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Background Reports of synchronous bilateral giant (>10 cm) phyllodes tumors of the breast are scant in the literature. Reconstruction of the two large defects created after bilateral mastectomies is a challenge. Our patient, a 45-year-old woman, had a borderline phyllodes tumor measuring 15.5×15×7.3 cm in the right breast and a malignant phyllodes tumor measuring 16×10×9.8 cm in the left breast. After bilateral mastectomy, the following two huge defects remained: a 15×15 cm defect in the right breast and a 18×15-cm defect in the left breast. Methods We used one donor site with two separated deep inferior epigastric perforator flaps for postmastectomy breast reconstruction. This is the first case of bilateral giant phyllodes tumor in which mastectomy was followed immediately by autologous tissue reconstruction. Results Large flap reconstruction conferred adequate leverage for wide excision of giant phyllodes tumors, and no local recurrence or distal metastatic lesions were observed over a follow-up period of 4 years. Conclusions This method caused less donor site morbidity than did methods involving other types of flaps, and good functional and cosmetic results were achieved.

Abdurro’uf et al., This paper documents the seventeenth data release (DR17) from the Sloan Digital Sky Surveys; the fifth and final release from the fourth phase (SDSS-IV). DR17 contains the complete release of the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, which reached its goal of surveying over 10,000 nearby galaxies. The complete release of the MaNGA Stellar Library accompanies this data, providing observations of almost 30,000 stars through the MaNGA instrument during bright time. DR17 also contains the complete release of the Apache Point Observatory Galactic Evolution Experiment 2 survey that publicly releases infrared spectra of over 650,000 stars. The main sample from the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), as well as the subsurvey Time Domain Spectroscopic Survey data were fully released in DR16. New single-fiber optical spectroscopy released in DR17 is from the SPectroscipic IDentification of ERosita Survey subsurvey and the eBOSS-RM program. Along with the primary data sets, DR17 includes 25 new or updated value-added catalogs. This paper concludes the release of SDSS-IV survey data. SDSS continues into its fifth phase with observations already underway for the Milky Way Mapper, Local Volume Mapper, and Black Hole Mapper surveys., This publication uses data generated via the Zooniverse.org platform, development of which is funded by generous support, including a Global Impact Award from Google, and by a grant from the Alfred P. Sloan Foundation. This publication makes use of data products from the Two Micron All Sky Survey, which is a joint project of the University of Massachusetts and the Infrared Processing and Analysis Center/California Institute of Technology, funded by the National Aeronautics and Space Administration and the National Science Foundation. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC; https://www.cosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement.

BACKGROUND This study is a retrospective review to compare combining progressive tension sutures, closed drain, and fibrin sealant effects on seroma formation, postoperative drainage volume, and hospital stay for abdominoplasty after deep inferior epigastric artery perforator (DIEP) flap. We ever published a 0% seroma rate in abdominoplasty after DIEP flap using progressive tension sutures and closed drain. Massive abdominal wound drainage caused delayed drain removal and increased hospital stay and medical costs. METHODS We retrospectively evaluated 54 abdominoplasty patients between December 2013 and September 2017; 43 patients used fibrin glue and 11 used progressive tension sutures and closed drain. RESULTS Abdominal drainage for the first 3 postoperative days was 84.65 ± 52.95 mL in the fibrin group, with total drainage of 127.70 ± 125.50 mL and 214.45 ± 104.35 mL in the no fibrin group, with total drainage of 350.45 ± 213.58 mL. Drains were removed on postoperative day 6.21 ± 1.44 in the fibrin group and day 9.64 ± 1.96 in the no fibrin group. The association of the first 3 days and total drainage volumes with the drain removal day significantly differed in the fibrin and no fibrin groups. Hospital stay was 9.88 ± 3.55 and 12.45 ± 5.22 days in the fibrin and no fibrin group, respectively, with borderline significant differences. CONCLUSIONS Donor site abdominoplasty after DIEP flap combining progressive tension sutures, closed drainage, and fibrin glue can prevent seroma occurrence, reduce postoperative abdominal drainage and need for blood transfusion, and achieve early removal of the abdominal drain, shorter hospital stay, and lower medical cost.

