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33 results on '"Bourcigaux, Nathalie"'

2. Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol)

Author

Fiot, Elodie, Alauze, Bertille, Donadille, Bruno, Samara-Boustani, Dinane, Houang, Muriel, De Filippo, Gianpaolo, Bachelot, Anne, Delcour, Clemence, Beyler, Constance, Bois, Emilie, Bourrat, Emmanuelle, Bui Quoc, Emmanuel, Bourcigaux, Nathalie, Chaussain, Catherine, Cohen, Ariel, Cohen-Solal, Martine, Da Costa, Sabrina, Dossier, Claire, Ederhy, Stephane, Elmaleh, Monique, Iserin, Laurence, Lengliné, Hélène, Poujol-Robert, Armelle, Roulot, Dominique, Viala, Jerome, Albarel, Frederique, Bismuth, Elise, Bernard, Valérie, Bouvattier, Claire, Brac, Aude, Bretones, Patricia, Chabbert-Buffet, Nathalie, Chanson, Philippe, Coutant, Regis, de Warren, Marguerite, Demaret, Béatrice, Duranteau, Lise, Eustache, Florence, Gautheret, Lydie, Gelwane, Georges, Gourbesville, Claire, Grynberg, Mickaël, Gueniche, Karinne, Jorgensen, Carina, Kerlan, Veronique, Lebrun, Charlotte, Lefevre, Christine, Lorenzini, Françoise, Manouvrier, Sylvie, Pienkowski, Catherine, Reynaud, Rachel, Reznik, Yves, Siffroi, Jean-Pierre, Tabet, Anne-Claude, Tauber, Maithé, Vautier, Vanessa, Tauveron, Igor, Wambre, Sebastien, Zenaty, Delphine, Netchine, Irène, Polak, Michel, Touraine, Philippe, Carel, Jean-Claude, Christin-Maitre, Sophie, and Léger, Juliane

Published
2022
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5. Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial

Author

Sénat, Marie-Victoire, Affres, Helene, Letourneau, Alexandra, Coustols-Valat, Magali, Cazaubiel, Marie, Legardeur, Helene, Jacquier, Julie Fort, Bourcigaux, Nathalie, Simon, Emmanuel, Rod, Anne, Héron, Isabelle, Castera, Virginie, Sentilhes, Loic, Bretelle, Florence, Rolland, Catherine, Morin, Mathieu, Deruelle, Philippe, De Carne, Celine, Maillot, François, Beucher, Gael, Verspyck, Eric, Desbriere, Raoul, Laboureau, Sandrine, Mitanchez, Delphine, and Bouyer, Jean

Published
2018
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6. Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients

Author

Burman, Pia, primary, Trouillas, Jacqueline, additional, Losa, Marco, additional, McCormack, Ann, additional, Petersenn, Stephan, additional, Popovic, Vera, additional, Theodoropoulou, Marily, additional, Raverot, Gerald, additional, Dekkers, Olaf M, additional, Guenego, Agathe, additional, Micko, Alexander, additional, Hubalewska-Dydejezky, Alicia, additional, Troendle, Amineh, additional, Krogh Rasmussen, Åse, additional, Whitelaw, Ben, additional, Decoudier, Benedicte, additional, Ekman, Bertil, additional, Engström, Britt Eden, additional, Höybye, Charlotte, additional, Jublanc, Christel, additional, Cortet Rudelli, Christine, additional, Higham, Claire, additional, Garcia, Cyril, additional, Bresson, Damien, additional, Henley, David, additional, Larrieu-Ciron, Delphine, additional, Maiter, Dominique, additional, Laws, Edward R, additional, Christ, Emanuel, additional, Kuhn, Emmanuelle, additional, Ceccato, Filippo, additional, Schillo, Franck, additional, Castinetti, Frederic, additional, Mantovani, Giovanna, additional, Vila, Greisa, additional, Lasolle, Helene, additional, Garay, Ismene Bilbao, additional, Kralievic, Ivana, additional, Otto Lunde Jorgensen, Jens, additional, Berinder, Katarina, additional, Ritzel, Katrin, additional, Bach, Leon, additional, Ortiz, Leon D, additional, Criniere, Lise, additional, Syro, Luis, additional, Haissaguerre, Magalie, additional, Zatelli, Maria Chiara, additional, Batisse-Lignier, Marie, additional, Jaffrain-Rea, Marie-Lise, additional, Korbonits, Marta, additional, Ragonese, Marta, additional, Reincke, Martin, additional, Toth, Miklos, additional, Bourcigaux, Nathalie, additional, Chevalier, Nicolas, additional, Ragnarsson, Oskar, additional, Chanson, Philippe, additional, Burman, Pia, additional, Pekic, Sandra, additional, Mallea-Gil, Susana, additional, Usui, Takeshi, additional, Deutschbein, Timo, additional, Mazzuco, Tania Longo, additional, Dusek, Tina, additional, Feldt-Rasmussen, Ulla, additional, and Greenman, Yona, additional

Published
2022
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7. Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients

