18 results on '"Bibi Aalia"'
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2. PHYSICIANS-PHARMACEUTICAL INTERACTION, WHERE DO WE STAND?
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Syed Sajid Hussain Shah, Bibi Aalia, Mubarak Zeb, and Ihsan Ullah
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malpractice ,medical ethics ,physician’s interaction ,pharmaceutical industry ,Medicine - Abstract
Introduction: The relationship between physicians and pharma industry is an old and significant one. This study was conducted to evaluate the relationship between doctors and sales representatives of different pharmaceutical companies. Moreover, it evaluates the conflict of interest arising from some unethical practices. Material & Methods: The study was conducted in the outpatient department of Ayub Teaching Hospital Abbottabad for a period of three months. The representatives of different pharmaceutical companies visiting the department of paediatrics were included in the study after informed consent. The data were recorded using a proforma having set of questions and then analysed using SSPS 24 software. Results: A total of 92 pharmaceutical company representatives were included in the study. Out of 92 representatives, 93.5% were given proper training. About 12% responded they openly gave incentives to doctors for boosting their company sales and 34.8% responded that doctors demanded personal gains from them. There is significant relationship between open incentive given to doctors and open demand by doctors (p = 0.005). Conclusion: Interaction of doctors with the pharmaceutical companies is complex and conflict of interest is there. On one hand pharmaceutical companies are not following code of conduct in promotion/sales of their products and on other hand a reasonable number of doctors are not following the ethical guidelines and are involved in malpractice.
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- 2022
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3. Paraquat Poisoning In Children – A Case Report
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Syed Sajid Hussain Shah and Bibi Aalia
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Poisoning ,Children ,Herbicide ,Paraquat ,Fatal ,Dentistry ,RK1-715 ,Medicine (General) ,R5-920 - Abstract
OBJECTIVES Accidental poisoning in children is a serious public health problem in developing countries, especially where chemicals used in agriculture are ingested. Paraquat is a herbicide which is still used in Pakistan. We report a case of fatal unintentional paraquat ingestion by 3 years old child who could not survive. Lack of care in the storage of paraquat lead to the poisoning but initial inappropriate management was also one factor in the fatal outcome. Detailed history and provision of poison containers are important in the proper management of patients with poisoning.
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- 2022
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4. Ivermectin Poisoning with Neurological Manifestations in 10 Years Old Girl – A Case Report
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Syed Sajid Hussain shah and Bibi Aalia
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Ivermectin ,Poisoning ,Children ,Seizures ,Dentistry ,RK1-715 ,Medicine (General) ,R5-920 - Abstract
In developing countries, accidental poisoning is a serious public health problem in children. But unintentional poisoning by parents in the form of medication is very rare. Ivermectin belongs to the group of Avermectins and is used in veterinary medicine and in use for human parasitic diseases. We report the case of 10 years old girl given ivermectin by her mother for an unspecified amount. The patient presented to the hospital with seizures and remained in a coma for five days. The patient was managed symptomatically and discharged home in stable condition with parents' counselling regarding child safety.
