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16 results on '"De Nisco, Carlo"'

2. Expression levels of circulating miRNAs as biomarkers during multimodal treatment of rectal cancer - TiMiSNAR-mirna: a substudy of the TiMiSNAR Trial (NCT03962088)

Author

Monsellato, Igor, Garibaldi, Elisabetta, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Elmore, Ugo, Delpini, Roberto, Rosati, Riccardo, Perinotti, Roberto, Alongi, Filippo, Bertocchi, Elisa, Gori, Stefania, Ruffo, Giacomo, Pernazza, Graziano, Pulighe, Fabio, De Nisco, Carlo, Morpurgo, Emilio, Contardo, Tania, Mammano, Enzo, Perna, Federico, Menegatti, Benedetta, Coratti, Andrea, Buccianti, Piero, Balestri, Riccardo, Ceccarelli, Cristina, Cavaliere, Davide, Solaini, Leonardo, Ercolani, Giorgio, Traverso, Elena, Fusco, Vittorio, Torri, Valter, and Orecchia, Sara

Published
2020
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3. Clinical outcomes and quality of life associated with the use of a biosynthetic mesh for complex ventral hernia repair: analysis of the “Italian Hernia Club” registry

Author

Rognoni, Carla, Cuccurullo, Diego, Borsoi, Ludovica, Bonavina, Luigi, Asti, Emanuele, Crovella, Feliciano, Bassi, Uberto Andrea, Carbone, Gabriele, Guerini, Francesca, De Paolis, Paolo, Pessione, Silvia, Greco, Vincenzo Maria, Baccarini, Elisabetta, Soliani, Giorgio, Sagnelli, Carlo, Crovella, Clotilde, Trapani, Vincenzo, De Nisco, Carlo, Eugeni, Emilio, Zanzi, Federico, De Nicola, Enrico, Marioni, Antonio, Rosignoli, Alessandro, Silvestro, Roberto, Tarricone, Rosanna, and Piccoli, Micaela

Published
2020
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4. Correction to: Standard (8 weeks) vs long (12 weeks) timing to minimally-invasive surgery after NeoAdjuvant Chemoradiotherapy for rectal cancer: a multicenter randomized controlled parallel group trial (TiMiSNAR)

Author

Monsellato, Igor, Alongi, Filippo, Bertocchi, Elisa, Gori, Stefania, Ruffo, Giacomo, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Pernazza, Graziano, Pulighe, Fabio, De Nisco, Carlo, Perinotti, Roberto, Morpurgo, Emilio, Contardo, Tania, Mammano, Enzo, Elmore, Ugo, Delpini, Roberto, Rosati, Riccardo, Perna, Federico, Coratti, Andrea, Menegatti, Benedetta, Gentilli, Sergio, Baroffio, Paolo, Buccianti, Piero, Balestri, Riccardo, Ceccarelli, Cristina, Torri, Valter, Cavaliere, Davide, Solaini, Leonardo, Ercolani, Giorgio, Traverso, Elena, Fusco, Vittorio, Rossi, Maura, Priora, Fabio, Numico, G., Franzone, Paola, and Orecchia, Sara

Published
2020
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5. Standard (8 weeks) vs long (12 weeks) timing to minimally-invasive surgery after NeoAdjuvant Chemoradiotherapy for rectal cancer: a multicenter randomized controlled parallel group trial (TiMiSNAR)

Author

Monsellato, Igor, Alongi, Filippo, Bertocchi, Elisa, Gori, Stefania, Ruffo, Giacomo, Cassinotti, Elisa, Baldarti, Ludovica, Boni, Luigi, Pernazza, Graziano, Pulighe, Fabio, De Nisco, Carlo, Perinotti, Roberto, Morpurgo, Emilio, Contardo, Tania, Mammano, Enzo, Elmore, Ugo, Delpini, Roberto, Rosati, Riccardo, Perna, Federico, Coratti, Andrea, Menegatti, Benedetta, Gentilli, Sergio, Baroffio, Paolo, Buccianti, Piero, Balestri, Riccardo, Ceccarelli, Cristina, Torri, Valter, Cavaliere, Davide, Solaini, Leonardo, Ercolani, Giorgio, Traverso, Elena, Fusco, Vittorio, Rossi, Maura, Priora, Fabio, Numico, G., Franzone, Paola, and Orecchia, Sara

