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Patients with advanced gastric cancer experience rapid disease progression with limited survival, high mortality, and a lack of surgical options. Thus, radiochemotherapy or a combination of chemotherapeutics with targeted therapy is the mainstay of treatment. In comparison to the treatment of other malignant tumors, in gastric cancer, the development of molecularly targeted drugs has been relatively slow. Currently, there are two major classes of molecularly targeted drug regimens that have achieved a certain efficacy in clinical practice: anti-vascular endothelial growth factor (anti-VEGF) therapy and anti-epidermal growth factor receptor (anti-EGFR) therapy. Trastuzumab has been approved as the standard of care for first-line treatment in advanced human epidermal growth factor receptor 2 (HER2)-positive gastric cancer. Ramucirumab in combination with paclitaxel is the recommended regimen for second-line treatment, and apatinib is recommended as third-line treatment. This review summarizes the current status of targeted therapies in the treatment of gastric cancer and gives a perspective on the future.

Oxaliplatin is a first-line clinical drug in cancer treatment and its side effects of peripheral neuropathic pain have also attracted much attention. Neuroinflammation induced by oxidative stress-mediated activation of nuclear factor-kappa B (NF-κB) plays an important role in the course. Current studies have shown that curcumin has various biological activities like antioxidant, anti-inflammatory, antitumor and so on, while few studies were conducted about its role in oxaliplatin-induced peripheral neuropathic pain. The aim of this study is to verify the mechanism of curcumin alleviating oxaliplatin-induced peripheral neuropathic pain. Intraperitoneal injection with oxaliplatin (4 mg/kg body weight) was given to the rats twice a week and last for four weeks to establish the model rats. Gavage administration of curcumin (12.5, 25, and 50 mg/kg body weight, respectively) was conducted for consecutive 28 d to explore the effects and potential mechanism. Our results showed that curcumin administration could increase mechanical withdrawal threshold and decrease the paw-withdrawal times of cold allodynia significantly; meanwhile, motor nerve conduction velocity (MNCV) and sense nerve conduction velocity (SNCV) were both increased and the injured neurons of the spinal cord were repaired. In addition, curcumin administration increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and reduced malondialdehyde (MDA). Moreover, the curcumin operation inhibited the activated of NF-κB and level of inflammatory factors like tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). In conclusion, these findings suggested that curcumin could alleviate oxaliplatin-induced peripheral neuropathic pain; the mechanism might be inhibiting oxidative stress-mediated activation of NF-κB and mitigating neuroinflammation.

Session Initiation Protocol (SIP) is the most widely used signalling protocol for controlling communication, establishing, maintaining, and terminating sessions on the Internet. However, since sensitive information is often transmitted through open channels, a security authentication scheme is essential. Recently, Islam et al. proposed an authentication scheme for SIP, and argued that the scheme is immune to known attacks. However, we discover that their scheme fails to achieve user anonymity, and it cannot even resist impersonation attack. Therefore, this study proposes an enhanced mutual authentication scheme to eliminate the drawbacks of the scheme proposed by Islam et al. In addition, our proposed scheme is based on extended chaotic map, which avoids computationally expensive elliptic curve point multiplication. Then, we use Burrows-Abadi-Needham logic to prove that the proposed scheme achieves secure mutual authentication, and we use the Real-Or-Random model to analyze the formal security verification of the session key. Finally, we compare the performance and the security features of the proposed scheme with some existing schemes. Therefore, we provide better safety and efficiency than related schemes and the proposed scheme is suitable for SIP.