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- 2022
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5. NEUROLOGICAL COMPLICATIONS AND BACILLE CALMETTE-GUERIN VACCINATION STATUS OF CHILDREN WITH TUBERCULOUS MENINGITIS: A TERTIARY CARE HOSPITAL EXPERIENCE
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Bibi Aalia and Syed Sajid Hussain Shah
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tuberculosis ,meningitis ,immunization ,hydrocephalus ,stroke ,neurological deficits ,vaccination ,Medicine - Abstract
OBJECTIVE: To assess for the neurological complications and Bacille Calmette-Guerin (BCG) vaccination status of children with tuberculosis meningitis (TBM). METHODS: This retrospective study was conducted in Ayub Teaching Hospital, Abbottabad, Pakistan. Data of diagnosed case of TBM who received anti-tuberculous therapy from 2017 to 2020 was retrieved from records. Records of children, aged 6 months to 10 years of either gender were included and vaccination status was documented along with CT scan findings. Neurological complications in hospital and outcome were recorded as discharge, expiry and transfer to other hospital. RESULTS: Out of 40 patients, 17 (42.5%) were males and 23 (57.5%) females. Age ranged from 6 months to 8 years with mean age of 2.81±2.29 years. Weight ranged from 5 to 24 kg and mean weight was 10.36±4.96 kg. About 72.5% patients were
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- 2020
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6. Determinants of Vaccine Hesitancy and Refusal in Children of District Swabi Khyber Pakhtunkhwa, Pakistan
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Syed Sajid Hussain Shah, Bibi Aalia, Mubarak Zeb, and Ihsan Ullah
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Vaccination ,Vaccine Hesitancy ,Vaccine Refusal ,Myths ,Dentistry ,RK1-715 ,Medicine (General) ,R5-920 - Abstract
OBJECTIVES: The objective of the study was to evaluate factors associated with vaccine hesitancy and refusal at District Swabi, Khyber Pakhtunkhwa. METHODOLOGY: This cross-sectional study was conducted at a teaching hospital of Khyber Pakhtunkhwa District Swabi over a period of four months. Children between the ages of 9 months to 10 years from the local population admitted to the children ward/daycare centre were included in the study. Parents were inquired about vaccination status and in case of no vaccination or partial vaccination; then the reason was inquired after proper informed consent. Data were collected by using a structured proforma and analyzed using SPSS-24. RESULTS: A total of 828 children were included in this study. Out of these 492 (59.4%) were male and 336 (40.6%) were females. Of the total 828 children, 753 (90.9%) were vaccinated up to date, 48 (5.8%) were not vaccinated and 27 (3.3%) were partially vaccinated. Under vaccinated were 75 patients, 52% were left out due to misconception/beliefs, 6% patients were having issues due to living far away, 2.7% patients could not be vaccinated due to presence of other diseases and 37.3% due to lack of knowledge regarding vaccination. A significant correlation was found between the vaccination status of children and aforementioned reasons (p-value ≤0.001). CONCLUSION: The most common cause of not vaccinating children with polio vaccines was misconceptions/beliefs and lack of knowledge of the parents.
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- 2022
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7. Pain Abdomen as a Presentation of Congenital Malrotation of Gut: A Case Series
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Syed Sajid Hussain Shah, Yousaf Aziz Khan, and Bibi Aalia
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Recurrent Pain Abdomen ,Failure To Thrive ,Intestinal Malrotation ,Vomiting ,Dentistry ,RK1-715 ,Medicine (General) ,R5-920 - Abstract
Malrotation of the gut can present at any age but the majority of patients present in neonatal period or early infancy. Most children present with a history of recurrent colicky abdominal pain, vomiting which can be bilious and failure to thrive. Delay in diagnosis leads to increase in mortality and morbidity. Here we present a series of three patients, one girl aged 6 years, one 10 months old boy and one 10 years old boy, who got admitted at our Pediatric Department in a one month period. Patients had a history of recurrent abdominal pain and occasional vomiting, seen and managed by multiple paediatricians and GP doctors with extensive diagnostic workup but never the accurate diagnosis was made. Thorough history was taken and examination done, planned work up done for diagnosis. High index of suspicion is needed in children presenting with recurrent pain in the abdomen. Targeted work-up should be done and patients be kept on follow-up for diagnosis of late presentation of congenital malrotation of the gut.
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- 2021
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8. An Analytical Study of the Women’s Rights of Inheritance (In the light of Revealed Scriptures)
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Dr. Syed Ghazanfar Ahmed and Bibi Aalia
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Islam. Bahai Faith. Theosophy, etc. ,BP1-610 - Abstract
The right of women’s inheritance is quite debatable in the revealed religions. But in Islam there is crystal clear criteria and guidelines for all the heirs including women. Even in the old and new testament are silent regarding this important issue and Jews and Christians adopted the law of women inheritance from Roman law. In this paper we will discusses various cases in brief from history and will present a comparative analysis of the three religions in detail. Specifically the share of women as Mother, Sister, Daughter and Wife of deceased.
