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1. Diagnosis and Management of Esophageal Fistulas After Lung Transplantation: A Case Series

Author

Vanstraelen, Stijn, Vos, Robin, Dausy, Marie, Van Slambrouck, Jan, Vanluyten, Cedric, De Leyn, Paul, Coosemans, Willy, Decaluwé, Herbert, Van Veer, Hans, Depypere, Lieven, Bisschops, Raf, Demedts, Ingrid, Casaer, Michael P., Debaveye, Yves, De Vlieger, Greet, Godinas, Laurent, Verleden, Geert, Van Raemdonck, Dirk, Nafteux, Philippe, and Ceulemans, Laurens J.

Published
2024
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4. Lung Transplant Outcome From Selected Older Donors (≥70 Years) Equals Younger Donors (<70 Years): A Propensity-matched Analysis

Author

Vanluyten, Cedric, Vandervelde, Christelle M., Vos, Robin, Van Slambrouck, Jan, Fieuws, Steffen, De Leyn, Paul, Nafteux, Philippe, Decaluwé, Herbert, Van Veer, Hans, Depypere, Lieven, Jansen, Yanina, Provoost, An-Lies, Neyrinck, Arne P., Ingels, Catherine, Vanaudenaerde, Bart M., Godinas, Laurent, Dupont, Lieven J., Verleden, Geert M., Van Raemdonck, Dirk, and Ceulemans, Laurens J.

Published
2023
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5. Lung transplant outcome following donation after euthanasia

Author

Ceulemans, Laurens J., Vanluyten, Cedric, Monbaliu, Diethard, Schotsmans, Paul, Fieuws, Steffen, Vandervelde, Christelle M., De Leyn, Paul, Decaluwé, Herbert, Van Veer, Hans, Depypere, Lieven, Van Slambrouck, Jan, Gunst, Jan, Vanaudenaerde, Bart M., Godinas, Laurent, Dupont, Lieven, Vos, Robin, Verleden, Geert M., Neyrinck, Arne P., and Van Raemdonck, Dirk

Published
2022
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6. Impact of anastomosis time during lung transplantation on primary graft dysfunction

Author

Vandervelde, Christelle M., Vos, Robin, Vanluyten, Cedric, Fieuws, Steffen, Verleden, Stijn E., Van Slambrouck, Jan, De Leyn, Paul, Coosemans, Willy, Nafteux, Philippe, Decaluwé, Herbert, Van Veer, Hans, Depypere, Lieven, Dauwe, Dieter F., De Troy, Erwin, Ingels, Catherine M., Neyrinck, Arne P., Jochmans, Ina, Vanaudenaerde, Bart M., Godinas, Laurent, Verleden, Geert M., Van Raemdonck, Dirk E., and Ceulemans, Laurens J.

Published
2022
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7. Value of [68Ga]Ga-somatostatin receptor PET/CT in the grading of pulmonary neuroendocrine (carcinoid) tumours and the detection of disseminated disease: single-centre pathology-based analysis and review of the literature

Author

Deleu, Anne-Leen, Laenen, Annouschka, Decaluwé, Herbert, Weynand, Birgit, Dooms, Christophe, De Wever, Walter, Jentjens, Sander, Goffin, Karolien, Vansteenkiste, Johan, Van Laere, Koen, De Leyn, Paul, Nackaerts, Kristiaan, and Deroose, Christophe M.

Published
2022
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8. Comparing right- versus left-first implantation in off-pump sequential double-lung transplantation: an observational cohort study.

Author

Slambrouck, Jan Van, Decaluwé, Herbert, Vanluyten, Cedric, Vandervelde, Christelle M, Orlitová, Michaela, Beeckmans, Hanne, Schoenaers, Charlotte, Jin, Xin, Makarian, Roza S, Leyn, Paul De, Veer, Hans Van, Depypere, Lieven, Belmans, Ann, Vanaudenaerde, Bart M, Vos, Robin, Raemdonck, Dirk Van, and Ceulemans, Laurens J

Subjects
*ARTIFICIAL blood circulation, *EXTRACORPOREAL membrane oxygenation, *LUNG transplantation, *INTRAOPERATIVE care, *TRANSPLANTATION of organs, tissues, etc.
Abstract

