1,354 results on '"Clarke, F."'
Search Results
2. Optical integral field spectroscopy of intermediate redshift infrared bright galaxies
- Author
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Pereira-Santaella, M., Rigopoulou, D., Magdis, G. E., Thatte, N., Alonso-Herrero, A., Clarke, F., Farrah, D., García-Burillo, S., Hogan, L., Morris, S., Rodrigues, M., Huang, J. -S., and Tecza, M.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The extreme infrared (IR) luminosity of local luminous and ultra-luminous IR galaxies (U/LIRGs; 11 < log LIR /Lsun < 12 and log LIR /Lsun > 12, respectively) is mainly powered by star-formation processes triggered by mergers or interactions. While U/LIRGs are rare locally, at z > 1, they become more common, they dominate the star-formation rate (SFR) density, and a fraction of them are found to be normal disk galaxies. Therefore, there must be an evolution of the mechanism triggering these intense starbursts with redshift. To investigate this evolution, we present new optical SWIFT integral field spectroscopic H{\alpha}+[NII] observations of a sample of 9 intermediate-z (0.2 < z < 0.4) U/LIRG systems selected from Herschel 250{\mu}m observations. The main results are the following: (a) the ratios between the velocity dispersion and the rotation curve amplitude indicate that 10-25% (1-2 out of 8) might be compatible with being isolated disks while the remaining objects are interacting/merging systems; (b) the ratio between un-obscured and obscured SFR traced by H{\alpha} and LIR, respectively, is similar in both local and these intermediate-z U/LIRGs; and (c) the ratio between 250{\mu}m and the total IR luminosities of these intermediate-z U/LIRGs is higher than that of local U/LIRGs with the same LIR . This indicates a reduced dust temperature in these intermediate-z U/LIRGs. This, together with their already measured enhanced molecular gas content, suggests that the interstellar medium conditions are different in our sample of intermediate-z galaxies when compared to local U/LIRGs., Comment: Accepted for publication in MNRAS
- Published
- 2019
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3. The adaptive optics modes for HARMONI: from Classical to Laser Assisted Tomographic AO
- Author
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Neichel, B., Fusco, T., Sauvage, J. -F., Correia, C., Dohlen, K., El-Hadi, K., Blanco, L., Schwartz, N., Clarke, F., Thatte, N., Tecza, M., Paufique, J., Vernet, J., Louarn, M. Le, Hammersley, P., Gach, J. -L., Pascal, S., Vola, P., Petit, C., Conan, J. -M., Carlotti, A., Verinaud, C., Schnetler, H., Bryson, I., Morris, T., Myers, R., Hugot, E., and Gallie, A.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
HARMONI is a visible and NIR integral field spectrograph, providing the E-ELT's core spectroscopic capability at first light. HARMONI will work at the diffraction limit of the E-ELT, thanks to a Classical and a Laser Tomographic AO system. In this paper, we present the system choices that have been made for these SCAO and LTAO modules. In particular, we describe the strategy developed for the different Wave-Front Sensors: pyramid for SCAO, the LGSWFS concept, the NGSWFS path, and the truth sensor capabilities. We present first potential implementations. And we asses the first system performance., Comment: SPIE proceeding, 2016
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- 2018
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4. CASTAway: An Asteroid Main Belt Tour and Survey
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Bowles, N. E., Snodgrass, C., Gibbings, A, Sanchez, J. P., Arnold, J. A., Eccleston, P., Andert, T., Probst, A., Naletto, G., Vandaele, A. C., de Leon, J., Nathues, A., Thomas, I. R., Thomas, N., Jorda, L., Da Deppo, V., Haack, H., Green, S. F., Carry, B., Hanna, K. L. Donaldson, Jorgensen, J. Leif, Kereszturi, A., DeMeo, F. E., Patel, M. R., Davies, J. K., Clarke, F., Kinch, K., Guilbert-Lepoutre, A., Agarwal, J., Rivkin, A. S., Pravec, P., Fornasier, S., Granvik, M., Jones, R. H., Murdoch, N., Joy, K. H., Pascale, E., Tecza, M., Barnes, J. M., Licandro, J., Greenhagen, B. T., Calcutt, S. B., Marriner, C. M., Warren, T., and Tosh, I.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
CASTAway is a mission concept to explore our Solar System's main asteroid belt. Asteroids and comets provide a window into the formation and evolution of our Solar System and the composition of these objects can be inferred from space-based remote sensing using spectroscopic techniques. Variations in composition across the asteroid populations provide a tracer for the dynamical evolution of the Solar System. The mission combines a long-range (point source) telescopic survey of over 10,000 objects, targeted close encounters with 10 to 20 asteroids and serendipitous searches to constrain the distribution of smaller (e.g. 10 m) size objects into a single concept. With a carefully targeted trajectory that loops through the asteroid belt, CASTAway would provide a comprehensive survey of the main belt at multiple scales. The scientific payload comprises a 50 cm diameter telescope that includes an integrated low-resolution (R = 30 to 100) spectrometer and visible context imager, a thermal (e.g. 6 to 16 microns) imager for use during the flybys, and modified star tracker cameras to detect small (approx. 10 m) asteroids. The CASTAway spacecraft and payload have high levels of technology readiness and are designed to fit within the programmatic and cost caps for a European Space Agency medium class mission, whilst delivering a significant increase in knowledge of our Solar System., Comment: 40 pages, accepted by Advances in Space Research October 2017
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- 2017
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5. Simulated stellar kinematics studies of high-redshift galaxies with the HARMONI Integral Field Spectrograph
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Kendrew, S., Zieleniewski, S., Houghton, R. C. W., Thatte, N., Devriendt, J., Tecza, M., Clarke, F., O'Brien, K., and Häussler, B.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present a study into the capabilities of integrated and spatially resolved integral field spectroscopy of galaxies at z=2-4 with the future HARMONI spectrograph for the European Extremely Large Telescope (E-ELT) using the simulation pipeline, HSIM. We focus particularly on the instrument's capabilities in stellar absorption line integral field spectroscopy, which will allow us to study the stellar kinematics and stellar population characteristics. Such measurements for star-forming and passive galaxies around the peak star formation era will provide a critical insight into the star formation, quenching and mass assembly history of high-z, and thus present-day galaxies. First, we perform a signal-to-noise study for passive galaxies at a range of stellar masses for z=2-4, assuming different light profiles; for this population we estimate integrated stellar absorption line spectroscopy with HARMONI will be limited to galaxies with M_star > 10^10.7 solar masses. Second, we use HSIM to perform a mock observation of a typical star-forming 10^10 solar mass galaxy at z=3 generated from the high-resolution cosmological simulation NutFB. We demonstrate that the input stellar kinematics of the simulated galaxy can be accurately recovered from the integrated spectrum in a 15-hour observation, using common analysis tools. Whilst spatially resolved spectroscopy is likely to remain out of reach for this particular galaxy, we estimate HARMONI's performance limits in this regime from our findings. This study demonstrates how instrument simulators such as HSIM can be used to quantify instrument performance and study observational biases on kinematics retrieval; and shows the potential of making observational predictions from cosmological simulation output data., Comment: accepted for publication in MNRAS
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- 2016
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6. HSIM: a simulation pipeline for the HARMONI integral field spectrograph on the European ELT
- Author
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Zieleniewski, S., Thatte, N., Kendrew, S., Houghton, R. C. W., Swinbank, A. M., Tecza, M., Clarke, F., and Fusco, T.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present HSIM: a dedicated pipeline for simulating observations with the HARMONI integral field spectrograph on the European Extremely Large Telescope. HSIM takes high spectral and spatial resolution input data-cubes, encoding physical descriptions of astrophysical sources, and generates mock observed data-cubes. The simulations incorporate detailed models of the sky, telescope and instrument to produce realistic mock data. Further, we employ a new method of incorporating the strongly wavelength dependent adaptive optics point spread functions. HSIM provides a step beyond traditional exposure time calculators and allows us to both predict the feasibility of a given observing programme with HARMONI, as well as perform instrument design trade-offs. In this paper we concentrate on quantitative measures of the feasibility of planned observations. We give a detailed description of HSIM and present two studies: estimates of point source sensitivities along with simulations of star-forming emission-line galaxies at $z\sim 2-3$. We show that HARMONI will provide exquisite resolved spectroscopy of these objects on sub-kpc scales, probing and deriving properties of individual star-forming regions., Comment: 13 pages, 11 figures, 3 tables, accepted for publication in MNRAS
- Published
- 2015
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7. Fast and Slow Rotators in the Densest Environments: a SWIFT IFS study of the Coma Cluster
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Houghton, R. C. W., Davies, Roger L., D'Eugenio, F., Scott, N., Thatte, N., Clarke, F., Tecza, M., Salter, G. S., Fogarty, L. M. R., and Goodsall, T.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present integral-field spectroscopy of 27 galaxies in the Coma cluster observed with the Oxford SWIFT spectrograph, exploring the kinematic morphology-density relationship in a cluster environment richer and denser than any in the ATLAS3D survey. Our new data enables comparison of the kinematic morphology relation in three very different clusters (Virgo, Coma and Abell 1689) as well as to the field/group environment. The Coma sample was selected to match the parent luminosity and ellipticity distributions of the early-type population within a radius 15' (0.43 Mpc) of the cluster centre, and is limited to r' = 16 mag (equivalent to M_K = -21.5 mag), sampling one third of that population. From analysis of the lambda-ellipticity diagram, we find 15+-6% of early-type galaxies are slow rotators; this is identical to the fraction found in the field and the average fraction in the Virgo cluster, based on the ATLAS3D data. It is also identical to the average fraction found recently in Abell 1689 by D'Eugenio et al.. Thus it appears that the average slow rotator fraction of early type galaxies remains remarkably constant across many different environments, spanning five orders of magnitude in galaxy number density. However, within each cluster the slow rotators are generally found in regions of higher projected density, possibly as a result of mass segregation by dynamical friction. These results provide firm constraints on the mechanisms that produce early-type galaxies: they must maintain a fixed ratio between the number of fast rotators and slow rotators while also allowing the total early-type fraction to increase in clusters relative to the field. A complete survey of Coma, sampling hundreds rather than tens of galaxies, could probe a more representative volume of Coma and provide significantly stronger constraints, particularly on how the slow rotator fraction varies at larger radii., Comment: Accepted for publication in MNRAS
- Published
- 2013
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8. Black hole mass and Eddington ratio distribution functions of X-ray selected broad-line AGNs at z~1.4 in the Subaru XMM-Newton Deep Field
- Author
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Nobuta, K., Akiyama, M., Ueda, Y., Watson, M. G., Silverman, J., Hiroi, K., Ohta, K., Iwamuro, F., Yabe, K., Tamura, N., Moritani, Y., Sumiyoshi, M., Kimura, M., Maihara, T., Dalton, G., Lewis, I., Bonfield, D., Lee, H., Lake, E. Curtis, Macaulay, E., Clarke, F., Sekiguchi, K., Simpson, C., Croom, S., Ouchi, M., Hanami, H., and Yamada, T.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