Author

Burman, Pia, Trouillas, Jacqueline, Losa, Marco, McCormack, Ann, Petersenn, Stephan, Popovic, Vera, Theodoropoulou, Marily, Raverot, Gerald, Dekkers, Olaf M, Guenego, Agathe, Micko, Alexander, Hubalewska-Dydejezky, Alicia, Troendle, Amineh, Krogh Rasmussen, Åse, Whitelaw, Ben, Decoudier, Benedicte, Ekman, Bertil, Engström, Britt Eden, Höybye, Charlotte, Jublanc, Christel, Cortet Rudelli, Christine, Higham, Claire, Garcia, Cyril, Bresson, Damien, Henley, David, Larrieu- Ciron, Delphine, Maiter, Dominique, Laws, Edward R., Christ, Emanuel, Kuhn, Emmanuelle, Ceccato, Filippo, Schillo, Franck, Castinetti, Frederic, Mantovani, Giovanna, Vila, Greisa, Lasolle, Helene, Garay, Ismene Bilbao, Kralievic, Ivana, Otto Lunde Jorgensen, Jens, Berinder, Katarina, Ritzel, Katrin, Bach, Leon, Ortiz, Leon D, Criniere, Lise, Syro, Luis, Haissaguerre, Magalie, Zatelli, Maria Chiara, Batisse-Lignier, Marie, Jaffrain- Rea, Marie-Lise, Korbonits, Marta, Ragonese, Marta, Reincke, Martin, Toth, Miklos, Bourcigaux, Nathalie, Chevalier, Nicolas, Ragnarsson, Oskar, Chanson, Philippe, Pekic, Sandra, Mallea- Gil, Susana, Usui, Takeshi, Deutschbein, Timo, Mazzuco, Tania Longo, Dusek, Tina, Feldt- Rasmussen, Ulla, Greenman, Yona, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, and UCL - (SLuc) Service d'endocrinologie et de nutrition

Subjects
Male, Radioisotopes, Adenoma, Pituitary tumors, PitNETs, temozolomide, pituitary carcinoma, Receptors, Peptide, Aggressive pituitary tumours, Endocrinology, Diabetes and Metabolism, Carcinoma, Pituitary tumors, General Medicine, pituitary carcinoma, PitNETs, Bevacizumab, Endocrinology, Ki-67 Antigen, Adrenocorticotropic Hormone, Receptors, Peptide, Temozolomide, Humans, Female, Pituitary Neoplasms, Tumor Suppressor Protein p53, Immune Checkpoint Inhibitors
Abstract

Objective To describe clinical and pathological characteristics and treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC). Design Electronic survey August 2020–May 2021. Results 96% of 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven tumours, initially considered clinically benign, demonstrated aggressive behaviour after 5.5 years (IQR: 2.8–12). Of the patients, 63% were men. Adrenocorticotrophic hormone (ACTH)-secreting tumours constituted 30% of the APT/PC, and the gonadotroph subtypes were under-represented. Five out of 13 silent corticotroph tumours and 2/6 silent somatotroph tumours became secreting. Metastases were observed after median 6.3 years (IQR 3.7–12.1) from diagnosis. At the first surgery, the Ki67 index was ≥3% in 74/93 (80%) and ≥10% in 38/93 (41%) tumours. An absolute increase of Ki67 ≥ 10% after median of 6 years from the first surgery occurred in 18/49 examined tumours. Tumours with an aggressive course from outset had higher Ki67, mitotic counts, and p53. Temozolomide treatment in 156/171 patients resulted in complete response in 9.6%, partial response in 30.1%, stable disease in 28.1%, and progressive disease in 32.2% of the patients. Treatment with bevacizumab, immune checkpoint inhibitors, and peptide receptor radionuclide therapy resulted in partial regression in 1/10, 1/6, and 3/11, respectively. Median survival in APT and PC was 17.2 and 11.3 years, respectively. Tumours with Ki67 ≥ 10% and ACTH-secretion were associated with worse prognosis. Conclusion APT/PCs exhibit a wide and challenging spectrum of behaviour. Temozolomide is the first-line chemotherapy, and other oncological therapies are emerging. Treatment response continues to be difficult to predict with currently studied biomarkers.

Published
2022
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9. Influenza vaccination and prognosis of COVID ‐19 in hospitalized patients with diabetes: Results from the CORONADO study