Published
2019
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6. Laparoscopic appendectomy vs antibiotic therapy for acute appendicitis: a propensity score-matched analysis from a multicenter cohort study

Author

Poillucci, Gaetano, Mortola, Lorenzo, Podda, Mauro, Di Saverio, Salomone, Casula, Laura, Gerardi, Chiara, Cillara, Nicola, Presenti, Luigi, Balestra, Francesco, Serventi, Fernando, Fiume, Stefania, D Lai, M Antonio, Ledda, Simona, Pulighe, Fabio, Gobbi, Sara, De Nisco, Carlo, Argenio, Giulio, Norcia, Giorgio, Gemini, Sergio, Sechi, Raffaele, Pala, Miriam, Pau, Renata, Ottonello, Roberto, Pisano, Marcello, Aresu, Simona, Coppola, Massimiliano, Tuveri, Antonio, Madeddu, Francesco, Piredda, Antonella, Pinna, Giovanni, Scognamillo, Fabrizio, Tilocca, PierLuigi, Delogu, Leonardo, Carboni, Gian Marco, Porcu, Gianfranco, Piras, Danilo, and The ACTUAA-R Collaborative Working Group on Acute Appendicitis

Published
2017
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7. A prospective non-randomized controlled, multicenter trial comparing Appendectomy and Conservative Treatment for Patients with Uncomplicated Acute Appendicitis (the ACTUAA study)

Author

Podda, Mauro, Serventi, Fernando, Mortola, Lorenzo, Marini, Stefano, Sirigu, Danilo, Piga, Michela, Pisano, Marcello, Coppola, Massimiliano, Agresta, Ferdinando, Virdis, Francesco, Di Saverio, Salomone, Cillara, Nicola, Balestra, Francesco, Ottonello, Roberto, Lai, Antonio, Piro, Silverio, Argenio, Giulio, Gemini, Sergio, Pala, Miriam, Piras, Mario, Erdas, Enrico, Nicolosi, Angelo, Gordini, Luca, Podda, Francesco, Pisanu, Adolfo, Atzeni, Jenny, Poillucci, Gaetano, De Nisco, Carlo, Casciu, Luigi, Piano, Maurizio, Labate, Salvatore, Saba, Luca, Aresu, Simona, Azzinnaro, Antonio, Ioia, Giovanna, Turri, Luciano, Pulighe, Fabio, Anania, Marco, Canfora, Alfonso, Bottino, Vincenzo, Piazza, Diego, Luridiana, Gianluigi, Serra, Piergiorgio, Saba, Alessandra, Tuveri, Antonio, Pinna, Giovanni, Piredda, Antonella, Madeddu, Francesco, Caneva, Patrizia Dalla, Delogu, Daniele, Saliu, Antonella, Cogoni, Gianfranco, Deserra, Antonello, Pau, Renata, Cossu, Sergio, Canu, Luisa, Marcias, Gianni, Garau, Franco, Loi, Salvatore, Bellisano, Giulia, Presenti, Luigi, Maccioni, Antonio, Norcia, Giorgio, Piras, Emanuele, Fiume, Stefania, Pitzalis, Antonella, Bianco, Paola, Cappai, Mariangela, Cadeddu, Flavio Nicola, Manca, Alessandra, Occhioni, Giovanni, Rossi, Arianna Magoni, Rizzo, Salvatore, Centonze, Maurizio, Portolano, Vincenzo, Barbareschi, Mattia, Barrasi, Elena, Martorana, Martina, Ferro, Franca, Casarini, Claudia, Stella, Giorgio, Generoso, Paola, Rossi, Sabina, Abelli, Fabrizio, Casula, Laura, Gerardi, Chiara, Bertele’, Vittorio, and The ACTUAA Study Collaborative Working Group

Published
2017
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8. Robotic versus laparoscopic transabdominal preperitoneal (TAPP) approaches to bilateral hernia repair: a multicenter retrospective study using propensity score matching analysis

Author

Peltrini, Roberto, primary, Corcione, Francesco, additional, Pacella, Daniela, additional, Castiglioni, Simone, additional, Lionetti, Ruggero, additional, Andreuccetti, Jacopo, additional, Pignata, Giusto, additional, De Nisco, Carlo, additional, Ferraro, Luca, additional, Salaj, Adelona, additional, Formisano, Giampaolo, additional, Bianchi, Paolo Pietro, additional, and Bracale, Umberto, additional

Published
2022
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10. Appendectomy versus conservative treatment with antibiotics for patients with uncomplicated acute appendicitis: a propensity score–matched analysis of patient-centered outcomes (the ACTUAA prospective multicenter trial).

