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34 results on '"Campos, Jonas"'

1. Secretome of bone marrow mesenchymal stromal cells cultured in a dynamic system induces neuroprotection and modulates microglial responsiveness in an α-synuclein overexpression rat model

Author

Marques, Cláudia Raquel, Campos, Jonas, Sampaio-Marques, Belém, Antunes, Filipa Ferreira, dos Santos Cunha, Raquel Medina, Silva, Deolinda, Barata-Antunes, Sandra, Lima, Rui, Fernandes-Platzgummer, Ana, da Silva, Cláudia L., Sousa, Rui Amandi, and Salgado, António José

Published
2024
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3. Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3

Author

Duarte-Silva, Sara, Da Silva, Jorge Diogo, Monteiro-Fernandes, Daniela, Costa, Marta Daniela, Neves-Carvalho, Andreia, Raposo, Mafalda, Soares-Cunha, Carina, Correia, Joana S., Nogueira- Goncalves, Goncalo, Fernandes, Henrique S., Oliveira, Stephanie, Ferreira-Fernandes, Ana Rita, Rodrigues, Fernando, Pereira-Sousa, Joana, Vilasboas-Campos, Daniela, Guerreiro, Sara, Campos, Jonas, Meireles- Costa, Liliana, Rodrigues, Cecilia M.P., Cabantous, Stephanie, Sousa, Sergio F., Lima, Manuela, Teixeira-Castro, Andreia, and Maciel, Patricia

Subjects
Thermo Fisher Scientific Inc., Medical research -- Models -- Health aspects, Medicine, Experimental -- Models -- Health aspects, Nematoda -- Models -- Health aspects, Scientific equipment and supplies industry -- Health aspects -- Models, Corticosteroids -- Health aspects -- Models, Spinocerebellar ataxia -- Models -- Health aspects, Bile acids -- Models -- Health aspects, Genes -- Models -- Health aspects, Proteolysis -- Health aspects -- Models, Nervous system diseases -- Health aspects -- Models, Health care industry
Abstract

Spinocerebellar ataxia type 3 (SCA3) is an adult-onset neurodegenerative disease caused by a polyglutamine expansion in the ataxin-3 (ATXN3) gene. No effective treatment is available for this disorder, other than symptom-directed approaches. Bile acids have shown therapeutic efficacy in neurodegenerative disease models. Here, we pinpointed tauroursodeoxycholic acid (TUDCA) as an efficient therapeutic, improving the motor and neuropathological phenotype of SCA3 nematode and mouse models. Surprisingly, transcriptomic and functional in vivo data showed that TUDCA acts in neuronal tissue through the glucocorticoid receptor (GR), but independently of its canonical receptor, the farnesoid X receptor (FXR). TUDCA was predicted to bind to the GR, in a similar fashion to corticosteroid molecules. GR levels were decreased in disease-affected brain regions, likely due to increased protein degradation as a consequence of ATXN3 dysfunction being restored by TUDCA treatment. Analysis of a SCA3 clinical cohort showed intriguing correlations between the peripheral expression of GR and the predicted age at disease onset in presymptomatic subjects and FKBP5 expression with disease progression, suggesting this pathway as a potential source of biomarkers for future study. We have established a novel in vivo mechanism for the neuroprotective effects of TUDCA in SCA3 and propose this readily available drug for clinical trials in SCA3 patients., Introduction Neurodegenerative diseases are currently considered a growing epidemic in the aging population (1, 2), still lacking effective therapeutic options. For those disorders with an identified genetic cause, research has [...]

Published
2024
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4. Cellular Aging Secretes: a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture

Author

Marote, Ana, Santos, Diogo, Mendes-Pinheiro, Bárbara, Serre-Miranda, Cláudia, Anjo, Sandra I., Vieira, Joana, Ferreira-Antunes, Filipa, Correia, Joana Sofia, Borges-Pereira, Caroline, Pinho, Andreia G., Campos, Jonas, Manadas, Bruno, Teixeira, Manuel R., Correia-Neves, Margarida, Pinto, Luísa, Costa, Pedro M., Roybon, Laurent, and Salgado, António J.