Author

Diallo, A, Pichelin, Matthieu, Wargny, Matthieu, Gourdy, Pierre, Bonnet, JB, Hadjadj, Samy, Cariou, Bertrand, Sultan, Ariane, Galtier, Florence, Mahot, Pascale, Fournier‐Guilloux, Anne‐Laure, Mauduit, Nicolas, Bigot‐corbel, Edith, Boureau, Anne‐Sophie, Dekcer, Laure, Ernould, Audrey, Primot, Claire, Seguin, Anne, Joliveau, Marielle, Pouvreau, Sonia, FOURNIER, Chloé, Thureau, Jeremy, Fonteneau, Edith, Hublain, Pamela, Nantes, Chu, Agasse, Carole, Kergaradec, Mathilde DE, Minville, Vincent, Vardon‐Bounes, Fanny, Martin‐Blondel, Guillaume, Tramunt, Blandine, Turnin, Marie‐Christine, Hanaire, Hélène, Mansuy, Jean‐Michel, Fabre, Didier, Arhainx, Marie‐Blanche, Cazals, Laurent, Combes, Laure, Lami, Emmanuelle, Cianferani, Mallory, Megarbane, Bruno, Leroy, Pierre, Gautier, Jean‐François, Vidal‐Trecan, Tiphaine, Riveline, Jean‐Pierre, Laplanche, Jean‐Louis, Mouly, Stéphane, Potier, Louis, Roussel, Ronan, Taher, Malak, Abouleka, Yawa, Yaker, Fetta, Carlier, Aurelie, Boutten, Anne, Hallot‐Feron, Marilyne, Mourah, Fadila, Thivolet, Charles, Blond, Emilie, Rolland, Muriel, Mendez, Josep Verdecho, Alexandre, Marine, Pottecher, Julien, Richer, Emilie, Meyer, Laurent, Luca, Florina, Lessinger, Jean‐Marc, Bahougne, Thibault, Guerci, Bruno, Ludwig, Lisa, Benzirar, Siham, Malaplate, Catherine, Matton, Thierry, Poissy, Julien, Faure, Karine, Fontaine, Pierre, Baudoux, Florence, Vambergue, Anne, Pekar, Jean David, Lambert, Marc, Yelnik, Cécile, Bruandet, Amélie, Petit, Laurent, Neau, Didier, Rigalleau, Vincent, Berard, Annie, Galioot, Amandine, Coudroy, Remy, Thille, Arnaud, Robert, René, Roblot‐Cazenave, France, Rammaert, Blandine, Saulnier, Pierre Jean, Piguel, Xavier, Benhenda, Nesrine, Husson, Camille, Olivier, Celine, Torremocha, Florence, Fraty, Mathilde, d'assigny, Marie Flamen, Miot, Aurelie, Bossard, Valentin, Klouche, Kada, Makinson, Alain, Bonnet, Jean‐Baptiste, Foulongne, Vincent, Aubron, Cécile, Ansart, Séverine, Kerlan, Véronique, Quiniou, Pascale, Carre, Jean‐Luc, Quesnot, Stéphane, Laviolle, Bruno, Schwebel, Carole, Epaulard, Olivier, Benhamou, Pierre‐Yves, Betry, Cécile, Borel, Anne‐Laure, Lablanche, Sandrine, Guergour, Dorra, Duclos, Catherine, Cosson, Emmanuel, Guyot, Erwan, Deniau, Aurore, Nguyen, Phucthutrang, Reznik, Yves, Joubert, Michael, Allouche, Stéphane, Guittet, Lydia, Grange, Steven, Etienne, Manuel, Prévost, Gaëtan, Brunel, Valéry, Lagier, Jean‐Christophe, Raoult, Didier, Dutour, Anne, Gaborit, Bénédicte, Boulllu, Sandrine, Darmon, Patrice, Lasbleiz, Adèle, Cerino, Mathieu, Romain, Fanny, Houssays, Marie, Quenot, Jean Pierre, Piroth, Lionel, Vergès, Bruno, Duvillard, Laurence, Bonnotte, Bernard, Mercat, Alain, Dubee, Vincent, Allix, Ingrid, Rodien, Patrice, Dhersin, Robin, Lebeault, Maylis, Trzepizur, Wojciech, Loison, Jocelyne, Brangier, Antoine, Asfar, Pierre, Reynier, Pascal, Larcher, Françoise, Joubaud, Françoise, Andreu, Marie‐Rita, Urbanski, Geoffrey, Hubert, Laurent, Annweiler, Cedric, Dellamonica, Jean, Courjon, Johan, Chevalier, Nicolas, Chinetti, Giulia, Chafai, Magda, Mourvillier, Bruno, Bani‐Sadr, Firouze, Barraud, Sarra, Delemer, Brigitte, Gillery, Philippe, Labedade, Pascale, Chabrol, Amélie, Penfornis, Alfred, Petit, Catherine, Amadou, Coralie, Adler, Maxime, Dubost, Clément, Conan, Pierre‐Louis, Bordier, Lyse, Ceppa, Franck, Garcia, Cyril, Sollier, Mathilde, Dupuy, Olivier, Laplance, Sophie, Billuart, Olivier, Aroulanda, Marie Joseph, Olivier, Frédérique, Ayon, Florence, Wilhelm, Nathalie, Epelboin, Loic, Sabbah, Nadia, Charpin, Aurelie, Squara, Pierre, Belliard, Olivier, Dubois, Claude, Marre, Michel, Auchabie, Johann, Courtois, Roxane, Duriez, Thierry, Mergey, Tiphaine, Vallee, Laura, Seguin, Laetitia, Al‐Salameh, Abdallah, Lanoix, Jean‐Philippe, Soriot‐Thomas, Sandrine, Bourgeois‐Descouls, Anne‐Marie, Desailloud, Rachel, Germain, Natacha, Galusca, Bogdan, Belleton, Gwenaelle, Marouani, Nesrine, Palaghiu, Delia, Hammour, Amira, Berdaguer, Fernando, Klopfenstein, Thimothée, Zayet, Hajer, Winiszewski, Patrice, Zanusso, Marie, Garnier, Pauline, Julier, Ingrid, Hamzaoui, Karim, Marty‐Gres, Sophie, Sadki, Tarik, Cadot, Lucile, Dubost, Jean‐Louis, Gonfroy, Céline, Campinos, Catherine, Martres, Pascale, Coulhon, Marie Pierre, Allou, Nicolas, Bachir, Marwa, Hoang, Stella, Kembellec, Candice, Suply, Olivia, Kharcha, Fatima, Devouge, Anne‐Claire, Flaus‐Furmanuk, Anna, Madeline, Isabelle, Ehinger, Vincent, Bastard, Sophie, Raffray, Loic, Renou, Frederic, Bojarski, Aude, Paul, Caroline, Borsu, Karine, Gorlin, Angelique, Bernardo, Servane, Ut, Carole Truong, Renaud, Stephane, Vignoles, Antoine, Foch, Emilie, Masse, Laurie, Grand, Hubert, Ferrand, Helene, Raffaitin‐Cardin, Christelle, Zellagui, Hadjer, Castang‐Brachet, Celine, Boury, Frederique, Tena, Ana Alvarez, Moura, Isabelle, Kalfon, Pierre, Darasteanu, Juliana, Monier, Arnaud, Foucault, Pascal, Depuille, Alexandra, Laugier‐Robiolle, Stéphanie, Caneiro, Patrick, Basso, Maud, Larger, Etienne, Bouam, Samir, Benzenati, Wahiba, Bachir, Leila Ait, Pillegand, Camille Cussac, Vasse, Marc, Michard, Christophe, Montanier, Nathanaëlle, Millot, Luc, Crepet, Françoise, Ratsimba, Danielle, Bouiller, Kevin, Borot, Sophie, Bruckert, Isabelle, Clergeot, Annie, Schillo, Franck, Vignes, Dorothée, Bourgeon‐Ghittori, Muriel, Lachgar, Hamoud, Cursay, Claire Lambert DE, Levante, Stéphane, Auregan, Jean Charles, Merlet, Antoine, Zaragoza, Cécile, Arnault, Gwénaëlle, Loupp, Anne‐Gaëlle, Lesieur, Olivier, Roncato‐Saberan, Mariam, Gouet, Didier, Lemarie, Romain, Allano, Hong_an, Vivier, Emmanuel, Pariset, Caroline, Luyton, Cédric, Marchand, Lucien, Doroszewski, Fanny, Pecquet, Matthieu, Perard, Laurent, Vuillermoz‐Blas, Sylvie, Kacki, Nicolas, Charrier, Patricia, Ducet‐Boiffard, Amélie, Roure, Françoise Desroys, Bourron, Olivier, Bonnefont‐Rousselot, Dominique, Laroche, Suzanne, Phan, Franck, Hartemann, Agnès, CAUSSY, Cyrielle, Disse, Emmanuel, Guerin, Claude, Perpoint, Thomas, Moulin, Philippe, CARTIER, RÉGINE, Hariri, Geoffroy, Chopin, Dorothée, Vatier, Camille, Bourcigaux, Nathalie, Chaigneau, Emmanuelle, Christin‐Maitre, Sophie, Donadille, Bruno, Feve, Bruno, Lamothe, Sophie, Sarfati, Julie, Pernet, Pascal, Chambon, Anne, Demarsy, Delphine, Campagne, Hugo, Latil‐Plat, Françoise, Berne, Monica, Grinand, Marilyne, Touzet, Marion, Zabulon, Aydrey, Craspag, Jocelyne, Ledoux, Catherine, Contaret, Cedric, Janand‐Delenne, Blandine, Giraud, Anaïs, Lacrimini, Marie Lou, Arrivie, Joëlle, Ancelle, Deborah, Guillois, Carine, Fremy, Bénédicte, Chaalal, Amina, Barrande, Gaëlle, Dorange, Anne, Rouanet, Eglantine, Seret‐Begue, Dominique, Saoud, Audrey, Guedj, Anne‐Marie, Bedos, Nathalie, Velayoudom, Fritz‐Line, Dumas, Marie, Gonda, Benoite, Coffin, Christine, Gibiat, Stéphanie, Lungo, Myriam, Bully, Chantal, Serusclat, Pierre, Bully, Stella, Carre, Patricia, Leberre, Jean‐Philippe, Elkhoury, Carlos, THIEUX, Marine, Paradisi‐Prieur, Laetitia, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Hospitalized patients, Influenza vaccine, Endocrinology, Diabetes and Metabolism, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), [SDV]Life Sciences [q-bio], 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, Influenza, Human, Internal Medicine, Diabetes Mellitus, Research Letter, Medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, business.industry, SARS-CoV-2, Vaccination, COVID-19, medicine.disease, Prognosis, Research Letters, 3. Good health, Hospitalization, Propensity score matching, business
Abstract