Ziyin Huatan Recipe (ZYHT), a traditional Chinese medicine comprised of Lilii Bulbus, Pinelliae Rhizoma, and Hedyotis Diffusa, has shown promise in treating gastric cancer (GC). However, its potential mechanism has not yet been clearly addressed. This study aimed to predict targets and molecular mechanisms of ZYHT in treating GC by network pharmacology analysis and to explore the role of ZYHT in GC both in vitro and in vivo.Targets and molecular mechanisms of ZYHT were predicted via network pharmacology analysis. The effects of ZYHT on the expression of metastasis-associated targets were further validated by Western blot and quantitative real-time polymerase chain reaction. To explore the specific molecular mechanisms of the effects of ZYHT on migration and invasion, the runt-related transcription factor 3 (RUNX3) gene was knocked out by clustered regularly interspaced short palindromic repeats/Cas9, and lentiviral vectors were transfected into SGC-7901 cells. Then lung metastasis model of GC in nude mice was established to explore the anti-metastasis effect of ZYHT. Western blot and immunohistochemistry were used to explore the impact of ZYHT on the expression of metastasis-related proteins with or without RUNX3 gene.The network pharmacology analysis showed that ZYHT might inhibit focal adhesion, migration, invasion and metastasis of GC. ZYHT inhibited the proliferation, migration and invasion of GC cells in vitro via regulating the expression of metastasis-associated targets. Knocking out RUNX3 almost completely reversed the cell phenotypes (migration and invasion) and protein expression levels elicited by ZYHT. In vivo studies showed that ZYHT inhibited the metastasis of GC cells to the lung and prolonged the survival time of the nude mice. Knocking out RUNX3 partly reversed the metastasis of GC cells to the lung and the protein expression levels elicited by ZYHT.ZYHT can effectively inhibit the invasion and migration of GC in vitro and in vivo, and its molecular mechanism may relate to the upregulation of RUNX3 expression.

The advanced encryption standard (AES) is the most encryption algorithm used around the world. This fact made it coveted by several cryptanalysis attacks. Some of them succeed to reveal certain weakness, due to its static parameters known by the public mass. The substitution box (S-Box) is among the most sensitive parameters of this standard, which plays a crucial role in the protection against these attacks. In this study, a new version of AES is introduced, which uses a set of AES-like S-Boxes instead of the original one. These S-Boxes, generated from different irreducible polynomials, are dynamically chosen, depending on the encryption key. This introduction is conducted by the design and the implementation of a new block cipher version of AES, based on a key dependent S-Box cube. Where a cube of six interchangeable S-Boxes key-dependently generated is constructed. This cube determines the active S-Box for a given round, through its random rotations guided by the round key. Furthermore, the improvement of the cryptographic robustness, provided by this method is demonstrated. This is accomplished through a comparison with the original AES, in terms of statistical and cryptographic randomness properties.

A basic but expensive operation in the implementations of several famous public-key cryptosystems is the computation of the multi-scalar multiplication in a certain finite additive group defined by an elliptic curve. We propose an adaptive window method for the multi-scalar multiplication, which aims to balance the computation cost and the memory cost under register-constrained environments. That is, our method can maximize the computation efficiency of multi-scalar multiplication according to any small, fixed number of registers provided by electronic devices. We further demonstrate that our method is efficient when five registers are available. Our method is further studied in detail in the case where it is combined with the non-adjacent form (NAF) representation and the joint sparse form (JSF) representation. One efficiency result is that our method with the proposed improved NAF n-bit representation on average requires 209n/432 point additions. To the best of our knowledge, this efficiency result is optimal compared with those of similar methods using five registers. Unlike the previous window methods, which store all possible values in the window, our method stores those with comparatively high probabilities to reduce the number of required registers.

As an open standard for the short-range radio frequency communications, Bluetooth is suitable for Mobile Crowdsensing Systems (MCS). However, the massive deployment of personal Bluetooth-enabled devices also raises privacy concerns on their wielders. Hence, we investigate the privacy of the unilateral authentication protocol according to the recent Bluetooth standard v5.2. The contributions of the paper are twofold. (1) We demonstrate that the unilateral authentication protocol suffers from privacy weakness. That is, the attacker is able to identify the target Bluetooth-enabled device once he observed the device’s previous transmitted messages during the protocol run. More importantly, we analyze the privacy threat of the Bluetooth MCS, when the attacker exploits the proposed privacy weakness under the typical Internet of Things (IoT) scenarios. (2) An improved unilateral authentication protocol is therefore devised to repair the weakness. Under our formal privacy model, the improved protocol provably solves the traceability problem of the original protocol in the Bluetooth standard. Additionally, the improved protocol can be easily adapted to the Bluetooth standards because it merely employs the basic cryptographic components available in the standard specifications. In addition, we also suggest and evaluate two countermeasures, which do not need to modify the original protocol.

