laura, Hammond, Sarah, Mudd, Paul, Bowring, Angela, Keenan, Samantha, Thorpe, Kevin, Haque, Mohammad, Taaffe, Joanne, Temple, Natalie, Peachey, Tracey, Wells, Kim, Haines, Fiona, Butterworth-Cowin, Nicola, Horne, Zoey, Licenik, Radim, Boughton, Hayley, England, Timothy, Hedstrom, Amanda, Menezes, Brian, Davies, Ruth, Johnson, Venetia, Whittingham-Jones, Simon, Werring, David, Obarey, Sabaa, Watchurst, Caroline, Ashton, Amy, Feerick, Shez, Francia, Nina, Banaras, Azra, Epstein, Daniel, Marinescu, Marilena, Williams, Annick, Robinson, Anna, Humphries, Fiona, Anwar, Ijaz, Annamalai, Arunkumar, Crawford, Susan, Collins, Vicky, Shepherd, Lorna, Siddle, Elaine, Penge, Justin, Qureshi, Sam, Krishnamurthy, Vinodh, Papavasileiou, Vasileios, Waugh, Dean, Veraque, Emelda, Douglas, Nathan, Khan, Numan, Ramachandran, Sankaranarayanan, Sommerville, Peter, Rudd, Anthony, Kullane, Sagal, Bhalla, Ajay, Birns, Jonathan, Ahmed, Rowshanara, Gibbons, Meegan, Klamerus, Eva, Cendreda, Benjie, Muir, Keith, Day, Nicola, Welch, Angela, Smith, Wilma, Elliot, Jennifer, Eltawil, Salwa, Mahmood, Ammad, Hatherley, Kim, Mitchell, Shirley, Bains, Harjit, Quinn, Lauren, Teal, Rachel, Gbinigie, Ivie, Harston, George, Mathieson, Phil, Ford, Gary, Schulz, Ursula, Kennedy, James, Nagaratnam, Kirubananthan, Bangalore, Kiran, Bhupathiraju, Neelima, Wharton, Chris, Fotherby, Ken, Nasar, Ahmad, Stevens, Angie, Willberry, Angela, Evans, Rachel, Rai, Baljinder, Blake, Chloe, Thavanesan, Kamy, Hann, Gail, Changuion, Tanith, Nix, Sara, Whiting, Amanda, Dharmasiri, Michelle, Mallon, Louise, Keltos, Marketa, Smyth, Nigel, Eglinton, Charlotte, Duffy, John, Tone, Ela, Sykes, Lucy, Porter, Emily, Fitton, Carolyn, Kirkineziadis, Nikolaos, Cluckie, Gillian, Kennedy, Kate, Trippier, Sarah, Williams, Rebecca, Hayter, Elizabeth, Rackie, James, Patel, Bhavini, Rita, Ghatala, Blight, Adrian, Jones, Val, Zhang, Liqun, Choy, Lillian, Pereira, Anthony, Clarke, Brian, Al-Hussayni, Samer, Dixon, Lynn, Young, Andrew, Bergin, Adrian, Broughton, David, Raghunathan, Senthil, Jackson, Benjamin, Appleton, Jason, Wilkes, Gwendoline, Buck, Amanda, Richardson, Carla, Clarke, Judith, Fleming, Lucy, Squires, Gemma, Law, Zhe, Hutchinson, Camille, Cvoro, Vera, Couser, Mandy, McGregor, Amanda, McAuley, Sean, Pound, Susan, Cochrane, Patricia, Holmes, Clare, Murphy, Peter, Devitt, Nicola, Osborn, Mairead, Steele, Amy, Guthrie, Lucy Belle, Smith, Elizabeth, Hewitt, Jonathan, Chaston, Natalie, Myint, Min, Smith, Andrew, Fairlie, Louise, Davis, Michelle, Atkinson, Beth, Woodward, Stephen, Hogg, Valerie, Fawcett, Michelle, Finlay, Louise, Dixit, Anand, Cameron, Eleanor, Keegan, Breffni, Kelly, Jim, Concannon, Dónal, Dutta, Dipankar, Ward, Deborah, Glass, Jon, O'Connell, Susan, Ngeh, Joseph, O'Kelly, Alison, Williams, Emma, Ragab, Suzanne, Jenkinson, Damian, Dube, Judith, Gleave, Laura, Leggett, Jacqui, Kissoon, Nisha, Southern, Louise, Naghotra, Utpal, Bokhari, Maria, McClelland, Beverley, Adie, Katja, Mate, Abhijit, Harrington, Frances, James, Ali, Swanson, Elizabeth, Chant, Terri, Naccache, Miriam, Coutts, Abbie, Courtauld, Gillian, Whurr, Sarah, Webber, Sue, Shead, Emily, Luder, Robert, Bhargava, Maneesh, Murali, Elodie, Cuenoud, Larissa, Pasco, Kath, Speirs, O, Chapman, Lianne, Inskip, Linda, Kavanagh, Lisa, Srinivasan, Meena, Motherwell, Nichola, Mukherjee, Indranil, Tonks, Louise, Donaldson, Denise, Button, Heather, Wilcox, Rebecca, Hurford, Fran, Logan, Rachel, Taylor, Andy, Arden, Tracie, Carpenter, Michael, Datta, Prabal, Zahoor, Tajammal, Jackson, Linda, Needle, Ann, Stanners, Andrew, Ghouri, Imran, Exley, Donna, Akhtar, Salman, Brooke, Hollie, Beadle, Shannen, O'Brien, Eoin, Francis, Jobbin, McGee, Joanne, Amis, Elaine, Mitchell, Jennifer, Finlay, Sarah, Sinha, Devesh, Manoczki, Csilla, King, Sam, Tarka, James, Choudhary, Sumita, Premaruban, Jegamalini, Sutton, Dorothy, Kumar, Pradeep, Culmsee, Charlotte, Winckley, Caroline, Davies, Holly, Thatcher, Hilary, Vasileiadis, Evangelos, Aweid, Basaam, Holden, Melinda, Mason, Cathy, Hlaing, Thant, Madzamba, Gladys, Ingram, Tanya, Linforth, Michelle, Cullen, Claire, Thomas, Nibu, France, John, Saulat, Afaq, Bhaskaran, Biju, Fitzell, Pauline, Horan, Kathleen, Manyoni, Catherine, Garfield-Smith, Josie, Griffin, Hannah, Atkins, Stacey, Redome, Joan, Muddegowda, Girish, Maguire, Holly, Barry, Adrian, Abano, Nenette, Varquez, Resti, Hiden, Joanne, Lyjko, Susan, Remegoso, Alda, Finney, Kay, Butler, Adrian, Strecker, Martin, MaCleod, Mary Joan, Irvine, Janice, Nelson, Sandra, Guzmangutierrez, German, Furnace, Jacqueline, Taylor, Vicky, Ramadan, Hawraman, Storton, Kim, Hassan, Sohail, Abdus Sami, Eman, Bellfield, Ruth, Stewart, Kelvin, Quinn, Outi, Patterson, Chris, Emsley, Hedley, Gregary, Bindu, Ahmed, Shakeel, Patel, Shakeelah, Raj, Sonia, Sultan, Sulaiman, Wright, Fiona, Langhorne, Peter, Graham, Ruth, Quinn, Terry, and McArthur, Kate

Published
2021
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3. Accuracy of healthcare systems data for identifying cardiovascular outcomes after stroke due to intracerebral haemorrhage in the United Kingdom.

