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1. Automatic lesion analysis for increased efficiency in outcome prediction of traumatic brain injury

Author

Rosnati, Margherita, Soreq, Eyal, Monteiro, Miguel, Li, Lucia, Graham, Neil S. N., Zimmerman, Karl, Rossi, Carlotta, Carrara, Greta, Bertolini, Guido, Sharp, David J., and Glocker, Ben

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

The accurate prognosis for traumatic brain injury (TBI) patients is difficult yet essential to inform therapy, patient management, and long-term after-care. Patient characteristics such as age, motor and pupil responsiveness, hypoxia and hypotension, and radiological findings on computed tomography (CT), have been identified as important variables for TBI outcome prediction. CT is the acute imaging modality of choice in clinical practice because of its acquisition speed and widespread availability. However, this modality is mainly used for qualitative and semi-quantitative assessment, such as the Marshall scoring system, which is prone to subjectivity and human errors. This work explores the predictive power of imaging biomarkers extracted from routinely-acquired hospital admission CT scans using a state-of-the-art, deep learning TBI lesion segmentation method. We use lesion volumes and corresponding lesion statistics as inputs for an extended TBI outcome prediction model. We compare the predictive power of our proposed features to the Marshall score, independently and when paired with classic TBI biomarkers. We find that automatically extracted quantitative CT features perform similarly or better than the Marshall score in predicting unfavourable TBI outcomes. Leveraging automatic atlas alignment, we also identify frontal extra-axial lesions as important indicators of poor outcome. Our work may contribute to a better understanding of TBI, and provides new insights into how automated neuroimaging analysis can be used to improve prognostication after TBI., Comment: Accepted at MLCN MICCAI 2022 workshop

Published
2022

2. Development of a Prediction Model for COVID‐19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases: Results From the Global Rheumatology Alliance Registry

Author

Izadi, Zara, Gianfrancesco, Milena A, Aguirre, Alfredo, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson‐Tovey, Saskia, Kearsley‐Fleet, Lianne, Schaefer, Martin, Seet, Andrea M, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Al‐Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y‐T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte‐García, Alí, Valenzuela‐Almada, Maria O, Ugarte‐Gil, Manuel F, Ribeiro, Sandra Lúcia Euzébio, de Oliveira Marinho, Adriana, de Azevedo Valadares, Lilian David, Di Giuseppe, Daniela, Hasseli, Rebecca, Richter, Jutta G, Pfeil, Alexander, Schmeiser, Tim, Isnardi, Carolina A, Torres, Alvaro A Reyes, Alle, Gelsomina, Saurit, Verónica, Zanetti, Anna, Carrara, Greta, Labreuche, Julien, Barnetche, Thomas, Herasse, Muriel, Plassart, Samira, Santos, Maria José, Rodrigues, Ana Maria, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Costello, Wendy, Wallace, Zachary S, Yazdany, Jinoos, and Registry, Global Rheumatology Alliance

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Prevention, Rare Diseases, Arthritis, Autoimmune Disease, Good Health and Well Being, Global Rheumatology Alliance Registry, Clinical sciences
Abstract

ObjectiveSome patients with rheumatic diseases might be at higher risk for coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS). We aimed to develop a prediction model for COVID-19 ARDS in this population and to create a simple risk score calculator for use in clinical settings.MethodsData were derived from the COVID-19 Global Rheumatology Alliance Registry from March 24, 2020, to May 12, 2021. Seven machine learning classifiers were trained on ARDS outcomes using 83 variables obtained at COVID-19 diagnosis. Predictive performance was assessed in a US test set and was validated in patients from four countries with independent registries using area under the curve (AUC), accuracy, sensitivity, and specificity. A simple risk score calculator was developed using a regression model incorporating the most influential predictors from the best performing classifier.ResultsThe study included 8633 patients from 74 countries, of whom 523 (6%) had ARDS. Gradient boosting had the highest mean AUC (0.78; 95% confidence interval [CI]: 0.67-0.88) and was considered the top performing classifier. Ten predictors were identified as key risk factors and were included in a regression model. The regression model that predicted ARDS with 71% (95% CI: 61%-83%) sensitivity in the test set, and with sensitivities ranging from 61% to 80% in countries with independent registries, was used to develop the risk score calculator.ConclusionWe were able to predict ARDS with good sensitivity using information readily available at COVID-19 diagnosis. The proposed risk score calculator has the potential to guide risk stratification for treatments, such as monoclonal antibodies, that have potential to reduce COVID-19 disease progression.

Published
2022

3. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Izadi, Zara, Gianfrancesco, Milena A, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Ja, Clairissa, Taylor, Tiffany, Shidara, Kie, Danila, Maria I, Wysham, Katherine D, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O, Ugarte-Gil, Manuel F, Ljung, Lotta, Scirè, Carlo A, Carrara, Greta, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Thomas, Thierry, Santos, Maria J, Bernardes, Miguel, Hasseli, Rebecca, Regierer, Anne, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Pons-Estel, Guillermo, Tanten, Romina, Nieto, Romina E, Pisoni, Cecilia N, Tissera, Yohana S, Xavier, Ricardo, Marques, Claudia D Lopes, Pileggi, Gecilmara CS, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Gore-Massy, Monique, Wallace, Zachary S, Yazdany, Jinoos, Registry, COVID-19 Global Rheumatology Alliance, Dahou, Brahim, Gómez, Gimena, Roberts, Karen, Baez, Roberto M, Coello, Vanessa V Castro, Salinas, María J Haye, Maldonado, Federico N, Reyes, Alvaro A, Alle, Gelsomina, Ficco, Hernán Maldonado, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan A, Schmid, Maria M, Cosatti, Micaela, Gamba, Maria J, Leandro, Carlevaris, Cusa, María A, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Elkin, Maria S Gálvez, Medina, María A, Savio, Veronica, Tessel, Romina Rojas, Alamino, Rodolfo P, Werner, Marina L, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, and Lucero, Luciana Gonzalez

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Women's Health, Social Determinants of Health, Infectious Diseases, Coronaviruses, Emerging Infectious Diseases, Good Health and Well Being, COVID-19 Global Rheumatology Alliance Registry, Clinical sciences
Abstract

BackgroundDifferences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally.MethodsIn this observational study, we derived individual-level data on adults (aged 18-99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death.Findings14 044 patients from 23 countries were included in the analyses. 10 178 (72·5%) individuals were female and 3866 (27·5%) were male, with a mean age of 54·4 years (SD 15·6). Air pollution (odds ratio 1·10 per 10 μg/m3 [95% CI 1·01-1·17]; p=0·0105), proportion of the population aged 65 years or older (1·19 per 1% increase [1·10-1·30]; p

Published
2022

4. QFR for the Revascularization of Nonculprit Vessels in MI Patients: Insights From the FIRE Trial

Author

Erriquez, Andrea, Campo, Gianluca, Guiducci, Vincenzo, Casella, Gianni, Menozzi, Mila, Cerrato, Enrico, Sacchetta, Giorgio, Moreno, Raul, Arena, Marco, Amat Santos, Ignacio, Diez Gil, Jose Luis, Scarsini, Roberto, Ruozzi, Marco, Arioti, Manfredi, Picchi, Andrea, Barbierato, Marco, Moscarella, Elisabetta, Musto D’Amore, Sergio, Lanzilotti, Valerio, Cavazza, Caterina, Rezzaghi, Marco, Cocco, Marta, Marrone, Andrea, Verardi, Filippo Maria, Escaned, Javier, Barbato, Emanuele, Colaiori, Iginio, Pesenti, Nicola, Carrara, Greta, and Biscaglia, Simone

Published
2024
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5. Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry

Author

Yazdany, Jinoos, Ware, Anna, Wallace, Zachary S., Bhana, Suleman, Grainger, Rebecca, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Hausmann, Jonathan S., Liew, Jean W., Sirotich, Emily, Jacobsohn, Lindsay, Strangfeld, Anja, Mateus, Elsa F., Hyrich, Kimme L., Gossec, Laure, Carmona, Loreto, Lawson‐Tovey, Saskia, Kearsley‐Fleet, Lianne, Schaefer, Martin, Ribeiro, Sandra Lucia Euzebio, Al‐Emadi, Samar, Hasseli, Rebecca, Müller‐Ladner, Ulf, Specker, Christof, Schulze‐Koops, Hendrik, Bernardes, Miguel, Fraga, Vanessa Machado, Rodrigues, Ana Maria, Sparks, Jeffrey A., Ljung, Lotta, Di Giuseppe, Daniela, Tidblad, Liselotte, Wise, Leanna, Duarte‐García, Alí, Ugarte‐Gil, Manuel F., Colunga‐Pedraza, Iris Jazmín, Martínez‐Martínez, Marco Ulises, Alpizar‐Rodriguez, Deshire, Xavier, Ricardo Machado, Isnardi, Carolina A., Pera, Mariana, Pons‐Estel, Guillermo, Izadi, Zara, Gianfrancesco, Milena A., Carrara, Greta, Scirè, Carlo Alberto, Zanetti, Anna, and Machado, Pedro M.

Published
2024
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6. Rationale and design of the PARTHENOPE trial: A two-by-two factorial comparison of polymer-free vs biodegradable-polymer drug-eluting stents and personalized vs standard duration of dual antiplatelet therapy in all-comers undergoing PCI

Author

Piccolo, Raffaele, Calabrò, Paolo, Varricchio, Attilio, Baldi, Cesare, Napolitano, Giovanni, De Simone, Ciro, Mauro, Ciro, Stabile, Eugenio, Caiazzo, Gianluca, Tesorio, Tullio, Boccalatte, Marco, Tuccillo, Bernardino, Bottiglieri, Giuseppe, Russolillo, Enrico, Di Lorenzo, Emilio, Carrara, Greta, Cassese, Salvatore, Leonardi, Sergio, Biscaglia, Simone, Costa, Francesco, McFadden, Eugene, Heg, Dik, Franzone, Anna, Stefanini, Giulio G., Capodanno, Davide, and Esposito, Giovanni

Published
2023
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7. Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. The experience of the Italian SIR-SPRING registry and review of the world literature

Author

Ferri, Clodoveo, De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia, Cavazzana, Ilaria, Ingegnoli, Francesca, De Santis, Maria, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Lazzaroni, Maria Grazia, Franceschini, Franco, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Mariano, Giuseppa Pagano, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, and Matucci-Cerinic, Marco