Background/Aims. In previous studies, it has been observed that Xiaotan Jieyu (XTJY) prescription may inhibit the proliferation of human breast precancerous lesion MCF-10AT cells by inhibiting the PI3K/Akt signaling pathway. The purpose of this study is to further verify the therapeutic effect and the possible mechanism of XTJY on precancerous lesions of breast cancer in vivo. Methods. The successfully established breast precancerous lesion rat model and normal healthy rats were randomly assigned into the blank (BLA), model (MOD), XTJY-low (LD), XTJY-medium (MD), XTJY-high (HD), and tamoxifen (TAM) groups. Different concentrations of XTJY and saline were supplied by intragastric administration for 4 consecutive weeks to assess the protective effect of XTJY on the progress of the breast precancerous lesion in rats involving the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Results. In this study, it determined that 10 mg/each rat DMBA-combined estrogen and progesterone induction for 10 weeks was the optimal condition for the establishment of the breast precancerous lesion rat model. In vivo administration of XTJY or TAM was found to inhibit the development of the breast precancerous lesion, and the occurrence rate of breast invasive carcinomas was decreased by about 50%. Furthermore, XTJY or TAM markedly reduced protein expressions of PI3K and p-Akt and increased protein expressions of PTEN. Conclusion. These data indicated that XTJY can significantly alleviate the development of breast precancerous lesions by inhibiting the activation of the PI3K/Akt signaling pathway. XTJY may be a promising drug for the treatment of precancerous lesions in breast cancer.

Liu et al. proposed a grouping-proof authentication protocol (GUPA) for distributed radio frequency identification systems. At the same time, Liu et al. claimed that GUPA can resist the well-known attacks such as replay, forgery, tracking, and denial of proof. However, we report that, according to Liu et al. ’s assumption of the attack ability, the attacker is able to compromise all secrets by the man-in-the-middle (MIM) attacks. Although the MIM attacks were not explicitly evaluated by GUPA, the attacker can easily launch replay, forgery, tracking, and denial of proof when he knows all secrets of GUPA. That is, the lethal security flaws exist in GUPA. We also suggest employing the cryptographic hash function to protect the secrets in GUPA. Our security analysis of GUPA will be beneficial to the design of the robust grouping-proof authentication protocols in the future.

Multiple direction compression (MDC) was conducted on sintered pure tungsten (99.9%, mass fraction) with different reductions at 1423 K. The microstructure, microhardness and thermal stability of the MDC-processed samples were studied by X-ray diffraction (XRD), electron backscattered diffraction (EBSD) and differential scanning calorimetry (DSC) compared with those of the initial sintered tungsten. The results show that the dislocation density increases significantly with the reduction of MDC, ranging from 3.08×1014 m–2 for the initial sintered tungsten to 8.08×1014 m–2 for the tungsten after MDC with the reduction of 50%. The average grain size decreases from 83.8 to 14.7 μm and the microhardness value increases from HV0.2 417 to HV0.2 521. The recrystallization temperature for the tungsten samples processed by MDC is approximately constant at around 1600 K. The MDC of sintered tungsten results in a decrease of grain size concurrent with an increase of uniformly distributed nucleation sites, which leads to the improvement of the thermal stability.

Numerous attempts have been made to improve the existing intersection systems to maximize capacity and reduce the delay costs and queues. This paper introduces a simulation method to study the effectiveness of a new technique introduced recently in China – the left-turn waiting area. This has an extended left lane that allows the vehicles to wait before the signal turns green. It is reported that this system can significantly improve intersection performance. This paper introduces the different types of left-turn waiting areas which have been widely implemented in China. The method of using micro-simulation VISSIM to study the effectiveness of left-turn waiting area is proposed in this paper, along with some preliminary results of a case study.

Lead-free EO ceramics have been received increasing attentions from the view point of green environment in recent years. In this study, lead-free Ba6-1.5xLaxTi2Nb8O30 (0≤x≤7%) ceramics were synthesized by the conventional solid state reaction sintering method. The effects of lanthanum doping on the microstructure and electrical properties of Ba6Ti2Nb8O30 (BTN) ceramics were investigated and analyzed. The XRD results revealed that the lanthanum doping changed the BTN lattice parameters slightly. The sample grain size, dielectric constants (1kHz) and the temperature Tm gradually decreased with the increasing of lanthanum doped content. The optimized BLTN ceramic sample with x=4 mol % exhibited a good transparency and excellent electrical properties (Ps=6.41 μC/cm2, Pr=0.77 μC/cm2, and Ec=3.80 kV/cm).