Author

Hosking, Alice, Stephen, Jacqueline, Drever, Jonathan, Whiteley, William N., Sudlow, Cathie L. M., Al-Shahi Salman, Rustam, Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Dennis, Martin S, Murray, Gordon D, Newby, David E, Sandercock, Peter AG, Sprigg, Nikola, Werring, David J, and White, Phil M

Subjects
HEMORRHAGIC stroke, MAJOR adverse cardiovascular events, CEREBRAL hemorrhage, RANDOMIZED controlled trials, TREATMENT effectiveness
Abstract

Background: Healthcare systems data (HCSD) could improve the efficiency of clinical trials, but their accuracy and validity are uncertain. Our objective was to assess the accuracy of HCSD as the sole method of outcome detection in the REstart or STop Antithrombotics Randomised Trial (RESTART; ISRCTN71907627) compared with adjudicated questionnaire follow-up and compare estimates of treatment effect. Methods: RESTART was a prospective, open, assessor-blind, parallel-group randomised controlled trial (RCT) of antiplatelet therapy after intracerebral haemorrhage (ICH) in the UK. We included 496 (92%) of 537 RESTART participants, who were resident in England or Scotland at randomisation. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. RESTART used annual questionnaires to detect its primary outcome (recurrent ICH) and secondary outcome (a composite of haemorrhagic or ischemic major adverse cardiovascular events [MACE]) over a median of 2.0 years; an independent adjudication committee verified outcomes using medical records and brain imaging. We obtained ICD10-coded HCSD on hospital admissions and deaths in England and Scotland to identify primary and secondary outcomes. We compared HCSD with a reference standard of adjudicated outcomes. We estimated the effects of antiplatelet therapy using HCSD alone in a Cox proportional hazards model adjusted for minimisation variables. Results: In the original RESTART trial, 31 people experienced a primary outcome event. HCSD had sensitivity of 84% (95% CI 66 to 95%) and positive predictive value of 68% (51 to 82%) for recurrent ICH. HCSD estimated an effect of antiplatelet therapy (adjusted hazard ratio [aHR] 0.51, 95% CI 0.27 to 0.98; p = 0.044) that was almost identical to adjudicated outcomes (aHR 0.51, 95% CI 0.25 to 1.03; p = 0.060). HCSD had sensitivity of 84% (76 to 91%) and positive predictive value of 78% (69 to 85%) for MACE, on which HCSD estimated an effect of antiplatelet therapy (aHR 0.81, 95% CI 0.56 to 1.16; p = 0.247) that was similar to adjudicated outcomes (aHR 0.65, 95% CI 0.44 to 0.95; p = 0.025). Conclusions: In a RCT of antiplatelet therapy for people with ICH, HCSD was reasonably accurate and provided similar estimates of treatment effect compared with adjudicated outcomes. Trial registration: ISRCTN71907627. Registered on 25 April 2013. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Author

Hankey, Graeme J., Hackett, Maree L., Almeida, Osvaldo P., Flicker, Leon, Mead, Gillian E., Dennis, Martin S., Etherton-Beer, Christopher, Ford, Andrew H., Billot, Laurent, Jan, Stephen, Lung, Thomas, Murray, Veronica, Lundström, Erik, Anderson, Craig S., Herbert, Robert, Carter, Gregory, Donnan, Geoffrey A., Nguyen, Huy-Thang, Gommans, John, Yi, Qilong, Li, Qiang, Bompoint, Severine, Barrett, Sarah, Claxton, Anne, O'Dea, Julia, Tang, Michelle, Williams, Clare, Peterson, Shenae, Drummond, Christie, Hong, Uyen-Ha, Le, Linh-Thi My, Ngo, Tram-Thi Bich, Mai, Yen-Bao, Han, Huyen-Thanh, Truong, Nhu-Quynh, Nguyen, Huong-Thi, Ngo, Hai-Thanh, Nguyen, -Thi Binh, Ha, Oanh-Thi Kieu, Nguyen, Trang-Le Huyen, Lindley, Richard I., New, Peter, Lee, Andrew, Tran, Thanh-Trung, Le, Loan-Tran Truc Mai, Kieu, Thuy-Le Vu, Nguyen, Sang-Van, Nguyen, Thuy-Anh Diem, Dang, Tam-Nhat, Phan, Hanh-Thi Truc, Vo, Loan-Thi Ngoc, Nguyen, Mai-Hue, Dang, Hanh-Cao, Tran, Hong-Thi, Dam, Linh-Thi Cam, Ngo, Trinh-Thi Kim, Pham, Thai-Nguyen Thanh, Pham, Binh-Nguyen, Dao, Nha-Thi Thanh, Nguyen, Huong-Thi Bich, Le, Linh-Thi Cam, Do, Chi-Minh, Huynh, Huy-Quoc, Tran, Giau-Thi Kim, Le, Oanh-Thi, Tran, Ly-Thi Khanh, Duong, Chinh-Dinh, Kieu, Duong-Van, Le, Na, Nguyen, Hoa-Ngoc, Le, Binh-Van, Nguyen, Long-Thanh, Nguyen, Long-Van, Dinh, Tuan-Quoc, Vo, Tan-Van, Bui, Tram-Ngoc, Hoang, Uyen-Thi To, Nguyen, Hien-Thi Bich, Nguyen, Ha-Thi Thu, Lam, Nga-Thuy, Le, Khanh-Kim, Trinh, Phuong-Thanh, Huynh, Hop-Quang, Nguyen, Thao-Thi Thu, Lu, Huyen-Ngoc, Pham, Tham-Hong, Nguyen, Sam-Hoanh, Le, Ninh-Hong, Nguyen, Giang-Truong, Doan, Bich-Thi, Pham, Sung-Phuoc, Luong, Duong-Huu, Mai, Ha-Van, Tran, Thuc-Van, Do, Phuong-Thi, Le, Hoai-Thi, Nguyen, Chi-Van, Nguyen, Phuong-Doan, Mai, Ton-Duy, Dao, Phuong-Viet, Nguyen, Dung-Tien, Khuong, Dai-Quoc, Vuong, Trung-Xuan, Vu, Lan-Tuong, Ngo, Ngoc-Duc, Dang, Hanh-Hong, Truong, Phuong-Thai, Le, Ngan-Thi, Hoang, Hoa-Van, Do, Chung-Quang, Nguyen, Minh-Thao, Dam, Anh-Hai, Le, Quynh-Nhu, Nguyen, Ngoc-Hoang, Nguyen, Tuyen-Van, Le, Toan-Dinh, Dinh, Ha-Thi Hai, Pham, Cuong-Van, Thach, Khanh-Thi Ngoc, Nguyen, Linh-Hai, Nguyen, Loan-Thi, Le, Vien-Chi, Tran, Phuong-Hong, Nguyen, Tai-Anh, Le, Tuan-Van, Truong, Luyen-Van, Bui, Tue-Chau, Huynh, Ngoc-Xuan, Dinh, Lap-Van, Pham, An-Gia, Le, Trang-Thi Huyen, Nguyen, Vy-Tuong, Nguyen, Yen-Hai, Nguyen, Thang-Ba, Thai, Huy, Pham, Quyen-Thi Ngoc, Dao, Khoa-Duy, Pham, Quoc-Nguyen Bao, Dang, Thuong-Thi Huyen, Dinh, Huong-Huynh To, Tong, Trang-Mai, Vu, Thuy-Thi, Le, Si-Tri, Tran, Tai-Ngoc, Tran, Phuong-Hoai, Dinh, Ngoc-Thuy Nhu, Nguyen, Binh-Thanh, Do, Vinh-Phuong, Nguyen, Anh-Ngoc, Nguyen, Binh-Thi Thanh, Blacker, David, Bunce, Lindsey, Tan, Ai Ling, Ghia, Darshan, Edmonds, Gillian, O'Loughlin, Nicole, Ewing, Megan, Whittaker, Kerri-Ann, Deane, Lorralee, Gawarikar, Yash, Jones, Brett, Lopez, Maria, Nagesh, Koushik, Siracusa, Emma, Davis, Stephen, McDonald, Amy, Tsoleridis, Jess, McCoy, Rachael, Jackson, David, Silver, Gab, Bates, Timothy R., Boudville, Amanda, Southwell, Lynda, Cordato, Dennis, McDougall, Alan J., Cappelen-Smith, Cecilia, Calic, Zeljka, Askar, Shabeel, Cheng, Qi, Kumar, Raymond, Geraghty, Richard, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, McLennan, Cassandra, Sahathevan, Ramesh, Hair, Casey, Levy, Stanley, Macdonald, Beverley, Nham, Benjamin, Rigney, Louise, Nathani, Dev, Gopinath, Sumana, Patel, Vishal, Mamun, Abul, Trewin, Benjamin, Phua, Chun, Choong, Ho, Tarrant, Lauren, Boyle, Kerry, Hewitt, Luisa, Hourn, Monique, Masterson, Amanda, Oakley, Kim, Ruddell, Karen, Sanctuary, Colette, Veitch, Kimberley, Burdusel, Camelia, Lee, Lina, Cheuk, Gary, Christley, Jeremy, Hartwell, Tabitha, Davenport, Craig, Hickey, Kate, Robertson, Rosanna, Carr, Michelle, Akbari, Sam, Coyle, Hannah, O'Neill, Megan, Redpath, Cameron, Roberts, Caroline, Tabesh, Marjan, Withiel, Toni, Abeysuriya, Kapila, Granger, Andrew, Abraham, Angela, Chua, Chermaine, Do Nguyen, Dung, Surendran, Vathani, Daines, Melissa, Shivlal, David, Latif, Mudassar, Mughal, Noreen, Morgan, Patricia, Krause, Martin, Priglinger, Miriam, Shandiz, Ehsan E., Day, Susan, Kho, Lay, Pollack, Michael, Dunne, Judith, Baines, Helen, Rees, Merridie, White, Jenni, Withanage, Aicuratiya, Delcourt, Candice, Carcel, Cheryl, Malavera, Alejandra, Kunchok, Amy, Ray, Elizabeth, Pepper, Elizabeth, Duckett, Emily, Ormond, Sally, Moey, Andrew, Kleinig, Timothy, Maxwell, Vanessa, Baldwin, Chantal, Vallat, Wilson, Field, Deborah, Markus, Romesh, Page, Kirsty, Wheelwright, Danielle, Bolitho, Sam, Faux, Steven, Sangvatanakul, Fix, Brown, Alexis, Walker, Susan, Massey, Jennifer, Hayes, Hillary, Katrak, Pesi, Winker, Annie, Zagami, Alessandro, Bailey, Alanah, Mccormack, Sarah, Murray, Andrew, Rollason, Mark, Taylor, Christopher, O'Rourke, Fintan, Kuang, Ye Min, Burnet, Heike, Liu, Yvonne, Wu, Aileen, Ramirez, Diana, Wijeratne, Tissa, Celestino, Sherisse, Low, Essie, Chen, Cynthia, Bergqvist, Jennifer, Evans, Andrew, Leung, Queenie, Jude, Martin, McQueen, Rachael, Mohr, Katherine, Kernaghan, Latitia, Stockle, Paul, Tan, Boon L., Laubscher, Sara, Schmid, Diana, Spooner, Melissa, Lallu, Bhavesh, Pepperell, Bronwen, Chalissery, John, Mahawish, Karim, DeCaigney, Susan, Broughton, Paula, Knight, Karen, Duque, Veronica, McNaughton, Harry, Lanford, Jeremy, Fu, Vivian, and Wong, Lai-Kin