Author

Podda, Mauro, Poillucci, Gaetano, Pacella, Daniela, Mortola, Lorenzo, Canfora, Alfonso, Aresu, Simona, Pisano, Marcello, Erdas, Enrico, Pisanu, Adolfo, Cillara, Nicola, The ACTUAA Study Collaborative Working Group, Serventi, Fernando, Marini, Stefano, Sirigu, Danilo, Piga, Michela, Coppola, Massimiliano, Balestra, Francesco, De Nisco, Carlo, Pazzona, Marco, and Anania, Marco

Abstract

Purpose: The aim of this prospective multicenter study was to compare antibiotic therapy and appendectomy as treatment for patients with uncomplicated appendicitis confirmed by ultrasound and/or computed tomography. Methods: The study was conducted from January 2017 to January 2018. Data regarding all patients discharged from the participating centers with a diagnosis of uncomplicated appendicitis were collected prospectively. Results: Of the 318 patients enrolled in the study, 27.4% underwent antibiotic-first therapy, and 72.6% underwent appendectomy. The matched group was composed of 87 patients in both study arms. Of the 87 patients available of 1-year follow-up in the antibiotic-first group, 64 (73.6%) did not require appendectomy. The complication-free treatment success in the antibiotic-first group was 64.4%. A statistically significant higher complication-free treatment success was found in the appendectomy group: 81.8% in the pre-matching sample and 83.9% in the post-matching sample. Patients in the antibiotic-first group reported lower VAS scores compared to those treated with an appendectomy, both at discharge (2.0 ± 1.7 vs 3.6 ± 2.3) and at 30-day follow-up (0.3 ± 0.6 vs 2.1 ± 1.7). The mean of the days of absence from work was higher in the appendectomy group (β 0.63; 95% CI 0.08–1.18). Conclusion: Although laparoscopic appendectomy remains the gold standard of treatment for uncomplicated appendicitis, conservative treatment with antibiotics is a safe option in most cases. Approximately 65% of patients treated with antibiotics are symptom-free at 1 year, without increased risk of adverse events should symptoms recur, and better outcomes in terms of less pain and shorter period of absence from work compared to patients undergoing an appendectomy. Trial registration: Clinicaltrials.gov identifier (NCT number): NCT03080103 [ABSTRACT FROM AUTHOR]

Published
2021
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14. A bleeding umbilical mass

Author

Guerra, Francesco, primary, Pulighe, Fabio, additional, Sacchetti, Riccardo, additional, Serra, Stefano, additional, and De Nisco, Carlo, additional

Published
2015
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15. Correction to: Appendectomy versus conservative treatment with antibiotics for patients with uncomplicated acute appendicitis: a propensity score–matched analysis of patient-centered outcomes (the ACTUAA prospective multicenter trial).

Author

Podda, Mauro, Poillucci, Gaetano, Pacella, Daniela, Mortola, Lorenzo, Canfora, Alfonso, Aresu, Simona, Pisano, Marcello, Erdas, Enrico, Pisanu, Adolfo, Cillara, Nicola, Serventi, Fernando, Marini, Stefano, Sirigu, Danilo, Piga, Michela, Coppola, Massimiliano, Balestra, Francesco, De Nisco, Carlo, Pazzona, Marco, Anania, Marco, and Pulighe, Fabio

Abstract

A Correction to this paper has been published: https://doi.org/10.1007/s00384-021-03862-5 [ABSTRACT FROM AUTHOR]

Published
2021
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16. Expression levels of circulating miRNAs as biomarkers during multimodal treatment of rectal cancer - TiMiSNAR-mirna: A substudy of the TiMiSNAR Trial (NCT03962088)

