1,152 results on '"Bradley, Linda"'
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2. Intelligent CALL, Granular Systems and Learner Data: Short Papers from EUROCALL 2022 (30th, Reykjavik, Iceland, August 17-19, 2022)
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Research-publishing.net (France), Arnbjörnsdóttir, Birna, Bédi, Branislav, Bradley, Linda, Friðriksdóttir, Kolbrún, Garðarsdóttir, Hólmfríður, Thouësny, Sylvie, Whelpton, Matthew James, Arnbjörnsdóttir, Birna, Bédi, Branislav, Bradley, Linda, Friðriksdóttir, Kolbrún, Garðarsdóttir, Hólmfríður, Thouësny, Sylvie, Whelpton, Matthew James, and Research-publishing.net (France)
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The 2022 EUROCALL conference was held in Reykjavik on 17-19 August 2022 as a fully online event hosted by the Vigdís Finnbogadóttir Institute for Foreign Languages, the University of Iceland, and the Árni Magnússon Institute for Icelandic Studies. The conference theme was "Intelligent CALL, granular systems and learner data." This theme reflects the newest developments in the field of technology for language learning. Subfields such as natural language processing and machine learning not only enable smoother spoken and written communication between human learners and computers, but also offer ways in which language learning can be tailored to the needs of individual learners. By adding components of automatic speech recognition, text-to-speech systems, automatic feedback mechanisms, and tracking systems monitoring learners' progress and their use of tools, applications are becoming better targeted. All of this is used to optimise the learning experience of individual learners. This volume includes 66 short papers by some of the EUROCALL 2022 presenters and it offers a combination of research studies and theoretical papers reflecting the subthemes of the conference. The articles are ordered alphabetically. [This content is provided in the format of an e-book. Individual papers are indexed in ERIC.]
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- 2022
3. Recent Work on the History and Culture of Religion and Dress
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Bradley, Linda Arthur and Homberger, Torsten
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- 2015
4. Mobile Language Learning Designs and Contexts for Newly Arrived Migrants
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Bradley, Linda and Al-Sabbagh, Khaled Walid
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The mobile phone has become an indispensable device for communication and managing everyday life among newly arrived migrants. Learning a new language is a crucial aspect of integration and professionalization in a foreign country, and the phone is a tool that is also used by migrants also for language learning. The purpose of this study is to investigate how mobile-assisted language learning (MALL) is situated in the context of newly arrived migrants from the Middle East in Sweden as a means to learn a new language. The designs and context of MALL apps used with migrants are explored from a pedagogical perspective and investigated by means of observations and interviews with migrants. The results show that there are difficulties with how MALL apps are used by migrants, as the apps are built on individualised drilling activities with vocabulary training which are neither motivating nor immediately connected to the everyday language learning needs of the migrants. However, gamification aspects built into the apps together with push notifications attract most of the users who do engage with the apps, and these aspects are incentives for building a routine around MALL app usage. The design around the content and functionality plays an important role in how learners make use of mobile applications. [Page range shown on PDF is incorrect. The correct page range is p179-198.]
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- 2022
5. CALL and Professionalisation: Short Papers from EUROCALL 2021 (29th, Online, August 26-27, 2021)
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Research-publishing.net (France), Zoghlami, Naouel, Brudermann, Cédric, Sarré, Cedric, Grosbois, Muriel, Bradley, Linda, Thouësny, Sylvie, Zoghlami, Naouel, Brudermann, Cédric, Sarré, Cedric, Grosbois, Muriel, Bradley, Linda, Thouësny, Sylvie, and Research-publishing.net (France)
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The 2021 EUROCALL conference engaged just under 250 speakers from 40 different countries. Cnam Paris and Sorbonne Université joined forces to host and organise the event despite the challenging context due to the COVID-19 pandemic. Originally programmed to be held on site in the heart of Paris, France, the EUROCALL organising team and executive committee agreed to opt for a blended and then for a fully online conference. The theme of the 2021 EUROCALL conference was "CALL & Professionalisation". This volume, a selection of 54 short papers by some of the EUROCALL 2021 presenters, offers a combination of research studies as well as practical examples fairly representative of the theme of the conference. [This content is provided in the format of an e-book. Individual papers are indexed in ERIC.]
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- 2021
6. Common Threads: A Cultural History of Clothing in American Catholicism by Sally Dwyer-McNulty (review)
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Bradley, Linda Arthur
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- 2015
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7. CALL for Widening Participation: Short Papers from EUROCALL 2020 (28th, Online, August 20-21, 2020)
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Research-publishing.net (France), Frederiksen, Karen-Margrete, Larsen, Sanne, Bradley, Linda, Thouësny, Sylvie, Frederiksen, Karen-Margrete, Larsen, Sanne, Bradley, Linda, Thouësny, Sylvie, and Research-publishing.net (France)
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Despite the COVID-19 pandemic, the EUROCALL society succeeded in holding the 28th EUROCALL conference, EUROCALL2020, on 20-21 August as an online, two-day gathering. The transition process required to make this happen was demanding and insightful for everyone involved, and, in many ways, a logical consequence of the core content and purpose of EUROCALL. Who would be better suited to transform an onsite conference into an online event than EUROCALL? CALL for widening participation was this year's theme. We welcomed contributions from both theoretical and practical perspectives in relation to the many forms and contexts of CALL. We particularly welcomed longitudinal studies or studies that revisited earlier studies. The academic committee accepted 300 abstracts for paper presentations, symposia, workshops, and posters under this theme; 57 short papers are published in this volume. We hope you will enjoy reading this volume, the first one to reflect a one hundred percent online EUROCALL conference/Online Gathering. [This content is provided in the format of an e-book. Individual papers are indexed in ERIC.]
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- 2020
8. Designing Mobile Language Learning with Arabic Speaking Migrants
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Bradley, Linda, Bartram, Lorna, Al-Sabbagh, Khaled Walid, and Algers, Anne
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Learning the language is crucial to be included in a new society. For migrants, the smartphone is a commonly used device for staying connected, which could also be used for language learning purposes. This research concerns mobile literacy with newly arrived Arabic speaking migrants to Sweden and the use of mobile learning as a means for integration. The purpose is to investigate how mobile technology can be designed to support migrants' language learning process. The research concerns technology development where versions of a mobile application (app) are explored from a bottom-up perspective with Arabic speaking migrants. A qualitative method approach is applied, built on design principles focusing on the construction of situated artefacts and evaluation of performance. The results show that intuitive design and engaging content with connections to everyday social situations play important parts in sustaining motivation to engage with an app.
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- 2023
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9. Mobile Literacy among Syrian Refugee Women Teachers
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Bradley, Linda, Bahous, Rima, and Albasa, Ali
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This research project investigates mobile literacy of Syrian refugee women teachers settled in Lebanon and Sweden. Our research provides input into Syrian refugee women teachers' professional aspirations and their connection to informal mobile learning. In both countries, training programs are used for these newly arrived teachers, enabling them to move forward in their careers, where digital and mobile learning play an important part. The purpose is to investigate how Syrian refugee women teachers are blending their teaching profession and vocational training with mobile literacy and digital technology. A qualitative method approach was applied, interviewing 20 refugee women in Lebanon and Sweden, all teachers from Syria. The outcomes show that the teachers are developing their vocational abilities in getting more career-oriented training in their areas of education by means of enhancing their language skills through mobile technology. [For the complete proceedings, see ED600837.]