Published
2020
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5. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Author

Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, Mitra, Dipayan, Bhatnagar, Priya, du Plessis, Johannes, Joshi, Yogish, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Sprigg, Nikola, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dennis, Martin, Sudlow, Cathie, Whiteley, William, Al-Shahi Salman, Rustam, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, Thomas, Kelly, Minks, David P, Rodrigues, Mark A, du Plessis, Johann C, Dennis, Martin S, Murray, Gordon D, Newby, David E, Sandercock, Peter A G, Stephen, Jacqueline, Sudlow, Cathie L M, Werring, David J, Whiteley, William N, Wardlaw, Joanna M, and White, Philip M

Published
2019
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6. Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials

Author

Al-Shahi Salman, Rustam, primary, Stephen, Jacqueline, additional, Tierney, Jayne F, additional, Lewis, Steff C, additional, Newby, David E, additional, Parry-Jones, Adrian R, additional, White, Philip M, additional, Connolly, Stuart J, additional, Benavente, Oscar R, additional, Dowlatshahi, Dar, additional, Cordonnier, Charlotte, additional, Viscoli, Catherine M, additional, Sheth, Kevin N, additional, Kamel, Hooman, additional, Veltkamp, Roland, additional, Larsen, Kristin T, additional, Hofmeijer, Jeannette, additional, Kerkhoff, Henk, additional, Schreuder, Floris H B M, additional, Shoamanesh, Ashkan, additional, Klijn, Catharina J M, additional, van der Worp, H Bart, additional, Klug, Didier, additional, Casolla, Barbara, additional, Puy, Laurent, additional, Coffee, Morgane, additional, Kuchcinski, Grégory, additional, Labreuche, Julien, additional, van Nieuwenhuizen, Koen M., additional, Algra, Ale, additional, van Gelder, Isabelle C., additional, Kappelle, L. Jaap, additional, Rinkel, Gabriel J.E., additional, Schutgens, Roger E.G., additional, Khatri, Pooja, additional, Conwit, Robin, additional, Falcone, Guido, additional, Elm, Jordan, additional, Anderson, Craig S., additional, Song, Lili, additional, Pandian, Jeyaraj, additional, Hart, Robert G., additional, Sharma, Mukul, additional, Aref, Hany, additional, Tarhuni, Wadea, additional, Fabregas, Joan Marti, additional, Diener, Hans-Christoph, additional, Endres, Matthias, additional, Lemmens, Robin, additional, Kwon, Sun U., additional, Lee, Byung-Chul, additional, Ameriso, Sebastian, additional, Milling, Truman J., additional, Kasner, Scott E., additional, Mikulik, Robert, additional, Xavier, Denis, additional, Beer, Ronny, additional, Toni, Danilo, additional, Eckstein, Jens, additional, Seiffge, David, additional, Ferro, Jose M., additional, Tsivgoulis, Georgios, additional, Sharma, Sanjib K., additional, Wei-Liou, Chia, additional, Hohnloser, Stefan H., additional, Katsanos, Aristeidis, additional, Bosch, Jackie, additional, Healey, Jeff, additional, Eikelboom, John, additional, Khaw, Alexander, additional, Gladstone, David, additional, Pikula, Aleksandra, additional, Coutts, Shelagh, additional, Smith, Eric E., additional, Butcher, Ken, additional, Field, Thalia, additional, Gioia, Laura, additional, Stapf, Christian, additional, Halse, Omid, additional, Ringleb, Peter, additional, Enzinger, Christian, additional, Sibon, Igor, additional, Montaner, Joan, additional, Caso, Valeria, additional, Heuschmann, Peter, additional, Lip, Gregory Y.H., additional, Haefeli, Walter, additional, Debette, Stefanie, additional, Dennis, Martin S., additional, Wyller, Torgeir Bruun, additional, Rønning, Ole M., additional, Eilertsen, Helle, additional, Ihle-Hansen, Hege, additional, Sandset, Else Charlotte, additional, Pennlert, Johanna, additional, Glader, Eva-Lotta, additional, Kruuse, Christina, additional, Wester, Per, additional, Carlsson, Maria, additional, and Forfang, Elisabeth, additional

