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Background: Access to healthcare services for the population with long COVID is a challenge, as healthcare systems have been tasked with responding effectively to the extensive clinical heterogeneity of this disease., Objective: To analyze the factors associated with access to health services among people with long COVID in the Brazilian Amazon., Methods: This is a cross-sectional study using a quantitative method, conducted through an online survey between May 2023 and January 2024. The study included participants aged 18 years or older, residing in the northern region of Brazil, with a confirmed diagnosis of COVID-19 and who experienced long COVID. Participants completed an adapted version of the questionnaire on the Research Electronic Data Capture platform. Data were analyzed by multiple logistic regression., Results: A total of 364 people with long COVID participated in the study, of which only 167 (45.88%) had access to healthcare to treat the symptoms of this clinical condition. In the final multiple logistic regression model, only factors related to the need for services were associated with healthcare access. Participants with symptoms of dermatological alterations (AOR = 2.57; p  = 0.01), a pre-COVID-19 diagnosis of chronic disease (AOR = 5.62; p  = 0.04), those who treated their most severe COVID-19 infection with the assistance of a healthcare professional (AOR = 4.97; p  = 0.01), and those who used antibiotics during their most severe COVID-19 infection (AOR = 3.24; p  = 0.01) were more likely to access healthcare services for treating long COVID., Conclusion: Factors related to the need for services were the only ones associated in this population. It is important to know these aspects to identify the most affected populations and propose measures., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Miranda, Costa, da Paixão, Martins, Polaro, Cunha, Botelho, Pedroso, Silva, Reis and Ferreira.)

Acquired immune deficiency syndrome (AIDS) is an infectious disease caused by the types 1 and 2 human immunodeficiency virus (HIV-1 and HIV-2). Clinical outcomes in patients are highly varied and delineated by complex interactions between virus, host, and environment, such as with help of co-receptors, for example, the C-C chemokine receptor 5 (CCR5). This work aimed to describe the scientific evidence relating the influence of CCR5 polymorphisms in association studies for HIV-1 disease susceptibility, severity, and transmissibility. This is a systematic review of the literature on single nucleotide polymorphisms (SNPs) and the deletion [Insertion and Deletion (Indel)] Δ32 of CCR5 . The search for articles was based on the ScienceDirect, PubMed, and Coordination for the Improvement of Higher Education Personnel (CAPES) databases for the period between 2001 and 2021. The final sample consisted of 32 articles. † SNP rs1799987 is one of the genetic polymorphisms most associated with the criteria of susceptibility and severity of HIV-1, having distinct consequences in genotypic, allelic, and clinical analysis in the variability of investigated populations. As for the transmission character of the disease, the G mutant allele of rs1799987 corresponds to the highest positive association. ‡ Furthermore, the results on Indel Δ32 corroborate the absence and rarity of this variant in some populations. Finally, mitigating the severity of cases, SNPs rs1799988 and rs1800023 obtained significant attribution in individuals in the studied populations. It is shown that the reported polymorphisms express significant influences for the evaluation of diagnostic, therapeutic, and prophylactic measures for HIV-1 having fundamental particularities in the molecular, genetic, and transcriptional aspects of CCR5 .