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- 2019
9. Pain Abdomen as a Presentation of Congenital Malrotation of Gut: A Case Series
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Bibi Aalia, Yousaf Aziz Khan, and Syed Sajid Hussain Shah
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medicine.medical_specialty ,business.industry ,General surgery ,media_common.quotation_subject ,medicine.disease ,Work-up ,medicine.anatomical_structure ,Intestinal malrotation ,Failure to thrive ,medicine ,Vomiting ,Abdomen ,Congenital malrotation ,Girl ,medicine.symptom ,Presentation (obstetrics) ,business ,media_common - Abstract
Malrotation of the gut can present at any age but the majority of patients present in neonatal period or early infancy. Most children present with a history of recurrent colicky abdominal pain, vomiting which can be bilious and failure to thrive. Delay in diagnosis leads to increase in mortality and morbidity. Here we present a series of three patients, one girl aged 6 years, one 10 months old boy and one 10 years old boy, who got admitted at our Pediatric Department in a one month period. Patients had a history of recurrent abdominal pain and occasional vomiting, seen and managed by multiple paediatricians and GP doctors with extensive diagnostic workup but never the accurate diagnosis was made. Thorough history was taken and examination done, planned work up done for diagnosis. High index of suspicion is needed in children presenting with recurrent pain in the abdomen. Targeted work-up should be done and patients be kept on follow-up for diagnosis of late presentation of congenital malrotation of the gut.
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- 2021
10. Vaccination Status and Clinical Spectrum of Children with Pyogenic Meningitis in A Tertiary Care Hospital of Hazara Division, Pakistan
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Syed Sajid Hussain Shah and Bibi Aalia
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Pediatrics ,medicine.medical_specialty ,Vaccination status ,business.industry ,medicine ,Tertiary care hospital ,business ,medicine.disease ,Meningitis - Abstract
Background: Pyogenic meningitis is one of the serious causes of mortality and morbidity in children. It is more prevalent in third world countries with poor vaccination coverage. This study was done to determine the vaccination status and clinical spectrum of pyogenic meningitis in children presenting to a tertiary care hospital. Methods: This cross-sectional study was carried out from August, 2017 till January, 2020 over 2.5 years. Records of children who got admitted in pediatric B ward, of either gender between ages of 1 month to 14 years diagnosed as case of pyogenic meningitis were included. Records of vaccination status along with signs of meningeal irritation, complications and outcome during hospital stay were documented. Data was analyzed by SPSS 20 and chi square test applied. P value < 0.05 was taken as significant. Results: There were 117 patients, 78 males and 39 females. Age ranged from 1 month to 14 years with mean age of 5.51± 4.19 years. Patients who were vaccinated up to date were 49.6% and 37.6% were not vaccinated at all. Main presenting feature was fever and seizures especially under one year of age. There was significant association between seizures and age group with p value of 0.001. Signs of meningeal irritation (neck stiffness, brudzinski sign, kerning sign) and paradoxical irritability were present in 85 (72.6%) patients mostly above 1 year of age. There was significant association between signs of meningeal irritation and age group (5 years and above) with p value of
- Published
- 2021
11. Response of Hepatitis B Vaccine in Children with Celiac Disease – An Experience at Ayub Teaching Hospital, Abbottabad Pakistan
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Syed Sajid Hussain Shah and Bibi Aalia
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Pediatrics ,medicine.medical_specialty ,Hepatitis B vaccine ,business.industry ,Medicine ,Disease ,business ,Teaching hospital - Abstract
Background: Celiac Disease (CD), characterized by chronic small intestinal inflammation, is an immune-mediated disorder, with a strong family history and association with DQ2 HLA haplotype. It has been postulated that children with CD show less response to hepatitis B vaccine due to overexpression of HLA-DQ2 haplotype. This study was done to determine the response of hepatitis B vaccine in children with CD in our tertiary care setting in the Hazara region of eastern Khyber Pakhtunkhwa, Pakistan.Material and Methods: This cross-sectional study was conducted in the Pediatrics outpatient department (OPD) of Ayub Teaching Hospital, Abbottabad Pakistan from April 2018 till March 2020. Children with CD (n=38) aged 1-14 years with completed HBV vaccination, anti-tissue transglutaminase IgA antibody (tTG-IgA) >150 IU/ml and/or typical histological findings of CD on small-bowel biopsy, were included in the study. Hepatitis B surface antibody (HbsAb) titer of ≥10 mIU/ml was taken as antibody positive, while HbsAb levels < 10 mIU/ml were considered as vaccine non-responsive. Data was analyzed using SPSS version 20.0. Chi square test was applied for comparison with P-value < .05 taken as significant.Results: Out of 38 diagnosed cases of CD, 15 (39.5%) were males and 23 (60.5%) were females. Mean age of children was 8.32±3.26 years with an age range of 3-14 years. HbsAb levels ranged from 0.10 to 62.7 mIU/ml with a mean of 11.2+17.42 mIU/ml. HbsAb levels were less than 10.0 IU/ml in 73.7% of children with CD. Small intestinal biopsy was performed in 11 (28.9%) patients. There was a significant relationship between anti tTG-IgA levels and histopathology findings with P-value of .001.Conclusions: In children having celiac disease, there was low rate of protective antibody response to hepatitis B vaccine.