Published
2023
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15. The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial

Author

Al-Shahi Salman, Rustam, Dennis, Martin S., Murray, Gordon D., Innes, Karen, Drever, Jonathan, Dinsmore, Lynn, Williams, Carol, White, Philip M., Whiteley, William N., Sandercock, Peter A. G., Sudlow, Cathie L. M., Newby, David E., Sprigg, Nikola, Werring, David J., and the RESTART collaborators

Published
2018
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20. Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage: Extended Follow-up of the RESTART Randomized Clinical Trial

Author

Al-Shahi Salman, Rustam, Dennis, Martin S, Sandercock, Peter A G, Sudlow, Cathie L M, Wardlaw, Joanna M, Whiteley, William N, Murray, Gordon D, Stephen, Jacqueline, Rodriguez, Aryelly, Lewis, Steff, Werring, David J, White, Phil M, RESTART Collaboration, and Rajkumar, Chakravarthi

Subjects
Male, medicine.medical_specialty, Randomization, law.invention, Randomized controlled trial, Fibrinolytic Agents, Interquartile range, law, Recurrence, Internal medicine, Antithrombotic, medicine, Online First, Humans, cardiovascular diseases, Stroke, Original Investigation, Aged, Cerebral Hemorrhage, Intracerebral hemorrhage, Aged, 80 and over, business.industry, Research, Hazard ratio, medicine.disease, Cerebrovascular Disorders, Female, Neurology (clinical), business, Comments, Fibrinolytic agent, Platelet Aggregation Inhibitors, Follow-Up Studies
Abstract

Key Points Question What are the long-term effects of antiplatelet therapy after stroke caused by intracerebral hemorrhage in patients who were in the pilot phase of the Restart or Stop Antithrombotics Randomized Trial? Findings In this randomized clinical trial of 537 participants with extended follow-up for a median total of 3.0 years (interquartile range, 2.0-5.0 years), the proportion of participants with intracerebral hemorrhage recurrence was 8.2% after allocation to start antiplatelet therapy and 9.3% without antiplatelet therapy, a nonsignificant difference. There were nonsignificantly fewer major vascular events among individuals in the group taking antiplatelet therapy vs the group avoiding antiplatelet therapy (26.8% vs 32.5%). Meaning After intracerebral hemorrhage associated with antithrombotic drug use, antiplatelet therapy appears to be safe., Importance The Restart or Stop Antithrombotics Randomized Trial (RESTART) found that antiplatelet therapy appeared to be safe up to 5 years after intracerebral hemorrhage (ICH) that had occurred during antithrombotic (antiplatelet or anticoagulant) therapy. Objectives To monitor adherence, increase duration of follow-up, and improve precision of estimates of the effects of antiplatelet therapy on recurrent ICH and major vascular events. Design, Setting and Participants From May 22, 2013, through May 31, 2018, this prospective, open, blinded end point, parallel-group randomized clinical trial studied 537 participants at 122 hospitals in the UK. Participants were individuals 18 years or older who had taken antithrombotic therapy for the prevention of occlusive vascular disease when they developed ICH, discontinued antithrombotic therapy, and survived for 24 hours. After initial follow-up ended on November 30, 2018, annual follow-up was extended until November 30, 2020, for a median of 3.0 years (interquartile range [IQR], 2.0-5.0 years) for the trial cohort. Interventions Computerized randomization that incorporated minimization allocated participants (1:1) to start or avoid antiplatelet therapy. Main Outcomes and Measures Participants were followed up for the primary outcome (recurrent symptomatic ICH) and secondary outcomes (all major vascular events) for up to 7 years. Data from all randomized participants were analyzed using Cox proportional hazards regression, adjusted for minimization covariates. Results A total of 537 patients (median age, 76.0 years; IQR, 69.0-82.0 years; 360 [67.0%] male; median time after ICH onset, 76.0 days; IQR, 29.0-146.0 days) were randomly allocated to start (n = 268) or avoid (n = 269 [1 withdrew]) antiplatelet therapy. The primary outcome of recurrent ICH affected 22 of 268 participants (8.2%) allocated to antiplatelet therapy compared with 25 of 268 participants (9.3%) allocated to avoid antiplatelet therapy (adjusted hazard ratio, 0.87; 95% CI, 0.49-1.55; P = .64). A major vascular event affected 72 participants (26.8%) allocated to antiplatelet therapy compared with 87 participants (32.5%) allocated to avoid antiplatelet therapy (hazard ratio, 0.79; 95% CI, 0.58-1.08; P = .14). Conclusions and Relevance Among patients with ICH who had previously taken antithrombotic therapy, this study found no statistically significant effect of antiplatelet therapy on recurrent ICH or all major vascular events. These findings provide physicians with some reassurance about the use of antiplatelet therapy after ICH if indicated for secondary prevention of major vascular events. Trial Registration isrctn.org Identifier: ISRCTN71907627, A follow-up of the Restart or Stop Antithrombotics Randomized Trial, this study further examines the long-term effects of antiplatelet therapy after stroke caused by intracerebral hemorrhage.

Published
2021
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32. Assessing The Quality Of Care

Author

Davenport, Richard J., Dennis, Martin S., Lakhani, Mayur, Baker, Richard, and Fraser, Robin