In order to investigate the growth of super-massive black holes (SMBHs), we construct the black hole mass function (BHMF) and Eddington ratio distribution function (ERDF) of X-ray-selected broad-line AGNs at z~1.4 in the Subaru XMM-Newton Deep Survey field. In this redshift range, a significant part of the accretion growth of SMBHs is thought to be taking place. Black hole masses of X-ray-selected broad-line AGNs are estimated using the width of the broad MgII line and the 3000A monochromatic luminosity. We supplement the MgII FWHM values with the Ha FWHM obtained from our NIR spectroscopic survey. Using the black hole masses of broad-line AGNs at redshifts between 1.18 and 1.68, the binned broad-line AGN BHMF and ERDF are calculated using the Vmax method. To properly account for selection effects that impact the binned estimates, we derive the corrected broad-line AGN BHMF and ERDF by applying the Maximum Likelihood method, assuming that the ERDF is constant regardless of the black hole mass. We do not correct for the non-negligible uncertainties in virial BH mass estimates. If we compare the corrected broad-line AGN BHMF with that in the local Universe, the corrected BHMF at z~1.4 has a higher number density above 10^8 Msolar but a lower number density below that mass range. The evolution may be indicative of a down-sizing trend of accretion activity among the SMBH population. The evolution of broad-line AGN ERDF from z=1.4 to 0 indicates that the fraction of broad-line AGNs with accretion rate close to the Eddington-limit is higher at higher redshifts., Comment: 23 pages with 18 figures. Accepted for publication in ApJ
- Published
- 2012
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9. Oxford SWIFT IFS and multi-wavelength observations of the Eagle galaxy at z=0.77
- Author
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Kassin, Susan A., Fogarty, L., Goodsall, T., Clarke, F. J., Houghton, R. W. C., Salter, G., Thatte, N., Tecza, M., Davies, Roger L., Weiner, Benjamin J., Willmer, C. N. A., Salim, Samir, Cooper, Michael C., Newman, Jeffrey A., Bundy, Kevin, Conselice, C. J., Koekemoer, A. M., Lin, Lihwai, Moustakas, Leonidas A., and Wang, Tao
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The `Eagle' galaxy at a redshift of 0.77 is studied with the Oxford Short Wavelength Integral Field Spectrograph (SWIFT) and multi-wavelength data from the All-wavelength Extended Groth strip International Survey (AEGIS). It was chosen from AEGIS because of the bright and extended emission in its slit spectrum. Three dimensional kinematic maps of the Eagle reveal a gradient in velocity dispersion which spans 35-75 +/- 10 km/s and a rotation velocity of 25 +/- 5 km/s uncorrected for inclination. Hubble Space Telescope images suggest it is close to face-on. In comparison with galaxies from AEGIS at similar redshifts, the Eagle is extremely bright and blue in the rest-frame optical, highly star-forming, dominated by unobscured star-formation, and has a low metallicity for its size. This is consistent with its selection. The Eagle is likely undergoing a major merger and is caught in the early stage of a star-burst when it has not yet experienced metal enrichment or formed the mass of dust typically found in star-forming galaxies., Comment: accepted for publication in MNRAS
- Published
- 2011
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10. Latest Results from the DODO Survey: Imaging Planets around White Dwarfs
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Hogan, E., Burleigh, M. R., and Clarke, F. J.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The aim of the Degenerate Objects around Degenerate Objects (DODO) survey is to search for very low mass brown dwarfs and extrasolar planets in wide orbits around white dwarfs via direct imaging. The direct detection of such companions would allow the spectroscopic investigation of objects with temperatures lower (< 500 K) than the coolest brown dwarfs currently observed. The discovery of planets around white dwarfs would prove that such objects can survive the final stages of stellar evolution and place constraints on the frequency of planetary systems around their progenitors (with masses between 1.5 - 8 M*, i.e., early B to mid-F). An increasing number of planetary mass companions have been directly imaged in wide orbits around young main sequence stars. For example, the planets around HR 8799 and 1RXS J160929.1 - 210524 are in wide orbits of 24 - 68 AU and 330 AU, respectively. The DODO survey has the ability to directly image planets in post-main sequence analogues of these systems. These proceedings present the latest results of our multi-epoch J band common proper motion survey of nearby white dwarfs., Comment: Part of PlanetsbeyondMS/2010 proceedings http://arxiv.org/html/1011.6606
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- 2011
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11. The DODO Survey II: A Gemini Direct Imaging Search for Substellar and Planetary Mass Companions around Nearby Equatorial and Northern Hemisphere White Dwarfs
- Author
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Hogan, E., Burleigh, M. R., and Clarke, F. J.
- Subjects
Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The aim of the Degenerate Objects around Degenerate Objects (DODO) survey is to search for very low mass brown dwarfs and extrasolar planets in wide orbits around white dwarfs via direct imaging. The direct detection of such companions would allow the spectroscopic investigation of objects with temperatures much lower (< 500 K) than the coolest brown dwarfs currently observed. These ultra-low mass substellar objects would have spectral types > T8.5 and so could belong to the proposed Y dwarf spectral sequence. The detection of a planet around a white dwarf would prove that such objects can survive the final stages of stellar evolution and place constraints on the frequency of planetary systems around their progenitors (with masses between 1.5 - 8 solar masses, i.e., early B to mid F). This paper presents the results of a multi-epoch J band common proper motion survey of 23 nearby equatorial and northern hemisphere white dwarfs. We rule out the presence of any common proper motion companions, with limiting masses determined from the completeness limit of each observation, to 18 white dwarfs. For the remaining five targets, the motion of the white dwarf is not sufficiently separated from the non-moving background objects in each field. These targets require additional observations to conclusively rule out the presence of any common proper motion companions. From our completeness limits, we tentatively suggest that < 5% of white dwarfs have substellar companions with effective temperatures > 500 K between projected physical separations of 60 - 200 AU., Comment: 24 pages, 34 figures, 5 tables. Accepted for publication in MNRAS
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- 2009
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12. Fifteen new T dwarfs discovered in the UKIDSS Large Area Survey
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Pinfield, D. J., Burningham, B., Tamura, M., Leggett, S. K., Lodieu, N., Lucas, P. W., Mortlock, D. J., Warren, S. J., Homeier, D., Ishi, M., Deacon, N. R., McMahon, R. G., Hewett, P. C., Osorio, M. R. Zapatero, Martin, E. L., Jones, H. R. A., Venemans, B. P., Day-Jones, A., Dobbie, P. D., Folkes, S. L., Dye, S., Allard, F., Baraffe, I., Navascues, D. Barrado y, Casewell, S. L., Chiu, K., Chabrier, G., Clarke, F., Hodgkin, S. T., Magazzu, A., McCaughrean, M. J., Moraux, E., Nakajima, T., Pavlenko, Y., and Tinney, C. G.
- Subjects
Astrophysics - Abstract
We present the discovery of fifteen new T2.5-T7.5 dwarfs (with estimated distances between ~24-93pc, identified in the first three main data releases of the UKIRT Infrared Deep Sky Survey. This brings the total number of T dwarfs discovered in the Large Area Survey (to date) to 28. These discoveries are confirmed by near infrared spectroscopy, from which we derive spectral types on the unified scheme of Burgasser et al. (2006). Seven of the new T dwarfs have spectral types of T2.5-T4.5, five have spectral types of T5-T5.5, one is a T6.5p, and two are T7-7.5. We assess spectral morphology and colours to identify T dwarfs in our sample that may have non-typical physical properties (by comparison to solar neighbourhood populations). The colours of the full sample of LAS T dwarfs show a possible trend to bluer Y-J with decreasing effective temperature beyond T8. By accounting for the main sources of incompleteness (selection, follow-up and spatial) as well as the effects of unresolved binarity and Malmquist bias, we estimate that there are 17+-4 >=T4 dwarfs in the J<=19 volume of the LAS second data release. Comparing this to theoretical predictions is most consistent with a sub-stellar mass function exponent alpha between -1.0 and 0. This is consistent with the latest 2MASS/SDSS constraint (which is based on lower number statistics), and is significantly lower than the alpha~1.0 suggested by L dwarf field populations, possibly a result of the lower mass range probed by the T dwarf class., Comment: 21 pages, 7 figures, submitted to MNRAS
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- 2008
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13. The 'DODO' survey I: limits on ultra-cool substellar and planetary-mass companions to van Maanen's star (vMa 2)
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Burleigh, M. R., Clarke, F. J., Hogan, E., Brinkworth, C. S., Bergeron, P., Dufour, P., Dobbie, P. D., Levan, A. J., Hodgkin, S. T., Hoard, D. W., and Wachter, S.
- Subjects
Astrophysics - Abstract
We report limits in the planetary-mass regime for companions around the nearest single white dwarf to the Sun, van Maanen's star (vMa 2), from deep J-band imaging with Gemini North and Spitzer IRAC mid-IR photometry. We find no resolved common proper motion companions to vMa 2 at separations from 3" - 45", at a limiting magnitude of J~23. Assuming a total age for the system of 4.1 +/-1 Gyr, and utilising the latest evolutionary models for substellar objects, this limit is equivalent to companion masses >7 +/-1 Mjup (T~300K). Taking into account the likely orbital evolution of very low mass companions in the post-main sequence phase, these J-band observations effectively survey orbits around the white dwarf progenitor from 3 - 50AU. There is no flux excess detected in any of the complimentary Spitzer IRAC mid-IR filters. We fit a DZ white dwarf model atmosphere to the optical BVRI, 2MASS JHK and IRAC photometry. The best solution gives T=6030 +/- 240K, log g=8.10 +/-0.04 and, hence, M= 0.633 +/-0.022Msun. We then place a 3sigma upper limit of 10 +/-2 Mjup on the mass of any unresolved companion in the 4.5 micron band., Comment: Accepted for publication in MNRAS Letters
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- 2008
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14. Two T dwarfs from the UKIDSS Early Data Release
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Kendall, T. R., Tamura, M., Tinney, C. G., Martin, E. L., Ishii, M., Pinfield, D. J., Lucas, P. W., Jones, H. R. A., Leggett, S. K., Dye, S., Hewett, P. C., Allard, F., Baraffe, I., Navascues, D. Barrado y, Carraro, G., Casewell, S. L., Chabrier, G., Chappelle, R. J., Clarke, F., Day-Jones, A., Deacon, N., Dobbie, P. D., Folkes, S., Hambly, N. C., Hodgkin, S. T., Nakajima, T., Jameson, R. F., Lodieu, N., Magazzu, A., McCaughrean, M. J., Pavlenko, Y. V., Tadashi, N., and Osorio, M. R. Zapatero
- Subjects
Astrophysics - Abstract
We report on the first ultracool dwarf discoveries from the UKIRT Infrared Deep Sky Survey (UKIDSS) Large Area Survey Early Data Release (LAS EDR), in particular the discovery of T dwarfs which are fainter and more distant than those found using the 2MASS and SDSS surveys. We aim to show that our methodologies for searching the ~27 sq degs of the LAS EDR are successful for finding both L and T dwarfs $via$ cross-correlation with the Sloan Digital Sky Survey (SDSS) DR4 release. While the area searched so far is small, the numbers of objects found shows great promise for near-future releases of the LAS and great potential for finding large numbers of such dwarfs. Ultracool dwarfs are selected by combinations of their YJH(K) UKIDSS colours and SDSS DR4 z-J and i-z colours, or, lower limits on these red optical/infrared colours in the case of DR4 dropouts. After passing visual inspection tests, candidates have been followed up by methane imaging and spectroscopy at 4m and 8m-class facilities. Our main result is the discovery following CH4 imaging and spectroscopy of a T4.5 dwarf, ULASJ 1452+0655, lying ~80pc distant. A further T dwarf candidate, ULASJ 1301+0023, has very similar CH4 colours but has not yet been confirmed spectroscopically. We also report on the identification of a brighter L0 dwarf, and on the selection of a list of LAS objects designed to probe for T-like dwarfs to the survey J-band limit. Our findings indicate that the combination of the UKIDSS LAS and SDSS surveys provide an excellent tool for identifying L and T dwarfs down to much fainter limits than previously possible. Our discovery of one confirmed and one probable T dwarf in the EDR is consistent with expectations from the previously measured T dwarf density on the sky., Comment: 7 pages, 5 figures, A&A in press
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- 2007
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15. CASTAway: An asteroid main belt tour and survey
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Bowles, N.E., Snodgrass, C., Gibbings, A., Sanchez, J.P., Arnold, J.A., Eccleston, P., Andert, T., Probst, A., Naletto, G., Vandaele, A.C., de Leon, J., Nathues, A., Thomas, I.R., Thomas, N., Jorda, L., Da Deppo, V., Haack, H., Green, S.F., Carry, B., Donaldson Hanna, K.L., Leif Jorgensen, J., Kereszturi, A., DeMeo, F.E., Patel, M.R., Davies, J.K., Clarke, F., Kinch, K., Guilbert-Lepoutre, A., Agarwal, J., Rivkin, A.S., Pravec, P., Fornasier, S., Granvik, M., Jones, R.H., Murdoch, N., Joy, K.H., Pascale, E., Tecza, M., Barnes, J.M., Licandro, J., Greenhagen, B.T., Calcutt, S.B., Marriner, C.M., Warren, T., and Tosh, I.
