107 results on '"Denic, S."'
Search Results
2. Type 2 diabetes: The genetic conflict hypothesis
- Author
-
Denic, S., Emerald, S., and Nicholls, M.G.
- Published
- 2013
- Full Text
- View/download PDF
3. On Some Novel Aspects of Consanguineous Marriages
- Author
-
Denic, S., Nagelkerke, N., and Agarwal, M.M.
- Published
- 2011
4. Cancer by negative heterosis: breast and ovarian cancer excess in hybrids of inbred ethnic groups
- Author
-
Denic, S., Khatib, F., Awad, M., Karbani, G., and Milenkovic, J.
- Published
- 2005
- Full Text
- View/download PDF
5. Consanguinity as risk factor for cervical carcinoma
- Author
-
Denic, S
- Published
- 2003
- Full Text
- View/download PDF
6. Longer breast-feeding and protection against childhood leukaemia and lymphomas
- Author
-
Bener, A, Denic, S, and Galadari, S
- Published
- 2001
- Full Text
- View/download PDF
7. Capacity of the Class of MIMO Channels With Incomplete CDI—Properties of Mutual Information for a Class of Channels
- Author
-
Charalambous, Charalambos D., Denic, S. Z., Constantinou, C., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Optimization ,Mathematical optimization ,Kullback–Leibler divergence ,Entropy ,Covariance matrix ,MIMO ,Power allocation ,Library and Information Sciences ,Topology ,Upper and lower bounds ,Multiplexing ,Channel capacity ,Control theory ,Compound channel ,Robustness ,Banks (bodies of water) ,Multiple-input multiple-output (mimo) gaussian channel ,Computer Science::Information Theory ,Mathematics ,Relative entropy constraint ,Mutual information ,Computer Science Applications ,Rayleigh fading ,Probability distributions ,Probability distribution ,Information Systems ,Communication channel - Abstract
This paper is concerned with multiple-input multiple-output (MIMO) wireless channel capacity, when the probability distribution of the channel matrix p(H) is not completely known to the transmitter and the receiver. The partial knowledge of a true probability distribution of the channel matrix p(H) is modelled by a relative entropy D(·∥·) such that D(p∥p nom)≤d, d≥0, where d is the distance from the so-called nominal channel matrix distribution p nom(H). The capacity of this compound channel is equal to the maximin of the mutual information, where the minimum is with respect to the channel matrix distribution, and the maximum is with respect to the covariance matrix of a transmitted signal. The existence of a minimizing probability distribution is proved, and the explicit formula for the minimizing distribution is derived in terms of the nominal distribution p nom(H) and parameter d. A number of properties of the mutual information, minimized over the set of channel distributions, are derived. Specifically, upper and lower bounds are derived for the minimized mutual information, while its convexity with respect to d is shown. In the case of the Rayleigh fading, an explicit formula for the capacity and the optimal transmit covariance matrix are derived. © 2009 IEEE. 55 8 3725 3734
- Published
- 2009
- Full Text
- View/download PDF
8. Information Theoretic Bounds for Compound MIMO Gaussian Channels
- Author
-
Denic, S. Z., Charalambous, Charalambos D., Djouadi, S. M., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Maximin ,Water fillings ,Gaussian ,Matrixes ,Multiplexing ,Matrix (mathematics) ,Control theory ,Frequency domains ,Worst-case channels ,Banks (bodies of water) ,Multipleinput-multiple-output (mimo) gaussian channel ,Mathematics ,Estimation theory ,Pulse shaping circuits ,Bandwidth (signal processing) ,Quadratic gaussian controls ,Channel frequency response ,Computer Science Applications ,Banach spaces ,Mutual informations ,Achievable rates ,Frequency domain ,symbols ,Trellis codes ,H-matrices ,Information Systems ,Information theory ,MIMO ,Gaussian distribution ,Channel estimation ,Library and Information Sciences ,Topology ,Gaussian noise ,Kalman-filtering ,symbols.namesake ,Frequency response ,Power spectral density ,Compound channel ,Computer Science::Information Theory ,Information-theoretic bounds ,Mim devices ,Channel degrading ,Kalman filter ,Normed linear spaces ,Multiple-input multiple-output channels ,Transmitted signals ,Riccati equations - Abstract
In this paper, achievable rates for compound Gaussian multiple-input-multiple-output (MIMO) channels are derived. Two types of channels, modeled in the frequency domain, are considered when: 1) the channel frequency response matrix H belongs to a subset of H∞ normed linear space, and 2) the power spectral density (PSD) matrix of the Gaussian noise belongs to a subset of L1 space. The achievable rates of these two compound channels are related to the maximin of the mutual information rate. The minimum is with respect to the set of all possible H matrices or all possible PSD matrices of the noise. The maximum is with respect to all possible PSD matrices of the transmitted signal with bounded power. For the compound channel modeled by the set of H matrices, it is shown, under certain conditions, that the code for the worst case channel can be used for the whole class of channels. For the same model, the water-filling argument implies that the larger the set of matrices H, the smaller the bandwidth of the transmitted signal will be. For the second compound channel, the explicit relation between the maximizing PSD matrix of the transmitted signal and the minimizing PSD matrix of the noise is found. Two PSD matrices are related through a Riccati equation, which is always present in Kalman filtering and liner-quadratic Gaussian control problems. © 2009 IEEE. 55 4 1603 1617
- Published
- 2009
- Full Text
- View/download PDF
9. Encoder, controller and decoder design of jump linear systems over jump communication channels
- Author
-
Ma, X., Djouadi, S., Charalambous, Charalambos D., Denic, S., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Design ,Controllers ,Vector channels ,Markov processes ,Linear systems ,Data_CODINGANDINFORMATIONTHEORY ,Controller designs ,State information ,Jump linear system ,Channel state information ,Scalar channel ,Vector observations ,Decoder designs ,Rate distortions ,Computer Science::Information Theory - Abstract