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- 2021
12. PRESENTATION OF CHILDREN WITH MASTURBATION
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Syed Sajid Hussain, Shah, Bibi, Aalia, and Shahzad, Najeeb
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Male ,Diagnosis, Differential ,Adolescent ,Seizures ,Behavior Therapy ,Child, Preschool ,Humans ,Female ,General Medicine ,Child ,Masturbation - Abstract
Childhood masturbations (CM) is stimulation of genital by pre-adolescent children with accompanying symptoms including sweating, tachycardia, blushing, muscle contraction and increase rate of breathing. We are presenting case series of three patient, who presented with history of vague symptoms and ultimately diagnosed and managed as case of CM. A 2 years old girl presented with history of to and fro movements. A 3 years old girl presented with history of rubbing of inner thighs and 3 years old boy presented with history of holding and rubbing genitalia with forward bending and symptoms of increase breathing, flushing and sweating. Video recording was available with two patients, which helped in making final diagnosis. Parents were counselled and patients referred for behavioural therapy. Conclusion: In young child CM should be considered in differential diagnosis whenever history is not fully suggestive of seizures.
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- 2022
13. Management Of Childhood Steroid Dependent Nephrotic Syndrome With Cyclophosphamide - An Experience At Ayub Teaching Hospital, Abbottabad
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Syed Sajid, Hussain Shah, Bibi, Aalia, Ali, Raza, Shahzad, Najeeb, and Anis Ur, Rehman
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Male ,Nephrotic Syndrome ,Adolescent ,Recurrence ,Child, Preschool ,Remission Induction ,Humans ,Infant ,Female ,Steroids ,Child ,Hospitals, Teaching ,Cyclophosphamide - Abstract
This study has been done in children with Steroid dependent nephrotic syndrome (SDNS) to check for the response to cyclophosphamide and relapse on follow up for one year after completion of treatment.This study was conducted over two years and nine months. Patients were taken as steroid dependent when there were two consecutive relapses occur on steroids tapering or within two weeks of stopping treatment. Children of either sex between ages of 1-14 years, diagnosed case of SDNS were included in this study. Renal biopsy was not done in any patient. After achieving remission with oral steroids, cyclophosphamide was given after calculation of maximum cumulative dose 168 mg/kg for 8 - 12 weeks along with oral steroids. Follow up done every two weeks till completion of treatment for response and adverse effects and thereafter for one year.There were 31 patients, 23 (74.2%) male and 8 (25.8%) females. Age ranged from 1.5 years to 11 years with mean age 5.44±2.39 years. There was full response to cyclophosphamide as none of patient had proteinuria on cyclophosphamide therapy. After completion of cyclophosphamide course, four patients (12.9%) relapsed on follow up while 87.9% remain in complete remission. Only one female patient (3.23%) had adverse effect in form of hair fall and she recovered after completion of treatment. None of patient showed any other adverse effect including haematuria.Cyclophosphamide is an effective therapy in management of childhood SDNS with minimum adverse effects in medium term.
