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169 results on '"Breidahl, William"'

12. Baseline indices of iron load predict severity of arthropathy in C282Y homozygous HFE haemochromatosis

Author

Chen, James J., Carroll, Graeme J., Breidahl, William, Olynyk, John K., Chen, James J., Carroll, Graeme J., Breidahl, William, and Olynyk, John K.

Abstract

Objective: To determine the relationship between baseline indices of iron load and severity of arthropathy in C282Y homozygous HFE haemochromatosis (HH). Method: Genetically proven HH participants from a previous community-based study who had clinical and radiologically confirmed arthropathy compatible with HH were included. The most recent joint imaging and blood tests available up to November 2021 were used to assess the summative joint damage score (SJDS), which comprises the sum of radiological grades in all clinically affected joints and all joints in the hands. Relevant x-rays were examined by both a rheumatologist and musculoskeletal radiologist. Joint scores were assigned in keeping with published systems of classification. Discrepancies were resolved by consensus. Results: Nineteen participants with HH and arthropathy (median age 55 years) were analysed. Statistically significant correlations were observed between SJDS and serum ferritin at diagnosis of HH and between SJDS and the red cell mean corpuscular volume (MCV) at diagnosis of HH, [r = 0.58, p = 0.01 and r = 0.474, p = 0.04, respectively]. There was no statistically significant correlation between transferrin saturation at diagnosis and SJDS. Neither current ferritin nor current transferrin saturation were found to correlate with SJDS. Conclusion: Indices of iron metabolism at the time of HH diagnosis and, in particular, serum ferritin concentrations and elevation of the MCV were found to be associated with the radiological severity of HH arthropathy. This finding suggests that baseline iron load is a prognostic marker for joint disease severity and that ferritin concentration at diagnosis is likely to be mechanistically important in the development of chondral damage.

Published
2022

15. Eight-Week Return to Play Following Latarjet Shoulder Reconstruction in an Australian Football Player: A Case Report.

Author

Murphy, Myles, Stockden, Marshall, Withers, Ken, Breidahl, William, and Charlesworth, Jonathon

Subjects
PSYCHOLOGY of athletes, ATHLETIC ability, FOOTBALL injuries, FRACTURE fixation, PATIENT aftercare, JOINT hypermobility, RANGE of motion of joints, MAGNETIC resonance imaging, MEDICAL rehabilitation, MUSCLE strength, SELF-evaluation, SHOULDER injuries, SHOULDER dislocations, SPORTS injuries, PLASTIC surgery, T-test (Statistics), TIME, DISEASE relapse, SPORTS participation, DESCRIPTIVE statistics
Abstract

Introduction: Anterior shoulder dislocation is a common injury in many sports, resulting in extended time lost from play with an extremely high recurrence rate in young athletes playing a high-risk sport. Latarjet shoulder reconstruction is a common surgical procedure used to prevent subsequent dislocation with an expected rehabilitation time frame of between 4 and 6 months before return to play. Case Description: A 21-year-old male Australian football player experienced 2 left-sided shoulder dislocations before undergoing a left Latarjet shoulder reconstruction. He was assessed clinically and with magnetic resonance imaging, which revealed significant tearing of the anterior labrum. The authors theorized that maximal glenohumeral stability occurs after bony healing of the coracoid onto the glenoid at 6 weeks. The patient then underwent an 8-week structured and graduated rehabilitation program aimed at preventing loss of shoulder range of motion, muscle, and functional capacity and returned to play at 8 weeks postinjury with no complications or recurrence at 12-month follow-up. Discussion: This is the first time an 8-week rehabilitation following Latarjet shoulder reconstruction has been reported. In athletes with anterior glenohumeral dislocation who require accelerated return to play, a Latarjet reconstruction with an 8-week rehabilitation protocol may be considered. [ABSTRACT FROM AUTHOR]

Published
2019
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23. Haemochromatosis

Author

Carroll, Graeme J., primary, Breidahl, William H., additional, and Olynyk, John K., additional

Published
2013
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