- Published
- 2018
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16. Time resolved spectroscopy of the variable brown dwarf Kelu-1
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Clarke, F. J., Tinney, C. G., and Hodgkin, S. T.
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Astrophysics - Abstract
We report the results of observations designed to investigate the spectroscopic signatures of dust clouds on the L2 brown dwarf Kelu-1. Time resolved medium resolution spectra show no significant evidence of variability in the dust sensitive TiO, CrH and FeH bandheads on the timescale of 1--24 hours. We do however report periodic variability in the psuedo-equivelent width of H-alpha consistent with the 1.8 hour rotation period previously reported for this object Clarke, Tinney & Tolley (2002). Near-contemporaneous I-band photometry shows evidence for non-periodic variability at the level of 2%., Comment: 9 pages, 12 figures. MNRAS in press
- Published
- 2003
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17. A mini-survey for variability in early L dwarfs
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Clarke, F. J., Oppenheimer, B. R., and Tinney, C. G.
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Astrophysics - Abstract
We report differential I-band photometry of four early L-dwarfs obtained to study variability. We detect variability on the timescale of hours in two objects, 2M0746425+200032 (at a level of 0.007 mag -- 6.5 sigma) and 2M1108307+683017 (0.012 mag -- 5 sigma). We also place upper limits of 0.02 mag (1 sigma) on the variability of two others., Comment: 5 pages. MNRAS, in press
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- 2002
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18. Imaging planets around nearby white dwarfs
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Burleigh, M. R., Clarke, F. J., and Hodgkin, S. T.
- Subjects
Astrophysics - Abstract
We suggest that Jovian planets will survive the late stages of stellar evolution, and that white dwarfs will retain planetary systems in wide orbits (>5AU). Utilising evolutionary models for Jovian planets, we show that infra-red imaging with 8m class telescopes of suitable nearby white dwarfs should allow us to resolve and detect companions >3Mjup. Detection of massive planetary companions to nearby white dwarfs would prove that such objects can survive the final stages of stellar evolution, place constraints on the frequency of main sequence stars with planetary systems dynamically similar to our own and allow direct spectroscopic investigation of their composition and structure., Comment: Accepted for publication in MNRAS pink pages
- Published
- 2002
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19. Periodic photometric variability of the brown dwarf Kelu-1
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Clarke, F. J., Tinney, C. G., and Covey, K. R.
- Subjects
Astrophysics - Abstract
We have detected a strong periodicity of 1.80+/-0.05 hours in photometric observations of the brown dwarf Kelu-1. The peak-to-peak amplitude of the variation is ~1.1% (11.9+/-0.8 mmag) in a 41nm wide filter centred on 857nm and including the dust/temperature sensitive TiO & CrH bands. We have identified two plausible causes of variability: surface features rotating into- and out-of-view and so modulating the light curve at the rotation period; or, elliposidal variability caused by an orbiting companion. In the first scenario, we combine the observed vsin(i) of Kelu-1 and standard model radius to determine that the axis of rotation is inclined at 65+/-12 degrees to the line of sight., Comment: 7 pages, 9 figures. Accepted for publication in MNRAS
- Published
- 2002
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20. A Comparison of Logging Systems and Bat Diversity in the Neotropics
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Clarke, F. M., Pio, D. V., and Racey, P. A.
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- 2005
21. Life after Logging: Post-Logging Recovery of a Neotropical Bat Community
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Clarke, F. M., Rostant, L. V., and Racey, P. A.
- Published
- 2005
22. O-141 Combination of gefitinib and methotrexate to treat tubal ectopic pregnancy (GEM3): a multicentre, randomised, double-blind, placebo-controlled trial
- Author
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Horne, A, primary, Tong, S, additional, Moakes, C, additional, Middleton, L, additional, Duncan, C, additional, Mol, B, additional, Whitaker, L, additional, Jurkovic, D, additional, Coomarasamy, A, additional, Nunes, N, additional, Holland, T, additional, Clarke, F, additional, Doust, A, additional, and Daniels, J, additional
- Published
- 2023
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23. Experiences and perceptions of the United States Ebola Active Monitoring Program: results from a survey of Former Persons Under Monitoring in Washington, DC
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Hennenfent, A., McGee, S., Dassie, K., Grant, J., Li, K., Zamore, K., Davies-Cole, J., and Johnson-Clarke, F.
- Published
- 2017
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24. Reproductive Suppression in Female Damaraland Mole-Rats Cryptomys damarensis: Dominant Control or Self-Restraint?
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Clarke, F. M., Miethe, G. H., and Bennett, N. C.
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- 2001
25. Fundamentum electionis : the work and person of Christ in the theology of Jacobus Arminius
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Clarke, F. Stuart
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232 ,Christian doctrine - Published
- 2002
26. Variability in ultra cool dwarfs
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Clarke, F.
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520 - Abstract
Chapter one provides a brief overview of the physics of ultra cool dwarfs, and discusses relevant observation to date. Of particular import is an understanding of their atmospheric physics. The cool temperatures (2500K) of their atmospheres are condusive to the formation of molecules, the occurrence of chemistry and the condensation of solid and liquid particulates. The latter of these processes, which can be regarded as the formation of clouds, is especially interesting and poorly constrained by current theory and observation. One method of probing the structure, scale and distribution of clouds is to observe and characterise the variability they induce. In this dissertation, I present the results of observations designed to detect and characterise the photometric and spectroscopic variability induced by inhomogeneous cloud formations on ultra cool dwarfs. Chapters two and three describe observations and modelling of the brown dwarf Kelu-1. I report the discovery of a 1.8 hour periodicity in the object's brightness and discuss models to explain it. Chapter three then describes observations designed to test these models, and the conclusions that can be drawn from them. Observations of four further ultra cool dwarfs are described in chapter 4, and I report the discovery of photometric variability in two of them. These three chapters together form the most sensitive study of variability in ultra cool dwarfs made to date. In chapter five I discuss the possibility of imaging extrasolar plants and brown dwarfs around nearby white dwarfs. If discovered, these objets would be the "coolest" ultra cool dwarf known. Chapter six contains conclusions, and a brief summary of potential future work in this field.
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- 2002
27. Kin Discrimination and Female Mate Choice in the Naked Mole-Rat Heterocephalus glaber
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Clarke, F. M. and Faulkes, C. G.
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- 1999
28. H. J. S. Smith and the Fermat Two Squares Theorem
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Clarke, F. W., Everitt, W. N., Littlejohn, L. L., and Vorster, S. J. R.
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- 1999
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29. Partial Subdifferentials, Derivates and Rademacher's Theorem
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Bessis, D. N. and Clarke, F. H.
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- 1999
30. Hormonal and Behavioural Correlates of Male Dominance and Reproductive Status in Captive Colonies of the Naked Mole-Rat, Heterocephalus glaber
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Clarke, F. M. and Faulkes, C. G.
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- 1998
31. Dominance and Queen Succession in Captive Colonies of the Eusocial Naked Mole-Rat, Heterocephalus glaber
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Clarke, F. M. and Faulkes, C. G.
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- 1997
32. A French/English dialogue in architecture and interior decoration from the mid-eighteenth century until the years between the Great Wars
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Andreae, Clarke F.
