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27 results on '"Chianese, Salvatore"'

1. Access-Site Crossover in Patients With Acute Coronary Syndrome Undergoing Invasive Management

Author

Gragnano, Felice, Branca, Mattia, Frigoli, Enrico, Leonardi, Sergio, Vranckx, Pascal, Di Maio, Dario, Monda, Emanuele, Fimiani, Luigi, Fioretti, Vincenzo, Chianese, Salvatore, Esposito, Fabrizio, Franzese, Michele, Scalise, Martina, D’Angelo, Claudio, Scalise, Renato, De Blasi, Gabriele, Andò, Giuseppe, Esposito, Giovanni, Calabrò, Paolo, Windecker, Stephan, Pedrazzini, Giovanni, and Valgimigli, Marco

Published
2021
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2. Prognostic Implications of Declining Hemoglobin Content in Patients Hospitalized With Acute Coronary Syndromes

Author

Leonardi, Sergio, Gragnano, Felice, Carrara, Greta, Gargiulo, Giuseppe, Frigoli, Enrico, Vranckx, Pascal, Di Maio, Dario, Spedicato, Vanessa, Monda, Emanuele, Fimiani, Luigi, Fioretti, Vincenzo, Esposito, Fabrizio, Avvedimento, Marisa, Magliulo, Fabio, Leone, Attilio, Chianese, Salvatore, Franzese, Michele, Scalise, Martina, Schiavo, Alessandra, Mazzone, Paolo, Esposito, Giovanni, Andò, Giuseppe, Calabrò, Paolo, Windecker, Stephan, and Valgimigli, Marco

Published
2021
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5. Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment

Author

Mauro, Ciro, primary, Capone, Valentina, additional, Cocchia, Rosangela, additional, Cademartiri, Filippo, additional, Riccardi, Ferdinando, additional, Arcopinto, Michele, additional, Alshahid, Maie, additional, Anwar, Kashif, additional, Carafa, Mariano, additional, Carbone, Andreina, additional, Castaldo, Rossana, additional, Chianese, Salvatore, additional, Crisci, Giulia, additional, D’Assante, Roberta, additional, De Luca, Mariarosaria, additional, Franzese, Monica, additional, Galzerano, Domenico, additional, Maffei, Vincenzo, additional, Marra, Alberto M., additional, Valente, Valeria, additional, Giardino, Federica, additional, Mazza, Alfredo, additional, Ranieri, Brigida, additional, D’Agostino, Anna, additional, Rega, Salvatore, additional, Romano, Luigia, additional, Scagliarini, Sarah, additional, Sepe, Chiara, additional, Vriz, Olga, additional, Izzo, Raffaele, additional, Cittadini, Antonio, additional, Bossone, Eduardo, additional, and Salzano, Andrea, additional

Published
2023
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6. Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways

Author

Mauro, Ciro, primary, Capone, Valentina, additional, Cocchia, Rosangela, additional, Cademartiri, Filippo, additional, Riccardi, Ferdinando, additional, Arcopinto, Michele, additional, Alshahid, Maie, additional, Anwar, Kashif, additional, Carafa, Mariano, additional, Carbone, Andreina, additional, Castaldo, Rossana, additional, Chianese, Salvatore, additional, Crisci, Giulia, additional, D’Assante, Roberta, additional, De Luca, Mariarosaria, additional, Franzese, Monica, additional, Galzerano, Domenico, additional, Maffei, Vincenzo, additional, Marra, Alberto Maria, additional, Mazza, Alfredo, additional, Ranieri, Brigida, additional, D’Agostino, Anna, additional, Rega, Salvatore, additional, Romano, Luigia, additional, Scagliarini, Sarah, additional, Sepe, Chiara, additional, Vriz, Olga, additional, Izzo, Raffaele, additional, Cittadini, Antonio, additional, Bossone, Eduardo, additional, and Salzano, Andrea, additional

Published
2023
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7. Acute Heart Failure: Diagnostic–Therapeutic Pathways and Preventive Strategies—A Real-World Clinician’s Guide