Autologous breast reconstructions using deep inferior epigastric perforator (DIEP) flaps create a large incision, presenting an opportunity for surgical site complications. In this pilot study, we aimed to examine outcomes in DIEP donor site incisions managed with standard dressings (control; n = 5) or closed incision negative pressure therapy (ciNPT; n = 5). We observed no significant differences between group age, body mass index, and past medical history. Both treatment groups had a similar duration of hospital stay, the number of blood transfusions, and pain scores on postoperative day 2 (P > .05). There was a trend of higher drainage (P = .251) and shorter time to incision healing (P = .067) in the ciNPT group than the control though the difference was not statistically significant. We did observe a significant improvement in scar pigmentation, vascularity, and pliability at 3, 6, and 12 months post‐surgery in the ciNPT group compared with control (P

We report a rare case that after rapid recurrence there was pathological transition from a fibroadenoma and benign phyllodes tumor to borderline and malignant phyllodes tumor. Another rare finding included tumor dissemination in the pleural cavity via reconstructed deep inferior epigastric perforator flap edge and internal mammary vessel bundle. Hence, we eliminated the use of internal mammary vessel bundle as the recipient vessel for free-flap reconstruction to avoid recurrence in the pleural cavity. Remarkably, we achieved successful reconstruction of 2 huge defects (reconstruction of breast following mastectomy and that of chest wall following en bloc excision of recurrence) using 2 different free flaps.

Drowsiness of driver is one of the common causes resulting in road crashes. According to the research, there have been twenty percent of the road accidents which are related to the drowsiness of drivers. Nowadays, with the development technology, various approaches are introduced to detect the drowsiness of drivers. In this paper, we propose a multi-model fusion system which is composed of the three models to capture driver’s face and detect drowsiness in the real-time for telemetric robotics tracking applications. The sensor device we used is an RGB camera which is mounted in front of driver to obtain the facial image. Then, we combine the results based on the state of the eye blink, yawn and head deviation to determine whether the driver is drowsy. We test our models to obtain the weighting factors in drowsy value. In the experiment, we show that our system has the high accuracy of detection.

The objective of this paper is to develop a modular Robot Operating System (ROS) based autonomous mobile industrial robot system for automated intelligent manufacturing applications. We propose a finite state machine based method to integrate and manage various modular functions on the mobile manipulator which makes it have a great talent on mobility and manipulation. For mobility, we perform simultaneous localization and mapping (SLAM) on our robot to build a map and locate itself. We also develop navigation and collision avoidance strategies, so that it can navigate to anywhere it plans in the indoor environment. For manipulation, we use an RGB-D camera on the end effector to perform eye-in-hand system which given an image and point cloud, leveraging the learning-based object detection and shape-based grasping pose estimation to achieve flexible manipulation capabilities. In the experiments, we have developed an Autonomous Mobile Industrial Robot (AMIR) with a carefully designed mechanism and a fully modular ROS environment in our robotics lab at NTU. In the experiments, we construct an intelligent industrial scenario: collecting materials and delivering products from one place to another. Using our ROS based architecture to control the data/command flow between functions, we have successfully completed the demonstration of the system and proved the stability of the system.

Fucoidan, a natural sulfated polysaccharide, which can activate the immune response and lessen adverse effects, is expected to be an adjuvant agent in combination with chemotherapy. Using natural hydrophilic anticancer polysaccharides to simultaneously encapsulate hydrophobic anticancer drugs is feasible, and a reduced side effect can be achieved to amplify the therapeutic efficacy. In this study, a novel type of fucoidan-PLGA nanocarrier (FPN-DTX) was developed for the encapsulation of the hydrophobic anticancer drug, docetaxel (DTX), as a drug delivery system. From the comparison between FPN-DTX and the PLGA particles without fucoidan (PLGA-DTX), FPNs&ndash, DTX with fucoidan were highly stable with smaller sizes and dispersed well without aggregations in an aqueous environment. The drug loading and release can be further modified by modulating relative ratios of Fucoidan (Fu) to PLGA. The (FPN 3-DTX) nanoparticles with a 10:3 ratio of Fu:PLGA displayed uniform particle size with higher encapsulation efficiency than PLGA NPs and sustained drug release ability. The biocompatible fucoidan-PLGA nanoparticles displayed low cytotoxicity without drug loading after incubation with MDA-MB-231 triple-negative breast cancer cells. Despite lower cellular uptake than that of PLGA-DTX due to a higher degree of negative zeta potential and hydrophilicity, FPN 3-DTX effectively exerted better anticancer ability, so FPN 3-DTX can serve as a competent drug delivery system.

