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144 results on '"Cirilli, N."'

15. Standards of care guidance for sweat testing; phase two of the ECFS quality improvement programme

Author

ECFS Diagnostic Network Working Group, Cirilli, N, Southern, K W, Barben, J, Vermeulen, F, Munck, A, Wilschanski, M, Nguyen-Khoa, Thao, Aralica, M, Simmonds, N J, De Wachter, E, Faculty of Medicine and Pharmacy, Clinical sciences, Physiotherapy, Human Physiology and Anatomy, and Pediatrics

Subjects
Pulmonary and Respiratory Medicine, integumentary system, Chlorides, Cystic Fibrosis, Pediatrics, Perinatology and Child Health, Infant, Newborn, Humans, Standard of Care, Sweat, Quality Improvement
Abstract

More than five decades after the introduction of the quantitative pilocarpine iontophoresis technique, surveys still highlight inconsistencies in the performance and reporting of sweat tests in Europe. The sweat test remains key for the Cystic Fibrosis (CF) diagnostic pathway for all age groups, as it reflects the basic pathophysiological defect in the sweat gland. It is also critical following newborn screening as a confirmatory diagnostic step. Despite its importance, sweat test quality is variable whether performed in the laboratory or as a point of care test. The ECFS DNWG aims to improve sweat test performance, taking into account the barriers and issues identified in the European survey; the previous step in the ECFS sweat test project. This manuscript proposes a grading of sweat test guidance from "acceptable" to "optimal", aiming to pragmatically improve quality while taking into account local situations, especially in resource-limited settings.

Published
2022

16. [Italian Cystic Fibrosis Registry (ICFR). Report 2019-2020]

Author

Campagna, G., Amato, A., Majo, F., Ferrari, G., Quattrucci, S., Padoan, R., Floridia, G., Salvatore, D., Carnovale, V., Puppo Fornaro, G., Angiolillo, A., Badolato, R., Battistini, F., Bernardi, M. A., Bertasi, S., Bignamin, I., Caloiero, M., Cannata, L., Carnicella, A., Castellani, C., Ciciretti, M. A., Cimino, G., Cipolli, M., Cirilli, N., Collura, M., Colombo, C., De Venuto, D., Di Sabatino, M, Donati, V., Fabrizi, B., Ficili, F., Francalanci, M., Giordano, P., Iansa, P., Laezza, C., Leonardi, S., Lucanto, M. C., Lucidi, V., Macchiaroli, A. M., Manca, A., Maschio, M., Mascotto, D., Mencarini, V., Messore, B., Moretti, P., Negri, A., Pantano, S., Palladino, N., Pintani, E., Pisano, G., Pisi, G., Pizzamiglio, G., Pradal, U., Raia, V., Redemagni, A., Ripani, P., Ros, M., Rotolo, N., Rottigni, S., Salvatore, M., Scarlata, A., Serio, L., Spaggiari, C., Taccetti, G., Taruscio, D., and Vitullo, P

Subjects
Adult, Male, CF referral centre, Adolescent, Cystic Fibrosis, [delta]F508, COVID-19, FEV, registry, BMI, Young Adult, CF support centre, Italy, cystic fibrosis, Child, Child, Preschool, Female, Humans, Pandemics, Registries, Preschool
Published
2022

17. Italian cystic fibrosis registry (ICFR): Report 2017-2018

Author

Campagna, G., Amato, A., Majo, F., Ferrari, G., Quattrucci, S., Padoan, R., Floridia, G., Salvatore, D., Carnovale, V., Fornaro, G. P., Taruscio, D., Salvatore, M., Angiolillo, A., Baldo, E., Battistini, F., Bernardi, M. A., Bertasi, S., Bignamini, E., Bisogno, A., Braggion, C., Caloiero, M., Cannata, L., Carnicella, A., Cellini, C., Ciciretti, M. A., Cimino, G., Cipolli, M., Cirilli, N., Collura, M., Colombo, C., Sabatino, M. D., Donati, V., Fabrizi, B., Ficili, F., Francalanci, M., Iansa, P., Laezza, C., Leonardi, S., Lucanto, M. C., Lucidi, V., Macchiaroli, A. M., Manca, A., Maschio, M., Mascotto, D., Mencarini, V., Messore, B., Minicucci, L., Moretti, P., Negri, A., Pantano, S., Palladino, N., Pintani, E., Pisano, G., Pisi, G., Pizzamiglio, G., Quattromano, E., Raia, V., Redemagni, A., Ros, M., Rotolo, N., Rottigni, S., Scarlata, A., Spaggiari, C., Taccetti, G., Vassanelli, C., and Vitullo, P.

