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3. Examining the effect of red blood cell collisions using a fully eulerian simulation approach

Author

Valtchanov, H., Cecere, R., Mongrain, R., Valtchanov, H., Cecere, R., and Mongrain, R.

Abstract

Computational fluid dynamics simulations are employed using the volume of fluid multiphase approach to simulate the fluid structure interaction dynamics of red blood cells in a Couette shear flow. A fully Eulerian structural approach is employed using a finite volume solver to simulate the structural dynamics in order to eliminate the need to Re-mesh the fluid portion of the simulation. Transport equations are defined for the components of the Left Cauchy deformation tensor, from which a solid stress is computed and directly incorporated into the momentum equations. Several improvements are made to the standard fully Eulerian approach for fluid structure interaction. A hyper-elastic strain energy function based on the Yeoh Model fit using optical tweezers that enforces area incompressibility is developed to model the higher-order strain stiffening behavior of the red blood cell. Furthermore, a boundary shape function is developed to compute the distance to the membrane and alleviate issues of numerical diffusion associated with the diffusion of the membrane. The method is implemented in ANSYS Fluent, validated, and compared against the simple analytical solutions for a droplet in a Couette shear flow, as well as compared against images of deformed red blood cells in a shear flow. Multiple Simulations are executed to examine the effect of red blood cell packing on the strain induced on nearby cells during collision vents. It is found that the traction applied on the red blood cell membrane by the fluid is locally increased by up to a factor of three, and depends on red blood cell packing. There is a noticeable local increase in strain observed due to red blood cell collisions. Please do not exceed one page. Please do not add references or figures to this text-only abstract., Résumé de la communication présentée lors du congrès international tenu conjointement par Canadian Society for Mechanical Engineering (CSME) et Computational Fluid Dynamics Society of Canada (CFD Canada), à l’Université de Sherbrooke (Québec), du 28 au 31 mai 2023.

Published
2023

4. Anxiety Sensitivity Domains are Differently Affected by Social and Non-social Autistic Traits

Author

Baiano C., Raimo G., Zappullo I., Cecere R., Rauso B., Positano M., Conson M., Aversana L. D., Di Rosa A., Esposito G., Milo R., Polito F., Raimondo C., Turco A., Baiano, C., Raimo, G., Zappullo, I., Cecere, R., Rauso, B., Positano, M., Conson, M., Aversana, L. D., Di Rosa, A., Esposito, G., Milo, R., Polito, F., Raimondo, C., and Turco, A.

Subjects
Autism-spectrum quotient, Autism Spectrum Disorder, Anxiety, Surveys and Questionnaires, Developmental and Educational Psychology, medicine, Humans, Autistic Disorder, Autistic trait, Depression (differential diagnoses), Anxiety sensitivity, Cognitive concern, Depression, Cognition, Social concerns, Sex difference, medicine.disease, Anxiety Disorders, Autistic traits, Autism, medicine.symptom, Psychology, Clinical psychology, Psychopathology
Abstract

Anxiety sensitivity (AS) is implicated in the development and maintenance of several psychopathological conditions. Non-clinical individuals with high autistic traits may develop anxiety disorders and depressive symptoms. Here, we investigated the relationships of autistic traits with AS dimensions and depression, considering sex. We referred to the two-factor model of the autism spectrum quotient to distinguish social and non-social autistic traits and assessed 345 university students on AS and depression scales. Results showed that only social autistic traits predicted general AS and anxiety-related concerns regarding social and cognitive domains. The present results emphasize the need of assessing multiple domains of anxiety in individuals on the autistic spectrum, differentiating social and non-social traits.

Published
2021
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6. Figure Disembedding: The Gottschaldt's Hidden Figure Test in Children with Typical Development and Autism

Author

Conson M., Siciliano M., Trojano L., Zoccolotti P., Zappullo I., Baiano C., Caputo G., Russo A., Cecere R., Di Rosa A., Esposito G., Milo R., Polito F., Rauso B., Vela M., Santangelo G., Conson, M., Siciliano, M., Trojano, L., Zoccolotti, P., Zappullo, I., Baiano, C., Caputo, G., Russo, A., Cecere, R., Di Rosa, A., Esposito, G., Milo, R., Polito, F., Rauso, B., Vela, M., and Santangelo, G.

Subjects
Perceptual style, Autism Spectrum Disorder, Cognition, medicine.disease, Perception of detail, Large sample, Test (assessment), Developmental psychology, Age groups, Developmental and Educational Psychology, medicine, Normative, Autism, Humans, Hidden figure, Autistic Disorder, Psychology, Child, Time score, Figure disembedding, Socioeconomic differences
Abstract

In two studies, we used the Gottschaldt’s Hidden Figure Test (GHFT) for assessing figure disembedding ability in children aged 7–11. Study 1 demonstrated in a large sample of typically developing children that GHFT accuracy and time scores differed across age groups, without sex and socioeconomic differences. Thus, we provided normative data only taking into account children’s age. In Study 2, GHFT normative values were used to assess children with autism, who were also compared with a closely age-matched group of typical controls. Children with autism achieved time scores at or above the 50th centile and significantly differed from the controls for time score. The GHFT seems a valuable tool for defining the cognitive profile of children with autism.

