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ABSTRACT A meta-analysis was employed to assess the effects of phytogenic feed additives and antibiotics on the performance and intestinal morphometry of unchallenged weanling pigs. The database included 41 articles published between 2004 and 2017, comprising 5,197 unchallenged nursery piglets. Piglets had 7.7 to 13.8 kg body weight and were assessed at 27.3 to 47.8 days of age, distributed into 156 experimental groups. All treatments were categorized into negative control, phytogenic additive (PA), and antibiotics (ATB) groups. The meta-analysis followed two sequential analyses: graphical and variance-covariance. Age and body weight were the factors that highly influenced the model. Piglets that received antibiotics had a higher (12.2%) daily weight gain than piglets in the control group. Phytogenic additives in diets enhanced intestinal morphometry in unchallenged piglets. Antibiotics increased (by 12.7%) the crypt depth of jejunum in comparison to the control treatment. Animals on PA had an 11.1% increment in villus height:crypt depth ratio than those on antibiotics. Phytogenic additives and antibiotics boost nursery piglet performance. Antibiotics advances the performance of unchallenged nursery piglets, but increases crypt depth in the jejunum. Performance of nursery piglets is better with combined phytogenic additives than with the isolated use of plant extracts.