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- 2019
10. CALL and Complexity: Short Papers from EuroCALL 2019 (27th, Louvain-la-Neuve, Belgium, August 28-31, 2019)
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Research-publishing.net (France), Meunier, Fanny, Van de Vyver, Julie, Bradley, Linda, Thouësny, Sylvie, Meunier, Fanny, Van de Vyver, Julie, Bradley, Linda, Thouësny, Sylvie, and Research-publishing.net (France)
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The 27th European Association of Computer-Assisted Language Learning (EUROCALL) conference was hosted by UCLouvain in Louvain-la-Neuve (Belgium), in collaboration with KU Leuven, from the 28th to the 31st of August 2019. The theme selected for the 2019 EuroCALL conference held in Louvain-la-Neuve was "CALL and complexity." As languages are known to be intrinsically and linguistically complex, as are the many determinants of learning (additional) languages, conference organizers wanted to view complexity as a challenge to be embraced collectively. The 2019 conference paid tribute to providers of Computer Assisted Language Learning (CALL) solutions and recognized the complexity of their task, acknowledged the notion of complexity to ensure the provision of ad hoc CALL solutions, and drew both learners' and teachers' attention to complexity issues so that they can make the most of their learning/teaching experience. The conference program included 189 paper presentations, 4 symposia, 10 workshops, and 46 posters. All of these activities were divided into the following sub-themes in CALL: social inclusion, computer mediated communication and telecollaboration, corpora and language learning, digital bi- and multi-literacies, digital game-based language learning, intelligent CALL, mobile assisted language learning, natural language processing applications, open educational resources and practices, research trends, second language acquisition principles, task complexity, teacher education and professional development, the complexity, accuracy, and fluency framework, and virtual reality and gamification.
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- 2019
11. Future-Proof CALL: Language Learning as Exploration and Encounters. Short Papers from EUROCALL 2018 (26th, Jyväskylä, Finland, 2018)
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Research-publishing.net (France), Taalas, Peppi, Jalkanen, Juha, Bradley, Linda, Thouësny, Sylvie, Taalas, Peppi, Jalkanen, Juha, Bradley, Linda, Thouësny, Sylvie, and Research-publishing.net (France)
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The 26th European Association of Computer-Assisted Language Learning (EUROCALL) conference was organised by the University of Jyväskylä (JYU) Language Campus and specifically the Language Centre, in Jyväskylä, Finland. The theme of this year's conference was "Future-proof CALL: language learning as exploration and encounters," which reflects an attempt to envision language teaching and learning futures in a changing world. What brought researchers together this year are shared concerns in relation to the sustainability of language learning and teaching in technology-rich contexts that are marked by ever-increasing complexity. 184 submissions were accepted to be presented as workshops, symposia, individual oral presentations, or posters. The oral presentations were categorised as research, research and development, reflective practice papers, along with presentations on European projects. The collection of short papers in this volume is a very thorough view into the conference proper exhibiting the complexity and novelty of the field of CALL. There are exciting new openings and a more profound exploration of theoretical underpinnings of the contemporary issues in teaching and learning, cross-cultural communication, mobile learning and the like. (Individual papers contain references.)
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- 2018
12. Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities
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Lu, Zhen, Bae, Eun-Ah, Verginadis, Ioannis I., Zhang, Hongru, Cho, Christina, McBrearty, Noreen, George, Subin S., Diehl, J. Alan, Koumenis, Constantinos, Bradley, Linda M., and Fuchs, Serge Y.
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- 2023
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13. Comparing endometrial biopsy results with hysteroscopic pathology in women presenting with abnormal and postmenopausal uterine bleeding
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Ferrando, Cecile A., Lintel, M. Kate, and Bradley, Linda D.
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- 2023
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14. FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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Shen, Jia Z, Qiu, Zhixin, Wu, Qiulian, Finlay, Darren, Garcia, Guillermina, Sun, Dahui, Rantala, Juha, Barshop, William, Hope, Jennifer L, Gimple, Ryan C, Sangfelt, Olle, Bradley, Linda M, Wohlschlegel, James, Rich, Jeremy N, and Spruck, Charles
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Cancer ,Immunotherapy ,Human Genome ,Genetics ,2.1 Biological and endogenous factors ,1.1 Normal biological development and functioning ,Adult ,Cell Line ,Tumor ,Cell Proliferation ,Cell Survival ,DNA Breaks ,Double-Stranded ,DNA Replication ,Drug Resistance ,Neoplasm ,F-Box Proteins ,Female ,Gene Expression Regulation ,Neoplastic ,Histones ,Humans ,Immune Checkpoint Inhibitors ,Immunity ,Interferons ,Lysine ,Male ,Methylation ,Middle Aged ,Neoplasm Proteins ,Neoplasms ,Nucleosomes ,Repetitive Sequences ,Nucleic Acid ,Signal Transduction ,Transcription ,Genetic ,Treatment Outcome ,FBXO44 ,H3K9me3 ,SUV39H1 ,immunotherapy ,repetitive elements ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology ,Biological sciences ,Biomedical and clinical sciences - Abstract
Repetitive elements (REs) compose ∼50% of the human genome and are normally transcriptionally silenced, although the mechanism has remained elusive. Through an RNAi screen, we identified FBXO44 as an essential repressor of REs in cancer cells. FBXO44 bound H3K9me3-modified nucleosomes at the replication fork and recruited SUV39H1, CRL4, and Mi-2/NuRD to transcriptionally silence REs post-DNA replication. FBXO44/SUV39H1 inhibition reactivated REs, leading to DNA replication stress and stimulation of MAVS/STING antiviral pathways and interferon (IFN) signaling in cancer cells to promote decreased tumorigenicity, increased immunogenicity, and enhanced immunotherapy response. FBXO44 expression inversely correlated with replication stress, antiviral pathways, IFN signaling, and cytotoxic T cell infiltration in human cancers, while a FBXO44-immune gene signature correlated with improved immunotherapy response in cancer patients. FBXO44/SUV39H1 were dispensable in normal cells. Collectively, FBXO44/SUV39H1 are crucial repressors of RE transcription, and their inhibition selectively induces DNA replication stress and viral mimicry in cancer cells.
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- 2021
15. Professional Development of Syrian Refugee Women: Proceeding with a Career within Education
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Bradley, Linda, Bahous, Rima, and Albasha, Ali
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This research investigates professional development with Syrian refugee women teachers settled in Lebanon and Sweden. Both countries offer professional training programmes for migrant teachers, enabling them to proceed with their careers. The purpose is to investigate how moving to a new country calls for an opportunity to engage in practice development and the role digital literacy plays in the refugees' lives. We conducted interviews with twenty women in Lebanon and Sweden. The outcomes show that engaging in further career development is empowering and beneficial for strengthening and developing teaching and learning skills, and mobile literacy plays a role in overcoming the language barrier.
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- 2022
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16. The Impact of Fertility Goals on Long-term Quality of Life in Reproductive-aged Women Who Underwent Myomectomy versus Hysterectomy for Uterine Fibroids
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Frisch, Emily H., Mitchell, Jameson, Yao, Meng, Llarena, Natalia, Omosigho, Ukpebo R., DeAngelo, Lydia, Arakelian, Miranda, Bradley, Linda, and Falcone, Tommaso
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- 2023
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17. Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth
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Li, Yan, Elmén, Lisa, Segota, Igor, Xian, Yibo, Tinoco, Roberto, Feng, Yongmei, Fujita, Yu, Muñoz, Rafael R Segura, Schmaltz, Robert, Bradley, Linda M, Ramer-Tait, Amanda, Zarecki, Raphy, Long, Tao, Peterson, Scott N, and Ronai, Ze’ev A
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Microbiology ,Biological Sciences ,Nutrition ,Cancer ,Digestive Diseases ,Colo-Rectal Cancer ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Good Health and Well Being ,Animals ,Gastrointestinal Microbiome ,Inulin ,Melanoma ,Mice ,Mucins ,Prebiotics ,MEK inhibitor ,anti-tumor immunity ,colon cancer ,gut microbiota ,inulin ,melanoma ,mucin ,prebiotics ,therapy resistance ,Biochemistry and Cell Biology ,Medical Physiology ,Biological sciences - Abstract
Growing evidence supports the importance of gut microbiota in the control of tumor growth and response to therapy. Here, we select prebiotics that can enrich bacterial taxa that promote anti-tumor immunity. Addition of the prebiotics inulin or mucin to the diet of C57BL/6 mice induces anti-tumor immune responses and inhibition of BRAF mutant melanoma growth in a subcutaneously implanted syngeneic mouse model. Mucin fails to inhibit tumor growth in germ-free mice, indicating that the gut microbiota is required for the activation of the anti-tumor immune response. Inulin and mucin drive distinct changes in the microbiota, as inulin, but not mucin, limits tumor growth in syngeneic mouse models of colon cancer and NRAS mutant melanoma and enhances the efficacy of a MEK inhibitor against melanoma while delaying the emergence of drug resistance. We highlight the importance of gut microbiota in anti-tumor immunity and the potential therapeutic role for prebiotics in this process.