Subjects
Adult, Male, CF referral centre, Registry, Adolescent, Cystic Fibrosis, [delta]F508, Cystic Fibrosis Transmembrane Conductance Regulator, FEV, BMI, Young Adult, CF support centre, Italy, Cystic fibrosis, Child, Female, Humans, Registries, Lung Transplantation
Published
2021

23. P005 Lessons from 5T;TG12

Author

Cirilli, N., primary, Munaretto, R., additional, Perticaroli, F., additional, Bruni, A., additional, Baiocco, N., additional, and Fabrizzi, B., additional

Published
2020
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25. Italian Cystic Fibrosis Registry (ICFR). Report 2015-2016

Author

Giordani, B., Amato, A., Majo, F., Ferrari, G., Quattrucci, S., Minicucci, L., Padoan, R., Floridia, G., Salvatore, D., Carnovale, V., Puppo Fornaro, G., Taruscio, D., Salvatore, M., Albera, C, Amato, A, Angiolillo, A, Baldo, E, Battistini, F, Bena, C, Bernardi, Mg, Bertasi, S, Bignamini, E, Bisogno, A, Braggion, C, Cannata, L, Carnicella, A, Carnovale, V, Ciciretti, Ma, Cipolli, M, Cirilli, N, Colombo, C, Cucchiara, S, Di Sabatino, M, Di Stefano, E, Fabrizi, B, Ferrari, G, Ficili, F, Floridia, G, Francalanci, M, Gagliardini, R, Giordani, B, Iansa, P, Laezza, C, Leonardi, S, Lucanto, Mc, Lucidi, V, Macchiaroli, Am, Magazzù, G, Majo, F, Manca, A, Maschio, M, Mascotto, D, Mencarini, V, Minicucci, L, Moretti, P, Negri, A, Padoan, R, Palladino, N, Pintani, E, Pisano, G, Pisi, G, Pizzamiglio, G, Quattrucci, S, Raia, V, Ratclif, L, Ros, M, Rotolo, N, Salvatore, D, Salvatore, M, Spaggiari, C, Taruscio, D, Tonelli, T, Tuccio, G, Vassanelli, C, Vitullo, P, and Zavataro L, .

Published
2019

27. Italian Cystic Fibrosis Registry. Report 2011-2014

Author

Barbara, Giordani, Annalisa, Amato, Fabio, Majo, Gianluca, Ferrari, Serena, Quattrucci, Laura, Minicucci, Rita, Padoan, Giovanna, Floridia, Gianna Puppo Fornaro, Domenica, Taruscio, Marco, Salvatore, Gruppo di lavoro RIFC, Albera, C, Amato, A, Angiolillo, A, Assael, Bm, Baldo, E, Battistini, F, Bena, C, Bernardi, Mg, Bertasi, S, Bignamini, E, Bisogno, A, Braggion, C, Cannata, L, Carnicella, A, Carnovale, V, Ciciretti, Ma, Cirilli, N, Collura, M, Colombo, C, Cucchiara, S, Di Sabatino, M, Di Stefano, E, Ferrari, G, Ficili, F, Floridia, G, Francalanci, M, Gagliardini, R, Giordani, B, Iansa, P, Laezza, C, La Rosa, M, Leonardi, S, Lucanto, Mc, Lucidi, V, Macchiaroli, Am, Magazzù, G, Majo, F, Manca, A, Mascotto, D, Mencarini, V, Minicucci, L, Moretti, P, Negri, A, Padoan, R, Palladino, N, Pintani, E, Pisano, G, Pisi, G, Pizzamiglio, G, Poli, F, Quattrucci, S, Raia, V, Ratclif, L, Ros, M, Rotolo, N, Salvatore, D, Salvatore, M, Spaggiari, C, Taruscio, D, Tonelli, T, Tuccio, G, and Zavataro, L.