We utilize the Hyper Suprime-Cam (HSC) Wide Survey to explore the properties of galaxies located in the voids identified from the Baryon Oscillation Spectroscopic Survey (BOSS) up to z~0.7. The HSC reaches i~25, allowing us to characterize the void galaxies down to 10$^{9.2}$ solar mass. We find that the revised void galaxy densities, when including faint galaxies in voids defined by bright galaxies, are still underdense compared to the mean density from the entire field. In addition, we classify galaxies into star-forming, quiescent, and green valley populations, and find that void galaxies tend to have slightly higher fractions of star-forming galaxies under the mass and redshift control, although the significance of this result is only moderate (2$\sigma$). However, when we focus on the star-forming population, the distribution of the specific star formation rate (sSFR) of void galaxies shows little difference from that of the control galaxies. Similarly, the median sSFR of star-forming void galaxies is also in good agreement with that of the star-forming control galaxies. Moreover, the effective green valley fraction of void galaxies, defined as the number of green valley galaxies over the number of nonquiescent galaxies, is comparable to that of the control ones, supporting the suggestion that void and control galaxies evolve under similar physical processes and quenching frequencies. Our results thus favor a scenario of the galaxy assembly bias., Comment: 17 pages, 10 figures, 3 tables, ApJ accepted

For oral anti-cancer drug delivery, a new chitosan-lipid nanoparticle with sodium dodecyl sulfate modification was designed and synthesized using a double emulsification. TEM examination showed that the DOX-loaded nanoparticles, termed D-PL/TG NPs, exhibited a unique core-shell configuration composed of multiple amphiphilic chitosan-lecithin reverse micelles as the core and a triglyceride shell as a physical barrier to improve the encapsulation efficiency and reduce the drug leakage. In addition, the D-PL/TG NPs with sodium dodecyl sulfate modification on the surface have enhanced stability in the GI tract and increased oral bioavailability of doxorubicin. In vitro transport studies performed on Caco-2 monolayers indicated that the D-PL/TG NPs enhanced the permeability of DOX in the Caco-2 monolayers by altering the transport pathway from passive diffusion to transcytosis. The in vivo intestinal absorption assay suggested that the D-PL/TG NPs were preferentially absorbed through the specialized membranous epithelial cells (M cells) of the Peyer's patches, resulting in a significant improvement (8-fold) in oral bioavailability compared to that of free DOX. The experimental outcomes in this work demonstrate that the D-PL/TG NPs provide an exciting opportunity for advances in the oral administration of drugs with poor bioavailability that are usually used in treating tough and chronic diseases.

Facebook was applied to investigate correlation between psychological symptoms.Belief in dangerous virtual community is correlated to social anxiety.Increase in social anxiety increases the continuance intention.Increase in general social anxiety increases the online social anxiety. Despite increased understanding regarding the effects of individual and contextual factors on continuance intention, this study investigated individuals' beliefs in dangerous virtual communities as a predictor of the related psychological symptoms, general and online social anxiety, in relation to individuals' continuance intention to sustain participation in the social network of Facebook. Confirmatory factor analysis was applied to 230 effective questionnaires and the results revealed that belief in dangerous virtual communities was positively correlated to both general and online social anxiety, which results in a negative correlation with continuance intention. The implication was that if participants experienced high levels of both types of social anxieties, then they exhibited a low level of continuance intention. In conjunction with a number of studies, the findings suggested that belief in a dangerous virtual community serves as the antecedent of general and online social anxiety. In addition, recommendations for future research are provided by the study.

In this study, we investigate the device performance of bulk heterojunction (BHJ) polymer solar cells (PSCs) fabricated from pristine chlorobenzene (CB) solution, CB solutions with different concentrations of solvent processing additive, chloronaphthalene (CN) which has a high boiling point temperature, and pristine CN solution. An efficiency of 7.12% is observed from PSCs processed from pristine CN solution as compared with 4.01% of that from pristine CB solution. The correlation between the efficiency of PSCs with the concentrations of CN was systematically studied by absorption spectra, atomic force microscopy and cross-section transmission electron microscopy images, wide angle X-ray diffraction and grazing incidence small angle X-ray patterns of BHJ active layers and impedance spectroscopies of BHJ PSCs. It was found that the addition of CN into CB solution does not affect the crystallization or the molecular packing of the donor polymer in BHJ layers, but it changes the film morphology of the BHJ layers. The phase separation between the donor polymer and fullerene derivatives was reduced and BHJ layers were redistributed as the concentration of CN is increased in CB solutions. As a result, increased ratios of the donor polymer to fullerene derivatives, and high hole mobilities of the donor polymer in BHJ layers were obtained for the resultant films. Consequently, a high efficiency was observed from PSCs processed from CN solution rather than from CB solution. Our findings provide a method to approach highly efficient PSCs.