Objective To investigate the effcts of methylnitronitrosoguanidine (MNNG) on the malignant transformation of human gastric mucosa GES-1 cells and explore the possible molecular mechanism. Methods The GES-1 cells was treated by 9 different concentrations of MNNG for 24h, then removed MNNG and culture cell normally. The cell proliferation was detected by CCK-8 assay after 24h. The effects of MNNG on invasion and migration ability were detected by Transwell invasion and migration tests after 24h. The apoptosis was detected by Annexin V-FITC/PI FCM after 48h, and the expression levels of NF-κB p65 mRNA and protein were measured by real-time fluorescent quantitative PCR and Western blotting respectively. Results 2×10–4mol/L MNNG was chose for the induction of malignant transformation of GES -1 cells by the statistic analysis, 2×104mol/L MNNG could increase the proliferation, promote the invasion and migration, suppress the apoptosis of GES-1 cells (P

In this article, we introduce a new concept of oblivious transfer with membership verification that allows any legitimate group users to obtain services from a service provider in an oblivious manner. We present two oblivious transfer with membership verification schemes, differing in design. In the first scheme, a trusted group manager issues credentials for a pre-determined group of users so that the group of users with a valid group credential can obtain services from the service provider, while the choices made by group users remain oblivious to the service provider. The second scheme avoids the trusted group manager, which allows any user in the group to be a group manager, thus it is more suitable in distributed systems. In particular, we prove that the two oblivious transfer with membership verification schemes can achieve receiver’s privacy and sender’s privacy under a half-simulation model.

Srivastava et al., recently proposed a hash based mutual RFID authentication protocol. They claimed that the protocol can provide several attractive security features, i.e., the mutual authentication and the resistance against the eavesdropping and tracing attack, the replay attack, the man-in-the-middle attack, and the desynchronization. However, we find that the protocol is vulnerable to a novel forgery attack presented in the paper. The forgery attack undermines the protocol in the mutual authentication and the resistance against both the man-in-the-middle attack and the desynchronization as claimed. In addition to the security vulnerability, the protocol is also inefficient in implementation, because it makes use of the timestamp and random number simultaneously. Therefore, the protocol is not suitable for the wireless security systems. We hope that our cryptanalysis results are useful to design more robust RFID authentication protocols for the wireless security systems in the future.

The lanthanum-modified lead zirconate titanate transparent ceramics with different Zr/Ti ratio were prepared by the hot pressing sintering method. A single perovskive structure with a dense microsctructure was obtained and the transgranular fracture of PLZT ceramics tended to be more serious As the Zr/Ti ratio increases, the transmittance of PLZT ceramics tended to be higher and the transgranular fracture became more serious. The P-E loops changed froe a square hysteresis loop to a double tending slim hysteresis loop. Besides,the S-E loops changed from a approximate parabolic shape to a butterfly shape. These two loops confirm the transition from normal ferroelectric to anti ferroelectric phase occured with the Zr/Ti ratio increasing.

A rapid analytical method was established for the determination of trace amounts of microcystin (MC-LR) in environmental water samples by using magnetic solid phase extraction (MSPE) coupled with HPLC/UV based on a magnetic bentonite sorbent fabricated by solvothermal synthesis method. Several factors influencing the extraction efficiency of MC-LR, such as sorbent amount, pH condition, sample volume, adsorption and desorption time, and desorption solvent, were investigated and optimized. Under the optimal extraction conditions, the limits of detection and quantification for the method were 0.75 and 1.5 ng L −1 , respectively, which was far below the guideline recommended by the World Health Organisation. The method showed a good linearity ( R 2 = 0.9993) in the concentration ranges of 0.25–250 μg L −1 for MC-LR. The MSPE sorbent was simple in preparation, low cost and magnetizable, and the developed MSPE-HPLC method was suitable for the rapid and sensitive determination of MC-LR in nature water samples.