In this work, we focus on the encoder, decoder, and controller design for jump linear systems over jump communication channels.The plant state information (PSI) and the channel state information (CSI) are assumed to be known at the both transmitter and the receiver ends. Both the PSI and the CSI are governed by a finite state Markov chain. The control and communication system is designed for the general vector observations over two different channels. One is assumed to be a vector channel, and the other one is a scalar channel. We design the optimal encoder, controller and decoder for both channels and the design scheme achieves the desired distortion. The rate distortions for both cases are also computed. © 2013 AACC American Automatic Control Council. 4239 4244
- Published
- 2013
10. Mutual information expansion for MIMO systems and capacity formulae at low SNR
- Author
-
Ioannou, I., Charalambous, Charalambos D., Denic, S., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Expansion ,Mathematical optimization ,Minimum mean squares ,Waterfilling ,MIMO ,Data_CODINGANDINFORMATIONTHEORY ,Topology ,Upper and lower bounds ,Low snr ,Mutual information expansion ,Channel capacity ,Communication channels (information theory) ,Second orders ,Electrical and Electronic Engineering ,Power constraints ,Mathematics ,Computer Science::Information Theory ,Asymptotic series expansions ,Signal to noise ratio ,Mutual information ,Lower bounds ,Computer Science Applications ,Transmitters ,Mutual informations ,Signal-to-noise ratio (imaging) ,Channel state information ,Modeling and Simulation ,Power allocations ,Low signal-to-noise ratio ,Multiple-input multiple-output channels ,Perfect channel state information ,Asymptotic expansion ,Series expansion ,Mimo systems - Abstract
The paper introduces a new asymptotic series expansion for the mutual information of multiple-input multiple-output (MIMO) channels. The expansion approaches mutual information from below, and for low signal to noise ratio (SNR) first and second order terms give a tight lower bound. The low SNR approximation is used to derive a new water-filling power allocation at the transmitter for the case when the receiver and the transmitter have perfect channel state information. The low SNR approximation is also compared against existing approximations, while the new water-filling policy is related to minimum mean square decoding subject to power constraint. © 2010 IEEE. 15 3 329 331
- Published
- 2011
11. Information theoretic modeling and analysis for global interconnects with process variations
- Author
-
Denic, S. Z., Vasic, B., Charalambous, Charalambos D., Chen, J., Wang, J. M., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Global interconnect ,Engineering ,Design ,Information theory ,Bit-errors ,Semiconductor device modeling ,Data-communication ,Integrated circuit ,Upper and lower bounds ,Semiconductor technology ,law.invention ,law ,Road-maps ,Electronic engineering ,Communication application ,Electrical and Electronic Engineering ,Interconnection ,Achievable rate ,business.industry ,Communication ,Semiconductor device manufacture ,Communication strategy ,Global interconnects ,Parasitic parameter ,Code rate ,Lower bounds ,Communication problems ,Interconnection networks ,Design method ,Reliable communication ,Nano-meter regimes ,Process variation ,Harmful effects ,CMOS ,Code rates ,Hardware and Architecture ,Bit error rate ,Quantum theory ,Modeling and analysis ,Wafer sizes ,Data rates ,Bit error rate process variations ,business ,Quantum chemistry ,Software ,Interconnect design - Abstract
As the CMOS semiconductor technology enters nanometer regime, interconnect processes must be compatible with device roadmaps and meet manufacturing targets at the specified wafer size. The resulting ubiquitous process variations cause errors in data delivering through interconnects. This paper proposes an Information Theory based design method to accommodate process variations. Different from the traditional delay based design metric, the current approach uses achievable rate to relate interconnect designs directly to communication applications. More specifically, the data communication over a typical interconnect, a bus, subject to process variations (uncertain bus), is defined as a communication problem under uncertainty. A data rate, called the achievable rate, is computed for such a bus, which represents the lower bound on the maximal data rate attainable over the bus. When a data rate applied over the bus is smaller than the achievable data rate, a reliable communication can be guaranteed regardless of process variations, i.e., a bit error rate arbitrarily close to zero is achievable. A single communication strategy to combat the process variations is proposed whose code rate is equal to the computed achievable rate. The simulations show that the variations in the interconnect resistivity could have the most harmful effect regarding the achievable rate reduction. Also, the simulations illustrate the importance of taking into account bus parasitic parameters correlations when measuring the influence of the process variations on the achievable rates. © 2006 IEEE. 19 3 397 410
- Published
- 2011
12. Capacity for MIMO systems at low SNR
- Author
-
Ioannou, I., Charalambous, Charalambos D., Denic, S., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Signal processing ,Minimum mean squares ,MIMO ,Data_CODINGANDINFORMATIONTHEORY ,Topology ,Upper and lower bounds ,Low snr ,Channel capacity ,Control theory ,Power constraints ,Computer Science::Information Theory ,Mathematics ,Asymptotic series expansions ,Signal to noise ratio ,Transmitter ,Mutual information ,Transmitters ,Mutual informations ,Water filling ,Signal-to-noise ratio (imaging) ,Channel state information ,Power allocations ,Low signal-to-noise ratio ,Multiple-input multiple-output channels ,Perfect channel state information ,Mimo systems ,Outage probability ,Upper bound ,Decoding methods - Abstract
The paper introduces an asymptotic series expansion for the mutual information of Multiple-Input Multiple-Output (MIMO) channels. For low signal to noise ratio (SNR) the first term of expansion approaches mutual information from below. Using the low SNR approximation a new water filling power allocation at the transmitter is derived when the receiver and the transmitter have perfect channel state information (CSITR). The low SNR approximation is related to existing approximation while the new water filling policy is related to minimum mean square decoding subject to power constraint. Finally, an upper bound for the outage probability at low SNR is presented. ©2010 IEEE.