OBJECTIVES Historically, the perfusion-guided sequence suggests to first transplant the side with lowest lung perfusion. This sequence is thought to limit right ventricular afterload and prevent acute heart failure after first pneumonectomy. As a paradigm shift, we adopted the right-first implantation sequence, irrespective of lung perfusion. The right donor lung generally accommodates a larger proportion of the cardiac output. We hypothesized that the right-first sequence reduces the likelihood of oedema formation in the firstly transplanted graft during second-lung implantation. Our objective was to compare the perfusion-guided and right-first sequence for intraoperative extracorporeal membrane oxygenation (ECMO) need and primary graft dysfunction (PGD). METHODS A retrospective single-centre cohort study (2008–2021) including double-lung transplant cases (N  = 696) started without ECMO was performed. Primary end-points were intraoperative ECMO cannulation and PGD grade 3 (PGD3) at 72 h. Secondary end-points were patient and chronic lung allograft dysfunction-free survival. In cases with native left lung perfusion ≤50% propensity score adjusted comparison of the perfusion-guided and right-first sequence was performed. RESULTS When left lung perfusion was ≤50%, right-first implantation was done in 219 and left-first in 189 cases. Intraoperative escalation to ECMO support was observed in 10.96% of right-first versus 19.05% of left-first cases (odds ratio 0.448; 95% confidence interval 0.229–0.0.878; P  = 0.0193). PGD3 at 72 h was observed in 8.02% of right-first versus 15.64% of left-first cases (0.566; 0.263–1.217; P  = 0.1452). Right-first implantation did not affect patient or chronic lung allograft dysfunction-free survival. CONCLUSIONS The right-first implantation sequence in off-pump double-lung transplantation reduces need for intraoperative ECMO cannulation with a trend towards less PGD grade 3. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Implementation of an enhanced recovery protocol for lung volume reduction surgery: an observational cohort study.

Author

Vandervelde, Christelle M, Everaerts, Stephanie, Weder, Walter, Orolé, Siebe, Hermans, Pieter-Jan, Leyn, Paul De, Nafteux, Philippe, Decaluwé, Herbert, Veer, Hans Van, Depypere, Lieven, Coppens, Steve, Neyrinck, Arne P, Bouneb, Sofian, Coster, Johan De, Coolen, Johan, Dooms, Christophe, Raemdonck, Dirk E Van, Janssens, Wim, and Ceulemans, Laurens J

Subjects
LUNG volume, FORCED expiratory volume, COHORT analysis, SURGICAL complications, POSTOPERATIVE care, CHEST tubes
Abstract

OBJECTIVES Lung volume reduction surgery (LVRS) is an established therapeutic option for advanced emphysema. To improve patients' safety and reduce complications, an enhanced recovery protocol (ERP) was implemented. This study aims to describe and evaluate the short-term outcome of this ERP. METHODS This retrospective single-centre study included all consecutive LVRS patients (1 January 2017 until 15 September 2020). An ERP for LVRS was implemented and stepwise optimised from 1 August 2019, it consisted of changes in pre-, peri- and postoperative care pathways. Patients were compared before and after implementation of ERP. Primary outcome was incidence of postoperative complications (Clavien-Dindo), and secondary outcomes included chest tube duration, incidence of prolonged air leak (PAL), length of stay (LOS) and 90-day mortality. Lung function and exercise capacity were evaluated at 3 and 6 months post-LVRS. RESULTS Seventy-six LVRS patients were included (pre-ERP: n =41, ERP: n =35). The ERP cohort presented with lower incidence of postoperative complications (42% vs 83%, P =0.0002), shorter chest tube duration (4 vs 12 days, P <0.0001) with a lower incidence of PAL (21% vs 61%, P =0.0005) and shorter LOS (6 vs 14 days, P <0.0001). No in-hospital mortality occurred in the ERP cohort versus 4 pre-ERP. Postoperative forced expiratory volume in 1 s was higher in the ERP cohort compared to pre-ERP at 3 months (1.35 vs 1.02 l) and at 6 months (1.31 vs 1.01 l). CONCLUSIONS Implementation of ERP as part of a comprehensive reconceptualisation towards LVRS, demonstrated fewer postoperative complications, including PAL, resulting in reduced LOS. Improved short-term functional outcomes were observed at 3 and 6 months. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Complications related to extracorporeal life support in lung transplantation: single-center analysis

Author

Orlitová, Michaela, primary, Goos, Wout, additional, Van Slambrouck, Jan, additional, Degezelle, Karlien, additional, Vanluyten, Cedric, additional, Vandervelde, Christelle, additional, De Beule, Julie, additional, Jin, Xin, additional, Berkmans, Evelien, additional, De Leyn, Paul, additional, Decaluwé, Herbert, additional, Van Veer, Hans, additional, Depypere, Lieven, additional, Verleden, Geert M., additional, Godinas, Laurent, additional, Vos, Robin, additional, De Troy, Erwin, additional, Dauwe, Dieter F., additional, Ingels, Catherine, additional, Meersseman, Philippe, additional, Hermans, Greet, additional, Wauters, Joost, additional, Rega, Filip, additional, Meyns, Bart, additional, Verbelen, Tom, additional, Van Raemdonck, Dirk E., additional, Neyrinck, Arne P., additional, and Ceulemans, Laurens J., additional

Published
2023
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13. Phenotype molding of stromal cells in the lung tumor microenvironment

Author

Lambrechts, Diether, Wauters, Els, Boeckx, Bram, Aibar, Sara, Nittner, David, Burton, Oliver, Bassez, Ayse, Decaluwé, Herbert, Pircher, Andreas, Van den Eynde, Kathleen, Weynand, Birgit, Verbeken, Erik, De Leyn, Paul, Liston, Adrian, Vansteenkiste, Johan, Carmeliet, Peter, Aerts, Stein, and Thienpont, Bernard