International audience

Published
2021
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17. Impact on testicular function of a single ablative activity of 3.7 GBq radioactive iodine for differentiated thyroid carcinoma

Author

Bourcigaux Nathalie, Rubino Carole, Berthaut Isabelle, Bruno Donadille, Toubert Marie Elisabeth, Leenhardt Laurence, Corone Catherine, Petrot-Keller Isabelle, Brailly-Tabard Sylvie, Beaufaron Julie, Simon Tabassome, Siffroi Jean-Pierre, Vathaire Florent De, Sclumberger Martin, Bouchard Philippe, Christin-Maitre Sophie, Centre de Ressources Biologiques HUEP-UPMC (CRB HUEP-UPMC), UMS omique (OMIQUE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), and BRUNEL, Nadège

Subjects
[SDV] Life Sciences [q-bio], endocrine system, [SDV]Life Sciences [q-bio]
Abstract

International audience; Thirty six patients were included in the study. At V0, all patients had normal gonadal function. At V3, FSH median levels were significantly increased as compared to V0, respectively 9 UI/l±4.8 (N: 3–7 UI/l) versus 4 UI/l±3 (P

Published
2017

18. Treatment of aggressive pituitary tumours and carcinomas: results of a European Society of Endocrinology (ESE) survey 2016

Author

McCormack, Ann, primary, Dekkers, Olaf M, additional, Petersenn, Stephan, additional, Popovic, Vera, additional, Trouillas, Jacqueline, additional, Raverot, Gerald, additional, Burman, Pia, additional, _, _, additional, Hubalewska-Dydejezky, Alicia, additional, Assie, Guillaume, additional, Bach, Leon, additional, Batisse-Lignier, Marie, additional, Berinder, Katarina, additional, Bilbao, Ismene, additional, Bonnet, Fabrice, additional, Bresson, Damien, additional, Bruno, Oscar, additional, Campdera, Mariana, additional, Caron, Philippe, additional, Castinetti, Frederic, additional, Ceccato, Filippo, additional, Chabre, Olivier, additional, Chanson, Philippe, additional, Christ, Emanuel, additional, Cloix, Lucie, additional, Cortet, Christine, additional, Criniere, Lise, additional, Cuatrecasas, Guillem, additional, Debono, Miguel, additional, Delemer, Brigitte, additional, Desailloud, Rachel, additional, Deutschbein, Timo, additional, Dusek, Tina, additional, Engström, Britt Eden, additional, Faustini-Fustini, Marco, additional, Franck, Schillo, additional, Garcia, Cyril, additional, Greenman, Yona, additional, Gil, Susana Mallea, additional, Mantovani, Giovanna, additional, Gurnell, Mark, additional, Heaney, Anthony, additional, Henley, David, additional, Higham, Claire, additional, Hoving, EW, additional, Höybye, Charlotte, additional, Ichihara, Atsuhiro, additional, Jaffrain-Rea, Marie-Lise, additional, Johannsson, Gudmundur, additional, Jorgensen, Jens Otto Lunde, additional, Jublanc, Christel, additional, Komor, Jan, additional, Korbonits, Marta, additional, Kralievic, Ivana, additional, Larrieu-Ciron, Delphine, additional, Lasolle, Helene, additional, Laws, Edward, additional, Losa, Marco, additional, Maiter, Dominique, additional, Marcocci, Claudio, additional, Marques, Olinda Castro, additional, Mazzuco, Tania Longo, additional, Micko, Alexander, additional, Bourcigaux, Nathalie, additional, Neggers, Sebastian, additional, Newell-Price, John, additional, Perez-Berida, Belén, additional, Ortiz, Leon D, additional, Ragnarsson, Oskar, additional, Ragonese, Marta, additional, Reincke, Martin, additional, Sadoul, Jean-Louis, additional, Shimatsu, Akira, additional, Syro, Luis V, additional, Taillandier, Luc, additional, Toth, Miklos, additional, Usui, Takeshi, additional, Valkusz, Zauzsanna, additional, Vila, Greisa, additional, Whitelaw, Ben, additional, and Zatelli, Maria Chiara, additional

