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422 results on '"Brandt, Jens"'

2. Commitment in the German Banking and Consulting Industry: Influence of Different Leadership Styles on Employee Commitment

Author

Zerner Vinzent, Marten Eckhard, and Brandt Jens

Subjects
leadership, commitment, demographic change, banking, consulting, m12, m54, Management information systems, T58.6-58.62, Business, HF5001-6182
Abstract

Purpose: The success of a firm often largely depends on its employees. Therefore, we propose and test the possibility of influencing affective and normative commitment by transactional, transformational, and passive leadership styles.

Published
2021
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7. Constructive Polychronous Systems

Author

Talpin, Jean-Pierre, Brandt, Jens, Gemünde, Mike, Schneider, Klaus, Shukla, Sandeep, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Artemov, Sergei, editor, and Nerode, Anil, editor

Published
2013
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10. Formal Reasoning About Causality Analysis

Author

Brandt, Jens, Schneider, Klaus, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Mohamed, Otmane Ait, editor, Muñoz, César, editor, and Tahar, Sofiène, editor

Published
2008
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12. Dependable Polygon-Processing Algorithms for Safety-Critical Embedded Systems

Author

Brandt, Jens, Schneider, Klaus, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Yang, Laurence T., editor, Amamiya, Makoto, editor, Liu, Zhen, editor, Guo, Minyi, editor, and Rammig, Franz J., editor

Published
2005
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13. Using Three-Valued Logic to Specify and Verify Algorithms of Computational Geometry

Author

Brandt, Jens, Schneider, Klaus, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Lau, Kung-Kiu, editor, and Banach, Richard, editor

Published
2005
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17. Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model

Author

Przybylski, Grzegorz K., primary, Korsak, Dorota, additional, Iżykowska, Katarzyna, additional, Nowicka, Karina, additional, Zalewski, Tomasz, additional, Tubacka, Małgorzata, additional, Mosor, Maria, additional, Januszkiewicz-Lewandowska, Danuta, additional, Frydrychowicz, Magdalena, additional, Boruczkowski, Maciej, additional, Dworacki, Grzegorz, additional, van den Brandt, Jens, additional, Grabarczyk, Piotr, additional, Schmidt, Christian A., additional, Zeng, Chengwu, additional, and Li, Yangqiu, additional

Published
2022
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19. A Quantitative General Population Job Exposure Matrix for Occupational Noise Exposure

Author

Stokholm, Zara Ann, Erlandsen, Mogens, Schlünssen, Vivi, Basinas, Ioannis, Bonde, Jens Peter, Peters, Susan, Brandt, Jens, Vestergaard, Jesper Medom, Kolstad, Henrik Albert, IRAS OH Epidemiology Chemical Agents, and IRAS OH Epidemiology Chemical Agents

Subjects
Mixed effects model, Epidemiology, Hearing loss, Job-exposure matrix, Population, 010501 environmental sciences, 01 natural sciences, Job, 03 medical and health sciences, 0302 clinical medicine, job exposure matrix for occupational noise exposure, mixed effects model, noise exposure, Risk Factors, job exposure matrix (JEM), Occupational Exposure, Environmental health, epidemiological studies, occupational noise exposure, medicine, Occupational noise exposure, Humans, Industry, Job exposure matrix for occupational noise exposure, Noise dosimeter, occupational, 030212 general & internal medicine, Occupations, education, 0105 earth and related environmental sciences, Epidemiological studies, education.field_of_study, Job exposure matrix (JEM), Public Health, Environmental and Occupational Health, Variance (accounting), International Standard Classification of Occupations, Random effects model, Occupational, job, Noise, Noise, Occupational, epidemiology, medicine.symptom, Psychology, Noise exposure
Abstract

Occupational noise exposure is a known risk factor for hearing loss and also adverse cardiovascular effects have been suggested. A job exposure matrix (JEM) would enable studies of noise and health on a large scale. The objective of this study was to create a quantitative JEM for occupational noise exposure assessment of the general working population. Between 2001–2003 and 2009–2010, we recruited workers from companies within the 10 industries with the highest reporting of noise-induced hearing loss according to the Danish Working Environment Authority and in addition workers of financial services and children day care to optimize the range in exposure levels. We obtained 1343 personal occupational noise dosimeter measurements among 1140 workers representing 100 different jobs according to the Danish version of the International Standard Classification of Occupations 1988 (DISCO 88). Four experts used 35 of these jobs as benchmarks and rated noise levels for the remaining 337 jobs within DISCO 88. To estimate noise levels for all 372 jobs, we included expert ratings together with sex, age, occupational class, and calendar year as fixed effects, while job and worker were included as random effects in a linear mixed regression model. The fixed effects explained 40% of the total variance: 72% of the between-jobs variance, −6% of the between-workers variance and 4% of the within-worker variance. Modelled noise levels showed a monotonic increase with increasing expert score and a 20 dB difference between the highest and lowest exposed jobs. Based on the JEM estimates, metal wheel-grinders were among the highest and finance and sales professionals among the lowest exposed. This JEM of occupational noise exposure can be used to prioritize preventive efforts of occupational noise exposure and to provide quantitative estimates of contemporary exposure levels in epidemiological studies of health effects potentially associated with noise exposure.