Author

Giorgio Ercolani, Elisabetta Garibaldi, Leonardo Solaini, Ugo Elmore, Tania Contardo, Roberto Perinotti, C Ceccarelli, Igor Monsellato, Luigi Boni, Riccardo Rosati, Fabio Pulighe, Ludovica Baldari, Enzo Mammano, Sara Orecchia, Giacomo Ruffo, Riccardo Balestri, Valter Torri, Graziano Pernazza, Elena Traverso, Stefania Gori, Benedetta Menegatti, Davide Cavaliere, Vittorio Fusco, Elisa Cassinotti, Carlo De Nisco, Piero Buccianti, Filippo Alongi, Federico Perna, Roberto Delpini, Andrea Coratti, Emilio Morpurgo, Elisa Bertocchi, Monsellato I., Garibaldi E., Cassinotti E., Baldari L., Boni L., Elmore U., Delpini R., Rosati R., Perinotti R., Alongi F., Bertocchi E., Gori S., Ruffo G., Pernazza G., Pulighe F., De Nisco C., Morpurgo E., Contardo T., Mammano E., Perna F., Menegatti B., Coratti A., Buccianti P., Balestri R., Ceccarelli C., Cavaliere D., Solaini L., Ercolani G., Traverso E., Fusco V., Torri V., Orecchia S., Monsellato, Igor, Garibaldi, Elisabetta, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Elmore, Ugo, Delpini, Roberto, Rosati, Riccardo, Perinotti, Roberto, Alongi, Filippo, Bertocchi, Elisa, Gori, Stefania, Ruffo, Giacomo, Pernazza, Graziano, Pulighe, Fabio, De Nisco, Carlo, Morpurgo, Emilio, Contardo, Tania, Mammano, Enzo, Perna, Federico, Menegatti, Benedetta, Coratti, Andrea, Buccianti, Piero, Balestri, Riccardo, Ceccarelli, Cristina, Cavaliere, Davide, Solaini, Leonardo, Ercolani, Giorgio, Traverso, Elena, Fusco, Vittorio, Torri, Valter, and Orecchia, Sara

Subjects
Oncology, medicine.medical_specialty, Neoadjuvant treatment, Colorectal cancer, Medicine (miscellaneous), Disease, Disease-Free Survival, 03 medical and health sciences, Study Protocol, 0302 clinical medicine, Internal medicine, medicine, Humans, Pharmacology (medical), Liquid biopsy, Lymph node, Grading (tumors), Pathological, 030304 developmental biology, Neoplasm Staging, Randomized Controlled Trials as Topic, Retrospective Studies, miRNA, 0303 health sciences, lcsh:R5-920, business.industry, Rectal Neoplasms, Chemoradiotherapy, Biomarker, Translational research, medicine.disease, Combined Modality Therapy, Neoadjuvant Therapy, Biomarkers, MicroRNAs, Observational Studies as Topic, medicine.anatomical_structure, Treatment Outcome, 030220 oncology & carcinogenesis, Histopathology, business, lcsh:Medicine (General)
Abstract

Background Neoadjuvant chemoradiotherapy followed by surgery is the mainstay treatment for locally advanced rectal cancer, leading to significant decrease in tumor size (downsizing) and a shift towards earlier disease stage (downstaging). Extensive histopathological work-up of the tumor specimen after surgery including tumor regression grading and lymph node status helped to visualize individual tumor sensitivity to chemoradiotherapy, retrospectively. As the response to neoadjuvant chemoradiotherapy is heterogeneous, however, valid biomarkers are needed to monitor tumor response. A relevant number of studies aimed to identify molecular markers retrieved from tumor tissue while the relevance of blood-based biomarkers is less stringent assessed. MicroRNAs are currently under investigation to serve as blood-based biomarkers. To date, no screening approach to identify relevant miRNAs as biomarkers in blood of patients with rectal cancer was undertaken. The aim of the study is to investigate the role of circulating miRNAs as biomarkers in those patients included in the TiMiSNAR Trial (NCT 03465982). This is a biomolecular substudy of TiMiSNAR Trial (NCT03962088). Methods All included patients in the TiMiSNAR Trial are supposed to undergo blood collection at the time of diagnosis, after neoadjuvant treatment, after 1 month from surgery, and after adjuvant chemotherapy whenever indicated. Discussion TiMiSNAR-MIRNA will evaluate the association of variation between preneoadjuvant and postneoadjuvant expression levels of miRNA with pathological complete response. Moreover, the study will evaluate the role of liquid biopsies in the monitoring of treatment, correlate changes in expression levels of miRNA following complete surgical resection with disease-free survival, and evaluate the relation between changes in miRNA during surveillance and tumor relapse. Trial registration Clinicaltrials.gov NCT03962088. Registered on 23 May 2019.

Published
2020

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