Author

Mauro, Ciro, primary, Chianese, Salvatore, additional, Cocchia, Rosangela, additional, Arcopinto, Michele, additional, Auciello, Stefania, additional, Capone, Valentina, additional, Carafa, Mariano, additional, Carbone, Andreina, additional, Caruso, Giuseppe, additional, Castaldo, Rossana, additional, Citro, Rodolfo, additional, Crisci, Giulia, additional, D’Andrea, Antonello, additional, D’Assante, Roberta, additional, D’Avino, Maria, additional, Ferrara, Francesco, additional, Frangiosa, Antonio, additional, Galzerano, Domenico, additional, Maffei, Vincenzo, additional, Marra, Alberto Maria, additional, Mehta, Rahul M., additional, Mehta, Rajendra H., additional, Paladino, Fiorella, additional, Ranieri, Brigida, additional, Franzese, Monica, additional, Limongelli, Giuseppe, additional, Rega, Salvatore, additional, Romano, Luigia, additional, Salzano, Andrea, additional, Sepe, Chiara, additional, Vriz, Olga, additional, Izzo, Raffaele, additional, Cademartiri, Filippo, additional, Cittadini, Antonio, additional, and Bossone, Eduardo, additional

Published
2023
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10. Severe Stenosis of Mitral Bioprosthetic Valve Thrombosis in a Patient with HCV-Related Cirrhosis and Duodenal Variceal Bleeding: The Deadly Triad

Author

Cocchia, Rosangela, primary, Chianese, Salvatore, additional, Lombardi, Giovanni, additional, Romano, Luigia, additional, Capone, Valentina, additional, Amitrano, Lucio, additional, Bennato, Raffaele, additional, Ranieri, Brigida, additional, Russo, Giuseppe, additional, Mauro, Ciro, additional, and Bossone, Eduardo, additional

Published
2022
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11. Effects of Exercise on Heart Failure with Preserved Ejection Fraction: An Updated Review of Literature

Author

Crisci, Giulia, primary, De Luca, Mariarosaria, additional, D’Assante, Roberta, additional, Ranieri, Brigida, additional, D’Agostino, Anna, additional, Valente, Valeria, additional, Giardino, Federica, additional, Capone, Valentina, additional, Chianese, Salvatore, additional, Rega, Salvatore, additional, Cocchia, Rosangela, additional, Israr, Muhammad Zubair, additional, Debiek, Radek, additional, Heaney, Liam M., additional, and Salzano, Andrea, additional

Published
2022
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12. Physiologic Range of Myocardial Mechano-Energetic Efficiency among Healthy Subjects: Impact of Gender and Age

Author

Ferrara, Francesco, primary, Capone, Valentina, additional, Cademartiri, Filippo, additional, Vriz, Olga, additional, Cocchia, Rosangela, additional, Ranieri, Brigida, additional, Franzese, Monica, additional, Castaldo, Rossana, additional, D’Andrea, Antonello, additional, Citro, Rodolfo, additional, Chianese, Salvatore, additional, Annunziata, Roberto, additional, Marullo, Flavio, additional, Siniscalchi, Mario, additional, Conte, Marianna, additional, Sepe, Chiara, additional, Maramaldi, Renato, additional, Rega, Salvatore, additional, Russo, Giuseppe, additional, Majolo, Massimo, additional, Raiola, Eliana, additional, Salzano, Andrea, additional, Mauro, Ciro, additional, Trimarco, Bruno, additional, Izzo, Raffaele, additional, and Bossone, Eduardo, additional

Published
2022
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13. Right Heart Pulmonary Circulation Unit Response to Exercise in Patients with Controlled Systemic Arterial Hypertension: Insights from the RIGHT Heart International NETwork (RIGHT-NET)

Author

Vriz, Olga, primary, Palatini, Paolo, additional, Rudski, Lawrence, additional, Frumento, Paolo, additional, Kasprzak, Jarosław D., additional, Ferrara, Francesco, additional, Cocchia, Rosangela, additional, Gargani, Luna, additional, Wierzbowska-Drabik, Karina, additional, Capone, Valentina, additional, Ranieri, Brigida, additional, Salzano, Andrea, additional, Stanziola, Anna Agnese, additional, Marra, Alberto Maria, additional, Annunziata, Roberto, additional, Chianese, Salvatore, additional, Rega, Salvatore, additional, Saltalamacchia, Teresa, additional, Maramaldi, Renato, additional, Sepe, Chiara, additional, Limongelli, Giuseppe, additional, Cademartiri, Filippo, additional, D’Andrea, Antonello, additional, D’Alto, Michele, additional, Izzo, Raffaele, additional, Ferrara, Nicola, additional, Mauro, Ciro, additional, Cittadini, Antonio, additional, Ekkehard, Grünig, additional, Guazzi, Marco, additional, and Bossone, Eduardo, additional