In recent years, Chinese medicine has played an important role in the prognosis of gastric cancer. Precancerous lesions of gastric carcinoma (PLGC) is a class of gastric cancer which is closely related to the gastric mucosal pathology changes in the role of carcinogenic incentives, and plays key role in the progression of normal gastric mucosal cells into gastric cancerous cells. In current experiment, we explore the relationship between Chinese traditional medicine (Xiao Tan He Wei Decoction) and gastric cancer in the PLGC rat animal models and epithelial-mesenchymal transitioned GES-1 cells which were induced useing 1- Methyl-3-nitro-1-nitrosoguanidine (MNNG). PLGC rat model showed significant deterioration in the gastric mucosa with terrible growth rate in body weight and more atypical hyperplasia in gastric mucosa. MC cells, MNNG induced GES-1 cells which epithelial- mesenchymal-transition (EMT)-related proteins have a great change compare with normal GES-1 cells. The cells had characteristics of malignant cells including proliferation, invasion and metastasis ability. Our research founds that Xiao Tan He Wei Decoction could inhibit cell proliferation and increased apoptosis by increase the level of pro-apoptotic proteins like Bax and caspase-3 and decreased the level of anti-apoptotic protein Bcl-2, block the cells in G0/G1 phase simultaneously. Furthermore, Xiao Tan He Wei Decoction could inhibit nuclear factor kappa-light-chain-enhancer (NF-kB) activity and inhibit its transfer from the cytoplasm to the nucleus. However, when we incubated with NF-κB activator PMA, the effect of Xiao Tan He Wei Decoction was reversed. These results suggested that Xiao Tan He Wei Decoction could be used as a method for the treatment of gastric precancerous lesions, and possibly provide a theoretical basis for the clinical treatment of gastric cancer and gastric precancerous lesions.

In spite of numerous protection schemes, embedded systems are still faced with the danger of being attacked, especially at run time. Some ‘trusted’ programs may be attacked and then result in unintended behaviors, such as jumping to malicious code and leakage of sensitive data. Control flow authentication is one of efficient methods to protect the security of embedded system by ensuring system run along the designed control flow path. In this paper, we propose a new control flow authentication method to further improve the efficiency. A hardware monitor on chip is designed to help authenticate most control flow edges. And the control flow edges in loops are isolated and protected by self-validation software. This software method inserts assembly code upon every basic blocks in a loop to authenticate control flow edges by computing three validation variables. This loop isolation method helps hardware monitor to protect control flow edges which are repeatedly validated in loops to reduce validation times. With this combination, both performance and fault coverage rate have improved compared to traditional methods. To evaluate the performance, we built the system based on ARM v7-A architecture and simulated it using the cycle-accurate simulator GEM5 with SPEC2006 benchmarks.

To evaluate the impact of Jinlongshe Granule (金龙蛇颗粒, JLSG) on quality of life (QOL) of stage IV gastric cancer patients. This randomized, double-blind and placebo-controlled clinical trial included 50 patients with advanced gastric cancer. They were equally randomized into a JLSG group and a placebo group. Patients in both groups received routine Chinese herbal decoctions according to Chinese medicine (CM) treatment based on syndrome differentiation. Patients in JLSG group received additional JLSG, and those in the placebo group received an additional placebo. In the JLSG group, 19 patients who completed the study were used for analysis. In the placebo group, finally the data of 20 patients who completed the study were used for analysis. The treatment course was at least 3 months, and the follow-up duration was at least 6 months in 5 interviews. Repeated measurements of the subscale items and individual items in European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire C30 (EORTC QLQ-C30) obtained at the 5 interviews were compared using different patient groups, changes over time and changes within one group over time independently to observe the tendency of changes in the scores. Using time as the variant, there was signifificant difference in 4 functional scales (physical, role, emotional and social, P 0.05), insomnia (P 0.05) and financial difficulties (P

This paper introduced an optimization model to address dynamic speed control strategies for achieving network-wide speed harmonization. Genetic Algorithm (GA) was applied to search the optimal solution of the proposed model. During the search process, a computational fluid dynamics (CFD) based analytical model and microscopic traffic simulation VISSIM were applied to evaluate the performance of possible solutions. The proposed model can be used to determine the deployment of dynamic speed limits, the displayed speed limit, and the timing to change these speed limits. The proposed model was tested using VISSIM in an urban freeway network of about 12 miles long. Different simulation scenarios with varying AADT from 60,000 to 12,000 were tested. It was found that when properly implemented, dynamic speed control can improve traffic flow conditions, reduce congestion and emission, and enhance network throughput. For example, in the selected urban freeway network with the AADT of 80,000, the proposed dynamic speed control strategy can save 5% average travel time, reduce 9% of the vehicles with high collision risk and about 11% emission.