- Published
- 2010
- Full Text
- View/download PDF
13. Robust control of uncertain context-sensitive probabilistic Boolean networks
- Author
-
Denic, S. Z., Vasic, B., Charalambous, Charalambos D., Palanivelu, R., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Kullback–Leibler divergence ,Probabilistic boolean networks ,Relative entropy ,Proteome ,Entropy ,Gene regulatory network ,Probabilistic boolean network ,Robust control ,Signal transduction ,Control signal ,Complex structure ,Gene regulatory networks ,Mathematical model ,Mean square ,Attractor ,Risks ,Models, biological ,Mathematics ,Gene expression regulation ,Engineering exhibitions ,Mathematical models ,Energy ,Malignant melanoma ,Controllers ,Uncertainty ,Complex network ,Computer simulation ,Relative stabilities ,Modeling and Simulation ,Uncertainty analysis ,Robustness (control systems) ,In-control ,Signal Transduction ,Biotechnology ,Mathematical optimization ,Context-sensitive ,Models, Biological ,Article ,Undesirable state ,Measurement errors ,Measurement error ,Control theory ,Genetics ,Entropy (information theory) ,Computer Simulation ,Free energy ,Molecular Biology ,Measurement device ,Probability ,Probabilistic logic ,Cell Biology ,Logistic models ,Costs ,Cell membranes ,Logistic Models ,Boolean network ,Gene Expression Regulation ,Controlled study ,Risk sensitive control - Abstract
Uncertainty is an intrinsic phenomenon in control of gene regulatory networks (GRNs). The presence of uncertainty is related to impreciseness of GRN models due to: (1) Errors caused by imperfection of measurement devices and (2) Models' inability to fully capture a complex structure of the GRN. Consequently, there is a discrepancy between actual behaviour of the GRN and what is predicted by its mathematical model. This can result in false control signals, which can drive a cell to an undesirable state. To address the problem of control under uncertainties, a risk-sensitive control paradigm is proposed. Robustness is accomplished by minimisation of the mean exponential cost as opposed to, for instance, minimisation of the mean square cost by risk-neutral controllers. The authors derive an optimal risk-sensitive controller when a GRN is modelled by a context-sensitive probabilistic Boolean network (CSPBN). By using a relation between the relative entropy and free-energy, a relative stability of the cost achieved by the risk-sensitive controller is demonstrated when the distribution of the CSPBN attractors is perturbed, as opposed to the cost of the risk-neutral controller that exhibits increase. The use of the relation between the relative entropy and free-energy to analyse the influence of a particular attractor on the robustness of the controller is studied. The efficiency of the risk-sensitive controller is tested for the CSPBN obtained from the study of malignant melanoma. © The Institution of Engineering and Technology. 3 4 279 295
- Published
- 2009
14. Control of continuous-time linear Gaussian systems over additive Gaussian wireless fading channels: A separation principle
- Author
-
Charalambous, Charalambos D., Farhadi, A., Denic, S. Z., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Stabilizability and observability ,Observability ,Asymptotic stability ,Gaussian ,Fading channels ,White noise ,Separation principle ,symbols.namesake ,Channel capacity ,Control theory ,Electrical and Electronic Engineering ,Gaussian process ,Mathematics ,Computer Science::Information Theory ,Gaussian wireless fading channels ,Linear system ,Invariance ,Continuous time systems ,Linear control systems ,Computer Science Applications ,Networked control system ,Mutual information ,Additive white Gaussian noise ,Continuous time ,Control and Systems Engineering ,symbols ,Additive noise - Abstract
This note is concerned with the control of continuous-time linear Gaussian systems over additive white noise wireless fading channels subject to capacity constraints. Necessary and sufficient conditions are derived, for bounded asymptotic and asymptotic observability and stabilizability in the mean square sense, for controlling such systems. For the case of a noiseless time-invariant system controlled over a continuous-time additive white Gaussian noise channel, the sufficient condition for stabilizability and observability states that the capacity of the channel C must satisfy C > Sigma{i;Re(lambdai(A))ges0} Re(lambdai(A)), where A is the system matrix and lambdai(A) denotes the eigenvalues of A. The necessary condition states that the channel capacity must satisfy C ges Sigma {i;Re(lambdai(A))ges0} Re(lambdai(A)). Further, it is shown that a separation principle holds between the design of the communication and the control subsystems, implying that the controller that would be optimal in the absence of the communication channel is also optimal for the problem of controlling the system over the communication channel.
- Published
- 2008
15. Control Over Wireless Communication Channel for Continuous-Time Systems
- Author
-
Charalambous, Charalambos D., Denic, S. Z., Farhadi, A., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Observability ,Gaussian ,Time invariant systems ,Channel capacity ,White noise ,Fading (radio) ,Separation principle ,Optimal control ,Communication channels (information theory) ,Continuous-time systems ,symbols.namesake ,Control theory ,Gaussian channels ,symbols ,Wireless telecommunication systems ,System coefficient ,Computer Science::Information Theory ,Communication channel ,Mathematics - Abstract
This paper is concerned with the control of one dimensional continuous time linear Gaussian systems over additive white noise wireless fading channels subject to capacity constraints. Necessary and sufficient conditions are derived, for bounded asymptotic and asymptotic observability and stabillzability in the mean square sense, for controlling such systems. For the case of a noiseless time-invariant system controlled over a continuous time additive white Gaussian channel, the sufficient condition for stabilizability and observability states that the capacity of the channel, Ca, satisfies, Ca > [A]+, where A is the system coefficient and a]+ = a, if a ≥ 0 and [a+ = 0, if a < 0. Moreover, the necessary condition states that the channel capacity must satisfy C a ≥ |A|+. It is shown that a separation principle holds between the design of the communication and the control sub-systems, implying that the controller that would be optimal in the absence of the communication channel is also optimal for the problem of the controlling the system over the communication channel. © 2005 IEEE. 2005 3225 3230
- Published
- 2006
- Full Text
- View/download PDF
16. Control of discrete-time partially-observed jump linear systems over causal communication systems
- Author
-
Denic, S. Z., Charalambous, Charalambos D., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Data processing ,Problem solving ,Communication channels (information theory) ,Probability distributions ,System stability ,Markov processes ,Self-mutual information ,Discrete time control systems ,Linear systems ,Causal channels - Abstract