Published
2023
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6. The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol

Author

Lentilhas-Graça, José, primary, Santos, Diogo J., additional, Afonso, João, additional, Monteiro, Andreia, additional, Pinho, Andreia G., additional, Mendes, Vera M., additional, Dias, Marta S., additional, Gomes, Eduardo D., additional, Lima, Rui, additional, Fernandes, Luís S., additional, Fernandes-Amorim, Fernando, additional, Pereira, Inês M., additional, de Sousa, Nídia, additional, Cibrão, Jorge R., additional, Fernandes, Aline M., additional, Serra, Sofia C., additional, Rocha, Luís A., additional, Campos, Jonas, additional, Pinho, Tiffany S., additional, Monteiro, Susana, additional, Manadas, Bruno, additional, Salgado, António J., additional, Almeida, Ramiro D., additional, and Silva, Nuno A., additional

Published
2024
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8. Adipose tissue derived stem cell secretome induces motor and histological gains after complete spinal cord injury in Xenopus laevis and mice

Author

Assunção-Silva, Rita C, primary, Pinho, Andreia, additional, Cibrão, Jorge R, additional, Pereira, Inês M, additional, Monteiro, Susana, additional, Silva, Nuno A, additional, Campos, Jonas, additional, Rebelo, Ana L, additional, Schlosser, Gerhard, additional, Pinto, Luisa, additional, Pandit, Abhay, additional, and Salgado, António J, additional

Published
2024
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9. Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration

Author

Mendes-Pinheiro, Bárbara, primary, Campos, Jonas, additional, Marote, Ana, additional, Soares-Cunha, Carina, additional, Nickels, Sarah L., additional, Monzel, Anna S., additional, Cibrão, Jorge R., additional, Loureiro-Campos, Eduardo, additional, Serra, Sofia C., additional, Barata-Antunes, Sandra, additional, Duarte-Silva, Sara, additional, Pinto, Luísa, additional, Schwamborn, Jens C., additional, and Salgado, António J., additional

Published
2023
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11. Neurodifferentiation and Neuroprotection Potential of Mesenchymal Stromal Cell-Derived Secretome Produced in Different Dynamic Systems

Author

Marques, Cláudia Raquel, primary, Fuzeta, Miguel de Almeida, additional, dos Santos Cunha, Raquel Medina, additional, Pereira-Sousa, Joana, additional, Silva, Deolinda, additional, Campos, Jonas, additional, Teixeira-Castro, Andreia, additional, Sousa, Rui Amandi, additional, Fernandes-Platzgummer, Ana, additional, da Silva, Cláudia L., additional, and Salgado, António José, additional

Published
2023
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12. Cerebral Malaria Model Applying Human Brain Organoids

Author

Silva-Pedrosa, Rita, primary, Campos, Jonas, additional, Fernandes, Aline Marie, additional, Silva, Miguel, additional, Calçada, Carla, additional, Marote, Ana, additional, Martinho, Olga, additional, Veiga, Maria Isabel, additional, Rodrigues, Ligia R., additional, Salgado, António José, additional, and Ferreira, Pedro Eduardo, additional

Published
2023
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13. Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury

Author

de Sousa, Nidia, primary, Robledo, Diego, additional, González-Llera, Laura, additional, Pinho, Andreia G., additional, Santos, Diogo J., additional, Monteiro, Susana, additional, Campos, Jonas, additional, Cibrão, Jorge R., additional, Silva, Nuno A., additional, Sánchez, Laura, additional, Salgado, António J., additional, and Barreiro-Iglesias, Antón, additional

Published
2023
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14. Cerebral malaria model applying human brain organoids

Author

Pedrosa, Ana Rita Silva, Campos, Jonas Oliveira, Fernandes, Aline Marie, Silva, Miguel, Calçada, Carla Sofia Martins, Marote, Ana Maria Franco Aveiro, Martinho, Olga, Veiga, Maria Isabel, Rodrigues, L. R., Salgado, A. J., Ferreira, Pedro Eduardo Mendes, and Universidade do Minho

Subjects
Brain organoids, Science & Technology, Human iPSCs, Transcriptome, Cerebral malaria, HBMEC activation, Secretome
Abstract