Published
2018
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14. Balancing benefits and risks in lung cancer therapies: patient preferences for lung cancer treatment alternatives

Author

Oliveri, Serena, primary, Lanzoni, Lucilla, additional, Veldwijk, Jorien, additional, de Wit, G. Ardine, additional, Petrocchi, Serena, additional, Janssens, Rosanne, additional, Schoefs, Elise, additional, Smith, Meredith Y., additional, Smith, Ian, additional, Nackaerts, Kristiaan, additional, Vandevelde, Marie, additional, Louis, Evelyne, additional, Decaluwé, Herbert, additional, De Leyn, Paul, additional, Declerck, Hanne, additional, Petrella, Francesco, additional, Casiraghi, Monica, additional, Galli, Giulia, additional, Garassino, Marina Chiara, additional, Girvalaki, Charis, additional, Huys, Isabelle, additional, and Pravettoni, Gabriella, additional

Published
2023
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15. Balancing benefits and risks in lung cancer therapies:patient preferences for lung cancer treatment alternatives

Author

Oliveri, Serena, Lanzoni, Lucilla, Veldwijk, Jorien, de Wit, G. Ardine, Petrocchi, Serena, Janssens, Rosanne, Schoefs, Elise, Smith, Meredith Y., Smith, Ian, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Petrella, Francesco, Casiraghi, Monica, Galli, Giulia, Garassino, Marina Chiara, Girvalaki, Charis, Huys, Isabelle, Pravettoni, Gabriella, Oliveri, Serena, Lanzoni, Lucilla, Veldwijk, Jorien, de Wit, G. Ardine, Petrocchi, Serena, Janssens, Rosanne, Schoefs, Elise, Smith, Meredith Y., Smith, Ian, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Petrella, Francesco, Casiraghi, Monica, Galli, Giulia, Garassino, Marina Chiara, Girvalaki, Charis, Huys, Isabelle, and Pravettoni, Gabriella

Abstract

Background: In the treatment of Non-Small Cell Lung Cancer (NSCLC) the combination of Immuno- Oncotherapy (IO) and chemotherapy (CT) has been found to be superior to IO or CT alone for patients’ survival. Patients and clinicians are confronted with a preference sensitive choice between a more aggressive treatment with a greater negative effect on quality of life versus alternatives that are less effective but have fewer side effects. Objectives: The aims of this study were to: (a) quantify patients’ preferences for relevant attributes related to Immuno-Oncotherapy treatment alternatives, and (b) evaluate the maximum acceptable risk (MAR)/Minimum acceptable benefit (MAB) that patients would accept for treatment alternatives. Methods: An online preference survey using discrete-choice experiment (DCE) was completed by NSCLC patients from two hospitals in Italy and Belgium. The survey asked patients’ preferences for five patient- relevant treatment attributes. The DCE was developed using a Bayesian D-efficient design. DCE analyses were performed using mixed logit models. Information regarding patient demographics, health literacy, locus of control, and quality of life was also collected. Results: 307 patients (158 Italian, 149 Belgian), stage I to IV, completed the survey. Patients preferred treatments with a higher 5-year survival chance as the most important attribute over all the other attributes. Preference heterogeneity for the attribute weights depended on health literacy, patients’ age and locus of control. Patients were willing to accept a substantially increased risks of developing side effects in exchange for the slightest increase (1%) in the chance of surviving at least 5 years from the diagnosis of cancer. Similarly, patients were willing to accept a switch in the mode of administration or complete loss of hair to obtain an increase in survival. Conclusion: In this study, the proportion of respondents who systematically preferred survival over all other

Published
2023

16. Balancing benefits and risks in lung cancer therapies: patient preferences for lung cancer treatment alternatives

Author

HTA Onderzoek Team 1, HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, HEE Team 1, Oliveri, Serena, Lanzoni, Lucilla, Veldwijk, Jorien, de Wit, G Ardine, Petrocchi, Serena, Janssens, Rosanne, Schoefs, Elise, Smith, Meredith Y, Smith, Ian, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Petrella, Francesco, Casiraghi, Monica, Galli, Giulia, Garassino, Marina Chiara, Girvalaki, Charis, Huys, Isabelle, Pravettoni, Gabriella, HTA Onderzoek Team 1, HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, HEE Team 1, Oliveri, Serena, Lanzoni, Lucilla, Veldwijk, Jorien, de Wit, G Ardine, Petrocchi, Serena, Janssens, Rosanne, Schoefs, Elise, Smith, Meredith Y, Smith, Ian, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Petrella, Francesco, Casiraghi, Monica, Galli, Giulia, Garassino, Marina Chiara, Girvalaki, Charis, Huys, Isabelle, and Pravettoni, Gabriella