Published
2021

10. Safety and efficacy of ombitasvir/paritaprevir/ritonavir/dasabuvir plus ribavirin in patients over 65 years with HCV genotype 1 cirrhosis

Author

Ascione, A, De Luca, M, Melazzini, M, Montilla, S, Trotta, M, Petta, S, Puoti, M, Sangiovanni, V, Messina, V, Bruno, S, Izzi, A, Villa, E, Aghemo, A, Zignego, A, Orlandini, A, Fontanella, L, Gasbarrini, A, Marzioni, M, Giannini, E, Craxi, A, Abbati, G, Alberti, A, Andreone, P, Andreoni, M, Angeli, P, Angelico, M, Angarano, G, Angrisani, D, Antinori, A, Antonini, C, Avancini, I, Barone, M, Bruno, R, Benedetti, A, Bernabucci, V, Blanc, P, Boarini, C, Boffa, N, Boglione, L, Borghi, V, Borgia, G, Brancaccio, G, Brunetto, M, Cacciola, I, Calabrese, P, Calvaruso, V, Campagnolo, D, Canovari, B, Caporaso, N, Capra, F, Carolo, G, Cassola, G, Castelli, F, Cauda, R, Silberstein, F, Cecere, R, Chessa, L, Chiodera, A, Chirianni, A, Ciancio, A, Cima, S, Coco, B, Colombo, M, Coppola, N, Corti, G, Cosco, L, Corradori, S, Cozzolongo, R, Cristaudo, A, Danieli, E, Monforte, A, Monache, M, Del Poggio, P, de Luca, A, Dentone, C, Di Biagio, A, Di Leo, A, Di Perri, G, Di Stefano, M, D'Offizi, G, Donato, F, Durante, E, Erne, E, Fagiuoli, S, Falasca, K, Federico, A, Felder, M, Ferrari, C, Gaeta, G, Ganga, R, Gatti, P, Giacomet, V, Giacometti, A, Gianstefani, A, Giordani, M, Giorgini, A, Grieco, A, Guerra, M, Gulminetti, R, Ieluzzi, D, Imparato, M, Iodice, V, La Monica, S, Lazzarin, A, Lenzi, M, Levrero, M, Lichtner, M, Lionetti, R, Guercio, C, Madonna, S, Magnani, S, Maida, I, Marignani, M, Marrone, A, Marsetti, F, Martini, S, Masarone, M, Maserati, R, Mastroianni, C, Memoli, M, Menzaghi, B, Merli, M, Miele, L, Milella, M, Mondelli, M, Montalbano, M, Monti, M, Morelli, O, Morisco, F, Nardone, G, Novara, S, Onnelli, G, Onofrio, M, Paganin, S, Pani, L, Parisi, M, Parruti, G, Pasquazzi, C, Pasulo, L, Perno, C, Persico, M, Piai, G, Picciotto, A, Pigozzi, G, Piovesan, S, Piras, M, Pirisi, M, Piscaglia, A, Ponti, L, Potenza, D, Pravadelli, C, Quartini, M, Quirino, T, Raimondo, G, Rapaccini, G, Rendina, M, Rizzardini, G, Rizzetto, M, Rizzo, S, Romagnoli, D, Romano, A, Rossi, C, Rumi, M, Russello, M, Russo, F, Russo, M, Sansonno, D, Santantonio, T, Saracco, G, Schimizzi, A, Serviddio, G, Simeone, F, Solinas, A, Soria, A, Tabone, M, Taliani, G, Tarantino, G, Tarquini, P, Tavio, M, Termite, A, Teti, E, Toniutto, P, Torti, C, Tundi, P, Vecchiet, G, Verucchi, G, Gentilucci, U, Vinci, M, Vullo, V, Zolfino, T, Zuin, M, Ascione A., De Luca M., Melazzini M., Montilla S., Trotta M. P., Petta S., Puoti M., Sangiovanni V., Messina V., Bruno S., Izzi A., Villa E., Aghemo A., Zignego A. L., Orlandini A., Fontanella L., Gasbarrini A., Marzioni M., Giannini E. G., Craxi A., Abbati G., Alberti A., Andreone P., Andreoni M., Angeli P., Angelico M., Angarano G., Angrisani D., Antinori A., Antonini C., Avancini I., Barone M., Bruno R., Benedetti A., Bernabucci V., Blanc P., Boarini C., Boffa N., Boglione L., Borghi V., Borgia G., Brancaccio G., Brunetto M., Cacciola I., Calabrese P., Calvaruso V., Campagnolo D., Canovari B., Caporaso N., Capra F., Carolo G., Cassola G., Castelli F., Cauda R., Silberstein F. C., Cecere R., Chessa L., Chiodera A., Chirianni A., Ciancio A., Cima S., Coco B., Colombo M., Coppola N., Corti G., Cosco L., Corradori S., Cozzolongo R., Cristaudo A., Danieli E., Monforte A. D. A., Monache M., Del Poggio P., de Luca A., Dentone C., Di Biagio A., Di Leo A., Di Perri G., Di Stefano M., D'Offizi G., Donato F., Durante E., Erne E., Fagiuoli S., Falasca K., Federico A., Felder M., Ferrari C., Gaeta G. B., Ganga R., Gatti P., Giacomet V., Giacometti A., Gianstefani A., Giordani M., Giorgini A., Grieco A., Guerra M., Gulminetti R., Ieluzzi D., Imparato M., Iodice V., La Monica S., Lazzarin A., Lenzi M., Levrero M., Lichtner M., Lionetti R., Guercio C. L., Madonna S., Magnani S., Maida I., Marignani M., Marrone A., Marsetti F., Martini S., Masarone M., Maserati R., Mastroianni C. M., Memoli M., Menzaghi B., Merli M., Miele L., Milella M., Mondelli M., Montalbano M., Monti M., Morelli O., Morisco F., Nardone G., Novara S., Onnelli G., Onofrio M., Paganin S., Pani L., Parisi M. R., Parruti G., Pasquazzi C., Pasulo L., Perno C. F., Persico M., Piai G., Picciotto A., Pigozzi G. M., Piovesan S., Piras M. C., Pirisi M., Piscaglia A. M., Ponti L., Potenza D., Pravadelli C., Quartini M., Quirino T., Raimondo G., Rapaccini G. L., Rendina M., Rizzardini G., Rizzetto M., Rizzo S., Romagnoli D., Romano A., Rossi C., Rumi M. G., Russello M., Russo F. P., Russo M. L., Sansonno D. E., Santantonio T. A., Saracco G., Schimizzi A. M., Serviddio G., Simeone F., Solinas A., Soria A., Tabone M., Taliani G., Tarantino G., Tarquini P., Tavio M., Termite A., Teti E., Toniutto P., Torti C., Tundi P., Vecchiet