Published
2022
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8. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Dahou, Brahim, Gómez, Gimena, Roberts, Karen, Baez, Roberto M, Castro Coello, Vanessa V, Haye Salinas, María J, Maldonado, Federico N, Reyes, Alvaro A, Alle, Gelsomina, Tanten, Romina, Maldonado Ficco, Hernán, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan A, Schmid, Maria M, Cosatti, Micaela, Gamba, Maria J, Leandro, Carlevaris, Cusa, María A, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Gálvez Elkin, Maria S, Medina, María A, Savio, Veronica, Rojas Tessel, Romina, Alamino, Rodolfo P, Werner, Marina L, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, Gonzalez Lucero, Luciana, Romeo, Cecilia, Moyano, Sebastián, Barbich, Tatiana, Bertoli, Ana, Baños, Andrea, Petruzzelli, Sandra, Matellan, Carla, Conti, Silvana, Lazaro, Maria A, Rodriguez Gil, Gustavo F, Risueño, Fabian, Quaglia, Maria I, Scafati, Julia, Cuchiaro, Natalia L, Rebak, Jonathan E, Pineda, Susana I, Calvo, María E, Picco, Eugenia, Yanzi, Josefina G, Maid, Pablo, Guaglianone, Debora, Morbiducci, Julieta S, Porta, Sabrina, Herscovich, Natalia, Velasco Zamora, José L, Kisluk, Boris, Castaños Menescardi, Maria S, Gallo, Rosana, Martire, María V, Maldini, Carla, Goizueta, Cecilia, de la Vega Fernandez, Sabrina S, Aeschlimann, Carolina, Subils, Gisela, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Machado Ribeiro, Francinne, Euzebio Ribeiro, Sandra L, Pinheiro, Marcelo, Ibáñez, Sebastián, Chassin Trubert, Anne-Marie, Dong, Lingli, Cajas, Lui, Barešić, Marko, Anić, Branimir, Ćulo, Melanie-Ivana, Pavelić, Tea A, Stranski, Kristina K, Karanovic, Boris, Vencovsky, Jiri, Píchová, Marta, Filkova, Maria, Hamoud, Hesham, Vassilopoulos, Dimitrios, Guzman Melgar, Gabriela M, So, Ho, Király, Márta, Vojdanian, Mahdi, Balbir Gurman, Alexandra, Abutiban, Fatemah, Zepa, Julija, Bulina, Inita, Bukauskiene, Loreta, Zazueta Montiel, Beatriz E, Castillo Ortiz, Angel A, Zamora Tehozol, Erick, Vega Morales, David, Cervántes Rosete, Diana, Martín Nares, Eduardo, Rodriguez Reyna, Tatiana S, Rull Gabayet, Marina, Alpízar Rodríguez, Deshiré, Irazoque, Fedra, Jimenez, Xochitl, Geurts van Bon, Lenny, Zijlstra, Theo, Hoekstra, Monique, Al Adhoubi, Nasra, Salim, Babur, Giraldo, Enrique, Salinas, Ariel, Ugarte Gil, Manuel, Nowakowski, Jarosław, Conway, Richard, Flood, Rachael, McCarthy, Geraldine, Felea, Ioana, Filipescu, Ileana, Rednic, Simona, Groseanu, Laura, Tamas, Maria M, Mlynarikova, Vanda, Skamlova, Martina, Zlnay, Martin, Mičeková, Dagmar, Capova, Lubica, Macejova, Zelmira, Šteňová, Emőke, Raffayova, Helena, Belakova, Gabriela, Strakova, Eva, Senčarová, Marieta, Žlnayová, Soňa, Sabová, Anna, Spisakova, Daniela, Oetterová, Mária, Lukacova, Olga, Bakosova, Martina, Hocevar, Alojzija, de la Torre Rubio, Natalia, Alegre Sancho, Juan J, Corteguera Coro, Montserrat, Cobeta Garcia, Juan C, Torres Martin, Maria C, Campos, Jose, Gomez Puerta, Jose A, Yardimci, Gozd K, Akar, Servet, Icacan, Ozan C, ÇELİK, Selda, Vasylets, Viktoriia, Yeoh, Su-Ann, Vandevelde, Claire, Dunt, Sasha, Leeder, Jane, Macphie, Elizabeth, Salerno, Rosaria, Graver, Christine, Williams, Katie, O'Reilly, Sheila, Devine, Kirsty, Tyler, Jennifer, Warner, Elizabeth, Pilcher, James, Patel, Samir, Nikiphorou, Elena, Chadwick, Laura, Jones, Caroline M, Harrison, Beverley, Thornton, Lucy, O'Kane, Diana, Fusi, Lucia, Low, Audrey, Horton, Sarah, Jatwani, Shraddha, Baig, Sara, Bajwa, Hammad, Berglund, Vernon, Dahle, Angela, Dorman, Walter, Hargrove, Jody, Hilton, Maren, Lebedoff, Nicholas, Leonard, Susan, Morgan, Jennifer, Pfeifer, Emily, Skemp, Archibald, Wilson, Jeffrey, Wolff, Anne, Cepeda, Eduardo, Todd, Derrick, Hare, Denise, Calabrese, Cassandra, Adams, Christopher, Khosroshahi, Arezou, Kilian, Adam, White, Douglas, Winter, Melanie, Fields, Theodore, Siegel, Caroline, Daver, Nicole, Harvey, Melissa, Kramer, Neil, Lamore, Concetta, Hogarty, Suneya, Yeter, Karen, Siddique, Faizah, Ban, Byung, Tanner, Tamar, Ruderman, Eric, Davis, William, Quinet, Robert, Scopelitis, Evangeline, Toribio, Karen, Webb Detiege, Tameka, Zakem, Jerald, Abbass, Khurram, Kepecs, Gilbert, Miranda, Lilliam, Guma, Michael, Haikal, Ammar, Mody, Sushama, Mueller, Daric, Jayatilleke, Arundathi, Zell, JoAnn, Bays, Alison, Dao, Kathryn, Ezzati, Fatemeh, Parks, Deborah, Karp, David, Quiceno, Guillermo, Izadi, Zara, Gianfrancesco, Milena A, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Ja, Clairissa, Taylor, Tiffany, Shidara, Kie, Danila, Maria I, Wysham, Katherine D, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O, Ugarte-Gil, Manuel F, Ljung, Lotta, Scirè, Carlo A, Carrara, Greta, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Thomas, Thierry, Santos, Maria J, Bernardes, Miguel, Hasseli, Rebecca, Regierer, Anne, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Pons-Estel, Guillermo, Nieto, Romina E, Pisoni, Cecilia N, Tissera, Yohana S, Xavier, Ricardo, Lopes Marques, Claudia D, Pileggi, Gecilmara C S, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Gore-Massy, Monique, Wallace, Zachary S, and Yazdany, Jinoos

Published
2022
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10. Therapeutic strategies and outcomes in neuropsychiatric systemic lupus erythematosus: an international multicentre retrospective study.

Author

Bortoluzzi, Alessandra, Fanouriakis, Antonis, Silvagni, Ettore, Appenzeller, Simone, Carli, Linda, Carrara, Greta, Cauli, Alberto, Conti, Fabrizio, Costallat, Lilian Teresa Lavras, Marchi, Ginevra De, Doria, Andrea, Fredi, Micaela, Franceschini, Franco, Garaffoni, Carlo, Hanly, John G, Mosca, Marta, Murphy, Elana, Piga, Matteo, Quartuccio, Luca, and Scirè, Carlo Alberto

Subjects
SCALE analysis (Psychology), ADRENOCORTICAL hormones, NEUROLOGIC manifestations of general diseases, IMMUNOSUPPRESSIVE agents, RECEIVER operating characteristic curves, LOGISTIC regression analysis, SYSTEMIC lupus erythematosus, SEVERITY of illness index, TREATMENT effectiveness, RETROSPECTIVE studies, MULTIVARIATE analysis, DESCRIPTIVE statistics, LONGITUDINAL method, ODDS ratio, RESEARCH, CONFIDENCE intervals, ALGORITHMS
Abstract

Objectives The management of neuropsychiatric systemic lupus erythematosus (NPSLE) poses considerable challenges due to limited clinical trials. Therapeutic decisions are customized based on suspected pathogenic mechanisms and symptoms severity. This study aimed to investigate therapeutic strategies and disease outcome for patients with NPSLE experiencing their first neuropsychiatric (NP) manifestation. Methods This retrospective cohort study defined NP events according to the American College of Rheumatology case definition, categorizing them into three clusters: central/diffuse, central/focal and peripheral. Clinical judgment and a validated attribution algorithm were used for NP event attribution. Data included demographic variables, SLE disease activity index, cumulative organ damage, and NP manifestation treatments. The clinical outcome of all NP events was determined by a physician seven-point Likert scale. Predictors of clinical improvement/resolution were investigated in a multivariable logistic regression analysis. Results The analysis included 350 events. Immunosuppressants and corticosteroids were more frequently initiated/escalated for SLE-attributed central diffuse or focal NP manifestations. At 12 months of follow-up, 64% of patients showed a clinical improvement in NP manifestations. Focal central events and SLE-attributed manifestations correlated with higher rates of clinical improvement. Patients with NP manifestations attributed to SLE according to clinical judgment and treated with immunosuppressants had a significantly higher probability of achieving clinical response (OR 2.55, 95%CI 1.06–6.41, P  = 0.04). Age at diagnosis and focal central events emerged as additional response predictors. Conclusion NP manifestations attributed to SLE by clinical judgment and treated with immunosuppressants demonstrated improved 12-month outcomes. This underscores the importance of accurate attribution and timely diagnosis of NPSLE. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Definitions and reliability assessment of elementary ultrasound lesions in giant cell arteritis: a study from the OMERACT Large Vessel Vasculitis Ultrasound Working Group.

Author

Chrysidis, Stavros, Duftner, Christina, Dejaco, Christian, Schäfer, Valentin, Ramiro, Sofia, Carrara, Greta, Scirè, Carlo, Hocevar, Alojzija, Diamantopoulos, Andreas, Iagnocco, Annamaria, Mukhtyar, Chetan, Ponte, Cristina, Naredo, Esperanza, De Miguel, Eugenio, Bruyn, George, Warrington, Kenneth, Terslev, Lene, Milchert, Marcin, DAgostino, Maria, Koster, Mattew, Rastalsky, Naina, Hanova, Petra, Macchioni, Pierluigi, Kermani, Tanaz, Lorenzen, Tove, Døhn, Uffe, Fredberg, Ulrich, Hartung, Wolfgang, Dasgupta, Bhaskar, and Schmidt, Wolfgang

Abstract

ObjectivesTo define the elementary ultrasound (US) lesions in giant cell arteritis (GCA) and to evaluate the reliability of the assessment of US lesions according to these definitions in a web-based reliability exercise.MethodsPotential definitions of normal and abnormal US findings of temporal and extracranial large arteries were retrieved by a systematic literature review. As a subsequent step, a structured Delphi exercise was conducted involving an expert panel of the Outcome Measures in Rheumatology (OMERACT) US Large Vessel Vasculitis Group to agree definitions of normal US appearance and key elementary US lesions of vasculitis of temporal and extracranial large arteries. The reliability of these definitions on normal and abnormal blood vessels was tested on 150 still images and videos in a web-based reliability exercise.ResultsTwenty-four experts participated in both Delphi rounds. From originally 25 statements, nine definitions were obtained for normal appearance, vasculitis and arteriosclerosis of cranial and extracranial vessels. The halo and compression signs were the key US lesions in GCA. The reliability of the definitions for normal temporal and axillary arteries, the halo sign and the compression sign was excellent with inter-rater agreements of 91-99% and mean kappa values of 0.83-0.98 for both inter-rater and intra-rater reliabilities of all 25 experts.ConclusionsThe halo and the compression signs are regarded as the most important US abnormalities for GCA. The inter-rater and intra-rater agreement of the new OMERACT definitions for US lesions in GCA was excellent.