Published
2023

23. Online Survey Evaluation of Three Years of European Society of Thoracic Surgeons Educational Webinars as Part of The E‐learning Platform

Author

Depypere, Lieven P., primary, Novoa, Nuria, additional, Daddi, Niccolò, additional, Assouad, Jalal, additional, Agrafiotis, Apostolos C., additional, Lauk, Olivia, additional, Decaluwé, Herbert, additional, Falcoz, Pierre Emmanuel, additional, Opitz, Isabelle, additional, Brunelli, Alessandro, additional, and Batirel, Hasan Fevzi, additional

Published
2022
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27. Multicentric evaluation of the impact of central tumour location when comparing rates of N1 upstaging in patients undergoing video-assisted and open surgery for clinical Stage I non-small-cell lung cancer†

Author

Decaluwé, Herbert, Petersen, René Horsleben, Brunelli, Alex, Pompili, Cecilia, Seguin-Givelet, Agathe, Gust, Lucile, Aigner, Clemens, Falcoz, Pierre-Emmanuel, Rinieri, Philippe, Augustin, Florian, Sokolow, Youri, Verhagen, Ad, Depypere, Lieven, Papagiannopoulos, Kostas, Gossot, Dominique, D’Journo, Xavier Benoit, Guerrera, Francesco, Baste, Jean-Marc, Schmid, Thomas, Stanzi, Alessia, Van Raemdonck, Dirk, Bardet, Jeremy, Thomas, Pascal-Alexandre, Massard, Gilbert, Fieuws, Steffen, Moons, Johnny, Dooms, Christophe, De Leyn, Paul, and Hansen, Henrik Jessen

Published
2018
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32. Additional file 1 of Value of [68Ga]Ga-somatostatin receptor PET/CT in the grading of pulmonary neuroendocrine (carcinoid) tumours and the detection of disseminated disease: single-centre pathology-based analysis and review of the literature

Author

Deleu, Anne-Leen, Laenen, Annouschka, Decaluwé, Herbert, Weynand, Birgit, Dooms, Christophe, De Wever, Walter, Jentjens, Sander, Goffin, Karolien, Vansteenkiste, Johan, Van Laere, Koen, De Leyn, Paul, Nackaerts, Kristiaan, and Deroose, Christophe M.

Abstract

Additional file 1. Supplementary Figures.

Published
2022
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33. A Risk Model to Predict the Delivery of Adjuvant Chemotherapy Following Lung Resection in Patients With Pathologically Positive Lymph Nodes

Author

Patella, Miriam, primary, Brunelli, Alessandro, additional, Adams, Laura, additional, Cafarotti, Stefano, additional, Costardi, Lorena, additional, De Leyn, Paul, additional, Decaluwé, Herbert, additional, Franks, Kevin N., additional, Fuentes, Marta, additional, Jimenez, Marcelo F., additional, Karri, Sunanda, additional, Moons, Johnny, additional, Novellis, Pierluigi, additional, Ruffini, Enrico, additional, Veronesi, Giulia, additional, Voulaz, Emanuele, additional, and Shargall, Yaron, additional

Published
2022
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34. Value of [68Ga]Ga-Somatostatin Receptor PET/CT in the Grading of Pulmonary Neuroendocrine (Carcinoid) Tumours and the Detection of Disseminated Disease: Single Center Pathology-Based Analysis and Review of the Literature

Author

Deleu, Anne-Leen, primary, Laenen, Annouschka, additional, Decaluwé, Herbert, additional, Weynand, Birgit, additional, Dooms, Christophe, additional, De Wever, Walter, additional, Jentjens, Sander, additional, Goffin, Karolien, additional, Vansteenkiste, Johan, additional, Laere, Koen Van, additional, De Leyn, Paul, additional, Nackaerts, Kristiaan, additional, and Deroose, Christophe, additional

Published
2022
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43. Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting

Author

Monzani, Dario, primary, Petrocchi, Serena, additional, Oliveri, Serena, additional, Veldwijk, Jorien, additional, Janssens, Rosanne, additional, Bailo, Luca, additional, Smith, Meredith Y., additional, Smith, Ian, additional, Schoefs, Elise, additional, Nackaerts, Kristiaan, additional, Vandevelde, Marie, additional, Louis, Evelyne, additional, Decaluwé, Herbert, additional, De Leyn, Paul, additional, Declerck, Hanne, additional, Katz, Eva G., additional, Petrella, Francesco, additional, Casiraghi, Monica, additional, Durosini, Ilaria, additional, Galli, Giulia, additional, Garassino, Marina Chiara, additional, de Wit, G. Ardine, additional, Pravettoni, Gabriella, additional, and Huys, Isabelle, additional

Published
2021
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44. Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting