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720 ,Architecture - Published
- 1997
33. Long-term (180-day) outcomes in critically ill patients with COVID-19 in the REMAP-CAP randomized clinical trial
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Florescu, S, Stanciu, D, Zaharia, M, Kosa, A, Codreanu, D, Kidwai, A, Masood, S, Kaye, C, Coutts, A, MacKay, L, Summers, C, Polgarova, P, Farahi, N, Fox, E, McWilliam, S, Hawcutt, D, Rad, L, O’Malley, L, Whitbread, J, Jones, D, Dore, R, Saunderson, P, Kelsall, O, Cowley, N, Wild, L, Thrush, J, Wood, H, Austin, K, Bélteczki, J, Magyar, I, Fazekas, Á, Kovács, S, Szőke, V, Donnelly, A, Kelly, M, Smyth, N, O’Kane, S, McClintock, D, Warnock, M, Campbell, R, McCallion, E, Azaiz, A, Charron, C, Godement, M, Geri, G, Vieillard-Baron, A, Johnson, P, McKenna, S, Hanley, J, Currie, A, Allen, B, McGoldrick, C, McMaster, M, Mani, A, Mathew, M, Kandeepan, R, Vignesh, C, TV, B, Ramakrishnan, N, James, A, Elvira, E, Jayakumar, D, Pratheema, R, Babu, S, Ebenezer, R, Krishnaoorthy, S, Ranganathan, L, Ganesan, M, Shree, M, Guilder, E, Butler, M, Cowdrey, K-A, Robertson, M, Ali, F, McMahon, E, Duffy, E, Chen, Y, Simmonds, C, McConnochie, R, O’Connor, C, El-Khawas, K, Richardson, A, Hill, D, Commons, R, Abdelkharim, H, Saxena, M, Muteithia, M, Dobell-Brown, K, Jha, R, Kalogirou, M, Ellis, C, Krishnamurthy, V, O’Connor, A, Thurairatnam, S, Mukherjee, D, Kaliappan, A, Vertue, M, Nicholson, A, Riches, J, Maloney, G, Kittridge, L, Solesbury, A, Ramos, A, Collins, D, Brickell, K, Reid, L, Smyth, M, Breen, P, Spain, S, Curley, G, McEvoy, N, Geoghegan, P, Clarke, J, Silversides, J, McGuigan, P, Ward, K, O’Neill, A, Finn, S, Wright, C, Green, J, Collins, É, Knott, C, Smith, J, Boschert, C, Slieker, K, Ewalds, E, Sanders, A, Wittenberg, W, Geurts, H, Poojara, L, Sara, T, Nand, K, Reeve, B, Dechert, W, Phillips, B, Oritz-Ruiz de Gordoa, L, Affleck, J, Shaikh, A, Murray, A, Ramanan, M, Frakking, T, Pinnell, J, Robinson, M, Gledhill, L, Wood, T, Sanghavi, R, Bhonagiri, D, Ford, M, Parikh, HG, Avard, B, Nourse, M, McDonald, B, Edmunds, N, Hoiting, O, Peters, M, Rengers, E, Evers, M, Prinssen, A, Morgan, M, Cole, J, Hill, H, Davies, M, Williams, A, Thomas, E, Davies, R, Wise, M, Grimm, P, Soukup, J, Wetzold, R, Löbel, M, Starke, L, Lellouche, F, Lizotte, P, Declerq, P, Antoine, M, Stephanie, G, Jean-Pierre, E, François, B, Marion, B, Philippe, R, Pourcine, F, Monchi, M, Luis, D, Mercier, R, Sagnier, A, Verrier, N, Caplin, C, Richecoeu, J, Combaux, D, Siami, S, Aparicio, C, Vautier, S, Jeblaoui, A, Lemaire-Brunel, D, D'Aragon, F, Carbonneau, E, Leblond, J, Plantefeve, G, Leparco, C, Contou, D, Fartoukh, M, Courtin, L, Labbe, V, Voiriot, G, Salhi, S, Chassé, M, Carrier, F, Boumahni, D, Benettaib, F, Ghamraoui, A, Sement, A, Gachet, A, Hanisch, A, Haffiane, A, Boivin, A-H, Barreau, A, Guerineau, E, Poupblanc, S, Egreteau, P, Lefevre, M, Bocher, S, Le Loup, G, Le Guen, L, Carn, V, Bertel, M, Antcliffe, D, Templeton, M, Rojo, R, Coghlan, P, Smee, J, Barker, G, Finn, A, Kreb, G, Hoff, U, Hinrichs, C, Nee, J, Mackay, E, Cort, J, Whileman, A, Spencer, T, Spittle, N, Beavis, S, Padmakumar, A, Dale, K, Hawes, J, Moakes, E, Gascoyne, R, Pritchard, K, Stevenson, L, Cooke, J, Nemeth-Roszpopa, K, Gauli, B, Bastola, S, Muller, G, Nay, M-A, Kamel, T, Benzekri, D, Jacquier, S, Runge, I, Mathonnet, A, Barbier, F, Bretagnol, A, Carter, J, Van Der Heyden, K, Mehrtens, J, Morris, A, Morgan, S, Burke, T, Mercier, E, Chartier, D, Salmon, C, Dequin, P-F, Garot, D, Bellemare, D, Cloutier, È, Daher, R, Costerousse, O, Boulanger, M-C, Couillard-Chénard, É, Lauzier, F, Francoeur, C, Francois, B, Gay, A, Anne-Laure, F, Ramali, M, HC, O, Ghosh, A, Osagie, R, Arachchige, M, Hartley, M, Cheung, W, Wong, H, Seigne, P, Eustace, J, O'Callaghan, A-M, O'Brien, F, Bamford, P, Reid, A, Cawley, K, Faulkner, M, Pickering, C, Raj, A, Tsinaslanidis, G, Khade, R, Agha, G, Sekiwala, R, Smith, T, Brewer, C, Gregory, J, Limb, J, Cowton, A, O’Brien, J, Postlethwaite, K, Malakouti, S, Music, E, Ricketts, D, King, A, Clermont, G, Bart, R, Mayr, F, Schoenling, A, Andreae, M, Shetty, V, Brant, E, Malley, B, Donadee, C, Sackrowitz, R, Weissman, A, Yealy, D, Barton, D, Talia, N, Nikitas, N, Wells, C, Lankester, L, McMillan, H, Van den Oever, H, Kruisdijk-Gerritsen, A, Haidar, G, Bain, W, Barbash, I, Fitzpatrick, M, Franz, C, Kitsios, G, Moghbeli, K, Rosborough, B, Shah, F, Suber, T, Pulletz, M, Williams, P, Birch, J, Wiseman, S, Horton, S, Alegria, A, Turki, S, Elsefi, T, Crisp, N, Allen, L, Truman, N, Smith, M, Chukkambotla, S, Goddard, W, Duberley, S, Khan, M, Kazi, A, Simpson, J, Duke, G, Chan, P, Carter, B, Hunter, S, Voigt, I, Schueler, R, Blank, E, Hüning, V, Steffen, M, Goralski, P, Litton, E, Regli, A, Pellicano, S, Palermo, A, Eroglu, E, Bihari, S, Laver, RD, Jin, X, Brown, J, McIntyre, J, French, C, Bates, S, Towns, M, Yang, Y, McGain, F, McCullagh, I, Cairns, T, Hanson, H, Patel, B, Clement, I, Evetts, G, Touma, O, Holland, S, Hodge, C, Taylor, H, Alderman, M, Barnes, N, Da Rocha, J, Smith, C, Brooks, N, Weerasinghe, T, Sinclair, J-A, Abusamra, Y, Doherty, R, Cudlipp, J, Singh, R, Yu, H, Daebis, A, Ng, C, Kendrick, S, Saran, A, Makky, A, Greener, D, Rowe-Leete, L, Edwards, A, Bland, Y, Dolman, R, Foster, T, Laffey, J, McNicholas, B, Scully, M, Casey, S, Kernan, M, Brennan, A, Rangan, R, Tully, R, Corbett, S, McCarthy, A, Duffy, O, Burke, D, Linnett, V, Sanderson, A, Ritzema, J, Wild, H, Lucas, R, Marriott, Y, Andric, Z, Cviljevic, S, Br, R, Zapalac, M, Mirković, G, Khare, D, Pinder, M, Gopinath, A, Kannan, T, Dean, S, Vanmali, P, Depuydt, P, De Waele, J, De Bus, L, Fierens, J, Bracke, S, Vermassen, J, Vermeiren, D, Pugh, R, Lean, R, Qiu, X, Scanlan, J, Evans, A, Davies, G, Lewis, J, Plesnikova, Y, Khoud, A, Coetzee, S, Puxty, K, Cathcart, S, Rimmer, D, Bagot, C, Scott, K, Martin, L, Yusuff, H, Isgro, G, Brightling, C, Bourne, M, Craner, M, Boyles, R, Alexander, B, Roberts, T, Nelli, A, Rosenstein-Sisson, R, Speyer, R, Pech, Y, McCullough, J, Tallott, M, Vazquez-Grande, G, Marten, N, Liu, T, Siddiqui, A, Khanal, S, Amatya, S, Szakmany, T, Cherian, S, Williams, G, James, C, Waters, A, Prout, R, Stedman, R, Davies, L, Pegler, S, Kyeremeh, L, Moorhouse, L, Arbane, G, Marotti, M, Bociek, A, Campos, S, Van Nieuwkoop, K, Ottens, T, Visser, Y, Van den Berg, L, Van der Kraan-Donker, A, Brett, S, Arias, S, Hall, R, Paneru, H, Koirala, S, Paudel, P, Wilson, M, Vaara, S, Pettilä, L, Heinonen, J, Pettilä, V, Jain, S, Gupta, A, Holbrook, C, Antoine, P, Meziani, F, Allam, H, Cattelan, J, Clere-Jehl, R, Helms, J, Kummerlen, C, Merdji, H, Monnier, A, Rahmani, H, Studer, A, Schneider, F, Castelain, V, Morel, G, L’Hotellier, S, Ochin, E, Vanjak, C, Rouge, P, Bendjemar, L, Albert, M, Serri, K, Cavayas, A, Duplaix, M, Williams, V, Catorze, NJTADS, Pereira, TNAL, Ferreira, RMC, Bastos, JMPS, Batista, TMO, Badie, J, Berdaguer, F, Malfroy, S, Mezher, C, Bourgoin, C, Moneger, G, Bouvier, E, Muñoz-Bermúdez, R, Marin-Corral, J, Degracia, A, Gómez, F, López, M, Aceto, R, Aghemo, A, Badalamenti, S, Brunetta, E, Cecconi, M, Ciccarelli, M, Constantini, E, Greco, M, Folci, M, Selmi, C, Voza, A, Henning, J, Bonner, S, Hugill, K, Cirstea, E, Wilkinson, D, Jones, J, Altomy, M, Karlikowski, M, Sutherland, H, Wilhelmsen, E, Woods, J, North, J, Pletz, M, Hagel, S, Ankert, J, Kolanos, S, Bloos, F, Simons, K, Van Zuylen, T, Bouman, A, Kumar, N, Panwar, R, Poulter, A-L, Sunkara, K, Szigligeti, G, Leszkoven, J, Rochwerg, B, Karachi, T, Oczkowski, S, Centofanti, J, Millen, T, Sundaran, D, Hollos, L, Turns, M, Walsh, J, Al Qasim, E, Alswaidan, L, Hegazy, M, Arishi, H, Al Amri, A, AlQahtani, S, Naidu, B, Tlayjeh, H, Hussain, S, Al Enezi, F, Abdukahil, SA, Hopkins, P, Noble, H, O’Reilly, K, Mehta, R, Wong, O, Makanju, E, Rao, D, Sikondari, N, Saha, S, Corcoran, E, Pappa, E, Cockrell, M, Donegan, C, Balaie, M, Nickoleit-Bitzenberger, D, Schaaf, B, Meermeier, W, Prebeg, K, Azzaui, H, Hower, M, Brieger, K-G, Elender, C, Sabelhaus, T, Riepe, A, Akamp, C, Kremling, J, Klein, D, Landsiedel-Mechenbier, E, Laha, S, Verlander, M, Jha, A, Megarbane, B, Voicu, S, Deye, N, Malissin, I, Sutterlin, L, Mrad, A, Lehalleur, A, Naim, G, Nguyen, P, Ekhérian, J-M, Boué, Y, Sidéris, G, Vodovar, D, Guérin, E, Grant, C, Brain, M, Mineall, S, Paramasivam, E, Wilby, E, Ogg, B, Howcroft, C, Aspinwall, A, Charlton, S, Gould, R, Mistry, D, Awan, S, Bedford, C, Carr-Wilkinson, J, Hall, A, Gardiner-Hill, C, Maloney, C, Brunskill, N, Watchorn, O, Hardy, C, Qureshi, H, Flint, N, Nicholson, S, Southin, S, Ghattaoraya, A, Harding, D, O’Halloran, S, Collins, A, Smith, E, Trues, E, Borgatta, B, Turner-Bone, I, Reddy, A, Wilding, L, Wilson, C, Surti, Z, Aneman, A, Miller, J, White, H, Estensen, K, Morrison, L, Sutton, J, Cooper, M, Warnapura, L, Agno, R, Sathianathan, P, Shaw, D, Ijaz, N, Spong, A, Sabaretnam, S, Burns, D, Lang, E, Tate, M, Fischer, R, Biradar, V, Soar, N, Golden, D, Davey, M, Seaman, R, Osborne, A, Bannard-Smith, J, Clark, R, Birchall, K, Henry, J, Pomeroy, F, Quayle, R, Wylie, K, Sukuraman, A, John, M, Sibin, S, Leditschke, A, Finnis, M, Jongebloed, K, Khwaja, K, Campisi, J, Van