Neural injuries in cerebral malaria patients are a significant cause of morbidity and mortality. Nevertheless, a comprehensive research approach to study this issue is lacking, so herein we propose an in vitro system to study human cerebral malaria using cellular approaches. Our first goal was to establish a cellular system to identify the molecular alterations in human brain vasculature cells that resemble the blood–brain barrier (BBB) in cerebral malaria (CM). Through transcriptomic analysis, we characterized specific gene expression profiles in human brain microvascular endothelial cells (HBMEC) activated by the Plasmodium falciparum parasites. We also suggest potential new genes related to parasitic activation. Then, we studied its impact at brain level after Plasmodium falciparum endothelial activation to gain a deeper understanding of the physiological mechanisms underlying CM. For that, the impact of HBMEC-P. falciparum-activated secretomes was evaluated in human brain organoids. Our results support the reliability of in vitro cellular models developed to mimic CM in several aspects. These systems can be of extreme importance to investigate the factors (parasitological and host) influencing CM, contributing to a molecular understanding of pathogenesis, brain injury, and dysfunction., This research was funded by National funds through the Foundation for Science and Technology (FCT) SFRH/BD/131540/2017, SFRH/BD/5813/2020, COVID/BD/152416/2022 and UMINHO/BIM-CNCG/2022/143. This work has been funded by ICVS Scientific Microscopy Platform, member of the national infrastructure PPBI - Portuguese Platform of Bioimaging (PPBIPOCI-01-0145-FEDER-022122; by National funds, through the FCT—project UIDB/50026/2020 and UIDP/50026/2020. Moreover, this work was funded by IF/00143/2015/CP1294/CT0001, PTDC/SAU-PAR/2766/2021 and UIDB/04469/2020. O.M. is funded by the project NORTE-01- 0247-FEDER-045914, supported by POFC–COMPETE and FCT, under the programs PT2020 and NORTE2020. M.I.V. thanks FCT for her contract funding provided through 2020.03113.CEECIND., info:eu-repo/semantics/publishedVersion

Published
2023

16. Cellular Aging Secretes: a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture

Author

Marote, Ana, primary, Santos, Diogo, additional, Mendes-Pinheiro, Bárbara, additional, Serre-Miranda, Cláudia, additional, Anjo, Sandra I., additional, Vieira, Joana, additional, Ferreira-Antunes, Filipa, additional, Correia, Joana Sofia, additional, Borges-Pereira, Caroline, additional, Pinho, Andreia G., additional, Campos, Jonas, additional, Manadas, Bruno, additional, Teixeira, Manuel R., additional, Correia-Neves, Margarida, additional, Pinto, Luísa, additional, Costa, Pedro M., additional, Roybon, Laurent, additional, and Salgado, António J., additional

Published
2022
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20. Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury

Author

Universidade de Santiago de Compostela. Departamento de Bioloxía Funcional, Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física, Sousa, Nidia de, Robledo Sánchez, Diego, González Llera, Laura, Pinho, Andreia G., Santos, Diogo J., Monteiro, Susana, Campos, Jonas, Cibrão, Jorge R., Silva, Nuno A., Sánchez Piñón, Laura Elena, Salgado, António J., Barreiro Iglesias, Antón, Universidade de Santiago de Compostela. Departamento de Bioloxía Funcional, Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física, Sousa, Nidia de, Robledo Sánchez, Diego, González Llera, Laura, Pinho, Andreia G., Santos, Diogo J., Monteiro, Susana, Campos, Jonas, Cibrão, Jorge R., Silva, Nuno A., Sánchez Piñón, Laura Elena, Salgado, António J., and Barreiro Iglesias, Antón

Abstract

Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments to promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can promote functional recovery after a compression SCI in mice [1]. Here, we provide transcriptomic (RNA-seq) data from adult mouse spinal cords collected 7 days after a compression SCI and baclofen (vs vehicle) administration. The Illumina NovaSeq 6000 platform was used to generate the raw transcriptomic data. In addition, we also present bioinformatic analyses including differential gene expression analysis, enrichment analyses for various functional annotations (gene ontology, KEGG and BioCarta pathways or InterPro domains) and transcription factor targets. The raw RNA-seq data has been uploaded to the NCBI Sequence Read Archive (SRA) database (Bioproject ID PRJNA886048). The data generated from the bioinformatic analyses is contained within the article