Author

Monzani, Dario, Petrocchi, Serena, Oliveri, Serena, Veldwijk, Jorien, Janssens, Rosanne, Bailo, Luca, Smith, Meredith Y., Smith, Ian, Schoefs, Elise, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Katz, Eva G., Petrella, Francesco, Casiraghi, Monica, Durosini, Ilaria, Galli, Guilia, Garassino, Marina Chiara, de Wit, G. Ardine, Pravettoni, Gabriella, Huys, Isabelle, Monzani, Dario, Petrocchi, Serena, Oliveri, Serena, Veldwijk, Jorien, Janssens, Rosanne, Bailo, Luca, Smith, Meredith Y., Smith, Ian, Schoefs, Elise, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Katz, Eva G., Petrella, Francesco, Casiraghi, Monica, Durosini, Ilaria, Galli, Guilia, Garassino, Marina Chiara, de Wit, G. Ardine, Pravettoni, Gabriella, and Huys, Isabelle

Abstract

Background: Advanced treatment options for non-small cell lung cancer (NSCLC) consist of immunotherapy, chemotherapy, or a combination of both. Decisions surrounding NSCLC can be considered as preference-sensitive because multiple treatments exist that vary in terms of mode of administration, treatment schedules, and benefit–risk profiles. As part of the IMI PREFER project, we developed a protocol for an online preference survey for NSCLC patients exploring differences in preferences according to patient characteristics (preference heterogeneity). Moreover, this study will evaluate and compare the use of two different preference elicitation methods, the discrete choice experiment (DCE) and the swing weighting (SW) task. Finally, the study explores how demographic (i.e., age, gender, and educational level) and clinical (i.e., cancer stage and line of treatment) information, health literacy, health locus of control, and quality of life may influence or explain patient preferences and the usefulness of a digital interactive tool in providing information on preference elicitation tasks according to patients. Methods: An online survey will be implemented with the aim to recruit 510 NSCLC patients in Belgium and Italy. Participants will be randomized 50:50 to first receive either the DCE or the SW. The survey will also collect information on participants' disease-related status, health locus of control, health literacy, quality of life, and perception of the educational tool. Discussion: This protocol outlines methodological and practical steps to quantitatively elicit and study patient preferences for NSCLC treatment alternatives. Results from this study will increase the understanding of which treatment aspects are most valued by NSCLC patients to inform decision-making in drug development, regulatory approval, and reimbursement. Methodologically, the comparison between the DCE and the SW task will be valuable to gain information on how these preference methods perform, IMI-PREFER

Published
2021
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45. Patient Preferences for Lung Cancer Treatments:A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting

Author

Monzani, Dario, Petrocchi, Serena, Oliveri, Serena, Veldwijk, Jorien, Janssens, Rosanne, Bailo, Luca, Smith, Meredith Y., Smith, Ian, Schoefs, Elise, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Katz, Eva G., Petrella, Francesco, Casiraghi, Monica, Durosini, Ilaria, Galli, Giulia, Garassino, Marina Chiara, de Wit, G. Ardine, Pravettoni, Gabriella, Huys, Isabelle, Monzani, Dario, Petrocchi, Serena, Oliveri, Serena, Veldwijk, Jorien, Janssens, Rosanne, Bailo, Luca, Smith, Meredith Y., Smith, Ian, Schoefs, Elise, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Katz, Eva G., Petrella, Francesco, Casiraghi, Monica, Durosini, Ilaria, Galli, Giulia, Garassino, Marina Chiara, de Wit, G. Ardine, Pravettoni, Gabriella, and Huys, Isabelle

Abstract

Background: Advanced treatment options for non-small cell lung cancer (NSCLC) consist of immunotherapy, chemotherapy, or a combination of both. Decisions surrounding NSCLC can be considered as preference-sensitive because multiple treatments exist that vary in terms of mode of administration, treatment schedules, and benefit–risk profiles. As part of the IMI PREFER project, we developed a protocol for an online preference survey for NSCLC patients exploring differences in preferences according to patient characteristics (preference heterogeneity). Moreover, this study will evaluate and compare the use of two different preference elicitation methods, the discrete choice experiment (DCE) and the swing weighting (SW) task. Finally, the study explores how demographic (i.e., age, gender, and educational level) and clinical (i.e., cancer stage and line of treatment) information, health literacy, health locus of control, and quality of life may influence or explain patient preferences and the usefulness of a digital interactive tool in providing information on preference elicitation tasks according to patients. Methods: An online survey will be implemented with the aim to recruit 510 NSCLC patients in Belgium and Italy. Participants will be randomized 50:50 to first receive either the DCE or the SW. The survey will also collect information on participants' disease-related status, health locus of control, health literacy, quality of life, and perception of the educational tool. Discussion: This protocol outlines methodological and practical steps to quantitatively elicit and study patient preferences for NSCLC treatment alternatives. Results from this study will increase the understanding of which treatment aspects are most valued by NSCLC patients to inform decision-making in drug development, regulatory approval, and reimbursement. Methodologically, the comparison between the DCE and the SW task will be valuable to gain information on how these preference methods perfo