Published
2022
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14. Reference Ranges of Left Ventricular Hemodynamic Forces in Healthy Adults: A Speckle-Tracking Echocardiographic Study

Author

Ferrara, Francesco, primary, Capuano, Francesco, additional, Cocchia, Rosangela, additional, Ranieri, Brigida, additional, Contaldi, Carla, additional, Lacava, Graziella, additional, Capone, Valentina, additional, Chianese, Salvatore, additional, Rega, Salvatore, additional, Annunziata, Roberto, additional, Sepe, Chiara, additional, Salzano, Andrea, additional, Citro, Rodolfo, additional, D’Andrea, Antonello, additional, Mauro, Ciro, additional, Cademartiri, Filippo, additional, Pedrizzetti, Gianni, additional, and Bossone, Eduardo, additional

Published
2021
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15. Prediction of radial crossover in acute coronary syndromes: derivation and validation of the MATRIX score

Author

Gragnano, Felice, primary, Jolly, Sanjit S., additional, Mehta, Shamir R., additional, Branca, Mattia, additional, van Klaveren, David, additional, Frigoli, Enrico, additional, Gargiulo, Giuseppe, additional, Leonardi, Sergio, additional, Vranckx, Pascal, additional, Di Maio, Dario, additional, Monda, Emanuele, additional, Fimiani, Luigi, additional, Fioretti, Vincenzo, additional, Chianese, Salvatore, additional, Andò, Giuseppe, additional, Esposito, Giovanni, additional, Sangiorgi, Giuseppe Massimo, additional, Biondi-Zoccai, Giuseppe, additional, Heg, Dik, additional, Calabrò, Paolo, additional, Windecker, Stephan, additional, Romagnoli, Enrico, additional, and Valgimigli, Marco, additional

Published
2021
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16. Preoperative Assessment and Management of Cardiovascular Risk in Patients Undergoing Non-Cardiac Surgery: Implementing a Systematic Stepwise Approach during the COVID-19 Pandemic Era

Author

Bossone, Eduardo, primary, Cademartiri, Filippo, additional, AlSergani, Hani, additional, Chianese, Salvatore, additional, Mehta, Rahul, additional, Capone, Valentina, additional, Ruotolo, Carlo, additional, Tarrar, Imran Hayat, additional, Frangiosa, Antonio, additional, Vriz, Olga, additional, Maffei, Vincenzo, additional, Annunziata, Roberto, additional, Galzerano, Domenico, additional, Ranieri, Brigida, additional, Sepe, Chiara, additional, Salzano, Andrea, additional, Cocchia, Rosangela, additional, Majolo, Massimo, additional, Russo, Giuseppe, additional, Longo, Giuseppe, additional, Muto, Mario, additional, Fedelini, Paolo, additional, Esposito, Ciro, additional, Perrella, Alessandro, additional, Guggino, Gianluca, additional, Raiola, Eliana, additional, Catalano, Mara, additional, De Palma, Maurizio, additional, Romano, Luigia, additional, Romano, Gaetano, additional, Coppola, Ciro, additional, Mauro, Ciro, additional, and Mehta, Rajendra H., additional

Published
2021
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17. Successful surgical repair of left ventricular pseudoaneurysm in a patient with subacute ST-elevation myocardial infarction

Author

Cocchia, Rosangela, primary, Iannelli, Gabriele, additional, Capone, Valentina, additional, Chianese, Salvatore, additional, Langella, Giuseppina, additional, Ranieri, Brigida, additional, Majolo, Massimo, additional, Russo, Giuseppe, additional, Pilato, Emanuele, additional, Mauro, Ciro, additional, and Bossone, Eduardo, additional

Published
2021
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18. Predictors of adherence to composite therapy after acute coronary syndromes