Published
2018
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19. Complex Association of Sex Hormones on Left Ventricular Systolic Function: Insight into Sexual Dimorphism

Author

Salem, Joe-Elie, primary, Nguyen, Lee S., additional, Hammoudi, Nadjib, additional, Preud'homme, Gisèle, additional, Hulot, Jean-Sebastien, additional, Leban, Monique, additional, Funck-Brentano, Christian, additional, Touraine, Philippe, additional, Isnard, Richard, additional, Bachelot, Anne, additional, Chanson, Philippe, additional, Salenave, Sylvie, additional, Christin Maitre, Sophie, additional, Bourcigaux, Nathalie, additional, Dulon, Jérôme, additional, Dahmoune, Nora, additional, Polak, Michel, additional, and Leger, Juliane, additional

Published
2018
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21. Temozolomide treatment can improve overall survival in aggressive pituitary tumors and pituitary carcinomas

Author

Lasolle, Hélène, primary, Cortet, Christine, additional, Castinetti, Fréderic, additional, Cloix, Lucie, additional, Caron, Philippe, additional, Delemer, Brigitte, additional, Desailloud, Rachel, additional, Jublanc, Christel, additional, Lebrun-Frenay, Christine, additional, Sadoul, Jean-Louis, additional, Taillandier, Luc, additional, Batisse-Lignier, Marie, additional, Bonnet, Fabrice, additional, Bourcigaux, Nathalie, additional, Bresson, Damien, additional, Chabre, Olivier, additional, Chanson, Philippe, additional, Garcia, Cyril, additional, Haissaguerre, Magalie, additional, Reznik, Yves, additional, Borot, Sophie, additional, Villa, Chiara, additional, Vasiljevic, Alexandre, additional, Gaillard, Stephan, additional, Jouanneau, Emmanuel, additional, Assié, Guillaume, additional, and Raverot, Gérald, additional

Published
2017
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22. Impacts of a single ablative dose of radio iodine therapy for differentiated thyroid carcinoma on testicular function: results from the SAPIRA study

Author

Bourcigaux, Nathalie, primary, Rubino, Carole, additional, Berthaut, Isabelle, additional, Donadille, Bruno, additional, Toubert, Marie Elisabeth, additional, Leenhardt, Laurence, additional, Corone, Catherine, additional, Petrot-Keller, Isabelle, additional, Brailly-Tabard, Sylvie, additional, Beaufaron, Julie, additional, Simon, Tabassome, additional, Siffroi, Jean-Pierre, additional, De, Vathaire Florent, additional, Sclumberger, Martin, additional, Bouchard, Philippe, additional, and Christin-Maitre, Sophie, additional

Published
2017
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24. Cardiovascular findings and management in Turner syndrome: insights from a French cohort

Author

Donadille, Bruno, primary, Rousseau, Alexandra, additional, Zenaty, Delphine, additional, Cabrol, Sylvie, additional, Courtillot, Carine, additional, Samara-Boustani, Dinane, additional, Salenave, Sylvie, additional, Monnier-Cholley, Laurence, additional, Meuleman, Catherine, additional, Jondeau, Guillaume, additional, Iserin, Laurence, additional, Duranteau, Lise, additional, Cabanes, Laure, additional, Bourcigaux, Nathalie, additional, Bonnet, Damien, additional, Bouchard, Philippe, additional, Chanson, Philippe, additional, Polak, Michel, additional, Touraine, Philippe, additional, Lebouc, Yves, additional, Carel, Jean-Claude, additional, Léger, Juliane, additional, and Christin-Maitre, Sophie, additional

Published
2012
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25. Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure

Author

Laissue, Paul, primary, Christin-Maitre, Sophie, additional, Touraine, Philippe, additional, Kuttenn, Frederique, additional, Ritvos, Olli, additional, Aittomaki, Kristiina, additional, Bourcigaux, Nathalie, additional, Jacquesson, Laetitia, additional, Bouchard, Philippe, additional, Frydman, Rene, additional, Dewailly, Didier, additional, Reyss, Anne-Céline, additional, Jeffery, Luke, additional, Bachelot, Anne, additional, Massin, Nathalie, additional, Fellous, Marc, additional, and Veitia, Reiner A, additional

Published
2006
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28. Mutations and sequence variants in GDF9and BMP15in patients with premature ovarian failure