Published
2021

46. Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting

Author

HEE Team 1, Circulatory Health, JC onderzoeksprogramma Methodologie, Monzani, Dario, Petrocchi, Serena, Oliveri, Serena, Veldwijk, Jorien, Janssens, Rosanne, Bailo, Luca, Smith, Meredith Y, Smith, Ian, Schoefs, Elise, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Katz, Eva G, Petrella, Francesco, Casiraghi, Monica, Durosini, Ilaria, Galli, Giulia, Garassino, Marina Chiara, de Wit, G Ardine, Pravettoni, Gabriella, Huys, Isabelle, HEE Team 1, Circulatory Health, JC onderzoeksprogramma Methodologie, Monzani, Dario, Petrocchi, Serena, Oliveri, Serena, Veldwijk, Jorien, Janssens, Rosanne, Bailo, Luca, Smith, Meredith Y, Smith, Ian, Schoefs, Elise, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Katz, Eva G, Petrella, Francesco, Casiraghi, Monica, Durosini, Ilaria, Galli, Giulia, Garassino, Marina Chiara, de Wit, G Ardine, Pravettoni, Gabriella, and Huys, Isabelle

Published
2021

49. Contributors

Author

Abbott, Andrea M., primary, Abcarian, Herand, additional, Abu-Jaish, Wasef, additional, Adams, David B., additional, Adams, Julie E., additional, Akman, Andrew S., additional, Alberts, Steven R., additional, Ando, Hisami, additional, Armstrong, Leonard, additional, Asamoah, Vivian A., additional, Asgeirsson, Theodor, additional, Ashley, Stanley W., additional, Avgerinos, Dimitrios, additional, Bailey, H. Randolph, additional, Bakhtawar, Humayun, additional, Bandla, Santhoshi, additional, Barlow, John M., additional, Baron, Todd H., additional, Andrade, Juan Camilo Barreto, additional, Bathla, Lokesh, additional, Beaty, Jennifer S., additional, Beck, David E., additional, Beddy, David, additional, Beekley, Alec C., additional, Behrns, Kevin E., additional, Ben-David, Kfir, additional, Bergman, Jacques, additional, Besselink, Marc, additional, Bharucha, Adil E., additional, Billeter, Adrian, additional, Black, Sylvester M., additional, Blatnik, Jeffrey A., additional, Bleday, Ronald, additional, Boland, Brendan J., additional, Boley, Scott J., additional, Bonavina, Luigi, additional, Bonin, Eduardo A., additional, Boostrom, Sarah Y., additional, Bower, Thomas C., additional, Brabender, Jan, additional, Brock, Malcolm V., additional, Buckley, Jill C., additional, Bulsiewicz, William J., additional, Burgess, Adele, additional, Burjonrappa, Sathyaprasad C., additional, Caban, Angel M., additional, Call, Jason A., additional, Callery, Mark P., additional, Cameron, John L., additional, Camilleri, Michael, additional, Carne, Peter W.G., additional, Carr, Jennifer C., additional, Paulson, Emily Carter, additional, Cassim, Riaz, additional, Castell, Donald O., additional, Cataldo, Peter, additional, Cemaj, Samuel, additional, Chandrasoma, Parakrama T., additional, Chang, George J., additional, Chaudhry, Vivek, additional, Chen, Herbert, additional, Cho, Clifford S., additional, Choi, Eugene A., additional, Chojnacki, Karen, additional, Choti, Michael A., additional, Christein, John D., additional, Christensen, Donald O., additional, Chukwumah, Chike V., additional, Chun, Albert K., additional, Cima, Robert R., additional, Clark, Clancy J., additional, Clavien, Pierre-Alain, additional, Cohen, Alfred M., additional, Cohen, Jeffrey, additional, Colquhoun, Steven D., additional, Coosemans, Willy, additional, Coppa, Gene F., additional, Cornwell, Edward E., additional, Cortez, Daniel A., additional, Costantini, Mario, additional, Craig, Daniel A., additional, Crookes, Peter F., additional, Cullen, Joseph J., additional, d’Audiffret, Alexandre, additional, Decaluwé, Herbert, additional, Decker, Georges, additional, Dehn, Thomas C.B., additional, De Leyn, Paul, additional, DeMeester, Steven R., additional, DeMeester, Tom R., additional, Demirjian, Aram N., additional, DeRoss, Anthony L., additional, de Santibañes, Eduardo, additional, Donohue, John H., additional, Dozois, Eric J., additional, Dunkin, Brian J., additional, Dunn, Stephen P., additional, Dunst, Christy M., additional, Duranceau, Andre, additional, Durrani, Noreen, additional, Dutkowski, Philipp, additional, Edil, Barish H., additional, Efron, Jonathan E., additional, El-Gohary, Yousef, additional, Ellison, E. Christopher, additional, Engum, Scott A., additional, Enker, Warren E., additional, Etzioni, David A., additional, Evans, Douglas B., additional, Fazio, Victor W., additional, Felix, Edward L., additional, Fink, Aaron