G., Verucchi G., Gentilucci U. V., Vinci M., Vullo V., Zolfino T., Zuin M., Ascione, A, De Luca, M, Melazzini, M, Montilla, S, Trotta, M, Petta, S, Puoti, M, Sangiovanni, V, Messina, V, Bruno, S, Izzi, A, Villa, E, Aghemo, A, Zignego, A, Orlandini, A, Fontanella, L, Gasbarrini, A, Marzioni, M, Giannini, E, Craxi, A, Abbati, G, Alberti, A, Andreone, P, Andreoni, M, Angeli, P, Angelico, M, Angarano, G, Angrisani, D, Antinori, A, Antonini, C, Avancini, I, Barone, M, Bruno, R, Benedetti, A, Bernabucci, V, Blanc, P, Boarini, C, Boffa, N, Boglione, L, Borghi, V, Borgia, G, Brancaccio, G, Brunetto, M, Cacciola, I, Calabrese, P, Calvaruso, V, Campagnolo, D, Canovari, B, Caporaso, N, Capra, F, Carolo, G, Cassola, G, Castelli, F, Cauda, R, Silberstein, F, Cecere, R, Chessa, L, Chiodera, A, Chirianni, A, Ciancio, A, Cima, S, Coco, B, Colombo, M, Coppola, N, Corti, G, Cosco, L, Corradori, S, Cozzolongo, R, Cristaudo, A, Danieli, E, Monforte, A, Monache, M, Del Poggio, P, de Luca, A, Dentone, C, Di Biagio, A, Di Leo, A, Di Perri, G, Di Stefano, M, D'Offizi, G, Donato, F, Durante, E, Erne, E, Fagiuoli, S, Falasca, K, Federico, A, Felder, M, Ferrari, C, Gaeta, G, Ganga, R, Gatti, P, Giacomet, V, Giacometti, A, Gianstefani, A, Giordani, M, Giorgini, A, Grieco, A, Guerra, M, Gulminetti, R, Ieluzzi, D, Imparato, M, Iodice, V, La Monica, S, Lazzarin, A, Lenzi, M, Levrero, M, Lichtner, M, Lionetti, R, Guercio, C, Madonna, S, Magnani, S, Maida, I, Marignani, M, Marrone, A, Marsetti, F, Martini, S, Masarone, M, Maserati, R, Mastroianni, C, Memoli, M, Menzaghi, B, Merli, M, Miele, L, Milella, M, Mondelli, M, Montalbano, M, Monti, M, Morelli, O, Morisco, F, Nardone, G, Novara, S, Onnelli, G, Onofrio, M, Paganin, S, Pani, L, Parisi, M, Parruti, G, Pasquazzi, C, Pasulo, L, Perno, C, Persico, M, Piai, G, Picciotto, A, Pigozzi, G, Piovesan, S, Piras, M, Pirisi, M, Piscaglia, A, Ponti, L, Potenza, D, Pravadelli, C, Quartini, M, Quirino, T, Raimondo, G, Rapaccini, G, Rendina, M, Rizzardini, G, Rizzetto, M, Rizzo, S, Romagnoli, D, Romano, A, Rossi, C, Rumi, M, Russello, M, Russo, F, Russo, M, Sansonno, D, Santantonio, T, Saracco, G, Schimizzi, A, Serviddio, G, Simeone, F, Solinas, A, Soria, A, Tabone, M, Taliani, G, Tarantino, G, Tarquini, P, Tavio, M, Termite, A, Teti, E, Toniutto, P, Torti, C, Tundi, P, Vecchiet, G, Verucchi, G, Gentilucci, U, Vinci, M, Vullo, V, Zolfino, T, Zuin, M, Ascione A., De Luca M., Melazzini M., Montilla S., Trotta M. P., Petta S., Puoti M., Sangiovanni V., Messina V., Bruno S., Izzi A., Villa E., Aghemo A., Zignego A. L., Orlandini A., Fontanella L., Gasbarrini A., Marzioni M., Giannini E. G., Craxi A., Abbati G., Alberti A., Andreone P., Andreoni M., Angeli P., Angelico M., Angarano G., Angrisani D., Antinori A., Antonini C., Avancini I., Barone M., Bruno R., Benedetti A., Bernabucci V., Blanc P., Boarini C., Boffa N., Boglione L., Borghi V., Borgia G., Brancaccio G., Brunetto M., Cacciola I., Calabrese P., Calvaruso V., Campagnolo D., Canovari B., Caporaso N., Capra F., Carolo G., Cassola G., Castelli F., Cauda R., Silberstein F. C., Cecere R., Chessa L., Chiodera A., Chirianni A., Ciancio A., Cima S., Coco B., Colombo M., Coppola N., Corti G., Cosco L., Corradori S., Cozzolongo R., Cristaudo A., Danieli E., Monforte A. D. A., Monache M., Del Poggio P., de Luca A., Dentone C., Di Biagio A., Di Leo A., Di Perri G., Di Stefano M., D'Offizi G., Donato F., Durante E., Erne E., Fagiuoli S., Falasca K., Federico A., Felder M., Ferrari C., Gaeta G. B., Ganga R., Gatti P., Giacomet V., Giacometti A., Gianstefani A., Giordani M., Giorgini A., Grieco A., Guerra M., Gulminetti R., Ieluzzi D., Imparato M., Iodice V., La Monica S., Lazzarin A., Lenzi M., Levrero M., Lichtner M., Lionetti R., Guercio C. L., Madonna S., Magnani S., Maida I., Marignani M., Marrone A., Marsetti F., Martini S., Masarone M., Maserati R., Mastroianni C. M., Memoli M., Menzaghi B., Merli M., Miele L., Milella M., Mondelli M., Montalbano M., Monti M., Morelli O., Morisco F., Nardone G., Novara S., Onnelli G., Onofrio M., Paganin S., Pani L., Parisi M. R., Parruti G., Pasquazzi C., Pasulo L., Perno C. F., Persico M., Piai G., Picciotto A., Pigozzi G. M., Piovesan S., Piras M. C., Pirisi M., Piscaglia A. M., Ponti L., Potenza D., Pravadelli C., Quartini M., Quirino T., Raimondo G., Rapaccini G. L., Rendina M., Rizzardini G., Rizzetto M., Rizzo S., Romagnoli D., Romano A., Rossi C., Rumi M. G., Russello M., Russo F. P., Russo M. L., Sansonno D. E., Santantonio T. A., Saracco G., Schimizzi A. M., Serviddio G., Simeone F., Solinas A., Soria A., Tabone M., Taliani G., Tarantino G., Tarquini P., Tavio M., Termite A., Teti E., Toniutto P., Torti C., Tundi P., Vecchiet G., Verucchi G., Gentilucci U. V., Vinci M., Vullo V., Zolfino T., and Zuin M.