We study the role of cold gas in quenching star formation in the green valley by analyzing ALMA 12 CO (1-0) observations of three galaxies with resolved optical spectroscopy from the MaNGA survey. We present resolution-matched maps of the star formation rate and molecular gas mass. These data are used to calculate the star formation efficiency (SFE) and gas fraction (f gas ) for these galaxies separately in the central "bulge" regions and outer disks. We find that, for the two galaxies whose global specific star formation rate (sSFR) deviates most from the star formation main sequence, the gas fraction in the bulges is significantly lower than that in their disks, supporting an "inside-out" model of galaxy quenching. For the two galaxies where SFE can be reliably determined in the central regions, the bulges and disks share similar SFEs. This suggests that a decline in f gas is the main driver of lowered sSFR in bulges compared to disks in green valley galaxies. Within the disks, there exist common correlations between the sSFR and SFE and between sSFR and f gas on kiloparsec scales - the local SFE or f gas in the disks declines with local sSFR. Our results support a picture in which the sSFR in bulges is primarily controlled by f gas , whereas both SFE and f gas play a role in lowering the sSFR in disks. A larger sample is required to confirm if the trend established in this work is representative of the green valley as a whole., The work is supported by the Ministry of Science & Technology of Taiwan under the grant MOST 103-2112-M-001-031-MY3 and 106-2112-M-001-034. R.M. and F.B. acknowledge support by the UK Science and Technology Facilities Council (STFC). R.M. acknowledges ERC Advanced Grant 695671 "QUENCH."

Background First rib fractures and traumatic Horner's syndrome are both quite rare, which can make it difficult to properly diagnose the combination of these 2 conditions in the emergency department. These conditions may be associated with severe medical emergencies, such as ongoing carotid dissection. Case Report We present the case of a 33-year-old man who sustained fractures to his right second, third, and fourth ribs and a delay in the diagnosis of left Horner's syndrome after he was involved in a traffic accident. Left Horner's syndrome was caused by a left transverse fracture of the first rib. This fracture was not detected on chest radiographs and required a 3-dimensional reconstructed neck computed tomography scan for detection. Why Should an Emergency Physician Be Aware of This? In the diagnosis of carotid artery dissection, conventional angiography is the criterion standard but is considered invasive. CTA is less invasive, time-saving, and can show more anatomic structures in the neck in addition to the carotid arteries. It is a good screening diagnostic modality in the traumatology department. Although the treatments for Horner's syndrome and first rib fracture are conservative, the early diagnosis of both conditions can resolve the anxiety and uncertainty experienced by both doctors and patients.

Introduction: Breast reconstruction using silicone implants is a widespread choice, however, breast capsular contracture (BCC), a response of the immune system to foreign materials, is the most affliction and frustration fibrosis complications after silicone implantation. Chronic inflammation-associated fibrosis is regarded as a main cause of BCC. Hyaluronic acid (HA) is an effective anti-adhesive and anti-fibrotic agent. Furthermore, 1,4-butanediol diglycidyl ether-cross-linked hyaluronan hydrogel (cHA) is a non-resorbable cross-linked hyaluronan-derived polymer with no cytotoxicity and high stability. This study aims to evaluate the potential of cHA on preventing BCC in breast surgery using silicone implants. Methods: The effect of cHA on BCC will be examined in breast BCC rat model. Results: Our study showed that cHA decreased fibrosis-regulated factors transforming growth factor beta 1 (TGF-β1) and tissue inhibitor of metalloproteinase (TIMP) expressions and increased metalloproteinase (MMP) MMP-9 expression in capsule tissue. cHA significantly decreased inflammatory mediators tumor necrosis factoralpha (TNF-α), interleukin IL-6, nitric oxide (NO), as well as inducible nitric oxide synthase (iNOS) expressions. In addition, cHA significantly decreased transcription factor nuclear factor kappa B (NF-κB) activation in silicone surrounded tissue. Conclusions: cHA showed prevention in BCC formation through inhibiting NF-κB -associated inflammation in rats with silicone implantation.

