Search

Your search keyword '"Centurioni, C."' showing total 7 results
Start Over Author "Centurioni, C." Publication Year Range Last 50 years
7 results on '"Centurioni, C."'

1. Der 'schwierige Patient'

Author

Centurioni, C., Harrer, M. E., Frischenschlager, O., editor, Hexel, M., editor, Kantner-Rumplmair, W., editor, Ringler, M., editor, Söllner, W., editor, and Wisiak, U. V., editor

Published
1995
Full Text
View/download PDF

4. Influence of reduced muscle mass and quality on ventilator weaning and complications during intensive care unit stay in COVID-19 patients

Author

Valentina Da Prat, Francesco De Cobelli, Giuseppe A. Ramirez, Giovanni Borghi, Agnese Gobbi, Giulia Cristel, Maria Grazia Calabrò, Ettore Di Gaeta, Giovanni Landoni, Clarissa Centurioni, Sarah Damanti, Alberto Zangrillo, Moreno Tresoldi, Andrea Del Prete, Enrica Bozzolo, Maria Rosa Calvi, Damanti, S., Cristel, G., Ramirez, G. A., Bozzolo, E. P., Da Prat, V., Gobbi, A., Centurioni, C., Di Gaeta, E., Del Prete, A., Calabro, M. G., Calvi, M. R., Borghi, G., Zangrillo, A., De Cobelli, F., Landoni, G., and Tresoldi, M.

Subjects
Adult, Critical Care and Intensive Care Medicine, law.invention, Ventilator weaning, law, medicine, Humans, Weaning, Intensive care unit, Respiratory system, Pandemics, Muscle quality, Nutrition and Dietetics, SARS-CoV-2, business.industry, Muscles, Medical record, COVID-19, Muscle mass, Length of Stay, medicine.disease, Respiration, Artificial, Intensive Care Units, Observational Studies as Topic, Pneumonia, Anesthesia, Sarcopenia, Breathing, Observational study, business
Abstract

Summary Background & aims Sarcopenia, a loss of muscle mass, quality and function, which is particularly evident in respiratory muscles, has been associated with many clinical adverse outcomes. In this study, we aimed at evaluating the role of reduced muscle mass and quality in predicting ventilation weaning, complications, length of intensive care unit (ICU) and of hospital stay and mortality in patients admitted to ICU for SARS-CoV-2-related pneumonia. Methods This was an observational study based on a review of medical records of all adult patients admitted to the ICU of a tertiary hospital in Milan and intubated for SARS-CoV-2-related pneumonia during the first wave of the COVID-19 pandemic. Muscle mass and quality measurement were retrieved from routine thoracic CT scans, when sections passing through the first, second or third lumbar vertebra were available. Results A total of 81 patients were enrolled. Muscle mass was associated with successful extubation (OR 1.02, 95% C.I. 1.00–1.03, p = 0.017), shorter ICU stay (OR 0.97, 95% C.I. 0.95–0.99, p = 0.03) and decreased hospital mortality (HR 0.98, 95% C.I. 0.96–0.99, p = 0.02). Muscle density was associated with successful extubation (OR 1.07, 95% C.I. 1.01–1.14; p = 0.02) and had an inverse association with the number of complications in ICU (Β −0.07, 95% C.I. −0.13 - −0.002, p = 0.03), length of hospitalization (Β −1.36, 95% C.I. −2.21 - −0.51, p = 0.002) and in-hospital mortality (HR 0.88, 95% C.I. 0.78–0.99, p = 0.046). Conclusions Leveraging routine CT imaging to measure muscle mass and quality might constitute a simple, inexpensive and powerful tool to predict survival and disease course in patients with COVID-19. Preserving muscle mass during hospitalisation might have an adjuvant role in facilitating remission from COVID-19.

Published
2022
Full Text
View/download PDF

5. Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency

Author

Sarah Damanti, Giuseppe Alvise Ramirez, Enrica Paola Bozzolo, Valentina Da Prat, Giuseppe Di Lucca, Gaetano Di Terlizzi, Alessandro Marinosci, Raffaella Scotti, Silvia Strada, Paolo Scarpellini, Barbara Castiglioni, Chiara Oltolini, Marco Ripa, Chiara Tassan Din, Clarissa Elisabeth Centurioni, Flavia Di Scala, Agnese Gobbi, Ada Carla Alba, Giuseppina Maria Casiraghi, Anna Morgillo, Moreno Tresoldi, Damanti, S., Ramirez, G. A., Bozzolo, E. P., Da Prat, V., Di Lucca, G., Di Terlizzi, G., Marinosci, A., Scotti, R., Strada, S., Scarpellini, P., Castiglioni, B., Oltolini, C., Ripa, M., Din, C. T., Centurioni, C. E., Di Scala, F., Gobbi, A., Alba, A. C., Casiraghi, G. M., Morgillo, A., and Tresoldi, M.