Abstract

Purpose: To analyse safety and efficacy of treatment based on ombitasvir/paritaprevir/ritonavir/dasabuvir plus ribavirin in the sub-group of GT1 patients older than 65 years. Methods: We collected data extracted from the ABACUS compassionate-use nationwide Italian programme, in patients with cirrhosis due to hepatitis C virus (HCV) Genotype-1 (GT1) or 4 and at high risk of decompensation. GT1-HCV-infected patients received once-daily ombitasvir/paritaprevir, with the pharmacokinetic enhancer ritonavir (25/150/100 mg) and twice-daily dasabuvir (250 mg) plus Ribavirin (RBV) (OBV/PTV/r + DSV + RBV) for 12 (GT1b) or 24 (GT1a) weeks. Endpoints were to evaluate safety and efficacy, the latter defined as HCV RNA negative 12 weeks after the end of treatment (SVR12). Results: Patients who suffered any adverse event (AE) were 74/240 (30.8%); 13/240 (5.4%) discontinued the treatment. A multivariate analysis found albumin < 3.5 g/dL (OR 2.04: 95% CI 1.0–4.2, p < 0.05) and hypertension (OR 4.6: 95% CI 2.3–9.2, p < 0.001) as variables independently associated with AE occurrence. The SVR12 was 95% (228/240). Multivariate analysis identified baseline bilirubin < 2 mg/dL (OR 4.9: 95% CI 1.17–20.71, p = 0.029) as the only variable independently associated with SVR12. Conclusion: Our findings suggest that OBV/PTV/r + DSV + RBV is safe and effective in real-life use in patients with compensated cirrhosis, HCV-GT1 infection, and age over 65.

Published
2018

12. Impact of new DAA therapy on real clinical practice: a multicenter region-wide cohort study

Author

Lanini, Simone, Scognamiglio, Paola, Mecozzi, Alessandra, Lombardozzi, Lorella, Vullo, Vincenzo, Angelico, Mario, Gasbarrini, Antonio, Taliani, Gloria, Attili, Adolfo Francesco, Perno, Carlo Federico, De Santis, Adriano, Puro, Vincenzo, Cerqua, Fabio, D'Offizi, Gianpiero, Pellicelli, Adriano, Armignacco, Orlando, Mennini, Francesco Saverio, Siciliano, Massimo, Girardi, Enrico, Panella, Vincenzo, Ippolito, Giuseppe, Sarrecchia, C., Di Paolo, M. D., Francioso, S., Brega, A., Lenci, I., Sarmati, L., Pompili, Maurizio, Grieco, Antonio, Tamburrini, Enrica, Apaccini, R., Miele, Luca, D'Ettorre, G., Mezzaroma, I., Furlan, C., Accapezzato, D., Paoletti, F., Merili, M., Corradini, S., Sereno, S., Fimiani, C., Mastropietro, C., Labbadia, G., Gentile, Giuseppe, Pasquazzi, C., Marignani, M., Guarisco, R., Puoti, C., Spilabotti, L., Montalbano, M., Boumis, E., Visco-Comandini, U., Zaccarelli, M., Ammassari, A., Lionetti, R., Murachelli, S., Loiacono, L., Antinori, Armando, Noto, P., Palmieri, F., Cicalini, S., Cerilli, S., Sampaolesi, A., Vincenzi, L., Bellagamba, R., Galati, V., Abdeddaim, A., Iacomi, F., Iannicelli, G., Mastroianni, Chiara, Lichtner, M., Ridola, L., Coluzzi, T., Mercurio, V., Del Borgo, C., Fondacaro, L., Cerasari, G., Guarascio, P., D'Ambrosio, C., Starnini, G., Caterini, A., Villani, Emanuele Rocco, Sarracino, L., Casinelli, K., Moretti, A., Vespasiani, U., Galati, G., Cecere, R., Bonaventura, M., and Scudieri, M.