Published
2018

13. A Model Predicting the 6-month Disability of Patients with Traumatic Brain Injury to Assess the Quality of Care in Intensive Care Units: Results from the CREACTIVE Study

Author

Nattino, Giovanni, primary, Lameshow, Stanley, additional, Carrara, Greta, additional, Rossi, Carlotta, additional, Brissy, Obou, additional, Chieregato, Arturo, additional, Csomos, Akos, additional, Fleming, Joanne, additional, Giugni, Aimone, additional, Garadisek, Primoz, additional, Kaps, Rafael, additional, Kyprianou, Theodoros, additional, Lazar, Isaac, additional, Mikaszewska-Sokolewicz, Malgorzata, additional, Paci, Giulia, additional, Xirouchaki, Nektaria, additional, and Bertolini, Guido, additional

Published
2024
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15. Prognostic Implications of Declining Hemoglobin Content in Patients Hospitalized With Acute Coronary Syndromes

Author

Leonardi, Sergio, Gragnano, Felice, Carrara, Greta, Gargiulo, Giuseppe, Frigoli, Enrico, Vranckx, Pascal, Di Maio, Dario, Spedicato, Vanessa, Monda, Emanuele, Fimiani, Luigi, Fioretti, Vincenzo, Esposito, Fabrizio, Avvedimento, Marisa, Magliulo, Fabio, Leone, Attilio, Chianese, Salvatore, Franzese, Michele, Scalise, Martina, Schiavo, Alessandra, Mazzone, Paolo, Esposito, Giovanni, Andò, Giuseppe, Calabrò, Paolo, Windecker, Stephan, and Valgimigli, Marco

Published
2021
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16. Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospective Italian P-RHEUM.it study

Author

Andreoli, L, Gerardi, M, Gerosa, M, Rozza, D, Crisafulli, F, Erra, R, Lini, D, Trespidi, L, Padovan, M, Ruffilli, F, Serale, F, Cuomo, G, Raffeiner, B, Semeraro, P, Tani, C, Chimenti, M, Conigliaro, P, Hoxha, A, Nalli, C, Fredi, M, Lazzaroni, M, Filippini, M, Taglietti, M, Franceschini, F, Zatti, S, Loardi, C, Orabona, R, Ramazzotto, F, Zanardini, C, Fontana, G, Gozzoli, G, Barison, C, Bizioli, P, Caporali, R, Carrea, G, Ossola, M, Maranini, B, Silvagni, E, Govoni, M, Morano, D, Verteramo, R, Doria, A, Del Ross, T, Favaro, M, Calligaro, A, Tonello, M, Larosa, M, Zen, M, Zambon, A, Mosca, M, Zucchi, D, Elefante, E, Gori, S, Iannone, F, Anelli, M, Lavista, M, Abbruzzese, A, Fasano, C, D'Angelo, S, Cutro, M, Picerno, V, Carbone, T, Padula, A, Rovere-Querini, P, Canti, V, De Lorenzo, R, Cavallo, L, Ramoni, V, Montecucco, C, Codullo, V, Milanesi, A, Pazzola, G, Comitini, G, Marvisi, C, Salvarani, C, Epis, O, Benedetti, S, Di Raimondo, G, Gagliardi, C, Lomater, C, Crepaldi, G, Bellis, E, Bellisai, F, Garcia Gonzalez, E, Pata, A, Zerbinati, M, Urban, M, Mattioli, I, Iuliano, A, Sebastiani, G, Brucato, A, Bizzi, E, Cutolo, M, Santo, L, Tonetta, S, Landolfi, G, Carrara, G, Bortoluzzi, A, Scirè, C, Tincani, A, Andreoli, Laura, Gerardi, Maria Chiara, Gerosa, Maria, Rozza, Davide, Crisafulli, Francesca, Erra, Roberta, Lini, Daniele, Trespidi, Laura, Padovan, Melissa, Ruffilli, Francesca, Serale, Francesca, Cuomo, Giovanna, Raffeiner, Bernd, Semeraro, Paolo, Tani, Chiara, Chimenti, Maria Sole, Conigliaro, Paola, Hoxha, Ariela, Nalli, Cecilia, Fredi, Micaela, Lazzaroni, Maria Grazia, Filippini, Matteo, Taglietti, Marco, Franceschini, Franco, Zatti, Sonia, Loardi, Chiara, Orabona, Rossana, Ramazzotto, Francesca, Zanardini, Cristina, Fontana, Giulia, Gozzoli, Giorgia, Barison, Claudia, Bizioli, Paola, Caporali, Roberto Felice, Carrea, Giulia, Ossola, Manuela Wally, Maranini, Beatrice, Silvagni, Ettore, Govoni, Marcello, Morano, Danila, Verteramo, Rosita, Doria, Andrea, Del Ross, Teresa, Favaro, Maria, Calligaro, Antonia, Tonello, Marta, Larosa, Maddalena, Zen, Margherita, Zambon, Alessandra, Mosca, Marta, Zucchi, Dina, Elefante, Elena, Gori, Sabrina, Iannone, Florenzo, Anelli, Maria Grazia, Lavista, Marlea, Abbruzzese, Anna, Fasano, Carlo Giuseppe, D'Angelo, Salvatore, Cutro, Maria Stefania, Picerno, Valentina, Carbone, Teresa, Padula, Angela Anna, Rovere-Querini, Patrizia, Canti, Valentina, De Lorenzo, Rebecca, Cavallo, Ludovica, Ramoni, Véronique, Montecucco, Carlomaurizio, Codullo, Veronica, Milanesi, Alessandra, Pazzola, Giulia, Comitini, Giuseppina, Marvisi, Chiara, Salvarani, Carlo, Epis, Oscar Massimiliano, Benedetti, Sara, Di Raimondo, Giuseppina, Gagliardi, Clizia, Lomater, Claudia, Crepaldi, Gloria, Bellis, Elisa, Bellisai, Francesca, Garcia Gonzalez, Estrella, Pata, Anna Paola, Zerbinati, Martina, Urban, Maria Letizia, Mattioli, Irene, Iuliano, Annamaria, Sebastiani, Giandomenico, Brucato, Antonio Luca, Bizzi, Emanuele, Cutolo, Maurizio, Santo, Leonardo, Tonetta, Sara, Landolfi, Gianpiero, Carrara, Greta, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, Tincani, Angela, Andreoli, L, Gerardi, M, Gerosa, M, Rozza, D, Crisafulli, F, Erra, R, Lini, D, Trespidi, L, Padovan, M, Ruffilli, F, Serale, F, Cuomo, G, Raffeiner, B, Semeraro, P, Tani, C, Chimenti, M, Conigliaro, P, Hoxha, A, Nalli, C, Fredi, M, Lazzaroni, M, Filippini, M, Taglietti, M, Franceschini, F, Zatti, S, Loardi, C, Orabona, R, Ramazzotto, F, Zanardini, C, Fontana, G, Gozzoli, G, Barison, C, Bizioli, P, Caporali, R, Carrea, G, Ossola, M, Maranini, B, Silvagni, E, Govoni, M, Morano, D, Verteramo, R, Doria, A, Del Ross, T, Favaro, M, Calligaro, A, Tonello, M, Larosa, M, Zen, M, Zambon, A, Mosca, M, Zucchi, D, Elefante, E, Gori, S, Iannone, F, Anelli, M, Lavista, M, Abbruzzese, A, Fasano, C, D'Angelo, S, Cutro, M, Picerno, V, Carbone, T, Padula, A, Rovere-Querini, P, Canti, V, De Lorenzo, R, Cavallo, L, Ramoni, V, Montecucco, C, Codullo, V, Milanesi, A, Pazzola, G, Comitini, G, Marvisi, C, Salvarani, C, Epis, O, Benedetti, S, Di Raimondo, G, Gagliardi, C, Lomater, C, Crepaldi, G, Bellis, E, Bellisai, F, Garcia Gonzalez, E, Pata, A, Zerbinati, M, Urban, M, Mattioli, I, Iuliano, A, Sebastiani, G, Brucato, A, Bizzi, E, Cutolo, M, Santo, L, Tonetta, S, Landolfi, G, Carrara, G, Bortoluzzi, A, Scirè, C, Tincani, A, Andreoli, Laura, Gerardi, Maria Chiara, Gerosa, Maria, Rozza, Davide, Crisafulli, Francesca, Erra, Roberta, Lini, Daniele, Trespidi, Laura, Padovan, Melissa, Ruffilli, Francesca, Serale, Francesca, Cuomo, Giovanna, Raffeiner, Bernd, Semeraro, Paolo, Tani, Chiara, Chimenti, Maria Sole, Conigliaro, Paola, Hoxha, Ariela, Nalli, Cecilia, Fredi, Micaela, Lazzaroni, Maria Grazia, Filippini, Matteo, Taglietti, Marco, Franceschini, Franco, Zatti, Sonia, Loardi, Chiara, Orabona, Rossana, Ramazzotto, Francesca, Zanardini, Cristina, Fontana, Giulia, Gozzoli, Giorgia, Barison, Claudia, Bizioli, Paola, Caporali, Roberto Felice, Carrea, Giulia, Ossola, Manuela Wally, Maranini, Beatrice, Silvagni, Ettore, Govoni, Marcello, Morano, Danila, Verteramo, Rosita, Doria, Andrea, Del Ross, Teresa, Favaro, Maria, Calligaro, Antonia, Tonello, Marta, Larosa, Maddalena, Zen, Margherita, Zambon, Alessandra, Mosca, Marta, Zucchi, Dina, Elefante, Elena, Gori, Sabrina, Iannone, Florenzo, Anelli, Maria Grazia, Lavista, Marlea, Abbruzzese, Anna, Fasano, Carlo Giuseppe, D'Angelo, Salvatore, Cutro, Maria Stefania, Picerno, Valentina, Carbone, Teresa, Padula, Angela Anna, Rovere-Querini, Patrizia, Canti, Valentina, De Lorenzo, Rebecca, Cavallo, Ludovica, Ramoni, Véronique, Montecucco, Carlomaurizio, Codullo, Veronica, Milanesi, Alessandra, Pazzola, Giulia, Comitini, Giuseppina, Marvisi, Chiara, Salvarani, Carlo, Epis, Oscar Massimiliano, Benedetti, Sara, Di Raimondo, Giuseppina, Gagliardi, Clizia, Lomater, Claudia, Crepaldi, Gloria, Bellis, Elisa, Bellisai, Francesca, Garcia Gonzalez, Estrella, Pata, Anna Paola, Zerbinati, Martina, Urban, Maria Letizia, Mattioli, Irene, Iuliano, Annamaria, Sebastiani, Giandomenico, Brucato, Antonio Luca, Bizzi, Emanuele, Cutolo, Maurizio, Santo, Leonardo, Tonetta, Sara, Landolfi, Gianpiero, Carrara, Greta, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, and Tincani, Angela

Abstract

Objectives To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it. Methods Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29 Rheumatology Centres for 5 years (2018-2023). Maternal and infant information were collected in a web-based database. Results We analysed 866 pregnancies in 851 patients (systemic lupus erythematosus was the most represented disease, 19.6%). Maternal disease flares were observed in 135 (15.6%) pregnancies. 53 (6.1%) pregnancies were induced by assisted reproduction techniques, 61 (7%) ended in miscarriage and 11 (1.3%) underwent elective termination. Obstetrical complications occurred in 261 (30.1%) pregnancies, including 2.3% pre-eclampsia. Two cases of congenital heart block were observed out of 157 pregnancies (1.3%) with anti-Ro/SSA. Regarding treatments, 244 (28.2%) pregnancies were treated with glucocorticoids, 388 (44.8%) with hydroxychloroquine, 85 (9.8%) with conventional synthetic disease-modifying anti-rheumatic drugs and 122 (14.1%) with biological disease-modifying anti-rheumatic drugs. Live births were 794 (91.7%), mostly at term (84.9%); four perinatal deaths (0.5%) occurred. Among 790 newborns, 31 (3.9%) were small-for-gestational-age and 169 (21.4%) had perinatal complications. Exclusive maternal breast feeding was received by 404 (46.7%) neonates. The Edinburgh Postnatal Depression Scale was compiled by 414 women (52.4%); 89 (21.5%) scored positive for emotional distress. Conclusions Multiple factors including preconception counselling and treat-to-target with pregnancy-compatible medications may have contributed to mitigate disease-related risk factors, yielding limited disease flares, good pregnancy outcomes and frequency of complications which were similar to the Italian general obstetric population. Disease-specific issues need to be further addressed to plan preventative measures.