Author

Stabile, Eugenio, primary, Franzese, Michele, additional, Chianese, Salvatore, additional, Alfani, Arturo, additional, Gerardi, Donato, additional, Colaiori, Iginio, additional, Annunziata, Monica, additional, Nappi, Pierluigi, additional, Scalise, Martina, additional, Di Serafino, Luigi, additional, Puzone, Brunella, additional, Avvedimento, Marisa, additional, Leone, Attilio, additional, Ilardi, Federica, additional, Piccolo, Raffaele, additional, Franzone, Anna, additional, Cirillo, Plinio, additional, Morisco, Carmine, additional, Trimarco, Bruno, additional, and Esposito, Giovanni, additional

Published
2021
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19. Cardiac teleconsulting in the time of COVID-19 global pandemic: The “Antonio Cardarelli” Hospital project

Author

Bossone, Eduardo, primary, Mauro, Ciro, additional, Maiellaro, Alfonso, additional, Raiola, Eliana, additional, Cocchia, Rosangela, additional, Ranieri, Brigida, additional, Sepe, Chiara, additional, Capone, Valentina, additional, Chianese, Salvatore, additional, Maramaldi, Renato, additional, Acerra, Enrico Pasquale, additional, Mirto, Gaetano, additional, Lodato, Sergio, additional, Russo, Giuseppe, additional, and Longo, Giuseppe, additional

Published
2021
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20. ECG analysis in patients with acute coronary syndrome undergoing invasive management: rationale and design of the electrocardiography sub-study of the MATRIX trial

Author

Gragnano, Felice, primary, Spedicato, Vanessa, additional, Frigoli, Enrico, additional, Gargiulo, Giuseppe, additional, Di Maio, Dario, additional, Fimiani, Fabio, additional, Fioretti, Vincenzo, additional, Annoiato, Claudia, additional, Cimmino, Michele, additional, Esposito, Fabrizio, additional, Chianese, Salvatore, additional, Scalise, Martina, additional, Fimiani, Luigi, additional, Franzese, Michele, additional, Monda, Emanuele, additional, Schiavo, Alessandra, additional, Cesaro, Arturo, additional, De Michele, Alfonso, additional, Scalise, Renato, additional, Caracciolo, Alessandro, additional, Andò, Giuseppe, additional, Stabile, Eugenio, additional, Windecker, Stephan, additional, Calabrò, Paolo, additional, and Valgimigli, Marco, additional

Published
2019
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21. Successful surgical repair of left ventricular pseudoaneurysm in a patient with subacute ST-elevation myocardial infarction.

Author

Cocchia, Rosangela, Iannelli, Gabriele, Capone, Valentina, Chianese, Salvatore, Langella, Giuseppina, Ranieri, Brigida, Majolo, Massimo, Russo, Giuseppe, Pilato, Emanuele, Mauro, Ciro, and Bossone, Eduardo

Subjects
ST elevation myocardial infarction, FALSE aneurysms, SUBACUTE care
Abstract

We report a successful surgical repair of left ventricular pseudoaneurysm in a patient with subacute ST-elevation myocardial infarction (STEMI). In the case of expansion of the infarct related ventricular wall, early (within 24 hours) or late (3-5 days after STEMI) cardiac rupture should be always borne in mind in order to proceed to life saving prompt surgical repair. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment

Author

Ciro Mauro, Valentina Capone, Rosangela Cocchia, Filippo Cademartiri, Ferdinando Riccardi, Michele Arcopinto, Maie Alshahid, Kashif Anwar, Mariano Carafa, Andreina Carbone, Rossana Castaldo, Salvatore Chianese, Giulia Crisci, Roberta D’Assante, Mariarosaria De Luca, Monica Franzese, Domenico Galzerano, Vincenzo Maffei, Alberto M. Marra, Valeria Valente, Federica Giardino, Alfredo Mazza, Brigida Ranieri, Anna D’Agostino, Salvatore Rega, Luigia Romano, Sarah Scagliarini, Chiara Sepe, Olga Vriz, Raffaele Izzo, Antonio Cittadini, Eduardo Bossone, Andrea Salzano, Mauro, Ciro, Capone, Valentina, Cocchia, Rosangela, Cademartiri, Filippo, Riccardi, Ferdinando, Arcopinto, Michele, Alshahid, Maie, Anwar, Kashif, Carafa, Mariano, Carbone, Andreina, Castaldo, Rossana, Chianese, Salvatore, Crisci, Giulia, D'Assante, Roberta, De Luca, Mariarosaria, Franzese, Monica, Galzerano, Domenico, Maffei, Vincenzo, Marra, Alberto M, Valente, Valeria, Giardino, Federica, Mazza, Alfredo, Ranieri, Brigida, D'Agostino, Anna, Rega, Salvatore, Romano, Luigia, Scagliarini, Sarah, Sepe, Chiara, Vriz, Olga, Izzo, Raffaele, Cittadini, Antonio, Bossone, Eduardo, and Salzano, Andrea