Published
2022

21. Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response

Author

Mendes-Pinheiro, Bárbara, primary, Soares-Cunha, Carina, additional, Marote, Ana, additional, Loureiro-Campos, Eduardo, additional, Campos, Jonas, additional, Barata-Antunes, Sandra, additional, Monteiro-Fernandes, Daniela, additional, Santos, Diogo, additional, Duarte-Silva, Sara, additional, Pinto, Luísa, additional, and José Salgado, António, additional

Published
2021
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23. Fractionating stem cells secretome for Parkinson's disease modeling: Is it the whole better than the sum of its parts?

Author

Vilaça-Faria, Helena, primary, Marote, Ana, additional, Lages, Inês, additional, Ribeiro, Clarisse, additional, Mendes-Pinheiro, Bárbara, additional, Domingues, Ana Verónica, additional, Campos, Jonas, additional, Lanceros-Mendez, Senentxu, additional, Salgado, António J., additional, and Teixeira, Fábio G., additional

Published
2021
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26. Nutritional interventions for spinal cord injury: preclinical efficacy and molecular mechanisms.

Author

Campos, Jonas, Silva, Nuno A, and Salgado, António J

Subjects
*NEUROLOGICAL disorder prevention, *DRUG efficacy, *PROTEINS, *HOMEOSTASIS, *SPINAL cord injuries, *PHENOLS, *NEUROPLASTICITY, *METABOLISM, *REDUCING diets, *DIET therapy, *MOLECULAR biology, *NEUROPROTECTIVE agents, *OMEGA-3 fatty acids, *PLANT extracts, *MEDICAL research, *DISEASE complications
Abstract

Spinal cord injury (SCI) is a debilitating condition that leads to motor, sensory, and autonomic impairments. Its intrinsic pathophysiological complexity has hindered the establishment of effective treatments for decades. Nutritional interventions (NIs) for SCI have been proposed as a route to circumvent some of the problems associated with this condition. Results obtained in animal models point to a more holistic effect, rather than to specific modulation, of several relevant SCI pathophysiological processes. Indeed, published data have shown NI improves energetic imbalance, oxidative damage, and inflammation, which are promoters of improved proteostasis and neurotrophic signaling, leading ultimately to neuroprotection and neuroplasticity. This review focuses on the most well-documented Nis. The mechanistic implications and their translational potential for SCI are discussed. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Indoor Dust as a Source of Virulent Strains of the Agents of Cryptococcosis in the Rio Negro Micro-Region of the Brazilian Amazon

Author

Brito-Santos, Fábio, primary, Trilles, Luciana, additional, Firacative, Carolina, additional, Wanke, Bodo, additional, Carvalho-Costa, Filipe Anibal, additional, Nishikawa, Marília Martins, additional, Pereira Campos, Jonas, additional, Junqueira, Angela Cristina Veríssimo, additional, Souza, Amanda Coutinho de, additional, dos Santos Lazéra, Márcia, additional, and Meyer, Wieland, additional

Published
2020
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30. BIOMARCADORES HISTOLÓGICOS EM BRÂNQUIAS DE PEIXES NA AVALIAÇÃO DA CONTAMINAÇÃO AMBIENTAL DO RIO MEARIM, NORDESTE BRASILEIRO / HISTOLOGICAL BIOMARKERS IN FISH GILLS IN THE ASSESSMENT OF ENVIRONMENTAL CONTAMINATION OF THE MEARIM RIVER, NORTHEASTERN BRAZIL

Author

Pereira, Natália Jovita, primary, Santos, Margareth Marques dos, additional, Maião, Jakeline Priscila Lima da Silva, additional, Campos, Jonas Silva de Pinho, additional, Silva, Nayara Duarte da, additional, Mendes, Denise Carla da Silva, additional, Lenz, Tiago de Moraes, additional, and Santos, Débora Martins Silva, additional

Published
2020
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31. O impacto da sinalização astrocítica nos efeitos terapêuticos do secretoma de células mesenquimais estaminais no sistema nervoso central

