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Purpose: The purpose of our study was too assess the diagnostic value of red cell distribution width and other inflammatory markers such as white blood cell count and mean platelet volume during the first trimester of gestation for predicting the subsequent development of preeclampsia.Material and Methods: A retrospective study was performed on 137 patients with preeclampsia and 150 normotensive pregnant women. Study group was assessed for presence of preeclampsia and the values of first trimester red cell distribution width, white blood cell count and mean platelet volume. The receiver operator curve was used to evaluate cut-off, sensitivity and specificity values.Results: The optimal cut-off points to predict preeclampsia were a white blood cell count 10200 cells/mm3 or higher with a sensitivity of 75.1% and specificity of 44.1%, a mean platelet volume 8.6fL or lower with a sensitivity of 62.5% and specificity of 64.4% and a red cell distribution width 15.3% or lower with a sensitivity of 31.2% and specificity of 79.7%.Conclusion: Regarding the association between first trimester red cell distribution width, white blood cell count and mean platelet volume, statistical analysis revealed that these markers were weak predictors of preeclampsia

Purpose: The purpose of our study was to investigate whether maternal serum levels of androgens, especially testosterone, are higher in patients with preeclampsia than in matched normotensive control subjects.Material and Methods: A prospective study was performed on 67 preeclamptic patients and 51 normotensive pregnant women. Study group was assessed for presence of preeclampsia and the values of serum free testosterone and dehydroepiandrosterone sulfate. The receiver operator curve was used to evaluate cut-off, sensitivity and specificity values. Results: Free testosterone levels were significantly higher in patients with preeclampsia (2.36±1.2 pg/ml) than the control group (1.62±0.96 pg/ml) but there was no significant difference in dehydroepiandrosterone sulfate levels. The optimal cut-off point to predict preeclampsia was a 2.025 pg/ml or higher levels for free testosteron with a sensitivity of 56%, specificity of 78.4%, positive predictive value of 71.8%, negative predictive value of 64.5% and with a likelihood ratio of 2.6.Discussion: Levels of the potent androgen free testosterone were significantly higher in women with preeclampsia than in normotensive women with similar maternal ages. Although the statistical analysis revealed that these markers were weak predictors of preeclampsia to be used in clinical practice the difference may indicate a role for testosterone in the pathogenesis of preeclampsia.

OBJECTIVE: Diagnostic value of the umbilical cord thickness second trimester congenital anomaly screening. STUDY DESIGN: Eighty-three pregnant women in the study. Patients were examined by dividing them into 3 groups. The first group was comprised of 50 healthy individuals which exhibited no chromosomal or sonographic fetal anomaly. The second group consisted of 8 cases which displayed chromosomal anomaly by amniocentesis. The third group included 25 cases with fetal anomaly detected by USG. RESULTS: The first group mean cord diameter was 7.06±1.6 mm (4.50-11.80 mm). Second group was 8.32±2.2 mm (4.60-11.0 mm), third group was 7.24±1.5 mm (4.70-10.50). No significant difference was determined between the results (p>0.05). CONCLUSION: Umbilical cord diameter was not found to be a valuable sonographic finding in the congenital anomaly screening.

Histopathologic results and clinical course of the sarcomatoid-type vulvar squamous cell carcinoma presenting skin metastasis which is an uncommon entity. Patient presented a nodular lesion of 1cm diameter in right labium minus. Pathology results revealed squamous cell carcinoma. Radical vulvectomy, bilateral inguinofemoral lymphadenectomy were applied to the case. Sarcomatoid squamous cell carcinoma and metastasis in the lymph nodes. Postoperative radiotherapy was applied. The patient again presented 4 months later due to a nodular lesion in the inguinal region. Squamous cell carcinoma displaying sarcomatoid alterations in the dermis. the case was subjected to extended field radiotherapy and cisplatin chemotherapy. The patient’s condition deteriorated postoperative 5th month. Survival rate for skin metastasis of sarcomatoid squamous cell carcinoma in vulva, is found to be poor.