Subjects
Male, Aging, Frailty, Continuous Positive Airway Pressure, Frail Elderly, COVID-19, Comorbidity, Non-invasive ventilation, Humans, Female, Geriatrics and Gerontology, Mortality, Respiratory Insufficiency, Geriatric Assessment, Aged
Abstract

Objective: Exploring the association between frailty and mortality in a cohort of patients with COVID-19 respiratory insufficiency treated with continuous positive airway pressure. Methods: Frailty was measured using a Frailty Index (FI) created by using the baseline assessment data on comorbidities and body mass index and baseline blood test results (including pH, lactate dehydrogenase, renal and liver function, inflammatory indexes and anemia). FI > 0.25 identified frail individuals. Results: Among the 159 included individuals (81% men, median age of 68) frailty was detected in 69% of the patients (median FI score 0.3 ± 0.08). Frailty was associated to an increased mortality (adjusted HR 1.99, 95% CI 1.02–3.88, p = 0.04). Conclusions: Frailty is highly prevalent among patients with COVID-19, predicts poorer outcomes independently of age. A personalization of care balancing the risk and benefit of treatments (especially the invasive ones) in such complex patients is pivotal.

Published
2022

6. Outcomes of noninvasive ventilation as the ceiling of treatment in patients with COVID-19.

Author

Ramirez GA, Bozzolo EP, Gobbi A, Castelli E, Centurioni C, DI Meo M, Della Torre E, DI Scala F, Morgillo A, Marinosci A, Miglio M, Scarpellini P, Tassan Din C, Castiglioni B, Oltolini C, Ripa M, DI Terlizzi G, DA Prat V, Damanti S, Scotti R, DI Lucca G, Baiardo Redaelli M, Plumari VP, Moizo E, Carcó F, Silvani P, DE Cobelli F, Landoni G, and Tresoldi M

Subjects
Humans, Aged, Respiration, Artificial, Continuous Positive Airway Pressure, Noninvasive Ventilation adverse effects, COVID-19 therapy, Respiratory Insufficiency therapy
Abstract

Background: Non-invasive mechanical ventilation (NIV) is effective for symptom relief and respiratory support in patients with respiratory insufficiency, severe comorbidities and no indication to intubation. Experience with NIV as the ceiling of treatment in severely compromised novel coronavirus disease (COVID-19) patients is lacking., Methods: We evaluated 159 patients with COVID-19-related acute respiratory syndrome (ARDS), 38 of whom with NIV as the ceiling of treatment, admitted to an ordinary ward and treated with continuous positive airway pressure (CPAP) and respiratory physiotherapy. Treatment failure and death were correlated with clinical and laboratory parameters in the whole cohort and in patients with NIV as the ceiling of treatment., Results: Patients who had NIV as the ceiling of treatment were elderly, with a low BMI and a high burden of comorbidities, showed clinical and laboratory signs of multiorgan insufficiency on admission and of rapidly deteriorating vital signs during the first week of treatment. NIV failure occurred overall in 77 (48%) patients, and 27/38 patients with NIV as the ceiling of treatment died. Congestive heart failure, chronic benign hematological diseases and inability/refusal to receive respiratory physiotherapy were independently associated to NIV failure and mortality. Need for increased positive end-expiratory pressures and low platelets were associated with NIV failure. Death was associated to cerebrovascular disease, need for CPAP cycles longer than 12 h and, in the subgroup of patients with NIV as the ceiling of treatment, was heralded by vital sign deterioration within 48 h., Conclusions: NIV and physiotherapy are a viable treatment option for patients with severe COVID-19 and severe comorbidities.

Published
2022
Full Text
View/download PDF

7. Continuous positive airway pressure and pronation outside the Intensive Care Unit in COVID-19 acute respiratory distress syndrome.

Author

Ramirez GA, Bozzolo EP, Castelli E, Marinosci A, Angelillo P, Damanti S, Scotti R, Gobbi A, Centurioni C, DI Scala F, Morgillo A, Castagna A, Conte C, Assanelli A, DE Cobelli F, Calcaterra B, Cabrini L, Carcò F, Turi S, Silvani P, Dagna L, Zangrillo A, Landoni G, and Tresoldi M

Subjects
Adult, Cohort Studies, Continuous Positive Airway Pressure, Humans, Intensive Care Units, Pronation, COVID-19 complications, COVID-19 therapy, Respiratory Distress Syndrome therapy
Abstract

Background: The efficacy and safety of continuous positive airway pressure and respiratory physiotherapy outside the Intensive Care Unit during a pandemic., Methods: In this cohort study performed in February-May 2020 in a large teaching hospital in Milan, COVID-19 patients with adult respiratory distress syndrome receiving continuous positive airway pressure (positive end-expiratory pressure =10 cm H2O, FiO2=0.6, daily treatment duration: 4×3h-cycles) and respiratory physiotherapy including pronation outside the Intensive Care Unit were followed-up., Results: Of 90 acute respiratory distress syndrome (ARDS) patients treated with continuous positive airway pressure (45/90, 50% pronated at least once) outside the Intensive Care Unit and with a median (interquartile) follow-up of 37 (11-46) days, 45 (50%) were discharged at home, 28 (31%) were still hospitalized, and 17 (19%) died. Continuous positive airway pressure failure was recorded for 35 (39%) patients. Patient mobilization was associated with reduced failure rates (P=0.033). No safety issues were observed., Conclusions: Continuous positive airway pressure with patient mobilization (including pronation) was effective and safe in patients with ARDS due to COVID-19 managed outside the Intensive Care Unit setting during the pandemic.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results