Phyllodes tumors of the breast are the rarest of all breast neoplasms. Giant phyllodes tumors (>10 cm) of the breast have been less discussed in the literature. Reconstruction of the large defect created after wide excision (safety margin >1 cm) is a challenge in these patients. We present one technique using a bi-pedicled deep inferior epigastric perforator flap for post-mastectomy breast reconstruction for giant phyllodes tumors. We treated three patients with giant phyllodes tumors between 2013 and 2016. The histological characteristics were benign and borderline; tumor sizes were 18 × 13 × 12, 20 × 16 × 9.5, and 18 × 15 × 9 cm. Immediate post-mastectomy reconstruction was performed using bi-pedicled deep inferior epigastric perforator flaps. Flap sizes measured 30 × 11, 28 × 12, and 28 × 13 cm. Total operative time, including that for mastectomy, was 285, 425, and 410 min. The duration of hospital stay was 12, 13, and 9 days. No local recurrence or distant metastasis occurred in the first two patients over a follow-up period of 3 years and in the third patient over a follow-up period of 6 months. A higher local recurrence rate was associated with positive margins, histological grade, tumor size, and necrosis. Immediate post-mastectomy breast reconstruction may become the preferred option for treatment of giant phyllodes tumors. A bi-pedicled deep inferior epigastric perforator flap conferred adequate leverage for wide excision and resolved scar contracture of the axilla. Good functional and cosmetic results were achieved. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

For oral anti-cancer drug delivery, a new chitosan-lipid nanoparticle with sodium dodecyl sulfate modification was designed and synthesized using a double emulsification. TEM examination showed that the DOX-loaded nanoparticles, termed D-PL/TG NPs, exhibited a unique core-shell configuration composed of multiple amphiphilic chitosan-lecithin reverse micelles as the core and a triglyceride shell as a physical barrier to improve the encapsulation efficiency and reduce the drug leakage. In addition, the D-PL/TG NPs with sodium dodecyl sulfate modification on the surface have enhanced stability in the GI tract and increased oral bioavailability of doxorubicin. In vitro transport studies performed on Caco-2 monolayers indicated that the D-PL/TG NPs enhanced the permeability of DOX in the Caco-2 monolayers by altering the transport pathway from passive diffusion to transcytosis. The in vivo intestinal absorption assay suggested that the D-PL/TG NPs were preferentially absorbed through the specialized membranous epithelial cells (M cells) of the Peyer's patches, resulting in a significant improvement (8-fold) in oral bioavailability compared to that of free DOX. The experimental outcomes in this work demonstrate that the D-PL/TG NPs provide an exciting opportunity for advances in the oral administration of drugs with poor bioavailability that are usually used in treating tough and chronic diseases.

Unlike 7-azaindole consisting of the tetrameric configuration, 3-methyl-7-azaindole (3MAI) exists solely as intact double hydrogen-bonded dimeric forms in a single crystal. Both steady-state and time-resolved measurements down to 8.0 K reveal remarkable deuterium isotope effects on the rate of excited-state double proton transfer (ESDPT) in the N(1)-deuterated 3MAI (3MAI-d) single crystal. The rates of ESDPT for the 3MAI-d dimer resolved at

We present our study on the spatially resolved H_alpha and M_star relation for 536 star-forming and 424 quiescent galaxies taken from the MaNGA survey. We show that the star formation rate surface density (Sigma_SFR), derived based on the H_alpha emissions, is strongly correlated with the M_star surface density (Sigma_star) on kpc scales for star- forming galaxies and can be directly connected to the global star-forming sequence. This suggests that the global main sequence may be a consequence of a more fundamental relation on small scales. On the other hand, our result suggests that about 20% of quiescent galaxies in our sample still have star formation activities in the outer region with lower SSFR than typical star-forming galaxies. Meanwhile, we also find a tight correlation between Sigma_H_alpha and Sigma_star for LI(N)ER regions, named the resolved "LI(N)ER" sequence, in quiescent galaxies, which is consistent with the scenario that LI(N)ER emissions are primarily powered by the hot, evolved stars as suggested in the literature., Comment: 6 pages, 4 figures. ApJ Letter accepted