Published
2020

28. A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity

Author

Lodygin, Dmitri, Odoardi, Francesca, Schlager, Christian, Korner, Henrike, Kitz, Alexandra, Nosov, Michail, Brandt, Jens van den, Reichardt, Holger M., Haberl, Michael, and Flugel, Alexander

Subjects
T cells -- Physiological aspects -- Genetic aspects -- Research, Autoimmunity -- Development and progression -- Genetic aspects -- Research, DNA binding proteins -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) that is initiated when self-reactive T cells enter the brain and become locally activated after encountering their specific [...]

Published
2013
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30. The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene

Author

Waddell, David S., Baehr, Leslie M., van den Brandt, Jens, Johnsen, Steven A., Reichardt, Holger M., Furlow, J. David, and Bodine, Sue C.

Subjects
DNA binding proteins -- Properties, Hormone receptors -- Properties, Atrophy, Muscular -- Genetic aspects, Muscles -- Genetic aspects, Biological sciences
Abstract

The muscle specific ubiquitin E3 ligase MuRF1 has been implicated as a key regulator of muscle atrophy under a variety of conditions, such as during synthetic glucocorticoid treatment. FOXO class transcription factors have been proposed as important regulators of MuRF1 expression, but its regulation by glucocorticoids is not well understood. The MuRF1 promoter contains a near-perfect palindromic glucocorticoid response element (GRE) 200 base pairs upstream of the transcription start site. The GRE is highly conserved in the mouse, rat, and human genes along with a directly adjacent FOXO binding element (FBE). Transient transfection assays in HepG2 cells and [C.sub.2][C.sub.12] myotubes demonstrate that the MuRF1 promoter is responsive to both the dexamethasone (DEX)-activated ghicocorticoid receptor (GR) and FOXO1, whereas coexpression of GR and FOXO1 leads to a dramatic synergistic increase in reporter gene activity. Mutation of either the GRE or the FBE significantly impairs activation of the MuRF1 promoter. Consistent with these findings, DEX-induced upregulation of MuRF1 is significantly attenuated in mice expressing a homodimerization-deficient GR despite no effect on the degree of muscle loss in these mice vs. their wild-type counterparts. Finally, chromatin immunoprecipitation analysis reveals that both GR and FOXO1 bind to the endogenous MuRF1 promoter in [C.sub.2][C.sub.12] myotubes, and IGF-I inhibition of DEX-induced MuRF1 expression correlates with the loss of FOXO1 binding. These findings present new insights into the role of the GR and FOXO family of transcription factors in the transcriptional regulation of the MuRF1 gene, a direct target of the GR in skeletal muscle. forkhead transcription factor class O; muscle RING finger 1; glucocorticoid receptor

Published
2008

31. A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats

Author

Muller, Nora, van den Brandt, Jens, Odoardi, Francesca, Tischner, Denise, Herath, Judith, Flugel, Alexander, and Reichardt, Holger M.

Subjects
CD8 lymphocytes -- Properties, Antibodies -- Properties, Viral antibodies -- Properties
Abstract

Administration of the CD28 superagonistic antibody JJ316 is an efficient means to treat autoimmune diseases in rats, but the humanized antibody TGN1412 caused devastating side effects in healthy volunteers during a clinical trial. Here we show that JJ316 treatment of rats induced a dramatic redistribution of T lymphocytes from the periphery to the secondary lymphoid organs, resulting in severe T lymphopenia. Live imaging of secondary lymphoid organs revealed that JJ316 administration almost instantaneously (, Introduction Efficient activation of naive T cells by antigen-presenting cells requires the concomitant engagement of the TCR and the costimulatory molecule CD28 (1). These 2 signals result in an upregulation [...]

Published
2008

32. A Quantitative General Population Job Exposure Matrix for Occupational Noise Exposure

Author

IRAS OH Epidemiology Chemical Agents, Stokholm, Zara Ann, Erlandsen, Mogens, Schlünssen, Vivi, Basinas, Ioannis, Bonde, Jens Peter, Peters, Susan, Brandt, Jens, Vestergaard, Jesper Medom, Kolstad, Henrik Albert, IRAS OH Epidemiology Chemical Agents, Stokholm, Zara Ann, Erlandsen, Mogens, Schlünssen, Vivi, Basinas, Ioannis, Bonde, Jens Peter, Peters, Susan, Brandt, Jens, Vestergaard, Jesper Medom, and Kolstad, Henrik Albert

Published
2020

38. Molecular Epidemiology of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Wild, Captive and Laboratory Rats: Effect of Habitat on the Nasal S. aureus Population

Author

Raafat, Dina, primary, Mrochen, Daniel M., additional, Al’Sholui, Fawaz, additional, Heuser, Elisa, additional, Ryll, René, additional, Pritchett-Corning, Kathleen R., additional, Jacob, Jens, additional, Walther, Bernd, additional, Matuschka, Franz-Rainer, additional, Richter, Dania, additional, Westerhüs, Uta, additional, Pikula, Jiri, additional, van den Brandt, Jens, additional, Nicklas, Werner, additional, Monecke, Stefan, additional, Strommenger, Birgit, additional, van Alen, Sarah, additional, Becker, Karsten, additional, Ulrich, Rainer G., additional, and Holtfreter, Silva, additional

Published
2020
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