S., additional, Fisher, James, additional, Fitzgibbons, Robert J., additional, Fogel, Evan L., additional, Fong, Yuman, additional, Ford, Debra H., additional, Forgione, Patrick, additional, Fortune, John B., additional, Fritze, Danielle M., additional, Fuchs, Karl-Hermann, additional, Funaki, Brian, additional, Gadacz, Thomas R., additional, Galandiuk, Susan, additional, Geller, David, additional, Gittes, George K., additional, Gitzelmann, Christopher A., additional, Godfrey, Tony E., additional, Goldblatt, Matthew I., additional, Gooszen, Hein G., additional, Gores, Gregory J., additional, Govil, Yogesh, additional, Grant, Kimberly, additional, Greer, Sarah E., additional, Grosfeld, Jay L., additional, Guillem, José G., additional, Hagen, Jeffrey A., additional, Hall, Jason F., additional, Hallemeier, Christopher L., additional, Hallowell, Peter T., additional, Harper, Amy P., additional, Hatzaras, Ioannis S., additional, Haut, Elliott R., additional, Havron, William S., additional, Heitmiller, Richard F., additional, Henderson, J. Michael, additional, Herlong, H. Franklin, additional, Hines, O. Joe, additional, Hirashima, Fuyuki, additional, Hofstetter, Wayne L., additional, Hölscher, Arnulf H., additional, Hompes, Roel, additional, Hoppo, Toshitaka, additional, Huber, Philip J., additional, Hull, Tracy, additional, Hungness, Eric S., additional, Hunter, John G., additional, Huprich, James E., additional, Hussain, Hero K., additional, Hyman, Neil, additional, Irani, Jennifer L., additional, Jackson, Emily T., additional, Jacobs, Danny O., additional, Jensen, Eric H., additional, Jephcott, Catherine, additional, Jobe, Blair A., additional, Johnston, Michael, additional, Jorden, Jeffrey, additional, Joyner, Paul, additional, Julien, Lucas A., additional, Kahrilas, Peter J., additional, Kaleya, Ronald, additional, Kashef, Elika, additional, Katz, Philip, additional, Kent, Tara, additional, Khati, Nadia J., additional, King, Jonathan C., additional, Kissane, Nicole A., additional, Klein, Andrew S., additional, Klinger, Dean E., additional, Knight, Jennifer, additional, Koleilat, Issam, additional, Kozol, Robert, additional, Krantz, Seth B., additional, Ladner, Daniela, additional, Langerman, Alexander, additional, Larson, David W., additional, Law, Simon, additional, Lawler, Leo P., additional, Lazaridis, Konstantinos N., additional, Lee, Yi-Horng, additional, Lee, Yoori, additional, Lefèvre, Jérémie H., additional, Lehman, Glen A., additional, Lerut, Toni, additional, Levi, David M., additional, Lidor, Anne, additional, Liebermann-Meffert, Dorothea, additional, Lillegard, Joseph, additional, Lillemoe, Keith D., additional, Litle, Virginia R., additional, Liu, Donald C., additional, Loftus, Edward V., additional, Lopez-Viego, Miguel, additional, Lord, Reginald V.N., additional, Lowe, Val J., additional, Lurje, Georg, additional, Lyons, Calvin, additional, MacCarty, Robert L., additional, Madoff, Robert D., additional, Maheshwari, Anurag, additional, Mahmoud, Najjia N., additional, Mahvi, David M., additional, Malagó, Massimo, additional, Mannal, Patrick, additional, Marohn, Michael R., additional, Maron, David J., additional, Martz, Joseph E., additional, Mathis, Kellie L., additional, Mathisen, Douglas, additional, Matthews, Jeffrey B., additional, McCahill, Laurence E., additional, McClusky, David A., additional, McFadden, David W., additional, McHenry, Lee, additional, McMurrick, Paul J., additional, Mee, Anthony S., additional, Meilahn, John E., additional, Michelassi, Fabrizio, additional, Miller, Robert C., additional, Miller, Thomas A., additional, Millis, J. Michael, additional, Misawa, Ryosuke, additional, Mittal, Sumeet, additional, Molmenti, Ernesto P., additional, Monson, John R.T., additional, Moore, Jesse, additional, Morgan, Katherine A., additional, Morse, Christopher R., additional, Mortensen, Neil J., additional, Mortenson, Melinda M., additional, Moxon, Ruth, additional, Mulholland, Michael W., additional, Nachmany, Ido, additional, Nafteux, Philippe, additional, Nagorney, David M., additional, Nandakumar, Govind, additional, Natarajan, Bala, additional, Nelson, Heidi, additional, Nicastro, Jeffrey M., additional, Nigam, Ankesh, additional, Nissen, Nicholas N., additional, Norton, Jeffrey A., additional, Nussbaum, Michael, additional, Nyberg, Scott, additional, Öberg, Stefan, additional, Oh, Daniel S., additional, Onesti, Jill K., additional, O’Rourke, Robert W., additional, Oto, Aytekin, additional, Otterson, Mary