Published
1996

36. Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration

Author

Hankey, Graeme J., primary, Hackett, Maree L., additional, Almeida, Osvaldo P., additional, Flicker, Leon, additional, Mead, Gillian E., additional, Dennis, Martin S., additional, Etherton-Beer, Christopher, additional, Ford, Andrew H., additional, Billot, Laurent, additional, Jan, Stephen, additional, Lung, Thomas, additional, Lundström, Erik, additional, Sunnerhagen, Katharina S., additional, Anderson, Craig S., additional, Thang-Nguyen, Huy, additional, Gommans, John, additional, Yi, Qilong, additional, Murray, Veronica, additional, Herbert, Robert, additional, Carter, Gregory, additional, Donnan, Geoffrey A., additional, Nguyen, Huy-Thang, additional, Li, Qiang, additional, Bompoint, Severine, additional, Barrett, Sarah, additional, Claxton, Anne, additional, O’Dea, Julia, additional, Tang, Michelle, additional, Williams, Clare, additional, Peterson, Shenae, additional, Drummond, Christie, additional, Hong, Uyen-Ha, additional, My Le, Linh-Thi, additional, Bich Ngo, Tram-Thi, additional, Mai, Yen-Bao, additional, Han, Huyen-Thanh, additional, Truong, Nhu-Quynh, additional, Nguyen, Huong-Thi, additional, Ngo, Hai-Thanh, additional, Nguyen, Thi Binh, additional, Kieu Ha, Oanh-Thi, additional, Huyen Nguyen, Trang-Le, additional, Lindley, Richard I., additional, New, Peter, additional, Lee, Andrew, additional, Tran, Thanh-Trung, additional, Truc Mai Le, Loan-Tran, additional, Vu Kieu, Thuy-Le, additional, Nguyen, Sang-Van, additional, Diem Nguyen, Thuy-Anh, additional, Dang, Tam-Nhat, additional, Truc Phan, Hanh-Thi, additional, Ngoc Vo, Loan-Thi, additional, Nguyen, Mai-Hue, additional, Dang, Hanh-Cao, additional, Tran, Hong-Thi, additional, Cam Dam, Linh-Thi, additional, Kim Ngo, Trinh-Thi, additional, Thanh Pham, Thai-Nguyen, additional, Pham, Binh-Nguyen, additional, Thanh Dao, Nha-Thi, additional, Bich Nguyen, Huong-Thi, additional, Cam Le, Linh-Thi, additional, Do, Chi-Minh, additional, Huynh, Huy-Quoc, additional, Tran, Giau-Thi Kim, additional, Le, Oanh-Thi, additional, Khanh Tran, Ly-Thi, additional, Duong, Chinh-Dinh, additional, Kieu, Duong-Van, additional, Le, Na, additional, Nguyen, Hoa-Ngoc, additional, Le, Binh-Van, additional, Nguyen, Long-Thanh, additional, Nguyen, Long-Van, additional, Dinh, Tuan-Quoc, additional, Vo, Tan-Van, additional, Bui, Tram-Ngoc, additional, To Hoang, Uyen-Thi, additional, Bich Nguyen, Hien-Thi, additional, Thu Nguyen, Ha-Thi, additional, Lam, Nga-Thuy, additional, Le, Khanh-Kim, additional, Trinh, Phuong-Thanh, additional, Huynh, Hop-Quang, additional, Thu Nguyen, Thao-Thi, additional, Lu, Huyen-Ngoc, additional, Pham, Tham-Hong, additional, Nguyen, Sam-Hoanh, additional, Le, Ninh-Hong, additional, Nguyen, Giang-Truong, additional, Doan, Bich-Thi, additional, Pham, Sung-Phuoc, additional, Luong, Duong-Huu, additional, Mai, Ha-Van, additional, Tran, Thuc-Van, additional, Do, Phuong-Thi, additional, Le, Hoai-Thi, additional, Nguyen, Chi-Van, additional, Nguyen, Phuong-Doan, additional, Mai, Ton-Duy, additional, Dao, Phuong-Viet, additional, Nguyen, Dung-Tien, additional, Khuong, Dai-Quoc, additional, Vuong, Trung-Xuan, additional, Vu, Lan-Tuong, additional, Ngo, Ngoc-Duc, additional, Dang, Hanh-Hong, additional, Truong, Phuong-Thai, additional, Le, Ngan-Thi, additional, Hoang, Hoa-Van, additional, Do, Chung-Quang, additional, Nguyen, Minh-Thao, additional, Dam, Anh-Hai, additional, Le, Quynh-Nhu, additional, Nguyen, Ngoc-Hoang, additional, Nguyen, Tuyen-Van, additional, Le, Toan-Dinh, additional, Hai Dinh, Ha-Thi, additional, Pham, Cuong–Van, additional, Ngoc Thach, Khanh-Thi, additional, Nguyen, Linh-Hai, additional, Nguyen, Loan-Thi, additional, Le, Vien-Chi, additional, Tran, Phuong-Hong, additional, Nguyen, Tai-Anh, additional, Le, Tuan-Van, additional, Truong, Luyen-Van, additional, Bui, Tue-Chau, additional, Huynh, Ngoc-Xuan, additional, Dinh, Lap-Van, additional, Pham, An-Gia, additional, Huyen Le, Trang-Thi, additional, Nguyen, Vy-Tuong, additional, Nguyen, Yen-Hai, additional, Nguyen, Thang-Ba, additional, Thai, Huy, additional, Ngoc Pham, Quyen-Thi, additional, Dao, Khoa-Duy, additional, Bao Pham, Quoc-Nguyen, additional, Huyen Dang, Thuong-Thi, additional, To Dinh, Huong-Huynh, additional, Tong, Trang-Mai, additional, Vu, Thuy-Thi, additional, Le, Si-Tri, additional, Tran, Tai-Ngoc, additional, Tran, Phuong-Hoai, additional, Nhu Dinh, Ngoc-Thuy, additional, Nguyen, Binh-Thanh, additional, Do, Vinh-Phuong, additional, Nguyen, Anh-Ngoc, additional, Thanh Nguyen, Binh-Thi, additional, Blacker, David, additional, Bunce, Lindsey, additional, Tan, Ai Ling, additional, Ghia, Darshan, additional, Edmonds, Gillian, additional, O’Loughlin, Nicole, additional, Ewing, Megan, additional, Whittaker, Kerri-Ann, additional, Deane, Lorralee, additional, Gawarikar, Yash, additional, Jones, Brett, additional, Lopez, Maria, additional, Nagesh, Koushik, additional, Siracusa, Emma, additional, Davis, Stephen, additional, McDonald, Amy, additional, Tsoleridis, Jess, additional, McCoy, Rachael, additional, Jackson, David, additional, Silver, Gab, additional, Bates, Timothy R., additional, Boudville, Amanda, additional, Southwell, Lynda, additional, Cordato, Dennis, additional, McDougall, Alan J., additional, Cappelen-Smith, Cecilia, additional, Calic, Zeljka, additional, Askar, Shabeel, additional, Cheng, Qi, additional, Kumar, Raymond, additional, Geraghty, Richard, additional, Duroux, Maree, additional, Ratcliffe, Megan, additional, Shone, Samantha, additional, McLennan, Cassandra, additional, Sahathevan, Ramesh, additional, Hair, Casey, additional, Levy, Stanley, additional, Macdonald, Beverley, additional, Nham, Benjamin, additional, Rigney, Louise, additional, Nathani, Dev, additional, Gopinath, Sumana, additional, Patel, Vishal, additional, Mamun, Abul, additional, Trewin, Benjamin, additional, Phua, Chun, additional, Choong, Ho, additional, Tarrant, Lauren, additional, Boyle, Kerry, additional, Hewitt, Luisa, additional, Hourn, Monique, additional, Masterson, Amanda, additional, Oakley, Kim, additional, Ruddell, Karen, additional, Sanctuary, Colette, additional, Veitch, Kimberley, additional, Burdusel, Camelia, additional, Lee, Lina, additional, Cheuk, Gary, additional, Christley, Jeremy, additional, Hartwell, Tabitha, additional, Davenport, Craig, additional, Hickey, Kate, additional, Robertson, Rosanna, additional, Carr, Michelle, additional, Akbari, Sam, additional, Coyle, Hannah, additional, O’Neill, Megan, additional, Redpath, Cameron, additional, Roberts, Caroline, additional, Tabesh, Marjan, additional, Withiel, Toni, additional, Abeysuriya, Kapila, additional, Granger, Andrew, additional, Abraham, Angela, additional, Chua, Chermaine, additional, Nguyen, Dung Do, additional, Surendran, Vathani, additional, Daines, Melissa, additional, Shivlal, David, additional, Latif, Mudassar, additional, Mughal, Noreen, additional, Morgan, Patricia, additional, Krause, Martin, additional, Priglinger, Miriam, additional, Shandiz, Ehsan E., additional, Day, Susan, additional, Kho, Lay, additional, Pollack, Michael, additional, Dunne, Judith, additional, Baines, Helen, additional, Rees, Merridie, additional, White, Jenni, additional, Withanage, Aicuratiya, additional, Delcourt, Candice, additional, Carcel, Cheryl, additional, Malavera, Alejandra, additional, Kunchok, Amy, additional, Ray, Elizabeth, additional, Pepper, Elizabeth, additional, Duckett, Emily, additional, Ormond, Sally, additional, Moey, Andrew, additional, Kleinig, Timothy, additional, Maxwell, Vanessa, additional, Baldwin, Chantal, additional, Vallat, Wilson, additional, Field, Deborah, additional, Markus, Romesh, additional, Page, Kirsty, additional, Wheelwright, Danielle, additional, Bolitho, Sam, additional, Faux, Steven, additional, Sangvatanakul, Fix, additional, Brown, Alexis, additional, Walker, Susan, additional, Massey, Jennifer, additional, Hayes, Hillary, additional, Katrak, Pesi, additional, Winker, Annie, additional, Zagami, Alessandro, additional, Bailey, Alanah, additional, Mccormack, Sarah, additional, Murray, Andrew, additional, Rollason, Mark, additional, Taylor, Christopher, additional, O’Rourke, Fintan, additional, Kuang, Ye Min, additional, Burnet, Heike, additional, Liu, Yvonne, additional, Wu, Aileen, additional, Ramirez, Diana, additional, Wijeratne, Tissa, additional, Celestino, Sherisse, additional, Low, Essie, additional, Chen, Cynthia, additional, Bergqvist, Jennifer, additional, Evans, Andrew, additional, Leung, Queenie, additional, Jude, Martin, additional, McQueen, Rachael, additional, Mohr, Katherine, additional, Kernaghan, Latitia, additional, Stockle, Paul, additional, Tan, Boon L., additional, Laubscher, Sara, additional, Schmid, Diana, additional, Spooner, Melissa, additional, Lallu, Bhavesh, additional, Pepperell, Bronwen, additional, Chalissery, John, additional, Mahawish, Karim, additional, DeCaigney, Susan, additional, Broughton, Paula, additional, Knight, Karen, additional, Duque, Veronica, additional, McNaughton, Harry, additional, Lanford, Jeremy, additional, Fu, Vivian, additional, and Wong, Lai-Kin, additional