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- 2021
14. An Outcome Of Conservative Management Of Primary Nocturnal Enuresis In Children
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Syed Sajid, Hussain Shah, Bibi, Aalia, Ali, Raza, Shahzad, Najeeb, and Anis Ur, Rehman
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Male ,Treatment Outcome ,Adolescent ,Child, Preschool ,Humans ,Female ,Child ,Conservative Treatment ,Nocturnal Enuresis - Abstract
Primary nocturnal enuresis is one of the common problems in children. Mostly parents are concern for this condition in children and also children are depressive from this condition. The main stay of treatment is the training of child. The objective of this study was to look for the outcome of conservative management of primary nocturnal enuresis.This study was done in OPD of paediatrics department. Patients aged five year or more were included in the study. Patient age, weight, sex, blood pressure, family history in siblings and parents, number of wet days/week, recorded on specific proforma along with renal function tests. Patients were advised fluid restriction after evening and micturition before sleep and after 2-3 hours of sleep. Follow up was done after six months to observe for the impact of habit change. Data has been analysed by SPSS 20 and results are taken significant with p-value0.05.Out of 81 patients, 41 were male and 40 females. Age ranged from 5 to 14 years and mean age was 8.2±2.35 years. There were 11.1% parents who had primary nocturnal enuresis during childhood and in 29.6% siblings, history was positive. Follow up at 6 months, 58% patients improved while 42% showed no improvement. There was significant relationship between evening fluid restriction, micturition before and after sleep with improvement at 6 months with p-value of 0.010,0.001 and 0.002 respectively.Conservative management is the effective intervention in children as parents should be emphasized for habit change.
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- 2021
15. NEUROLOGICAL COMPLICATIONS AND BACILLE CALMETTE-GUERIN VACCINATION STATUS OF CHILDREN WITH TUBERCULOUS MENINGITIS: A TERTIARY CARE HOSPITAL EXPERIENCE
- Author
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Syed Sajid Hussain Shah and Bibi Aalia
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Pediatrics ,medicine.medical_specialty ,Tuberculosis ,business.industry ,Mortality rate ,Retrospective cohort study ,medicine.disease ,Tuberculous meningitis ,Hydrocephalus ,General Health Professions ,medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Complication ,business ,General Dentistry ,Stroke ,Meningitis - Abstract
OBJECTIVE: To assess for the neurological complications and Bacille Calmette-Guerin (BCG) vaccination status of children with tuberculosis meningitis (TBM). METHODS: This retrospective study was conducted in Ayub Teaching Hospital, Abbottabad, Pakistan. Data of diagnosed case of TBM who received anti-tuberculous therapy from 2017 to 2020 was retrieved from records. Records of children, aged 6 months to 10 years of either gender were included and vaccination status was documented along with CT scan findings. Neurological complications in hospital and outcome were recorded as discharge, expiry and transfer to other hospital. RESULTS: Out of 40 patients, 17 (42.5%) were males and 23 (57.5%) females. Age ranged from 6 months to 8 years with mean age of 2.81±2.29 years. Weight ranged from 5 to 24 kg and mean weight was 10.36±4.96 kg. About 72.5% patients were
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- 2020
16. Therapeutic and vaccine strategies against SARS-CoV-2: past, present and future
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Mubasher Rehman, Sajid Hussain Shah, Muhammad Junaid, Isfahan Tauseef, Kashif Syed Haleem, and Bibi Aalia
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0301 basic medicine ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,viruses ,coronavirus ,Review ,drugs ,03 medical and health sciences ,0302 clinical medicine ,Virology ,vaccine ,medicine ,Global health ,Intensive care medicine ,skin and connective tissue diseases ,nCoV ,business.industry ,SARS-CoV-2 ,fungi ,virus diseases ,COVID-19 ,body regions ,030104 developmental biology ,030220 oncology & carcinogenesis ,business - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019. It was first reported in Wuhan, China and has since become a global health concern. Keeping in view, the magnitude of the problem, scientists around the globe are working to develop effective therapeutic strategies. This review focuses on previous findings regarding SARS-CoV, which may prove helpful in future research on SARS-CoV-2. In addition, it also highlights recent developments in medicine and biotechnology toward developing effective drugs and vaccines against SARS-CoV-2. This review will analyze available data on this topic and will help researchers develop new thoughts using information already available as a step toward developing novel therapeutic strategies against SARS-CoV-2.