We consider the problem of control of discrete-time partially-observed jump linear system over a noisy causal communication channel. Necessary conditions for observability and stabilizability in probability and r-th mean of a jump linear system driven by a Markov chain are derived. The methodology is information theoretic and it is based on an alternative definition of mutual information between two random processes which is restricted to a causal channel. Specifically, the self-mutual information is restricted to Radon-Nykodym Derivatives corresponding to causal channels. This gives rise to information capacity and rate distortion formulaes which involve causal operations, leading to a new set of data processing inequalities. © 2006 IEEE. 496 501
- Published
- 2006
17. Stochastic power control for wireless networks via SDEs: Probabilistic QoS measures
- Author
-
Charalambous, Charalambos D., Djouadi, S. M., Denic, S. Z., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Optimization ,Differential equations ,Mathematical optimization ,Telecommunication links ,Library and Information Sciences ,Mobile communication ,Multipath channels ,Stochastic differential equation ,Communication channels (information theory) ,Quality of service ,Control theory ,Linear programming ,Chernoff bound ,Wireless telecommunication systems ,Mathematics ,Probability ,Stochastic control ,Stochastic process ,Probabilistic logic ,Random processes ,Multipath propagation ,Optimal control ,Computer Science Applications ,Power control ,Stochastic optimal control ,Mobile telecommunication systems ,State space methods ,Convex optimization ,Stochastic differential equations ,Information Systems - Abstract
The power control of wireless networks is formulated using a stochastic optimal control framework, in which the evolution of the channel is described by stochastic differential equations (SDEs). The latter rapture the spatio-temporal variations of the communication link, as well as the randomness. This class of models is more realistic than the static models usually encountered in the literature. Under this scenario, average and probabilistic Quality of Service (QoS) measures are introduced to evaluate the performance of any control strategy by using Chernoff bounds. Moreover, the Chernoff bound is computed explicitly, while the solution of the stochastic optimal power control is obtained through pathwise optimization. The pathwise optimization can be solved using linear programming if predictable control strategies are introduced. Finally, if predictable control strategies do not hold, it is shown that the proposed power control problem reduces to particular convex optimizations. © 2005 IEEE. 51 12 4396 4401
- Published
- 2005
18. Robust capacity of a Gaussian noise channel with channel and noise uncertainty
- Author
-
Charalambous, Charalambos D., Denic, S. Z., Djouadi, S. M., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Signal processing ,Problem solving ,Communication channels (information theory) ,Robust capacity ,Spectral density ,Frequency response ,Gaussian noise channels ,Channel capacity ,Gaussian noise (electronic) ,Transmitted signals ,Robustness (control systems) ,Computer Science::Information Theory - Abstract
This paper is concerned with the problem of defining, and computing the capacity of a continuous-time additive Gaussian noise communication channel when the true frequency response of the channel, and the power spectral density of the noise are not perfectly known, and the transmitted signal is a wide-sense stationary process constrained in power. The uncertainties of a true channel frequency response and power spectral density of the noise are described by weighted balls in the H ∞ space. In that way two sets are defined that describe the set of all possible channel frequency responses, and the set of all possible power spectral densities of the noise. The ball radii depend on the degree of uncertainty that one has about the true channel frequency response, and power spectral density of the noise. The channel capacity is defined as the max-min-min of a mutual information rate between transmitted, and received signals, where the first minimum is taken over the set of all possible noises, the second minimum is taken over the set of all possible channel frequency responses, and maximum is over the set of all possible power spectral densities of transmitted signal with constrained power. It is shown that such defined channel capacity, called robust capacity, is equal to the operational capacity that represents the theoretical maximum of all attainable rates over a given channel. ©2005 AACC. 3 1829 1834
- Published
- 2005
19. Robust capacity for additive colored Gaussian uncertain channels
- Author
-
Charalambous, Charalambos D., Denic, S. Z., Djouadi, S. M., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Robust capacity ,Waterfilling ,Transmitted signal ,Noise power spectral density ,Input signal ,Operational capacity ,Normed linear space ,Automation ,Spectral density ,Control theory ,Power spectral density ,Control ,Additive gaussian channel ,Computer Science::Information Theory ,Communication channels ,Second-order systemss ,Robust transmission ,Channel transfer functions ,Uncertainty ,Channel capacity ,Transmitter power ,Banach spaces ,Mutual informations ,Continuous time ,Gaussians ,Channel uncertainties ,Uncertainty models ,Telecommunication ,Wide-sense stationaries - Abstract
This paper is concerned with the definition and computation of channel capacity of continuous time additive Gaussian channels, when the channel is subject to uncertainty, the noise power spectral density is known and the input signal is wide-sense stationary and constrained in power. The uncertainty description of the channel transfer function is described by the set of all channels which belong to a ball in a normed linear space, known as H ∞ space. Two uncertainty models are used that are borrowed from the control theory, additive, and multiplicative. The channel capacity, that we call robust capacity, is then defined as a maxi-min of mutual information rate in which the minimization is over the uncertainty set while the maximization is over all transmitted signals having finite power. An exact formulae for the robust capacity is derived. Part of the results include a modified version of the water-filling equation, describing how the optimal transmitter power depends on the channel uncertainty. The conditions are introduced under which the robust capacity is equivalent to operational capacity. Finally, an example is worked out to show the effect of uncertainty in case of the second order system. Copyright © 2005 IFAC. 16 111 116
- Published
- 2005
20. Robust capacity of white Gaussian noise channels with uncertainty
- Author
-
Charalambous, Charalambos D., Denic, S. Z., Djouadi, S. M., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Mathematical models ,Robust capacity ,White acoustic noise ,Signal receivers ,Signal encoding ,Channel capacity ,Communication systems ,Additive white gaussian noise (awgn) ,Spurious signal noise ,Transmitters ,Communication channels (information theory) ,Frequency response ,Control theory ,Transfer functions ,Uncertainty models ,Coding theory ,Jamming ,Robustness (control systems) ,Integral equations ,Computer Science::Information Theory - Abstract