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- 2020
18. Siah2 control of T-regulatory cells limits anti-tumor immunity.
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Scortegagna, Marzia, Hockemeyer, Kathryn, Dolgalev, Igor, Poźniak, Joanna, Rambow, Florian, Li, Yan, Feng, Yongmei, Tinoco, Roberto, Otero, Dennis C, Zhang, Tongwu, Brown, Kevin, Bosenberg, Marcus, Bradley, Linda M, Marine, Jean-Christophe, Aifantis, Ioannis, and Ronai, Ze'ev A
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Animals ,Mice ,Knockout ,Humans ,Mice ,Melanoma ,Ubiquitin-Protein Ligases ,Nuclear Proteins ,T-Lymphocytes ,Regulatory ,Chemokine CCL17 ,Chemokine CCL22 ,Forkhead Box Protein O3 ,Knockout ,T-Lymphocytes ,Regulatory - Abstract
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice. Growth-inhibited tumors exhibit increased numbers of intra-tumoral activated T cells and decreased expression of Ccl17, Ccl22, and Foxp3. Marked reduction in Treg proliferation and tumor infiltration coincide with G1 arrest in tumor infiltrated Siah2-/- Tregs in vivo or following T cell stimulation in culture, attributed to elevated expression of the cyclin-dependent kinase inhibitor p27, a Siah2 substrate. Growth of anti-PD-1 therapy resistant melanoma is effectively inhibited in Siah2-/- mice subjected to PD-1 blockade, indicating synergy between PD-1 blockade and Siah2 loss. Low SIAH2 and FOXP3 expression is identified in immune responsive human melanoma tumors. Overall, Siah2 regulation of Treg recruitment and cell cycle progression effectively controls melanoma development and Siah2 loss in the host sensitizes melanoma to anti-PD-1 therapy.
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- 2020
19. PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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Hope, Jennifer L., Otero, Dennis C., Bae, Eun-Ah, Stairiker, Christopher J., Palete, Ashley B., Faso, Hannah A., Lin, Michelle, Henriquez, Monique L., Roy, Sreeja, Seo, Hyungseok, Lei, Xue, Wang, Eric S., Chow, Savio, Tinoco, Roberto, Daniels, Gregory A., Yip, Kevin, Campos, Alexandre Rosa, Yin, Jun, Adams, Peter D., Rao, Anjana, and Bradley, Linda M.
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- 2023
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20. Refugees’ aspirations, attitudes, and experiences of higher education and professional life in Sweden
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Olsson, Fredrik, Bradley, Linda, and Abughalioun, Maisaa
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- 2023
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21. Mobile Resources for Integration: How Availability Meets the Needs of Newly Arrived Arabic-Speaking Migrants in Sweden
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Lindström, Nataliya Berbyuk, Hashemi, Sylvana Sofkova, Bartram, Lorna, and Bradley, Linda
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The paper reports on the availability and use of mobile resources by newly arrived Arabic migrants in Sweden, and how the resources meet migrants' integration needs. Analysis of websites and applications (hereafter apps) in combination with focus group interviews is used. Results show that though a variety of resources are available, translation and vocabulary apps are primarily used. Possible reasons are lack of connection in language training resources to migrants' immediate needs such as employment and education, accommodation, contact with locals and societal information (Ager & Strang, 2008). Cultural differences might be influential for Arabic-speakers' low use of chat apps for communication with locals. [For the complete volume, see ED578177.]
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- 2017
22. CALL in a Climate of Change: Adapting to Turbulent Global Conditions. Short Papers from EUROCALL 2017 (25th, Southampton, United Kingdom, August 23-26, 2017)
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Research-publishing.net (France), Borthwick, Kate, Bradley, Linda, and Thouësny, Sylvie
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The 25th European Association of Computer-Assisted Language Learning (EUROCALL) conference was hosted by Modern Languages and Linguistics at the University of Southampton, in the United Kingdom, from the 23rd to the 26th of August 2017. The theme of the conference was "CALL in a climate of change." The theme encompassed the notion of how practice and research in CALL is responding to shifting global circumstances which impact education, including developments arising from economic, political, or environmental change. It cut across areas including considerations for teacher training, competitive educational models, open education, new models for blended learning, collaboration, mobile learning, creative and innovative pedagogy, data analytics, students' needs and sustainability--and crucially, it looked to the future with optimism. The programme was packed with over 200 sessions related to this topic, and it included a large number of workshops, pecha kucha, posters, and symposia. This volume offers a snapshot of this dynamic landscape and contains 60 of the papers presented. This volume reflects the wide variety of topics featured at the conference and the high quality of contributions. (Individual papers contain references.)
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- 2017
23. Students' Collaborative Peer Reviewing in an Online Writing Environment
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Bradley, Linda and Thouësny, Sylvie
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Peer review is applied as a powerful tool to enhance student collaboration online writing. The purpose of this paper is to analyse learners' mechanisms of peer reviewing in the nature of student interventions and interactions in written online peer reviewing and how categorization of student comments can be used as a means for analysing student peer reviewing. The study is an in-depth investigation of computer science students participating in a technical writing course, using Google Drive as their joint work space. While writing their group text, the students were participating in peer reviewing work. Results show combining analysis models provide a better understanding of the implication of commenting in both scrutinizing the progressive scale of assistance, as well as area, nature, and type of commenting, together with what themes evolve. Further, taking turns providing feedback is an enriching activity.
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- 2017
24. Integration and Language Learning of Newly Arrived Migrants Using Mobile Technology
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Bradley, Linda, Lindström, Nataliya Berbyuk, and Hashemi, Sylvana Sofkova
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The purpose of this study is to investigate the mobile activities newly arrived migrants are engaged in when learning the Swedish language and about Swedish culture and society. Further, the study also explores the use of a mobile application (app) provided to the newly arrived migrants to use for pronunciation practice. The study involved 38 newly arrived Arabic speaking migrants participating in an introduction program of the Swedish language and Swedish culture provided by the Swedish government. The participants were divided into two groups: a control group who received training according to the traditional introduction programme and an experimental group who used a mobile app for pronunciation training as a complement to the programme. We applied a combination of qualitative and quantitative methods for data collection and analysis. The participants were interviewed about their use of mobile phones as well as recorded in a number of activities inside and outside the classroom to compare their language evolvement. In addition, surveys, logging of weekly mobile activities and observations were performed. The results show that the participants used a wide range of different mobile tools, both inside and outside the classroom. However, they used the mobiles mostly for communication with their family and friends rather than for communication with Swedes and learning Swedish. Further, compared to the control group, the experimental group showed an improved speech tempo and self-confidence in speaking. The study thus indicates that focused linguistic training with a pronunciation app is useful for developing spoken language skills, which can lead to improved integration. The participants expressed need and interest in having more mobile apps for both language and culture training.
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- 2017
25. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice.