Published
2021
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37. Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration

Author

Hankey, Graeme J., Hackett, Maree, Almeida, Osvaldo P., Flicker, Leon, Mead, Gillian E., Dennis, Martin S., Etherton-Beer, Christopher, Ford, Andrew H., Billot, Laurent, Jan, Stephen, Lung, Thomas, Lundström, Erik, Sunnerhagen, Katharina S., Anderson, Craig S., Thang-Nguyen, Huy, Gommans, John, Yi, Qilong, Murray, Veronica, Herbert, Robert, Carter, Gregory, Donnan, Geoffrey A., Nguyen, Huy-Thang, Li, Qiang, Bompoint, Severine, Barrett, Sarah, Claxton, Anne, O’Dea, Julia, Tang, Michelle, Williams, Clare, Peterson, Shenae, Drummond, Christie, Hong, Uyen-Ha, My Le, Linh-Thi, Bich Ngo, Tram-Thi, Mai, Yen-Bao, Han, Huyen-Thanh, Truong, Nhu-Quynh, Nguyen, Huong-Thi, Ngo, Hai-Thanh, Nguyen, Thi Binh, Kieu Ha, Oanh-Thi, Huyen Nguyen, Trang-Le, Lindley, Richard I., New, Peter, Lee, Andrew, Tran, Thanh-Trung, Truc Mai Le, Loan-Tran, Vu Kieu, Thuy-Le, Nguyen, Sang-Van, Diem Nguyen, Thuy-Anh, Dang, Tam-Nhat, Truc Phan, Hanh-Thi, Ngoc Vo, Loan-Thi, Nguyen, Mai-Hue, Dang, Hanh-Cao, Tran, Hong-Thi, Cam Dam, Linh-Thi, Kim Ngo, Trinh-Thi, Thanh Pham, Thai-Nguyen, Pham, Binh-Nguyen, Thanh Dao, Nha-Thi, Bich Nguyen, Huong-Thi, Cam Le, Linh-Thi, Do, Chi-Minh, Huynh, Huy-Quoc, Tran, Giau-Thi Kim, Le, Oanh-Thi, Khanh Tran, Ly-Thi, Duong, Chinh-Dinh, Kieu, Duong-Van, Le, Na, Nguyen, Hoa-Ngoc, Le, Binh-Van, Nguyen, Long-Thanh, Nguyen, Long-Van, Dinh, Tuan-Quoc, Vo, Tan-Van, Bui, Tram-Ngoc, To Hoang, Uyen-Thi, Bich Nguyen, Hien-Thi, Thu Nguyen, Ha-Thi, Lam, Nga-Thuy, Le, Khanh-Kim, Trinh, Phuong-Thanh, Huynh, Hop-Quang, Thu Nguyen, Thao-Thi, Lu, Huyen-Ngoc, Pham, Tham-Hong, Nguyen, Sam-Hoanh, Le, Ninh-Hong, Nguyen, Giang-Truong, Doan, Bich-Thi, Pham, Sung-Phuoc, Luong, Duong-Huu, Mai, Ha-Van, Tran, Thuc-Van, Do, Phuong-Thi, Le, Hoai-Thi, Nguyen, Chi-Van, Nguyen, Phuong-Doan, Mai, Ton-Duy, Dao, Phuong-Viet, Nguyen, Dung-Tien, Khuong, Dai-Quoc, Vuong, Trung-Xuan, Vu, Lan-Tuong, Ngo, Ngoc-Duc, Dang, Hanh-Hong, Truong, Phuong-Thai, Le, Ngan-Thi, Hoang, Hoa-Van, Do, Chung-Quang, Nguyen, Minh-Thao, Dam, Anh-Hai, Le, Quynh-Nhu, Nguyen, Ngoc-Hoang, Nguyen, Tuyen-Van, Le, Toan-Dinh, Hai Dinh, Ha-Thi, Pham, Cuong–Van, Ngoc Thach, Khanh-Thi, Nguyen, Linh-Hai, Nguyen, Loan-Thi, Le, Vien-Chi, Tran, Phuong-Hong, Nguyen, Tai-Anh, Le, Tuan-Van, Truong, Luyen-Van, Bui, Tue-Chau, Huynh, Ngoc-Xuan, Dinh, Lap-Van, Pham, An-Gia, Huyen Le, Trang-Thi, Nguyen, Vy-Tuong, Nguyen, Yen-Hai, Nguyen, Thang-Ba, Thai, Huy, Ngoc Pham, Quyen-Thi, Dao, Khoa-Duy, Bao Pham, Quoc-Nguyen, Huyen Dang, Thuong-Thi, To Dinh, Huong-Huynh, Tong, Trang-Mai, Vu, Thuy-Thi, Le, Si-Tri, Tran, Tai-Ngoc, Tran, Phuong-Hoai, Nhu Dinh, Ngoc-Thuy, Nguyen, Binh-Thanh, Do, Vinh-Phuong, Nguyen, Anh-Ngoc, Thanh Nguyen, Binh-Thi, Blacker, David, Bunce, Lindsey, Tan, Ai Ling, Ghia, Darshan, Edmonds, Gillian, O’Loughlin, Nicole, Ewing, Megan, Whittaker, Kerri-Ann, Deane, Lorralee, Gawarikar, Yash, Jones, Brett, Lopez, Maria, Nagesh, Koushik, Siracusa, Emma, Davis, Stephen, McDonald, Amy, Tsoleridis, Jess, McCoy, Rachael, Jackson, David, Silver, Gab, Bates, Timothy R., Boudville, Amanda, Southwell, Lynda, Cordato, Dennis, McDougall, Alan J., Cappelen-Smith, Cecilia, Calic, Zeljka, Askar, Shabeel, Cheng, Qi, Kumar, Raymond, Geraghty, Richard, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, McLennan, Cassandra, Sahathevan, Ramesh, Hair, Casey, Levy, Stanley, Macdonald, Beverley, Nham, Benjamin, Rigney, Louise, Nathani, Dev, Gopinath, Sumana, Patel, Vishal, Mamun, Abul, Trewin, Benjamin, Phua, Chun, Choong, Ho, Tarrant, Lauren, Boyle, Kerry, Hewitt, Luisa, Hourn, Monique, Masterson, Amanda, Oakley, Kim, Ruddell, Karen, Sanctuary, Colette, Veitch, Kimberley, Burdusel, Camelia, Lee, Lina, Cheuk, Gary, Christley, Jeremy, Hartwell, Tabitha, Davenport, Craig, Hickey, Kate, Robertson, Rosanna, Carr, Michelle, Akbari, Sam, Coyle, Hannah, O’Neill, Megan, Redpath, Cameron, Roberts, Caroline, Tabesh, Marjan, Withiel, Toni, Abeysuriya, Kapila, Granger, Andrew, Abraham, Angela, Chua, Chermaine, Nguyen, Dung Do, Surendran, Vathani, Daines, Melissa, Shivlal, David, Latif, Mudassar, Mughal, Noreen, Morgan, Patricia, Krause, Martin, Priglinger, Miriam, Shandiz, Ehsan E., Day, Susan, Kho, Lay, Pollack, Michael, Dunne, Judith, Baines, Helen, Rees, Merridie, White, Jenni, Withanage, Aicuratiya, Delcourt, Candice, Carcel, Cheryl, Malavera, Alejandra, Kunchok, Amy, Ray, Elizabeth, Pepper, Elizabeth, Duckett, Emily, Ormond, Sally, Moey, Andrew, Kleinig, Timothy, Maxwell, Vanessa, Baldwin, Chantal, Vallat, Wilson, Field, Deborah, Markus, Romesh, Page, Kirsty, Wheelwright, Danielle, Bolitho, Sam, Faux, Steven, Sangvatanakul, Fix, Brown, Alexis, Walker, Susan, Massey, Jennifer, Hayes, Hillary, Katrak, Pesi, Winker, Annie, Zagami, Alessandro, Bailey, Alanah, Mccormack, Sarah, Murray, Andrew, Rollason, Mark, Taylor, Christopher, O’Rourke, Fintan, Kuang, Ye Min, Burnet, Heike, Liu, Yvonne, Wu, Aileen, Ramirez, Diana, Wijeratne, Tissa, Celestino, Sherisse, Low, Essie, Chen, Cynthia, Bergqvist, Jennifer, Evans, Andrew, Leung, Queenie, Jude, Martin, McQueen, Rachael, Mohr, Katherine, Kernaghan, Latitia, Stockle, Paul, Tan, Boon L., Laubscher, Sara, Schmid, Diana, Spooner, Melissa, Lallu, Bhavesh, Pepperell, Bronwen, Chalissery, John, Mahawish, Karim, DeCaigney, Susan, Broughton, Paula, Knight, Karen, Duque, Veronica, McNaughton, Harry, Lanford, Jeremy, Fu, Vivian, Wong, Lai-Kin, Hankey, Graeme