Published
2024

17. A multiparametric risk table for loss of clinical remission status in patients with rheumatoid arthritis: A starter study post-hoc analysis

Author

Perniola, Simone, Alivernini, Stefano, Gremese, Elisa, Landolfi, Gianpiero, Carrara, Greta, Iagnocco, Annamaria, Scirè, Carlo alberto, alivernini, Stefano (ORCID:0000-0002-7383-4212), gremese, Elisa (ORCID:0000-0002-2248-1058), Perniola, Simone, Alivernini, Stefano, Gremese, Elisa, Landolfi, Gianpiero, Carrara, Greta, Iagnocco, Annamaria, Scirè, Carlo alberto, alivernini, Stefano (ORCID:0000-0002-7383-4212), and gremese, Elisa (ORCID:0000-0002-2248-1058)

Abstract

Objective: This post-hoc analysis was carried out on data acquired in the longitudinal Sonographic Tenosynovitis/arthritis Assessment in Rheumatoid Arthritis Patients in Remission (STARTER) study. Its primary aim was to determine the predictive clinical and MSUS features factors for disease flare in RA patients in clinical remission, whilst its secondary aim was to evaluate the probability of disease flare based on clinical and MSUS features. Methods: The analysis included a total of 389 RA patients in DAS28-defined remission. All patients underwent a MSUS examination according to OMERACT guidelines. Logistic regression and results presented as OR and 95%CI were used for the evaluation of the association between selected variables and disease flare. Significant clinical and MSUS features were incorporated into a risk table to predict disease flare within 12 months in RA remission patients. Results: Within 12 months, 137(35%) RA patients experienced a disease flare. RA patients who experienced a flare disease differed from persistent remission for ACPA positivity (75.9%vs62.3%; p= 0.007), percentage of sustained clinical remission at baseline (44.1%vs68.5%; p= 0.001) and synovium PD signal presence (58.4%vs33.3%; p< 0.001). Based on these results, the three features were considered in a predictive model of disease flare with adjOR 3.064(95%CI 1.728-5.432). Finally, a risk table was constructed including the three significant predictive factors of disease flare within 12 months from the enrolment. Conclusion: An adaptive flare prediction model tool, based on data available in outpatient setting, were developed as a multiparametric risk table. If confirmed by the external validation, this tool might support the definition of therapeutic strategies in RA patients in DAS28-defined remission status.

Published
2024

18. Diagnosis of calcium pyrophosphate crystal deposition disease by ultrasonography: how many and which sites should be scanned?

Author

Cipolletta, Edoardo, Moscioni, Erica, Sirotti, Silvia, Battista, Jacopo Di, Abhishek, Abhishek, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Scirè, Carlo Alberto, Grassi, Walter, Filippou, Georgios, and Filippucci, Emilio

Subjects
CROSS-sectional method, MEDICAL protocols, WRIST, METACARPOPHALANGEAL joint, ANKLE, ACADEMIC medical centers, RECEIVER operating characteristic curves, T-test (Statistics), BODY mass index, SYNOVIAL fluid, SHOULDER, RESEARCH evaluation, PILOT projects, LOGISTIC regression analysis, DESCRIPTIVE statistics, MANN Whitney U Test, CHI-squared test, DISEASE prevalence, JOINTS (Anatomy), LONGITUDINAL method, HIP joint, ELBOW, STATISTICS, CHONDROCALCINOSIS, KNEE, CONFIDENCE intervals, DATA analysis software, SENSITIVITY & specificity (Statistics), INTER-observer reliability
Abstract

Objective To develop the optimal US scanning protocol for the diagnosis of calcium pyrophosphate crystal deposition (CPPD) disease. Methods In this cross-sectional study, consecutive patients with a crystal-proven diagnosis of CPPD disease, and age-, sex-matched disease controls with a negative synovial fluid analysis were prospectively enrolled in two Italian Institutions. Four rheumatologists, blinded to patients' clinical details, performed US examinations using a standardized scanning protocol including 20 joints (shoulders, elbows, wrists, metacarpophalangeal joints from second to fifth fingers, hips, knees, ankles). CPPD was identified as presence/absence, according to the OMERACT definitions. Reduced US scanning protocols were developed by selecting the most informative joints to be imaged by US using the LASSO technique. Patients were randomly divided into training and validation sets. Their diagnostic accuracy was tested comparing the area under the receiver operating characteristic curves. Results The number of participants enrolled was 204: 102 with CPPD disease and 102 disease controls [age, mean (s. d.): 71.3 (12.0) vs 71.1 (13.5) years; female: 62.8% vs 57.8%]. The median number of joints with US evidence of CPPD was 5 [interquartile range (IQR): 4–7] and 0 (IQR: 0–1) in patients with CPPD disease and controls, respectively (P  < 0.01). The detection of CPPD in ≥2 joints using a reduced scanning protocol (bilateral assessment of knees, wrists and hips) showed a sensitivity of 96.7% (95% CI: 82.8, 99.9) and a specificity of 100 (95% CI: 88.8, 100.0) for the diagnosis of CPPD disease and had good feasibility [mean (s. d.): 12.5 (5.3) min]. Conclusion Bilateral US assessment of knees, wrists and hips had excellent accuracy and good feasibility for the diagnosis of CPPD disease. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Hospitals with and without neurosurgery: a comparative study evaluating the outcome of patients with traumatic brain injury

Author

Giugni, Aimone, Gamberini, Lorenzo, Carrara, Greta, Antiga, Luca, Brissy, Obou, Buldini, Virginia, Calamai, Italo, Csomos, Akos, De Luca, Alessandra, Ferri, Enrico, Fleming, Joanne M., Gradisek, Primoz, Kaps, Rafael, Kyprianou, Theodoros, Lagomarsino, Silvia, Lazar, Isaac, Martino, Costanza, Mikaszewska-Sokolewicz, Malgorzata, Montis, Andrea, Nardai, Gabor, Nattino, Giovanni, Nattino, Giuseppe, Paci, Giulia, Portolani, Laila, Xirouchaki, Nektaria, Chieregato, Arturo, and Bertolini, Guido

Published
2021
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21. Post-Procedural Bivalirudin Infusion at Full or Low Regimen in Patients With Acute Coronary Syndrome

Author

Gargiulo, Giuseppe, Carrara, Greta, Frigoli, Enrico, Leonardi, Sergio, Vranckx, Pascal, Campo, Gianluca, Varbella, Ferdinando, Calabrò, Paolo, Zaro, Tiziana, Bartolini, Davide, Briguori, Carlo, Andò, Giuseppe, Ferrario, Maurizio, Limbruno, Ugo, Colangelo, Salvatore, Sganzerla, Paolo, Russo, Filippo, Nazzaro, Marco Stefano, Esposito, Giovanni, Ferrante, Giuseppe, Santarelli, Andrea, Sardella, Gennaro, Windecker, Stephan, and Valgimigli, Marco

Published
2019
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22. Diagnosis of calcium pyrophosphate crystal deposition disease by ultrasonography: how many and which sites should be scanned?

Author

Cipolletta, Edoardo, primary, Moscioni, Erica, additional, Sirotti, Silvia, additional, Di Battista, Jacopo, additional, Abhishek, Abhishek, additional, Rozza, Davide, additional, Zanetti, Anna, additional, Carrara, Greta, additional, Scirè, Carlo Alberto, additional, Grassi, Walter, additional, Filippou, Georgios, additional, and Filippucci, Emilio, additional

Published
2023
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23. COVID-19 prognosis in systemic lupus erythematosus compared with rheumatoid arthritis and spondyloarthritis: results from the CONTROL-19 Study by the Italian Society for Rheumatology

Author

Scirocco, Chiara, primary, Ferrigno, Sara, additional, Andreoli, Laura, additional, Fredi, Micaela, additional, Lomater, Claudia, additional, Moroni, Luca, additional, Mosca, Marta, additional, Raffeiner, Bernd, additional, Carrara, Greta, additional, Landolfi, Gianpiero, additional, Rozza, Davide, additional, Zanetti, Anna, additional, Scirè, Carlo Alberto, additional, and Sebastiani, Gian Domenico, additional

Published
2023
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25. Bivalirudin or Heparin in Patients Undergoing Invasive Management of Acute Coronary Syndromes

Author

Gargiulo, Giuseppe, Carrara, Greta, Frigoli, Enrico, Vranckx, Pascal, Leonardi, Sergio, Ciociano, Nestor, Campo, Gianluca, Varbella, Ferdinando, Calabrò, Paolo, Garducci, Stefano, Iannone, Alessandro, Briguori, Carlo, Andò, Giuseppe, Crimi, Gabriele, Limbruno, Ugo, Garbo, Roberto, Sganzerla, Paolo, Russo, Filippo, Lupi, Alessandro, Cortese, Bernardo, Ausiello, Arturo, Ierna, Salvatore, Esposito, Giovanni, Zavalloni, Dennis, Santarelli, Andrea, Sardella, Gennaro, Tresoldi, Simone, de Cesare, Nicoletta, Sciahbasi, Alessandro, Zingarelli, Antonio, Tosi, Paolo, van ’t Hof, Arnoud, Omerovic, Elmir, Brugaletta, Salvatore, Windecker, Stephan, and Valgimigli, Marco

Published
2018
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27. Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People with Rheumatic Diseases