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Li, Yan, Tinoco, Roberto, Elmén, Lisa, Segota, Igor, Xian, Yibo, Fujita, Yu, Sahu, Avinash, Zarecki, Raphy, Marie, Kerrie, Feng, Yongmei, Khateb, Ali, Frederick, Dennie T, Ashkenazi, Shiri K, Kim, Hyungsoo, Perez, Eva Guijarro, Day, Chi-Ping, Segura Muñoz, Rafael S, Schmaltz, Robert, Yooseph, Shibu, Tam, Miguel A, Zhang, Tongwu, Avitan-Hersh, Emily, Tzur, Lihi, Roizman, Shoshana, Boyango, Ilanit, Bar-Sela, Gil, Orian, Amir, Kaufman, Randal J, Bosenberg, Marcus, Goding, Colin R, Baaten, Bas, Levesque, Mitchell P, Dummer, Reinhard, Brown, Kevin, Merlino, Glenn, Ruppin, Eytan, Flaherty, Keith, Ramer-Tait, Amanda, Long, Tao, Peterson, Scott N, Bradley, Linda M, and Ronai, Ze'ev A
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Intestines ,Animals ,Mice ,Inbred C57BL ,Mice ,Knockout ,Humans ,Mice ,Bacteria ,Melanoma ,Ubiquitin-Protein Ligases ,Antimicrobial Cationic Peptides ,Membrane Proteins ,Cell Proliferation ,Unfolded Protein Response ,Gastrointestinal Microbiome ,Inbred C57BL ,Knockout - Abstract
Accumulating evidence points to an important role for the gut microbiome in anti-tumor immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, limiting tumor expansion. Mice lacking the ubiquitin ligase RNF5 exhibit attenuated activation of the unfolded protein response (UPR) components, which coincides with increased expression of inflammasome components, recruitment and activation of dendritic cells and reduced expression of antimicrobial peptides in intestinal epithelial cells. Reduced UPR expression is also seen in murine and human melanoma tumor specimens that responded to immune checkpoint therapy. Co-housing of Rnf5-/- and WT mice abolishes the anti-tumor immunity and tumor inhibition phenotype, whereas transfer of 11 bacterial strains, including B. rodentium, enriched in Rnf5-/- mice, establishes anti-tumor immunity and restricts melanoma growth in germ-free WT mice. Altered UPR signaling, exemplified in Rnf5-/- mice, coincides with altered gut microbiota composition and anti-tumor immunity to control melanoma growth.
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- 2019
26. Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids: two randomised, placebo-controlled, phase 3 trials
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Donnez, Jacques, Taylor, Hugh S, Stewart, Elizabeth A, Bradley, Linda, Marsh, Erica, Archer, David, Al-Hendy, Ayman, Petraglia, Felice, Watts, Nelson, Gotteland, Jean-Pierre, Bestel, Elke, Terrill, Paul, Loumaye, Ernest, Humberstone, Andrew, and Garner, Elizabeth
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- 2022
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27. A Call-to-Action for Clinicians to Implement Evidence-Based Best Practices When Caring for Women with Uterine Fibroids
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Leyland, Nicholas, Leonardi, Mathew, Murji, Ally, Singh, Sukhbir S., Al-Hendy, Ayman, and Bradley, Linda
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- 2022
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28. Resolving the conflicts around Par2 opposing roles in regeneration by comparing immune-mediated and toxic-induced injuries
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Reches, Gal, Blondheim Shraga, Netta R., Carrette, Florent, Malka, Assaf, Saleev, Natalia, Gubbay, Yehuda, Ertracht, Offir, Haviv, Izhak, Bradley, Linda M., Levine, Fred, and Piran, Ron
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- 2022
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29. International Consensus Statement for Recommended Terminology Describing Hysteroscopic Procedures
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Carugno, Jose, Grimbizis, Grigoris, Franchini, Mario, Alonso, Luis, Bradley, Linda, Campo, Rudi, Catena, Ursula, Carlo, De Angelis, Attilio, Di Spiezio Sardo, Martin, Farrugia, Haimovich, Sergio, Isaacson, Keith, Moawad, Nash, Saridogan, Ertan, and Clark, T. Justin
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- 2022
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30. CALL Communities & Culture: Short Papers from EUROCALL 2016 (23rd, Limassol, Cyprus, August 24-27, 2016)
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Research-publishing.net (France), Papadima-Sophocleous, Salomi, Bradley, Linda, and Thouësny, Sylvie
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The 23rd EUROCALL conference was held in Cyprus from the 24th to the 27th of August 2016. The theme of the conference this year was "CALL Communities and Culture." It offered a unique opportunity to hear from real-world CALL practitioners on how they practice CALL in their communities, and how the CALL culture has developed in local and global contexts. Short papers from the conference are presented in this volume: (1) The impact of EFL teachers' mediation in wiki-mediated collaborative writing activities on student-student collaboration (Maha Alghasab); (2) Towards the development of a comprehensive pedagogical framework for pronunciation training based on adaptive automatic speech recognition systems (Saandia Ali); (3) Digital literacy and sustainability--a field study in EFL teacher development (Christopher Allen and Jan Berggren); (4) Self-evaluation using iPads in EFL teaching practice (Christopher Allen, Stella K. Hadjistassou, and David Richardson); (5) Amateur online interculturalism in foreign language education (Antonie Alm); (6) Teaching Turkish in low tech contexts: opportunities and challenges (Katerina Antoniou, Evelyn Mbah, and Antigoni Parmaxi); (7) Learning Icelandic language and culture in virtual Reykjavic: starting to talk (Branislav Bédi, Birna Arnbjörnsdóttir, Hannes Högni Vilhjálmsson, Hafdís Erla Helgadóttir, Stefán Ólafsson, and Elías Björgvinsson); (8) Investigating student choices in performing higher-level comprehension tasks using TED (Francesca Bianchi and Ivana Marenzi); (9) An evaluation of text-to-speech synthesizers in the foreign language classroom: learners' perceptions (Tiago Bione, Jennica Grimshaw, and Walcir Cardoso); (10) Quantifying CALL: significance, effect size and variation (Alex Boulton; (11) The contribution of CALL to advanced-level foreign/second language instruction (Jack Burston and Kelly Arispe); (12) Using instructional technology to integrate CEFR "can do" performance objectives into an advanced-level language course (Jack Burston, Androulla Athanasiou, and Maro Neophytou-Yiokari); (13) Exploiting behaviorist and communicative action-based methodologies in CALL applications for the teaching of pronunciation in French as a foreign language (Jack Burston, Olga Georgiadou, and Monique Monville-Burston); (14) Mobile assisted language learning of less commonly taught languages: learning in an incidental and situated way through an app (Cristiana Cervini, Olga Solovova, Annukka Jakkula, and Karolina Ruta); (15) Using object-based activities and an online inquiry platform to support learners' engagement with their heritage language and culture (Koula Charitonos, Marina Charalampidi, and Eileen Scanlon); (16) Urban explorations for language learning: a gamified approach to teaching Italian in a university context (Koula Charitonos, Luca Morini, Sylvester Arnab, Tiziana Cervi-Wilson, and Billy Brick); (17) Communicate to learn, learn to communicate: a study of engineering students' communication strategies in a mobile-based learning environment (Li Cheng and Zhihong Lu); (18) Using a dialogue system based on dialogue maps for computer assisted second language learning (Sung-Kwon Choi, Oh-Woog Kwon, Young-Kil Kim, and Yunkeun Lee); (19) Students' attitudes and motivation towards technology in a Turkish language classroom (Pelekani Chryso); (20) Vlogging: a new channel for language learning and intercultural exchanges (Christelle Combe and Tatiana Codreanu); (21) Japanese university students' self-assessment and digital literacy test results (Travis Cote and Brett Milliner); (22) Digital story (re)telling using graded readers and smartphones (Kazumichi Enokida); (23) HR4EU--a web portal for e-learning of Croatian (Matea Filko, Daša Farkaš, and Diana Hriberski); (24) Synchronous tandem language learning in a MOOC context: a study on task design and learner performance (Marta Fondo Garcia and Christine Appel); (25) What students think and what they actually do in a mobile assisted language learning context: new insights for self-directed language learning in higher education (Gustavo Garcia Botero and Frederik Questier); (26) An Audio-Lexicon Spanish-Nahuatl: using technology to promote and disseminate a native Mexican language (Rafael García-Mencía, Aurelio López-López, and Angélica Muñoz Meléndez; (27) The use of interactive whiteboards: enhancing the nature of teaching young language learners (Christina Nicole Giannikas); (28) A pre-mobility eTandem project for incoming international students at the University of Padua (Lisa Griggio and Edit Rózsavölgyi); (29) Can a "shouting" digital game help learners develop oral fluency in a second language? (Jennica Grimshaw, Walcir Cardoso, and David Waddington); (30) Feedback visualization in a grammar-based e-learning system for German: a preliminary user evaluation with the COMPASS system (Karin Harbusch and Annette Hausdörfer); (31) The multimodality of lexical explanation sequences during videoconferenced pedagogical interaction (Benjamin Holt); (32) Automatic dialogue scoring for a second language learning system (Jin-Xia Huang, Kyung-Soon Lee, Oh-Woog Kwon, and Young-Kil Kim); (33) Effects of task-based videoconferencing on speaking performance and overall proficiency (Atsushi Iino, Yukiko Yabuta, and Yoichi Nakamura); (34) Tellecollaborative games for youngsters: impact on motivation (Kristi Jauregi); (35) The Exercise: an Exercise generator tool for the SOURCe project (Kryni Kakoyianni-Doa, Eleni Tziafa, and Athanasios Naskos); (36) Students' perceptions of online apprenticeship projects at a university (Hisayo Kikuchi); (37) The effects of multimodality through storytelling using various movie clips (SoHee Kim); (38) Collaboration through blogging: the development of writing and speaking skills in ESP courses (Angela Kleanthous and Walcir Cardoso); (39) Cultivating a community of learners in a distance learning postgraduate course for language professionals (Angelos Konstantinidis and Cecilia Goria); (40) Task-oriented spoken dialog system for second-language learning (Oh-Woog Kwon, Young-Kil Kim, and Yunkeun Lee); (41) Promoting multilingual communicative competence through multimodal academic learning situations (Anna Kyppö and Teija Natri); (42) Teacher professional learning: developing with the aid of technology (Marianna Kyprianou and Eleni Nikiforou); (43) Quizlet: what the students think--a qualitative data analysis (Bruce Lander); (44) "Just facebook me": a study on the integration of Facebook into a German language curriculum (Vera Leier and Una Cunningham); (45) A survey on Chinese students' online English language learning experience through synchronous web conferencing classrooms (Chenxi Li); (46) Identifying and activating receptive vocabulary by an online vocabulary survey and an online writing task (Ivy Chuhui Lin and Goh Kawai); (47) Exploring learners' perceptions of the use of digital letter games for language learning: the case of Magic Word (Mathieu Loiseau, Cristiana Cervini, Andrea Ceccherelli, Monica Masperi, Paola Salomoni, Marco Roccetti, Antonella Valva, and Francesca Bianco); (48) Game of Words: prototype of a digital game focusing on oral production (and comprehension) through asynchronous interaction (Mathieu Loiseau, Racha Hallal, Pauline Ballot, and Ada Gazidedja); (49) PETALL in action: latest developments and future directions of the EU-funded Pan-European Task Activities for Language Learning (António Lopes); (50) Exploring EFL learners' lexical application in AWE-based writing (Zhihong Lu and Zhenxiao Li); (51) Mobile-assisted language learning and language learner autonomy (Paul A. Lyddon); (52) YELL/TELL: online community platform for teacher professional development (Ivana Marenzi, Maria Bortoluzzi, and Rishita Kalyani); (53) Leveraging automatic speech recognition errors to detect challenging speech segments in TED talks (Maryam Sadat Mirzaei, Kourosh Meshgi, and Tatsuya Kawahara); (54) Investigating the affective learning in a 3D virtual learning environment: the case study of the Chatterdale mystery (Judith Molka-Danielsen, Stella Hadjistassou, and Gerhilde Messl-Egghart); (55) Are commercial "personal robots" ready for language learning? Focus on second language speech (Souheila Moussalli and Walcir Cardoso); (56) The Digichaint interactive game as a virtual learning environment for Irish (Neasa Ni Chiaráin and Ailbhe Ní Chasaide); (57) Mingling students' cognitive abilities and learning strategies to transform CALL (Efi Nisiforou and Antigoni Parmaxi); (58) Taking English outside of the classroom through social networking: reflections on a two-year project (Louise Ohashi); (59) Does the usage of an online EFL workbook conform to Benford's law? (Mikolaj Olszewski, Kacper Lodzikowski, Jan Zwolinski, Rasil Warnakulasooriya, and Adam Black); (60) Implications on pedagogy as a result of adopted CALL practices (James W. Pagel and Stephen G. Lambacher); (61) Exploring the benefits and disadvantages of introducing synchronous to asynchronous online technologies to facilitate flexibility in learning (Salomi Papadima-Sophocleous and Fernando Loizides); (62) A CALL for evolving teacher education through 3D microteaching (Giouli Pappa and Salomi Papadima-Sophocleous); (63) Physicality and language learning (Jaeuk Park, Paul Seedhouse, Rob Comber, and Jieun Kiaer); (64) Designing strategies for an efficient language MOOC (Maria Perifanou); (65) Worldwide state of language MOOCs (Maria Perifanou); (66) A Spanish-Finnish telecollaboration: extending intercultural competence via videoconferencing (Pasi Puranen and Ruby Vurdien); (67) Developing oral interaction skills with a digital information gap activity game (Avery Rueb, Walcir Cardoso, and Jennica Grimshaw); (68) Using WebQuests as idea banks for fostering autonomy in online language courses (Shirin Sadaghian and S. Susan Marandi); (69) Integrating mobile technologies into very young second language learners' curriculum (Gulnara Sadykova, Gulnara Gimaletdinova, Liliia Khalitova, and Albina Kayumova); (70) Investigating commercially available technology for language learners in higher education within the high functioning disability spectrum (Georgia Savvidou and Fernando Loizides); (71) Learning languages in 3D worlds with Machinima (Christel Schneider); (72) What are more effective in English classrooms: textbooks or podcasts? (Jaime Selwood, Joe Lauer, and Kazumichi Enokida); (73) Mind the gap: task design and technology in novice language teachers' practice (Tom F. H. Smits, Margret Oberhofer, and Jozef Colpaert); (74) Language immersion in the self-study mode e-course (Olga Sobolev); (75) Aligning out-of-class material with curriculum: tagging grammar in a mobile music application (Ross Sundberg and Walcir Cardoso); (76) Meeting the technology standards for language teachers (Cornelia Tschichold); (77) Mobile-assisted language learning community and culture in French-speaking Belgium: the teachers' perspective (Julie Van de Vyver); (78) Classification of Swedish learner essays by CEFR levels (Elena Volodina, Ildikó Pilán, and David Alfter); (79) Mobile assisted language learning and mnemonic mapping--the loci method revisited (Ikumi Waragai, Marco Raindl, Tatsuya Ohta, and Kosuke Miyasaka); (80) CALL and less commonly taught languages--still a way to go (Monica Ward); (81) Demystifying pronunciation with animation (Monica Ward); (82) The effects of utilizing corpus resources to correct collocation errors in L2 writing--Students' performance, corpus use and perceptions (Yi-ju Wu); (83) A social constructionist approach to teaching and learning vocabulary for Italian for academic purposes (Eftychia Xerou, Salomi Papadima-Sophocleous, and Antigoni Parmaxi); (84) Flip-J: development of the system for flipped jigsaw supported language learning (Masanori Yamada, Yoshiko Goda, Kojiro Hata, Hideya Matsukawa, and Seisuke Yasunami); and (85) "Check your Smile", prototype of a collaborative LSP website for technical vocabulary (Nadia Yassine-Diab, Charlotte Alazard-Guiu, Mathieu Loiseau, Laurent Sorin, and Charlotte Orliac). An author index is included. (Individual papers contain references.)