Author

Laissue, Paul, Christin-Maitre, Sophie, Touraine, Philippe, Kuttenn, Frederique, Ritvos, Olli, Aittomaki, Kristiina, Bourcigaux, Nathalie, Jacquesson, Laetitia, Bouchard, Philippe, Frydman, Rene, Dewailly, Didier, Reyss, Anne-Céline, Jeffery, Luke, Bachelot, Anne, Massin, Nathalie, Fellous, Marc, and Veitia, Reiner A

Abstract

Background and objective: Mutations in bone morphogenic protein 15 (BMP15) and growth/differentiation factor 9 (GDF9) lead to altered fertility in animal models. In the human, a heterozygous point mutation of BMP15has been associated with premature ovarian failure (POF).Subject and methods: We have directly sequenced both genes in a cohort of 203 POF patients presenting with primary or secondary amenorrhea and high FSH levels and in a control population including 54 women with regular menstrual cycles who had at least one child.Results: We have identified several heterozygous variants. One alteration in GDF9 (S186Y) and one in BMP15 (L148P) may have pathogenic effects as both positions are conserved in vertebrate species, ranging from the chicken to mammals. These variants were absent in the control samples. We also found synonymous and neutral substitutions.Conclusions: We propose that although mutations in BMP15and GDF9are not a major cause of ovarian insufficiency, they may be involved in POF.

Published
2006
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30. Treatment of aggressive pituitary tumours and carcinomas: Results of a European Society of Endocrinology (ESE) survey 2016

Author

Ann McCormack, Olaf M Dekkers, Stephan Petersenn, Vera Popovic, Jacqueline Trouillas, Gerald Raverot, Pia Burman, Alicia Hubalewska-Dydejezky, Guillaume Assie, Leon Bach, Marie Batisse-Lignier, Katarina Berinder, Ismene Bilbao, Fabrice Bonnet, Damien Bresson, Oscar Bruno, Mariana Campdera, Philippe Caron, Frederic Castinetti, Filippo Ceccato, Olivier Chabre, Philippe Chanson, Emanuel Christ, Lucie Cloix, Christine Cortet, Lise Criniere, Guillem Cuatrecasas, Miguel Debono, Brigitte Delemer, Rachel Desailloud, Timo Deutschbein, Tina Dusek, Britt Eden Engström, Marco Faustini-Fustini, Schillo Franck, Cyril Garcia, Yona Greenman, Susana Mallea Gil, Giovanna Mantovani, Mark Gurnell, Anthony Heaney, David Henley, Claire Higham, EW Hoving, Charlotte Höybye, Atsuhiro Ichihara, Marie-Lise Jaffrain-Rea, Gudmundur Johannsson, Jens Otto Lunde Jorgensen, Christel Jublanc, Jan Komor, Marta Korbonits, Ivana Kralievic, Delphine Larrieu-Ciron, Helene Lasolle, Edward Laws, Marco Losa, Dominique Maiter, Claudio Marcocci, Olinda Castro Marques, Tania Longo Mazzuco, Alexander Micko, Nathalie Bourcigaux, Sebastian Neggers, John Newell-Price, Belén Perez-Berida, Leon D Ortiz, Oskar Ragnarsson, Marta Ragonese, Martin Reincke, Jean-Louis Sadoul, Akira Shimatsu, Luis V Syro, Luc Taillandier, Miklos Toth, Takeshi Usui, Zauzsanna Valkusz, Greisa Vila, Ben Whitelaw, Maria Chiara Zatelli, Mccormack, Ann, Dekkers, Olaf M, Petersenn, Stephan, Popovic, Vera, Trouillas, Jacqueline, Raverot, Gerald, Burman, Pia, Harrison, Alex, Hubalewska-Dydejezky, Alicia, Assie, Guillaume, Bach, Leon, Batisse-Lignier, Marie, Berinder, Katarina, Bilbao, Ismene, Bonnet, Fabrice, Bresson, Damien, Bruno, Oscar, Campdera, Mariana, Caron, Philippe, Castinetti, Frederic, Ceccato, Filippo, Chabre, Olivier, Chanson, Philippe, Christ, Emanuel, Cloix, Lucie, Cortet, Christine, Criniere, Lise, Cuatrecasas, Guillem, Debono, Miguel, Delemer, Brigitte, Desailloud, Rachel, Deutschbein, Timo, Dusek, Tina, Engström, Britt Eden, Faustini-Fustini, Marco, Franck, Schillo, Garcia, Cyril, Greenman, Yona, Gil, Susana Mallea, Mantovani, Giovanna, Gurnell, Mark, Heaney, Anthony, Henley, David, Higham, Claire, Hoving, E. W., Höybye, Charlotte, Ichihara, Atsuhiro, Jaffrain-Rea, Marie-Lise, Johannsson, Gudmundur, Jorgensen, Jens Otto Lunde, Jublanc, Christel, Komor, Jan, Korbonits, Marta, Kralievic, Ivana, Larrieu-Ciron, Delphine, Lasolle, Helene, Laws, Edward, Losa, Marco, Maiter, Dominique, Marcocci, Claudio, Marques, Olinda Castro, Mazzuco, Tania Longo, Micko, Alexander, Bourcigaux, Nathalie, Neggers, Sebastian, Newell-Price, John, Perez-Berida, Belén, Ortiz, Leon D, Ragnarsson, Oskar, Ragonese, Marta, Reincke, Martin, Sadoul, Jean-Loui, Shimatsu, Akira, Syro, Luis V, Taillandier, Luc, Toth, Miklo, Usui, Takeshi, Valkusz, Zauzsanna, Vila, Greisa, Whitelaw, Ben, and Zatelli, Maria Chiara