This paper concerns the problem of defining, and computing the channel capacity of a continuous time additive white Gaussian noise channel when the true frequency response of the channel is not completely known to the transmitter, and receiver, and when a transmitted signal is a wide sense stationary process constrained in power. To represent the uncertainty of a true frequency response two basic uncertainty models are used that are borrowed from the control theory, additive, and multiplicative. Here, the true frequency response although unknown, belongs to a ball in a normed linear space. The radius of the ball is a function of frequency, and it depends on the size of the uncertainty. The channel capacity, called robust capacity is defined as a max-min of the mutual information rate, where the maximum is over all power spectral densities of the input signal with constrained power, and minimum is over the uncertainty set of frequency response. The robust capacity formula is explicitly computed describing how the channel uncertainty reduces the capacity. The water-filling formula is derived showing how the optimal transmitted power changes with uncertainty. At the end, it is shown that a channel coding theorem, and its converse under certain conditions imposed on the uncertainty set hold for the robust maximin capacity. 5 4880 4884
- Published
- 2004
21. Capacity of gaussian channels with noise uncertainty
- Author
-
Denic, S. Z., Charalambous, Charalambos D., Djouadi, S. M., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Communication channels ,Problem solving ,Uncertain noise ,Spectral density ,Signal interference ,Uncertain systems ,Channel capacity ,Doppler effect ,Communication systems ,Spectrum analysis ,Computer Science::Information Theory ,Spurious signal noise ,Continous time channels - Abstract
In this paper the problem of defining, and computing the capacity of a communication channel when the statistic of an additive noise is not fully known, is addressed. The communication channel is specified as a continuous time channel with the known transfer function, where the transmitted signal is constrained in power, and an additive Gaussian noise channel is assumed. The power spectral density of the noise although unknown belongs to a known set defined through the uncertainty of the filter the shapes the power spectral density of the noise. The channel capacity is defined as the max-min of mutual information rate between the transmitted, and received signals, where the infimum is taken over the set of all possible power spectral densities of the noise, and supremum is taken over all power spectral densities of transmitted signal with constrained power. It is shown that the so defined channel capacity is equal to the operational capacity that represents the supremum of all attainable rates over a given channel. 1 421 424
- Published
- 2004
22. On the channel capacity of wireless fading channels
- Author
-
Charalambous, Charalambos D., Denic, S., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Decoding ,Signal receivers ,Random processes ,Data_CODINGANDINFORMATIONTHEORY ,Signal encoding ,Channel capacity ,Feedback ,Transmitters ,Communication channels (information theory) ,Decoding error ,Optimal encoding function ,Flat fading time varying wireless channels ,Encoding ,Wireless telecommunication systems ,Flat fading time varying wireless channel ,Computer Science::Information Theory - Abstract
The objectives of this paper are twofold. First, to point out the significance of certain results on stochastic processes in computing the channel capacity for flat fading wireless channels. Second, to design an optimal encoding and decoding strategies for general sources, when the channel is perfectly known to both transmitter and receiver. We give an optimal encoding and decoding scheme with noiseless feedback achieving the channel capacity and consider the effect of feedback on decoding error. It turns out that the optimal encoding function has two parts; one part behaves as power control and the other part represents the decoding error. 4 4036 4041
- Published
- 2002
23. Stochastic power control for short-term flat fading wireless networks: Almost sure QoS measures
- Author
-
Charalambous, Charalambos D., Denic, S. Z., Djouadi, S. M., Menemenlis, N., and Charalambous, Charalambos D. [0000-0002-2168-0231]
- Subjects
Stochastic control ,Optimization ,Differential equations ,Mathematical optimization ,Optimization problem ,Wireless network ,Probabilistic-based design optimization ,Stochastic power control ,Telecommunication networks ,Optimal control systems ,Fading (radio) ,Optimal control ,Stochastic programming ,Power control ,Communication channels (information theory) ,Stochastic control systems ,Quality of service ,Control theory ,Linear programming ,Wireless telecommunication systems ,Stochastic optimization ,Mathematics ,Probability - Abstract
The power control of wireless networks is formulated using a stochastic optimal control framework, in which the evolution of the channel is described by stochastic differential equations. Under this scenario, average and probabilistic Quality of Service (QoS) measures are introduced to evaluate the performance of any control strategy, while a solution of the stochastic optimal power control is obtained through pathwise optimization. The pathwise optimization can be solved using linear programming techniques. Several optimization problems are identified. 2 Journal Article 1049 1052
- Published
- 2001
24. On Some Novel Aspects of Consanguineous Marriages
- Author
-
Denic, S., primary, Nagelkerke, N., additional, and Agarwal, M.M., additional
- Published
- 2010
- Full Text
- View/download PDF
25. Quality of age data in patients from developing countries
- Author
-
Denic, S., primary, Saadi, H., additional, and Khatib, F., additional
- Published
- 2004
- Full Text
- View/download PDF
26. Linear Minimum Mean-Squared Error Channel Estimation for Per-Subcarrier Antenna Selection.
- Author
-
Vithanage, C. and Denic, S.
- Published
- 2010
- Full Text
- View/download PDF
27. 94. How relative risk of cancer from consanguinity and consanguinity rate affect number of cancer cases in United Arab Emirates
- Author
-
Denic, S., primary, Khatib, F., additional, Awad, M., additional, and Milenkovic, J., additional
- Published
- 2003
- Full Text
- View/download PDF
28. LDPC-Coded MIMO Optical Communication Over the Atmospheric Turbulence Channel.
- Author
-
Djordjevic, I.B., Denic, S., Anguita, J., Vasic, B., and Neifeld, M.A.
- Published
- 2007
- Full Text
- View/download PDF
29. Robust Control Over Uncertain Communication Channels.
- Author
-
Charalambous, C.D., Farhadi, A., Denic, S., and Rezaei, F.
- Published
- 2005
- Full Text
- View/download PDF
30. Consanguinity decreases risk of breast cancer – cervical cancer unaffected
- Author
-
Denic, S, primary and Bener, A, additional
- Published
- 2001
- Full Text
- View/download PDF
31. Screening for cervical cancer among Arab women
- Author
-
Bener, A, primary, Denic, S, additional, and Alwash, R, additional
- Published
- 2001
- Full Text
- View/download PDF
32. Frequency and management of germ-cell tumors in a third-world country.
- Author
-
Denic, S, primary
- Published
- 1998
- Full Text
- View/download PDF
33. Observations supporting the existence of true local metastases of cancer
- Author
-
Denic, S., primary
- Published
- 1994
- Full Text
- View/download PDF
34. LDPC-Coded MIMO Optical Communication Over the Atmospheric Turbulence Channel.
- Author
-
Djordjevic, I.B., Denic, S., Anguita, J., Vasic, B., and Neifeld, M.A.