- Published
- 2016
31. Pedagogical Framing of OER--The Case of Language Teaching
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Bradley, Linda and Vigmo, Sylvi
- Abstract
This study investigates what characterises teachers' pedagogical design of OER [Open Educational Resources], and potential affordances and constraints in pedagogical design in an open education practice, when contributing to a Swedish repository Lektion.se. The teachers' framing of the OER shared on the repository included the analyses of a delimited number of OER for learning Swedish. The analytical work with analysing what characterised the OER, was followed up with teacher interviews to explore teachers' incentives for sharing. The OER selected for analysis were investigated linked to the features given in the repository, to identify what distinguished different categories of OER when framed by the teachers. The OER displayed a continuum of ways of framing an activity, though the majority was represented by low levels of description, which afforded less guidance. The teachers expressed a positive attitude towards sharing. The findings suggest that OER need to be defined and supported by web features to enable going beyond reuse.
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- 2016
32. Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis
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Fujita, Yu, Khateb, Ali, Li, Yan, Tinoco, Roberto, Zhang, Tongwu, Bar-Yoseph, Haggai, Tam, Miguel A, Chowers, Yehuda, Sabo, Edmond, Gerassy-Vainberg, Shiran, Starosvetsky, Elina, James, Brian, Brown, Kevin, Shen-Orr, Shai S, Bradley, Linda M, Tessier, Philippe A, and Ronai, Ze’ev A
- Subjects
Biological Sciences ,Inflammatory Bowel Disease ,Crohn's Disease ,Digestive Diseases ,Autoimmune Disease ,Aetiology ,2.1 Biological and endogenous factors ,Underpinning research ,1.1 Normal biological development and functioning ,Oral and gastrointestinal ,Animals ,Antibodies ,Neutralizing ,CD4-Positive T-Lymphocytes ,Calgranulin A ,Cell Line ,Cells ,Cultured ,Colitis ,Ulcerative ,Enterocytes ,HEK293 Cells ,Humans ,Membrane Proteins ,Mice ,Mice ,Inbred C57BL ,Protein Stability ,Ubiquitin-Protein Ligases ,IBD ,RNF5 ,S100A8 ,acute colitis ,intestinal epithelial cells ,intestinal inflammation ,ubiquitin ligase ,Biochemistry and Cell Biology ,Medical Physiology ,Biological sciences - Abstract
Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase RNF5 in IBD. Intestinal epithelial cells (IECs) express a high level of RNF5, while the colon of Rnf5-/- mice exhibits activated dendritic cells and intrinsic inflammation. Rnf5-/- mice exhibit severe acute colitis following dextran sodium sulfate (DSS) treatment. S100A8 is identified as an RNF5 substrate, resulting in S100A8 ubiquitination and proteasomal-dependent degradation that is attenuated upon inflammatory stimuli. Loss of RNF5 from IECs leads to enhanced S100A8 secretion, which induces mucosal CD4+ T cells, resulting in Th1 pro-inflammatory responses. Administration of S100A8-neutralizing antibodies to DSS-treated Rnf5-/- mice attenuates acute colitis development and increases survival. An inverse correlation between RNF5 and S100A8 protein expression in IECs of IBD patients coincides with disease severity. Collectively, RNF5-mediated regulation of S100A8 stability in IECs is required for the maintenance of intestinal homeostasis.
- Published
- 2018
33. Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis
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Borlido, Joana, Sakuma, Stephen, Raices, Marcela, Carrette, Florent, Tinoco, Roberto, Bradley, Linda M, and D’Angelo, Maximiliano A
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Immunology ,1.1 Normal biological development and functioning ,Aetiology ,2.1 Biological and endogenous factors ,Underpinning research ,Animals ,CD4-Positive T-Lymphocytes ,Homeostasis ,Mice ,Mice ,Inbred C57BL ,Mice ,Transgenic ,Nuclear Pore ,Nuclear Pore Complex Proteins ,Receptors ,Antigen ,T-Cell ,Signal Transduction ,Biochemistry and cell biology - Abstract
Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4+ T cells. Nup210-deficient CD4+ T lymphocytes develop normally but fail to survive in the periphery. The decreased survival results from both an impaired ability to transmit tonic T cell receptor (TCR) signals and increased levels of Fas, which sensitize Nup210-/- naïve CD4+ T cells to Fas-mediated cell death. Mechanistically, Nup210 regulates these processes by modulating the expression of Cav2 (encoding Caveolin-2) and Jun at the nuclear periphery. Whereas the TCR-dependent and CD4+ T cell-specific upregulation of Cav2 is critical for proximal TCR signaling, cJun expression is required for STAT3-dependent repression of Fas. Our results uncover an unexpected role for Nup210 as a cell-intrinsic regulator of TCR signaling and T cell homeostasis and expose NPCs as key players in the adaptive immune system.
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- 2018
34. Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells
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Tinoco, Roberto, Carrette, Florent, Henriquez, Monique L, Fujita, Yu, and Bradley, Linda M
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Pneumonia & Influenza ,Prevention ,Infectious Diseases ,Biodefense ,Vaccine Related ,Influenza ,Emerging Infectious Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Infection ,Animals ,Biosynthetic Pathways ,CD4-Positive T-Lymphocytes ,Fucosyltransferases ,Immunologic Memory ,Lung ,Mice ,Mice ,Inbred C57BL ,Orthomyxoviridae ,Orthomyxoviridae Infections ,Immunology - Abstract
T cells mediating influenza viral control are instructed in lymphoid and nonlymphoid tissues to differentiate into memory T cells that confer protective immunity. The mechanisms by which influenza virus-specific memory CD4+ T cells arise have been attributed to changes in transcription factors, cytokines and cytokine receptors, and metabolic programming. The molecules involved in these biosynthetic pathways, including proteins and lipids, are modified to varying degrees of glycosylation, fucosylation, sialation, and sulfation, which can alter their function. It is currently unknown how the glycome enzymatic machinery regulates CD4+ T cell effector and memory differentiation. In a murine model of influenza virus infection, we found that fucosyltransferase enzymatic activity was induced in effector and memory CD4+ T cells. Using CD4+ T cells deficient in the Fut4/7 enzymes that are expressed only in hematopoietic cells, we found decreased frequencies of effector cells with reduced expression of T-bet and NKG2A/C/E in the lungs during primary infection. Furthermore, Fut4/7-/- effector CD4+ T cells had reduced survival with no difference in proliferation or capacity for effector function. Although Fut4/7-/- CD4+ T cells seeded the memory pool after primary infection, they failed to form tissue-resident cells, were dysfunctional, and were unable to re-expand after secondary infection. Our findings highlight an important regulatory axis mediated by cell-intrinsic fucosyltransferase activity in CD4+ T cell effectors that ensure the development of functional memory CD4+ T cells.
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- 2018
35. Critical CALL: Proceedings of the 2015 EUROCALL Conference (22nd, Padova, Italy, August 26-29, 2015)
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Research-publishing.net (France), Helm, Francesca, Bradley, Linda, Guarda, Marta, and Thouësny, Sylvie
- Abstract
The 22nd EUROCALL conference was held at the University of Padova from the 26th to the 29th of August 2015, the first time that EUROCALL has been held in Italy. The event was organized in collaboration with the University Language Centre and the support of the Department of Political Science, Law and International Studies. Over 300 delegates travelled from over 37 different countries to attend. The theme of the conference this year was Critical CALL, drawing inspiration from the work carried out in the broader field of Critical Applied Linguistics. The term "critical" has many possible interpretations, and as Pennycook (2001) outlines, has many concerns. It was from these that the conference theme was decided, in particular the notion that assumptions that lie at the basis of a field's praxis should be questioned, ideas that have become "naturalized" and are not called into question. Another concern of Critical Applied Linguistics is the relationship between the macro and the micro, an engagement with issues of power and inequality and an understanding of how classrooms and conversations are related to broader social, cultural and political relations. Over 200 presentations were delivered in 68 different sessions, both in English and Italian, on topics related specifically to the theme and also more general CALL topics. 94 of these were submitted as extended papers and appear in this volume of proceedings. An author index is included. (Individual papers contain references.)