Author

Yazdany, Jinoos, primary, Ware, Anna, additional, Wallace, Zachary S, additional, Bhana, Suleman, additional, Grainger, Rebecca, additional, Hachulla, Eric, additional, Richez, Christophe, additional, Cacoub, Patrice, additional, Hausmann, Jonathan S, additional, Liew, Jean W, additional, Sirotich, Emily, additional, Jacobsohn, Lindsay, additional, Strangfeld, Anja, additional, Mateus, Elsa F, additional, Hyrich, Kimme L, additional, Gossec, Laure, additional, Carmona, Loreto, additional, Lawson‐Tovey, Saskia, additional, Kearsley‐Fleet, Lianne, additional, Schaefer, Martin, additional, Ribeiro, Sandra Lucia Euzebio, additional, Al‐Emadi, Samar, additional, Hasseli, Rebecca, additional, Müller‐Ladner, Ulf, additional, Specker, Christof, additional, Schulze‐Koops, Hendrik, additional, Bernardes, Miguel, additional, Machado Fraga, Vanessa, additional, Rodrigues, Ana Maria, additional, Sparks, Jeffrey A., additional, Ljung, Lotta, additional, Di Giuseppe, Daniela, additional, Tidblad, Liselotte, additional, Wise, Leanna, additional, Duarte‐García, Alí, additional, Ugarte‐Gil, Manuel F., additional, Colunga‐Pedraza, Iris Jazmín, additional, Martínez‐Martínez, Marco Ulises, additional, Alpizar‐Rodriguez, Deshire, additional, Xavier, Ricardo Machado, additional, Isnardi, Carolina A, additional, Pera, Mariana, additional, Pons‐Estel, Guillermo, additional, Izadi, Zara, additional, Gianfrancesco, Milena A, additional, Carrara, Greta, additional, Scirè, Carlo Alberto, additional, Zanetti, Anna, additional, and Machado, Pedro M, additional

Published
2023
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28. Systemic sclerosis sine scleroderma: clinical and serological features and relationship with other cutaneous subsets in a large series of patients from the national registry ‘SPRING’ of the Italian Society for Rheumatology

Author

De Angelis, Rossella, primary, Ferri, Clodoveo, additional, Giuggioli, Dilia, additional, Bajocchi, Gianluigi, additional, Dagna, Lorenzo, additional, Bellando-Randone, Silvia, additional, Zanframundo, Giovanni, additional, Foti, Rosario, additional, Cacciapaglia, Fabio, additional, Cuomo, Giovanna, additional, Ariani, Alarico, additional, Rosato, Edoardo, additional, Lepri, Gemma, additional, Girelli, Francesco, additional, Riccieri, Valeria, additional, Zanatta, Elisabetta, additional, Bosello, Silvia Laura, additional, Cavazzana, Ilaria, additional, Ingegnoli, Francesca, additional, De Santis, Maria, additional, Murdaca, Giuseppe, additional, Abignano, Giuseppina, additional, Romeo, Nicoletta, additional, Della Rossa, Alessandra, additional, Caminiti, Maurizio, additional, Iuliano, Anna Maria, additional, Ciano, Giovanni, additional, Beretta, Lorenzo, additional, Bagnato, Gianluca, additional, Lubrano, Ennio, additional, De Andres, Ilenia, additional, Giollo, Alessandro, additional, Saracco, Marta, additional, Agnes, Cecilia, additional, Cipolletta, Edoardo, additional, Lumetti, Federica, additional, Spinella, Amelia, additional, Magnani, Luca, additional, Campochiaro, Corrado, additional, De Luca, Giacomo, additional, Codullo, Veronica, additional, Visalli, Elisa, additional, Di Vico, Claudio, additional, Gigante, Antonietta, additional, Pellagrino, Greta, additional, Pigatto, Erika, additional, Lazzaroni, Maria-Grazia, additional, Franceschini, Franco, additional, Generali, Elena, additional, Mennillo, Gianna, additional, Barsotti, Simone, additional, Mariano, Giuseppa Pagano, additional, Furini, Federica, additional, Vultaggio, Licia, additional, Parisi, Simone, additional, Peroni, Clara Lisa, additional, Rozza, Davide, additional, Zanetti, Anna, additional, Carrara, Greta, additional, Landolfi, Gianpiero, additional, Scirè, Carlo Alberto, additional, Bianchi, Gerolamo, additional, Fusaro, Enrico, additional, Sebastiani, Gian Domenico, additional, Govoni, Marcello, additional, D'Angelo, Salvatore, additional, Cozzi, Franco, additional, Guiducci, Serena, additional, Doria, Andrea, additional, Salvarani, Carlo, additional, Iannone, Florenzo, additional, and Matucci-Cerinic, Marco, additional

Published
2023
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29. Effect of a quality improvement program on compliance to the sepsis bundle in non-ICU patients: a multicenter prospective before and after cohort study

Author

Monti, G, Rezoagli, E, Calini, A, Nova, A, Marchesi, S, Nattino, G, Carrara, G, Morra, S, Cortellaro, F, Savioli, M, Capra Marzani, F, Tresoldi, M, Villa, P, Greco, S, Bonfanti, P, Spitoni, M, Vesconi, S, Caironi, P, Fumagalli, R, Monti, Gianpaola, Rezoagli, Emanuele, Calini, Angelo, Nova, Alice, Marchesi, Silvia, Nattino, Giovanni, Carrara, Greta, Morra, Sergio, Cortellaro, Francesca, Savioli, Monica, Capra Marzani, Federico, Tresoldi, Moreno, Villa, Paolo, Greco, Stefano, Bonfanti, Paolo, Spitoni, Maria Grazia, Vesconi, Sergio, Caironi, Pietro, Fumagalli, Roberto, Monti, G, Rezoagli, E, Calini, A, Nova, A, Marchesi, S, Nattino, G, Carrara, G, Morra, S, Cortellaro, F, Savioli, M, Capra Marzani, F, Tresoldi, M, Villa, P, Greco, S, Bonfanti, P, Spitoni, M, Vesconi, S, Caironi, P, Fumagalli, R, Monti, Gianpaola, Rezoagli, Emanuele, Calini, Angelo, Nova, Alice, Marchesi, Silvia, Nattino, Giovanni, Carrara, Greta, Morra, Sergio, Cortellaro, Francesca, Savioli, Monica, Capra Marzani, Federico, Tresoldi, Moreno, Villa, Paolo, Greco, Stefano, Bonfanti, Paolo, Spitoni, Maria Grazia, Vesconi, Sergio, Caironi, Pietro, and Fumagalli, Roberto

Abstract

Objective: Sepsis and septic shock are major challenges and economic burdens to healthcare, impacting millions of people globally and representing significant causes of mortality. Recently, a large number of quality improvement programs focused on sepsis resuscitation bundles have been instituted worldwide. These educational initiatives have been shown to be associated with improvements in clinical outcomes. We aimed to evaluate the impact of a multi-faceted quality implementing program (QIP) on the compliance of a “simplified 1-h bundle” (Sepsis 6) and hospital mortality of severe sepsis and septic shock patients out of the intensive care unit (ICU). Methods: Emergency departments (EDs) and medical wards (MWs) of 12 academic and non-academic hospitals in the Lombardy region (Northern Italy) were involved in a multi-faceted QIP, which included educational and organizational interventions. Patients with a clinical diagnosis of severe sepsis or septic shock according to the Sepsis-2 criteria were enrolled in two different periods: from May 2011 to November 2011 (before-QIP cohort) and from August 2012 to June 2013 (after-QIP cohort). Measurements and main results: The effect of QIP on bundle compliance and hospital mortality was evaluated in a before–after analysis. We enrolled 467 patients in the before-QIP group and 656 in the after-QIP group. At the time of enrollment, septic shock was diagnosed in 50% of patients, similarly between the two periods. In the after-QIP group, we observed increased compliance to the “simplified rapid (1 h) intervention bundle” (the Sepsis 6 bundle – S6) at three time-points evaluated (1 h, 13.7 to 18.7%, p = 0.018, 3 h, 37.1 to 48.0%, p = 0.013, overall study period, 46.2 to 57.9%, p < 0.001). We then analyzed compliance with S6 and hospital mortality in the before- and after-QIP periods, stratifying the two patients’ cohorts by admission characteristics. Adherence to the S6 bundle was increased in patients with severe sepsis in the

Published
2023

30. Reliability assessment of ultrasound muscle echogenicity in patients with rheumatic diseases: Results of a multicenter international web-based study

Author

Di Matteo, Andrea, primary, Moscioni, Erica, additional, Lommano, Maria Giovanna, additional, Cipolletta, Edoardo, additional, Smerilli, Gianluca, additional, Farah, Sonia, additional, Airoldi, Carla, additional, Aydin, Sibel Zehra, additional, Becciolini, Andrea, additional, Bonfiglioli, Karina, additional, Carotti, Marina, additional, Carrara, Greta, additional, Cazenave, Tomas, additional, Corradini, Davide, additional, Cosatti, Micaela Ana, additional, de Agustin, Juan Josè, additional, Destro Castaniti, Giulia Maria, additional, Di Carlo, Marco, additional, Di Donato, Eleonora, additional, Di Geso, Luca, additional, Elliott, Ashley, additional, Fodor, Daniela, additional, Francioso, Francesca, additional, Gabba, Alessandra, additional, Hernández-Díaz, Cristina, additional, Horvath, Rudolf, additional, Hurnakova, Jana, additional, Jesus, Diogo, additional, Marin, Josefina, additional, Martire, Maria Victoria, additional, Mashadi Mirza, Riccardo, additional, Massarotti, Marco, additional, Musca, Alice Andreea, additional, Nair, Jagdish, additional, Okano, Tadashi, additional, Papalopoulos, Ioannis, additional, Rosa, Javier, additional, Rosemffet, Marcos, additional, Rovisco, João, additional, Rozza, Davide, additional, Salaffi, Fausto, additional, Scioscia, Crescenzio, additional, Scirè, Carlo Alberto, additional, Tamas, Maria-Magdalena, additional, Tanimura, Shun, additional, Ventura-Rios, Lucio, additional, Villota-Eraso, Catalina, additional, Villota, Orlando, additional, Voulgari, Paraskevi V., additional, Vreju, Florentin Ananu, additional, Vukatana, Gentiana, additional, Hereter, Johana Zacariaz, additional, Zanetti, Anna, additional, Grassi, Walter, additional, and Filippucci, Emilio, additional

Published
2023
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31. Intensive care medicine in 2050: statistical tools for development of prognostic models (why clinicians should not be ignored)

Author

Poole, Daniele, Carrara, Greta, and Bertolini, Guido

Subjects
Statistical models -- Usage, Prognosis -- Methods, Critical care medicine -- Methods -- Forecasts and trends, Market trend/market analysis, Health care industry
Abstract

Author(s): Daniele Poole [sup.1] , Greta Carrara [sup.2] , Guido Bertolini [sup.2] Author Affiliations: (1) 0000 0004 1756 7871, grid.410345.7, Anesthesia and Intensive Care Operative Unit, S. Martino Hospital, , [...]