- Abstract
In this paper, coded multiple-input-multiple-output (MIMO) communication schemes for data transmission over the optical atmospheric turbulence channels are studied. Two strategies are proposed and compared. The first is based on repetition coding, and the second on space-time (ST) coding. Both approaches employ low-density parity-check (LDPC) codes. The LDPC codes are designed using the concept of pairwise balanced design (PBD), balanced incomplete block design (BIBBD), and block-circulant (array) codes. To improve the spectral efficiency, we employ a bit-interleaved (BI) LDPC-coded modulation based on the pulse amplitude modulation (PAM). A better bit error rate (BER) performance is achieved by the iteration of extrinsic information between a demapper and LDPC decoder. The simulations show that the LDPC-coded MIMO schemes can operate under a strong atmospheric turbulence and at the same time provide excellent coding gains compared with the transmission of uncoded data. To verify the efficiency of the proposed coding schemes, achievable information rates are computed when the turbulence is modeled by a gamma-gamma distribution. [ABSTRACT FROM PUBLISHER]
- Published
- 2008
- Full Text
- View/download PDF
35. Consanguinity and family history of cancer in children with leukemia and lymphomas.
- Author
-
Bener, Abdulbari, Denic, Srdjan, Al-Mazrouei, Mariam, Bener, A, Denic, S, and Al-Mazrouei, M
- Published
- 2001
- Full Text
- View/download PDF
36. On the channel capacity of wireless fading channels.
- Author
-
Charalambous, C.D. and Denic, S.
- Published
- 2002
- Full Text
- View/download PDF
37. HTLV-I infection in Iraq.
- Author
-
Denic, S, Nolan, P, Doherty, J, Garson, J, Tuke, P, and Tedder, R
- Subjects
- *
ENZYME-linked immunosorbent assay , *FAMILY health , *LYMPHOMAS , *RNA virus infections , *DISEASE complications - Published
- 1990
- Full Text
- View/download PDF
38. Altruism as an Explanation for Human Consanguinity.
- Author
-
Denic S and Agarwal MM
- Abstract
Background: Human inbreeding is a sociobiological puzzle. Despite widespread knowledge of its potential for genetic disorders, human consanguinity remains surprisingly common. The current reasons explaining its continued persistence in today's modern world have major shortcomings., Summary: We propose that the Neolithic Agrarian revolution modified the structure of populations. It increased competition for the limited resources in which a larger group had better chances of survival. As a result, small, drifting, socially open bands of hunter-gatherers were transformed into bigger, less mobile, and more powerful kinship groups (tribes). In this transformation, a central role was played by human trust - an aspect of human altruism which is a universal sociobiological principle of behavior. Altruism (and trust) is an essential premise of social contracts such as economic cooperation, marriage arrangement, and creation of alliances between people. In kinship groups, human trust is limited to kin, so tribes remain small, economically poor, and consanguineous due to lack of nonkin mates. The expanding of trust from kin to that of nonbiological relatives increases the size of human groups, fosters economic wealth, and decreases the rate of consanguinity. Key Messages: The lack of nonkin altruism leads to: (a) poverty (due to poor economic cooperation with nonkin), (b) maintaining small group size, and (c) inbreeding., (© 2021 The Author(s) Published by S. Karger AG, Basel.)
- Published
- 2021
- Full Text
- View/download PDF
39. Consensus Statement by an Expert Panel on the Diagnosis and Management of Iron Deficiency Anemia in the Gulf Cooperation Council Countries.
- Author
-
Aleem A, Alsayegh F, Keshav S, Alfadda A, Alfadhli AA, Al-Jebreen A, Al-Kasim F, Almuhaini A, Al-Zahrani H, Batwa F, Denic S, Jazzar A, Owaidah T, Qari M, Qari Y, and Taha M
- Subjects
- Adult, Child, Preschool, Consensus, Diagnosis, Differential, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Middle East, Pregnancy, Risk Factors, Young Adult, Anemia, Iron-Deficiency diagnosis, Anemia, Iron-Deficiency etiology, Anemia, Iron-Deficiency therapy, Practice Guidelines as Topic
- Abstract
Background: Iron deficiency (ID) and ID anemia (IDA) are common in the member states of the Gulf Cooperation Council (GCC). The unique genetic and lifestyle factors of the patient population in the region have necessitated the development of recommendations to help educate health-care professionals on appropriate diagnosis and management of ID/IDA., Methods: A panel of regional experts, including gastroenterologists and hematologists with expertise in the treatment of IDA, was convened to develop regional practice recommendations for ID/IDA. After reviewing the regional and international literature, the expert panel developed consensus recommendations for screening, diagnosis, and treatment of patients with IDA in the GCC region., Results: The recommendations proposed were customized to the patient population keeping in view the increasingly recognized burden of coeliac disease, high fertility and obesity rates, high prevalence of alpha- and beta-thalassemia traits, and poor tolerance and low treatment compliance with oral iron therapy., Conclusions: This consensus statement proposes recommendations for screening, diagnosis, and treatment of IDA in the GCC region., (© 2019 The Author(s) Published by S. Karger AG, Basel.)
- Published
- 2020
- Full Text
- View/download PDF
40. Breast cancer protection by genomic imprinting in close kin families.
- Author
-
Denic S and Agarwal MM
- Subjects
- Female, Humans, Infant, Newborn, Breast Neoplasms genetics, Breast Neoplasms prevention & control, Fetal Development, Genomic Imprinting, Models, Genetic
- Abstract
Human inbreeding generally reduces breast cancer risk (BCR). When the parents are biologically related, their infants have a lower birth weight due to smaller body organs. The undersized breasts, because of fewer mammary stem cells, have a lower likelihood of malignant conversion. Fetal growth is regulated by genomically imprinted genes which are in conflict; they promote growth when derived from the father and suppress growth when derived from the mother. The kinship theory explicates that the intensity of conflict between these genes affects growth and therefore the size of the newborn. In descendants of closely related parents, this gene clash is less resulting in a smaller infant. In this review, we elucidate the different mechanisms by which human inbreeding affects BCR, and why this risk is dissimilar in different inbred populations.