Subjects
breast cancer, cardio-oncology, prevention, cardiotoxicity, General Medicine
Abstract

Cardiovascular (CV) diseases (CVD) are a major cause of long-term morbidity and mortality affecting life expectancy amongst cancer survivors. In recent years, because of the possibility of early diagnosis and the increased efficacy of neo-adjuvant and adjuvant systemic treatments (targeting specific molecular pathways), the high percentage of survival from breast cancer led CVD to become the first cause of death among survivors. Therefore, it is mandatory to adopt cardioprotective strategies to minimize CV side effects and CVD in general in breast cancer patients. Cancer therapeutics-related cardiac dysfunction (CTRCD) is a common group of side effects of chemotherapeutics widely employed in breast cancer (e.g., anthracycline and human epidermal growth factor receptor 2 inhibitors). The aim of the present manuscript is to propose a pragmatic multidisciplinary stepwise approach for prevention, early detection, and treatment of cardiotoxicity in patients with breast cancer.

Published
2023

23. Acute Heart Failure: Diagnostic-Therapeutic Pathways and Preventive Strategies-A Real-World Clinician's Guide

Author

Ciro Mauro, Salvatore Chianese, Rosangela Cocchia, Michele Arcopinto, Stefania Auciello, Valentina Capone, Mariano Carafa, Andreina Carbone, Giuseppe Caruso, Rossana Castaldo, Rodolfo Citro, Giulia Crisci, Antonello D’Andrea, Roberta D’Assante, Maria D’Avino, Francesco Ferrara, Antonio Frangiosa, Domenico Galzerano, Vincenzo Maffei, Alberto Maria Marra, Rahul M. Mehta, Rajendra H. Mehta, Fiorella Paladino, Brigida Ranieri, Monica Franzese, Giuseppe Limongelli, Salvatore Rega, Luigia Romano, Andrea Salzano, Chiara Sepe, Olga Vriz, Raffaele Izzo, Filippo Cademartiri, Antonio Cittadini, Eduardo Bossone, Mauro, Ciro, Chianese, Salvatore, Cocchia, Rosangela, Arcopinto, Michele, Auciello, Stefania, Capone, Valentina, Carafa, Mariano, Carbone, Andreina, Caruso, Giuseppe, Castaldo, Rossana, Citro, Rodolfo, Crisci, Giulia, D'Andrea, Antonello, D'Assante, Roberta, D'Avino, Maria, Ferrara, Francesco, Frangiosa, Antonio, Galzerano, Domenico, Maffei, Vincenzo, Marra, Alberto Maria, Mehta, Rahul M, Mehta, Rajendra H, Paladino, Fiorella, Ranieri, Brigida, Franzese, Monica, Limongelli, Giuseppe, Rega, Salvatore, Romano, Luigia, Salzano, Andrea, Sepe, Chiara, Vriz, Olga, Izzo, Raffaele, Cademartiri, Filippo, Cittadini, Antonio, and Bossone, Eduardo

Subjects
cardiac ultrasound, acute heart failure, computer tomography, biomarker, General Medicine, therapeutic interventions, preventive strategie
Abstract

Acute heart failure (AHF) is the most frequent cause of unplanned hospital admission in patients of >65 years of age and it is associated with significantly increased morbidity, mortality, and healthcare costs. Different AHF classification criteria have been proposed, mainly reflecting the clinical heterogeneity of the syndrome. Regardless of the underlying mechanism, peripheral and/or pulmonary congestion is present in the vast majority of cases. Furthermore, a marked reduction in cardiac output with peripheral hypoperfusion may occur in most severe cases. Diagnosis is made on the basis of signs and symptoms, laboratory, and non-invasive tests. After exclusion of reversible causes, AHF therapeutic interventions mainly consist of intravenous (IV) diuretics and/or vasodilators, tailored according to the initial hemodynamic status with the addition of inotropes/vasopressors and mechanical circulatory support if needed. The aim of this review is to discuss current concepts on the diagnosis and management of AHF in order to guide daily clinical practice and to underline the unmet needs. Preventive strategies are also discussed.