- Published
- 2015
36. PSGL-1: A New Player in the Immune Checkpoint Landscape
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Tinoco, Roberto, Otero, Dennis C, Takahashi, Amy A, and Bradley, Linda M
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Immunology ,Vaccine Related ,Prevention ,Biodefense ,1.1 Normal biological development and functioning ,Underpinning research ,Inflammatory and immune system ,Generic health relevance ,Animals ,Cell Adhesion ,Cell Movement ,Humans ,Lymphocyte Activation ,Membrane Glycoproteins ,Models ,Immunological ,Receptors ,Antigen ,T-Cell ,Signal Transduction ,T-Lymphocytes ,Biochemistry and cell biology - Abstract
P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. However, recent findings indicate that PSGL-1 can also negatively regulate T cell function. Because T cell differentiation is finely tuned by multiple positive and negative regulatory signals that appropriately scale the magnitude of the immune response, PSGL-1 has emerged as an important checkpoint during this process. We summarize what is known regarding PSGL-1 structure and function and highlight how it may act as an immune checkpoint inhibitor in T cells.
- Published
- 2017
37. Sustainable digital support for job seekers distanced from the job market : innovation and learning through co-design
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Bradley, Linda, Mkansi, Marcia, Jungselius, Beata, Lantz Andersson, Annika, Bradley, Linda, Mkansi, Marcia, Jungselius, Beata, and Lantz Andersson, Annika
- Published
- 2024
38. Applying Dynamic Assessment Principles to Online Peer Revisions in Written English for Specific Purposes
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Thouësny, Sylvie and Bradley, Linda
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The aim of this paper is to explore the extent of the applicability of dynamic assessment with respect to peer written student online revisions. More specifically, it observes how groups of Swedish computer engineering students learning English for Specific Purposes engage in cooperative interactions and negotiations with their peers as they work together towards the revision of a written report. Using Google Drive as a means to engage in their report writing assignment in groups of three, students also discussed their text with another group in a peer response activity through comment insertions. Following a discussion of the progressive scale used to provide assistance, learners' turns during corrections and revisions of linguistic, structural, and content features are analysed. Finally, implications for peer revisions and provision of feedback according to learners' developmental level are discussed in relation to the outcomes of the study. [For full proceedings, see ED565087.]
- Published
- 2014
39. CALL Design: Principles and Practice. Proceedings of the 2014 EUROCALL Conference (Groningen, The Netherlands, August 20-23, 2014)
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Research-publishing.net (France), Jager, Sake, Bradley, Linda, Meima, Estelle J., Jager, Sake, Bradley, Linda, Meima, Estelle J., and Research-publishing.net (France)
- Abstract
The theme of EUROCALL 2014 was "CALL Design: Principles and Practice," which attracted approximately 280 practitioners, researchers and students from computer-assisted language learning (CALL) and related disciplines of more than 40 different nationalities. Over 170 presentations were delivered on topics related to this overarching theme. The topics included: (1) Applying principles from second language acquisition (SLA) and task-based language teaching (TBLT) in CALL; (2) Applying specific instructional models in CALL; (3) Preparing and delivering open educational resources, open courseware and open online courses for language learning; (4) Designing for open and independent online language learning; (5) Using competence or outcome-based frameworks (Common European Framework of Reference, IATFL, etc.) in CALL design; (6) Designing, applying and evaluating computer-based language tests; (7) Applying corpus-based designs and technologies; (8) Learning analytics and CALL design; (9) Synchronous and asynchronous computer-mediated communication (CMC); (10) Gaming and virtual worlds; (11) Mobile apps for CALL; (12) Telecollaboration and Online Intercultural Exchanges; (13) Using NLP and AI-based designs and technologies; (14) Using specific design tools for CALL; (15) CALL for specific contexts and purposes (institutional setting, independent use); (16) CALL for specific skills; (17) Successful CALL project designs; and (18) Developing strategies for teacher education and professional development. The conference programme consisted of workshops, symposia, and presentations and poster sessions on research, research and development, reflective practice, and European projects relating to these areas. The keynote presentations also shed light from different perspectives on developments in CALL. Seventy-one extended versions of papers presented at the conference are included in these proceedings. The papers are representative of the great variety of subjects presented at EUROCALL 2014. An author index is included. (Individual papers contain references.)
- Published
- 2014
40. Faith Community Nurses Making a Difference for Older African Americans in a Pandemic
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Bradley, Linda
- Published
- 2022
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- View/download PDF
41. Implementation of Office Hysteroscopy for the Evaluation and Treatment of Intrauterine Pathology
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Orlando, Megan S. and Bradley, Linda D.
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- 2022
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42. Is the Art of Hysteroscopy in jeopardy? A wake-up call
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Moawad, Nash S., primary, Carugno, Jose, additional, and Bradley, Linda D., additional
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- 2024
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- View/download PDF
43. Abstract A051: PSGL-1-deficiency promotes pancreatic ductal adenocarcinoma tumor control and synergy with immune checkpoint blockade
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Hope, Jennifer L., primary, Zhang, Yijuan, additional, Faso, Hannah A., additional, Roy, Sreeja, additional, Lin, Michelle, additional, Palete, Ashley B., additional, Maganti, Swetha, additional, Otero, Dennis C., additional, Commisso, Cosimo, additional, and Bradley, Linda M., additional
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- 2024
- Full Text
- View/download PDF
44. PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion
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Tinoco, Roberto, Carrette, Florent, Barraza, Monique L, Otero, Dennis C, Magaña, Jonathan, Bosenberg, Marcus W, Swain, Susan L, and Bradley, Linda M
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Prevention ,Cancer ,Infectious Diseases ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Animals ,CD4-Positive T-Lymphocytes ,CD8-Positive T-Lymphocytes ,Disease Models ,Animal ,Humans ,Immune Evasion ,Interleukin-2 ,Lymphocyte Activation ,Lymphocytic Choriomeningitis ,Lymphocytic choriomeningitis virus ,Melanoma ,Membrane Glycoproteins ,Mice ,Mice ,Inbred C57BL ,Mice ,Knockout ,Programmed Cell Death 1 Receptor ,Receptors ,Antigen ,T-Cell ,Signal Transduction ,P-selectin glycoprotein ligand-1 ,T cell exhaustion ,cancer ,immunopathology ,inhibitory receptors ,lymphocytic choriomeningitis virus clone 13 ,melanoma ,programmed death-1 - Abstract
Chronic viruses and cancers thwart immune responses in humans by inducing T cell dysfunction. Using a murine chronic virus that models human infections, we investigated the function of the adhesion molecule, P-selectin glycoprotein ligand-1 (PSGL-1), that is upregulated on responding T cells. PSGL-1-deficient mice cleared the virus due to increased intrinsic survival of multifunctional effector T cells that had downregulated PD-1 as well as other inhibitory receptors. Notably, this response resulted in CD4(+)-T-cell-dependent immunopathology. Mechanistically, PSGL-1 ligation on exhausted CD8(+) T cells inhibited T cell receptor (TCR) and interleukin-2 (IL-2) signaling and upregulated PD-1, leading to diminished survival with TCR stimulation. In models of melanoma cancer in which T cell dysfunction occurs, PSGL-1 deficiency led to PD-1 downregulation, improved T cell responses, and tumor control. Thus, PSGL-1 plays a fundamental role in balancing viral control and immunopathology and also functions to regulate T cell responses in the tumor microenvironment.