Published
2017
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32. Cost‐Effectiveness of the Early Arthritis Clinic Organizational Model

Author

Zanetti, Anna, primary, Sakellariou, Garifallia, additional, Zambon, Antonella, additional, Carrara, Greta, additional, Argnani, Lisa, additional, Mantovani, Lorenzo G., additional, Cortesi, Paolo A., additional, Bugatti, Serena, additional, Montecucco, Carlomaurizio, additional, and Scirè, Carlo A., additional

Published
2022
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33. Glucocorticoid tapering and associated outcome in patients with newly diagnosed systemic lupus erythematosus: the real-world GULP prospective observational study

Author

Floris, Alberto, primary, Chessa, Elisabetta, additional, Sebastiani, Gian Domenico, additional, Prevete, Immacolata, additional, Iannone, Florenzo, additional, Coladonato, Laura, additional, Govoni, Marcello, additional, Bortoluzzi, Alessandra, additional, Mosca, Marta, additional, Tani, Chiara, additional, Doria, Andrea, additional, Iaccarino, Luca, additional, Franceschini, Franco, additional, Fredi, Micaela, additional, Conti, Fabrizio, additional, Spinelli, Francesca Romana, additional, Bellisai, Francesca, additional, D'Alessandro, Roberto, additional, Zanetti, Anna, additional, Carrara, Greta, additional, Scirè, Carlo Alberto, additional, Cauli, Alberto, additional, and Piga, Matteo, additional

Published
2022
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34. The challenge of the definition of early symptomatic knee osteoarthritis: a proposal of criteria and red flags from an international initiative promoted by the Italian Society for Rheumatology

Author

Migliore, Alberto, Scirè, Carlo Alberto, Carmona, Loreto, Beaumont, Gabriel Herrero, Bizzi, Emanuele, Branco, Jaime, Carrara, Greta, Chevalier, Xavier, Collaku, Ledio, Aslanidis, Spiros, Denisov, Lev, Di Matteo, Luigi, Bianchi, Gerolamo, Diracoglu, Demirhan, Frediani, Bruno, Maheu, Emmanuel, Martusevich, Natalia, Bagnato, Gian Filippo, Scarpellini, Magda, Minisola, Giovanni, Akkoc, Nurullah, Ramonda, Roberta, Barskova, Tatiana, Babic-Naglic, Durda, Muelas, Jose Vicente Moreno, Ionescu, Ruxandra, Rashkov, Rasho, Damjanov, Nemanja, and Cerinic, Marco Matucci

Published
2017
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35. Development of a Prediction Model for COVID-19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases

Author

Izadi, Zara, Gianfrancesco, Milena A., Aguirre, Alfredo, Strangfeld, Anja, Mateus, Elsa F., Hyrich, Kimme L., Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Seet, Andrea M., Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Al-Emadi, Samar, Sparks, Jeffrey A., Hsu, Tiffany Y.T., Patel, Naomi J., Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O., Ugarte-Gil, Manuel F., Ribeiro, Sandra Lúcia Euzébio, de Oliveira Marinho, Adriana, de Azevedo Valadares, Lilian David, Giuseppe, Daniela Di, Hasseli, Rebecca, Richter, Jutta G., Pfeil, Alexander, Schmeiser, Tim, Isnardi, Carolina A., Reyes Torres, Alvaro A., Alle, Gelsomina, Saurit, Verónica, Zanetti, Anna, Carrara, Greta, Labreuche, Julien, Barnetche, Thomas, Herasse, Muriel, Plassart, Samira, Santos, Maria José, Rodrigues, Ana Maria, Robinson, Philip C., Machado, Pedro M., Sirotich, Emily, Liew, Jean W., Hausmann, Jonathan S., NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)

Subjects
Rheumatology
Abstract

Funding Information: We acknowledge financial support from the ACR and EULAR. The ACR and EULAR were not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: © 2022 The Authors. ACR Open Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. Objective: Some patients with rheumatic diseases might be at higher risk for coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS). We aimed to develop a prediction model for COVID-19 ARDS in this population and to create a simple risk score calculator for use in clinical settings. Methods: Data were derived from the COVID-19 Global Rheumatology Alliance Registry from March 24, 2020, to May 12, 2021. Seven machine learning classifiers were trained on ARDS outcomes using 83 variables obtained at COVID-19 diagnosis. Predictive performance was assessed in a US test set and was validated in patients from four countries with independent registries using area under the curve (AUC), accuracy, sensitivity, and specificity. A simple risk score calculator was developed using a regression model incorporating the most influential predictors from the best performing classifier. Results: The study included 8633 patients from 74 countries, of whom 523 (6%) had ARDS. Gradient boosting had the highest mean AUC (0.78; 95% confidence interval [CI]: 0.67-0.88) and was considered the top performing classifier. Ten predictors were identified as key risk factors and were included in a regression model. The regression model that predicted ARDS with 71% (95% CI: 61%-83%) sensitivity in the test set, and with sensitivities ranging from 61% to 80% in countries with independent registries, was used to develop the risk score calculator. Conclusion: We were able to predict ARDS with good sensitivity using information readily available at COVID-19 diagnosis. The proposed risk score calculator has the potential to guide risk stratification for treatments, such as monoclonal antibodies, that have potential to reduce COVID-19 disease progression. publishersversion published

Published
2022

36. Sex-related Differences in Systemic Sclerosis: A Multicenter Cross-sectional Study From the National Registry of the Italian Society for Rheumatology

Author

De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia Laura, Cavazzana, Ilaria, Ingegnoli, Francesca, Santis, Maria De, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Dall'Ara, Francesca, Lazzaroni, Maria Grazia, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Mariano, Giuseppa Pagano, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Risa, Anna Maria, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, Matucci-Cerinic, Marco, Ferri, Clodoveo, Bosello, Silvia (ORCID:0000-0002-4837-447X), De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia Laura, Cavazzana, Ilaria, Ingegnoli, Francesca, Santis, Maria De, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Dall'Ara, Francesca, Lazzaroni, Maria Grazia, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Mariano, Giuseppa Pagano, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Risa, Anna Maria, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, Matucci-Cerinic, Marco, Ferri, Clodoveo, and Bosello, Silvia (ORCID:0000-0002-4837-447X)

Abstract

Objective. There is still a great deal to learn about the influence of sex in systemic sclerosis (SSc). In this respect, national registries provide large and homogeneous patient cohorts for analytical studies. We therefore investigated a wide-ranging and well-characterized SSc series with the aim of identifying sex differences in disease expression, with a special focus on demographic, clinical, and serological characteristics.Methods. A multicenter SSc cohort of 2281 patients, including 247 men, was recruited in the Italian Systemic sclerosis PRogression INvestiGation (SPRING) registry. Demographic data, disease manifestations, serological profile, and internal organ involvement were compared.Results. The overall female/male ratio was 8.2:1. Female/male ratios for limited cutaneous SSc, diffuse cutaneous SSc, and SSc sine scleroderma subsets were 8.7:1, 4.9:1, and 10.7:1, respectively. A shorter time from onset of Raynaud phenomenon to SSc diagnosis, an increased prevalence of the diffuse cutaneous subset, renal crisis, and digital ulcers were found in males, whereas a significantly higher percentage of sicca syndrome, serum antinuclear antibodies, antiextractable nuclear antigens, anti-La/SSB, and anticentromere protein B was detected in the female group. Males exhibited lower left ventricular ejection fraction, as well as higher prevalence of conduction blocks, arrhythmias, ground glass, and honeycombing. Moreover, forced vital capacity and total lung capacity were medially lower in men than in women. Finally, males were more frequently treated with immunosuppressive drugs.Conclusion. Our study further supports the presence of several sex-related differences in patients with SSc. These differences were pronounced in the severity of cutaneous, peripheral vascular, and cardiopulmonary involvement for male patients, whereas an increased prevalence of sicca syndrome and a specific autoantibody profile characterized the female sex.

Published
2022

37. Relationship between the prevalence of subclinical tenosynovitis and treatment in patients with RA in clinical remission: STARTER study.

Author

Parisi, Simone, Zanetti, Anna, Carrara, Greta, Scirè, Carlo Alberto, Iagnocco, Annamaria, Filippou, Georgios, and Investigators, the STARTER

Subjects
TENOSYNOVITIS, KRUSKAL-Wallis Test, COMBINATION drug therapy, ULTRASONIC imaging, RHEUMATOID arthritis, DESCRIPTIVE statistics, CHI-squared test, DATA analysis software, DISEASE remission, LONGITUDINAL method
Abstract

Objective This study is a sub-analysis from the patient cohort of the STARTER (Sonographic Tenosynovitis Assessment in RheumaToid arthritis patiEnts in Remission) study. The aim was to evaluate differences in ultrasound-detected joint and/or tendon involvement between patients receiving therapies based on a combination of conventional synthetic DMARDs (csDMARDs) and biologic DMARDs (bDMARDs) and those who were treated with either csDMARDs or bDMARDs in monotherapy. Material and methods Four hundred and twenty-seven consecutive patients with a diagnosis of RA were recruited between October 2013 and June 2014. They were divided into three subgroups based on their therapy at baseline: patients with bDMARD in monotherapy, patients with csDMARD in monotherapy and patients in combination therapy (csDMARD + bDMARD). At baseline, 6 months and 12 months, a clinical examination (28 joint count) and an ultrasound evaluation were performed in each patient. A score of grey-scale (GS) and power Doppler (PD) synovitis and tenosynovitis was calculated based on the OMERACT scoring systems. Results Two hundred and fifty-six patients completed the observation period: 48 patients from the bDMARD group (18.75%), 152 patients from the csDMARD group (59.38%) and 56 patients from csDMARD + bDMARD group (21.88%). The analysis showed that GS tenosynovitis and PD tenosynovitis are better controlled in combination therapy than they are with csDMARD alone (P  = 0.025 and P  = 0.047, respectively); for PD synovitis, there was a better response in those who were treated with the combination therapy when compared with the patients receiving csDMARD (P  = 0.01) or bDMARD (P  = 0.02) alone. Conclusions The analysis showed a lower prevalence of subclinical inflammatory manifestations detected with ultrasound imaging in those patients treated with the combination therapy than in those in monotherapy. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Reliability assessment of the definition of ultrasound enthesitis in SpA: results of a large, multicentre, international, web-based study