Subjects
Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Medizin, pituitary carcinoma, Pituitary neoplasm, Neurosurgical Procedure, Neurosurgical Procedures, 0302 clinical medicine, Endocrinology, Pituitary tumour, aggressive pituitary tumour, pituitary carcinoma, temozolomide, Surveys and Questionnaires, Antineoplastic Combined Chemotherapy Protocols, Surveys and Questionnaire, Pituitary Neoplasm, Adenoma, Adolescent, Adult, Aged, Antineoplastic Agents, Alkylating, Bevacizumab, Capecitabine, Carcinoma, Carmustine, Child, Child, Preschool, DNA Modification Methylases, DNA Repair Enzymes, Dacarbazine, Europe, Female, Humans, Ki-67 Antigen, Middle Aged, Neoplasm Invasiveness, Pituitary Neoplasms, Societies, Medical, Temozolomide, Thalidomide, Tumor Suppressor Proteins, Young Adult, Cranial Irradiation, DNA Repair Enzyme, General Medicine, Alkylating, aggressive pituitary tumour, 3. Good health, Diabetes and Metabolism, 030220 oncology & carcinogenesis, Human, medicine.drug, medicine.medical_specialty, 030209 endocrinology & metabolism, Antineoplastic Agents, 03 medical and health sciences, Internal medicine, Medical, DNA Modification Methylase, medicine, Preschool, Neoplasm Invasivene, Tumor Suppressor Protein, Chemotherapy, Antineoplastic Combined Chemotherapy Protocol, Pituitary tumour, business.industry, medicine.disease, Concomitant, business, Societies, Progressive disease
Abstract

Objective To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and specifically report effects of temozolomide (TMZ) treatment. Design Electronic survey to ESE members Dec 2015–Nov 2016. Results Reports on 166 patients (40 PC, 125 APT, 1 unclassified) were obtained. Median age at diagnosis was 43 (range 4–79) years. 69% of the tumours were clinically functioning, and the most frequent immunohistochemical subtype were corticotroph tumours (45%). Ki-67 index did not distinguish APT from PC, median 7% and 10% respectively. TMZ was first-line chemotherapy in 157 patients. At the end of the treatment (median 9 cycles), radiological evaluation showed complete response (CR) in 6%, partial response (PR) in 31%, stable disease (SD) in 33% and progressive disease in 30%. Response was more frequent in patients receiving concomitant radiotherapy and TMZ. CR was seen only in patients with low MGMT expression. Clinically functioning tumours were more likely to respond than non-functioning tumours, independent of MGMT status. Of patients with CR, PR and SD, 25, 40 and 48% respectively progressed after a median of 12-month follow-up. Other oncological drugs given as primary treatment and to TMZ failures resulted in PR in 20%. Conclusion This survey confirms that TMZ is established as first-line chemotherapeutic treatment of APT/PC. Clinically functioning tumours, low MGMT and concurrent radiotherapy were associated with a better response. The limited long-term effect of TMZ and the poor efficacy of other drugs highlight the need to identify additional effective therapies.

Published
2018

31. Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial.

Author

Sénat MV, Affres H, Letourneau A, Coustols-Valat M, Cazaubiel M, Legardeur H, Jacquier JF, Bourcigaux N, Simon E, Rod A, Héron I, Castera V, Sentilhes L, Bretelle F, Rolland C, Morin M, Deruelle P, De Carne C, Maillot F, Beucher G, Verspyck E, Desbriere R, Laboureau S, Mitanchez D, and Bouyer J

Subjects
Administration, Oral, Adult, Blood Glucose analysis, Diabetes, Gestational blood, Female, Fetal Macrosomia etiology, Glyburide adverse effects, Humans, Hyperbilirubinemia etiology, Hypoglycemia chemically induced, Hypoglycemia etiology, Hypoglycemic Agents adverse effects, Infant, Newborn, Infant, Newborn, Diseases epidemiology, Injections, Subcutaneous, Insulin adverse effects, Pregnancy, Pregnancy Outcome, Diabetes, Gestational drug therapy, Fetal Macrosomia prevention & control, Glyburide therapeutic use, Hyperbilirubinemia prevention & control, Hypoglycemia prevention & control, Hypoglycemic Agents therapeutic use, Insulin therapeutic use
Abstract

Importance: Randomized trials have not focused on neonatal complications of glyburide for women with gestational diabetes., Objective: To compare oral glyburide vs subcutaneous insulin in prevention of perinatal complications in newborns of women with gestational diabetes., Design, Settings, and Participants: The Insulin Daonil trial (INDAO), a multicenter noninferiority randomized trial conducted between May 2012 and November 2016 (end of participant follow-up) in 13 tertiary care university hospitals in France including 914 women with singleton pregnancies and gestational diabetes diagnosed between 24 and 34 weeks of gestation., Interventions: Women who required pharmacologic treatment after 10 days of dietary intervention were randomly assigned to receive glyburide (n=460) or insulin (n=454). The starting dosage for glyburide was 2.5 mg orally once per day and could be increased if necessary 4 days later by 2.5 mg and thereafter by 5 mg every 4 days in 2 morning and evening doses, up to a maximum of 20 mg/d. The starting dosage for insulin was 4 IU to 20 IU given subcutaneously 1 to 4 times per day as necessary and increased according to self-measured blood glucose concentrations., Main Outcomes and Measures: The primary outcome was a composite criterion including macrosomia, neonatal hypoglycemia, and hyperbilirubinemia. The noninferiority margin was set at 7% based on a 1-sided 97.5% confidence interval., Results: Among the 914 patients who were randomized (mean age, 32.8 [SD, 5.2] years), 98% completed the trial. In a per-protocol analysis, 367 and 442 women and their neonates were analyzed in the glyburide and insulin groups, respectively. The frequency of the primary outcome was 27.6% in the glyburide group and 23.4% in the insulin group, a difference of 4.2% (1-sided 97.5% CI, -∞ to 10.5%; P=.19)., Conclusion and Relevance: This study of women with gestational diabetes failed to show that use of glyburide compared with subcutaneous insulin does not result in a greater frequency of perinatal complications. These findings do not justify the use of glyburide as a first-line treatment., Trial Registration: clinicaltrials.gov Identifier: NCT01731431.

