137 results on '"Birkus, Gabriel"'
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2. Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy
3. 5′-Phosphonate modified oligoadenylates as potent activators of human RNase L
4. Synthesis of phosphonate derivatives of 2′-deoxy-2′-fluorotetradialdose d-nucleosides and tetradialdose d-nucleosides
5. Development and Characterization of a Chronic Hepatitis B Murine Model With a Mutation in the START Codon of an HBV Polymerase
6. Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus
7. Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver Cells
8. Multiparametric Flow Cytometry-Based Immunophenotyping of Mouse Liver Immune Cells
9. Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides
10. Corrigendum to “5′-Phosphonate modified oligoadenylates as potent activators of human RNase L” [Bioorg. Med. Chem. 56 (2022) 116632]
11. STING Agonist-Mediated Cytokine Secretion Is Accompanied by Monocyte Apoptosis
12. Catalytically-Active Complex of HIV-1 Integrase with a Viral DNA Substrate Binds Anti-Integrase Drugs
13. Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides
14. Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver Cells.
15. Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148
16. Lipid Nanoparticles for Broad‐Spectrum Nucleic Acid Delivery
17. Anti-HBV activity of retinoid drugs in vitro versus in vivo
18. No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides
19. Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties
20. Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors
21. Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment
22. Discovery of β-d-2′-deoxy-2′-α-fluoro-4′-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases
23. Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs
24. Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors
25. Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology
26. Molecular Determinants of GS-9620-Dependent TLR7 Activation
27. Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors
28. Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action
29. Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
30. Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat
31. Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620
32. Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C -Nucleoside Monophosphate Prodrug
33. Multiple Classes of Antiviral Agents Exhibit In Vitro Activity against Human Rhinovirus Type C
34. Metabolism and Antiretroviral Activity of Tenofovir Alafenamide in CD4+ T-Cells and Macrophages from Demographically Diverse Donors
35. Evaluation of the Effect of Cobicistat on the In Vitro Renal Transport and Cytotoxicity Potential of Tenofovir
36. Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines
37. Role of Cathepsin A and Lysosomes in the Intracellular Activation of Novel Anti-papillomavirus Agent GS-9191
38. Role of Cathepsin A and Lysosomes in the Intracellular Activation of Novel Antipapillomavirus Agent GS-9191
39. Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design
40. ChemInform Abstract: Interactions of 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (Cidofovir) Diphosphate with DNA Polymerases α, δ and ε*.
41. Abstract 3657: 6-(Het)aryl-7-Deazapurine Ribonucleosides as Potent Novel Cytostatic Agents that Interfere with RNA Synthesis
42. GS-9191 Is a Novel Topical Prodrug of the Nucleotide Analog 9-(2-Phosphonylmethoxyethyl)Guanine with Antiproliferative Activity and Possible Utility in the Treatment of Human Papillomavirus Lesions
43. GS-9219—A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non–Hodgkin's Lymphoma
44. Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and Other Tenofovir Phosphonoamidate Prodrugs by Human Proteases
45. Cathepsin A Is the Major Hydrolase Catalyzing the Intracellular Hydrolysis of the Antiretroviral Nucleotide Phosphonoamidate Prodrugs GS-7340 and GS-9131
46. The Substrate Activity of (S)-9-[3-Hydroxy-(2-phosphonomethoxy)Propyl]Adenine Diphosphate toward DNA Polymerases α, δ and ε
47. Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors
48. Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir: Comparison with Other Nucleoside Reverse Transcriptase Inhibitors
49. Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors
50. Metabolism and Antiretroviral Activity of Tenofovir Alafenamide in CD4+T-Cells and Macrophages from Demographically Diverse Donors
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