Subjects
Registry, Cystic Fibrosis, Italy, Cystic Fibrosis, Registry, Italy
Published
2018

29. Italian Cystic Fibrosis Register - Report 2010

Author

Amato, A, Ferrigno, L, Salvatore, M, Toccaceli, V, Gruppo di lavoro RIFC/ICFR Working Group, Albera, C, Assael, B, Baldo, E, Battistini, F, Bena, C, Bernardi, M, Bertasi, S, Bignamini, E, Bisogno, A0, Braggion, C1, Cannata, L, Carnicella, A, Carnovale, V, Ciciretti, M, Cirilli, N, Collura, M, Colombo, C, Contoli, B, Cotichini, R, Cristadoro, S, Cucchiara, S, Ferrari, G, Ficili, F, Fogazza, D, Forte, F, Francalanci, M, Gagliardini, R, Iansa, P, Laezza, C, La Rosa, M, Lucidi, V, Magazzù, G, Majo, F, Manca, A, Mascotto, D, Mencarini, V, Minicucci, L, Moretti, P, Padoan, R, Pintani, E, Pisi, G, Pizzamiglio, G, Poli, F, Quattrucci, S, Raia, V, Ratclif, L, Ros, M, Salvatore, D, Seia, M, Spaggiari, C, Stazi, M, Taruscio, D, Tonelli, T, Tuccio, G, and Zavataro, L

Subjects
Registry, Cystic Fibrosis, Italy, Cystic Fibrosis, Registry, Italy
Published
2016

40. 10 The role of complex alleles in patients with cystic fibrosis and L997F

Author

Cirilli, N., primary, Terlizzi, V., additional, Nardiello, P., additional, Gagliardini, R., additional, Tosco, A., additional, Sepe, A., additional, Quarta, B.M., additional, Amato, N., additional, Improta, F., additional, Romano, R., additional, De Gregorio, F., additional, Casale, A., additional, Carnovale, V., additional, D'Agostino, M.A., additional, Raia, V., additional, and Castaldo, G., additional

Published
2013
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41. WS21.3 Clinical variability in patients with cystic fibrosis and D1152H mutation

Author

Terlizzi, V., primary, Ingino, R., additional, Elce, A., additional, Tosco, A., additional, Improta, F., additional, Cirilli, N., additional, Gagliardini, R., additional, Salvatore, D., additional, Carnovale, V., additional, D'Agostino, M.A., additional, Sepe, A., additional, Amato, N., additional, De Gregorio, F., additional, Casale, A., additional, Raia, V., additional, and Castaldo, G., additional

Published
2013
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48. Command and control: A learning disability.

Author

Cirilli, N.

Subjects
*COMMAND & control systems, *PERSONNEL management
Abstract

Advises on how to change the practice of command and control within the management system. Negative effect of the belief system on workers and organization; Development of skills centered on an internal belief of service; Value of differences in people; Trust building; Potential in people; Praise and recognition.

Published
1998

49. A survey of the prevalence, management and outcome of infants with an inconclusive diagnosis following newborn bloodspot screening for cystic fibrosis (CRMS/CFSPID) in six Italian centres

Author

Giovanni Taccetti, Vito Terlizzi, Valeria Raia, Kevin W Southern, L. Claut, Laura Marsiglio, Benedetta Fabrizzi, L. Zavataro, Antonella Tosco, Natalia Cirilli, Laura Moroni, Giuseppe Cimino, Paolo Bonomi, Antonio Angeloni, Carla Colombo, Silviana Timpano, Pietro Piccinini, Rita Padoan, Filippo Festini, Alice Castaldo, Marco Lucarelli, Terlizzi, V, Claut, L, Tosco, A, Colombo, C, Raia, V, Fabrizzi, B, Lucarelli, M, Angeloni, A, Cimino, G, Castaldo, A, Marsiglio, L, Timpano, S, Cirilli, N, Moroni, L, Festini, F, Piccinini, P, Zavataro, L, Bonomi, P, Taccetti, G, Southern, Kw, and Padoan, R.

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Male, Pediatrics, medicine.medical_specialty, Cystic Fibrosis, Population, Sweat chloride, Cystic Fibrosis Transmembrane Conductance Regulator, Cystic fibrosis, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Neonatal Screening, Surveys and Questionnaires, Gene profile, medicine, Prevalence, Humans, cystic fibrosis, neonatal screening, CRMS/CFSPID, education, Metabolic Syndrome, education.field_of_study, medicine.diagnostic_test, Sweat testing, business.industry, Clinical course, Infant, Newborn, Infant, medicine.disease, 030104 developmental biology, 030228 respiratory system, Italy, Child, Preschool, Pediatrics, Perinatology and Child Health, embryonic structures, Female, Metabolic syndrome, Chest radiograph, business, cystic fibrosis, CFSPID
Abstract