- Published
- 2016
45. 20 Years of EUROCALL: Learning from the Past, Looking to the Future. Proceedings [of the] 2013 EUROCALL Conference (Évora, Portugal, September 11-14, 2013)
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Research-publishing.net (France), Bradley, Linda, Thouësny, Sylvie, Bradley, Linda, Thouësny, Sylvie, and Research-publishing.net (France)
- Abstract
EUROCALL 2013's theme was "20 Years of EUROCALL: Learning from the Past, Looking to the Future." The conference seeked to establish an overview of EUROCALL's twentieth anniversary. As a professional organization, EUROCALL has been aiming, along its 20 years of existence, to promote innovative research, development and practice in the area of Computer Assisted Language Learning (CALL) and Technology Enhanced Language Learning (TELL) in education and training. During 20 years the organization has brought together educators, researchers, PhD students, administrators, designers of software and language learning systems, government representatives, equipment and software suppliers and other professionals involved in CALL and TELL. Some of the areas covered during the conference were: (1)???? Recent developments in mobile learning; (2)???? Language learning in virtual environments; ????(3) Synchronous communication in language learning; (4) European Language Portfolio, self assessment and ICT; ????(5) Challenges of e-learning: the role of the institution; ????(6) E-learning: student expectations and experience; ????(7) Successes of e-learning through the eyes of the student; ????(8) The use of new technologies for language teaching in schools; ????(9) Promoting the use of new technologies amongst language teaching professionals; ????(10) Developments in the pedagogy of online learning; ????(11) Corpora and language learning; (12) Courseware design; ??(13) Cross-sector collaboration through e-learning; ????(14) Supporting less widely taught languages through CALL; ????(15) Improving intercultural competence through language learning; ????(16) Managing multimedia environments; ????(17) Distance and collaborative learning; and (18) Self access and learner autonomy. An author index and a name index are included. (Individual papers contain references.)
- Published
- 2013
46. CALL: Using, Learning, Knowing. Proceedings of the 2012 EUROCALL Conference (Gothenburg, Sweden, August 22-25, 2012)
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Research-publishing.net (France), Bradley, Linda, and Thouësny, Sylvie
- Abstract
For the first time, the annual conference of the European Association for Computer-Assisted Language Learning (EUROCALL) took place in Sweden. The conference took place at the Faculty of Education on historic ground on the old fortification walls of Carolus Dux from the 17th century right in the centre of the city. This year's host comprised the University of Gothenburg in collaboration with Chalmers University of Technology. The local committee members represented three collaborating institutions: "Faculty of Education, the University of Gothenburg"; "Department of Languages and Literatures, the University of Gothenburg"; and "Division for Language and Communication, Chalmers University of Technology." This year's conference theme was "CALL: using, learning, knowing." The conference seeked to establish the current state of the art, how using technologies shape what and how we learn, and what we consider we know from research and development within CALL. These three dimensions are in a continuous fux and interplay as an upward spiral, contributing together to create a dynamic learning experience for the student. There were presentations presented at the conference. 59 of these were submitted as extended papers and appear in this volume of proceedings. An author index is included. (Individual papers contain references.)
- Published
- 2012
47. Second Language Teaching and Learning with Technology: Views of Emergent Researchers
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Research-publishing.net (France), Thouësny, Sylvie, Bradley, Linda, Thouësny, Sylvie, Bradley, Linda, and Research-publishing.net (France)
- Abstract
The aim of this book was to present innovative applications of technology in second language teaching and learning, as well as to explore the transformation of the different techniques to different theoretical frameworks. It has also been desired to have a representation of researchers from different parts of the world as contributors. When the reviewing process was finished, there were nine selected chapters from seven different countries: Canada, Finland, France, Ireland, Spain, Sweden, and Singapore. Thus, the chapters of this book consist of the work of eleven young researchers within the field of net-based language learning. These nine chapters all deal with topical areas of Internet-based Computer-assisted language learning (CALL). Following Notes on Contributors, Acknowledgements, and Foreword, the following papers are included in this book: (1) Introduction on Views of Emergent Researchers in L2 Teaching and Learning with Technology (Sylvie Thouësny and Linda Bradley); (2) Personal Learning Environments in Higher Education Language Courses: An Informal and Learner-Centred Approach (Ilona Laakkonen); (3) QuickAssist: Reading and Learning Vocabulary Independently with the Help of CALL and NLP Technologies (Peter Wood); (4) Self-Assessment and Tutor Assessment in Online Language Learning Materials: InGenio FCE Online Course and Tester (Ana Sevilla-Pavón, Antonio Martínez-Sáez, and José Macario de Siqueira); (5) Mobile-Assisted Language Learning: Designing for Your Students (Agnieszka Palalas); (6) A Design for Intercultural Exchange--An Analysis of Engineering Students' Interaction with English Majors in a Poetry Blog (Linda Bradley, Berner Lindström, Hans Rystedt, and Magnus Gustafsson); (7) Developing Sociolinguistic Competence through Intercultural Online Exchange (Mathy Ritchie); (8) Second Language Learning by Exchanging Cultural Contexts through the Mobile Group Blog (Yinjuan Shao); (9) Dynamically Assessing Written Language: To what Extent Do Learners of French Language Accept Mediation? (Sylvie Thouësny); and (10) Computer-Mediated Negotiated Interactions: How is Meaning Negotiated in Discussion Boards, Text Chat and Videoconferencing? (Cédric Sarré). A name index is included. (Individual papers contain references.)
- Published
- 2011
48. Introduction on Views of Emergent Researchers in L2 Teaching and Learning with Technology
- Author
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Thouësny, Sylvie and Bradley, Linda
- Abstract
Although technology has become embedded in our everyday life, researchers and practitioners constantly strive to find ways of incorporating technology in education, with language learning being one of those fields (Garrett, 2009). Numerous publications on this subject are available, mostly on condition that one is affiliated with a university, and that this university subscribes to a broad spectrum of publications. With the aim of widening free access research publications, we have elaborated a peer-reviewed eBook published under a Creative Commons licence which provides not only protection but also freedom for authors and editors. Young researchers from a variety of countries participated with a chapter of their ongoing projects. The themes approached within these projects represent topical areas of language learning and teaching, and technology within collaborative, personal and virtual learning environments. After providing an overview of the steps taken to develop this eBook project, this chapter gives a brief account of the innovative applications of technology in second language teaching and learning found in the eBook. [For the complete volume, "Second Language Teaching and Learning with Technology: Views of Emergent Researchers," see ED574599.]
- Published
- 2011
49. A Design for Intercultural Exchange--An Analysis of Engineering Students' Interaction with English Majors in a Poetry Blog
- Author
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Bradley, Linda, Lindström, Berner, Rystedt, Hans, and Gustafsson, Magnus
- Abstract
Web based writing platforms allowing for exchanges across the world are increasingly being used in education. These recent forms of textual practice are highly related to conditions offered by the technology, allowing users, who previously were primarily consumers, to become producers of text. This chapter investigates student interaction over a blog in an intercultural student exchange between native speakers and nonnative speakers of English in higher education analysing and interpreting poetry. The groups of students involved in this study belong not only to different academic disciplines, but also differ in terms of nationality and language background. In the blog posts, the students' cultural voices are heard, offering a meeting between very contrasting groups. Scrutinising the student postings, the threaded discussions show ways that students thematise content and meaning in the poems. The results show that there are a number of features at play in an intercultural environment where language and translation issues are prominent parts of the student discussions, offering extended perspectives to the students' initial views. Collaborative efforts in such a diverse environment are important when negotiating meaning and extending students' understanding of poetry. [For the complete volume, "Second Language Teaching and Learning with Technology: Views of Emergent Researchers," see ED574599.]
- Published
- 2011
50. Language Learning in a Wiki: Student Contributions in a Web Based Learning Environment
- Author
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Bradley, Linda, Lindström, Berner, Rystedt, Hans, and Vigmo, Sylvi
- Abstract
Emerging social writing platforms offer possibilities for language learners to collaborate around joint assignments. One such environment is the wiki, generally hosting two prominent modes of usage, web pages and discussion forums. This study investigates software engineering students' use of a wiki as an integrated tool within the frames of a language course. The purpose of the case study was to investigate the student interaction in a student driven design setting and what the implications are for language learning in such an environment. The findings show that the two modes of interaction host primarily three types of activity, contributing and writing together, evaluating and peer reviewing, and arguing and discussing. These three activities convey different ways of collaborating and sharing text online. Once a group had chosen a mode for their collaboration, they tend to stay with it throughout their work.
- Published
- 2010
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