Published
2018
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32. [Premature ovarian failures].

Author

Bricaire L, Laroche E, Bourcigaux N, Donadille B, and Christin-Maitre S

Subjects
Autoimmune Diseases complications, Chromosomes, Human, X, Female, Fragile X Syndrome genetics, Humans, Sex Chromosome Aberrations, Turner Syndrome genetics, Primary Ovarian Insufficiency chemically induced, Primary Ovarian Insufficiency genetics, Primary Ovarian Insufficiency immunology, Primary Ovarian Insufficiency therapy
Abstract

Premature ovarian failure (POF) is clinically suspected by amenorrhea and confirmed by an elevated FSH serum level above 40 mUI/L (even 20 mUI/L) twice, in a woman before the age of 40. Prevalence of POF is between 1 to 2% in women. In 90% of cases, no aetiology is identified. Obvious causes are chemotherapy, pelvic radiotherapy, ovarian surgery and diethylstilbestrol exposure in utero. A karyotype should be performed as Turner Syndrome is the most frequent genetic cause of POF. Some X abnormalities such as X deletion or X autosome translocation can be found. FMR1 pre-mutation (fragile X syndrome) should be searched for, even though no cases of mental retardation are known, in the family. Other genetic abnormalities can be suggested by associated symptoms (i.e.: FOXL2, SF1 mutations). Auto-immune aetiology can be suspected if other auto-immune features are present, however, there are no reliable auto-antibodies to confirm auto-immunity in POF. Treatment of POF is based on hormonal replacement therapy in order to avoid estrogen deficiency, suppress vasomotor symptoms and avoid bone loss as well as cardiovascular risk. Estrogens should be associated with progesterone or a progestin, at least up to the age of 51. Patients with POF should be informed that spontaneous pregnancies may occur (in 5% of cases). In case of desire of pregnancy, the patient should be oriented to a specialized unit for in vitro fertilization with oocyte donation. Psychological support is essential and should be part of the treatment. POF is associated with an increased risk of emotional distress and depression. No preventive treatment of POF is available so far., (Copyright © 2013 Elsevier Masson SAS. All rights reserved.)

Published
2013
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33. Treatment of hypoglycemia using combined glucocorticoid and recombinant human growth hormone in a patient with a metastatic non-islet cell tumor hypoglycemia.

Author

Bourcigaux N, Arnault-Ouary G, Christol R, Périn L, Charbonnel B, and Le Bouc Y

Subjects
Aged, Blood Glucose drug effects, Drug Therapy, Combination, Female, Fibroma pathology, Glucocorticoids administration & dosage, Human Growth Hormone administration & dosage, Humans, Hypoglycemia etiology, Insulin blood, Insulin-Like Growth Factor Binding Protein 3 metabolism, Insulin-Like Growth Factor I metabolism, Liver Neoplasms secondary, Pleural Neoplasms pathology, Prednisone administration & dosage, Recombinant Proteins administration & dosage, Recombinant Proteins therapeutic use, Glucocorticoids therapeutic use, Human Growth Hormone therapeutic use, Hypoglycemia drug therapy, Liver Neoplasms complications, Prednisone therapeutic use
Abstract

Background: Non-islet cell tumor hypoglycemia(NICTH) is a rare cause of recurrent hypoglycemia. It has been associated with the tumoral overproduction of high-molecular-weight insulin-like growth factor (IGF)-2 ("big IGF-2"). Big IGF-2 suppresses growth hormone (GH) biosynthesis and impairs the storage of IGFs by suppressing the formation of the GH-dependent ternary complexes containing IGF, IGF binding protein 3 (IGFBP-3), and acid-labile subunit (ALS). Thus, big IGF-2 exerts hypoglycemic activity. The only effective treatment of NICTH is surgery. However, in inoperable patients with NICTH, treatment of hypoglycemia may require high doses of glucocorticoid (30-60 mg/d [0.5-1.0 mg/kg x d]) or recombinant human GH (rhGH) (2.6-12.0 mg/d [0.043-0.20 mg/kg x d])., Objective: We hypothesized that the association of low doses of glucocorticoid and rhGH could be an effective therapy for hypoglycemia in inoperable patients with NICTH., Methods: A 3-phase treatment regimen was conducted in an inoperable 67-year-old woman with NICTH. Decreasing dosages of prednisone (from 30 to 10 mg/d [from 0.50 to 0.15 mg/kg x d]), followed by decreasing doses of rhGH (from 2.6 to 1.3 mg/d [from 0.043 to 0.016 mg/kg x d]), and then a combination of the lowest doses of each, were tested. Glucose, insulin, and IGF monitoring were performed at each of the 3 treatment phases., Results: Fasting plasma glucose (FPG) level was normalized and the IGF-1 concentration was increased with high-dose prednisone monotherapy (30 mg/d [0.50 mg/kg x d]) or rhGH (2.6 mg/d [0.043 mg/kg x d]). Prednisone monotherapy partially suppressed big IGF-2 secretion, and rhGH monotherapy acted on IGFBP-3 and ALS concentrations. FPG level was normalized with combined low-dose prednisone and rhGH, and this combination was more effective than high-dose monotherapy with either drug in reestablishing the IGF system. No adverse effects (AEs) were found., Conclusions: In this patient with inoperable NICTH, the combination of low doses of prednisone and rhGH was a successful long-term therapy for hypoglycemia, with no AEs. This therapy could be proposed for use in patients with inoperable NICTH.

Published
2005
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