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Your search keyword '"Chen, Sunrui"' showing total 25 results
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25 results on '"Chen, Sunrui"'

4. Standardization of organoid culture in cancer research

Author

Zhou, Changchun, primary, Wu, Yuanbo, additional, Wang, Zeyu, additional, Liu, Yanli, additional, Yu, Jiaqi, additional, Wang, Weiping, additional, Chen, Sunrui, additional, Wu, Weihua, additional, Wang, Jidong, additional, Qian, Guowei, additional, and He, Aina, additional

Published
2023
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5. Inhibition of Autophagy Promotes the Elimination of Liver Cancer Stem Cells by CD133 Aptamer-Targeted Delivery of Doxorubicin

Author

Yin, Wang, primary, Pham, Cuong V., additional, Wang, Tao, additional, Al Shamaileh, Hadi, additional, Chowdhury, Rocky, additional, Patel, Shweta, additional, Li, Yong, additional, Kong, Lingxue, additional, Hou, Yingchu, additional, Zhu, Yimin, additional, Chen, Sunrui, additional, Xu, Huo, additional, Jia, Lee, additional, Duan, Wei, additional, and Xiang, Dongxi, additional

Published
2022
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8. High-dose vitamin D metabolite delivery inhibits breast cancer metastasis

Author

Liu, Jiaye, Shen, Junyi, Mu, Chunyang, Liu, Yang, He, Dongsheng, Luo, Han, Wu, Wenshuang, Zheng, Xun, Liu, Yi, Chen, Sunrui, Pan, Qiuwei, Hu, Yiguo, Ni, Yinyun, Wang, Yang, Liu, Yong, Li, Zhihui, Liu, Jiaye, Shen, Junyi, Mu, Chunyang, Liu, Yang, He, Dongsheng, Luo, Han, Wu, Wenshuang, Zheng, Xun, Liu, Yi, Chen, Sunrui, Pan, Qiuwei, Hu, Yiguo, Ni, Yinyun, Wang, Yang, Liu, Yong, and Li, Zhihui

Abstract

Besides its well-known benefits on human health, calcitriol, the hormonally active form of vitamin D3, has been being evaluated in clinical trials as an anticancer agent. However, currently available results are contradictory and not fundamentally deciphered. To the best of our knowledge, hypercalcemia caused by high-dose calcitriol administration and its low bioavailability limit its anticancer investigations and translations. Here, we show that the one-step self-assembly of calcitriol and amphiphilic cholesterol-based conjugates leads to the formation of a stable minimalist micellar nanosystem. When administered to mice, this nanosystem demonstrates high calcitriol doses in breast tumor cells, significant tumor growth inhibition and antimetastasis capability, as well as good biocompatibility. We further reveal that the underlying molecular antimetastatic mechanisms involve downregulation of proteins facilitating metastasis and upregulation of paxillin, the key protein of focal adhesion, in primary tumors.

Published
2022

9. High‐dose vitamin D metabolite delivery inhibits breast cancer metastasis

Author

Liu, Jiaye, primary, Shen, Junyi, additional, Mu, Chunyang, additional, Liu, Yang, additional, He, Dongsheng, additional, Luo, Han, additional, Wu, Wenshuang, additional, Zheng, Xun, additional, Liu, Yi, additional, Chen, Sunrui, additional, Pan, Qiuwei, additional, Hu, Yiguo, additional, Ni, Yinyun, additional, Wang, Yang, additional, Liu, Yong, additional, and Li, Zhihui, additional

Published
2021
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24. PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target.

Author

Yin, Yuebang, Dang, Wen, Zhou, Xinying, Xu, Lei, Wang, Wenshi, Cao, Wanlu, Chen, Sunrui, Su, Junhong, Cai, Xuepeng, Xiao, Shaobo, Peppelenbosch, Maikel P., and Pan, Qiuwei

Subjects
ROTAVIRUS diseases, ANTIVIRAL agents, IMMUNOCOMPROMISED patients, MTOR protein, AUTOPHAGY, DRUG development
Abstract

Rotavirus infection is a major cause of severe dehydrating diarrhea in infants younger than 5 y old and in particular cases of immunocompromised patients irrespective to the age of the patients. Although vaccines have been developed, antiviral therapy is an important complement that cannot be substituted. Because of the lack of specific approved treatment, it is urgent to facilitate the cascade of further understanding of the infection biology, identification of druggable targets and the final development of effective antiviral therapies. PI3K-Akt-mTOR signaling pathway plays a vital role in regulating the infection course of many viruses. In this study, we have dissected the effects of PI3K-Akt-mTOR signaling pathway on rotavirus infection using both conventional cell culture models and a 3D model of human primary intestinal organoids. We found that PI3K-Akt-mTOR signaling is essential in sustaining rotavirus infection. Thus, blocking the key elements of this pathway, including PI3K, mTOR and 4E-BP1, has resulted in potent anti-rotavirus activity. Importantly, a clinically used mTOR inhibitor, rapamycin, potently inhibited both experimental and patient-derived rotavirus strains. This effect involves 4E-BP1 mediated induction of autophagy, which in turn exerts anti-rotavirus effects. These results revealed new insights on rotavirus-host interactions and provided new avenues for antiviral drug development. [ABSTRACT FROM AUTHOR]

Published
2018
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25. HBV infection effects prognosis and activates the immune response in intrahepatic cholangiocarcinoma.

Author

Li Z, Gao Q, Wu Y, Ma X, Wu F, Luan S, Chen S, Shao S, Shen Y, Zhang D, Feng F, Yuan L, and Wei S

Subjects
Animals, Humans, Hepatitis B virus, Hepatitis B Surface Antigens, Retrospective Studies, Neoplasm Recurrence, Local, Prognosis, Disease Models, Animal, Bile Ducts, Intrahepatic, Immunity, Cholangiocarcinoma genetics, Cholangiocarcinoma surgery, Bile Duct Neoplasms surgery
Abstract

Background: The impact of HBV infection on the prognosis of patients with intrahepatic cholangiocarcinoma (ICC) remains uncertain, and the underlying mechanism has not been elucidated. This study aims to explore the potential mechanism via clinical perspectives and immune features., Methods: We retrospectively reviewed 1308 patients with ICC treated surgically from January 2007 to January 2015. Then, we compared immune-related markers using immunohistochemistry staining to obtain the gene expression profile GSE107943 and related literature for preliminary bioinformatics analysis. Subsequently, we conducted a drug sensitivity assay to validate the role of TNFSF9 in the ICC organoid-autologous immune cell coculture system and in the patient-derived organoids-based xenograft platform., Results: The analysis revealed that tumors in patients without HBV infection exhibited greater size and a higher likelihood of lymphatic metastasis, tumor invasion, and relapse. After resection, HBV-infected patients had longer survival time than uninfected patients (p<0.01). Interestingly, the expression of immune-related markers in HBV-positive patients with ICC was higher than that in uninfected patients (p<0.01). The percentage of CD8+ T cells in HBV-positive tissue was higher than that without HBV infection (p<0.05). We screened 21 differentially expressed genes and investigated the function of TNFSF9 through bioinformatics analyses. The expression of TNFSF9 in ICC organoids with HBV infection was lower than that in organoids without HBV infection. The growth of HBV-negative ICC organoids was significantly inhibited by inhibiting the expression of TNFSF9 with a neutralizing antibody. Additionally, the growth rate was faster in HbsAg (-) ICC patient-derived organoids-based xenograft model than in HbsAg (+) group., Conclusions: The activation of the immune response induced by HBV infection makes the prognosis of HBV-positive patients with ICC differ from that of uninfected patients., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.)

Published
2024
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