Vonderen, M, Pietersma, M, Vrolijk, L, Kampschreur, L, Van Gulik, L, Makowski, A, Misztal, B, Haider, S, Liao, A, Squires, R, Oborska, A, Kayani, A, Kalchko-Veyssal, S, Prabakaran, R, Hadebe, B, KalchkoVeyssal, S, Williams, T, Song, R, Morpeth, S, Lai, V, Habraken, H, Stewart, R, Mwaura, E, Mew, L, Wren, L, Willams, F, Sutherland, S-B, Rebello, R, Shehabi, Y, Al-Bassam, W, Hulley, A, Kadam, U, Sathianathan, K, Innes, R, Doble, P, Graham, L, Shovelton, C, Dean, T, Salahuddin, N, Aryal, D, Koirala, K, Rai, N, Luitel, S, Seppelt, I, Whitehead, C, Lowrey, J, Gresham, R, Masters, K, Hamlyn, V, Hawkins, N, Roynon-Reed, A, Cutler, S, Lewis, S, Lazaro, J, Newman, T, Aravindan, L, Asghar, A, Bartholomew, J, Bayne, M, Beddows, S, Birch, C, Brend, M, Byrne, R, Campbell, D, Campbell, H, Chambers, E, Clinton, A, Collins, J, Crawshaw, S, Dawson, LA, Donaldson, K, Drake, C, Dyas, S, Ellis, Y, Gilmour, K, Goodwin, J, Halden, S, Hall, AS, Hanson, J, Harper, H, Harrison, S, Hayes, A, Hodgson, H, Hurford, S-A, Jackson, S, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, Marsh, E, Mguni, N, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, O'Kell, E, Oliver, A, O'Reilly, J, Pearson, K, Porter, D, Potter, A, Rook, C, Rounds, C, Sheffield, J, Shirley, K, Siewersk, C, Skinner, T, Speight, H, Sutu, M, Unsworth, A, Van’t Hoff, W, Walker, S, Williams, H, Williamson, D, Williamson, JD, Duan, E, Tsang, J, Patterson, L, Austin, P, Chapman, S, Cabrelli, L, Fletcher, S, Nortje, J, Fottrell-Gould, D, Randell, G, Stammers, K, Healey, G, Pinto, M, Borrill, Z, Duncan, T, Ustianowski, A, Uriel, A, Eltayeb, A, Alfonso, J, Hey, S, Shaw, J, Fox, C, Lindergard, G, Charles, B, Blackledge, B, Connolly, K, Harris, J, Cuesta, J, Xavier, K, Purohit, D, Elhassan, M, Haldeos, A, Vincent, R, Abdelrazik, M, Jenkins, S, Ganesan, A, Kumar, R, Carter, D, Bakthavatsalam, D, Frater, A, Saleem, M, Everitt, R, Hacking, D, Zaman, M, Elmahi, E, Jones, A, Hall, K, Phillips, M, Terrill, L, Mills, G, Raithatha, A, Bauchmuller, K, Ryalls, K, Harrington, K, Bowler, H, Sall, J, Bourne, R, Gross, J, Massey, N, Adebambo, O, Long, M, Tony, K, Juffermans, N, Koopmans, M, Dujardin, R, Alderink, B, Rowland, M, Hutton, P, Bashyal, A, Davidson, N, Hird, C, Chhablani, M, Phalod, G, Kirkby, A, Archer, S, Netherton, K, Reschreiter, H, Camsooksai, J, Patch, S, Humphrey, C, Flynn, G, Harrington, C, Kruger, P, Walsham, J, Meyer, J, Harward, M, Jones, C, Sathe, S, Roche, L, Davies, E, Skinner, D, Gaylard, J, Newman, J, Pogson, D, Rose, S, Daly, Z, Brimfield, L, Nown, A, Parekh, D, Bergin, C, Bates, M, McGhee, C, Lynch, D, Bhandal, K, Tsakiridou, K, Bamford, A, Cooper, L, Whitehouse, T, Veenith, T, Forster, E, O'Connell, M, Sim, M, Hay, S, Henderson, S, Nygren, M, Valentine, E, Katary, A, Bell, G, Wilcox, L, Mataliotakis, M, Smith, P, Ali, M, Isguzar, A, Phull, M-K, Zaidi, A, Pogreban, T, Rosaroso, L, Harvey, D, Lowe, B, Meredith, M, Ryan, L, Schouten, J, Pickkers, P, Roovers, N, Klop-Riehl, M, Van der Eng, H, Sloots-Cuppen, S, Preijers, L, Van Oosten, N, Moine, P, Heming, N, Maxime, V, Bossard, I, Nicholier, T, Clair, B, Orlikowski, D, Bounab, R, Abdeladim, L, Baker, S, Duroux, M, Ratcliffe, M, Sy, E, Mailman, J, Lee, S, Gupta, C, Kassir, S, López, R, Rodríguez-Gómez, J, Cárcel, S, Carmona, R, De la Fuente, C, Rodriguez, M, Jan Hassing, R, Greven, F, Huijbens, D, Roebers, L, Verheij, H, Miles, H, Attokaran, A, Buehner, U, Williams, E, Chapman, M, O’Connor, S, Glasby, K, Rivett, J, Brown, N, Kutsogiannis, D, Thompson, P, Rooney, K, Rodden, N, Thomson, N, McGlynn, D, Abel, L, Gemmell, L, Sundaram, R, Hornsby, J, Walden, A, Keating, L, Frise, M, Rai, S, Bartley, S, Schuster-Bruce, M, Pitts, S, Miln, R, Purandare, L, Vamplew, L, Dempster, D, Gummadi, M, Dormand, N, Wang, S, Spivey, M, Bean, S, Burt, K, Moore, L, Hammonds, F, Richards, C, Campbell, L, Smyth, K, Day, C, Zitter, L, Benyon, S, Singh, J, Lynch, C, Mikusek, J, Deacon, B, Turner, K, Baker, E, Hickey, J, Champanerkar, S, Aitken, L, LewisProsser, L, Ahmad, N, Wiles, M, Willson, J, Grecu, I, Martin, J, Wrey Brown, C, Arias, A-M, Bevan, E, Westlake, S, Craven, T, Hope, D, Singleton, J, Clark, S, McCulloch, C, Biddie, S, Welters, I, Hamilton, D, Williams, K, Waugh, V, Mulla, S, Waite, A, Roman, J, Martinez, M, Johnston, B, Puthucheary, Z, Martin, T, Santos, F, Uddin, R, Fernandez, M, Seidu, F, Somerville, A, Pakats, M-L, Begum, S, Shahid, T, Presneill, J, Barge, D, Byrne, K, Janin, P, Yarad, E, Bass, F, Hammond, N, Vuylsteke, A, Chan, C, Victor, S, Waterson, S, McNamara, R, Boardman, M, Gattas, D, Buhr, H, Coles, J, Matsa, R, Gellamucho, M, Creagh-Brown, B, Marriot, C, Salberg, A, Zouita, L, Stone, S, Michalak, N, Donlon, S, Mtuwa, S, Mayangao, I, Verula, J, Burda, D, Harris, C, Jones, E, Bradley, P, Tarr, E, Harden, L, Piercy, C, Nolan, J, Kerslake, I, Cook, T, Simpson, T, Dalton, J, Demetriou, C, Mitchard, S, Ramos, L, White, K, Johnson, T, Headdon, W, Spencer, S, White, A, Howie, L, Reay, M, Watts, A, Traverse, E, Jennings, S, Anumakonda, V, Tuckwell, C, Harrow, K, Matthews, J, McGarry, K, Moore, V, Smith, L, Summerfield, A, Dark, P, Harvey, A, Doonan, R, McMorrow, L, Knowles, K, Pendlebury, J, Perez, J, Marsden, T, Taylor, M, Michael, A, Collis, M, Claxton, A, Habeichi, W, Horner, D, Slaughter, M, Thomas, V, Proudfoot, N, Keatley, C, Donnison, P, Casey, R, Irving, B, Matimba-Mupaya, W, Reed, C, Anthony, A, Trim, F, Cambalova, L, Robertson, D, Wilson, A, Hulme, J, Kannan, S, Kinney, F, Senya, H, Ratnam, V, Gill, M, Kirk, J, Shelton, S, Schweikert, S, Wibrow, B, Anstey, M, Rauniyar, R, Khoso, N, Asif, N, Taqdees, H, Frey, C, Scano, R, McKee, M, Murphy, P, Thomas, M, Worner, R, Faulkner, B, Gendall, E, Hayes, K, Blakemore, H, Borislavova, B, Deshpande, K, Van Haren, F, Konecny, P, Inskip, D, Tung, R, Hayes, L, Murphy, L, Neill, A, Reidy, B, O’Dwyer, M, Ryan, D, Ainscough, K, Hamilton-Davies, C, Mfuko, C, Abbass, H, Mandadapu, V, Leaver, S, Patel, K, Farnell-Ward, S, Saluzzio, R, Rawlins, S, Sicat, C, De Keulenaer, B, Ferrier, J, Fysh, E, Davda, A, Mevavala, B, Cook, D, Clarke, F, Banach, D, Fernández de Pinedo Artaraz, Z, Cabreros, L, Latham, V, Kruisselbrink, R, Brochard, L, Burns, K, Sandhu, G, Khalid, I, White, I, Croft, M, Holland, N, Pereira, R, Nair, P, Buscher, H, Reynolds, C, Newman, S, Santamaria, J, Barbazza, L, Homes, J, Smith, R, Zaki, A, Johnson, D, Garrard, H, Juhaz, V, Brown, L, Pemberton, A, Roy, A, Rostron, A, Woods, L, Cornell, S, Fowler, R, Adhikari, N, Kamra, M, Marinoff, N, Garrett, P, Murray, L, Brailsford, J, Fennessy, G, Mulder, J, Morgan, R, Pillai, S, Harford, R, Ivatt, H, Evans, D, Richards, S, Roberts, E, Bowen, J, Ainsworth, J, Kuitunen, A, Karlsson, S, Vahtera, A, Kiiski, H, Ristimäki, S, Albrett, J, Jackson, C, Kirkham, S, Tamme, K, Reinhard, V, Ellervee, A, Põldots, L, Rennit, P, Svitškar, N, Browne, T, Grimwade, K, Goodson, J, Keet, O, Callender, O, Udy, A, McCracken, P, Young, M, Board, J, Martin, E, Kasipandian, V, Patel, A, Allibone, S, Mary-Genetu, R, English, S, Watpool, I, Porteous, R, Miezitis, S, McIntyre, L, Brady, K, Vale, C, Shekar, K, Lavana, J, Parmar, D, Peake, S, Kurenda, C, Hormis, A, Walker, R, Collier, D, Kimpton, S, Oakley, S, Bhagani, S, De Neef, M, Garcia, S, Maharajh, A, Nandani, A, Dobson, J, Fernando, G, Eastgate, C, Gomez, K, Abdi, Z, Tatham, K, Jhanji, S, Black, E, Dela Rosa, A, Howle, R, Baikady, R, Drummond, A, Dearden, J, Philbin, J, Munt, S, Gopal, S, Pooni, J-S, Ganguly, S, Smallwood, A, Metherell, S, Naeem, A, Fagan, L, Ryan, E, Mariappa, V, Foulds, A, Revill, A, Bhattarai, B, De Jonge, E, Wigbers, J, Del Prado, M, Cremer, O, Mulier, J, Peters, A, Romberg, B, Schutgens, R, Troeman, D, Van Opdorp, M, Besten, H, Brakké, K, Barber, R, Hilldrith, A, Kluge, S, Nierhaus, A, Jarczak, D, Roedl, K, Kochanek, M, Rueß-Paterno, G, Mc-Kenzie, J, Eichenauer, D, Shimabukuro-Vornhagen, A, Wilcox, E, Del Sorbo, L, Abdelhady, H, Romagnuolo, T, Simpson, S, Maiden, M, Horton, M, Trickey, J, Krajinovic, V, Kutleša, M, Kotarski, V, Brohi, F, Jagannathan, V, Clark, M, Purvis, S, Wetherill, B, Brajković, A, Babel, J, Sever, H, Dragija, L, Kušan, I, Dushianthan, A, Cusack, R, De Courcy-Golder, K, Salmon, K, Burnish, R, Smith, S, Ruiz, W, Duke, Z, Johns, M, Male, M, Gladas, K, Virdee, S, Swabe, J, Tomlinson, H, Rohde, G, Grünewaldt, A, Bojunga, J, Petros, S, Kunz, K, Schütze, B, Weismann, D, Frey, A, Drayss, M, Goebeler, ME, Flor, T, Fragner, G, Wahl, N, Totzke, J, Sayehli, C, Hakak, S, Altaf, W, O'Sullivan, M, Murphy, A, Walsh, L, Rega La Valle, A, Bewley, J, Sweet, K, Grimmer, L, Johnson, R, Wyatt, R, Morgan, K, Varghese, S, Willis, J, Stratton, E, Kyle, L, Putensen, D, Drury, K, Skorko, A, Bremmer, P, Ward, G, Bassford, C, Sligl, W, Baig, N, Rewa, O, Bagshaw, S, Basile, K, Stavor, D, Burbee, D, McNamara, A, Wunderley, R, Bensen, N, Adams, P, Vita, T, Buhay, M, Scholl, D, Gilliam, M, Winters, J, Doherty, K, Berryman, E, Ghaffari, M, Marroquin, O, Quinn, K, Garrard, W, Kalchthaler, K, Beard, G, Skrtich, A, Bagavathy, K, Drapola, D, Bryan-Morris, K, Arnold, J, Reynolds, B, Hussain, M, Dunsavage, J, Saiyed, S, Hernandez, E, Goldman, J, Brown, C, Comp, S, Raczek, J, Morris, J, Vargas