- Published
- 2017
- Full Text
- View/download PDF
41. KIN AND NON-KIN MARRIAGES AND FAMILY STRUCTURE IN A RICH TRIBAL SOCIETY.
- Author
-
Bakoush O, Bredan A, and Denic S
- Subjects
- Adult, Family, Family Characteristics, Female, Humans, Male, Middle Aged, Parents psychology, United Arab Emirates, Consanguinity, Marriage statistics & numerical data, Population Groups, Socioeconomic Factors
- Abstract
Human consanguinity is often attributed to poverty, lack of education and social insecurity. Nevertheless, kin unions continue to be arranged in socioeconomically transformed societies. This study examined the structure of families and marriages in the rich tribal society of the United Arab Emirates, which has had a high gross domestic product for the last two generations and currently has one of the highest in the world. The respondents were 217 national medical students whose families are proportionally distributed to the population of the country emirates. The rate of parental consanguinity (defined as a union of any two cousins) was 36%. The social status and mean size of consanguineous and non-consanguineous families were not significantly different. In non-consanguineous families, polygamy was more common and the number of half-siblings per family was higher. The extended families were on average 7% larger among non-consanguineous families. In contrast, for the extended families of the participants' grandparents, non-consanguineous families were smaller than their consanguineous counterparts. Participants from consanguineous families indicated that marriage of either a son or daughter was more difficult to arrange than did participants from non-consanguineous families. Though consanguineous parents had their offspring marry consanguineously more often than non-consanguineous parents, the numbers of married offspring in the two groups of families were not different. Consanguineous parents have more difficulty than non-consanguineous parents in finding spouses for themselves and for their offspring, and they arranged kin marriages for their children more often.
- Published
- 2016
- Full Text
- View/download PDF
42. Correction: Penetration of the Stigma and Style Elicits a Novel Transcriptome in Pollen Tubes, Pointing to Genes Critical for Growth in a Pistil.
- Author
-
Qin Y, Leydon AR, Manziello A, Pandey R, Mount D, Denic S, Vasic B, Johnson MA, and Palanivelu R
- Abstract
[This corrects the article DOI: 10.1371/journal.pgen.1000621.].
- Published
- 2016
- Full Text
- View/download PDF
43. Prevalence of neutropenia in children by nationality.
- Author
-
Denic S, Narchi H, Al Mekaini LA, Al-Hammadi S, Al Jabri ON, and Souid AK
- Abstract
Background: A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo unnecessary investigations. This study aims to ascertain the prevalence of neutropenia (NP) in a large cohort of children from North African, Middle Eastern, and Asian countries residing in the United Arab Emirates., Methods: Neutrophil counts of 26,542 children (one day to six years of age) from 86 countries were analyzed. The subjects were enrolled in the Well-Child-Care program of Ambulatory Health Services of Emirate of Abu Dhabi, United Arab Emirates. NP was defined as a neutrophil count <1.5 × 10(9)/L and severe NP <0.5 × 10(9)/L., Results: The neutrophil counts reached a nadir in the fourth week of life and changed slightly from the age of six-months to six-years. The frequency of NP was (from West-to-East): North African Arabs 15.4 %, Green Crescent Arabs 9.8 %, Peninsular Arabs 10.9 %, Iranians 3.1 %, Afghanis 2.5 %, Pakistanis 5.6 %, Indians 10.2 %, and Filipinos 7.3 %. The frequency of severe NP in North African Arabs (Sudanese) was 2.8 %, Green Crescent and Peninsular Arabs ≤1 %, Indians 1.5 %, and Filipinos 1.8 %. In 12,703 Emirati children, the frequency of NP was 10.6 % similar to their adult counterparts., Conclusion: The prevalence of childhood NP varied considerably by geoethnicity. Measures to prevent the inappropriate investigations of healthy children with benign neutropenia are proposed.
- Published
- 2016
- Full Text
- View/download PDF
44. Red cell parameters in infant and children from the Arabian Peninsula.
- Author
-
Mekaini LA, Denic S, Jabri ON, Narchi H, Souid AK, and Al-Hammadi S
- Abstract
α+-Thalassemia trait and iron deficiency anemia are frequent causes of microcytosis and a common diagnostic challenge in Arabian children. In this study, their prevalences and effects on the red cell parameters were evaluated in 28,457 children aged one day to 6 years. α+-Thalassemia trait was considered to be present when mean cell volume (MCV) was <94 fL at birth and iron deficiency anemia when red cell distribution width (RDW) was >14.5%. The prevalence of α+-thalassemia trait was 15.7% (502/3,191), which was similar to previously reported values for adults (9-14%). Iron deficiency anemia peaked at 7 months (53%) and then declined at a rate of 8% per year. The nadirs of red blood cell count (RBC) and hemoglobin concentration (Hb) occurred at two months of age (physiological anemia). Subsequently, Hb increased at a rate similar to that of MCV, demonstrating the two processes are coupled. The third percentile MCV in children older than 3 months was ≤64 fL, which was significantly lower than that in European children. The third percentile Hb, on the other hand, was similar to that in European children. Thus, α+-thalassemia trait and iron deficiency anemia are exceptionally frequent in Arabian children and their red cell indices are considerably different from European-based norms. Careful interpretation of red cell parameters is required for the evaluation of microcytic anemia in Arabian children.
- Published
- 2015
45. Half of the Emirati population has abnormal red cell parameters: challenges for standards and screening guidelines.
- Author
-
Al-Dabbagh B, Shawqi S, Yasin J, Al Essa A, Nagelkerke N, and Denic S
- Subjects
- Adolescent, Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Practice Guidelines as Topic standards, Reference Standards, United Arab Emirates, Young Adult, Erythrocyte Indices, Hemoglobinopathies blood, Hemoglobinopathies diagnosis
- Abstract
In populations with high prevalences of iron deficiency and thalassemia trait, many apparently healthy individuals have abnormal erythroid parameters, which may cause diagnostic problems in clinical practice. We studied the prevalence and causes of red cell parameter values outside their reference ranges in 394 healthy individuals of Bedouin Arab origin, who had complete blood counts (CBCs), hemoglobin (Hb) analyses and serum ferritin tests done. Their mean age ± standard deviation (SD) was 24.8 ± 4.9 years and 51.8% were females. Overall, 53.0% (209/394) had low Hb, MCV or MCH or high RDW. Anemia was present in 27.0% (55/204) of the women and 3.0% (6/190) of the men. Overall prevalence of MCV < 80.0 fL was 45.0% (176/394) and MCH < 27.0 pg was 48.0% (190/394); RDW > 14.0% was found in 21.0% (43/204) of women and 7.0% (14/190) of men. Of the women, 16.0% had iron deficiency anemia (33/204) and 65.0% had ferritin values of < 30.0 μg/L (133/204). The estimated prevalence of α-thalassemia (α-thal) trait in men was 32.0% (60/190) and that of β-thalassemia (β-thal) trait in both sexes was 3.0% (12/394). In conclusion, half of the healthy Emirati population have abnormal CBC values. For clinical purposes, they require reference standards for red cells that are derived from their own population. Screening of women for iron deficiency is justified due to a high prevalence of iron deficiency.
