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Your search keyword '"Cebulska-Wasilewska, Antonina"' showing total 37 results
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37 results on '"Cebulska-Wasilewska, Antonina"'

11. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans

Author

Bonassi, Stefano, Znaor, Ariana, Ceppi, Marcello, Lando, Cecilia, Chang, Wushou Peter, Holland, Nina, Kirsch-Volders, Micheline, Zeiger, Errol, Ban, Sadayuki, Barale, Roberto, Bigatti, Maria Paola, Bolognesi, Claudia, Cebulska-Wasilewska, Antonina, Fabianova, Eleonora, Fucic, Alexandra, Hagmar, Lars, Joksic, Gordana, Martelli, Antonietta, Migliore, Lucia, Mirkova, Ekaterina, Scarfi, Maria Rosaria, Zijno, Andrea, Norppa, Hannu, and Fenech, Michael

Published
2007

26. Chromosomal aberration frequency in lymphocytes predicts the risk of cancer:results from a pooled cohort study of 22 358 subjects in 11 countries

Author

Bonassi, Stefano, Norppa, Hannu, Ceppi, Marcello, Strömberg, Ulf, Vermeulen, Roel, Znaor, Ariana, Cebulska-Wasilewska, Antonina, Fabianova, Eleonora, Fucic, Alexandra, Gundy, Sarolta, Hansteen, Inger-Lise, Knudsen, Lisbeth E., Lazutka, Juozas, Rossner, Pavel, Sram, Radim J, Boffetta, Paolo, Bonassi, Stefano, Norppa, Hannu, Ceppi, Marcello, Strömberg, Ulf, Vermeulen, Roel, Znaor, Ariana, Cebulska-Wasilewska, Antonina, Fabianova, Eleonora, Fucic, Alexandra, Gundy, Sarolta, Hansteen, Inger-Lise, Knudsen, Lisbeth E., Lazutka, Juozas, Rossner, Pavel, Sram, Radim J, and Boffetta, Paolo

Abstract

Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association, a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22 358 cancer-free individuals who underwent genetic screening with CA for biomonitoring purposes during 1965-2002 and were followed up for cancer incidence and/or mortality for an average of 10.1 years; 368 cancer deaths and 675 incident cancer cases were observed. Subjects were classified within each laboratory according to tertiles of CA frequency. The relative risk (RR) of cancer was increased for subjects in the medium [RR = 1.31, 95% confidence interval (CI) = 1.07-1.60] and in the high (RR = 1.41; 95% CI = 1.16-1.72) tertiles when compared with the low tertile. This increase was mostly driven by chromosome-type aberrations. The presence of ring chromosomes increased the RR to 2.22 (95% CI = 1.34-3.68). The strongest association was found for stomach cancer [RR(medium) = 1.17 (95% CI = 0.37-3.70), RR(high) = 3.13 (95% CI = 1.17-8.39)]. Exposure to carcinogens did not modify the effect of CA levels on overall cancer risk. These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type.

Published
2008

37. [Influence of mercury vapors on lymphocytes in vivo and on their susceptibility to UV-C and X-rays, and repair efficiency in vitro].

Author

Cebulska-Wasilewska A, Panek A, Zabiński Z, and Moszczyński P

Subjects
Adult, Humans, In Vitro Techniques, Inhalation Exposure, Male, Middle Aged, Occupational Exposure, Poland, Sister Chromatid Exchange drug effects, DNA Repair drug effects, DNA Repair radiation effects, Lymphocytes drug effects, Lymphocytes radiation effects, Mercury Poisoning, Ultraviolet Rays adverse effects, X-Rays adverse effects
Abstract

Background: The aim of the study was to compare the levels of DNA and cytogenetic damage in lymphocytes from donors occupationally exposed to mercury vapors and from matched controls as well as their cellular susceptibility to radiation and capabilities to repair DNA damage induced by UV-C or X-ray exposures in vitro., Materials and Methods: To estimate cytogenetic damage, the analysis of sister chromatid exchange frequency (SCE) was used, and to detect DNA damage the alkaline version of single cell gel electrophoresis (SCGE) was applied. To analyze cellular susceptibility, lymphocytes were exposed to 6 J/m2 of UV-C or irradiated with 2 Gy of X-rays. After challenging exposures, cells were incubated for 2 h with or without the presence of cellular mitogen (phytohemagglutinin--PHA)., Results and Conclusions: The study did not show statistically significant differences either between the groups, levels of DNA damage (measured as the percentage of cells with comets or comet tail moments), or sister chromatid exchanges. Neither were there significant differences in the levels of DNA damage (measured as tail moment and comet length) detected in UV-C exposed lymphocytes after 2 h incubation in the presence or in the absence of PHA stimulating cells and in the susceptibility to X-ray radiation of lymphocytes between the groups of non-exposed persons and those occupationally exposed to mercury vapors. In the group exposed to mercury vapors, however, statistically significantly higher levels of non-repaired DNA damage measured in X-ray irradiated lymphocytes after 2 h of incubation, with or without the presence of mitogen were observed compared to controls. Significant differences were observed in all types of DNA damage measures (comet tail length, % of DNA, in the comet and comet tail moments). As a result, lymphocytes of donors exposed to mercury vapors showed a statistically lower repair efficiency of X-ray-induced DNA damage both in non-stimulated (70.0% for the exposed, 85.7% for the non-exposed) and stimulated (84.0% for the exposed and 90.4% for the non-exposed) lymphocytes. Cellular DNA repair efficiency decreased with increasing number of years of occupational exposure. Statistically significant DNA repair deficiency in the donors exposed to mercury vapors was also observed when the groups were stratified to smokers and non-smokers.

Published
2005

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