Jr., J, Weiss, D, Hensley, J, Kochert, E, Wnuk, C, Nemeth, C, Mowery, B, Hutchinson, C, Winters, L, McAdams, D, Walker, G, Minnier, T, Wisniewski, M, Mayak, K, McCreary, E, Bariola, R, Viehman, A, Daley, J, Lopus, A, Schmidhofer, M, Ambrosino, R, Keen, S, Toffalo, S, Stambaugh, M, Trimmer, K, Perri, R, Casali, S, Medva, R, Massar, B, Beyerl, A, Burkey, J, Keeler, S, Lowery, M, Oncea, L, Daugherty, J, Sevilla, C, Woelke, A, Dice, J, Weber, L, Roth, J, Ferringer, C, Beer, D, Fesz, J, Carpio, L, Colin, G, Zinzoni, V, Maquigneau, N, Henri-Lagarrigue, M, Pouplet, C, Reill, L, Distler, M, Maselli, A, Martynoga, R, Trask, K, Butler, A, Attwood, B, Parsons, P, Campbell, B, Smith, A, Page, V, Zhao, X, Oza, D, Abrahamson, G, Sheath, B, Young, P, Young, C, Lesona, E, Navarra, L, Cruz, R, Delaney, K, Aguilar-Dano, A, Gojanovic, M, Rhodes, J, Anderson, T, Morris, S, Nayyar, V, Bowen, D, Kong, J, Joy, J, Fuchs, R, Lambert, B, Tai, C, Thomas, A, Keen, A, Tierney, C, Omer, N, Bacon, G, Tridente, A, Shuker, K, Anders, J, Greer, S, Scott, P, Millington, A, Buchanan, P, Binnie, A, Powell, E, McMillan, A, Luk, T, Aref, N, Denmade, C, Sadera, G, Jacob, R, Hughes, D, Sterba, M, Geng, W, Digby, S, Southern, D, Reddy, H, Hulse, S, Campbell, A, Garton, M, Watkins, C, Smuts, S, Quinn, A, Simpson, B, McMillan, C, Finch, C, Hill, C, Cooper, J, Budd, J, Small, C, O’Leary, R, Collins, E, Holland, A, Alexander, P, Felton, T, Ferguson, S, Sellers, K, Ward, L, Yates, D, Birkinshaw, I, Kell, K, Scott, Z, Pearson, H, Hashmi, M, Hassan, N, Panjwani, A, Umrani, Z, Shaikh, M, Ain, Q, Kanwal, D, Van Bree, S, Bouw-Ruiter, M, Osinga, M, Van Zanten, A, McEldrew, R, Rashan, S, Singh, V, Azergui, N, Bari, S, Beltran, M, Brugman, C, Groeneveld, E, Jafarzadeh, M, Keijzer-Timmers, N, Kester, E, Koelink, M, Kwakkenbos-Craanen, M, Okundaye, C, Parker, L, Peters, S, Post, S, Rietveld, I, Scheepstra-Beukers, I, Schreuder, G, Smit, A, Brillinger, N, Markgraf, R, Eichinger, F, Doran, P, Anjum, A, Best-Lane, J, Barton, F, Miller, L, Richards-Belle, A, Saull, M, Sprinckmoller, S, Wiley, D, Darnell, R, Au, C, Lindstrum, K, Cheng, A, Forbes, A, Heritier, S, Trapani, T, Cuthbertson, B, Manoharan, V, Dondrop, A, Tolppa, T, Ehrmann, S, Hullegie, S, Povoa, P, Beasley, R, Daneman, N, McGloughlin, S, Paterson, D, Venkatesh, B, De Jong, M, Uyeki, T, Baillie, K, Netea, M, Orr, K, Patanwala, A, Tong, S, Cooper, N, Galea, J, Leavis, H, Ogungbenro, K, Patawala, A, Rademaker, E, Youngstein, T, Carrier, M, Fergusson, D, Hunt, B, Kumar, A, Laffan, M, Lother, S, Middeldorp, S, Stanworth, S, De Man, A, Masse, M-H, Abraham, J, Arnold, D, Begin, P, Charlewood, R, Chasse, M, Coyne, M, Daly, J, Gosbell, I, Harvala-Simmonds, H, MacLennan, S, McDyer, J, Menon, D, Pridee, N, Roberts, D, Thomas, H, Tinmouth, A, Triulzi, D, Walsh, T, Wood, E, Calfee, C, O’Kane, C, Shyamsundar, M, Sinha, P, Thompson, T, Young, I, Burrell, A, Ferguson, N, Hodgson, C, Orford, N, Phua, J, Baron, R, Epelman, S, Frankfurter, C, Gommans, F, Kim, E, Leaf, D, Vaduganathan, M, Van Kimmenade, R, Sanil, A, Van Beurden, M, Effelaar, E, Schotsman, J, Boyd, C, Harland, C, Shearer, A, Wren, J, Attanayaka, U, Darshana, S, Ishani, P, Udayanga, I, Higgins, AM, Berry, LR, Lorenzi, E, Murthy, S, McQuilten, Z, Mouncey, PR, Al-Beidh, F, Annane, D, Arabi, YM, Beane, A, Van Bentum-Puijk, W, Bhimani, Z, Bonten, MJM, Bradbury, CA, Brunkhorst, FM, Buzgau, A, Buxton, M, Charles, WN, Cove, M, Detry, MA, Estcourt, LJ, Fagbodun, EO, Fitzgerald, M, Girard, TD, Goligher, EC, Goossens, H, Haniffa, R, Hills, T, Horvat, CM, Huang, DT, Ichihara, N, Lamontagne, F, Marshall, JC, McAuley, DF, McGlothlin, A, McGuinness, SP, McVerry, BJ, Neal, MD, Nichol, AD, Parke, RL, Parker, JC, Parry-Billings, K, Peters, SEC, Reyes, LF, Rowan, KM, Saito, H, Santos, MS, Saunders, CT, Serpa-Neto, A, Seymour, CW, Shankar-Hari, M, Stronach, LM, Turgeon, AF, Turner, AM, Van de Veerdonk, FL, Zarychanski, R, Green, C, Lewis, RJ, Angus, DC, McArthur, CJ, Berry, S, Derde, LPG, Gordon, AC, Webb, SA, Lawler, PR, Comm REMAP-CAP Investigators, Apollo - University of Cambridge Repository, Intensive Care Medicine, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pittsburgh Foundation, PF, Amgen, Health Research Board, HRB: CTN 2014-012, Horizon 2020 Framework Programme, H2020: 101003589, Translational Breast Cancer Research Consortium, TBCRC, Canadian Institutes of Health Research, IRSC: 158584, Heart and Stroke Foundation of Canada, HSF, National Institute for Health and Care Research, NIHR, European Commission, EC, National Health and Medical Research Council, NHMRC: 1101719, APP194811, CS-2016-16-011, GNT2008447, RP-2015-06-18, Office of Health and Medical Research, OHMR, Health Research Council of New Zealand, HRC: 16/631, Eisai, Ministère des Affaires Sociales et de la Santé: PHRC-20-0147, Université Pierre et Marie Curie, UPMC, NIHR Imperial Biomedical Research Centre, BRC, Minderoo Foundation, Funding/Support : The Platform for European Preparedness Against (Re-) emerging Epidemics (PREPARE) consortium by the European Union, FP7-HEALTH-2013-INNOVATION-1 (#602525), the Rapid European COVID-19 Emergency Research response (RECOVER) consortium by the European Union’s Horizon 2020 research and innovation programme (#101003589), the Australian National Health and Medical Research Council (#APP1101719), the Australian Medical Research Future Fund (#APP2002132), the Health Research Council of New Zealand (#16/631), the Canadian Institutes of Health Research Strategy for Patient-Oriented Research Innovative Clinical Trials Program Grant (#158584) and the Canadian Institute of Health Research COVID-19 Rapid Research Funding (#447335), the UK National Institute for Health Research (NIHR) and the NIHR Imperial Biomedical Research Centre, the Health Research Board of Ireland (CTN 2014-012), the UPMC Learning While Doing Program, the Translational Breast Cancer Research Consortium, the French Ministry of Health (PHRC-20-0147), the Wellcome Trust Innovations Project (215522), the Minderoo Foundation, the EU Programme Emergency Support Instrument, the NHS Blood and Transplant Research and Development Programme, the Translational Breast Cancer Research Consortium, the NSW Office of Health and Medical Research, Amgen, Eisai, and the Pittsburgh Foundation. Dr Higgins is funded by an NHMRC Emerging Leadership Fellowship (GNT2008447). Dr McQuilten is funded by an NHMRC Emerging Leadership Fellowship (APP194811). Dr Gordon is funded by an NIHR Research Professorship (RP-2015-06-18) and Dr Shankar-Hari by an NIHR Clinician Scientist Fellowship (CS-2016-16-011). Dr Turgeon is the Chairholder of the Canada Research Chair in Critical Care Neurology and Trauma. Dr Lawler is supported by a career award from the Heart and Stroke Foundation of Canada., and European Project: 602525,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,PREPARE(2014)
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Adult ,Male ,corticosteroid ,[SDV]Life Sciences [q-bio] ,Critical Illness ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,antiplatelet ,Lopinavir ,Adaptive platform trial randomized controlled trial intensive care, pneumonia COVID-19 antiplatelet immunoglobulin antiviral corticosteroid immune modulation anticoagulation ,All institutes and research themes of the Radboud University Medical Center ,Adrenal Cortex Hormones ,Humans ,anticoagulation ,intensive care, pneumonia ,COVID-19 Serotherapy ,Original Investigation ,Medicine(all) ,immune modulation ,Ritonavir ,SARS-CoV-2 ,COVID-19 ,Anticoagulants ,Bayes Theorem ,General Medicine ,Middle Aged ,antiviral ,Receptors, Interleukin-6 ,Adaptive platform trial ,randomized controlled trial ,Female ,Human medicine ,immunoglobulin ,Follow-Up Studies ,Hydroxychloroquine - Abstract