- Published
- 2020
17. Age-related variations in the in vitro bactericidal activity of human sera against Pseudomonas aeruginosa
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Nighat Sultana, Kashif Syed Haleem, Sadia Akbar, Muhammad Azam Khan, Akram Khan, Isfahan Tauseef, and Bibi Aalia
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0301 basic medicine ,Innate immune system ,biology ,Pseudomonas aeruginosa ,Immunology ,Pseudomonas ,Human pathogen ,medicine.disease_cause ,biology.organism_classification ,In vitro ,Microbiology ,Complement system ,03 medical and health sciences ,030104 developmental biology ,medicine ,Immunology and Allergy ,Pathogen ,Bacteria - Abstract
The human serum is a vital component of the innate immunity of the host that acts as the first line of defence against invading pathogens. A key player in serum-mediated innate immune defence is a system of more than 35 proteins, collectively named as the complement system. After exposure of the pathogen, these proteins are activated in a cascade manner, ultimately forming a membrane attack complex (MAC) on the surface of the pathogen that directly lyses the bacterial cell. Formation of the MAC can be demonstrated in vitro by using serum bactericidal assay (SBA) that works in the absence of cellular components of blood after incubating the serum along with bacteria. Here, we describe the age-related differences in the bactericidal activity of human serum against Pseudomonas aeruginosa, an opportunistic human pathogen causing an array of hospital and community-acquired infections. We demonstrate that adult sera were highly effective in the in vitro killing of Pseudomonas aeruginosa as compared to children and the elderly (p < 0.0001). Sera from children were seriously compromised in the killing P. aeruginosa, whereas elderly sera showed a reduced level of killing. Data revealed a positive correlation between age and serum-killing with higher coefficient of determination values of 0.34, 0.27, and 0.58 and p values of < 0.0001, < 0.001, and < 0.0001, respectively, after 60, 90, and 120 minutes of incubation. Hence, our study highlights the age-related difference in the bactericidal activity of human sera. We conclude that sera of children are totally compromised, whereas elderly sera are only partially compromised, in the killing of P. aeruginosa.
- Published
- 2018
18. Age-related variations in the
- Author
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Akram, Khan, Isfahan, Tauseef, Bibi, Aalia, Muhammad Azam, Khan, Sadia, Akbar, Nighat, Sultana, and Kashif S, Haleem
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Experimental Immunology ,Pseudomonas ,serum bactericidal assay ,complement system - Abstract
The human serum is a vital component of the innate immunity of the host that acts as the first line of defence against invading pathogens. A key player in serum-mediated innate immune defence is a system of more than 35 proteins, collectively named as the complement system. After exposure of the pathogen, these proteins are activated in a cascade manner, ultimately forming a membrane attack complex (MAC) on the surface of the pathogen that directly lyses the bacterial cell. Formation of the MAC can be demonstrated in vitro by using serum bactericidal assay (SBA) that works in the absence of cellular components of blood after incubating the serum along with bacteria. Here, we describe the age-related differences in the bactericidal activity of human serum against Pseudomonas aeruginosa, an opportunistic human pathogen causing an array of hospital and community-acquired infections. We demonstrate that adult sera were highly effective in the in vitro killing of Pseudomonas aeruginosa as compared to children and the elderly (p < 0.0001). Sera from children were seriously compromised in the killing P. aeruginosa, whereas elderly sera showed a reduced level of killing. Data revealed a positive correlation between age and serum-killing with higher coefficient of determination values of 0.34, 0.27, and 0.58 and p values of < 0.0001, < 0.001, and < 0.0001, respectively, after 60, 90, and 120 minutes of incubation. Hence, our study highlights the age-related difference in the bactericidal activity of human sera. We conclude that sera of children are totally compromised, whereas elderly sera are only partially compromised, in the killing of P. aeruginosa.
- Published
- 2017
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