- Published
- 2014
- Full Text
- View/download PDF
46. β-Thalassemia in Abu Dhabi: consanguinity and tribal stratification are major factors explaining the high prevalence of the disease.
- Author
-
Denic S, Aden B, Nagelkerke N, and Essa AA
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Consanguinity, Female, Gene Frequency, Genotype, Heterozygote, Humans, Male, Middle Aged, Mutation, Prevalence, United Arab Emirates epidemiology, Young Adult, beta-Thalassemia epidemiology, beta-Thalassemia genetics
- Abstract
Tribalism and consanguineous marriages are common in parts of the world with a high prevalence of the β-thalassemia (β-thal) mutations, and increase the risks of homozygosity for this and other recessive disorders. We explored the frequency of β-thal genes and β-thal carriers in 5672 subjects screened before marriage, of whom 2262 were couples. The mean coefficient of inbreeding (F) in the population was estimated from self-reported relationships to prospective spouses in 383 subjects. Overall frequency of β-thal mutations and β-thal carriers in the population were 1.16 and 2.3%, respectively. Among the 14 largest tribes, β-thal carrier frequencies varied from 0 to 13.6%. The estimated F in the population was 0.022. The expected number of couples needed to be screened to detect one couple who were both β-thal carriers in the non inbreeding (F = 0) and inbreeding (F = 0.022) population was 1858 and 646, respectively. However, among 2262 couples, 10 were both β-thal carriers, i.e., 1 in 226 couples, significantly (p = 0.02) more than expected by taking only inbreeding into account. Although β-thal mutations are relatively rare, the burden of β-thal disease is increased eight-fold by tribalism and consanguinity.
- Published
- 2013
- Full Text
- View/download PDF
47. Hemoglobin A2 Lowered by Iron Deficiency and α -Thalassemia: Should Screening Recommendation for β -Thalassemia Change?
- Author
-
Denic S, Agarwal MM, Al Dabbagh B, El Essa A, Takala M, Showqi S, and Yassin J
- Abstract
Screening for β -thalassemia trait (BTT) relies on measuring hemoglobin (Hb) A2. Since multiple factors can affect HbA2 levels, the screening can become unreliable. In 1356 healthy Arabs enrolled into a federally funded premarital BTT screening program, the effects of iron deficiency (ID), α (+)-thalassemia trait, gender, smoking, and tribalism on HbA2 were studied. The complete blood count and hemoglobin fractions were determined on the entire cohort; serum ferritin (<15 μ g/L) in 391 subjects was used to determine ID. BTT was present in 29 (2.1%) subjects (HbA2 > 3.5%). Among 77(20.3%) subjects with ID, the mean HbA2 (2.30 ± 0.23%) was 0.2% lower than in subjects without iron deficiency (2.50 ± 0.24%, P < 0.0001). In 65 (38%)/172 subjects with phenotypic α (+)-thalassemia trait, the mean HbA2 (2.43 ± 0.24%) was 0.13% lower than in subjects without α (+)-thalassemia trait, P < 0.0001. The mean HbA2 did not differ between males and females, smokers and nonsmokers, and between the tribes. Thus, 35 (2.6%) subjects with HbA2 between 3.2 and 3.5% were at a risk of false negative diagnosis of BTT. Since iron deficiency and α (+)-thalassemia are both common and both lower HbA2, modifications in screening recommendations for BTT are proposed.
- Published
- 2013
- Full Text
- View/download PDF
48. A call for screening for benign neutropenia in Arab populations.
- Author
-
Al-Mendalawi MD, Denic S, and Nicholls GM
- Subjects
- Humans, Arabs, Neutropenia diagnosis
- Published
- 2012
49. A call for screening for benign neutropenia in Arab populations.
- Author
-
Denic S and Nicholls MG
- Subjects
- Adolescent, Adult, Aged, Child, Humans, Middle Aged, Young Adult, Arabs, Neutropenia diagnosis
- Published
- 2011
50. Erythrocyte reference values in Emirati people with and without α+ thalassemia.
- Author
-
Denic S, Souid AK, Nagelkerke N, Showqi S, and Balhaj G
- Abstract
Background: Interpreting the erythroid lineage in populations with high frequency of α+ thalassemia allele is challenging due to the high prevalence of α+ thalassemia homozygotes. For such populations, separate reference values for normal and α+ thalassemia homozygotes are needed., Methods: We studied the erythroid lineage in 1,079 citizens of United Arab Emirates (UAE). Subjects with abnormal hemoglobin (39), iron deficiency (136) or erroneous entries (8) were excluded. MCV distribution in the remaining individuals (896) was visibly bimodal. Statistical mixture analysis with Normix program was used to separate subpopulations with normal and small red cells. Hardy-Weinberg equation was used to estimate genotype frequencies., Results: MCV of 78.0 fl separated phenotype-derived normal homozygotes (715) from phenotype-derived α+ thalassemia homozygotes (181). The erythrocyte indices were significantly different between the two groups (p < 0.0001). The overall prevalence of phenotype-derived α+ thalassemia homozygotes (-α/-α) was 0.20 and markedly varied among tribes, 0 to 0.31 (Mean = 0.15). The frequency of phenotype-derived α+ thalassemia allele was 0.44; when accounting for tribal population structure and inbreeding, the calculated frequency was 0.34. These values were very similar to those found in the same population by genotyping and other phenotyping methods. The erythrocyte reference values for phenotype-derived normal homozygotes in Emiratis closely overlapped with those for Caucasians and normal homozygotes defined by genotyping. The reference values for phenotype-derived α+ thalassemia homozygotes in Emiratis also closely overlapped with those for α+ thalassemia homozygotes defined by genotyping., Conclusion: In populations with frequent α+ thalassemia mutations, two sets of erythrocyte reference values could be determined without genotyping.
- Published
- 2011
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.