Subjects
Male, Cirrhosis, Investigational, chronic hepatitis c, clinical study, direct acting antiviral, hepatitis c virus, liver cirrhosis, liver damage, mixed effect model, multicenter cohort study, new therapy, treatment efficacy, Logistic regression, Chronic hepatitis C, Cohort Studies, 0302 clinical medicine, Clinical study, Direct acting antiviral, Hepatitis C virus, Liver cirrhosis, Liver damage, Mixed effect model, Multicenter cohort study, New therapy, Treatment efficacy, Adult, Aged, Aged, 80 and over, Antiviral Agents, Drug Therapy, Combination, Drugs, Investigational, Female, Follow-Up Studies, Hepatitis C, Chronic, Humans, Liver Cirrhosis, Middle Aged, Therapies, Investigational, 80 and over, 030212 general & internal medicine, Stage (cooking), Chronic, Confounding, Drugs, Hepatitis C, Infectious Diseases, Cohort, Combination, Settore SECS-P/03 - Scienza delle Finanze, 030211 gastroenterology & hepatology, Cohort study, Research Article, medicine.medical_specialty, Side effect, Hepatitis C virus, Chronic hepatitis C, Liver cirrhosis, Direct acting antiviral, Multicenter cohort study, Mixed effect model, Liver damage, Treatment efficacy, Clinical study, New therapy, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Drug Therapy, Internal medicine, medicine, lcsh:RC109-216, business.industry, Settore MED/09 - MEDICINA INTERNA, medicine.disease, Clinical trial, Therapies, business
Abstract

Background Management of chronic hepatitis C (CHC) has significantly accelerated in the last few years. Currently, second generation direct acting antivirals (DAAs) promise clearance of infection in most of patients. Here we present the results of the first analysis carried out on data of Lazio clinical network for DAAs. Methods The study was designed as a multicenter cohort: a) to assess the evolution of treatment during the first 24 months of the activity of the Clinical Network; b) to report overall efficacy of treatments; c) to analyze potential factors associated with lack of virological response at 12 weeks after therapy (SVR12); d) to evaluate the variation of ALT at baseline and 12 weeks after therapy in those who achieved SVR12 in comparison to those who did not. Analyses of efficacy were carried out with multilevel mixed effect logistic regression model. ALT temporal variation was assessed by mixed effect model mixed models with random intercept at patient’s level and random slope at the level of the time; i.e. either before or after therapy. Results Between 30 December 2014 and 31 December 2016 5279 patients started a DAA treatment; of those, 5127 (in 14 clinical centers) had completed the 12-week follow-up. Overall proportion of SVR12 was 93.41% (N = 4780) with no heterogeneity between the 14 clinical centers. Interruption as the consequence of severe side effect was very low (only 23 patients). Unadjusted analysis indicates that proportion of SVR12 significantly changes according to patient’s baseline characteristics, however after adjusting for potential confounders only adherence to current guidelines, stage of liver diseases, gender, transplant and HIV status were independently associated with the response to therapy. Analysis of ALT temporal variation showed that ALT level normalized in most, but not, all patients who achieved SVR12. Conclusion Our study confirmed the extraordinary efficacy of DAAs outside clinical trials. The advantage of DAAs was particularly significant for those patients who were previously considered as difficult-to-treat and did not have treatment options before DAAs era. Intervention based on network of select centers and prioritization of patients according to diseases severity was successful. Further studies are needed to establish whether clearance of HCV after DAAs therapy can arrest or even revert liver fibrosis in non-cirrhotic patients and/or improve life quality and expectancy in those who achieve SVR12 with cirrhosis.

Published
2018
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15. THE ESSENTIAL FRAILTY TOOLSET IN OLDER ADULTS UNDERGOING ISOLATED CABG

Author

Solomon, J., primary, Moss, E., additional, Morin, J., additional, Langlois, Y., additional, Joyal, D., additional, Lachapelle, K., additional, Ma, F., additional, Cecere, R., additional, De Varennes, B., additional, Bendayan, M., additional, Piankova, P., additional, Hayman, V., additional, Ouimet, M., additional, McNamara, S., additional, Rudski, L., additional, and Afilalo, J., additional

Published
2020
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22. The impact of the law in the prevention of FGM