Author

Di Matteo, Andrea, primary, Cipolletta, Edoardo, additional, Destro Castaniti, Giulia Maria, additional, Smerilli, Gianluca, additional, Airoldi, Carla, additional, Aydin, Sibel Zehra, additional, Becciolini, Andrea, additional, Bonfiglioli, Karina, additional, Bruns, Alessandra, additional, Carrara, Greta, additional, Cazenave, Tomas, additional, Ciapetti, Alessandro, additional, Cosatti, Micaela Ana, additional, de Agustín, Juan José, additional, Di Carlo, Marco, additional, Di Donato, Eleonora, additional, Di Geso, Luca, additional, Duran, Emine, additional, Elliott, Ashley, additional, Estrach, Cristina, additional, Farisogulları, Bayram, additional, Fiorenza, Alessia, additional, Fodor, Daniela, additional, Gabba, Alessandra, additional, Hernández-Díaz, Cristina, additional, Huang, Feng, additional, Hurnakova, Jana, additional, Li, Ling, additional, Jesus, Diogo, additional, Karadag, Omer, additional, Martire, Maria Victoria, additional, Massarotti, Marco, additional, Michelena, Xabier, additional, Musca, Alice Andreea, additional, Nair, Jagdish, additional, Okano, Tadashi, additional, Papalopoulos, Ioannis, additional, Rosemffet, Marcos, additional, Rovisco, João, additional, Rozza, Davide, additional, Salaffi, Fausto, additional, Satulu, Iulia, additional, Scioscia, Crescenzio, additional, Scirè, Carlo Alberto, additional, Sun, Fei, additional, Tamas, Maria-Magdalena, additional, Tanimura, Shun, additional, Ventura-Rios, Lucio, additional, Voulgari, Paraksevi V, additional, Vreju, Florentin Ananu, additional, Vukatana, Gentiana, additional, Wong, Ernest, additional, Yang, Jinshui, additional, Zacariaz Hereter, Johana, additional, Zanetti, Anna, additional, Grassi, Walter, additional, and Filippucci, Emilio, additional

Published
2022
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39. Clinical governance of patients with acute coronary syndromes

Author

Leonardi, Sergio, Montalto, Claudio, Carrara, Greta, Casella, Gianni, Grosseto, Daniele, Galazzi, Marco, Repetto, Alessandra, Tua, Lorenzo, Portolan, Monica, Ottani, Filippo, Galvani, Marcello, Gentile, Leandro, Cardelli, Laura Sofia, De Servi, Stefano, Antonelli, Andrea, De Ferrari, Gaetano Maria, Visconti, Luigi Oltrona, and Campo, Gianluca

Subjects
clinical governance, Time Factors, Humans, acute coronary syndromes, General Medicine, Prospective Studies, Acute Coronary Syndrome, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, Coronary Angiography, quality improvement
Abstract

Aims Using the principles of clinical governance, a patient-centred approach intended to promote holistic quality improvement, we designed a prospective, multicentre study in patients with acute coronary syndrome (ACS). We aimed to verify and quantify consecutive inclusion and describe relative and absolute effects of indicators of quality for diagnosis and therapy. Methods and results Administrative codes for invasive coronary angiography and acute myocardial infarction were used to estimate the ACS universe. The ratio between the number of patients included and the estimated ACS universe was the consecutive index. Co-primary quality indicators were timely reperfusion in patients admitted with ST-elevation ACS and optimal medical therapy at discharge. Cox-proportional hazard models for 1-year death with admission and discharge-specific covariates quantified relative risk reductions and adjusted number needed to treat (NNT) absolute risk reductions. Hospital codes tested had a 99.5% sensitivity to identify ACS universe. We estimated that 7344 (95% CI: 6852–7867) ACS patients were admitted and 5107 were enrolled—i.e. a consecutive index of 69.6% (95% CI 64.9–74.5%), which varied from 30.7 to 79.2% across sites. Timely reperfusion was achieved in 22.4% (95% CI: 20.7–24.1%) of patients, was associated with an adjusted hazard ratio (HR) for 1-year death of 0.60 (95% CI: 0.40–0.89) and an adjusted NNT of 65 (95% CI: 44–250). Corresponding values for optimal medical therapy were 70.1% (95% CI: 68.7–71.4%), HR of 0.50 (95% CI: 0.38–0.66), and NNT of 98 (95% CI: 79–145). Conclusion A comprehensive approach to quality for patients with ACS may promote equitable access of care and inform implementation of health care delivery. Registration ClinicalTrials.Gov ID NCT04255537

Published
2022

40. Additional file 1 of Influence of initial glucocorticoid co-medication on mortality and hospitalization in early inflammatory arthritis: an investigation by record linkage of clinical and administrative databases

Author

Sakellariou, Garifallia, Scirè, Carlo Alberto, Rumi, Federica, Carrara, Greta, Zanetti, Anna, Cerra, Carlo, Migliazza, Simona, Bugatti, Serena, and Montecucco, Carlomaurizio

Subjects
mental disorders
Abstract

Additional file 1: Table S1. ATC codes used to identify treatments in the AHD. Table S2. Codification of comorbidities for the construction of the Charlson comorbidity index and the prevalence of single comorbidities. Table S3. Codification of causes of hospitalization, potentially related to GC treatment. Table S4. Cox regression analysis on mortality including patients dying in the first two years, 2-level definition of corticosteroid treatment, including CCI (non-rheumatologic comorbidities vs rheumatologic comorbidities only). Table S5. Cox regression analysis on mortality, GC included as mean daily dose throughout the follow-up, including CCI (non-rheumatologic comorbidities vs rheumatologic comorbidities only). Table S6. Cox regression analysis on GC-related hospitalization including patients dying in the first two years, 2-level definition of corticosteroid treatment, including CCI (non-rheumatologic comorbidities vs rheumatologic comorbidities only).

Published
2022
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41. Predictors of disease activity in gout: a 12-month analysis of the ATTACk (Achieving improvement in the management of crystal-induced arthritis) multicentre cohort study

Author

Lorenzin, Mariagrazia, primary, Ughi, Nicola, additional, Ariani, Alarico, additional, Raffeiner, Bernd, additional, Frallonardo, Paola, additional, Hoxha, Ariela, additional, Ortolan, Augusta, additional, Favero, Marta, additional, Parisi, Simone, additional, Bortoluzzi, Alessandra, additional, Ceccarelli, Fulvia, additional, Lucchetti, Ramona, additional, Furini, Federica, additional, Del Ross, Teresa, additional, Zanetti, Anna, additional, Carrara, Greta, additional, Scirè, Carlo Alberto, additional, Doria, Andrea, additional, and Ramonda, Roberta, additional

Published
2022
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42. Country-Level Factors Associated With COVID-19-Related Death in People With Rheumatic Disease: Results From the COVID-19 Global Rheumatology Alliance Registry

Author

Izadi, Zara, primary, Gianfrancesco, Milena A., additional, Schmajuk, Gabriela, additional, Jacobsohn, Lindsay, additional, Katz, Patricia, additional, Rush, Stephanie, additional, Ja, Clairissa, additional, Taylor, Tiffany, additional, Shidara, Kie, additional, Danila, Maria I., additional, Wysham, Katherine D., additional, Strangfeld, Anja, additional, Frãzao Mateus, Elsa, additional, Hyrich, Kimme L., additional, Gossec, Laure, additional, Carmona, Loreto, additional, Lawson-Tovey, Saskia, additional, Kearsley-Fleet, Lianne, additional, Schaefer, Martin, additional, Al-Emadi, Samar, additional, Sparks, Jeffrey A., additional, Hsu, Tiffany Y-T, additional, Patel, Naomi J., additional, Wise, Leanna, additional, Gilbert, Emily, additional, Duarte-García, Alí, additional, Valenzuela-Almada, Maria O., additional, Ugarte-Gil, Manuel F., additional, Ljung, Lotta, additional, Scirè, Carlo A., additional, Carrara, Greta, additional, Hachulla, Eric, additional, RICHEZ, Christophe, additional, CACOUB, Patrice, additional, Thomas, Thierry, additional, Santos, Maria J., additional, Bernardes, Miguel, additional, Hasseli, Rebecca, additional, Regierer, Anne, additional, Schulze-Koops, Hendrik, additional, Müller-Ladner, Ulf, additional, Pons-Estel, Guillermo, additional, Tanten, Romina, additional, Nieto, Romina E., additional, Pisoni, Cecilia Nora, additional, Tissera, Yohana S., additional, Xavier, Ricardo, additional, Marques, Claudia D. Lopes, additional, Pileggi, Gecilmara Cristina Salviato, additional, Robinson, Philip C., additional, Machado, Pedro M., additional, Sirotich, Emily, additional, Liew, Jean W., additional, Hausmann, Jonathan S., additional, Sufka, Paul, additional, Grainger, Rebecca, additional, Bhana, Suleman, additional, Gore-Massy, Monique, additional, Wallace, Zachary S., additional, Yazdany, Jinoos, additional, and Registry, Global Rheumatology Alliance, additional

Published
2022
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44. Musculoskeletal ultrasound may narrow the gap between patients and physicians in the assessment of rheumatoid arthritis disease activity.

Author

Floris, Alberto, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Bellis, Emanuela, Cauli, Alberto, Iagnocco, Annamaria, Scirè, Carlo Alberto, Piga, Matteo, and investigators, STARTER

Subjects
TENOSYNOVITIS, STATISTICS, REFERENCE values, SKELETAL muscle, SYNOVITIS, SELF-evaluation, VISUAL analog scale, RHEUMATOLOGISTS, RHEUMATOID arthritis, SYMPTOMS, DESCRIPTIVE statistics, DOPPLER ultrasonography, DATA analysis, LOGISTIC regression analysis, ODDS ratio, DISEASE remission, MEDICAL needs assessment, DISEASE complications
Abstract

Objectives To investigate the association between patient–physician discordance in the assessment of disease activity and residual US synovitis/tenosynovitis in a cohort of patients with RA in clinical remission. Methods A post hoc analysis of the STARTER study, promoted by the Musculoskeletal-US (MSUS) Study Group of the Italian Society for Rheumatology, was performed using data from 361 consecutive patients with RA in clinical remission. The global assessment of disease activity by each patient (PGA) and evaluator/physician (EGA) was recorded on a 100-mm visual analogue scale. The PGA-EGA discordance was classified as positive (PGA>EGA) or negative (PGA

Published
2023
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45. Reliability assessment of the definition of ultrasound enthesitis in SpA: results of a large, multicentre, international, web-based study.