ImportanceThe longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.ObjectiveTo determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.Design, Setting, and ParticipantsPrespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries. The final 180-day follow-up was completed on March 2, 2022.InterventionsPatients were randomized to receive 1 or more interventions within 6 treatment domains: immune modulators (n = 2274), convalescent plasma (n = 2011), antiplatelet therapy (n = 1557), anticoagulation (n = 1033), antivirals (n = 726), and corticosteroids (n = 401).Main Outcomes and MeasuresThe main outcome was survival through day 180, analyzed using a bayesian piecewise exponential model. A hazard ratio (HR) less than 1 represented improved survival (superiority), while an HR greater than 1 represented worsened survival (harm); futility was represented by a relative improvement less than 20% in outcome, shown by an HR greater than 0.83.ResultsAmong 4869 randomized patients (mean age, 59.3 years; 1537 [32.1%] women), 4107 (84.3%) had known vital status and 2590 (63.1%) were alive at day 180. IL-6 receptor antagonists had a greater than 99.9% probability of improving 6-month survival (adjusted HR, 0.74 [95% credible interval {CrI}, 0.61-0.90]) and antiplatelet agents had a 95% probability of improving 6-month survival (adjusted HR, 0.85 [95% CrI, 0.71-1.03]) compared with the control, while the probability of trial-defined statistical futility (HR >0.83) was high for therapeutic anticoagulation (99.9%; HR, 1.13 [95% CrI, 0.93-1.42]), convalescent plasma (99.2%; HR, 0.99 [95% CrI, 0.86-1.14]), and lopinavir-ritonavir (96.6%; HR, 1.06 [95% CrI, 0.82-1.38]) and the probabilities of harm from hydroxychloroquine (96.9%; HR, 1.51 [95% CrI, 0.98-2.29]) and the combination of lopinavir-ritonavir and hydroxychloroquine (96.8%; HR, 1.61 [95% CrI, 0.97-2.67]) were high. The corticosteroid domain was stopped early prior to reaching a predefined statistical trigger; there was a 57.1% to 61.6% probability of improving 6-month survival across varying hydrocortisone dosing strategies.Conclusions and RelevanceAmong critically ill patients with COVID-19 randomized to receive 1 or more therapeutic interventions, treatment with an IL-6 receptor antagonist had a greater than 99.9% probability of improved 180-day mortality compared with patients randomized to the control, and treatment with an antiplatelet had a 95.0% probability of improved 180-day mortality compared with patients randomized to the control. Overall, when considered with previously reported short-term results, the findings indicate that initial in-hospital treatment effects were consistent for most therapies through 6 months.
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- 2023
34. Inhibition of Klebsiella pneumoniae growth by selected Australian plants: natural approaches for the prevention and management of ankylosing spondylitis
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Winnett, V., Sirdaarta, J., White, A., Clarke, F. M., and Cock, I. E.
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- 2017
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35. Invariance, monotonicity, and applications
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Clarke, F. H., Ledyaev, Yu. S., Stern, R. J., Clarke, F. H., editor, Stern, R. J., editor, and Sabidussi, G., editor
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- 1999
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36. Effects of Novel Solid-stemmed Wheat Genotype on Cephus cinctus Norton and its Parasitoid Bracon cephi
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Wu, X.-H., Cárcamo, H.A., Beres, B.L., Clarke, F., DePauw, R., and Pang, B.-P.
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- 2013
37. Inner Approximation of State-Constrained Optimal Control Problems
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Clarke, F. H., Stern, R. J., Pardalos, Panos, editor, Hadjisavvas, Nicolas, editor, and Pardalos, Panos M., editor
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- 2001
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38. Predicting Interaction Sites between Glycolytic Enzymes and Cytoskeletal Proteins Employing the Concepts of the Molecular Recognition Theory
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Sheedy, R. J., Clarke, F. M., Hennig, W., editor, Nover, L., editor, Scheer, U., editor, dos Remedios, Cristobal G., editor, and Thomas, David D., editor
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- 2001
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39. A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey
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Oikonomidis, Lydia, Santangelo, Andrea M., Shiba, Yoshiro, Clarke, F. Hannah, Robbins, Trevor W., and Roberts, Angela C.
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- 2017
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40. The Effects of the Serious Illness Care Program (SICP) on Health Care Resource Utilization (HRU)
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Muscedere, John, Truelove, Amber Hastings, Stockley, Denise, Fowler, Jennifer, Barrie, Carol, Hafid, A., Guenter, D., Gallagher, E., Howard, M., You, J., Nidumolu, A., Lagrotteria, A., Motehayerarani, A., Virk, N., Sinnarajah, A., Human, T., Ying, I., Wong, H., Cummings, G., Pattullo, A., Wang, J., Lee, J., Moffat, D., Grinman, M., Montgomery, C. L., Rolfson, D. B., Stelfox, H. T., Zuege, D., Zygun, D. A., Hudson, D., Opgenorth, D., Bagshaw, S. M., Laur, C., Bell, J., Valaitis, R., Ray, S., Keller, H., Prevett, C., Fang, H., Shkredova, D., Xie, F., Zoratti, M., Gordon, C., Adachi, J., Phillips, S., Richardson, J., Tang, A., Ma, C., Riehm, L., Kendell, C., Urquhart, R., Burge, F., Kotecha, J., Martin, M., Jorgensen, M., Han, H., Dubé, D., Gutman, G., Sussman, T., DeVries, B., Gahagan, J., Brotman, S., Koo, E., Wegier, P., Embuldeniya, G., Ansari, S., Kobewka, D., O’Connor, E., Wu, P., Steinberg, L., Bell, C., Walton, T., Colstello, J., van Walraven, C., Downar, J., Wu, P. E., Costello, J., Wu, R., Frost, D., Kawaguchi, S., Mahtani, R., Toor, H., Goldman, R., Myers, J., Forster, A., Hladkowicz, E., Taljaard, M., Bryson, G., Beaulé, P. E., Gagné, S., Hamilton, G., Huang, A., Joanisse, J. A., Lavallée, L. T., MacDonald, D., Moloo, H., Thavorn, K., Yang, H., Forster, A. J., McIsaac, D. I., Sypes, E. E., de Grood, C., Parsons Leigh, J., Clement, F. M., Niven, D. J., Bitschy, A. M., Donald, E., Ewing, G., Grande, G., Sawatzky, R., Stajduhar, K. I., Parascandalo, F., Yu-Hin Siu, H., Delleman, B., Langevin, J., Mangin, D., Fang, Q., Price, D., Chan, D., Ting Wang, H., Nguyen, Q. D., Menard, C. A., Morinville, A., Hirdes, J. P., Hebert, P., Singh, J., Swinton, M., Morrison, J. M., Laur, C. V., Ebad, M., Dubin, J. A., Chen, H., Curtis, L.J., Bell, J. J., Gramlich, L. M., Keller, H. H., Dionne, J., Duan, E., Clarke, F., Hand, L., Millen, T., Sandu, G., Hodder, J., Santos, M., Shah, S., Trembley, M., Gomes, B., Leclair, L., Montroy, K., Watpool, I., Porteous, R., Acres, S., Foster, D., Auld, F., Williams, V., Marchand, J., Campisi, J., Alam, N., Lebrassier, M., Thompson, P., Hewer, T., Gilles, D., Hunt, M., Georgescu, I., Boyd, T., Lys, J., Marten, N., Campbell, E., Bentall, T., Kavikondala, K., Willems, S., Panchbhaya, Z., Booth, J., Ruddell, S., Richter, B., Tassy, D., Jesso, R., Marinoff, N., Perez, A., Kaur, N., Campbell, T., Lizotte, P., Lavoie, L., Dionne, M., Saunders, L., Zytaruk, N., Heels-Ansdell, D., Johnstone, J., Cook, D., Quinn, K. L., Campitelli, M. A., Diong, C., Daneman, N., Stall, N., Morris, A. M., Detsky, A. S., Jeffs, L., Maxwell, C. J., Bell, C. M., Bronskill, S. E., Alghamdi, M., Baracos, V., Karvellas, C., Churchill, T., Khadaroo, R. G., Moorhouse, P., Sampalli, T., Bedford, L., Edwards, L., Gibson, R., Mallery, L., Taylor, D., Warner, G., Harnish, A., Law, V., Lawson, B. J., Wood, S., Buckler, M., Fernandes, P., Elliott, J., Stolee, P., Ali, G., Dunichand-Hoedl, A., Salim, S. Y., Mazurak, V. C., Baracos, V. E., Heckman, G. A., Hebert, P. C., Costa, A. P., Arthur, S. A., Jones, A., Salam-White, L., Tanner, D., Negm, A. M., Kennedy, C. C., Ioannidis, G., Gajic-Veljanoski, O., Thabane, L., Adachi, J. D., Marr, S., Lau, A., Atkinson, S., Petruccelli, D., DeBeer, J., Winemaker, M., Avram, V., Williams, D., Armstrong, D., Lumb, B., Panju, A., Papaioannou, A., Boucher, A., Haesebaert, J., Freitas, A., Adekpedjou, R., Landry, M., Bourassa, H., Dawn, S., Croteau, J., Légaré, F., Takaoka, A. M., Clarke, F. J., Shears, M. S., Muscedere, J., Cook, D. J., Lee, A., Bouchard, D. R., Sénéchal, M., Mayo, A., Hrubeniuk, T. J., Keshavarz, M., Robertson, C., Read, E. A., Norris, C M., Meyer, S. R., Zibdawi, M., Marshall, H. D., Moody, E. M., Martin-Misener, R., Hawken, E. R., Boyd, J. G., Im, J., Mak, S., Upshur, R., Steinbreg, L., Kuluski, K., Van Damme, J., Delvin, M-E., Medves, J., Woddhouse, K., Sakamoto, M. L., Durepos, P., Ploeg, J., Akhtar-Danesh, N., Punia, H., Kaasalainen, S., Hewston, P., Kennedy, C., Merom, D., Patterson, C., Sztramko, R., Trainor, L., Grenier, A., Woolhouse, M., Petrella, A.F.M., Heath, M., Hyland, B., Fan, M., Hamilton, M., Reding, R., Trbovich, P., O’Reilly, D. M., O’Donnell, S., Bruning, P., Donovan, J., Anoveros-Barrera, A., Coletta, G., Jakubowski, J., Pritchard, J. M., Werner, G. E., Hoben, M., Estabrooks, C. A., Leaker, H. R., Holroyd-Leduc, J., Fox, L., Smallbone, J., Stinchcombe, A., Wilson, K., Kortes-Miller, K., Rees-Milton, K. J., Hulbert, M., Turner, M. E., Berger, C., Anastassiades, T. P., Hopman, W. M., Adams, M. A., Powley, W. L., Holden, R. M., Grewal, K., Sheets, D., Smith, A. P., Trites, M., Kennedy, M., MacDonald, S., Sivarajah, L., Lamarche, L., Giangregorio, A., Radcliffe, S., Ioannidi, G., Negm, A., Connolly, M. S., Klein, J. M., Huber, J. S., Safaraz, S., Foster, A. J., Simpson, J. A., Brunt, K.R., Elfassy, M. D., Munshi, L., Mehta, N., Martinez Guasch, F., Kamen, C., Burry, L., Soong, C., Mehta, S., McKay, S., Yetman, L., Slayter, J., McCollum, A., McGibbon, C. A., Jarrett, P., Robinson, B., Kolyvas, A., McCloskey, R., Gionet, S., Scheme, E., Harris, B., D’Aoust, T. R., Shao, T., Egan, R., Muscedere, J. G., Milne, B., Fitzpatrick, M., Yingwei Peng, P., Parlow, J., and Johnson, A. P.