Published
2023

24. Predictors of adherence to composite therapy after acute coronary syndromes

Author

Federica Ilardi, Eugenio Stabile, Salvatore Chianese, Attilio Leone, Iginio Colaiori, Michele Franzese, Brunella Puzone, Luigi Di Serafino, Anna Franzone, Arturo Alfani, Carmine Morisco, Martina Scalise, Monica Annunziata, Giovanni Esposito, Raffaele Piccolo, Marisa Avvedimento, Plinio Cirillo, Bruno Trimarco, Donato Gerardi, Pierluigi Nappi, Stabile, Eugenio, Franzese, Michele, Chianese, Salvatore, Alfani, Arturo, Gerardi, Donato, Colaiori, Iginio, Annunziata, Monica, Nappi, Pierluigi, Scalise, Martina, Di Serafino, Luigi, Puzone, Brunella, Avvedimento, Marisa, Leone, Attilio, Ilardi, Federica, Piccolo, Raffaele, Franzone, Anna, Cirillo, Plinio, Morisco, Carmine, Trimarco, Bruno, and Esposito, Giovanni

Subjects
Male, Acute coronary syndrome, medicine.medical_specialty, medicine.medical_treatment, Angiotensin-Converting Enzyme Inhibitors, Medication Adherence, Angiotensin Receptor Antagonists, Risk Factors, Internal medicine, Secondary Prevention, Humans, Medicine, Registries, Acute Coronary Syndrome, Medical prescription, business.industry, Coronary Care Units, Percutaneous coronary intervention, Cardiovascular Agents, General Medicine, Middle Aged, medicine.disease, University hospital, Patient Discharge, Italy, Logistic analysis, Coronary care unit, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cardiology and Cardiovascular Medicine, business, Index hospitalization, Platelet Aggregation Inhibitors, Cohort study
Abstract

AIMS Adherence to medical therapy following acute coronary syndrome (ACS) affects a patient's prognosis. In this cohort study, we sought to assess the factors that could affect a patient's adherence to therapy after ACS. METHODS We prospectively collected information from patients (N = 964) hospitalized at the coronary care unit of the Federico II University Hospital, from 1 January 2015 to 30 June 2017, for ACS. Adherence to three classes of drugs including statins, antiplatelets [dual or single antiplatelet agent (SAPT)] and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACE-I/ARB) and their composites were assessed at 1 month, 1 and 2 years after discharge. RESULTS At 30 days adherence to prescribed therapy was 94.4% for dual antiplatelet therapy (DAPT), 78.2% for statins, 92.7% for ACE-I/ARB and 70.7% for multitherapy. At 1 year, it was 91.1% for DAPT, 81.2% for ACE-I/ARB, 84.9% for statins and 71.4% for multitherapy. At 2 years, it was 97.1% for SAPT, 78.1% for ACE-I/ARB, 91.8% for statins, 72.8% for multitherapy. Multivariable logistic analysis demonstrated that at each time point, a telephone follow-up assessment predicts nonadherence to multitherapy and that a percutaneous coronary intervention at the index hospitalization is an independent predictor of adherence to composite therapy at 1 month and 1 year. CONCLUSION Up to 2 years after ACS, three out of four patients are adherent to multitherapy prescription; percutaneous coronary intervention during the index hospitalization improves a patient's adherence, whereas telephone follow-up is associated with reduced adherence to multitherapy.Campania Salute Network Registry (Clinical Trials.gov Identifier: NCT02211365).