Author

Richard, F, Ahmed, W, Denholm, N, Dawson, A, Varol, N, Essén, B, Johnsdotter, S, Bukuluki, P, Naeema, A, Eltayeb, D, Shell-Duncan, B, Njue, C, Muteshi, J, Lamy, C, Neyrinck, P, Verduyckt, P, Alexander, S, Kimani, S, Esho, T, Kimani, V, Kigondu, C, Karanja, J, Guyo, J, Touré, M, Guindo, Y, Samaké, D, Camara, L, Traoré, Y, Traoré, A, Samaké, A, Johnson-Agbakwu, C, Jordal, M, Jirovsky, E, Wu, S, Fitzgerald, K, Mishori, R, Reingold, R, Ismail, E, Say, L, Uebelhart, M, Boulvain, M, Dallenbäch, P, Irion, O, Petignat, P, Abdulcadir, J, Farina, P, Leye, E, Ortensi, L, Pecorella, C, Novak, L, Cuzin, B, Delmas, F, Papingui, A, Bader, D, Wahlberg, A, Selling, K, Källestål, C, Ibraheim, A, Elawad, N, Gasseer, A, Naeema, H, Maison, E, Hussein, H, Albagir, A, Albirair, M, Salih, S, Muniu, S, Nyamongo, I, Ndavi, P, Hedley, H, Kuenzi, R, Malavé-Seda, L, Clare, C, Greenfield, J, Augustus, P, Ukatu, N, Manu, E, Altonen, B, Caillet, M, Foldès, P, Wylomanski, S, Vital, M, De Visme, S, Dugast, S, Hanf, M, Winer, N, Seifeldin, A, Villani, M, Seinfeld, R, Earp, B, Cappon, S, L’Ecluse, C, Clays, E, Tency, I, Johansen, R, Ouédraogo, C, Madzou, S, Simporé, A, Combaud, V, Ouattara, A, Millogo, F, Ouédraogo, A, Kiemtore, S, Zamane, H, Sawadogo, Y, Kaien, P, Dramé, B, Thieba, B, Lankoandé, J, Descamps, P, Catania, L, Mastrullo, R, Caselli, A, Cecere, R, Abdulcadir, O, Vogt, S, Efferson, C, O’Neill, S, Dubour, D, Florquin, S, Bos, M, Zewolde, S, Turkmani, S, Hall, J, Nanayakkara, S, Jenkins, G, Homer, C, Mcgeechan, K, de Visme, S, Philippe, H, Warren, N, Macfarlane, A, Dorkenoo, W, Lien, I, Schultz, J, FARINA, PATRIZIA, ORTENSI, LIVIA ELISA, PECORELLA, CLAUDIA, Richard, F, Ahmed, W, Denholm, N, Dawson, A, Varol, N, Essén, B, Johnsdotter, S, Bukuluki, P, Naeema, A, Eltayeb, D, Shell-Duncan, B, Njue, C, Muteshi, J, Lamy, C, Neyrinck, P, Verduyckt, P, Alexander, S, Kimani, S, Esho, T, Kimani, V, Kigondu, C, Karanja, J, Guyo, J, Touré, M, Guindo, Y, Samaké, D, Camara, L, Traoré, Y, Traoré, A, Samaké, A, Johnson-Agbakwu, C, Jordal, M, Jirovsky, E, Wu, S, Fitzgerald, K, Mishori, R, Reingold, R, Ismail, E, Say, L, Uebelhart, M, Boulvain, M, Dallenbäch, P, Irion, O, Petignat, P, Abdulcadir, J, Farina, P, Leye, E, Ortensi, L, Pecorella, C, Novak, L, Cuzin, B, Delmas, F, Papingui, A, Bader, D, Wahlberg, A, Selling, K, Källestål, C, Ibraheim, A, Elawad, N, Gasseer, A, Naeema, H, Maison, E, Hussein, H, Albagir, A, Albirair, M, Salih, S, Muniu, S, Nyamongo, I, Ndavi, P, Hedley, H, Kuenzi, R, Malavé-Seda, L, Clare, C, Greenfield, J, Augustus, P, Ukatu, N, Manu, E, Altonen, B, Caillet, M, Foldès, P, Wylomanski, S, Vital, M, De Visme, S, Dugast, S, Hanf, M, Winer, N, Seifeldin, A, Villani, M, Seinfeld, R, Earp, B, Cappon, S, L’Ecluse, C, Clays, E, Tency, I, Johansen, R, Ouédraogo, C, Madzou, S, Simporé, A, Combaud, V, Ouattara, A, Millogo, F, Ouédraogo, A, Kiemtore, S, Zamane, H, Sawadogo, Y, Kaien, P, Dramé, B, Thieba, B, Lankoandé, J, Descamps, P, Catania, L, Mastrullo, R, Caselli, A, Cecere, R, Abdulcadir, O, Vogt, S, Efferson, C, O’Neill, S, Dubour, D, Florquin, S, Bos, M, Zewolde, S, Turkmani, S, Hall, J, Nanayakkara, S, Jenkins, G, Homer, C, Mcgeechan, K, de Visme, S, Philippe, H, Warren, N, Macfarlane, A, Dorkenoo, W, Lien, I, Schultz, J, FARINA, PATRIZIA, ORTENSI, LIVIA ELISA, and PECORELLA, CLAUDIA