Author

Matteo, Andrea Di, Cipolletta, Edoardo, Castaniti, Giulia Maria Destro, Smerilli, Gianluca, Airoldi, Carla, Aydin, Sibel Zehra, Becciolini, Andrea, Bonfiglioli, Karina, Bruns, Alessandra, Carrara, Greta, Cazenave, Tomas, Ciapetti, Alessandro, Cosatti, Micaela Ana, Agustín, Juan José de, Carlo, Marco Di, Donato, Eleonora Di, Geso, Luca Di, Duran, Emine, Elliott, Ashley, and Estrach, Cristina

Subjects
RELIABILITY (Personality trait), RESEARCH, STATISTICS, BONES, RESEARCH evaluation, CONFIDENCE intervals, JUVENILE idiopathic arthritis, ANKYLOSIS, SPONDYLOARTHROPATHIES, INTER-observer reliability, DOPPLER ultrasonography, DESCRIPTIVE statistics
Abstract

Objectives To investigate the reliability of the OMERACT US Task Force definition of US enthesitis in SpA. Methods In this web exercise, based on the evaluation of 101 images and 39 clips of the main entheses of the lower limbs, the elementary components included in the OMERACT definition of US enthesitis in SpA (hypoechoic areas, entheseal thickening, power Doppler signal at the enthesis, enthesophytes/calcifications, bone erosions) were assessed by 47 rheumatologists from 37 rheumatology centres in 15 countries. Inter- and intra-observer reliability of the US components of enthesitis was calculated using Light's kappa, Cohen's kappa, Prevalence And Bias Adjusted Kappa (PABAK) and their 95% CIs. Results Bone erosions and power Doppler signal at the enthesis showed the highest overall inter-reliability [Light's kappa: 0.77 (0.76–0.78), 0.72 (0.71–0.73), respectively; PABAK: 0.86 (0.86–0.87), 0.73 (0.73–0.74), respectively], followed by enthesophytes/calcifications [Light's kappa: 0.65 (0.64–0.65), PABAK: 0.67 (0.67–0.68)]. This was moderate for entheseal thickening [Light's kappa: 0.41 (0.41–0.42), PABAK: 0.41 (0.40–0.42)], and fair for hypoechoic areas [Light's kappa: 0.37 (0.36–0.38); PABAK: 0.37 (0.37–0.38)]. A similar trend was observed in the intra-reliability exercise, although this was characterized by an overall higher degree of reliability for all US elementary components compared with the inter-observer evaluation. Conclusions The results of this multicentre, international, web-based study show a good reliability of the OMERACT US definition of bone erosions, power Doppler signal at the enthesis and enthesophytes/calcifications. The low reliability of entheseal thickening and hypoechoic areas raises questions about the opportunity to revise the definition of these two major components for the US diagnosis of enthesitis. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Systemic sclerosis Progression INvestiGation (SPRING) Italian registry: demographic and clinico-serological features of scleroderma spectrum

Author

Ferri, Clodoveo, Giuggioli, Dilia, Guiducci, Serena, Lumetti, Federica, Bajocchi, Gianluigi, Magnani, Luca, Codullo, Veronica, Ariani, Alarico, Girelli, Francesco, Riccieri, Valeria, Pellegrino, Greta, Bosello, Silvia, Foti, Rosario, Visalli, Elisa, Amato, Giorgio, Benenati, Alessia, Cuomo, Giovanna, Iannone, Florenzo, Cacciapaglia, Fabio, Angelis, Rossella, Ingegnoli, Francesca, ROSSELLA TALOTTA, Campochiaro, Corrado, Dagna, Lorenzo, Luca, Giacomo, Bellando-Randone, Silvia, Spinella, Amelia, Murdaca, Giuseppe, Romeo, Nicoletta, Santis, Maria, Generali, Elena, Barsotti, Simone, Della Rossa, Alessandra, Cavazzana, Ilaria, Dall Ara, Francesca, Lazzaroni, Maria G., Cozzi, Franco, Andrea Doria, Pigatto, Erika, ELISABETTA ZANATTA, Ciano, Giovanni, Beretta, Lorenzo, Abignano, Giuseppina, D Angelo, Salvatore, Mennillo, Gianna, Bagnato, Gianluca, Calabrese, Francesca, Caminiti, Maurizio, Pagano Mariano, Giuseppa, Battaglia, Elisabetta, Lubrano, Ennio, Zanframundo, Giovanni, Iuliano, Annamaria, Furini, Federica, Zanetti, Anna, Carrara, Greta, Rumi, Federica, Scirè, Carlo Alberto, Matucci-Cerinic, Marco, Ferri, C, Giuggioli, D, Guiducci, S, Lumetti, F, Bajocchi, G, Magnani, L, Codullo, V, Ariani, A, Girelli, F, Riccieri, V, Pellegrino, G, Bosello, S, Foti, R, Visalli, E, Amato, G, Benenati, A, Cuomo, G, Iannone, F, Cacciapaglia, F, De Angelis, R, Ingegnoli, F, Talotta, R, Campochiaro, C, Dagna, L, De Luca, G, Bellando-Randone, S, Spinella, A, Murdaca, G, Romeo, N, De Santis, M, Generali, E, Barsotti, S, Della Rossa, A, Cavazzana, I, Dall'Ara, F, Lazzaroni, M, Cozzi, F, Doria, A, Pigatto, E, Zanatta, E, Ciano, G, Beretta, L, Abignano, G, D'Angelo, S, Mennillo, G, Bagnato, G, Calabrese, F, Caminiti, M, Pagano Mariano, G, Battaglia, E, Lubrano, E, Zanframundo, G, Iuliano, A, Furini, F, Zanetti, A, Carrara, G, Rumi, F, Scirè, C, Matucci-Cerinic, M, Ferri, Clodoveo, Giuggioli, Dilia, Guiducci, Serena, Lumetti, Federica, Bajocchi, Gianluigi, Magnani, Luca, Codullo, Veronica, Ariani, Alarico, Girelli, Francesco, Riccieri, Valeria, Pellegrino, Greta, Bosello, Silvia, Foti, Rosario, Visalli, Elisa, Amato, Giorgio, Benenati, Alessia, Cuomo, Giovanna, Iannone, Florenzo, Cacciapaglia, Fabio, De Angelis, Rossella, Ingegnoli, Francesca, Talotta, Rossella, Campochiaro, Corrado, Dagna, Lorenzo, De Luca, Giacomo, Bellando-Randone, Silvia, Spinella, Amelia, Murdaca, Giuseppe, Romeo, Nicoletta, De Santis, Maria, Generali, Elena, Barsotti, Simone, Della Rossa, Alessandra, Cavazzana, Ilaria, Dall'Ara, Francesca, Lazzaroni, Maria G, Cozzi, Franco, Doria, Andrea, Pigatto, Erika, Zanatta, Elisabetta, Ciano, Giovanni, Beretta, Lorenzo, Abignano, Giuseppina, D'Angelo, Salvatore, Mennillo, Gianna, Bagnato, Gianluca, Calabrese, Francesca, Caminiti, Maurizio, Pagano Mariano, Giuseppa, Battaglia, Elisabetta, Lubrano, Ennio, Zanframundo, Giovanni, Iuliano, Annamaria, Furini, Federica, Zanetti, Anna, Carrara, Greta, Rumi, Federica, Scirè, Carlo Alberto, and Matucci-Cerinic, Marco

Subjects
Male, Scleroderma, Systemic, Settore MED/16 - REUMATOLOGIA, systemic sclerosis, Raynaud’s phenomenon, VEDOSS, Raynaud Disease, Microscopic Angioscopy, Cohort Studies, Systemic sclerosi, Italy, Humans, Registries, Systemic sclerosis
Abstract

Objectives: Systemic sclerosis (SSc) is a severe multiple-organ disease characterised by unpredictable clinical course, inadequate response to treatment, and poor prognosis. National SSc registries may provide large and representative patients cohorts required for descriptive and prognostic studies. Therefore, the Italian Society for Rheumatology promoted the registry SPRING (Systemic sclerosis Progression INvestiGation). Methods: The SPRING is a multi-centre rheumatological cohort study encompassing the wide scleroderma spectrum, namely the primary Raynaud's phenomenon (pRP), suspected secondary RP, Very Early Diagnosis of Systemic Sclerosis (VEDOSS), and definite SSc. Here we describe the demographic and clinical characteristics of a population of 2,028 Italian patients at the initial phase of enrolment, mainly focusing on the cohort of 1,538 patients with definite SSc. Results: Definite SSc showed a significantly higher prevalence of digital ulcers, capillaroscopic 'late' pattern, oesophageal and cardio-pulmonary involvement compared to VEDOSS, as expected on the basis of the followed classification criteria. The in-depth analysis of definite SSc revealed that male gender, diffuse cutaneous subset, and anti-Scl70 seropositivity were significantly associated with increased prevalence of the most harmful disease manifestations. Similarly, patients with very short RP duration (≤1 year) at SSc diagnosis showed a statistically increased prevalence of unfavourable clinico-serological features. Conclusions: Nationwide registries with suitable subsetting of patients and follow-up studies since the prodromal phase of the disease may give us valuable insights into the SSc natural history and main prognostic factors.

Published
2020

47. Similarities and differences between younger and older disease onset patients with newly diagnosed systemic lupus erythematosus

Author

Prevete, Immacolata, primary, Iuliano, Annamaria, additional, Cauli, Alberto, additional, Piga, Matteo, additional, Iannone, Florenzo, additional, Coladonato, Laura, additional, Bortoluzzi, Alessandra, additional, Silvagni, Ettore, additional, Tani, Chiara, additional, Elefante, Elena, additional, Doria, Andrea, additional, Iaccarino, Luca, additional, Franceschini, Franco, additional, Fredi, Micaela, additional, Conti, Fabrizio, additional, Spinelli, Francesca Romana, additional, Frediani, Bruno, additional, Gonzales Garcìa, Estrela, additional, Scirè, Carlo A, additional, Zanetti, Anna, additional, Rozza, Davide, additional, Carrara, Greta, additional, and Sebastiani, Gian Domenico, additional

Published
2021
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49. Intestinal microbiota changes induced by TNF-inhibitors in IBD-related spondyloarthritis

Author

Ditto, Maria Chiara, primary, Parisi, Simone, additional, Landolfi, Gianpiero, additional, Borrelli, Richard, additional, Realmuto, Cristina, additional, Finucci, Annacarla, additional, Caviglia, Gian Paolo, additional, Ribaldone, Davide Giuseppe, additional, Astegiano, Marco, additional, Zanetti, Anna, additional, Carrara, Greta, additional, Scirè, Carlo Alberto, additional, Antivalle, Marco, additional, Sarzi-Puttini, Piercarlo, additional, and Fusaro, Enrico, additional

Published
2021
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50. Cost‐Effectivenessof the Early Arthritis Clinic Organizational Model

Author

Zanetti, Anna, Sakellariou, Garifallia, Zambon, Antonella, Carrara, Greta, Argnani, Lisa, Mantovani, Lorenzo G., Cortesi, Paolo A., Bugatti, Serena, Montecucco, Carlomaurizio, and Scirè, Carlo A.

Abstract

Early diagnosis and tight control improve outcomes of rheumatoid arthritis (RA). However, whether establishing an early arthritis clinic (EAC) is sustainable for national health systems is not known. This analysis aimed to compare effectiveness and costs of an EAC compared to patients followed by the current standard of care. A retrospective study on administrative health databases of patients with a new diagnosis of RA was conducted: 430 patients followed in an EAC were enrolled, and 4 non‐EAC controls were randomly matched for each. During 2 years of follow‐up, the mean health care costs (outpatient, inpatient, pharmaceutical, and global) and 3 effectiveness measures (number and length of hospitalization and quality of care) of the EAC and non‐EAC were estimated. The incremental cost‐effectiveness ratio was calculated as well as the cost‐effectiveness acceptability curve. The cohorts included patients with a mean age of 55.4 years, and 1,506 patients (70%) were female. The mean pharmaceutical (2,602 versus 1,945 euros) and outpatient (2,447 versus 1,778 euros) costs were higher in the EAC cohort. Conversely, a higher rate of non‐EAC patients had a low adherence to quality‐of‐care indicators. The expected number of hospitalizations and the length of stay were statistically significantly higher in the non‐EAC versus EAC. Despite an expected increase in outpatient costs (visits and diagnostic tests) and pharmaceutical costs, the reduction in terms of number and length of hospitalizations and the higher adherence to international quality‐of‐care guidelines support the effectiveness of the EAC model.

Published
2023
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