J., Hackett, Maree, Almeida, Osvaldo P., Flicker, Leon, Mead, Gillian E., Dennis, Martin S., Etherton-Beer, Christopher, Ford, Andrew H., Billot, Laurent, Jan, Stephen, Lung, Thomas, Lundström, Erik, Sunnerhagen, Katharina S., Anderson, Craig S., Thang-Nguyen, Huy, Gommans, John, Yi, Qilong, Murray, Veronica, Herbert, Robert, Carter, Gregory, Donnan, Geoffrey A., Nguyen, Huy-Thang, Li, Qiang, Bompoint, Severine, Barrett, Sarah, Claxton, Anne, O’Dea, Julia, Tang, Michelle, Williams, Clare, Peterson, Shenae, Drummond, Christie, Hong, Uyen-Ha, My Le, Linh-Thi, Bich Ngo, Tram-Thi, Mai, Yen-Bao, Han, Huyen-Thanh, Truong, Nhu-Quynh, Nguyen, Huong-Thi, Ngo, Hai-Thanh, Nguyen, Thi Binh, Kieu Ha, Oanh-Thi, Huyen Nguyen, Trang-Le, Lindley, Richard I., New, Peter, Lee, Andrew, Tran, Thanh-Trung, Truc Mai Le, Loan-Tran, Vu Kieu, Thuy-Le, Nguyen, Sang-Van, Diem Nguyen, Thuy-Anh, Dang, Tam-Nhat, Truc Phan, Hanh-Thi, Ngoc Vo, Loan-Thi, Nguyen, Mai-Hue, Dang, Hanh-Cao, Tran, Hong-Thi, Cam Dam, Linh-Thi, Kim Ngo, Trinh-Thi, Thanh Pham, Thai-Nguyen, Pham, Binh-Nguyen, Thanh Dao, Nha-Thi, Bich Nguyen, Huong-Thi, Cam Le, Linh-Thi, Do, Chi-Minh, Huynh, Huy-Quoc, Tran, Giau-Thi Kim, Le, Oanh-Thi, Khanh Tran, Ly-Thi, Duong, Chinh-Dinh, Kieu, Duong-Van, Le, Na, Nguyen, Hoa-Ngoc, Le, Binh-Van, Nguyen, Long-Thanh, Nguyen, Long-Van, Dinh, Tuan-Quoc, Vo, Tan-Van, Bui, Tram-Ngoc, To Hoang, Uyen-Thi, Bich Nguyen, Hien-Thi, Thu Nguyen, Ha-Thi, Lam, Nga-Thuy, Le, Khanh-Kim, Trinh, Phuong-Thanh, Huynh, Hop-Quang, Thu Nguyen, Thao-Thi, Lu, Huyen-Ngoc, Pham, Tham-Hong, Nguyen, Sam-Hoanh, Le, Ninh-Hong, Nguyen, Giang-Truong, Doan, Bich-Thi, Pham, Sung-Phuoc, Luong, Duong-Huu, Mai, Ha-Van, Tran, Thuc-Van, Do, Phuong-Thi, Le, Hoai-Thi, Nguyen, Chi-Van, Nguyen, Phuong-Doan, Mai, Ton-Duy, Dao, Phuong-Viet, Nguyen, Dung-Tien, Khuong, Dai-Quoc, Vuong, Trung-Xuan, Vu, Lan-Tuong, Ngo, Ngoc-Duc, Dang, Hanh-Hong, Truong, Phuong-Thai, Le, Ngan-Thi, Hoang, Hoa-Van, Do, Chung-Quang, Nguyen, Minh-Thao, Dam, Anh-Hai, Le, Quynh-Nhu, Nguyen, Ngoc-Hoang, Nguyen, Tuyen-Van, Le, Toan-Dinh, Hai Dinh, Ha-Thi, Pham, Cuong–Van, Ngoc Thach, Khanh-Thi, Nguyen, Linh-Hai, Nguyen, Loan-Thi, Le, Vien-Chi, Tran, Phuong-Hong, Nguyen, Tai-Anh, Le, Tuan-Van, Truong, Luyen-Van, Bui, Tue-Chau, Huynh, Ngoc-Xuan, Dinh, Lap-Van, Pham, An-Gia, Huyen Le, Trang-Thi, Nguyen, Vy-Tuong, Nguyen, Yen-Hai, Nguyen, Thang-Ba, Thai, Huy, Ngoc Pham, Quyen-Thi, Dao, Khoa-Duy, Bao Pham, Quoc-Nguyen, Huyen Dang, Thuong-Thi, To Dinh, Huong-Huynh, Tong, Trang-Mai, Vu, Thuy-Thi, Le, Si-Tri, Tran, Tai-Ngoc, Tran, Phuong-Hoai, Nhu Dinh, Ngoc-Thuy, Nguyen, Binh-Thanh, Do, Vinh-Phuong, Nguyen, Anh-Ngoc, Thanh Nguyen, Binh-Thi, Blacker, David, Bunce, Lindsey, Tan, Ai Ling, Ghia, Darshan, Edmonds, Gillian, O’Loughlin, Nicole, Ewing, Megan, Whittaker, Kerri-Ann, Deane, Lorralee, Gawarikar, Yash, Jones, Brett, Lopez, Maria, Nagesh, Koushik, Siracusa, Emma, Davis, Stephen, McDonald, Amy, Tsoleridis, Jess, McCoy, Rachael, Jackson, David, Silver, Gab, Bates, Timothy R., Boudville, Amanda, Southwell, Lynda, Cordato, Dennis, McDougall, Alan J., Cappelen-Smith, Cecilia, Calic, Zeljka, Askar, Shabeel, Cheng, Qi, Kumar, Raymond, Geraghty, Richard, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, McLennan, Cassandra, Sahathevan, Ramesh, Hair, Casey, Levy, Stanley, Macdonald, Beverley, Nham, Benjamin, Rigney, Louise, Nathani, Dev, Gopinath, Sumana, Patel, Vishal, Mamun, Abul, Trewin, Benjamin, Phua, Chun, Choong, Ho, Tarrant, Lauren, Boyle, Kerry, Hewitt, Luisa, Hourn, Monique, Masterson, Amanda, Oakley, Kim, Ruddell, Karen, Sanctuary, Colette, Veitch, Kimberley, Burdusel, Camelia, Lee, Lina, Cheuk, Gary, Christley, Jeremy, Hartwell, Tabitha, Davenport, Craig, Hickey, Kate, Robertson, Rosanna, Carr, Michelle, Akbari, Sam, Coyle, Hannah, O’Neill, Megan, Redpath, Cameron, Roberts, Caroline, Tabesh, Marjan, Withiel, Toni, Abeysuriya, Kapila, Granger, Andrew, Abraham, Angela, Chua, Chermaine, Nguyen, Dung Do, Surendran, Vathani, Daines, Melissa, Shivlal, David, Latif, Mudassar, Mughal, Noreen, Morgan, Patricia, Krause, Martin, Priglinger, Miriam, Shandiz, Ehsan E., Day, Susan, Kho, Lay, Pollack, Michael, Dunne, Judith, Baines, Helen, Rees, Merridie, White, Jenni, Withanage, Aicuratiya, Delcourt, Candice, Carcel, Cheryl, Malavera, Alejandra, Kunchok, Amy, Ray, Elizabeth, Pepper, Elizabeth, Duckett, Emily, Ormond, Sally, Moey, Andrew, Kleinig, Timothy, Maxwell, Vanessa, Baldwin, Chantal, Vallat, Wilson, Field, Deborah, Markus, Romesh, Page, Kirsty, Wheelwright, Danielle, Bolitho, Sam, Faux, Steven, Sangvatanakul, Fix, Brown, Alexis, Walker, Susan, Massey, Jennifer, Hayes, Hillary, Katrak, Pesi, Winker, Annie, Zagami, Alessandro, Bailey, Alanah, Mccormack, Sarah, Murray, Andrew, Rollason, Mark, Taylor, Christopher, O’Rourke, Fintan, Kuang, Ye Min, Burnet, Heike, Liu, Yvonne, Wu, Aileen, Ramirez, Diana, Wijeratne, Tissa, Celestino, Sherisse, Low, Essie, Chen, Cynthia, Bergqvist, Jennifer, Evans, Andrew, Leung, Queenie, Jude, Martin, McQueen, Rachael, Mohr, Katherine, Kernaghan, Latitia, Stockle, Paul, Tan, Boon L., Laubscher, Sara, Schmid, Diana, Spooner, Melissa, Lallu, Bhavesh, Pepperell, Bronwen, Chalissery, John, Mahawish, Karim, DeCaigney, Susan, Broughton, Paula, Knight, Karen, Duque, Veronica, McNaughton, Harry, Lanford, Jeremy, Fu, Vivian, and Wong, Lai-Kin