The objective of this study is to develop a microscopic simulation model to objectively compare operational improvements with capacity expansions. Simulation software VISSIM was used to redesign the existing facilities for the performance evaluation of operational improvement and capacity expansion strategies from delay time, emission and fuel consumption perspective. Two case studies were performed with different test beds to evaluate the effectiveness of performance evaluation model, majorly involving dynamic speed, ramp metering and hard shoulder usage strategies which are discussed in detail to illustrate the changes due to operational improvement and capacity expansion strategies.

A simple and green method has been developed for in situ assembly of magnetic Fe 3 O 4 on the pillared bentonite by a solvothermal reaction. Fe 3 O 4 nanopaticles have a nearly uniform size of about 200 nm, and they create the homogeneous structures distributed on the bentonite surface. The resulting magnetic material (Fe 3 O 4 @Al-B) has a surface area of 110 m 2 /g and a saturation magnetization of 36.18 emu/g. At the same time, Fe 3 O 4 @Al-B has a strong surface affinity toward microcystin-LR (MC-LR) both in Mili-Q water and river water samples. Adsorption of MC-LR on Fe3O4@Al-B increases with pH decrease, with a maximum adsorption at pH 2.1. The equilibrium adsorption data are also analyzed by using the Langmuir and Freundlich models to evaluate the adsorption capacity of Fe3O4@Al-B and a result of 161.29 mg/g is achieved. The pseudo-second-order kinetic model provides the best correlation of the experimental data. Therefore, Fe 3 O 4 @Al-B is an effective technology and has a great potential in removing MC-LR from drinking water resources.

Bluetooth low energy devices are very popular in wireless personal area networks. According to the Bluetooth standard specifications, the low energy secure simple pairing (LESSP) protocol is the process by which the pairing devices negotiate the authenticated secret key. To violate the user privacy, the adversary can perhaps link the runs of the LESSP protocol to the targeted device, which usually relates to the specially appointed user. Hence, we investigate deep into the privacy of the LESSP protocol. Our main contributions are threefold: (1) We demonstrate that the LESSP protocol suffers from privacy vulnerability. That is, an adversary without any secret key is able to identify the targeted device by the LESSP protocol. (2) An improvement is therefore proposed to repair the privacy vulnerability in the LESSP protocol. (3) We develop a formal privacy model to evaluate the privacy vulnerabilities in the LESSP protocol and its improved versions. We further prove that our improvement on the LESSP protocol is private under the privacy model. In addition, the performance evaluation shows that our improvement is as efficient as the LESSP protocol. Our research results are beneficial to the privacy enhancement of Bluetooth systems in wireless personal area networks.

Very recently, Khan, Kim, and Alghathbar [6] proposed a dynamic ID-based remote user authentication scheme and claimed that their scheme can provide user anonymity. However, in this article, the authors demonstrate that either a malicious user or an adversary with a valid smart card can trace any user by eavesdropping on his normal authentication session over the public channel. Therefore, Khan et al.'s scheme fails to provide the privacy service as claimed. Hence, the authors present an improved scheme to overcome its flaw and examine the privacy of the improved scheme by using the smart card-based privacy model. In addition, the security and efficiency of the improved scheme are scrutinized. The conclusive result is that the design of the improved scheme is reasonable in not only both privacy and security aspects but also the performance aspect.

Aurivillius phase ferroelectrics Ba(Bi1−xLax)4Ti4O15(x=0-0.05) (BBiLxT) was synthesized by a modified high-temperature solid-phase route.The structure, the dielectric, the ferroelectric and the aging properties were investigated systematically. With the La3+doping, the room temperature relative permittivity of the samples is increased, and dielectric loss is decreased. For the BBiLxT phase, only a weak variation with respect to the F2mm space group can be suggested from single crystal X-ray diffraction. The microstructure confirms the samples have a well-proportioned grain size and a higher density. The substitution also results in a marked improvement in the remnant polarization. The doping of La3+in BBiLxT ceramics increased the room temperature relative permittivity aging properties.