Published
2021

25. Physiologic Range of Myocardial Mechano-Energetic Efficiency among Healthy Subjects: Impact of Gender and Age

Author

Francesco Ferrara, Valentina Capone, Filippo Cademartiri, Olga Vriz, Rosangela Cocchia, Brigida Ranieri, Monica Franzese, Rossana Castaldo, Antonello D’Andrea, Rodolfo Citro, Salvatore Chianese, Roberto Annunziata, Flavio Marullo, Mario Siniscalchi, Marianna Conte, Chiara Sepe, Renato Maramaldi, Salvatore Rega, Giuseppe Russo, Massimo Majolo, Eliana Raiola, Andrea Salzano, Ciro Mauro, Bruno Trimarco, Raffaele Izzo, Eduardo Bossone, Ferrara, Francesco, Capone, Valentina, Cademartiri, Filippo, Vriz, Olga, Cocchia, Rosangela, Ranieri, Brigida, Franzese, Monica, Castaldo, Rossana, D'Andrea, Antonello, Citro, Rodolfo, Chianese, Salvatore, Annunziata, Roberto, Marullo, Flavio, Siniscalchi, Mario, Conte, Marianna, Sepe, Chiara, Maramaldi, Renato, Rega, Salvatore, Russo, Giuseppe, Majolo, Massimo, Raiola, Eliana, Salzano, Andrea, Mauro, Ciro, Trimarco, Bruno, Izzo, Raffaele, and Bossone, Eduardo

Subjects
myocardial mechanical efficiency, stomatognathic diseases, stomatognathic system, indexed myocardial mechanical efficiency, echocardiography, Medicine (miscellaneous)
Abstract

Background: Myocardial mechano-energetic efficiency (MEE) is the capability of the left ventricle (LV) to convert the chemical energy obtained from the cardiac oxidative metabolism into mechanical work. The aim of present study was to establish normal non-invasive MEE and MEEi reference values. Methods: In total, 1168 healthy subjects underwent physical examinations, clinical assessment, and standardized transthoracic echocardiographic (TTE) examination. MEE was obtained by TTE as the ratio between stroke volume (SV) and heart rate (HR): MEE = SV/HR [HR expressed in seconds (HR/60)]. Because MEE is highly related to left ventricular mass (LVM), MEE was then divided by LVM with the purpose of obtaining an estimate of energetic expenditure per unit of myocardial mass (i.e., indexed MEE, MEEi, mL/s/g). Results: The mean values of MEE and MEEi in the overall population were 61.09 ± 18.19 mL/s; 0.45 ± 0.14, respectively. In a multivariable analysis, gender, body surface area (BSA), diastolic blood pressure, left atrial volume indexed to BSA, E/e’ and tricuspid annular plane systolic excursion (TAPSE) were the independent variables associated with MEE, while age, gender, BSA and TAPSE were the independent variables associated with MEEi. Conclusions: The knowledge of age- and gender-based MEE and MEEi normal values may improve the global assessment of LV cardiac mechanics and serve as a reference to identify phenotypes at high risk of cardiovascular events.

Published
2022

26. Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways

Author

Ciro Mauro, Valentina Capone, Rosangela Cocchia, Filippo Cademartiri, Ferdinando Riccardi, Michele Arcopinto, Maie Alshahid, Kashif Anwar, Mariano Carafa, Andreina Carbone, Rossana Castaldo, Salvatore Chianese, Giulia Crisci, Roberta D’Assante, Mariarosaria De Luca, Monica Franzese, Domenico Galzerano, Vincenzo Maffei, Alberto Maria Marra, Alfredo Mazza, Brigida Ranieri, Anna D’Agostino, Salvatore Rega, Luigia Romano, Sarah Scagliarini, Chiara Sepe, Olga Vriz, Raffaele Izzo, Antonio Cittadini, Eduardo Bossone, Andrea Salzano, Mauro, Ciro, Capone, Valentina, Cocchia, Rosangela, Cademartiri, Filippo, Riccardi, Ferdinando, Arcopinto, Michele, Alshahid, Maie, Anwar, Kashif, Carafa, Mariano, Carbone, Andreina, Castaldo, Rossana, Chianese, Salvatore, Crisci, Giulia, D'Assante, Roberta, De Luca, Mariarosaria, Franzese, Monica, Galzerano, Domenico, Maffei, Vincenzo, Marra, Alberto Maria, Mazza, Alfredo, Ranieri, Brigida, D'Agostino, Anna, Rega, Salvatore, Romano, Luigia, Scagliarini, Sarah, Sepe, Chiara, Vriz, Olga, Izzo, Raffaele, Cittadini, Antonio, Bossone, Eduardo, and Salzano, Andrea