- Subjects
Abstracts - Published
- 2019
41. Erratum to: Identification and mapping in spring wheat of genetic factors controlling stem rust resistance and the study of their epistatic interactions across multiple environments
- Author
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Singh, A., Knox, R. E., DePauw, R. M., Singh, A. K., Cuthbert, R. D., Campbell, H. L., Singh, D., Bhavani, S., Fetch, T., and Clarke, F.
- Published
- 2014
- Full Text
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42. Genetics of pre-harvest sprouting resistance in a cross of Canadian adapted durum wheat genotypes
- Author
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Singh, A. K., Knox, R. E., Clarke, J. M., Clarke, F. R., Singh, A., DePauw, R. M., and Cuthbert, R. D.
- Published
- 2014
- Full Text
- View/download PDF
43. Physicians declining patient enrollment in a critical care trial: a case study in thromboprophylaxis
- Author
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Cook, D., Arabi, Y., Ferguson, N. D., Heels-Ansdell, D., Freitag, A., McDonald, E., and Clarke, F.
- Subjects
Physicians -- Case studies -- Analysis ,Health care industry - Abstract
Purpose To analyze the frequency, rationale and determinants of attending physicians requesting that their eligible patients not be approached for participation in a thromboprophylaxis trial. Methods Research personnel in 67 centers prospectively documented eligible non-randomized patients due to physicians declining to allow their patients to be approached. Results In 67 centers, 3,764 patients were enrolled, but 1,460 eligible patients had no consent encounter. For 218 (14.9 %) of these, attending physicians requested that their patients not be approached. The most common reasons included a high risk of bleeding (31.2 %) related to fear of heparin bioaccumulation in renal failure, the presence of an epidural catheter, peri-operative status or other factors; specific preferences for thromboprophylaxis (12.4 %); morbid obesity (9.6 %); uncertain prognosis (6.4 %); general discomfort with research (3.7 %) and unclear reasons (17.0 %). Physicians were more likely to decline when approached by less experienced research personnel; considering those with >10 years of experience as the reference category, the odds ratios (OR) for physician refusals to personnel without trial experience was 10.47 [95 % confidence interval (CI) 2.19-50.02] and those with less than 10 years experience was 1.72 (95 % CI 0.61-4.84). Physicians in open rather than closed units were more likely to decline (OR 4.26; 95 % CI 1.27-14.34). Refusals decreased each year of enrollment compared to the pilot phase. Conclusions Tracking, analyzing, interpreting and reporting the rates and reasons for physicians declining to allow their patients to be approached for enrollment provides insights into clinicians' concerns and attitudes to trials. This information can encourage physician communication and education, and potentially enhance efficient recruitment., Author(s): D. Cook [sup.1] [sup.2], Y. Arabi [sup.5], N. D. Ferguson [sup.6] [sup.7] [sup.8], D. Heels-Ansdell [sup.4], A. Freitag [sup.3], E. McDonald [sup.4], F. Clarke [sup.4], S. Keenan [sup.9], G. [...]
- Published
- 2013
- Full Text
- View/download PDF
44. The theatre of university research?
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Clarke, F., Craig, R., and Amernic, J.
- Published
- 2000
45. CEDEFOP Forum (7th, Berlin, Germany, September 1991).
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European Centre for the Development of Vocational Training, Berlin (Germany). and Clarke, F. Alan
- Abstract
This narrative account summarizes the 2-day research forum of the European Centre for the Development of Vocational Training (CEDEFOP). Presentations focus on the central theme of the forum: new qualifications versus skill shortages. They include Kees Meijer's outline of the research undertaken in a series of national studies on skill shortages within the European Community action program for the vocational training of young people and Juergen Schmehr's description of the regional approach and methods adopted by the "Skill Needs Monitoring Project." Papers and contributions from Member States illustrate the different ways in which individual countries approach the assessment of skill needs. Summaries are provided of Hermann Schmidt's discussion of Germany's response to identifying changing skill needs; Pol Debaty's introduction of the concept of "autoinformation"; Yves Lichtenberger's description of the move toward a stronger decentralization in France; and Juan Garcia Moreno's call for a greater regionalization of effort with reference to the Spanish situation. A description of the second day's program uses the Luxembourg experience as an example of how the legislature has accounted for the situation and needs of a minority (Jean Tagliaferri). Other highlights include a description of the evaluation and development of the Training and Enterprise Councils in the United Kingdom (Judith Marquand) and a review of the results of a pathfinding study conducted as part of the development of a European Directory of Research in the field of vocational training. (YLB)
- Published
- 1991
46. Clinical Utility of Random Anti–Tumor Necrosis Factor Drug–Level Testing and Measurement of Antidrug Antibodies on the Long-Term Treatment Response in Rheumatoid Arthritis
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Jani, Meghna, Chinoy, Hector, Warren, Richard B., Griffiths, Christopher E. M., Plant, Darren, Fu, Bo, Morgan, Ann W., Wilson, Anthony G., Isaacs, John D., Hyrich, Kimme L., Barton, Anne, Prouse, P. J., Moitra, R. K., Shawe, D. J., Nisar, M., Fairburn, K., Nixon, J., Barnes, T., Hui, M., Coady, D., Wright, D., Morley, C., Raftery, G., Bracewell, C., Bridges, M., Armstrong, D., Chuck, A. J., Hailwood, S., Kumar, N., Ashok, D., Reece, R., OʼReilly, S. C., Ding, T., Badcock, L. J., Deighton, C. M., Raj, N., Regan, M. R., Summers, G. D., Williams, R. A., Lambert, J. R., Stevens, R., Wilkinson, C., Kelly, C. A., Hamilton, J., Heycock, C. R., Saravanan, V., Cope, A., Garrood, T., Ng, N., Kirkham, B., Green, M., Gough, A., Lawson, C., Das, D., Borbas, E., Wazir, T., Emery, P., Bingham, S., Bird, H. A., Conaghan, P. G., Pease, C. T., Wakefield, R. J., Buch, M., Bruce, I., Gorodkin, R., Ho, P., Parker, B., Smith, W., Jenkins, E., Mukhtyar, C., Gaffney, K., Macgregor, A. J., Marshall, T., Merry, P., DeSilva, C., Birrell, F. N., Crook, P. R., Szebenyi, B., Bates, D., James, D., Gillott, T., Alvi, A., Grey, C., Browning, J., McHale, J. F., Gaywood, I. C., Jones, A. C., Lanyon, P., Pande, I., Doherty, M., Gupta, A., Courtney, P. A., Srikanth, A., Abhishek, A., Das, L., Pattrick, M., Snowden, H. N., Bowden, A. P., Smith, E. E., Klimiuk, P., Speden, D. J., Naz, S., Ledingham, J. M., Hull, R. G., McCrae, F., Cooper, A., Young-Min, S. A., Wong, E., Shaban, R., Woolf, A. D., Davis, M., Hutchinson, D., Endean, A., Mewar, D., Tunn, E. J., Nelson, K., Kennedy, T. D., Dubois, C., Pauling, J., Korendowych, E., Jenkinson, T., Sengupta, R., Bhalla, A., McHugh, N., OʼNeil, T., Herrick, A. L., Jones, A. K., Cooper, R. G., Dixon, W. G., Harrison, B., Buckley, C. D., Carruthers, D. C., Elamanchi, R., Gordon, P. C., Grindulis, K. A., Khattak, F., Raza, K., Situnayake, K., Akil, M., Till, S., Dunkley, L., Tattersall, R., Kilding, R., Tait, T., Maxwell, J., Kuet, K.-P., Plant, M. J., Clarke, F., Fordham, J. N., Tuck, S., Pathare, S. K., Paul, A., Marguerie, C. P., Rigby, S. P., Dunn, N., Abbas, I., Filer, C., Abernethy, V. E., Clewes, A. R., Dawson, J. K., Kitas, G., Erb, N., Klocke, R., Whallett, A. J., Douglas, K., Pace, A., Sandhu, R., John, H., Shand, L., Lane, S., Foster, H., Griffiths, B., Griffiths, I., Kay, L., Ng, W.-F., Platt, P. N., Walker, D. J., Peterson, P., Lorenzi, A., Friswell, M., Thompson, B., Lee, M., Pratt, A., Hopkinson, N. D., Dunne, C. A., Quilty, B., Marks, J., Mukherjee, S., Mulherin, D., Chalam, S. V., Price, T., Sheeran, T., Venkatachalam, S., Baskar, S., Al-Allaf, W., McKenna, F., Shah, P., Filer, A., Bowman, S. J., Jobanputra, P., Rankin, E. C., Allen, M., Chaudhuri, K., Dubey, S., Price-Forbes, A., Ravindran, J., Samanta, A., Sheldon, P., Hassan, W., Francis, J., Kinder, A., Neame, R., Moorthy, A., Bukhari, M., Ottewell, L., Palkonyai, E., Hider, S., Hassell, A., Menon, A., Dowson, C., Kamath, S., Packham, J., Dutta, S., Price, S., Roddy, E., Paskins, Z., OʼReilly, D. T., Rajagopal, V., Bhagat, S., Chattopadhyay, C. B., Quinn, D., Isdale, A., Brown, A., Saleem, B., Foo, B., Al Saffar, Z., and Koduri, G.
- Published
- 2015
- Full Text
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47. Sertoli Cell Binding to Isolated Testicular Basement Membrane
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Enders, George C., Henson, John H., and Millette, Clarke F.
- Published
- 1986
48. The Development of Regionalized Lipid Diffusibility in the Germ Cell Plasma Membrane during Spermatogenesis in the Mouse
- Author
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Wolf, David E., Scott, B. Keyes, and Millette, Clarke F.
- Published
- 1986
49. Generation of Flagella by Cultured Mouse Spermatids
- Author
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Gerton, George L. and Millette, Clarke F.
- Published
- 1984
50. Temporal Expression of Membrane Antigens during Mouse Spermatogenesis
- Author
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Millette, Clarke F. and Bellvé, Anthony R.
- Published
- 1977
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