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Your search keyword '"Coote, Carolyn"' showing total 8 results
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7. HIV-1 Transcription but Not Intact Provirus Levels are Associated With Systemic Inflammation.

Author

Olson, Alex, Coote, Carolyn, Snyder-Cappione, Jennifer E, Lin, Nina, and Sagar, Manish

Subjects
*MONONUCLEAR leukocytes, *HIV, *HIV infections, *VIRAL physiology, *VIRUSES, *INFLAMMATION, *RNA, *FIBRIN fibrinogen degradation products
Abstract

Individuals infected with human immunodeficiency virus (HIV) 1 have increased inflammation, which has been associated with age-associated diseases. Plasma markers, cell-associated virus levels, and ability to stimulate RNA transcription in latently infected cell lines was examined in younger and older HIV-1-infected individuals with suppressed virus. Cell-associated RNA, but not intact provirus level, had positive correlation with plasma D-dimer levels. Compared with the younger group, the older group had higher D-dimer levels and a trend toward more cell-associated RNA but similar levels of intact proviruses. Even though all measured inflammatory markers were relatively higher in the older group, this greater inflammation did not induce more HIV-1 transcription in latently infected cell lines. Inflammation and HIV-1 RNA expression increase with age despite similar levels of intact infectious HIV DNA. While plasma inflammation is correlated with HIV-1 RNA expression in peripheral blood mononuclear cells, it does not induce HIV-1 transcription in latently infected cell lines. [ABSTRACT FROM AUTHOR]

Published
2021
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