BaBi2Nb2O9/PVDF (polyvinylidene fluoride) composite ultrafiltration (UF)membranes were prepared by alloying BaBi2Nb2O9 (BBN) particles uniformly in the PVDF solution (15% polymer weight) and used a phase-inversion method. This paper studied the effect of the concentration of BBN from 0% to 5% in 0.2Mpa on pure water flux and rejection rate to Bovine serum albumin (BSA). The cross-sectional structures of composite membranes were observed by scanning electron microscopy (SEM). Moreover, XRD results revealed the crystal structure of PVDF. The experimental results showed that the BBN/PVDF composite ultrafiltration membranes were superior in separation performances than the pure PVDF membranes due to the addition of BBN.

Currently, Yttria-stabilized zirconia solid state electrolyte are widely used in various fields . The basic performance of Yttria-stabilized zirconia (5YSZ) prepared by different synthesis methods and sintering temperatures are studied in this paper ,their phase compositions and microstructure are studied with XRD and SEM. The ionic conductivity of 5YSZ sintered at different temperature are studied with A.C. impedance spectroscopy measurement.

In 2009, Wu proposed a fast modular exponentiation algorithm and claimed that the proposed algorithm on average saved about 38.9% and 26.68% of single-precision multiplications as compared to Dusse-Kaliski's Montgomery algorithm and Ha-Moon's Montgomery algorithm, respectively. However, in this comment, we demonstrate that Wu's algorithm on average reduces the number of single-precision multiplications by at most 22.43% and 6.91%, when respectively compared with Dusse-Kaliski's version and Ha-Moon's version. That is, the computational efficiency of Wu's algorithm is obviously overestimated.

Recently, pairing based cryptography has drawn a lot of attention since it is the key technology to construct identity based encryption schemes. Major operations of pairing are elliptic curve computations defined upon finite field arithmetic. Hardware implementation of large prime field operation is critical to improve the practicality of pairing based cryptography. In this paper, we present a parallel processing architecture of cryptoprocessor for optimal ate pairings over BN-curves in prime field. The proposed design contains two arithmetic processing engines to complete prime field operations in parallel. Each engine is designed by the unified Fp arithmetic unit to save hardware resources. This architecture can also be used to implement RSA and ECC cryptography schemes in parallel to satisfy industry demand. The design is implemented on a Virtex-5 FPGA device. The result shows our design consumes 10592 Slices and computes optimal-ate pairing within 283,111 clock cycles, achieving a better balance between speed and area than other designs.

A basic but expensive operation in implementations of several famous public-key cryptosystems is the computation of the multi-exponentiation in a certain finite multiplication group. In 2007, Yang et al. presented an interesting asynchronous multi-exponentiation algorithm called the SU"t method, which uses the binary representations for the exponents. In this note, we analyze the computational efficiency of the SU"t method by modeling the scanning process as a Markov chain. It shows that their computational efficiency result is incorrect. Moreover, we make a performance comparison among the published techniques and show that the performance of a modified sliding window method is better than that of the SU"t method, when there are 4 or more additional registers. We hope that our research will be convenient to the development of the cryptographic devices.

RFID (Radio Frequency Identification) tags are small, wireless electronic devices that help identify objects and people. Privacy protection and integrity assurance become rather crucial in the RFID systems, because these RFID tags may have a wide transmission range, making them subject to unauthorized scanning by malicious readers and various other attacks. Hence, Ha et al. proposed an RFID protocol and proved that their protocol can provide the forward privacy service. However, in this paper, it is shown that an attacker can track a target tag by observing unsuccessful previous session of the tag. That is, Ha et al.'s RFID protocol fails to provide the forward privacy protection as claimed. Therefore, to overcome the privacy weaknesses of Ha et al.'s RFID protocol, an RFID protocol based on the cryptographic hash functions is proposed. Moreover, the proposed RFID protocol is evaluated according to both the privacy attribute and the implementation performance.

A parallel architecture for efficient hardware implementation of Rivest Shamir Adleman (RSA) cryptography is proposed. Residue number system (RNS) is introduced to realize high parallelism, thus all the elements under the same base are independent of each other and can be computed in parallel. Moreover, a simple and fast base transformation is used to achieve RNS Montgomery modular multiplication algorithm, which facilitates hardware implementation. Based on transport triggered architecture (TTA), the proposed architecture is designed to evaluate the performance and feasibility of the algorithm. With these optimizations, a decryption rate of 106 kbps can be achieved for 1 024-b RSA at the frequency of 100 MHz.