F., additional, Ouellette, James R., additional, Paidas, Charles N., additional, Pandolfino, John E., additional, Papaconstantinou, Harry T., additional, Pappas, Theodore N., additional, Parc, Yann, additional, Parker, Susan C., additional, Patti, Marco G., additional, Pegoli, Walter, additional, Pemberton, John H., additional, Peters, Jeffrey H., additional, Pham, Thai H., additional, Pillai, Lakshmikumar, additional, Pineda, Carlos E., additional, Pitt, Henry A., additional, Ponsky, Jeffrey L., additional, Posner, Mitchell C., additional, Postier, Russel G., additional, Prabhakaran, Sangeetha, additional, Prachand, Vivek N., additional, Que, Florencia G., additional, Radtke, Arnold, additional, Rai, Rudra, additional, Rakinic, Jan, additional, Rattner, David W., additional, Raymond, Daniel P., additional, Rice, Thomas W., additional, Richardson, J. David, additional, Riegler, Martin, additional, Roberts, John Paul, additional, Roberts, Patricia L., additional, Rodeberg, David A., additional, Roggin, Kevin K., additional, Rolandelli, Rolando, additional, Roman, Sabine, additional, Rosato, Ernest L., additional, Rosen, Michael J., additional, Ross, Andrew, additional, Rushing, Amy P., additional, Sabnis, Adheesh, additional, Saclarides, Theodore J., additional, Sagar, Peter M., additional, Sakorafas, George H., additional, Saltz, Leonard B., additional, Sarin, Shawn N., additional, Sarr, Michael G., additional, Sartorelli, Kennith, additional, Savas, Jeannie F., additional, Schirmer, Bruce, additional, Schmid-Tannwald, Christine, additional, Schneider, John G., additional, Schneider, Paul M., additional, Schnelldorfer, Thomas, additional, Schoetz, David J., additional, Schoppmann, Sebastian, additional, Schröder, Wolfgang, additional, Schulick, Richard D., additional, Senagore, Anthony, additional, Sepesi, Boris, additional, Shaheen, Nicholas J., additional, Sherman, Stuart, additional, Silberstein, Irene, additional, Simmang, Clifford L., additional, Singer, George, additional, Slakey, Douglas P., additional, Smith, Jason, additional, Smith, Jessica K., additional, Snyder, Christopher W., additional, Sonnenday, Christopher J., additional, Soper, Nathaniel J., additional, Sotiropoulos, George C., additional, Spechler, Stuart Jon, additional, Stanley, Andrew, additional, Statter, Mindy B., additional, Steele, Kimberley E., additional, Steinhagen, Emily, additional, Stocchi, Luca, additional, Sudakoff, Gary, additional, Sundaram, Abhishek, additional, Sundaram, Magesh, additional, Swanström, Lee L., additional, Swartz, Daniel E., additional, Takada, Tadahiro, additional, Tamm, Eric P., additional, Tavakkolizadeh, Ali, additional, Telford, Gordon L., additional, Thacker, Julie K. Marosky, additional, Theodoropoulos, Dimitra G., additional, Thomas, Michael S., additional, Thorson, Alan G., additional, Thurston, Kristy, additional, Tichansky, David S., additional, Tomizawa, Yutaka, additional, Traverso, L. William, additional, Trus, Thadeus, additional, Tsai, Susan, additional, Tsikitis, Vassiliki Liana, additional, Tsoraides, Steven, additional, Tutuian, Radu, additional, Tzakis, Andreas G., additional, Vallböhmer, Daniel, additional, Raemdonck, Dirk Van, additional, van Santvoort, Hjalmar, additional, Venbrux, Anthony C., additional, Vickers, Selwyn M., additional, Villar, Hugo V., additional, Villegas, Leonardo, additional, Wallace, James R., additional, Wallace, William D., additional, Wang, Huamin, additional, Wang, Kenneth K., additional, Watkins, James L., additional, Watson, Thomas J., additional, Waxman, Irving, additional, Weiser, Martin R., additional, Welch, John, additional, Welton, Mark L., additional, Wexner, Steven D., additional, White, Rebekah R., additional, Wick, Elizabeth C., additional, Wilson, Alison, additional, Winslow, Emily, additional, Witkowski, Piotr, additional, Wolff, Bruce G., additional, Wolfgang, Christopher L., additional, Wong, W. Douglas, additional, Worsey, Jonathan, additional, Wright, Cameron D., additional, Yadav, Bhupender, additional, Yeo, Charles J., additional, Yeung, Trevor M., additional, Yezhelyev, Max, additional, Yoo, Kyo-Sang, additional, You, Yi-Qian Nancy, additional, Young-Fadok, Tonia M., additional, Zacherl, Johannes, additional, Zaninotto, Giovanni, additional, Zeman, Merissa N., additional, Zimmerman, Pamela, additional, and Zuccaro, Gregory, additional

Published
2013
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