Published
2017

26. Female Genital Mutilation/Cutting: sharing data and experiences to accelerate eradication and improve care: part 2

Author

Richard, Fabienne, primary, Ahmed, Wisal, additional, Denholm, Nikki, additional, Dawson, Angela, additional, Varol, Nesrin, additional, Essén, Birgitta, additional, Johnsdotter, Sara, additional, Bukuluki, Paul, additional, Naeema, Al Gasseer H., additional, eltayeb, Dalya, additional, Shell-Duncan, Bettina, additional, Njue, Caroline, additional, Muteshi, Jacinta, additional, Lamy, Clotilde, additional, Neyrinck, Pascale, additional, Richard, Fabienne, additional, Verduyckt, Peter, additional, Alexander, Sophie, additional, Kimani, Samuel, additional, Esho, Tammary, additional, Kimani, Violet, additional, Kigondu, Christine, additional, Karanja, Joseph, additional, Guyo, Jaldesa, additional, Touré, Moustapha, additional, Guindo, Yacin Gackou, additional, Samaké, Dramane, additional, Camara, Ladji, additional, Traoré, Youssouf, additional, Traoré, Alassane A., additional, Samaké, Alou, additional, Johnson-Agbakwu, Crista E., additional, Jordal, Malin, additional, Jirovsky, Elena, additional, Wu, Samantha, additional, Fitzgerald, Kevin, additional, Mishori, Ranit, additional, Reingold, Rebecca, additional, Ismail, Edna Adan, additional, Say, Lale, additional, Uebelhart, Marion, additional, Boulvain, Michel, additional, Dallenbäch, Patrick, additional, Irion, Olivier, additional, Petignat, Patrick, additional, Abdulcadir, Jasmine, additional, Farina, Patrizia, additional, Leye, Els, additional, Ortensi, Livia, additional, Pecorella, Claudia, additional, Novak, Lindsey, additional, Cuzin, Béatrice, additional, Delmas, Florence Brunel, additional, Papingui, Albertine, additional, Bader, Dina, additional, Wahlberg, Anna, additional, Selling, Katarina Ekholm, additional, Källestål, Carina, additional, Ibraheim, Abdalla Hisham Hussein Imam, additional, Elawad, Nasr A. M., additional, Gasseer, Al, additional, Naeema, H., additional, Maison, Elamin, additional, Hussein, Hiba, additional, Albagir, Altayyeb Mohammed, additional, Albirair, Mohamed Tawfig, additional, Salih, Sarah A. Salam, additional, Muniu, Samuel, additional, Nyamongo, Isaac, additional, Ndavi, Patrick, additional, Hedley, Holly, additional, Kuenzi, Rachel, additional, Malavé-Seda, Laura, additional, Clare, Camille, additional, Greenfield, Jacqueline, additional, Augustus, Praise, additional, Ukatu, Nneamaka, additional, Manu, Eugene, additional, Altonen, Brian, additional, Caillet, Martin, additional, Foldès, Pierre, additional, Wylomanski, Sophie, additional, Vital, Mathilde, additional, De Visme, Sophie, additional, Dugast, Stéphanie, additional, Hanf, Matthieu, additional, Winer, Norbert, additional, Seifeldin, Amr, additional, Villani, Michela, additional, Seinfeld, Rebecca, additional, Earp, Brian, additional, Cappon, S., additional, L’Ecluse, C., additional, Clays, E., additional, Tency, I., additional, Leye, E., additional, Johansen, R. E., additional, Ouédraogo, C. M., additional, Madzou, S., additional, Simporé, A., additional, Combaud, V., additional, Ouattara, A., additional, Millogo, F., additional, Ouédraogo, A., additional, Kiemtore, S., additional, Zamane, H., additional, Sawadogo, Y. A., additional, Kaien, P., additional, Dramé, B., additional, Thieba, B., additional, Lankoandé, J., additional, Descamps, P., additional, Catania, L., additional, Mastrullo, R., additional, Caselli, A., additional, Cecere, R., additional, Abdulcadir, O., additional, Abdulcadir, J., additional, Vogt, Sonja, additional, Efferson, Charles, additional, O’Neill, S., additional, Dubour, D., additional, Florquin, S., additional, Bos, M., additional, Zewolde, S., additional, Richard, F., additional, Varol, N., additional, Dawson, A., additional, Turkmani, S., additional, Hall, J. J., additional, Nanayakkara, S., additional, Jenkins, G., additional, Homer, C. S., additional, McGeechan, K., additional, Vital, M., additional, de Visme, S., additional, Hanf, M., additional, Philippe, H. J., additional, Winer, N., additional, Wylomanski, S., additional, Johnson-Agbakwu, C., additional, Warren, N., additional, Macfarlane, A., additional, Dorkenoo, W., additional, Lien, I. L., additional, and Schultz, J. H., additional

Published
2017
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27. Pregnancy After Heart Transplantation: A Well-Thought-Out Decision?

Author

Dagher, O., primary, Laroussi, N., additional, Cantin, B., additional, Carrier, M., additional, Cecere, R., additional, Charbonneau, E., additional, De Denus, S., additional, Giannetti, N., additional, Leduc, L., additional, Levesque, S., additional, Poirier, N., additional, Raboisson, M., additional, White, M., additional, and Ducharme, A., additional

Published
2017
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28. Individuation of presence and combination of genetic risk factors may help to refine the risk for most severe forms of NAFLD

Author

Vespasiani-Gentilucci, U., primary, Dell’Unto, C., additional, Vorini, F., additional, Monache, M.D., additional, Cecere, R., additional, Francia, C., additional, Cerini, F., additional, Galati, G., additional, Gallo, P., additional, De Vincentis, A., additional, Pellicelli, A.M., additional, Baiocchini, A., additional, and Picardi, A., additional

Published
2017
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29. Unseen fearful faces influence face encoding

Author

BERTINI, CATERINA, LADAVAS, ELISABETTA, Cecere R, Maier M, Bertini C, Cecere R, Maier M, and Ladavas E

Subjects
genetic structures, BLINDSIGHT, HEMIANOPIA, FEAR
Abstract

Threat-related signals are processed not only via striatal cortical areas, but also via a subcortical colliculo-pulvinar-amydala pathway, which presumably mediates implicit processing of fearful stimuli. To investigate the role of implicit fear processing mediated by the subcortical pathway at the early stages of facial encoding, we examined the ERPs elicited by fearful and happy faces presented to the intact visual field of right and left hemianopic patients, while fearful, happy or neutral faces were concurrently presented in their blind field. The results showed that in patients with lesions to the left hemisphere, the N170 amplitude was significantly increased only when a fearful face was presented in the blind visual field concurrently with a happy face in the intact visual field. This enhancement of facial encoding suggests a specialization of the subcortical pathway in processing unseen fearful stimuli. In addition, the lack of modulation with concurrent seen fearful faces reveal that the conscious perception of fear might inhibit the activation of the subcortical pathway. The modulation was only observed in patients with left hemisphere lesions, which favors the hypothesis that implicit processing of fearful signals (mediated by the subcortical pathway) is possible only when the right hemisphere is intact.