Subjects
cancer therapy-related cardiovascular toxicity, cardio-oncology, General Medicine, chemotherapy
Abstract

Early detection and treatment of cancer have led to a noticeable reduction in both mortality and morbidity. However, chemotherapy and radiotherapy could exert cardiovascular (CV) side effects, impacting survival and quality of life, independent of the oncologic prognosis. In this regard, a high clinical index of suspicion is required by the multidisciplinary care team in order to trigger specific laboratory tests (namely natriuretic peptides and high-sensitivity cardiac troponin) and appropriate imaging techniques (transthoracic echocardiography along with cardiac magnetic resonance, cardiac computed tomography, and nuclear testing (if clinically indicated)), leading to timely diagnosis. In the near future, we do expect a more tailored approach to patient care within the respective community along with the widespread implementation of digital health tools.

Published
2023

27. Prognostic Implications of Declining Hemoglobin Content in Patients Hospitalized With Acute Coronary Syndromes

Author

Felice Gragnano, Marco Valgimigli, Michele Franzese, Fabrizio Esposito, Giuseppe Gargiulo, Marisa Avvedimento, Vincenzo Fioretti, Sergio Leonardi, Vanessa Spedicato, Giuseppe Andò, Fabio Magliulo, Paolo Calabrò, Attilio Leone, Martina Scalise, Stephan Windecker, Alessandra Schiavo, Paolo Mazzone, Greta Carrara, Pascal Vranckx, Salvatore Chianese, Giovanni Esposito, Luigi Fimiani, Emanuele Monda, Enrico Frigoli, Dario Di Maio, Leonardi, S., Gragnano, F., Carrara, G., Gargiulo, G., Frigoli, E., Vranckx, P., Di Maio, D., Spedicato, V., Monda, E., Fimiani, L., Fioretti, V., Esposito, F., Avvedimento, M., Magliulo, F., Leone, A., Chianese, S., Franzese, M., Scalise, M., Schiavo, A., Mazzone, P., Esposito, G., Ando, G., Calabro, P., Windecker, S., Valgimigli, M., Leonardi, Sergio, Gragnano, Felice, Carrara, Greta, Gargiulo, Giuseppe, Frigoli, Enrico, Vranckx, Pascal, Di Maio, Dario, Spedicato, Vanessa, Monda, Emanuele, Fimiani, Luigi, Fioretti, Vincenzo, Esposito, Fabrizio, Avvedimento, Marisa, Magliulo, Fabio, Leone, Attilio, Chianese, Salvatore, Franzese, Michele, Scalise, Martina, Schiavo, Alessandra, Mazzone, Paolo, Esposito, Giovanni, Andò, Giuseppe, Calabrò, Paolo, Windecker, Stephan, and Valgimigli, Marco

Subjects
Male, medicine.medical_specialty, Acute coronary syndrome, Randomization, medicine.medical_treatment, Hemorrhage, 030204 cardiovascular system & hematology, acute coronary syndrome, 03 medical and health sciences, Hemoglobins, 0302 clinical medicine, Internal medicine, medicine, Humans, In patient, 030212 general & internal medicine, 610 Medicine & health, Aged, Aged, 80 and over, Inpatients, business.industry, Incidence (epidemiology), Hazard ratio, percutaneous coronary intervention, Percutaneous coronary intervention, Middle Aged, hemoglobin, medicine.disease, Prognosis, bleeding, Confidence interval, Europe, Cardiology, Female, Hemoglobin, Cardiology and Cardiovascular Medicine, business
Abstract

BACKGROUND Contemporary definitions of bleeding endpoints are restricted mostly to clinically overt events. Whether hemoglobin drop per se, with or without overt bleeding, adversely affects the prognosis of patients with acute coronary syndrome (ACS) remains unclear. OBJECTIVES The aim of this study was to examine in the MATRIX (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial the incidence, predictors, and prognostic implications of in-hospital hemoglobin drop in patients with ACS managed invasively stratified by the presence of in-hospital bleeding. METHODS Patients were categorized by the presence and amount of in-hospital hemoglobin drop on the basis of baseline and nadir hemoglobin values and further stratified by the occurrence of adjudicated in-hospital bleeding. Hemoglobin drop was defined as minimal (

Published
2021

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