Author

Campos, Jonas de Oliveira, Salgado, António José Braga Osório Gomes, and Baltazar, Graça Maria Fernandes

Subjects
Célula Estaminal Mesenquimatosa, Ciências Naturais::Ciências Químicas [Domínio/Área Científica], Astrócitos, Secretoma, Morfologia, Proliferação
Abstract

Made available in DSpace on 2020-03-18T17:03:03Z (GMT). No. of bitstreams: 1 7149_15539.pdf: 3361275 bytes, checksum: 03e729172f8dbe8ad83c65b113545c47 (MD5) Previous issue date: 2019-07-24

Published
2019

32. Evaluation of environmental quality of two estuaries in Ilha do Maranhão, Brazil, using histological and genotoxic biomarkers in Centropomus undecimalis (Pisces, Centropomidae)

Author

Cantanhêde, Sildiane Martins, primary, da Silva Castro, Geane, additional, Pereira, Natália Jovita, additional, de Pinho Campos, Jonas Silva, additional, da Silva, Juliana, additional, Tchaicka, Lígia, additional, Neta, Raimunda Nonata Fortes Carvalho, additional, de Souza Torres, José Ribamar, additional, and Santos, Débora Martins Silva, additional

Published
2016
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33. Cadastro único : uma visão de sua adequação à política de assistência social no município de Londrina

Author

Liz Clara de Campos Jonas, Evaristo Emigdio Colmán Duarte ., Maria Carmelita Yazbeck, and Sandra Regina de Abreu Pires

Abstract

Este trabalho compreende um estudo documental acerca do Cadastro Único, banco de dados criado no governo FHC para facilitar a implementação das políticas sociais. Nele, pretende-se refletir acerca do cadastro, não como um fim em si mesmo, mas como meio utilizado para a implementação da Política de Assistência Social. O objeto do estudo é a análise da adequação do Cadastro Único à Política de Assistência Social no município de Londrina desde sua implantação. No trabalho também se analisa a relação entre a política de assistência social e a reforma do Estado, visto que esta reforma, ocorrida no Brasil nos anos 90, interferiu na condução desta política. Finalmente, outro aspecto importante da pesquisa é a analise do Cadastro do ponto de vista da sua lógica de operação: centralização, acesso, transparência. O que se pode concluir até o momento de finalização deste estudo é que o 'cadunico' ainda não se constitui em um instrumento útil na implementação da Política de Assistência Social. This research consists in a documentary study about Cadastro Único, a database created during the FHC government in order to facilitate the social politics implementation. It intends to cause a reflection about the database as a resource used for the Social Assistance Politics implementation. This study objective is the analysis of the database suitability to the Social Assistance Politics in Londrina-PR since its application. This study also analyses the relation between the Social Assistance Politics and the State Reformulation, considering that this reformulation, which occured in Brazil during the decade of 1990, interfered in the Politics conduction. Finally, another important aspect of the research is the analysis of Cadastro Único operation guidelines: centralization, access and transparency. The conclusion up to the moment this study is performed is that the 'cadúnico' has not yet become an useful instrument for the Social Assistance Politics implementation.

Published
2006

34. Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury.

Author

de Sousa N, Robledo D, González-Llera L, Pinho AG, Santos DJ, Monteiro S, Campos J, Cibrão JR, Silva NA, Sánchez L, Salgado AJ, and Barreiro-Iglesias A

Abstract

Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments to promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can promote functional recovery after a compression SCI in mice [1]. Here, we provide transcriptomic (RNA-seq) data from adult mouse spinal cords collected 7 days after a compression SCI and baclofen (vs vehicle) administration. The Illumina NovaSeq 6000 platform was used to generate the raw transcriptomic data. In addition, we also present bioinformatic analyses including differential gene expression analysis, enrichment analyses for various functional annotations (gene ontology, KEGG and BioCarta pathways or InterPro domains) and transcription factor targets. The raw RNA-seq data has been uploaded to the NCBI Sequence Read Archive (SRA) database (Bioproject ID PRJNA886048). The data generated from the bioinformatic analyses is contained within the article., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022 The Author(s).)

Published
2022
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