Objective We evaluated the prevalence, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene profile, clinical data, management and outcome for infants with a CFTR-related metabolic syndrome/CF Screen Positive, Inconclusive Diagnosis (CRMS/CFSPID) designation from six Italian centres. Methods All newborn bloodspot screening (NBS) positive infants born from January 2011 to August 2018 with a CF diagnosis or a CRMS/CFSPID designation were enrolled. Data on sweat testing, genetics, clinical course and management were collected. Results We enrolled 257 CF patientsand 336 infants with a CRMS/CFSPID designation (CF: CRMS/CFSPID ratio of 1:1.30).Blood immuno-reactive trypsinogen (IRT) was significantly lower in CRMS/CFSPID infants and the F508del variant accounted for only 20% of alleles. Children with CRMS/CFSPID showed a milder clinical course, pancreatic sufficiency compared to CF infants. Varied practice across centres was identified regarding sweat testing, chest radiograph (8-100%) and salt supplementation (11-90%). Eighteen (5.3%) CRMS/CFSPID infants converted or were reclassified to diagnosis of CF. Four infants (1.3%) developed a clinical feature consistent with a CFTR-related disorder (1.2%). Twenty-seven were re-classified as healthy carriers (8.0%) and 16 as healthy infants (4.8%). Conclusions We have identified considerable variability in the evaluation and management of infants with an inconclusive diagnosis following NBS across six Italian centres. CRMS/CFSPID is more regularly seen in this population compared to countries with higher prevalence of F508del.Conversion to a CF diagnosis was recorded in 18 (5.3%) of CRMS/CFSPID infants and in 16 was as a result of increasing sweat chloride concentration.

Published
2021

50. The Italian External Quality Assessment Program for Cystic Fibrosis Sweat Chloride Test: Does Active Participation Improve the Quality?

Author

Valeria Raia, Giuseppe Castaldo, Natalia Cirilli, Ettore Capoluongo, Annalisa Amato, Marco Salvatore, Rita Padoan, Carlo Corbetta, Fabrizio Tosto, Domenica Taruscio, Giovanna Floridia, Ubaldo Caruso, Federica Censi, Gianluca Ferrari, Salvatore, M., Amato, A., Floridia, G., Censi, F., Ferrari, G., Tosto, F., Padoan, R., Raia, V., Cirilli, N., Castaldo, G., Capoluongo, E., Caruso, U., Corbetta, C., and Taruscio, D.

Subjects
sweat test, medicine.medical_specialty, Quality Assurance, Health Care, diagnosis, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Sweat chloride, lcsh:Medicine, Cystic fibrosis, Article, cystic fibrosis, active participation, 03 medical and health sciences, 0302 clinical medicine, Chlorides, 030225 pediatrics, External quality assessment, medicine, Humans, Medical physics, Quality (business), Prospective Studies, 030212 general & internal medicine, Sweat, Sweat test, media_common, Accreditation, medicine.diagnostic_test, business.industry, lcsh:R, Public Health, Environmental and Occupational Health, choloride, external quality assessment, medicine.disease, Test (assessment), Active participation, Italy, quality, Cystic fibrosi, business, Diagnosi
Abstract

(1) Background: Diagnostic testing for cystic fibrosis (CF) is based on a sweat chloride test (SCT) considering the appropriate signs and symptoms of the disease and results of a gene mutation analysis. In 2014, the Istituto Superiore di Sanit&agrave, (ISS) established a pilot Italian external quality assessment program for CF SCT (Italian EQA-SCT), which is now a third party service carried out by the ISS. (2) Methods: The ongoing scheme is prospective, enrollment is voluntary, and the payment of a fee is required. Results are shared through a dedicated web-facility. Assessment covers the analysis, interpretation, and reporting of results. (3) Results: Thirteen, fifteen, sixteen, and fifteen different laboratories, respectively, participated from 2015 to 2016 and from 2018 to 2019 in the Italian EQA-SCT scheme. Eleven different laboratories participated each year in all four rounds of the Italian EQA-SCT. (4) Conclusions: The overall results obtained from the laboratories participating constantly clearly show that their qualitative and quantitative performance improved significantly. This is due to the opportunity&mdash, after receiving the EQA results&mdash, to constantly review their performance and address any inconsistencies. We firmly believe that participation in the EQA program will improve the quality of participating laboratories and that EQA participation should become mandatory as a fundamental requirement for laboratory accreditation.

Published
2020
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