Abstract

Background and Purpose: The AFFINITY trial (Assessment of Fluoxetine in Stroke Recovery) reported that oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and seizures. After trial medication was ceased at 6 months, survivors were followed to 12 months post-randomization. This preplanned secondary analysis aimed to determine any sustained or delayed effects of fluoxetine at 12 months post-randomization. Methods: AFFINITY was a randomized, parallel-group, double-blind, placebo-controlled trial in adults (n=1280) with a clinical diagnosis of stroke in the previous 2 to 15 days and persisting neurological deficit who were recruited at 43 hospital stroke units in Australia (n=29), New Zealand (4), and Vietnam (10) between 2013 and 2019. Participants were randomized to oral fluoxetine 20 mg once daily (n=642) or matching placebo (n=638) for 6 months and followed until 12 months after randomization. The primary outcome was function, measured by the modified Rankin Scale, at 6 months. Secondary outcomes for these analyses included measures of the modified Rankin Scale, mood, cognition, overall health status, fatigue, health-related quality of life, and safety at 12 months. Results: Adherence to trial medication was for a mean 167 (SD 48) days and similar between randomized groups. At 12 months, the distribution of modified Rankin Scale categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio, 0.93 [95% CI, 0.76–1.14]; P =0.46). Compared with placebo, patients allocated fluoxetine had fewer recurrent ischemic strokes (14 [2.18%] versus 29 [4.55%]; P =0.02), and no longer had significantly more falls (27 [4.21%] versus 15 [2.35%]; P =0.08), bone fractures (23 [3.58%] versus 11 [1.72%]; P =0.05), or seizures (11 [1.71%] versus 8 [1.25%]; P =0.64) at 12 months. Conclusions: Fluoxetine 20 mg daily for 6 months after acute stroke had no delayed or sustained

Published
2021

39. Stroke Unit Care Benefits Patients With Intracerebral Hemorrhage: Systematic Review and Meta-analysis

Author

Langhorne, Peter, Fearon, Patricia, Ronning, Ole M., Kaste, Markku, Palomaki, Heikki, Vemmos, Kostos, Kalra, Lalit, Indredavik, Bent, Blomstrand, Christian, Rodgers, Helen, Dennis, Martin S., Salman, Rustam Al-Shahi, Blomstrand, C., Indredavik, B., Kalra, L., Kaste, M., Palomaki, H., Rodgers, H., Ronning, M.O., Vemmos, K., Asplund, K., Berman, P., Blomstrand, C., Britton, M., Cabral, N.L., Cavallini, A., Dey, P., Hamrin, E., Hankey, G., Indredavik, B., Kalra, L., Kaste, M., Laursen, S.O., Ma, R.H., Patel, N., Rodgers, H., Ronning, M.O., Sivenius, J., Stevens, R., Sulter, G., Svensson, A., Vemmos, K., Wood-Dauphinee, S., and Yagura, H.

Published
2013
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43. Effect of the neutral CLOTS 1 trial on the use of graduated compression stockings in the Efficacy of Nitric Oxide Stroke (ENOS) trial

Author

Ankolekar, Sandeep, Renton, Cheryl, Bereczki, Daniel, Sprigg, Nikola, Payne, Tanya, Gommans, John, Berge, Eivind, Wardlaw, Joanna, Dennis, Martin S, Bath, Philip M W, Amarenco, Pierre, Bath, Philip, Lees, Kennedy R, Muir, Keith, Pocock, Stuart, Shone, Angela, Sinclair, Jane, Venables, Graham, Wardlaw, Joanna, Whynes, David, Bladin, Chris, Caso, Valeria, Chang, Hui Meng, Collins, Ronan, Czlonkowska, Anna, El Etribi, Anwar, Ghani, Abdul Raman, Gommans, John, Phillips, Stephen, Prasad, Kameshwar, de Silva, Asita, Szatmari, Szabolcs, de Tejedor, Exuperio, Wang, Yong-Jun, and Wong, Lawrence

Published
2013
Full Text
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