Published
2013

34. EVOLUTION IN THE USE OF LONG-TERM LEFT VENTRICULAR ASSIST DEVICES IN QUÉBEC: 2010-12 VERSUS 2013-15 AND COMPARISON WITH THE INTERMACS REGISTRY

Author

Lambert, L.J., primary, Ducharme, A., additional, Azzi, L., additional, Sas, G., additional, Charbonneau, E., additional, Cecere, R., additional, Gauthier, M., additional, Giannetti, N., additional, Racine, N., additional, Stanbridge, D., additional, Bourgault, C., additional, Carrier, M., additional, Afilalo, J., additional, Sanscartier, C., additional, and Bogaty, P., additional

Published
2016
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42. Treatment outcomes and relapses of pulmonary tuberculosis in Lazio, Italy, 1999-2001: a six-year follow-up study

Author

Faustini, A., Hall, A. J., Mantovani, J., Sangalli, M., Perucci, C. A., Ciardi, M., Iaiani, G., Mastroianni, C., Mastropietro, C., Teggi, A., Cauda, R., Cingolani, A., Di Giambenedetto, S., Saltini, C., Bocchino, M., De Marco, M., Ghirba, P., Grisetti, S., Palmieri, F., Rianda, A., Traversa, M., Alma, M., Antonelli, F., Pugliesi, G., Olivieri, M., Rossi, A., Sanguinetti, M., Simeoni, I., Pandolfi, A., Bologna, E., Carrescia, M., Alimenti, P., Cantero, M., Ticca, F., Lancella, L., Dainotto, D., Geraci, S., Anzalone, E., Buratti, A. R., Zanini, R., Signore, A., Goretti, S. M., Munafo, G., Autore, F., Pitorri, A., Le Donne, R., Armignaco, A., Bernardini, G., Fiorani, C. M., Di Michele, L., De Padova, F., Manenti, M., Runci, G., Rossi, P., Aquilani, S., Cecere, R., Ercole, A., Esterini, G., Gallo, L., Gnesivo, C., Guadagnali, R., Labriola, V., Loffredo, M. R., Pasqualitto, P., Patti, P., Porcelli, P., Tanzariello, E., Cauda R. (ORCID:0000-0002-1498-4229), Cingolani A. (ORCID:0000-0002-3793-2755), Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Sanguinetti M. (ORCID:0000-0002-9780-7059), Faustini, A., Hall, A. J., Mantovani, J., Sangalli, M., Perucci, C. A., Ciardi, M., Iaiani, G., Mastroianni, C., Mastropietro, C., Teggi, A., Cauda, R., Cingolani, A., Di Giambenedetto, S., Saltini, C., Bocchino, M., De Marco, M., Ghirba, P., Grisetti, S., Palmieri, F., Rianda, A., Traversa, M., Alma, M., Antonelli, F., Pugliesi, G., Olivieri, M., Rossi, A., Sanguinetti, M., Simeoni, I., Pandolfi, A., Bologna, E., Carrescia, M., Alimenti, P., Cantero, M., Ticca, F., Lancella, L., Dainotto, D., Geraci, S., Anzalone, E., Buratti, A. R., Zanini, R., Signore, A., Goretti, S. M., Munafo, G., Autore, F., Pitorri, A., Le Donne, R., Armignaco, A., Bernardini, G., Fiorani, C. M., Di Michele, L., De Padova, F., Manenti, M., Runci, G., Rossi, P., Aquilani, S., Cecere, R., Ercole, A., Esterini, G., Gallo, L., Gnesivo, C., Guadagnali, R., Labriola, V., Loffredo, M. R., Pasqualitto, P., Patti, P., Porcelli, P., Tanzariello, E., Cauda R. (ORCID:0000-0002-1498-4229), Cingolani A. (ORCID:0000-0002-3793-2755), Di Giambenedetto S. (ORCID:0000-0001-6990-5076), and Sanguinetti M. (ORCID:0000-0002-9780-7059)

Abstract

Objectives: The aim of this study was to enhance tuberculosis (TB) treatment outcome monitoring by linking diverse surveillance systems and estimating treatment outcomes including relapse. Methods: Tuberculosis treatment was surveyed in the Lazio region (Italy) from 1999 to 2001; a six-year follow-up of notified cases was undertaken to detect relapses. The results were analyzed as a population-based case-control study comparing each unsuccessful outcome and relapse with eligible controls. Results: Of the 974 patients who entered the survey, 805 (82.6%) had complete treatment evaluations; 398 (49.4%) had a successful outcome, 401 (49.8%) had an unsuccessful outcome, and six developed chronic TB. Death was associated with age >64 years (OR 5.9; 95% CI 3.1-11.2), male gender (OR 2.1; 95% CI 1.0-4.4), and using second-line drugs (OR 2.3; 95% CI 1.0-5.4). Treatment failure was associated with previous treatment (OR 3.0; 95% CI 1.4-6.7) and being male, being foreign born (OR 6.6; 95% CI 2.1-21.2), receiving second-line drugs (OR 7.4; 95% CI 1.8-29.5), and receiving modified therapy (OR 5.1; 95% CI 1.7-14.9). Relapses after successful outcomes were detected in 5.5%, for which the strongest predictor was having extrapulmonary lesions (OR 22.8; 95% CI 1.8-287.3). Conclusions: Linking our survey data to other surveillance systems improved the mortality estimates and detected a high rate of relapse. Having received previous treatment and being a foreigner were independent determinants of treatment failure, suggesting that both acquired and primary drug resistance affect TB patients in Lazio. © 2008 International Society for Infectious Diseases.

Published
2008

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