This study explores the antecedents and outcomes of in dividual perceived safety in life. After factoring out beliefs and social anxiety, Facebook use was selected as a predictor for related psychological symptoms. A confirmatory factor analysis was applied to 230 email validated samples. Structural equation modeling was used to test the predictions for each construct. The results show that Psychological need of safety was positively correlated to both social anxieties and positively reflected to beliefs in dangerous online communities. The implication is that if the participants have high level of both social anxieties, then they have high levels of belief in dangerous online communities. The implication of these findings in conjunction with a number of discussions and recommendations for future research are provided. Keywords-general social anxiety; online social anxiety; psychological needs for safety; belief in a dangerous online community

The difference in gender is often affected by the politics and the environment. A number of recent researches try to explore the impact of gender difference. As the internet becomes popularized, the way people learn is changed; many now learn through the internet. The present study unveiled the different types of video guitar learning lessons’influence on impulsive behavior, instrument learning self-efficacy, applicability, learning interest and user satisfaction. Online surveys were distributed through a guitar learning website, and a data of 177 containing 75 males and 42 females was obtained. Previous researches show that females have an overall higher satisfaction and learning interest than males.However, the results of the present study showed that there was no gender difference in impulsive behavior, instrument learning self-efficacy and applicability when learning through video guitar learning lessons. In addition, the male user satisfaction and learning interest were significantly higher than that of the female. Keywords-gender difference; self-efficacy; impulsive behavior; learning interest; user satisfaction

A DOX-loaded polysaccharide-lecithin reverse micelles triglyceride-based oral delivery nanocarrier (D-PL/TG NPs) conjugated with (i) RGD peptide for targeting to β1 integrin of M cells and (ii) Lyp-1 peptide for targeting to the p32 receptor of MDA-MB-231 cells is used to investigate the multistage continuous targeting capabilities of these peptide-conjugated nanocarriers (GLD-PL/TG NPs) for tumor therapy. Variations in the targeting efficacy and pharmacokinetic properties are investigated by quantitatively controlling the surface density of different peptides on the nanoparticles. In vitro permeability in a human follicle-associated epithelium model and cytotoxicity against MDA-MB-231 cells indicate that the nanocarriers conjugated with high RGD peptide concentrations display a higher permeability due to the existence of M cells with higher transcytosis activity, but a higher concentration of conjugated Lyp-1 peptide exhibits the lowest cell viability. Being benefited from specific targeting of peptide conjugation, improved bioavailability and enhanced tumor accumulation are achieved by the GLD-PL/TG NPs, leading to better antitumor efficacy. The results of in vivo biodistribution and antitumor studies reveal that the effect of LyP-1 peptide is more predominant than that of RGD peptide. This proof of multistage continuous targeting may open the door to a new generation of oral drug delivery systems in targeted cancer therapy.

This paper proposes a region-based color correction method that corrects color-shifted images based on a reference image with a standard background. When correcting images without foreground objects, i.e., objects not in the reference image, both the reference image and the color-shifted image are segmented into several regions. A color correction process based on principal component analysis (PCA) is performed between the corresponding regions on the reference image and color-shifted image. The key concept of the color correction process is to align the color distribution of regions on the color-shifted image with the corresponding ones on the reference image by an Affine transform. The proposed color correction is also applicable to those images with foreground objects. In the experiments, the effectiveness of the proposed method is verified by testing some simple images and real-world images with and without foreground objects. Particularly, the proposed method effectively improves the skin-color area identification in a face detector, which is an important issue in many computer vision applications

A molecular recognition concept exploiting multiple-hydrogen-bond fine-tuned excited-state proton-transfer (ESPT) was conveyed using 3,4,5,6-tetrahydrobis(pyrido[3,2-g]indolo)[2,3-a:3',2'-j]acridine (1a). The catalytic type 1a/carboxylic acids hydrogen-bonding (HB) complexes undergo ultrafast ESPT, resulting in an anomalously large Stokes shifted tautomer emission (lambdamax approximately 600 nm). Albeit forming a quadruple HB complex, ESPT is prohibited in the noncatalytic-type 1a/urea complexes (lambdamax approximately 430 nm). The HB configuration tuning ESPT properties lead to a feasible design for sensing multiple-HB-site analytes of biological interest.